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Sarcopenia and Muscle Aging: A Brief Overview
Tam Dao, Alexander E. Green, Yun A Kim, Sung-Jin Bae, Ki-Tae Ha, Karim Gariani, Mi-ra Lee, Keir J. Menzies, Dongryeol Ryu
Endocrinol Metab. 2020;35(4):716-732.   Published online December 23, 2020
DOI: https://doi.org/10.3803/EnM.2020.405
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  • 110 Web of Science
  • 115 Crossref
AbstractAbstract PDFPubReader   ePub   
The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns. Sarcopenia is a condition which is defined by the gradual loss of skeletal muscle mass and function with age. In research and clinical practice, sarcopenia is recognized as a component of geriatric disease and is a current target for drug development. In this review we define this condition and provide an overview of current therapeutic approaches. We further highlight recent findings that describe key pathophysiological phenotypes of this condition, including alterations in muscle fiber types, mitochondrial function, nicotinamide adenine dinucleotide (NAD+) metabolism, myokines, and gut microbiota, in aged muscle compared to young muscle or healthy aged muscle. The last part of this review examines new therapeutic avenues for promising treatment targets. There is still no accepted therapy for sarcopenia in humans. Here we provide a brief review of the current state of research derived from various mouse models or human samples that provide novel routes for the development of effective therapeutics to maintain muscle health during aging.

