Endocrinology and Metabolism

Volume 22(1); February 2007

Review Article

Sarcopenia of the Old Age.: Seok Won Park; J Korean Endocr Soc. 2007;22(1):1-7. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.1

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Abstract PDF

No abstract available.

Citations

Citations to this article as recorded by

Association between Handgrip Strength and Psychological Distress: The Korea National Health and Nutrition Examination Survey (2015 and 2017)
Bo Ra Hyun, Yeong Sook Yoon, Yun Jun Yang, Eon Sook Lee, Jun Hyung Lee, Youn Huh, Chang Hyun Jhung, Do Dam Pang, Bo Ram Kang
Korean Journal of Family Practice.2021; 11(5): 338. CrossRef
Leucine-Enriched Protein Supplementation Increases Lean Body Mass in Healthy Korean Adults Aged 50 Years and Older: A Randomized, Double-Blind, Placebo-Controlled Trial
Yeji Kang, Namhee Kim, Yong Jun Choi, Yunhwan Lee, Jihye Yun, Seok Jun Park, Hyoung Su Park, Yoon-Sok Chung, Yoo Kyoung Park
Nutrients.2020; 12(6): 1816. CrossRef
Clinical Implication of Sarcopenia in Patients with Inflammatory Bowel Disease
Seong-Eun Kim
The Korean Journal of Gastroenterology.2018; 71(6): 308. CrossRef
Effects of Sarcopenic Obesity on Metabolic Syndrome in Korean Elders: Using Data from the Korea National Health and Nutrition Examination Survey (2008-2011)
Hyun-A Choi, Kyung-Min Park
Journal of Korean Academy of Community Health Nursing.2016; 27(3): 231. CrossRef
Prevalence of Sarcopenia in Healthy Korean Elderly Women
Eun Sil Lee, Hyoung Moo Park
Journal of Bone Metabolism.2015; 22(4): 191. CrossRef

Editorial

Aldosterone as a Cardiovascular Risk Factor.: Soon Jib Yoo; J Korean Endocr Soc. 2007;22(1):8-10. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.8

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Abstract PDF: No abstract available.

Original Articles

Comparison of Target Organ Damages between Primary Aldosteronism and Essential Hypertension.: Juri Park, Dong Jin Kim, Sae Jeong Yang, Sook Hae Kim, Soo Yeon Park, Hye Jin Yoo, Yun Jeong Lee, Hee Young Kim, Ohk Hyun Ryu, Kye Won Lee, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi; J Korean Endocr Soc. 2007;22(1):11-18. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.11

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BACKGROUND
A number of recent clinical studies have reported marked target organ damages in patients with primary aldosteronism. The aim of this study was to compare the incidence of target organ damages in patients with primary aldosteronism (PA) and essential hypertension (EHT). METHODS: The clinical records of 41 PA patients, over a 20-year period, were retrospectively analyzed. The clinical characteristics and incidence of target organ damages of 33 of the patients in this group were compared with those of 66 patients with essential hypertension, directly matched for age, gender and mean blood pressure. 8 of the PA patients could not be matched with EHT patients for age, gender and mean blood pressure, so were excluded from the comparison. The patients with essential hypertension were sampled from patients who visited for the evaluation of hypertension. RESULTS: Ischemic heart diseases were found in 18.2 and 10.6% of patients with PA and EHT, respectively (P = 0.22). From echocardiograms, left ventricular hypertrophy was found in 93.3% and 61.4% of patients with PA and EHT, respectively (P = 0.017). The degrees of left ventricular hypertrophy were correlated with the levels of serum aldosterone, with an r value of 0.490 (P < 0.005). Cerebrovascular attack was found in 18.2% and 1.5% of patients with PA and EHT, respectively (P = 0.005). Hypertensive retinopathy was found in 50% and 33.3% of patients with PA and EHT (P = 0.255), and nephropathy was found in 42.4% and 25.8% of patients with PA and EHT, respectively (P = 0.074). CONCLUSION: Patients with primary aldosteronism had target organ damages more frequently than with those with essential hypertension, which was independent of blood pressure.

