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Original Articles
- Clinical Study
- Trends in Hyperglycemic Crisis Hospitalizations and in- and out-of-Hospital Mortality in the Last Decade Based on Korean National Health Insurance Claims Data
- Ji Hong You, Sun Ok Song, Se Hee Park, Kyoung Hye Park, Joo Young Nam, Dong Wook Kim, Hyun Min Kim, Dong-Jun Kim, Yong-ho Lee, Byung-Wan Lee
- Endocrinol Metab. 2019;34(3):275-281. Published online September 26, 2019
- DOI: https://doi.org/10.3803/EnM.2019.34.3.275
- 7,285 View
- 97 Download
- 8 Web of Science
- 10 Crossref
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Abstract
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PubReader 
ePub Background Hyperglycemic crisis is a metabolic emergency associated with diabetes mellitus. However, accurate epidemiologic information on cases of hyperglycemic crisis in Korea remains scarce. We evaluated trends in hyperglycemic crisis hospitalizations and in- and out-of-hospital mortality in Korea. We also predicted future trends.
Methods We extracted claims data with hyperglycemic crisis as the principal diagnosis from the National Health Insurance Service database in Korea from January 2004 to December 2013. We investigated the numbers of claims with hyperglycemic crisis and identified trends in hyperglycemic crisis based on those claims data. We predicted future trends by statistical estimation.
Results The total annual number of claims of hyperglycemic crisis increased from 2,674 in 2004 to 5,540 in 2013. Statistical analysis revealed an increasing trend in hyperglycemic crisis hospitalizations (
P for trend <0.01). In contrast, the hospitalization rate per 1,000 diabetes cases showed a decreasing trend (P for trend <0.01) during this period. The mortality rate per 1,000 diabetes cases also showed a decreasing trend (P for trend <0.0001). However, no distinct linear trend in the case-related fatality rate at <60 days over the last decade was observed. The predicted number of annual claims of hyperglycemic crisis will increase by 2030.Conclusion The number of hyperglycemic crisis hospitalizations in Korea increased in the last decade, although the hospitalization rate per 1,000 diabetes cases and mortality rate decreased. Also, the predicted number of annual claims will increase in the future. Thus, it is necessary to establish long-term healthcare policies to prevent hyperglycemic crisis.
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Citations
Citations to this article as recorded by
- Enhancing outcome prediction by applying the 2019 WHO DM classification to adults with hyperglycemic crises: A single-center cohort in Thailand
Chatchon Kaewkrasaesin, Weerapat Kositanurit, Phawinpon Chotwanvirat, Nitchakarn Laichuthai
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(4): 103012. CrossRef - Obesity and 30-day case fatality after hyperglycemic crisis hospitalizations in Korea: a national cohort study
Hojun Yoon, Hyun Ho Choi, Giwoong Choi, Sun Ok Song, Kyoung Hwa Ha, Dae Jung Kim
Cardiovascular Prevention and Pharmacotherapy.2023; 5(3): 74. CrossRef - Interpreting global trends in type 2 diabetes complications and mortality
Mohammed K. Ali, Jonathan Pearson-Stuttard, Elizabeth Selvin, Edward W. Gregg
Diabetologia.2022; 65(1): 3. CrossRef - Comparison of the clinical characteristics and outcomes of pediatric patients with and without diabetic ketoacidosis at the time of type 1 diabetes diagnosis
Young-Jun Seo, Chang Dae Kum, Jung Gi Rho, Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
Annals of Pediatric Endocrinology & Metabolism.2022; 27(2): 126. CrossRef - Clinical characteristics and outcomes of care in patients hospitalized with diabetic ketoacidosis
Mohsen S. Eledrisi, Haifaa Alkabbani, Malk Aboawon, Aya Ali, Imad Alabdulrazzak, Maab Elhaj, Ashraf Ahmed, Hazim Alqahwachi, Joanne Daghfal, Salem A. Beshyah, Rayaz A. Malik
Diabetes Research and Clinical Practice.2022; 192: 110041. CrossRef - Hyperglycemic Crisis Characteristics and Outcome of Care in Adult Patients without and with a History of Diabetes in Tigrai, Ethiopia: Comparative Study
Getachew Gebremedhin, Fikre Enqueselassie, Helen Yifter, Negussie Deyessa
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 547. CrossRef - Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea
Min Jeong Han, Jun Ho Heo
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 783. CrossRef - Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports
Na-young Kim, Eunyeong Ha, Jun Sung Moon, Yong-Hoon Lee, Eun Young Choi
Diabetes & Metabolism Journal.2020; 44(2): 349. CrossRef - Letter: Trends in Hyperglycemic Crisis Hospitalizations and in- and out-of-Hospital Mortality in the Last Decade Based on Korean National Health Insurance Claims Data (Endocrinol Metab 2019;34:275–81, Ji Hong You et al.)