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    Journal of Advanced Research.2025; 68: 403.     CrossRef
  • Intramuscular administration of fractalkine modulates mitochondrial properties and promotes fast glycolytic phenotype
    Gourabamani Swalsingh, Punyadhara Pani, Unmod Senapati, Bijayashree Sahu, Sunil Pani, Benudhara Pati, Subhasmita Rout, Naresh C. Bal
    BioFactors.2025;[Epub]     CrossRef
  • Prospective Intervention Strategies Between Skeletal Muscle Health and Mitochondrial Changes During Aging
    Xin Zhang, Suchan Liao, Lingling Huang, Jinhua Wang
    Advanced Biology.2025;[Epub]     CrossRef
  • The effect of biocide chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture on C2C12 muscle cell damage attributed to mitochondrial reactive oxygen species overproduction and autophagy activation
    Donghyun Kim, Yusun Shin, Yong-Wook Baek, HanGoo Kang, Jungyun Lim, Ok-Nam Bae
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  • Combating Cellular Aging: Frontiers in Biomaterials and Therapies
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    ACS Materials Letters.2025; 7(1): 1.     CrossRef
  • Knee strength balance ratios are not affected by aging among male runners
    Ronaldo Alves da Cunha, Vinícius Ribeiro dos Anjos Souza, Lavínia Vivan, Aldo Seffrin, Claudio Andre Barbosa de Lira, Katja Weiss, Beat Knechtle, Marilia Santos Andrade
    Journal of Exercise Science & Fitness.2025; 23(2): 77.     CrossRef
  • The role of chronic low-grade inflammation in the development of sarcopenia: Advances in molecular mechanisms
    Ying Cheng, Shangjin Lin, Ziyi Cao, Runzhi Yu, Yongqian Fan, Jie Chen
    International Immunopharmacology.2025; 147: 114056.     CrossRef
  • Gut microbiota in patients with sarcopenia: a systematic review and meta-analysis
    Guangning Wang, Yujie Li, Huisong Liu, Xinjuan Yu
    Frontiers in Microbiology.2025;[Epub]     CrossRef
  • Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age
    Yuan Li, Laura Berliocchi, Zhiquan Li, Lene Juel Rasmussen
    Aging Cell.2024;[Epub]     CrossRef
  • Circulating lumican as a potential biomarker for osteosarcopenia in older adults
    So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
    Bone.2024; 179: 116959.     CrossRef
  • D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?
    Jan Homolak, Ana Babic Perhoc, Davor Virag, Ana Knezovic, Jelena Osmanovic Barilar, Melita Salkovic‐Petrisic
    BioEssays.2024;[Epub]     CrossRef
  • Dark tea extract attenuates age-related muscle loss by suppressing oxidative stress and inflammation in skeletal muscle of mice
    Ahyoung Yoo, Hyo Deok Seo, Jeong-Hoon Hahm, Chang Hwa Jung, Jiyun Ahn, Tae Youl Ha
    Journal of Functional Foods.2024; 112: 105980.     CrossRef
  • Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation
    Sobha Tumbapo, Adam Strudwick, Jana J. Stastna, Simon C. Harvey, Marieke J. Bloemink
    Mechanisms of Ageing and Development.2024; 217: 111900.     CrossRef
  • Trop T, hand grip strength and waist circumference as markers of sarcopenic obesity in postmenopausal women: An analytical cross-sectional study
    Sheetal Sarangi, Arul Senghor K. A., Vinodhini V. M.
    Indian Journal of Physiology and Pharmacology.2024; 68: 57.     CrossRef
  • Temporal Muscle Thickness: A Practical Approximation for Assessing Muscle Mass in Older Adults
    Miguel German Borda, Jonathan Patricio Baldera, Jessica Samuelsson, Anna Zettergren, Lina Rydén, Eric Westman, Mario Ulises Pérez-Zepeda, Silke Kern, Luis Carlos Venegas, Gustavo Duque, Ingmar Skoog, Dag Aarsland
    Journal of the American Medical Directors Association.2024; 25(4): 664.     CrossRef
  • Undernutrition in obese older adults by fat percentage
    Meris Esra Bozkurt, Tugba Erdogan, Nezahat Muge Catikkas, Serdar Ozkok, Cihan Kilic, Gulistan Bahat, Mehmet Akif Karan
    Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
  • Telomere Length is Associated with the Prevalence, Persistence, and Incidence of Sarcopenia
    Aaron Salinas-Rodriguez, Betty Manrique-Espinoza, Ana Rivera-Almaraz, José Manuel Sánchez-López, Haydeé Rosas-Vargas
    Archives of Medical Research.2024; 55(4): 103007.     CrossRef
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    Raúl Fabero-Garrido, Miguel Gragera-Vela, Tamara del Corral, Marta Hernández-Martín, Gustavo Plaza-Manzano, Ibai López-de-Uralde-Villanueva
    Life.2024; 14(3): 411.     CrossRef
  • Sarcopenia and non-alcoholic fatty liver disease
    R. G. Myazin
    Experimental and Clinical Gastroenterology.2024; (2): 120.     CrossRef
  • Establishing an optimal diagnostic criterion for respiratory sarcopenia using peak expiratory flow rate
    Yerim Do, Youngeun Lim, Jiyoun Kim, Haneul Lee
    Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
  • THE ROLE OF DAIRY FOODS FOR HEALTHY AGING
    Emine Kocyigit
    Anti-Aging Eastern Europe.2024; 3(1): 23.     CrossRef
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    Katherine E. Simon, Katharine Russell, Alejandra Mondino, Chin-Chieh Yang, Beth C. Case, Zachary Anderson, Christine Whitley, Emily Griffith, Margaret E. Gruen, Natasha J. Olby
    Scientific Reports.2024;[Epub]     CrossRef
  • Association between the systemic immune-inflammation index and sarcopenia: a systematic review and meta-analysis
    Siye Xie, Qi Wu
    Journal of Orthopaedic Surgery and Research.2024;[Epub]     CrossRef
  • Muscle-specific PGC-1α modulates mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2
    Lei Song, Jianfeng Xue, Lingfen Xu, Lin Cheng, Yongxia Zhang, Xiaojun Wang
    Experimental Gerontology.2024; 193: 112468.     CrossRef
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    Yan Zhang, Shibo Wei, Hang Zhang, Yunju Jo, Jong-Sun Kang, Ki-Tae Ha, Jongkil Joo, Hyun Joo Lee, Dongryeol Ryu
    BMB Reports.2024; 57(5): 207.     CrossRef
  • Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model
    Ashok D. Prabakaran, Kevin McFarland, Karen Miz, Hima Bindu Durumutla, Kevin Piczer, Fadoua El Abdellaoui Soussi, Hannah Latimer, Cole Werbrich, Hyun-Jy Chung, N. Scott Blair, Douglas P. Millay, Andrew J. Morris, Brendan Prideaux, Brian N. Finck, Mattia Q
    Journal of Clinical Investigation.2024;[Epub]     CrossRef
  • Differences in Type 2 Fiber Composition in the Vastus Lateralis and Gluteus Maximus of Patients with Hip Fractures
    Jingwen Tian, Minchul Song, Kyu Jeong Cho, Ho Yeop Lee, Sang Hyeon Ju, Jung Ryul Lim, Ha Thi Nga, Thi Linh Nguyen, Ji Sun Moon, Hyo Ju Jang, Jung-Mo Hwang, Hyon-Seung Yi
    Endocrinology and Metabolism.2024; 39(3): 521.     CrossRef
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    Selene Escudero-Bautista, Arianna Omaña-Covarrubias, Ana Teresa Nez-Castro, Lydia López-Pontigo, Maribel Pimentel-Pérez, Alonso Chávez-Mejía
    Geriatrics.2024; 9(5): 110.     CrossRef
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    Wenbin Wu, Xinlu Guo, Taiqi Qu, Yuejia Huang, Jin Tao, Jian He, Xiaoping Wang, Junjie Luo, Peng An, Yinhua Zhu, Yanan Sun, Yongting Luo
    Nutrients.2024; 16(12): 1958.     CrossRef
  • New insights into the function of the NLRP3 inflammasome in sarcopenia: mechanism and therapeutic strategies
    Yunyi Zou, Xiangbin Tang, Siyuan Yang, Zhanglin Chen, Bin Liu, Zuoqiong Zhou, Xiyang Peng, Changfa Tang
    Metabolism.2024; 158: 155972.     CrossRef
  • Dietary Protein and Physical Exercise for the Treatment of Sarcopenia
    Rosarita Nasso, Antonio D’Errico, Maria Letizia Motti, Mariorosario Masullo, Rosaria Arcone
    Clinics and Practice.2024; 14(4): 1451.     CrossRef
  • Particulate matter 2.5 accelerates aging: Exploring cellular senescence and age-related diseases
    Sheng-nan Wang, Yan-chuan Shi, Shu Lin, He-fan He
    Ecotoxicology and Environmental Safety.2024; 284: 116920.     CrossRef
  • Sphingolipid metabolites as potential circulating biomarkers for sarcopenia in men
    Je Hyun Seo, Jung‐Min Koh, Han Jin Cho, Hanjun Kim, Young‐Sun Lee, Su Jung Kim, Pil Whan Yoon, Won Kim, Sung Jin Bae, Hong‐Kyu Kim, Hyun Ju Yoo, Seung Hun Lee
    Journal of Cachexia, Sarcopenia and Muscle.2024; 15(6): 2476.     CrossRef
  • Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions
    Enzo Pereira de Lima, Masaru Tanaka, Caroline Barbalho Lamas, Karina Quesada, Claudia Rucco P. Detregiachi, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Virgínia Maria Cavallari Strozze Catharin, Marcela Vialogo Marques de Castro, Edgar Baldi Junior, M
    Biomedicines.2024; 12(9): 2096.     CrossRef
  • Effects of household solid fuel use on sarcopenia in middle-aged and older adults: evidence from a nationwide cohort study
    Shaohui Su, Yinuo Zhou, Kerui Wang, Aonan Liu, Lei Lei, Hao Ma, Yanfang Yang
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Sarcopenia and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review
    Ludovico Abenavoli, Michael Statsenko, Giuseppe Guido Maria Scarlata, Domenico Morano, Roman Myazin, Dmitriy Emelyanov
    Livers.2024; 4(4): 495.     CrossRef
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    Ageing Research Reviews.2024; 101: 102534.     CrossRef
  • Exploring SGLT-2 inhibitors and sarcopenia in FAERS: a post-marketing surveillance study
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    Expert Opinion on Drug Safety.2024; : 1.     CrossRef
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    Food Science & Nutrition.2024; 12(11): 8779.     CrossRef
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    Nutrients.2024; 16(21): 3621.     CrossRef
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    International Journal of Pharmaceutics.2024; 667: 124901.     CrossRef
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    Yu-tong Wang, Sheng-yuan Zheng, Shi-de Jiang, Yan Luo, Yu-xiang Wu, Shinen Naranmandakh, Yu-sheng Li, Shu-guang Liu, Wen-feng Xiao
    Pharmacological Research.2024; 210: 107480.     CrossRef
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    Jiale Wu, Jun Tang, Di Huang, Yu Wang, Enyuan Zhou, Qin Ru, Guodong Xu, Lin Chen, Yuxiang Wu
    Frontiers in Aging Neuroscience.2024;[Epub]     CrossRef
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    Kai Yin, Chengmin Zhang, Zihan Deng, Xiaoyu Wei, Tingwen Xiang, Chuan Yang, Can Chen, Yueqi Chen, Fei Luo
    The FASEB Journal.2024;[Epub]     CrossRef
  • An immunohistochemical evaluation of fast twitch muscle formation induced by repeated administration of flavan 3‐ols in mice
    Yamato Yoshida, Kenta Shimizu, Hitomi Nakamura, Yasuyuki Fujii, Tilman Fritsch, Ali Abdelhameed, Vittorio Calabrese, Naomi Osakabe
    The FASEB Journal.2024;[Epub]     CrossRef
  • The recent development, application, and future prospects of muscle atrophy animal models
    Gongchang Zhang, Fengjuan Hu, Tingting Huang, Xiaoqing Ma, Ying Cheng, Xiaolei Liu, Wenzhou Jiang, Birong Dong, Chenying Fu
    MedComm – Future Medicine.2024;[Epub]     CrossRef
