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1Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
2Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Copyright © 2018 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
SNP, single-nucleotide polymorphism; RA, risk allele; OA, other allele; OR, odds ratio; NE, not established; DIRC3, disrupted in renal carcinoma 3; NRG1, neuregulin 1; PTCSC2, papillary thyroid carcinoma susceptibility candidate 2; FOXE1, forkhead box E1; 5′UTR, 5′ untranslated region; USF1/USF2, upstream transcription factor 1/2; C/EBP, CCAAT (cytosine-cytosine-adenosine-adenosine-thymidine)/enhancer binding protein; PTCSC3, papillary thyroid carcinoma susceptibility candidate 3; NKX2-1, NK2 homeobox 1; MBIP1, MAP3K12 binding inhibitory protein 1; PCNXL2, pecanex homolog 2; LRRC34, leucine rich repeat containing 34; TERT, telomerase reverse transcriptase; EPB41L4A, erythrocyte membrane protein band 4.1 like 4A; OBFC1, STN1, CST complex subunit; SMAD3, SMAD family member 3.
aData according to the results from [24]; bAllelic effect size in terms of odds ratio; cReplication studies in Asian population(s); dData from the target gene study ref [16]; eZero allelic frequency in the Asian populations.
SNP, single-nucleotide polymorphism; RA, risk allele; OA, other allele; OR, odds ratio; DIRC3, disrupted in renal carcinoma 3; NRG1, neuregulin 1; FOXE1, forkhead box E1; NKX2-1, NK2 homeobox 1; PCNXL2, pecanex homolog 2; MSRB3, methionine sulfoxide reductase B3; VAV3, vav guanine nucleotide exchange factor 3; SEPT11, septin 11; FHIT, fragile histidine triad; INSR, insulin receptor; 3′UTR, 3′ untranslated region; SLC24A6, solute carrier family 8 member B1; SLC8B1, solute carrier family 8 member B1.
aData according to the results from [40]; bAllelic effect size in terms of odds ratio; cSame SNPs genotyped in the European populations, see Table 1; dThis SNP displayed the strongest association with FTC: allelic frequency 0.07, OR=3.32.