Citations

Citations to this article as recorded by

Changes in the clinical manifestations of primary aldosteronism
Sun Hwa Kim, Jae Hee Ahn, Ho Cheol Hong, Hae Yoon Choi, Yoon Jung Kim, Nam Hoon Kim, Hye Jin Yoo, Hee Young Kim, Ji A Seo, Nan Hee Kim, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi
The Korean Journal of Internal Medicine.2014; 29(2): 217. CrossRef
Comparing the Prevalence of Primary Aldosteronism in Hypertensive Diabetic and Non-diabetic Patients
Yi Sun Jang, Koon Soon Kim, Hye Soo Kim
Journal of Korean Endocrine Society.2009; 24(4): 254. CrossRef
Aldosterone as a Cardiovascular Risk Factor
Soon Jib Yoo
Journal of Korean Endocrine Society.2007; 22(1): 8. CrossRef

Lipid Profile Changes in Postmenopausal Korean Women Treated with Alendronate (10 mg) for 2 Years: Comparing with Control Group.: Il Woo Joo, Han Jin Oh; J Korean Endocr Soc. 2007;22(1):19-25. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.19

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Abstract PDF

BACKGROUND
Bisphosphonate, which has been used for prevention and treatment of osteoporosis with the mechanism of inhibiting bone resorption, also has an association with the cholesterol synthethic process. This suggests that bisphosphonate might have benefit to improve the lipid profile in humans through a process that blocks the mevalonate-squalene pathway. However, few reports have revealed the relationship between the action of bisphosphonate and lipid metabolism in postmenopausal Korean women. We planned this study to determine the effect of alendronate (10 mg) on the serum lipid level in postmenopausal Korean women. Subjects and METHODS: We retrospectively evaluated the postmenopausal Korean women (aged over 50) who visited the Osteoporosis clinic in the Health Care Center in Seoul from March of 2003 to October of 2005. The changes of the serum lipid levels, including total cholesterol, triglyceride, and HDL cholesterol, after 2-years of alendronate 10 mg administration were evaluated and comparing to a control group. RESULTS: After 2-years alendronate (10 mg) administration, the total cholesterol was decreased by 11.8 +/- 3.7 mg/dL, and the HDL cholesterol was increased by 5.2 +/-1.4 mg/dL as compared to the baseline lipid level. Both of these results showed statistical significance. Changes of the triglyceride and fasting blood glucose also showed a decline by 15.4 +/-9.8 mg/dL and 6.0 +/-1.4 mg/dL, respectively, but this was not statistically significant. However, in the control group, the total cholesterol was increased by 9.4 +/-8.8 mg/dL, and the triglyceride was increased by 10.5 +/-7.2 mg/dL as compared to the baseline lipid level. Both of the results showed statistical significance. CONCLUSION: Alendronate might have a beneficial effect on lipid metabolism to decrease cholesterol and increase HDL. Taking into consideration about the postmenopausal increase in the cholesterol level, alendronate is recommended for the prevention of hyperlipidemia in postmenopausal women, in addition to preventing and treating osteoporosi

Citations

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The effect of alendronate on lipid profile of postmenopausal women with osteopenia and prediabetes: A randomized triple-blind clinical trial
Maryam Karimifard, Ashraf Aminorroaya, Massoud Amini, Ali Kachuie, Awat Feizi, SimaAminorroaya Yamini, MolukHadi Alijanvand
Journal of Research in Medical Sciences.2021; 26(1): 52. CrossRef

The Relationship between the Expression of MHC Class II Antigens and the Clinical Prognosis of Papillary Thyroid Carcinoma Patients.: Jun Chul Lee, Seul Young Kim, Yun Sun Choi, Youn Sun Bai, Yun Jeung Kim, Ihn Suk Lee, Ki Hyun Kwon, So Young Rha, Bon Jeong Ku, Young Kun Kim, Heung Kyu Ro, Shengjin Li, Jin Man Kim, Young Suk Jo, Minho Shong; J Korean Endocr Soc. 2007;22(1):26-34. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.26