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    Juewon Kim, Yunju Jo, Gyumin Lim, Yosep Ji, Jong-Hwa Roh, Wan-Gi Kim, Hyon-Seung Yi, Dong Wook Choi, Donghyun Cho, Dongryeol Ryu
    Nature Communications.2024;[Epub]     CrossRef
  • Higher Circulating Resistin Levels Linked to Increased Sarcopenia Risk in Older Adults
    Mi Kyung Kwak, Ji Yeon Baek, So Jeong Park, Hee-Won Jung, Eunju Lee, Il-Young Jang, Eunhye Ji, Eun-Gyoung Hong, Yunju Jo, Dongryeol Ryu, Beom-Jun Kim
    The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
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    Applied Sciences.2023; 13(2): 986.     CrossRef
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    Journal of Asthma.2023; 60(2): 304.     CrossRef
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    Journal of Analytical Science and Technology.2023;[Epub]     CrossRef
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    Biomedicines.2023; 11(2): 598.     CrossRef
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    Foods.2023; 12(5): 1021.     CrossRef
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    Medicine.2023; 102(16): e33581.     CrossRef
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    Faxue Zhang, Tianzhou Li, Bingbing Chen, Nuoya Li, Xupeng Zhang, Shijie Zhu, Gaichan Zhao, Xiaowei Zhang, TingTing Ma, Fang Zhou, Hao Liu, Wei Zhu
    Ecotoxicology and Environmental Safety.2023; 258: 114962.     CrossRef
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    Yanhu Wang, Lei Wang, Cheng Chen, Yifan Que, Yinyi Li, Jiang Luo, Ming Yin, Miao Lv, Guogang Xu, Anita Pye
    Canadian Respiratory Journal.2023; 2023: 1.     CrossRef
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    JHEP Reports.2023; 5(10): 100835.     CrossRef
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    Biochemical Pharmacology.2023; 214: 115674.     CrossRef
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    Deeksha Malhan, Britt Schoenrock, Müge Yalçin, Dieter Blottner, Angela Relόgio
    Aging Cell.2023;[Epub]     CrossRef
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    Sunghwan Ji, Kyunggon Kim, So Jeong Park, Jin Young Lee, Hee-Won Jung, Hyun Ju Yoo, Il-Young Jang, Eunju Lee, Ji Yeon Baek, Beom-Jun Kim
    Endocrinology and Metabolism.2023; 38(6): 701.     CrossRef
  • Familial Correlation and Heritability of Hand Grip Strength in Korean Adults (Korea National Health and Nutrition Examination Survey 2014 to 2019)
    Seong Hee Ahn, Eun Byeol Park, Seongha Seo, Yongin Cho, Da Hea Seo, So Hun Kim, Young Ju Suh, Seongbin Hong
    Endocrinology and Metabolism.2023; 38(6): 709.     CrossRef
  • Ageing with neuromuscular disease: Implications for a lifeworld‐led care through a humanising approach
    Louise Abildgaard Møller, Bente Martinsen, Ulla Werlauf, Pia Dreyer
    Journal of Clinical Nursing.2022; 31(17-18): 2507.     CrossRef
  • CT-derived relationship between low relative muscle mass and bone damage in patients with multiple myeloma undergoing stem cells transplantation
    Alberto Stefano Tagliafico, Federica Rossi, Bianca Bignotti, Lorenzo Torri, Alessandro Bonsignore, Liliana Belgioia, Alida Domineitto
    The British Journal of Radiology.2022;[Epub]     CrossRef
  • A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
    Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song
    Biomedicine & Pharmacotherapy.2022; 147: 112636.     CrossRef
  • Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle
    James W. Daily, Sunmin Park
    Cells.2022; 11(3): 338.     CrossRef
  • Change of Computed Tomography-Based Body Composition after Adrenalectomy in Patients with Pheochromocytoma
    Yousun Ko, Heeryoel Jeong, Seungwoo Khang, Jeongjin Lee, Kyung Won Kim, Beom-Jun Kim
    Cancers.2022; 14(8): 1967.     CrossRef
  • Acute bioenergetic insulin sensitivity of skeletal muscle cells: ATP-demand-provoked glycolysis contributes to stimulation of ATP supply
    Rosie A. Donnell, Jane E. Carré, Charles Affourtit
    Biochemistry and Biophysics Reports.2022; 30: 101274.     CrossRef
  • The Hunt Is On! In Pursuit of the Ideal Stem Cell Population for Cartilage Regeneration
    T. Mark Campbell, F. Jeffrey Dilworth, David S. Allan, Guy Trudel
    Frontiers in Bioengineering and Biotechnology.2022;[Epub]     CrossRef
  • Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia
    Seong Hee Ahn, Hee-Won Jung, Eunju Lee, Ji Yeon Baek, Il-Young Jang, So Jeong Park, Jin Young Lee, Eunah Choi, Yun Sun Lee, Seongbin Hong, Beom-Jun Kim
    Endocrinology and Metabolism.2022; 37(3): 487.     CrossRef
  • Effects of Muscles on Bone Metabolism—with a Focus on Myokines
    Beom-Jun Kim
    Annals of Geriatric Medicine and Research.2022; 26(2): 63.     CrossRef
  • Sclerostin as a Putative Myokine in Sarcopenia
    Hyon-Seung Yi
    Endocrinology and Metabolism.2022; 37(3): 430.     CrossRef
  • Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
    Naoki Ito, Ai Takatsu, Hiromi Ito, Yuka Koike, Kiyoshi Yoshioka, Yasutomi Kamei, Shin-ichiro Imai
    Cell Reports.2022; 40(4): 111131.     CrossRef
  • Restoration of NAD+homeostasis protects C2C12 myoblasts and mouse levator ani muscle from mechanical stress-induced damage
    Guotao Huang, Yong He, Li Hong, Min Zhou, Xiaohu Zuo, Zhihan Zhao
    Animal Cells and Systems.2022; 26(4): 192.     CrossRef
  • Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
    Yunju Jo, Min-Kyung Yeo, Tam Dao, Jeongho Kwon, Hyon‐Seung Yi, Dongryeol Ryu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Development and Verification of a Combined Diagnostic Model for Sarcopenia with Random Forest and Artificial Neural Network
    Shangjin Lin, Cong Chen, Xiaoxi Cai, Fengjian Yang, Yongqian Fan, Rajesh Kaluri
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Bronchial Asthma and Sarcopenia: An Upcoming Potential Interaction
    Nikolaos D. Karakousis, Ourania S. Kotsiou, Konstantinos I. Gourgoulianis
    Journal of Personalized Medicine.2022; 12(10): 1556.     CrossRef
  • Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes
    Kyohei Furukawa, Marika Kousaka, Huijuan Jia, Hisanori Kato
    Nutrients.2022; 14(19): 3979.     CrossRef
  • Normative reference values and regression equations to predict the 6-minute walk distance in the Asian adult population aged 21–80 years
    Meredith T. Yeung, Melissa Y. Chan, Katherin S. Huang, Tian Jie Chen, Cyprian P. Chia, Meihiko M. Fong, Cherilyn S. Ho, Derek T. Koh, Mitchell J. Neo, Mark Tan
    Hong Kong Physiotherapy Journal.2022; 42(02): 111.     CrossRef
  • Food insecurity as a risk factor of sarcopenic obesity in older adults
    Diana Fonseca-Pérez, Cecilia Arteaga-Pazmiño, Claudia P. Maza-Moscoso, Sara Flores-Madrid, Ludwig Álvarez-Córdova
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Transcriptome Sequencing Analysis of circRNA in Skeletal Muscle between Fast- and Slow-Growing Chickens at Embryonic Stages
    Genxi Zhang, Jin Zhang, Pengfei Wu, Xuanze Ling, Qifan Wang, Kaizhi Zhou, Peifeng Li, Li Zhang, Hongxin Ye, Qi Zhang, Qingyu Wei, Tao Zhang, Xinglong Wang
    Animals.2022; 12(22): 3166.     CrossRef
  • Amino Acids in Cancer and Cachexia: An Integrated View
    Maurizio Ragni, Claudia Fornelli, Enzo Nisoli, Fabio Penna
    Cancers.2022; 14(22): 5691.     CrossRef
  • Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia
    Mengting Yin, He Zhang, Qianhui Liu, Fei Ding, Lisha Hou, Yiping Deng, Tao Cui, Yixian Han, Yijun Chen, Chen Huang, Jirong Yue, Yong He
    BMC Geriatrics.2022;[Epub]     CrossRef
  • The inflammatory response, a mixed blessing for muscle homeostasis and plasticity
    Zineb Bouredji, Anteneh Argaw, Jérôme Frenette
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
    Da Ae Kim, So Jeong Park, Jin Young Lee, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Beom-Jun Kim
    Endocrinology and Metabolism.2021; 36(2): 455.     CrossRef
  • Association of Water Intake with Hand Grip Strength in Community-Dwelling Older Adults
    Hyeonmok Kim, Sun Hee Beom, Tae Ho Kim, Beom-Jun Kim
    Nutrients.2021; 13(6): 1756.     CrossRef
  • Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics
    Jong Hyeon Yoon, Ki-Sun Kwon
    Endocrinology and Metabolism.2021; 36(3): 478.     CrossRef
  • Redox Signaling and Sarcopenia: Searching for the Primary Suspect
    Nicholas A. Foreman, Anton S. Hesse, Li Li Ji
    International Journal of Molecular Sciences.2021; 22(16): 9045.     CrossRef
  • Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor
    Jin Young Lee, Da Ae Kim, Eunah Choi, Yun Sun Lee, So Jeong Park, Beom-Jun Kim
    Endocrinology and Metabolism.2021; 36(4): 865.     CrossRef
  • Artificial‐intelligence‐driven discovery of prognostic biomarker for sarcopenia
    Heewon Chung, Yunju Jo, Dongryeol Ryu, Changwon Jeong, Seong‐Kyu Choe, Jinseok Lee
    Journal of Cachexia, Sarcopenia and Muscle.2021; 12(6): 2220.     CrossRef
  • Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients
    Yun Im Lee, Ryoung-Eun Ko, Joonghyun Ahn, Keumhee C. Carriere, Jeong-Am Ryu
    Journal of Clinical Medicine.2021; 11(1): 90.     CrossRef
  • Computed Tomography-Derived Skeletal Muscle Radiodensity Is an Early, Sensitive Marker of Age-Related Musculoskeletal Changes in Healthy Adults
    Yeon Woo Jung, Namki Hong, Joon Chae Na, Woong Kyu Han, Yumie Rhee
    Endocrinology and Metabolism.2021; 36(6): 1201.     CrossRef
Close layer
Miscellaneous
Medical Big Data Is Not Yet Available: Why We Need Realism Rather than Exaggeration
Hun-Sung Kim, Dai-Jin Kim, Kun-Ho Yoon
Endocrinol Metab. 2019;34(4):349-354.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.349
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AbstractAbstract PDFPubReader   ePub   

Most people are now familiar with the concepts of big data, deep learning, machine learning, and artificial intelligence (AI) and have a vague expectation that AI using medical big data can be used to improve the quality of medical care. However, the expectation that big data could change the field of medicine is inconsistent with the current reality. The clinical meaningfulness of the results of research using medical big data needs to be examined. Medical staff needs to be clear about the purpose of AI that utilizes medical big data and to focus on the quality of this data, rather than the quantity. Further, medical professionals should understand the necessary precautions for using medical big data, as well as its advantages. No doubt that someday, medical big data will play an essential role in healthcare; however, at present, it seems too early to actively use it in clinical practice. The field continues to work toward developing medical big data and making it appropriate for healthcare. Researchers should continue to engage in empirical research to ensure that appropriate processes are in place to empirically evaluate the results of its use in healthcare.