Jang Won Son
Endocrinology and Metabolism.2019; 34(4): 422. CrossRef - Response: Trends in Hyperglycemic Crisis Hospitalizations and in- and out-of-Hospital Mortality in the Last Decade Based on Korean National Health Insurance Claims Data (Endocrinol Metab 2019;34:275–81, Ji Hong You et al.)
Ji Hong You, Sun Ok Song
Endocrinology and Metabolism.2019; 34(4): 424. CrossRef
- Enhancing outcome prediction by applying the 2019 WHO DM classification to adults with hyperglycemic crises: A single-center cohort in Thailand
- Clinical Study
- Prognostic Factors in Patients Hospitalized with Diabetic Ketoacidosis
- Avinash Agarwal, Ambuj Yadav, Manish Gutch, Shuchi Consul, Sukriti Kumar, Ved Prakash, Anil Kumar Gupta, Annesh Bhattacharjee
- Endocrinol Metab. 2016;31(3):424-432. Published online September 1, 2016
- DOI: https://doi.org/10.3803/EnM.2016.31.3.424
- 4,737 View
- 82 Download
- 28 Web of Science
- 26 Crossref
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Abstract
PDFPubReader
Background Diabetic ketoacidosis (DKA) is characterized by a biochemical triad of hyperglycemia, acidosis, and ketonemia. This condition is life-threatening despite improvements in diabetic care. The purpose of this study was to evaluate the clinical and biochemical prognostic markers of DKA. We assessed correlations in prognostic markers with DKA-associated morbidity and mortality.
Methods Two hundred and seventy patients that were hospitalized with DKA over a period of 2 years were evaluated clinically and by laboratory tests. Serial assays of serum electrolytes, glucose, and blood pH were performed, and clinical outcome was noted as either discharged to home or death.
Results The analysis indicated that significant predictors included sex, history of type 1 diabetes mellitus or type 2 diabetes mellitus, systolic blood pressure, diastolic blood pressure, total leukocyte count, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, blood urea nitrogen, serum creatinine, serum magnesium, serum phosphate, serum osmolality, serum glutamic oxaloacetic transaminases, serum glutamic pyruvic transaminases, serum albumin, which were further regressed and subjected to multivariate logistic regression (MLR) analysis. The MLR analysis indicated that males were 7.93 times more likely to have favorable outcome compared with female patients (odds ratio, 7.93; 95% confidence interval, 3.99 to 13.51), while decreases in mean APACHE II score (14.83) and serum phosphate (4.38) at presentation may lead to 2.86- and 2.71-fold better outcomes, respectively, compared with higher levels (APACHE II score, 25.00; serum phosphate, 6.04).
Conclusion Sex, baseline biochemical parameters such as APACHE II score, and phosphate level were important predictors of the DKA-associated mortality.
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Citations
Citations to this article as recorded by- Prognosis of patients with extreme acidosis on admission to the emergency department: A retrospective cohort study
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
The American Journal of Emergency Medicine.2024; 76: 36. CrossRef - The critical role of pen needles and training in insulin delivery
Tracey Sainsbury
British Journal of Nursing.2024; 33(5): 242. CrossRef - Clinical characteristics of people with diabetic ketoacidosis at a clinic in The Gambia: a retrospective study
Orighomisan F Agboghoroma, Modou Jobe, Karen Forrest
Journal of Endocrinology, Metabolism and Diabetes of South Africa.2023; 28(1): 14. CrossRef - Elevated alanine transaminase is nonlinearly associated with in-hospital death in ICU-admitted diabetic ketoacidosis patients
Qiaoling Liu, Chen Gong, Yunjie Geng, Jiuhong You
Diabetes Research and Clinical Practice.2023; 197: 110555. CrossRef - Diabetic keto-acidosis in pancreatic diabetes – how is it different from DKA in type 1 or type 2 DM?