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Abstract PDF: BACKGROUND
Papillary thyroid carcinoma is among the most curable cancers, but some patients are at high risk for recurrence or even death. MHC antigens are essential molecules for the pathogenesis of carcinoma and also the physiologic immune responses against tumor. However, there is no data about the relationship between the expression of MHC antigens and the clinical prognosis of papillary thyroid carcinoma patients. METHODS: We analyzed the relationship between the various prognostic factors and the MHC antigen expression by conducting a retrospective study of 215 patients, who had undergone thyroidectomy for papillary thyroid carcinoma between 1987 and 2003. RESULTS: The expressions of MHC class II antigens were more frequent in papillary thyroid carcinoma than in the other thyroid diseases. Yet there was no statistically significant relationship between most of the clinicopathological factors and the expression of MHC class II antigens in papillary thyroid carcinoma patients. Interestingly, an HLA-DR expression was found in 8 (30.8%) of the 26 patients in the recurrence group and in 13 (76.5%) of the 17 patients in the non-recurrence group, and HLA-DP/DQ immunoreactivity was positive in 10 (38.5%) cases of the recurrence group and in 14 (82.4%) cases of the non-recurrence group. CONCLUSION: Papillary thyroid carcinoma showed a more frequent expression of MHC Class II antigens. However, the recurred papillary thyroid carcinoma showed a tendency to downregulate the expression of MHC class II antigens. Hence, the molecular mechanism for the expression of MHC class II antigens might have a role in the recurrence of papillary thyroid carcinoma.

Effects of Wnt-1 on the Growth and Apoptosis of FRTL-5 Cells.: Jung Min Kim, Tae Yong Kim, Young Kee Shong, Yoon Soo Rhee, Eun Jung Park, Hyun Chung Choi, Won Bae Kim; J Korean Endocr Soc. 2007;22(1):35-44. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.35

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Abstract PDF: BACKGROUND
Wnt proteins are major signaling molecules involved in embryonic induction, generation of cell polarity and the cell fate decision. A central player in the Wnt signaling pathways is beta-catenin. Several studies have suggested that the Wnt/beta-catenin signaling pathway may be involved in the physiologic/pathologic control of thyroid cell growth and function. METHODS: We investigated the effect of thyroid-stimulating hormone (TSH) on the expression of Wnt proteins in FRTL-5 cells. To evaluate the effect of Wnt-1 on FRTL-5 cells growth, we isolated a stable cell line that overexpressed Wnt-1 (W1), and a vector-transfected cell clone (V3) was used as a control. We investigated the differences in the cellular growth rate, the cell cycle and cell apoptosis in the W1 and V3 cell lines. RESULTS: TSH caused a significant increase in the Wnt-1 level and a pronounced decrease in both the active and total beta-catenin levels in the FRTL-5 cells. The growth rate, the percentage of cells in the S/G2/M phase and the c-myc level were significantly higher in the W1 cells compared with the V3 cells. There was no change in the beta-catenin level and the cyclin D1 level in the W1 cells compared with the V3 cells. The cellular apoptosis induced by actinomycin-D seemed to be significantly decreased because the level of bcl-2 was increased in the W1 cells compared with the V3 cells. CONCLUSION: The FRTL-5 cells expressed Wnt-1 protein, and TSH increased the Wnt-1 expression, and it paradoxically decreased beta-catenin in the FRTL-5 cells. Overexpression of Wnt-1 in the FRTL-5 cells increased cell growth and it decreased apoptosis. Growth stimulation by Wnt-1 overexpression was not mediated by beta-catenin (the canonical Wnt pathway), but seemed to be mediated by activation of the Wnt/Ca2+ pathway, which involves an increased c-myc level. Suppression of apoptosis with Wnt-1 overexpression was due to the increased bcl-2 level.