Citations

Citations to this article as recorded by  
  • A comparative analysis: health data protection laws in Malaysia, Saudi Arabia and EU General Data Protection Regulation (GDPR)
    Jawahitha Sarabdeen, Mohamed Mazahir Mohamed Ishak
    International Journal of Law and Management.2025; 67(1): 99.     CrossRef
  • Current status of remote collaborative care for hypertension in medically underserved areas
    Seo Yeon Baik, Kyoung Min Kim, Hakyoung Park, Jiwon Shinn, Hun-Sung Kim
    Cardiovascular Prevention and Pharmacotherapy.2024; 6(1): 33.     CrossRef
  • Prediction of Cardiovascular Complication in Patients with Newly Diagnosed Type 2 Diabetes Using an XGBoost/GRU-ODE-Bayes-Based Machine-Learning Algorithm
    Joonyub Lee, Yera Choi, Taehoon Ko, Kanghyuck Lee, Juyoung Shin, Hun-Sung Kim
    Endocrinology and Metabolism.2024; 39(1): 176.     CrossRef
  • Dark Data in Real-World Evidence: Challenges, Implications, and the Imperative of Data Literacy in Medical Research
    Hun-Sung Kim
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Development and implementation of an evidence-based biofield therapy standardized documentation tool
    Paul Guillory, Tanecia Blue, John Casken, Courtnee Nunokawa
    European Journal of Integrative Medicine.2024; 68: 102369.     CrossRef
  • Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function
    Jeonghoon Ha, Joonyub Lee, Jin Yu, Hakyoung Park, Jiwon Shinn, Seung-Hwan Lee, Jae-Hyoung Cho, Hun-Sung Kim
    The Korean Journal of Internal Medicine.2024; 39(4): 650.     CrossRef
  • Computational modeling for medical data: From data collection to knowledge discovery
    Yin Yang, Shuangbin Xu, Yifan Hong, Yantong Cai, Wenli Tang, Jiao Wang, Bairong Shen, Hui Zong, Guangchuang Yu
    The Innovation Life.2024; 2(3): 100079.     CrossRef
  • Quantitative Evaluation of the Real-World Harmonization Status of Laboratory Test Items Using External Quality Assessment Data
    Sollip Kim, Tae-Dong Jeong, Kyunghoon Lee, Jae-Woo Chung, Eun-Jung Cho, Seunghoo Lee, Sail Chun, Junghan Song, Won-Ki Min
    Annals of Laboratory Medicine.2024; 44(6): 529.     CrossRef
  • Research Trends and Hotspots of Big Data in Ophthalmology: A Bibliometric Analysis and Visualization
    Jiawei Chen, Xiang-Ling Yuan, Zhimin Liao, Wenxiang Zhu, Xiaoyu Zhou, Xuanchu Duan
    Seminars in Ophthalmology.2024; : 1.     CrossRef
  • General-purpose foundation models for increased autonomy in robot-assisted surgery
    Samuel Schmidgall, Ji Woong Kim, Alan Kuntz, Ahmed Ezzat Ghazi, Axel Krieger
    Nature Machine Intelligence.2024; 6(11): 1275.     CrossRef
  • Artificial Intelligence in the Health Sector: A Systematic Review of Key Skills for Future Health Professionals (Preprint)
    Javier Gazquez-Garcia, Carlos Luis Sánchez-Bocanegra, Jose Luis Sevillano
    JMIR Medical Education.2024;[Epub]     CrossRef
  • Long-Term Risk of Cardiovascular Disease Among Type 2 Diabetes Patients According to Average and Visit-to-Visit Variations of HbA1c Levels During the First 3 Years of Diabetes Diagnosis
    Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Comparison of cardiocerebrovascular disease incidence between angiotensin converting enzyme inhibitor and angiotensin receptor blocker users in a real-world cohort
    Suehyun Lee, Hyunah Kim, Hyeon Woo Yim, Kim Hun-Sung, Ju Han Kim
    Journal of Applied Biomedicine.2023; 21(1): 7.     CrossRef
  • Multi-Omics and Management of Follicular Carcinoma of the Thyroid
    Thifhelimbilu Emmanuel Luvhengo, Ifongo Bombil, Arian Mokhtari, Maeyane Stephens Moeng, Demetra Demetriou, Claire Sanders, Zodwa Dlamini
    Biomedicines.2023; 11(4): 1217.     CrossRef
  • Correlation analysis of cancer incidence after pravastatin treatment
    Jin Yu, Raeun Kim, Jiwon Shinn, Man Young Park, Hun-Sung Kim
    Cardiovascular Prevention and Pharmacotherapy.2023; 5(2): 61.     CrossRef
  • A New Strategy for Evaluating the Quality of Laboratory Results for Big Data Research: Using External Quality Assessment Survey Data (2010–2020)
    Eun-Jung Cho, Tae-Dong Jeong, Sollip Kim, Hyung-Doo Park, Yeo-Min Yun, Sail Chun, Won-Ki Min
    Annals of Laboratory Medicine.2023; 43(5): 425.     CrossRef
  • Weight loss and side-effects of liraglutide and lixisenatide in obesity and type 2 diabetes mellitus
    Jeongmin Lee, Raeun Kim, Min-Hee Kim, Seung-Hwan Lee, Jae-Hyoung Cho, Jung Min Lee, Sang-Ah Jang, Hun-Sung Kim
    Primary Care Diabetes.2023; 17(5): 460.     CrossRef
  • Cohort profile for development of machine learning models to predict healthcare-related adverse events (Demeter): clinical objectives, data requirements for modelling and overview of data set for 2016–2018
    Svetlana Artemova, Ursula von Schenck, Rui Fa, Daniel Stoessel, Hadiseh Nowparast Rostami, Pierre-Ephrem Madiot, Jean-Marie Januel, Daniel Pagonis, Caroline Landelle, Meghann Gallouche, Christophe Cancé, Frederic Olive, Alexandre Moreau-Gaudry, Sigurd Pri
    BMJ Open.2023; 13(8): e070929.     CrossRef
  • The Present and Future of Artificial Intelligence-Based Medical Image in Diabetes Mellitus: Focus on Analytical Methods and Limitations of Clinical Use
    Ji-Won Chun, Hun-Sung Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Construction and application on the training course of information literacy for clinical nurses
    Chao Wu, Yinjuan Zhang, Jing Wu, Linyuan Zhang, Juan Du, Lu Li, Nana Chen, Liping Zhu, Sheng Zhao, Hongjuan Lang
    BMC Medical Education.2023;[Epub]     CrossRef
  • Lightweight Histological Tumor Classification Using a Joint Sparsity-Quantization Aware Training Framework
    Dina Aboutahoun, Rami Zewail, Keiji Kimura, Mostafa I. Soliman
    IEEE Access.2023; 11: 119342.     CrossRef
  • Long-Term Cumulative Exposure to High γ-Glutamyl Transferase Levels and the Risk of Cardiovascular Disease: A Nationwide Population-Based Cohort Study
    Han-Sang Baek, Bongseong Kim, Seung-Hwan Lee, Dong-Jun Lim, Hyuk-Sang Kwon, Sang-Ah Chang, Kyungdo Han, Jae-Seung Yun
    Endocrinology and Metabolism.2023; 38(6): 770.     CrossRef
  • Comorbidity Patterns and Management in Inpatients with Endocrine Diseases by Age Groups in South Korea: Nationwide Data
    Sung-Soo Kim, Hun-Sung Kim
    Journal of Personalized Medicine.2023; 14(1): 42.     CrossRef
  • Angiotensin‐converting enzyme inhibitors versus angiotensin receptor blockers: New‐onset diabetes mellitus stratified by statin use
    Juyoung Shin, Hyunah Kim, Hyeon Woo Yim, Ju Han Kim, Suehyun Lee, Hun‐Sung Kim
    Journal of Clinical Pharmacy and Therapeutics.2022; 47(1): 97.     CrossRef
  • Physician Knowledge Base: Clinical Decision Support Systems
    Sira Kim, Eung-Hee Kim, Hun-Sung Kim
    Yonsei Medical Journal.2022; 63(1): 8.     CrossRef
  • Sodium-Glucose Cotransporter-2 Inhibitor-Related Diabetic Ketoacidosis: Accuracy Verification of Operational Definition
    Dong Yoon Kang, Hyunah Kim, SooJeong Ko, HyungMin Kim, Jiwon Shinn, Min-Gyu Kang, Sun-ju Byeon, Jeong-Hee Choi, Soo-Yong Shin, Hun-Sung Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Drug Repositioning: Exploring New Indications for Existing Drug-Disease Relationships
    Hun-Sung Kim
    Endocrinology and Metabolism.2022; 37(1): 62.     CrossRef
  • A Study on Methodologies of Drug Repositioning Using Biomedical Big Data: A Focus on Diabetes Mellitus
    Suehyun Lee, Seongwoo Jeon, Hun-Sung Kim
    Endocrinology and Metabolism.2022; 37(2): 195.     CrossRef
  • Development of a predictive model for the side effects of liraglutide
    Jiyoung Min, Jiwon Shinn, Hun-Sung Kim
    Cardiovascular Prevention and Pharmacotherapy.2022; 4(2): 87.     CrossRef
  • Understanding and Utilizing Claim Data from the Korean National Health Insurance Service (NHIS) and Health Insurance Review & Assessment (HIRA) Database for Research
    Dae-Sung Kyoung, Hun-Sung Kim
    Journal of Lipid and Atherosclerosis.2022; 11(2): 103.     CrossRef
  • The Impact of the Association between Cancer and Diabetes Mellitus on Mortality
    Sung-Soo Kim, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(7): 1099.     CrossRef
  • Development of Various Diabetes Prediction Models Using Machine Learning Techniques
    Juyoung Shin, Jaewon Kim, Chanjung Lee, Joon Young Yoon, Seyeon Kim, Seungjae Song, Hun-Sung Kim
    Diabetes & Metabolism Journal.2022; 46(4): 650.     CrossRef
  • Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
    Han-sang Baek, Ji-Yeon Park, Jin Yu, Joonyub Lee, Yeoree Yang, Jeonghoon Ha, Seung Hwan Lee, Jae Hyoung Cho, Dong-Jun Lim, Hun-Sung Kim
    Endocrinology and Metabolism.2022; 37(4): 641.     CrossRef
  • Retrospective cohort analysis comparing changes in blood glucose level and body composition according to changes in thyroid‐stimulating hormone level
    Hyunah Kim, Da Young Jung, Seung‐Hwan Lee, Jae‐Hyoung Cho, Hyeon Woo Yim, Hun‐Sung Kim
    Journal of Diabetes.2022; 14(9): 620.     CrossRef
  • Long-Term Changes in HbA1c According to Blood Glucose Control Status During the First 3 Months After Visiting a Tertiary University Hospital
    Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Medication based machine learning to identify subpopulations of pediatric hemodialysis patients in an electronic health record database
    Autumn M. McKnite, Kathleen M. Job, Raoul Nelson, Catherine M.T. Sherwin, Kevin M. Watt, Simon C. Brewer
    Informatics in Medicine Unlocked.2022; 34: 101104.     CrossRef
  • Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness
    Juyoung Shin, Joonyub Lee, Taehoon Ko, Kanghyuck Lee, Yera Choi, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(11): 1899.     CrossRef
  • A Study on Weight Loss Cause as per the Side Effect of Liraglutide
    Jin Yu, Jeongmin Lee, Seung-Hwan Lee, Jae-Hyung Cho, Hun-Sung Kim, Heng Zhou
    Cardiovascular Therapeutics.2022; 2022: 1.     CrossRef
  • Risk Classification and Subphenotyping of Acute Kidney Injury: Concepts and Methodologies
    Javier A. Neyra, Jin Chen, Sean M. Bagshaw, Jay L. Koyner
    Seminars in Nephrology.2022; 42(3): 151285.     CrossRef
  • Estimation of sodium‐glucose cotransporter 2 inhibitor–related genital and urinary tract infections via electronic medical record–based common data model
    SooJeong Ko, HyungMin Kim, Jiwon Shinn, Sun‐ju Byeon, Jeong‐Hee Choi, Hun‐Sung Kim
    Journal of Clinical Pharmacy and Therapeutics.2021; 46(4): 975.     CrossRef
  • Blood glucose levels and bodyweight change after dapagliflozin administration
    Hyunah Kim, Seung‐Hwan Lee, Hyunyong Lee, Hyeon Woo Yim, Jae‐Hyoung Cho, Kun‐Ho Yoon, Hun‐Sung Kim
    Journal of Diabetes Investigation.2021; 12(9): 1594.     CrossRef
  • Artificial intelligence in healthcare: possibilities of patent protection
    T. N. Erivantseva, Yu. V. Blokhina
    FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology.2021; 14(2): 270.     CrossRef
  • Lack of Acceptance of Digital Healthcare in the Medical Market: Addressing Old Problems Raised by Various Clinical Professionals and Developing Possible Solutions
    Jong Il Park, Hwa Young Lee, Hyunah Kim, Jisan Lee, Jiwon Shinn, Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Prospect of Artificial Intelligence Based on Electronic Medical Records
    Suehyun Lee, Hun-Sung Kim
    Journal of Lipid and Atherosclerosis.2021; 10(3): 282.     CrossRef
  • Data Pseudonymization in a Range That Does Not Affect Data Quality: Correlation with the Degree of Participation of Clinicians
    Soo-Yong Shin, Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Development of a Predictive Model for Glycated Hemoglobin Values and Analysis of the Factors Affecting It
    HyeongKyu Park, Da Young Lee, So young Park, Jiyoung Min, Jiwon Shinn, Dae Ho Lee, Soon Hyo Kwon, Hun-Sung Kim, Nan Hee Kim
    Cardiovascular Prevention and Pharmacotherapy.2021; 3(4): 106.     CrossRef
  • Modeling of Changes in Creatine Kinase after HMG-CoA Reductase Inhibitor Prescription
    Hun-Sung Kim, Jiyoung Min, Jiwon Shinn, Oak-Kee Hong, Jang-Won Son, Seong-Su Lee, Sung-Rae Kim, Soon Jib Yoo
    Cardiovascular Prevention and Pharmacotherapy.2021; 3(4): 115.     CrossRef
  • TRAINING IN BIG DATA TECHNOLOGIES OF MEDICAL UNIVERSITY STUDENTS
    K.S ITINSON
    AZIMUTH OF SCIENTIFIC RESEARCH: PEDAGOGY AND PSYCHOLOGY.2021;[Epub]     CrossRef
  • Machine Learning Applications in Endocrinology and Metabolism Research: An Overview
    Namki Hong, Heajeong Park, Yumie Rhee
    Endocrinology and Metabolism.2020; 35(1): 71.     CrossRef
  • Lessons from Use of Continuous Glucose Monitoring Systems in Digital Healthcare
    Hun-Sung Kim, Kun-Ho Yoon
    Endocrinology and Metabolism.2020; 35(3): 541.     CrossRef
  • Apprehensions about Excessive Belief in Digital Therapeutics: Points of Concern Excluding Merits
    Hun-Sung Kim
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Medical Ethics in the Era of Artificial Intelligence Based on Medical Big Data
    Hae-Ran Na, Hun-Sung Kim
    The Journal of Korean Diabetes.2020; 21(3): 126.     CrossRef
  • Machine Learning Application in Diabetes and Endocrine Disorders
    Namki Hong, Heajeong Park, Yumie Rhee
    The Journal of Korean Diabetes.2020; 21(3): 130.     CrossRef
  • Real World Data and Artificial Intelligence in Diabetology
    Kwang Joon Kim
    The Journal of Korean Diabetes.2020; 21(3): 140.     CrossRef
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Miscellaneous
Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues
Duk-Hee Lee
Endocrinol Metab. 2018;33(1):44-52.   Published online March 21, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.1.44
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AbstractAbstract PDFPubReader   ePub   

