The incidence of thyroid cancer is growing the fastest among all cancers in the United States, especially in women. The number of patients with thyroid neoplasm is part of an even larger number of patients who often need to undergo an operation to exclude a cancer diagnosis. While differentiated thyroid cancer (papillary thyroid cancer and follicular thyroid cancer) accounts for most cases of thyroid cancer and has a relatively good prognosis, effective treatments for patients with de-differentiated and anaplastic thyroid cancer are still gravely needed. Despite progress in the identification of genetic changes in thyroid cancer, the impact of aberrant epigenetic alterations on thyroid cancer remains to be fully elucidated. Understanding of the roles of epigenetic changes in thyroid cancer could open new opportunities for the identification of innovative molecular targets for novel treatment modalities, especially for anaplastic thyroid cancer for which treatment is very limited. This article briefly reviews the studies that exemplify the potential for and promise of using epigenetic regulators in the treatment of thyroid cancer.

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• Challenges and Coping Strategies of Older Adults in the Aftermath of Kahramanmaraş Earthquake in Türkiye: A Qualitative Research
  Nilgun Kuru Alici, Bilge Kalanlar
  Journal of Applied Gerontology.2024;[Epub]     CrossRef
• CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p
  Mei Zheng, Lingli Xu, Cuifeng Wei, Wenzhen Guan
  Hormones.2023; 22(2): 281.     CrossRef
• The expression of HDAC9 and P300 in papillary thyroid carcinoma cell line
  Hatice Ozisik, Berrin Ozdil, Aslı Suner, Murat Sipahi, Mehmet Erdogan, Sevki Cetinkalp, Gokhan Ozgen, Fusun Saygili, Gulgun Oktay, Huseyin Aktug
  Pathology - Research and Practice.2023; 243: 154385.     CrossRef
• Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications
  Valerie Jacquemin, Mathieu Antoine, Geneviève Dom, Vincent Detours, Carine Maenhaut, Jacques E. Dumont
  Cancers.2022; 14(2): 280.     CrossRef
• Thyroid Carcinoma: A Review for 25 Years of Environmental Risk Factors Studies
  Eva Kruger, Eman A. Toraih, Mohammad H. Hussein, Shaimaa A. Shehata, Amani Waheed, Manal S. Fawzy, Emad Kandil
  Cancers.2022; 14(24): 6172.     CrossRef
• Study of Essential and Toxic Metal Imbalances in the Scalp Hair of Thyroid Cancer Patients in Comparison with Healthy Donors
  Kalsoom Bibi, Munir H. Shah
  Biological Trace Element Research.2021; 199(2): 500.     CrossRef
• Modern concepts of the molecular pathogenesis of thyroid cancer
  A. A. Mikhailova, A. V. Shestakov, K. A. Chubakova, E. V. Kolokolova, V. Yu. Eliseev, M. Ya. Kostyaeva, E. G. Akperov, V. E. Pilipenko, T. V. Saprina, M. R. Mukhamedov, E. L. Choinzonov
  Advances in Molecular Oncology.2021; 8(2): 8.     CrossRef
• Effect of valproic acid on miRNAs affecting histone deacetylase in a model of anaplastic thyroid cancer
  Nur Selvi Gunel, Nihal Birden, Cansu Caliskan Kurt, Bakiye Goker Bagca, Behrouz Shademan, Fatma Sogutlu, Neslihan Pinar Ozates, Cigir Biray Avci
  Molecular Biology Reports.2021; 48(8): 6085.     CrossRef
• Histone Deacetylase Inhibitors and Papillary Thyroid Cancer
  Eleftherios Spartalis, Konstantinos Kotrotsios, Dimosthenis Chrysikos, Michael Spartalis, Stavroula A. Paschou, Dimitrios Schizas, Konstantinos Tsamakis, Dimitrios Dimitroulis, Theodore Troupis, Nikolaos Nikiteas
  Current Pharmaceutical Design.2021; 27(18): 2199.     CrossRef
• HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer
  Ching-Ling Lin, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Li-Chi Huang, Chia-Hwa Lee
  International Journal of Molecular Sciences.2019; 20(2): 454.     CrossRef
• Systems Biology Approaches to Investigate Genetic and Epigenetic Molecular Progression Mechanisms for Identifying Gene Expression Signatures in Papillary Thyroid Cancer
  Shan-Ju Yeh, Chien-Yu Lin, Cheng-Wei Li, Bor-Sen Chen
  International Journal of Molecular Sciences.2019; 20(10): 2536.     CrossRef
• Human telomerase reverse transcriptase in papillary thyroid cancer: gene expression, effects of silencing and regulation by BET inhibitors in thyroid cancer cells
  Valentina Maggisano, Marilena Celano, Saverio Massimo Lepore, Marialuisa Sponziello, Francesca Rosignolo, Valeria Pecce, Antonella Verrienti, Federica Baldan, Catia Mio, Lorenzo Allegri, Marianna Maranghi, Rosa Falcone, Giuseppe Damante, Diego Russo, Stef
  Endocrine.2019; 63(3): 545.     CrossRef
• Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review
  Maria Fiore, Gea Oliveri Conti, Rosario Caltabiano, Antonino Buffone, Pietro Zuccarello, Livia Cormaci, Matteo Angelo Cannizzaro, Margherita Ferrante
  International Journal of Environmental Research and Public Health.2019; 16(7): 1185.     CrossRef