Fig. 1(A, B) Preoperative magnetic resonance imaging. A 3.4-cm enhanced mass (arrows) with lobulated contour at the cavernous sinus extending into the sellar region (A, axial view; B, coronal view). (C, D) Three months after radiosurgery, the enhanced mass exhibits a decrease in the extent of the lobulated contour at the cavernous sinus extending into the sellar region (C, axial view; D, coronal view).
Fig. 2A 2.5-cm arterial wall enhancing mass with distal p-duct dilatation in the pancreas body (arrows).
Fig. 3(A, B) On histologic examination, the mass was composed of dilated vessels occasionally containing thrombi (A, H&E stain, ×100; B, H&E stain, ×400). (C) Immunohistochemically, these endothelial cells were fully reactive in CD31 (CD31, ×400). These findings were indicative of cavernous hemangioma.
Fig. 4Polymerase chain reaction-direct sequencing demonstrates the tumor's heterogeneous pattern and variant allele, suggesting that a change occurred to the nucleotide sequence from the GCA to ACA (alanine to threonine).
Fig. 5PolyPhen-2 is a tool for prediction of the possible impact of amino acid substitutions on the structure and function of human proteins. The PolyPhen-2 report indicates that the heterogeneous c.1621G>A (Ala541Thr) mutation is predicted to be benign.
Table 1Combined Pituitary Stimulation Test (Cocktail Test)
Table 2Polymerase Chain Reaction Primers Used for MEN1 Somatic Mutation Analysis
Table 3Summary of the Clinical Profile of Previously Reported Intrasellar Cavernous Hemangiomas