Evidence has emerged that endocrine-disrupting chemicals (EDCs) can produce adverse effects, even at low doses that are assumed safe. However, systemic reviews and meta-analyses focusing on human studies, especially of EDCs with short half-lives, have demonstrated inconsistent results. Epidemiological studies have insuperable methodological limitations, including the unpredictable net effects of mixtures, non-monotonic dose-response relationships, the non-existence of unexposed groups, and the low reliability of exposure assessment. Thus, despite increases in EDC-linked diseases, traditional epidemiological studies based on individual measurements of EDCs in bio-specimens may fail to provide consistent results. The exposome has been suggested as a promising approach to address the uncertainties surrounding human studies, but it is never free from these methodological issues. Although exposure to EDCs during critical developmental periods is a major concern, continuous exposure to EDCs during non-critical periods is also harmful. Indeed, the evolutionary aspects of epigenetic programming triggered by EDCs during development should be considered because it is a key mechanism for developmental plasticity. Presently, living without EDCs is impossible due to their omnipresence. Importantly, there are lifestyles which can increase the excretion of EDCs or mitigate their harmful effects through the activation of mitohormesis or xenohormesis. Effectiveness of lifestyle interventions should be evaluated as practical ways against EDCs in the real world.

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  • A review on optimizing photocatalytic performance for effective removal of emerging pollutants: Approaches and applications
    R. Kamalesh, A. Saravanan, Y.P. Ragini, A.S. Vickram
    Journal of Water Process Engineering.2025; 69: 106883.     CrossRef
  • Are (bio)electrochemical techniques sustainable solutions to combat micro- and nano-plastic pollution?
    Almeenu Rasheed, Yasser Bashir, Sovik Das
    Current Opinion in Chemical Engineering.2025; 47: 101091.     CrossRef
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    International Journal of Hygiene and Environmental Health.2025; 264: 114524.     CrossRef
  • Joint and interactive effects of metal mixtures on liver damage: Epidemiological evidence from repeated-measures study
    Guohuan Yin, Shuanzheng Zhao, Meiduo Zhao, Jing Xu, Xiaoyu Ge, Jingtao Wu, Yifan Zhou, Xiaolin Liu, Lanping Wei, Qun Xu
    Ecotoxicology and Environmental Safety.2024; 274: 116178.     CrossRef
  • Thyroid under siege: Unravelling the toxic impact of real-life metal mixture exposures in Wistar rats
    Đurđica Marić, Katarina Baralić, Dragana Vukelić, Ivan Milošević, Anja Nikolić, Biljana Antonijević, Danijela Đukić-Ćosić, Zorica Bulat, Michael Aschner, Aleksandra Buha Djordjevic
    Chemosphere.2024; 360: 142441.     CrossRef
  • Mitigation Strategies of Emerging Pollutants from Cosmetic Industry Effluent: A Review
    Bishal Das, Sayanee Sarkar, Sourav Paul, Ayesha Zafar, Deepika Biswas, Jigisha Roy Panda, Tamalika Chakraborty
    European Journal of Theoretical and Applied Sciences.2024; 2(3): 886.     CrossRef
  • Endocrine-Disrupting Compounds in Urban Soils of Malaysia: Occurrence, Contamination, and Impacts on Health and the Environment
    Michael Lie, Joseph Kasongo, Elias Mtui, Rubiyatno, Jovale Vincent Tongco
    Tropical Aquatic and Soil Pollution.2024;[Epub]     CrossRef
  • Reconsidering “low‐dose”—Impacts of oral estrogen exposure during preimplantation embryo development
    Meret Schmidhauser, Anna‐Katharina Hankele, Susanne E. Ulbrich
    Molecular Reproduction and Development.2023; 90(7): 445.     CrossRef
  • Simultaneous estimation of methyl paraben, propyl paraben, and Bisphenol A in the plasma of Indian pregnant women using liquid chromatography–tandem mass spectrometry
    Rajesh Pradhan, Diksha Mishra, Sunil Kumar Dubey, Rajesh Khadgawat, Garima Kachhawa, Tarang Gupta, Rajeev Taliyan
    SEPARATION SCIENCE PLUS.2023;[Epub]     CrossRef
  • Influences of key factors on river water quality in urban and rural areas: A review
    Nguyen Tuan Anh, Le Duy Can, Nguyen Thi Nhan, Britta Schmalz, Tran Le Luu
    Case Studies in Chemical and Environmental Engineering.2023; 8: 100424.     CrossRef
  • Human health risk assessment for consumption of microplastics and plasticizing substances through marine species
    Virginia Montero, Yarenis Chinchilla, Luis Gómez, Adrián Flores, Alejandro Medaglia, Rossy Guillén, Ernesto Montero
    Environmental Research.2023; 237: 116843.     CrossRef
  • Effects of postnatal exposure to phthalate, bisphenol a, triclosan, parabens, and per- and poly-fluoroalkyl substances on maternal postpartum depression and infant neurodevelopment: a korean mother-infant pair cohort study
    Ju Hee Kim, Nalae Moon, Eunsun Ji, Hyo-Bang Moon
    Environmental Science and Pollution Research.2023; 30(42): 96384.     CrossRef
  • Cadmium exposure and thyroid hormone disruption: a systematic review and meta-analysis
    Seung Min Chung, Min Cheol Chang
    Reviews on Environmental Health.2023;[Epub]     CrossRef
  • Systematic review of prenatal exposure to endocrine disrupting chemicals and autism spectrum disorder in offspring
    Salvador Marí-Bauset, Isabel Peraita-Costa, Carolina Donat-Vargas, Agustín Llopis-González, Amelia Marí-Sanchis, Juan Llopis-Morales, María Morales Suárez-Varela
    Autism.2022; 26(1): 6.     CrossRef
  • Elucidation of xenoestrogen metabolism by non-targeted, stable isotope-assisted mass spectrometry in breast cancer cells
    Mira Flasch, Christoph Bueschl, Giorgia Del Favero, Gerhard Adam, Rainer Schuhmacher, Doris Marko, Benedikt Warth
    Environment International.2022; 158: 106940.     CrossRef
  • Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption
    Margarida Lorigo, Elisa Cairrao
    Molecular Aspects of Medicine.2022; 87: 101054.     CrossRef
  • UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries
    Margarida Lorigo, Carla Quintaneiro, Luiza Breitenfeld, Elisa Cairrao
    Biomedicines.2022; 10(5): 1054.     CrossRef
  • Microbiota analysis for risk assessment: evaluation of hazardous dietary substances and its potential role on the gut microbiome variability and dysbiosis
    Klara Cerk, Margarita Aguilera‐Gómez
    EFSA Journal.2022;[Epub]     CrossRef
  • Human adrenocortical carcinoma cell line (NCI-H295R): An in vitro screening model for the assessment of endocrine disruptors’ actions on steroidogenesis with an emphasis on cell ultrastructural features
    Hana Duranova, Veronika Fialkova, Veronika Valkova, Jana Bilcikova, Lucia Olexikova, Norbert Lukac, Peter Massanyi, Zuzana Knazicka
    Acta Histochemica.2022; 124(5): 151912.     CrossRef
  • Endocrine Disrupting Compounds (Nonylphenol and Bisphenol A)–Sources, Harmfulness and Laccase-Assisted Degradation in the Aquatic Environment
    Agnieszka Gałązka, Urszula Jankiewicz
    Microorganisms.2022; 10(11): 2236.     CrossRef
  • Subacute exposure to lead promotes disruption in the thyroid gland function in male and female rats
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    Environmental Pollution.2021; 274: 115889.     CrossRef
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    Environment International.2021; 146: 106274.     CrossRef
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    Endocrinology and Metabolism.2021; 36(1): 36.     CrossRef
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    Deidre M. Mattiske, Andrew J. Pask
    Current Research in Toxicology.2021; 2: 179.     CrossRef
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  • Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review
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    International Journal of Molecular Sciences.2021; 22(9): 4807.     CrossRef
  • Microplastics in aquatic environment: Challenges and perspectives
    Aashlesha Chekkala Vivekanand, Sanjeeb Mohapatra, Vinay Kumar Tyagi
    Chemosphere.2021; 282: 131151.     CrossRef
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    Nor Zaiha Arman, Salmiati Salmiati, Azmi Aris, Mohd Razman Salim, Tasnia Hassan Nazifa, Mimi Suliza Muhamad, Marpongahtun Marpongahtun
    Water.2021; 13(22): 3258.     CrossRef
  • Effects of different influent C/N ratios on microbial community and selected estrogens removal in a sequencing batch reactor
    Bingchen Zhao, Jie Lan, Dong Chen, Linlin Li
    Desalination and Water Treatment.2021; 223: 128.     CrossRef
  • Urban-level environmental factors related to pediatric asthma
    Inês Paciência, João Cavaleiro Rufo
    Porto Biomedical Journal.2020; 5(1): e57.     CrossRef
  • Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates
    Francesco Pallotti, Marianna Pelloni, Daniele Gianfrilli, Andrea Lenzi, Francesco Lombardo, Donatella Paoli
    Journal of Clinical Medicine.2020; 9(2): 471.     CrossRef
  • Developmental instability is associated with estrogenic endocrine disruption in the Chilean native fish species, Trichomycterus areolatus
    Angéline Bertin, Gautier Damiens, Daniela Castillo, Ricardo Figueroa, Christophe Minier, Nicolas Gouin
    Science of The Total Environment.2020; 714: 136638.     CrossRef
  • Tyrosinase nanocapsule based nano-biosensor for ultrasensitive and rapid detection of bisphenol A with excellent stability in different application scenarios
    Lingxia Wu, Xianbo Lu, Kai Niu, Dhanjai, Jiping Chen
    Biosensors and Bioelectronics.2020; 165: 112407.     CrossRef
  • The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study
    Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Trace Elements in Medicine and Biology.2020; 62: 126601.     CrossRef
  • Diet: A Source of Endocrine Disruptors
    Hina Rashid, Saad S. Alqahtani, Saeed Alshahrani
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(5): 633.     CrossRef
  • Aryl-hydrocarbon receptor binding and the incidence of type 2 diabetes: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
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    Environmental Health.2020;[Epub]     CrossRef
  • Endocrinology and Metabolism Has Been Indexed in MEDLINE: A Major Achievement
    Won-Young Lee
    Endocrinology and Metabolism.2019; 34(2): 138.     CrossRef
  • Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior
    Andrea C. Gore, Krittika Krishnan, Michael P. Reilly
    Hormones and Behavior.2019; 111: 7.     CrossRef
  • Removal of Pharmaceutical Contaminants in Wastewater Using Nanomaterials: A Comprehensive Review
    Anjali Chauhan, Devendra Sillu, Shekhar Agnihotri
    Current Drug Metabolism.2019; 20(6): 483.     CrossRef
  • Endocrine Disrupting Chemicals: An Occult Mediator of Metabolic Disease
    Olga Papalou, Eleni A. Kandaraki, George Papadakis, Evanthia Diamanti-Kandarakis
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Adverse Effect of Nonylphenol on the Reproductive System in F2 Male Mice : A Qualitative Change?
    Yong-Bin Kim, Yong-Pil Cheon, Donchan Choi, Sung-Ho Lee
    Development & Reproduction.2019; 23(3): 255.     CrossRef
  • Association of serum levels of p,p’- Dichlorodiphenyldichloroethylene (DDE) with type 2 diabetes in African American and Caucasian adult men from agricultural (Delta) and non-agricultural (non-Delta) regions of Mississippi
    Edward C. Meek, Dana Dale Jones, J. Allen Crow, Robert W. Wills, William H. Cooke, Janice E. Chambers
    Journal of Toxicology and Environmental Health, Part A.2019; 82(6): 387.     CrossRef
  • UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries
    Margarida Lorigo, Carla Quintaneiro, Manuel C. Lemos, José Martinez-de-Oliveira, Luiza Breitenfeld, Elisa Cairrao
    International Journal of Molecular Sciences.2019; 20(6): 1376.     CrossRef
  • Transgenerational effects of BPA on female reproduction
    Stefania Santangeli, Claudia Consales, Francesca Pacchierotti, Hamid R. Habibi, Oliana Carnevali
    Science of The Total Environment.2019; 685: 1294.     CrossRef
  • Exposure to polybrominated biphenyl and stochastic epigenetic mutations: application of a novel epigenetic approach to environmental exposure in the Michigan polybrominated biphenyl registry
    Sarah W. Curtis, Dawayland O. Cobb, Varun Kilaru, Metrecia L. Terrell, M. Elizabeth Marder, Dana Boyd Barr, Carmen J. Marsit, Michele Marcus, Karen N. Conneely, Alicia K. Smith
    Epigenetics.2019; 14(10): 1003.     CrossRef
  • Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions
    Olubusayo Alofe, Edwina Kisanga, Salmaan H. Inayat-Hussain, Masao Fukumura, Rolando Garcia-Milian, Lalith Perera, Vasilis Vasiliou, Shannon Whirledge
    Environment International.2019; 131: 104969.     CrossRef
  • 4-Nonylphenol-Enhanced EZH2 and RNF2 Expression, H3K27me3 and H2AK119ub1 Marks Resulting in Silencing of p21 CDKN1A  
    Krishna Ghosh, Biji Chatterjee, Uma Maheswari, Mariyam Athifa, Santosh R Kanade
    Epigenomics.2019; 11(8): 899.     CrossRef
  • Sex-specific effects of blood cadmium on thyroid hormones and thyroid function status: Korean nationwide cross-sectional study
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    Journal of Trace Elements in Medicine and Biology.2019; 53: 55.     CrossRef
  • Assessment of the endocrine disrupting properties of Bisphenol AF according to the EU criteria and ECHA/EFSA guidance
    Laura Escrivá, Annika Hanberg, Johanna Zilliacus, Anna Beronius
    EFSA Journal.2019;[Epub]     CrossRef
  • Comparative assessment of endocrine disrupting compounds removal in heterotrophic and enriched nitrifying biomass
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    Chemosphere.2019; 217: 659.     CrossRef
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Miscellaneous
Quality Matters as Much as Quantity of Skeletal Muscle: Clinical Implications of Myosteatosis in Cardiometabolic Health
Hong-Kyu Kim, Chul-Hee Kim
Endocrinol Metab. 2021;36(6):1161-1174.   Published online December 28, 2021
DOI: https://doi.org/10.3803/EnM.2021.1348
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AbstractAbstract PDFPubReader   ePub   
Although age-related changes in skeletal muscles are closely associated with decreases in muscle strength and functional decline, their associations with cardiometabolic diseases in the literature are inconsistent. Such inconsistency could be explained by the fact that muscle quality—which is closely associated with fatty infiltration of the muscle (i.e., myosteatosis)—is as important as muscle quantity in cardiometabolic health. However, muscle quality has been less explored compared with muscle mass. Moreover, the standard definition of myosteatosis and its assessment methods have not been established yet. Recently, some techniques using single axial computed tomography (CT) images have been introduced and utilized in many studies, as the mass and quality of abdominal muscles could be measured opportunistically on abdominal CT scans obtained during routine clinical care. Yet, the mechanisms by which myosteatosis affect metabolic and cardiovascular health remain largely unknown. In this review, we explore the recent advances in the assessment of myosteatosis and its changes associated with aging. We also review the recent literature on the clinical implication of myosteatosis by focusing on metabolic and cardiovascular diseases. Finally, we discuss the challenges and unanswered questions that need addressing to set myosteatosis as a therapeutic target for the prevention or treatment of cardiometabolic diseases.