Sunetra Mondal, Riddhi DasGupta, Moushumi Lodh, Ashok Parida, Mandira Haldar, Arunangshu Ganguly
International Journal of Diabetes in Developing Countries.2023;[Epub] CrossRef - Comparative study of diabetic ketoacidosis in the elderly and non-elderly patients: A nine-year experience from an academic hospital in North India
Ashok Kumar Pannu, Ravindran Kiran, Abhishek Kumar, Saurabh Chandrabhan Sharda, Mandip Bhatia, Atul Saroch, Pinaki Dutta, Navneet Sharma
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(12): 102903. CrossRef - Clinical Profile and Outcome of Diabetic Ketoacidosis in Type 1 and Type 2 Diabetes: A Comparative Study
Sachin Kamle, Madhuri Holay, Prashant Patil, Parimal Tayde
Vidarbha Journal of Internal Medicine.2022; 32: 21. CrossRef - Effect of subjective tool based aerobic exercise on pulmonary functions in patients with type 2 diabetes mellitus – a feasibility RCT
M. Saini, J. Kaur
Comparative Exercise Physiology.2022; 18(3): 239. CrossRef - Clinical characteristics and outcomes of care in patients hospitalized with diabetic ketoacidosis
Mohsen S. Eledrisi, Haifaa Alkabbani, Malk Aboawon, Aya Ali, Imad Alabdulrazzak, Maab Elhaj, Ashraf Ahmed, Hazim Alqahwachi, Joanne Daghfal, Salem A. Beshyah, Rayaz A. Malik
Diabetes Research and Clinical Practice.2022; 192: 110041. CrossRef - An Audit of Factors Impacting the Time to Resolution of the Metabolic Parameters in Diabetic Ketoacidosis Patients
Muath F AlWahbi , Sami H Alharbi, Saleh A Almesned, Faisal A Alfawzan, Rayan T Alsager, Abdullah A AlHojailan, Emad A Alfadhel, Fahad G Al-Harbi
Cureus.2022;[Epub] CrossRef - Incidence of Diabetic Ketoacidosis among Adults with Type 1 Diabetes in Saudi Arabia: Systematic review
Ayoub Ali Alshaikh, Rawan Zaifallh Alsalman, Nada Hamzah Albarqi, Razan Salem Alqahtani, Ali Ahmed Almontashri, Atheer Saud Alshahrani, Mohammed Abdullah Alshehri
Pharmacophore.2022; 13(4): 105. CrossRef - Features and long‐term outcomes of patients hospitalized for diabetic ketoacidosis
Michal Michaelis, Tzippy Shochat, Ilan Shimon, Amit Akirov
Diabetes/Metabolism Research and Reviews.2021;[Epub] CrossRef - Incidence, characteristics and long-term outcomes of patients with diabetic ketoacidosis: a prospective prognosis cohort study in an emergency department
Rachel Teixeira Leal Nunes, Carolina Frade Magalhães Girardin Pimentel Mota, Paulo Ricardo Gessolo Lins, Fernanda Salles Reis, Thais Castanheira de Freitas Resende, Ludmila de Andrade Barberino, Pedro Henrique Luiz da Silva, Aecio Flavio Teixeira de Gois
Sao Paulo Medical Journal.2021; 139(1): 10. CrossRef - Management of diabetic ketoacidosis in special populations
Mohsen S. Eledrisi, Salem A. Beshyah, Rayaz A. Malik
Diabetes Research and Clinical Practice.2021; 174: 108744. CrossRef - Profile of diabetic ketoacidosis at the National Diabetes and Endocrine Center in Tripoli, Libya, 2015
Aida Elkituni, Halla Elshwekh, Nesrein M. Bendala, Wafeya S. Atwear, Fawzia A. Aldaba, Abdulmunam M. Fellah
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Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4819. CrossRef - Diabetic ketoacidosis
Ketan K. Dhatariya, Nicole S. Glaser, Ethel Codner, Guillermo E. Umpierrez
Nature Reviews Disease Primers.2020;[Epub] CrossRef - Risk and Relevance of Insulin Pump Therapy in the Aetiology of Ketoacidosis in People with Type 1 Diabetes
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Experimental and Clinical Endocrinology & Diabetes.2020; 128(11): 745. CrossRef - Clinical and biochemical profile, precipitants and prognostic factors of diabetic ketoacidosis: A retrospective study from a tertiary care center of north India
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Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(4): 2357. CrossRef - Sudden death due to diabetic ketoacidosis following power failure of an insulin pump: Autopsy and pump data
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Journal of Forensic and Legal Medicine.2019; 63: 34. CrossRef - Defining and characterising diabetic ketoacidosis in adults
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Diabetes Research and Clinical Practice.2019; 155: 107797. CrossRef - Effects of diabetic ketoacidosis in the respiratory system
Alice Gallo de Moraes, Salim Surani
World Journal of Diabetes.2019; 10(1): 16. CrossRef - Increasing Hospitalizations for DKA: A Need for Prevention Programs
Priyathama Vellanki, Guillermo E. Umpierrez
Diabetes Care.2018; 41(9): 1839. CrossRef - Guidelines and controversies in the management of diabetic ketoacidosis – A mini-review
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World Journal of Diabetes.2018; 9(12): 226. CrossRef - Closing the Mortality Gap in Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: Implications of a Clinical Decision Support App
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International Journal of Clinical Endocrinology and Metabolism.2018; : 008. CrossRef - Incidence and prevalence of diabetic ketoacidosis (DKA) among adults with type 1 diabetes mellitus (T1D): a systematic literature review
Soulmaz Fazeli Farsani, Kimberly Brodovicz, Nima Soleymanlou, Jan Marquard, Erika Wissinger, Brett A Maiese
BMJ Open.2017; 7(7): e016587. CrossRef
- Prognosis of patients with extreme acidosis on admission to the emergency department: A retrospective cohort study
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