Case Reports

p-ANCA Positive Vasculitis after Propylthiouracil (PTU) Medication in a Patient with Graves' Disease.: Chan Kwon Park, Yun Hwa Jung, Ji Hyeon Ju, Hyun Sook Kim, Chong Hyeon Yoon, Young Il Seo, Ho Youn Kim, Sung Hwan Park; J Korean Endocr Soc. 2007;22(1):45-49. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.45

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Abstract PDF: A 34-year old woman was admitted to our hospital complaining of fever and multiple palpable purpura. She presented with symmetrical, polymorphic, dark-violet and black colored, edematous, tender, necrotic ulcerations and palpable purpuric lesions on her upper and lower extremities and face, except for her trunk, after restarting PTU therapy for relapsing Graves' disease. Palpable purpura can have many causes, including infectious and autoimmune processes. A rare cause is drug-induced vasculitis, and this may result from the production of antineutrophil cytoplasmic antibodies (ANCAs) in response to a medication. The patient's PTU-induced vasculitis was diagnosed by skin biopsy, and biopsy displayed remarkable p-ANCA positivity. The skin lesions resolved immediately after discontinuation of the drug and steroid therapy. We report here on a case of PTU induced vasculitis in a woman with Graves' disease who presented with palpable purpuric lesions and myeloperoxidase ANCA positivity in the blood. We observed clinical resolution of her symptoms following withdrawal of the PTU.

A Case of Thyroid Microcarcinoma with Multiple Metastases, Including Liver Metastasis.: Sang Jin Lee, Won Gu Kim, Hyung Yong Kim, Hyun Gi Lee, Tae Yong Kim, Youn Suck Koh; J Korean Endocr Soc. 2007;22(1):50-54. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.50

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Abstract PDF: A 65-year-old woman presented with a dry cough and multiple various sized nodules in both lungs on chest X-ray. A CT scan showed a 9.5 cm sized hypervascular mass in the liver and a 5.5 cm sized intraabdominal mass. A percutaneous needle biopsy of one of the lung nodules revealed a metastatic follicular thyroid carcinoma. Therefore, thyroid ultrasonography was performed, which revealed a 1 cm sized nodule in the right thyroid lobe. Cytology, obtained by ultrasonography guided fine needle aspiration, revealed a follicular neoplasm. The tumor cells were weakly positive on galectin-3 immunostaining, which favored a follicular carcinoma. An ultrasonography guided biopsy of the liver and EUS (endoscopic ultrasonography)-guided biopsy of the intraabdominal mass revealed a metastatic follicular thyroid carcinoma in the liver and peritoneum. We report a very rare case of a follicular thyroid microcarcinoma, with multiple metastases to the lung, liver and peritoneum.

A Case of Osteomalacia Caused by Severe Vitamin D Deficiency.: Seok Yeon Kim, Sang Youl Rhee, Soo Young Moon, Suk Chon, In Kyung Jeong, Seungjoon Oh, Kyu Jeung Ahn, Deog Yoon Kim, Ho Yeon Chung, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Jeong Taek Woo; J Korean Endocr Soc. 2007;22(1):55-61. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.55

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Abstract PDF

Vitamin D is a kind of hormone that can be synthesized in the skin or it is supplied in the diet it is involved in a central role in bone and calcium homeostasis in vivo. Metabolic bone diseases such as rickets in children and osteomalacia in adults can also be caused by deficiency or metabolic defects in the vitamin D hormone related system. However, there has been a lack of generalized epidemiologic studies about the vitamin D deficiency status in Koreans. We recently experienced a case of osteomalacia caused by severe vitamin D deficiency. These kinds of case have not been reported elsewhere in Korea for the last twenty years.

Citations

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A Case of Nutritional Osteomalacia in Young Adult Male
Choong-Kyun Noh, Min-Jeong Lee, Bu Kyung Kim, Yoon-Sok Chung
Journal of Bone Metabolism.2013; 20(1): 51. CrossRef

A Case of Cushing's Disease with Renal Cell Carcinomaand End-stage Renal Disease.: Jang Eun Lee, Ik Jun Choi, Young Jai Park, Hyo Jin Lee, Kyoung Hwan Lee, Seung Hyun Ko, Ki Ho Song, Yu Bai Ahn; J Korean Endocr Soc. 2007;22(1):62-67. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.62