Citations

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  • Myosteatosis is associated with adiposity, metabolic derangements and mortality in patients with chronic kidney disease
    Alice Sabatino, Antonio C. Cordeiro, Carla M. Prado, Bengt Lindholm, Peter Stenvinkel, Carla Maria Avesani
    European Journal of Clinical Nutrition.2025;[Epub]     CrossRef
  • A CT-based Deep Learning Model for Predicting Subsequent Fracture Risk in Patients with Hip Fracture
    Yisak Kim, Young-Gon Kim, Jung-Wee Park, Byung Woo Kim, Youmin Shin, Sung Hye Kong, Jung Hee Kim, Young-Kyun Lee, Sang Wan Kim, Chan Soo Shin
    Radiology.2024;[Epub]     CrossRef
  • Myosteatosis is associated with poor survival after kidney transplantation: a large retrospective cohort validation
    Jie Chen, Yue Li, Chengjie Li, Turun Song
    Abdominal Radiology.2024; 49(4): 1210.     CrossRef
  • Fatty infiltration of gastrocnemius–soleus muscle complex: Considerations for myosteatosis rehabilitation
    Catherine Hatzantonis, Lalith Satkunam, Karyne N. Rabey, Jennifer C. Hocking, Anne M. R. Agur
    Journal of Anatomy.2024; 245(1): 50.     CrossRef
  • Muscle attenuation, not skeletal muscle index, is an independent prognostic factor for survival in gastric cancer patients with overweight and obesity
    Cheng-Le Zhuang, Hao-Fan Wu, Hao-Jie Jiang, Feng-Min Zhang, Han-Ping Shi, Zhen Yu, Xian Shen, Xiao-Lei Chen, Su-Lin Wang
    Nutrition.2024; 122: 112391.     CrossRef
  • Myosteatosis is associated with coronary artery calcification in patients with type 2 diabetes
    Fu-Peng Liu, Mu-Jie Guo, Qing Yang, Yan-Ying Li, Yan-Gang Wang, Mei Zhang
    World Journal of Diabetes.2024; 15(3): 429.     CrossRef
  • Unlocking liver health: Can tackling myosteatosis spark remission in metabolic dysfunction‐associated steatotic liver disease?
    Guillaume Henin, Audrey Loumaye, Louise Deldicque, Isabelle A. Leclercq, Nicolas Lanthier
    Liver International.2024; 44(8): 1781.     CrossRef
  • Skeletal muscle mass obtained by anthropometric equation and presence of sarcopenia in postmenopausal women
    Thaís Loureiro Felipe, Patrícia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Ben-Hur Albergaria, Geise Ferreira da Cruz, José Luiz Marques-Rocha, Valdete Regina Guandalini
    Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics.2024;[Epub]     CrossRef
  • Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies
    Kylie Heitman, Matthew S. Alexander, Christian Faul
    International Journal of Molecular Sciences.2024; 25(10): 5117.     CrossRef
  • Myosteatosis and not low muscle mass is associated with lower survival in kidney transplant recipients
    Kristoffer N.D. Huitfeldt Sola, Helena M. Genberg, Carla M. Avesani, Torkel B. Brismar
    JCSM Communications.2024; 7(2): 91.     CrossRef
  • A Computed Tomography–Based Fracture Prediction Model With Images of Vertebral Bones and Muscles by Employing Deep Learning: Development and Validation Study
    Sung Hye Kong, Wonwoo Cho, Sung Bae Park, Jaegul Choo, Jung Hee Kim, Sang Wan Kim, Chan Soo Shin
    Journal of Medical Internet Research.2024; 26: e48535.     CrossRef
  • Association between atherogenic dyslipidemia and muscle quality defined by myosteatosis
    Hwi Seung Kim, Yun Kyung Cho, Myung Jin Kim, Eun Hee Kim, Min Jung Lee, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The Correlation Between Visceral Fat Area to Skeletal Muscle Mass Ratio and Multiorgan Insulin Resistance in Chinese Population With Obesity
    Yanju Zhang, Meiyang Du, Zhouhuiling Li, Xincheng Wang, Mingxin Leng, Yaping Huang, Libin Li, Shi Zhang, Chunjun Li, Faustino R. Perez-Lopez
    International Journal of Endocrinology.2024;[Epub]     CrossRef
  • Comparative analysis of body composition using torso CT from PET/CT with bioelectrical impedance and muscle strength in healthy adults
    Dong Yun Lee, Jungsu S. Oh, Jeong Won Kim, Jae Seung Kim, Minyoung Oh, Yong-il Kim, Duk Han Ko, Sung-Jin Bae, Hong-Kyu Kim, Jin-Sook Ryu
    Scientific Reports.2024;[Epub]     CrossRef
  • Association of serum gamma-glutamyl transferase with myosteatosis assessed by muscle quality mapping using abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Joong-Yeol Park, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Clinical Imaging.2023; 93: 4.     CrossRef
  • Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
    Shi Zhang, Yaping Huang, Jing Li, Xincheng Wang, Xiaohe Wang, Minying Zhang, Yanju Zhang, Meiyang Du, Jingna Lin, Chunjun Li
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • Association between hypertension and myosteatosis evaluated by abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Hypertension Research.2023; 46(4): 845.     CrossRef
  • Epidemiological, mechanistic, and practical bases for assessment of cardiorespiratory fitness and muscle status in adults in healthcare settings
    Jaime A. Gallo-Villegas, Juan C. Calderón
    European Journal of Applied Physiology.2023; 123(5): 945.     CrossRef
  • Muscle fat infiltration in chronic kidney disease: a marker related to muscle quality, muscle strength and sarcopenia
    Carla Maria Avesani, Aline Miroski de Abreu, Heitor S. Ribeiro, Torkel B. Brismar, Peter Stenvinkel, Alice Sabatino, Bengt Lindholm
    Journal of Nephrology.2023; 36(3): 895.     CrossRef
  • IDF2022-1139 Association Between Dyslipidemia And Myosteatosis Using Visual Muscular Quality Map In Computed Tomography
    H.S. Kim, H.N. Jung, Y.K. Cho, E.H. Kim, M.J. Lee, W.J. Lee, J.Y. Park, H.K. Kim, C.H. Jung
    Diabetes Research and Clinical Practice.2023; 197: 110467.     CrossRef
  • The role of skeletal muscle mass on cardiovascular disease risk: an emerging role on modulating lipid profile
    Evangelia Damigou, Matina Kouvari, Demosthenes Panagiotakos
    Current Opinion in Cardiology.2023; 38(4): 352.     CrossRef
  • Reference values for low muscle mass and myosteatosis using tomographic muscle measurements in living kidney donors
    Lisa B. Westenberg, Marcel Zorgdrager, Tim D. A. Swaab, Marco van Londen, Stephan J. L. Bakker, Henri G. D. Leuvenink, Alain R. Viddeleer, Robert A. Pol
    Scientific Reports.2023;[Epub]     CrossRef
  • Association between sarcopenic obesity and poor muscle quality based on muscle quality map and abdominal computed tomography
    Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Joong‐Yeol Park, Woo Je Lee, Hong‐Kyu Kim, Chang Hee Jung
    Obesity.2023; 31(6): 1547.     CrossRef
  • Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
    Caterina Rosano, Anne Newman, Adam Santanasto, Xiaonan Zhu, Bret Goodpaster, Iva Miljkovic
    Journal of the American Geriatrics Society.2023; 71(9): 2759.     CrossRef
  • Evaluation of Paraspinal Muscle Degeneration on Pain Relief after Percutaneous Epidural Adhesiolysis in Patients with Degenerative Lumbar Spinal Disease
    Misun Kang, Shin Hyung Kim, Minju Jo, Hyun Eom Jung, Jungbin Bae, Hee Jung Kim
    Medicina.2023; 59(6): 1118.     CrossRef
  • Sarcopenic obesity and its relation with muscle quality and mortality in patients on chronic hemodialysis
    Alice Sabatino, Carla Maria Avesani, Giuseppe Regolisti, Marianna Adinolfi, Giuseppe Benigno, Marco Delsante, Enrico Fiaccadori, Ilaria Gandolfini
    Clinical Nutrition.2023; 42(8): 1359.     CrossRef
  • Association between computed tomography‐assessed sarcopenia and mortality in patients with anti‐neutrophil cytoplasmic antibody‐associated vasculitis
    Sung Soo Ahn, Yong‐Beom Park, Sang‐Won Lee
    International Journal of Rheumatic Diseases.2023; 26(9): 1704.     CrossRef
  • Association Between Insulin Resistance and Myosteatosis Measured by Abdominal Computed Tomography
    Myung Jin Kim, Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(12): 3100.     CrossRef
  • Association of Visceral Fat Obesity, Sarcopenia, and Myosteatosis with Non-Alcoholic Fatty Liver Disease without Obesity
    Hong-Kyu Kim, Sung-Jin Bae, Min Jung Lee, Eun Hee Kim, Hana Park, Hwi Seung Kim, Yun Kyung Cho, Chang Hee Jung, Woo Je Lee, Jaewon Choe
    Clinical and Molecular Hepatology.2023; 29(4): 987.     CrossRef
  • Different computed tomography parameters for defining myosteatosis in patients with advanced non-small cell lung cancer
    Wenyi Zhang, Jing Tang, Huiyu Tang, Lingling Xie, Jing Wang, Jinhui Wu, Ming Yang
    Clinical Nutrition.2023; 42(12): 2414.     CrossRef
  • All you need to know about sarcopenia: a short guide for an internal medicine physician in questions and answers
    G. R. Bikbavova, M. A. Livzan, D. V. Tikhonravova
    Bulletin of Siberian Medicine.2023; 22(3): 88.     CrossRef
  • Muscle Fat Content Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis in Chinese Adults
    W. Guo, X. Zhao, D. Cheng, X. Liang, M. Miao, X. Li, J. Lu, N. Xu, Shuang Hu, Qun Zhang
    The Journal of nutrition, health and aging.2023; 27(11): 960.     CrossRef
  • Body Composition Evaluation and Clinical Markers of Cardiometabolic Risk in Patients with Phenylketonuria
    Luis M. Luengo-Pérez, Mercedes Fernández-Bueso, Ana Ambrojo, Marta Guijarro, Ana Cristina Ferreira, Luís Pereira-da-Silva, André Moreira-Rosário, Ana Faria, Conceição Calhau, Anne Daly, Anita MacDonald, Júlio César Rocha
    Nutrients.2023; 15(24): 5133.     CrossRef
  • Assessment of Muscle Quantity, Quality and Function
    Bo Kyung Koo
    Journal of Obesity & Metabolic Syndrome.2022; 31(1): 9.     CrossRef
  • Influence of cross‐sectional area and fat infiltration of paraspinal muscles on analgesic efficacy of epidural steroid injection in elderly patients
    Hee Jung Kim, Miribi Rho, Kyung Bong Yoon, Minju Jo, Dong Woo Lee, Shin Hyung Kim
    Pain Practice.2022; 22(7): 621.     CrossRef
  • Sarcopenia, Obesity, Sarcopenic Obesity and Risk of Poor Nutritional Status in Polish Community-Dwelling Older People Aged 60 Years and Over
    Marika Murawiak, Roma Krzymińska-Siemaszko, Aleksandra Kaluźniak-Szymanowska, Marta Lewandowicz, Sławomir Tobis, Katarzyna Wieczorowska-Tobis, Ewa Deskur-Śmielecka
    Nutrients.2022; 14(14): 2889.     CrossRef
  • Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation
    Amedeo Lonardo, Alessandro Mantovani, Salvatore Petta, Amedeo Carraro, Christopher D. Byrne, Giovanni Targher
    Nature Reviews Endocrinology.2022; 18(10): 638.     CrossRef
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Miscellaneous
Intraoperative Parathyroid Hormone Monitoring in the Surgical Management of Sporadic Primary Hyperparathyroidism
Zahra F. Khan, John I. Lew
Endocrinol Metab. 2019;34(4):327-339.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.327
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  • 31 Crossref
AbstractAbstract PDFPubReader   ePub   

Intraoperative parathyroid hormone monitoring (IPM) has been shown to be a useful adjunct during parathyroidectomy to ensure operative success at many specialized medical centers worldwide. Using the Miami or “>50% intraoperative PTH drop” criterion, IPM confirms the complete excision of all hyperfunctioning parathyroid tissue before the operation is finished, and helps guide the surgeon to identify additional hyperfunctioning parathyroid glands that may necessitate further extensive neck exploration when intraoperative parathyroid hormone (PTH) levels do not drop sufficiently. The intraoperative PTH assay is also used to differentiate parathyroid from non-parathyroid tissues during operations using fine needle aspiration samples and to lateralize the side of the neck harboring the hypersecreting parathyroid through differential jugular venous sampling when preoperative localization studies are negative or equivocal. The use of IPM underscores the recognition and understanding of sporadic primary hyperparathyroidism (SPHPT) as a disease of function rather than form, where the surgeon is better equipped to treat such patients with quantitative instead of qualitative information for durable long-term operative success. There has been a significant paradigm shift over the last 2 decades from conventional to focused parathyroidectomy guided by IPM. This approach has proven to be a safe and rapid operation requiring minimal dissection performed in an ambulatory setting for the treatment of SPHPT.

