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1Department of Medicine, Endocrinology and Metabolism, University of Sherbrooke, Sherbrooke, QC, Canada.
2Department of Medicine, Oregon Health & Science University, Portland, OR, USA.
3Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA.
4Northwest Pituitary Center, Oregon Health & Science University, Portland, OR, USA.
Copyright © 2017 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: Maria Fleseriu has been a principal investigator with research grants to OHSU and scientific consultant to Chiasma, Novartis, Pfizer, Strongbridge. Fabienne Langlois and Shirley McCartney have no conflict of interest.
N, nausea; D, diarrhea; AI, adrenal insufficiency; TBD, to be determined; HTN, hypertension; IV, intravenous; V, vomiting; ICU, intensive care unit; NA, not available; SC, subcutaneous; CD, Cushing disease; LAR, long-acting release; IM, intramuscular; CS, Cushing syndrome.
aPregnancy categories: A (Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk), B (May be acceptable. Animal studies showed minor risks and human studies showed no risk), C (Use with caution if benefits outweigh risks. Either no studies available or only animal studies show risk and human studies not available), D (Positive evidence of human fetal risk. Use in last resort, as salvage therapy for emergencies when no safer drug available), X (Do not use in pregnancy. Risks outweigh benefits, use alternatives).
SC, subcutaneous; N, nausea; V, vomiting; D, diarrhea; LAR, long-acting release; IM, intramuscular; NA, not available; GH, growth hormone.
aPregnancy categories: A (Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk), B (May be acceptable. Animal studies showed minor risks and human studies showed no risk), C (Use with caution if benefits outweigh risks. Either no studies available or only animal studies show risk and human studies not available), D (Positive evidence of human fetal risk. Use in last resort, as salvage therapy for emergencies when no safer drug available), X (Do not use in pregnancy. Risks outweigh benefits, use alternatives).
N, nausea; V, vomiting; GI, gastrointestinal; TBD, to be determined; NA, not available; CD, Cushing disease.
aPregnancy categories: A (Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk), B (May be acceptable. Animal studies showed minor risks and human studies showed no risk), C (Use with caution if benefits outweigh risks. Either no studies available or only animal studies show risk and human studies not available), D (Positive evidence of human fetal risk. Use in last resort, as salvage therapy for emergencies when no safer drug available), X (Do not use in pregnancy. Risks outweigh benefits, use alternatives).