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Abstract PDF: Cushing's disease is the most common cause of endogenous Cushing's syndrome caused by the excessive secretion of adrenocorticotropic hormone (ACTH) by pituitary ACTH-secreting tumors. The tumors are usually microadenomas (< 10 mm in diameter). Macroadenomas are rare, and corticotroph hyperplasia and carcinomas are extremely rare. Patients with these tumors exhibit an increase in plasma ACTH and cortisol levels, elevated urinary excretion of cortisol and adrenocortical steroid metabolites, evidence of altered negative feedback of cortisol and disturbances in neuroendocrine regulation. The diagnosis of Cushing's disease can be challenging in patients with renal failure the presence of abnormal plasma cortisol, poor gastrointestinal tract absorption of dexamethasone and altered functioning of the hypophyseal-pituitary-adrenal axis have been reported in end-stage renal disease, and the urinary cortisol increment method is not reliable in these patients. The prevalence of renal cell carcinoma in patients on dialysis is higher than in the general population. We recently treated a patient with Cushing's disease and end-stage renal disease as a result of renal cell carcinoma. The diagnosis was made by laboratory evaluation of plasma and radiological examination. Here we report a case of Cushing's disease with a review of the medical literature.

A Case of Familial Multiple Endocrine Neoplasia Type 1 with MEN1 Gene Mutation.: Young Eun Jo, Yong Jun Choi, Yun Kyung Kim, Sang Mi Ahn, Sun Hye Jung, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee, Ji Hee Hong, Seon Yong Jeong, Hyon J Kim, Yoon Sok Chung; J Korean Endocr Soc. 2007;22(1):68-73. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.68

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Abstract PDF

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the combined occurrence of parathyroid, pancreatic islet and pituitary gland tumors. It is caused by mutation of the MEN1, a tumor suppressor gene, with more than 400 different MEN1 mutations having been described. Herein is reported the case of a 26-year-old woman who had complained of personality and behavior changes, coupled with repetitive loss of consciousness. Her random plasma glucose and insulin were 68 mg/dL and 67.3 microIU/mL, respectively. Two pancreatic masses were noted on abdominal computed tomography, with hypercalcemia noted from a routine chemistry test. Her diagnosis was that of MEN1; therefore, her first-degree relatives were also screened. DNA analysis was also performed, from which a MEN1 gene mutation (738del4 -> new nomenclature: 628del4) was detected. Knowledge of the MEN1 mutation status could provide early recognition of a tumor.

Citations

Citations to this article as recorded by

Genetic and Epigenetic Analysis in Korean Patients with Multiple Endocrine Neoplasia Type 1
Yoon Jung Chung, Sena Hwang, Jong Ju Jeong, Sun Yong Song, Se Hoon Kim, Yumie Rhee
Endocrinology and Metabolism.2014; 29(3): 270. CrossRef
Somatic Mutational Analysis of MEN1 and Phenotypic Correlation in Sporadic Parathyroid Tumors
Young Su Chae, Hee Jin Kim, Sun Wook Kim, Myung-Chul Chang
Journal of the Korean Surgical Society.2009; 76(1): 15. CrossRef

The Endocrinological Characteristics of Rathke's Cleft Cyst: Pathologically Confirmed in Seven Cases.: Su Kyong Yu, Yun Kyung Kim, Hye Jin Kim, Dae Jung Kim, Yoon Sok Chung, Kwan Woo Lee, Se Hyuk Kim, Kyung Gi Cho; J Korean Endocr Soc. 2007;22(1):74-79. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.74

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Abstract PDF

Rathke's cleft cyst is a cystic sellar or suprasellar lesion thought to originate from the remnants of Rathke's pouch. It is characteristically lined by a single layer of ciliated cuboidal or columnar epithelium. Although small asymptomatic Rathke's cleft cysts have been reported at autopsy in 2~26% of normal pituitary glands, symptomatic cysts are rare. For patients with symptomatic Rathke's cleft cysts presentation with headache, pituitary dysfunction, and visual loss caused by compression of the optic chiasm in the event of suprasellar extension, is common. We report the endocrine characteristics of seven cases of patients with symptomatic Rathke's cleft cyst diagnosed with pathologic confirmation.

Citations

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Risk factor for pituitary dysfunction in children and adolescents with Rathke's cleft cysts
Han Hyuk Lim, Sei Won Yang
Korean Journal of Pediatrics.2010; 53(7): 759. CrossRef

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