Citations

Citations to this article as recorded by  
  • Refining the role of presurgical PET/4D‐CT in a large series of patients with primary hyperparathyroidism undergoing [18F]Fluorocholine PET/CT
    Ashjan Kaseb, Houda Benider, Giorgio Treglia, Caterina Cusumano, Darejan Bessac, Pierpaolo Trimboli, Michel Vix, Arnoldo Piccardo, Adrien Latgé, Alessio Imperiale
    European Journal of Clinical Investigation.2025;[Epub]     CrossRef
  • Intraoperative Parathyroid Hormone Kinetics are Variable: An In-Vivo Analysis
    Antoinette R. Esce, Robert G. Nicholas, Noah P. Syme, Garth T. Olson, Nathan H. Boyd
    Annals of Otology, Rhinology & Laryngology.2025; 134(2): 142.     CrossRef
  • Increase in serum parathyroid hormone level intraoperatively after parathyroidectomy for primary hyperparathyroidism
    Bassam Abboud, Christopher Abboud
    American Journal of Otolaryngology.2025; 46(2): 104598.     CrossRef
  • A >50% Intraoperative Parathyroid Hormone Level Decrease Into Normal Reference Range Predicts Complete Excision of Malignancy in Patients With Parathyroid Carcinoma
    Valerie L. Armstrong, Tanaz M. Vaghaiwalla, Cima Saghira, Cheng-Bang Chen, Yujie Wang, Johan Anantharaj, Mehmet Ackin, John I. Lew
    Journal of Surgical Research.2024; 300: 567.     CrossRef
  • Intraoperative parathyroid hormone monitoring in parathyroidectomy for hyperparathyroidism: a protocol for a network meta-analysis of diagnostic test accuracy
    Phillip Staibano, Kevin Um, Sheila Yu, Mohit Bhandari, Michael K. Gupta, Michael Au, JEM (Ted) Young, Han Zhang
    Frontiers in Surgery.2024;[Epub]     CrossRef
  • Primary Hyperparathyroidism
    Saba Kurtom, Sally E. Carty
    Surgical Clinics of North America.2024; 104(4): 799.     CrossRef
  • Characteristics, management and outcomes of primary hyperparathyroidism from 2009 to 2021: a single centre report from South Africa
    Kamal Govind, Imran M. Paruk, Ayesha A. Motala
    BMC Endocrine Disorders.2024;[Epub]     CrossRef
  • The significance of determining the Intraoperative level of parathormone during surgical treatment of hyperparathyroidism
    Stefan Janičić, Kristina Stepanović, Mia Manojlović, Dean Bjelajac, Slađana Pejaković, Milan Mirković, Dragana Tomić-Naglić, Ivana Bajkin, Tijana Ičin
    Hospital Pharmacology - International Multidisciplinary Journal.2024; 11(2): 1462.     CrossRef
  • Revolutionizing parathyroid surgery: the impact of ultrafast intraoperative parathyroid hormone monitoring on patient outcomes
    Ayush Anand, Ghomsi M.C. Nathalie, Obianuju Iheomamere Muoghallu, Prakasini Satapathy, Rakesh Kumar Sharma, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Sarvesh Rustagi, Kelechi Michael Azode
    International Journal of Surgery Open.2024; 62(4): 534.     CrossRef
  • A new approach for perioperative parathyroid hormone (PTH) measurement to establish cure in patients with primary hyperparathyroidism
    Beatrice Sperotto, Natalie Meurer, Anke Meyer, Parviz Ahmad-Nejad, Norbert Bösing, Nadine Lange, Cornelia Dotzenrath, Pier Francesco Alesina
    Langenbeck's Archives of Surgery.2024;[Epub]     CrossRef
  • Intraoperative Parathyroid Hormone Monitoring Criteria in Primary Hyperparathyroidism
    Phillip Staibano, Michael Au, Han Zhang, Sheila Yu, Winnie Liu, Jesse D. Pasternak, Xing Xing, Carolyn D. Seib, Lisa Orloff, Nhu-Tram Nguyen, Michael K. Gupta, Eric Monteiro, Sameer Parpia, Tyler McKechnie, Alex Thabane, J. E. M. (Ted) Young, Mohit Bhanda
    JAMA Otolaryngology–Head & Neck Surgery.2024;[Epub]     CrossRef
  • Parathyroidectomy for primary hyperparathyroidism: A retrospective analysis of localization, surgical characteristics, and treatment outcomes
    Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee, Jin Ho Sohn
    Asian Journal of Surgery.2023; 46(2): 788.     CrossRef
  • Magnitude of parathyroid hormone elevation in primary hyperparathyroidism: Does time of day matter?
    C. Corbin Frye, Janessa Sullivan, Sai Anusha Sanka, Jingxia Liu, L. Michael Brunt, William Gillanders, Taylor C. Brown, T.K. Pandian
    Surgery.2023; 173(3): 659.     CrossRef
  • Analysis of intraoperative laboratory measurements and imaging techniques such as Tc-99 m-MIBI SPECT/CT, 18F-fluorocholine PET/CT and ultrasound in patients operated with prediagnosis of parathyroid adenoma
    Nurullah Bilen, Mehmet Avni Gokalp, Latif Yilmaz, Alper Aytekin, Ilyas Baskonus
    Irish Journal of Medical Science (1971 -).2023; 192(4): 1695.     CrossRef
  • Intraoperative Parathyroid Hormone Monitoring Is of Limited Usefulness in Guiding Autotransplantation in Reoperative or Subtotal Parathyroidectomy for Primary Hyperparathyroidism
    Bradley A. Richards, Robert A. Vierkant, Benzon M. Dy, Trenton R. Foster, Travis J. McKenzie, Melanie L. Lyden
    The American Surgeon™.2023; 89(12): 5421.     CrossRef
  • Does 18F-Fluorocholine PET/CT add value to positive parathyroid scintigraphy in the presurgical assessment of primary hyperparathyroidism?
    Alessio Imperiale, Jacob Bani, Gianluca Bottoni, Adrien Latgé, Céline Heimburger, Ugo Catrambone, Michel Vix, Giorgio Treglia, Arnoldo Piccardo
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Intraoperative Identification of Thyroid and Parathyroid Tissues During Human Endocrine Surgery Using the MasSpec Pen
    Rachel J. DeHoog, Mary E. King, Michael F. Keating, Jialing Zhang, Marta Sans, Clara L. Feider, Kyana Y. Garza, Alena Bensussan, Anna Krieger, John Q. Lin, Sunil Badal, Elizabeth Alore, Christopher Pirko, Kirtan Brahmbhatt, Wendong Yu, Raymon Grogan, Livi
    JAMA Surgery.2023; 158(10): 1050.     CrossRef
  • A Rare Case of Recurrent Parathyroid Adenomas After Initial Parathyroidectomy
    Grant N Schalet, Luke Vincent, Carl Eguez, Gerardo Diaz, Mark S Shachner
    Cureus.2023;[Epub]     CrossRef
  • Surgical treatment of tertiary hyperparathyroidism: does one fit for all?
    Claudio Casella, Claudio Guarneri, Manuela Campanile, Xavier Adhoute, Pier Paolo Gelera, Riccardo Morandi
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Variation in parathyroid adenoma size in patients with sporadic, primary hyperparathyroidism: small gland size does not preclude single gland disease
    Sophie Dream, Tina W. F. Yen, Kara Doffek, Douglas B. Evans, Tracy S. Wang
    Langenbeck's Archives of Surgery.2022; 407(5): 2067.     CrossRef
  • Role and Recent Trend of Intraoperative Parathyroid Hormone Monitoring During Parathyroidectomy in Patients With Primary Hyperparathyroidism
    Dongbin Ahn, Ji Hye Kwak
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2022; 65(5): 253.     CrossRef
  • Parathyroid Adenoma: Rare Cause of Acute Recurrent Pancreatitis
    Shikha Mahajan, Alka Kumar, Vivek Aggarwal, Vikas Jain, Vipul Baweja, Ajay Ajmani, Diplomate CBNC, Fellow EBNM LNU
    Annals of Pediatric Gastroenterology and Hepatology.2022; 2(3-4): 9.     CrossRef
  • Long-term outcome of surgical techniques for sporadic primary hyperparathyroidism in a tertiary referral center in Belgium
    Klaas Van Den Heede, Amélie Bonheure, Nele Brusselaers, Sam Van Slycke
    Langenbeck's Archives of Surgery.2022; 407(7): 3045.     CrossRef
  • Contribution of intraoperative parathyroid hormone monitoring to the surgical success in minimal invasive parathyroidectomy
    Ismail Ethem Akgün, Mehmet Taner Ünlü, Nurcihan Aygun, Mehmet Kostek, Mehmet Uludag
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Surgery for primary hyperparathyroidism
    Murilo Catafesta das Neves, Rodrigo Oliveira Santos, Monique Nakayama Ohe
    Archives of Endocrinology and Metabolism.2022; 66(5): 678.     CrossRef
  • Використання інтраопераційного моніторингу рівня паратиреоїдного гормону в мінімально інвазивній хірургії щитоподібної та паращитоподібних залоз
    S.V. Chernyshov, A.V. Tymkiv, A.V. Vovkanych, I.I. Komisarenko
    Endokrynologia.2022; 27(4): 311.     CrossRef
  • Diagnostic Values of Intraoperative (1-84) Parathyroid Hormone Levels are Superior to Intact Parathyroid Hormone for Successful Parathyroidectomy in Patients With Chronic Kidney Disease
    Fangyan Xu, Yaoyu Huang, Ming Zeng, Lina Zhang, Wenkai Ren, Hanyang Qian, Ying Cui, Guang Yang, Wenbin Zhou, Shui Wang, Hui Huang, Huimin Chen, Yujie Xiao, Xueyan Gao, Zhanhui Gao, Jing Wang, Cuiping Liu, Jing Zhang, Baiqiao Zhao, Anning Bian, Fan Li, Hui
    Endocrine Practice.2021; 27(11): 1065.     CrossRef
  • Delayed Calcium Normalization after Successful Parathyroidectomy in Primary Hyperparathyroidism
    Iván Emilio de la Cruz Rodríguez, Elsy Sarahí García Montesinos, María Fernanda Rodríguez-Delgado, Guadalupe Vargas Ortega, Lourdes Balcázar Hernández, Victoria Mendoza Zubieta, Victor Hernández Avendaño, Baldomero González Virla, Micha�l R. Laurent
    Case Reports in Endocrinology.2021; 2021: 1.     CrossRef
  • Parathyroid Surgery
    Aditya S. Shirali, Uriel Clemente-Gutierrez, Nancy D. Perrier
    Neuroimaging Clinics of North America.2021; 31(3): 397.     CrossRef
  • Focused parathyroidectomy without intraoperative parathyroid hormone measurement in primary hyperparathyroidism: Still a valid approach?
    Shelby Holt
    Surgery.2021; 170(6): 1860.     CrossRef
  • Response to the Comment on “Risk Factors of Redo Surgery After Unilateral Focused Parathyroidectomy – Conclusions From a Comprehensive Nationwide Database of 13,247 Interventions Over 6 Years”
    Robert Caiazzo, Camille Marciniak, Francois Pattou
    Annals of Surgery.2021; 274(6): e861.     CrossRef
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Miscellaneous
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations
Yuqi Guo, Sun Wook Cho, Deepak Saxena, Xin Li
Endocrinol Metab. 2020;35(1):36-43.   Published online March 19, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.1.36
  • 9,435 View
  • 220 Download
  • 30 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   ePub   

Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory role. Taken with the fact that succinate is an intermediate metabolite in the center of mitochondrial activity, and considering its potential regulation of protein succinylation through succinyl-coenzyme A, a review on the overall multifaceted actions of succinate to discuss whether and how these actions relate to the cellular locations of succinate is much warranted. Mechanistically, it is important to consider the sources of succinate, which include somatic cellular released succinate and those produced by the microbiome, especially the gut microbiota, which is an equivalent, if not greater contributor of succinate levels in the body. Continue learning the critical roles of succinate signaling, known and unknown, in many pathophysiological conditions is important. Furthermore, studies to delineate the regulation of succinate levels and to determine how succinate elicits various types of signaling in a temporal and spatial manner are also required.

Citations

Citations to this article as recorded by  
  • Research progress on intratumoral microorganisms in renal cancer
    Jiankun Zhang, Keyuan Lou, Junpeng Chi, Jitao Wu, Xinying Fan, Yuanshan Cui
    World Journal of Urology.2025;[Epub]     CrossRef
  • Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism
    Aenne‐Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia‐Marcos, Robert Kraft, Claudia Stäubert
    The FEBS Journal.2025;[Epub]     CrossRef
  • Type 2 diabetes and succinate: unmasking an age-old molecule
    Sonia Fernández-Veledo, Anna Marsal-Beltran, Joan Vendrell
    Diabetologia.2024; 67(3): 430.     CrossRef
  • Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases
    Lixiao Hang, Ying Zhang, Zheng Zhang, Haiqiang Jiang, Lin Xia
    Cardiovascular Drugs and Therapy.2024;[Epub]     CrossRef
  • Retinoic Acid-Mediated Control of Energy Metabolism Is Essential for Lung Branching Morphogenesis
    Hugo Fernandes-Silva, Marco G. Alves, Marcia R. Garcez, Jorge Correia-Pinto, Pedro F. Oliveira, Catarina C. F. Homem, Rute S. Moura
    International Journal of Molecular Sciences.2024; 25(9): 5054.     CrossRef
  • SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes
    Joan Sabadell-Basallote, Brenno Astiarraga, Carlos Castaño, Miriam Ejarque, Maria Repollés-de-Dalmau, Ivan Quesada, Jordi Blanco, Catalina Núñez-Roa, M-Mar Rodríguez-Peña, Laia Martínez, Dario F. De Jesus, Laura Marroquí, Ramon Bosch, Eduard Montanya, Fra
    Journal of Clinical Investigation.2024;[Epub]     CrossRef
  • Exposure to Succinate Leads to Steatosis in Non-Obese Non-Alcoholic Fatty Liver Disease by Inhibiting AMPK/PPARα/FGF21-Dependent Fatty Acid Oxidation
    Hong Yang, Suye Ran, Yuxia Zhou, Qing Shi, Jiangnan Yu, Wenjuan Wang, Chengqin Sun, Dengke Li, Yue Hu, Chen Pan, Qi Yuan, Yunhuan Zhen, Qi Liu, Lingyu Song
    Journal of Agricultural and Food Chemistry.2024; 72(38): 21052.     CrossRef
  • The Tricarboxylic Acid Cycle as a Central Regulator of the Rate of Aging: Implications for Metabolic Interventions
    Jonathan M. Borkum
    Advanced Biology.2023;[Epub]     CrossRef
  • Dysregulation of metabolic pathways in pulmonary fibrosis
    Rishi Rajesh, Reham Atallah, Thomas Bärnthaler
    Pharmacology & Therapeutics.2023; 246: 108436.     CrossRef
  • Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage
    Sarah Abdullah, Michael Ghio, Aaron Cotton-Betteridge, Aditya Vinjamuri, Robert Drury, Jacob Packer, Oguz Aras, Jessica Friedman, Mardeen Karim, David Engelhardt, Emma Kosowski, Kelby Duong, Farhana Shaheen, Patrick R. McGrew, Charles T. Harris, Robert Re
    Science Advances.2023;[Epub]     CrossRef
  • Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol
    A. V. Shchulkin, P. Yu. Mylnikov, I. V. Chernykh, A. S. Esenina, E. N. Yakusheva
    Bulletin of Experimental Biology and Medicine.2023; 175(1): 54.     CrossRef
  • Complex II Biology in Aging, Health, and Disease
    Eric Goetzman, Zhenwei Gong, Bob Zhang, Radhika Muzumdar
    Antioxidants.2023; 12(7): 1477.     CrossRef
  • The Influence of the Microbiome on Urological Malignancies: A Systematic Review
    Joao G. Porto, Maria Camila Suarez Arbelaez, Brandon Pena, Archan Khandekar, Ankur Malpani, Bruno Nahar, Sanoj Punnen, Chad R. Ritch, Mark L. Gonzalgo, Dipen J. Parekh, Robert Marcovich, Hemendra N. Shah
    Cancers.2023; 15(20): 4984.     CrossRef
  • The Gut Microbiome, Metformin, and Aging
    Sri Nitya Reddy Induri, Payalben Kansara, Scott C. Thomas, Fangxi Xu, Deepak Saxena, Xin Li
    Annual Review of Pharmacology and Toxicology.2022; 62(1): 85.     CrossRef
  • Tissue- and substrate-dependent mitochondrial responses to acute hypoxia–reoxygenation stress in a marine bivalve (Crassostrea gigas )
    Linda Adzigbli, Eugene P. Sokolov, Siriluck Ponsuksili, Inna M. Sokolova
    Journal of Experimental Biology.2022;[Epub]     CrossRef
  • Acute Succinate Administration Increases Oxidative Phosphorylation and Skeletal Muscle Explosive Strength via SUCNR1
    Guli Xu, Yexian Yuan, Pei Luo, Jinping Yang, Jingjing Zhou, Canjun Zhu, Qingyan Jiang, Gang Shu
    Frontiers in Veterinary Science.2022;[Epub]     CrossRef
  • Integrated bioinformatics analysis identifies established and novel TGFβ1-regulated genes modulated by anti-fibrotic drugs
    Ava C. Wilson, Joe Chiles, Shah Ashish, Diptiman Chanda, Preeti L. Kumar, James A. Mobley, Enid R. Neptune, Victor J. Thannickal, Merry-Lynn N. McDonald
    Scientific Reports.2022;[Epub]     CrossRef
  • SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis
    Cristina Bauset, Lluis Lis-Lopez, Sandra Coll, Laura Gisbert-Ferrándiz, Dulce C. Macias-Ceja, Marta Seco-Cervera, Francisco Navarro, Juan V. Esplugues, Sara Calatayud, Dolores Ortiz-Masia, Maria D. Barrachina, Jesús Cosín-Roger
    Biomedicines.2022; 10(3): 532.     CrossRef
  • Succinate as a New Actor in Pluripotency and Early Development?
    Damien Detraux, Patricia Renard
    Metabolites.2022; 12(7): 651.     CrossRef
  • Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
    Paule Bénit, Judith Goncalves, Riyad El Khoury, Malgorzata Rak, Judith Favier, Anne-Paule Gimenez-Roqueplo, Pierre Rustin
    Biomedicines.2022; 10(8): 1788.     CrossRef
  • Aqueous, Non-Polymer-Based Perovskite Quantum Dots for Bioimaging: Conserving Fluorescence and Long-Term Stability via Simple and Robust Synthesis
    Sanjayan C G, Jyothi Mannekote Shivanna, Jessica D. Schiffman, Sakar Mohan, Srinivasa Budagumpi, R. Geetha Balakrishna
    ACS Applied Materials & Interfaces.2022; 14(34): 38471.     CrossRef
  • Targeting the succinate receptor effectively inhibits periodontitis
    Yuqi Guo, Fangxi Xu, Scott C. Thomas, Yanli Zhang, Bidisha Paul, Satish Sakilam, Sungpil Chae, Patty Li, Caleb Almeter, Angela R. Kamer, Paramjit Arora, Dana T. Graves, Deepak Saxena, Xin Li
    Cell Reports.2022; 40(12): 111389.     CrossRef
  • Gemigliptin Alleviates Succinate-Induced Hepatic Stellate Cell Activation by Ameliorating Mitochondrial Dysfunction
    Giang Nguyen, So Young Park, Dinh Vinh Do, Dae-Hee Choi, Eun-Hee Cho
    Endocrinology and Metabolism.2022; 37(6): 918.     CrossRef
  • Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1
    Reham Atallah, Andrea Olschewski, Akos Heinemann
    Biomedicines.2022; 10(12): 3089.     CrossRef
  • Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment
    Rania Najm, Mahmood Yaseen Hachim, Richard K. Kandasamy
    Cancers.2022; 14(24): 6064.     CrossRef
  • Succinate dehydrogenase inhibitors: in silico flux analysis and in vivo metabolomics investigations show no severe metabolic consequences for rats and humans
    H. Kamp, J. Wahrheit, S. Stinchcombe, T. Walk, F. Stauber, B.v. Ravenzwaay
    Food and Chemical Toxicology.2021; 150: 112085.     CrossRef
  • Can polarization of macrophage metabolism enhance cardiac regeneration?
    Connor Lantz, Amanda Becker, Edward B. Thorp
    Journal of Molecular and Cellular Cardiology.2021; 160: 87.     CrossRef
  • Ethylmethylhydroxypyridine Succinate Induces Anti-inflammatory Polarization of Microglia in the Brain of Aging Rat
    Y. I. Kirova, F. M. Shakova, T. A. Voronina
    Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology.2021; 15(4): 356.     CrossRef
  • Model systems in SDHx-related pheochromocytoma/paraganglioma
    Krisztina Takács-Vellai, Zsolt Farkas, Fanni Ősz, Gordon W. Stewart
    Cancer and Metastasis Reviews.2021; 40(4): 1177.     CrossRef
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Special Article
Miscellaneous
Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology
Jung Hee Kim, Hyun Wook Chae, Sang Ouk Chin, Cheol Ryong Ku, Kyeong Hye Park, Dong Jun Lim, Kwang Joon Kim, Jung Soo Lim, Gyuri Kim, Yun Mi Choi, Seong Hee Ahn, Min Ji Jeon, Yul Hwangbo, Ju Hee Lee, Bu Kyung Kim, Yong Jun Choi, Kyung Ae Lee, Seong-Su Moon, Hwa Young Ahn, Hoon Sung Choi, Sang Mo Hong, Dong Yeob Shin, Ji A Seo, Se Hwa Kim, Seungjoon Oh, Sung Hoon Yu, Byung Joon Kim, Choong Ho Shin, Sung-Woon Kim, Chong Hwa Kim, Eun Jig Lee
Endocrinol Metab. 2020;35(2):272-287.   Published online June 24, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.2.272
  • 12,767 View
  • 539 Download
  • 21 Web of Science
  • 25 Crossref
AbstractAbstract PDFPubReader   ePub   
Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. The dosing regimen of GH replacement therapy should be individualized, with the goal of minimizing side effects and maximizing clinical improvements. The Korean Endocrine Society and the Korean Society of Pediatric Endocrinology have developed a position statement on the diagnosis and treatment of GH deficiency. This position statement is based on a systematic review of evidence and expert opinions.

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  • Once-Weekly Somapacitan as an Alternative Management of Growth Hormone Deficiency in Prepubertal Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trial
    Ghina Tsurayya, Cut Alifiya Nazhifah, Muhammad Rahmat Pirwanja, Putri Oktaviani Zulfa, Muhammad Raihan Ramadhan Tatroman, Fajar Fakri, Muhammad Iqhrammullah
    Children.2024; 11(2): 227.     CrossRef
  • Efficacy, safety, and patient satisfaction of norditropin and sogroya in patients with growth hormone deficiency: a systematic review and meta-analysis of randomized controlled trials
    Obieda Altobaishat, Mohamed Abouzid, Mostafa Hossam El Din Moawad, Abdulrahman Sharaf, Yazan Al-Ajlouni, Tungki Pratama Umar, Abdallah Bani-salameh, Mohammad Tanashat, Omar Abdullah Bataineh, Abdulqadir J. Nashwan
    Endocrine.2024; 85(2): 545.     CrossRef
  • Growth Hormone Deficiency and Growth Hormone Stimulation Test
    胜彬 孙
    Advances in Clinical Medicine.2024; 14(06): 1587.     CrossRef
  • Clinical Management of Postoperative Growth Hormone Deficiency in Hypothalamic-Pituitary Tumors
    Pedro Iglesias
    Journal of Clinical Medicine.2024; 13(15): 4307.     CrossRef
  • Isolated Growth Hormone Deficiency
    Anastasia Ibba, Chiara Guzzetti, Lavinia Sanfilippo, Sandro Loche
    Endocrines.2024; 5(3): 341.     CrossRef
  • L‐DOPA Test in the Diagnosis of Childhood Short Stature: Evaluation of Growth Hormone Peaks Over Time
    Barbara Castelli, Rita De Santis, Simona Carrera, Marco Andrea Malanima, Salvatore De Masi, Stefano Stagi
    Endocrinology, Diabetes & Metabolism.2024;[Epub]     CrossRef
  • Hsa_circ_0002473 inhibits GH3 cell proliferation and GH secretion as a competitive endogenous RNA for has-miR-4645-3p
    Kaiyu Pan, Xiaoguang Jiang, Xiaohong Hu, Jianhua Zhan, Chengyue Zhang
    Journal of Pediatric Endocrinology and Metabolism.2024; 37(12): 1054.     CrossRef
  • Baseline Clinical Factors Associated with Cessation of Growth Hormone Therapy in Patients with Severe Growth Hormone Deficiency - Real World Evidence
    Nageswary Nadarajah, Emmanuel Ssemmondo, Shani Brooks, Remi Akinyombo, Kazeem Adeleke, Harshal Deshmukh, Thozhukat Sathyapalan
    International Journal of Endocrinology and Metabolism.2024;[Epub]     CrossRef
  • GHRH in diabetes and metabolism
    Charlotte Steenblock, Stefan R. Bornstein
    Reviews in Endocrine and Metabolic Disorders.2024;[Epub]     CrossRef
  • Cohort profile: Multicenter Networks for Ideal Outcomes of Rare Pediatric Endocrine and Metabolic Diseases in Korea (OUTSPREAD study)
    Yun Jeong Lee, Chong Kun Cheon, Junghwan Suh, Jung-Eun Moon, Moon Bae Ahn, Seong Hwan Chang, Jieun Lee, Jin Ho Choi, Minsun Kim, Han Hyuk Lim, Jaehyun Kim, Shin-Hye Kim, Hae Sang Lee, Yena Lee, Eungu Kang, Se Young Kim, Yong Hee Hong, Seung Yang, Heon-Seo
    Annals of Pediatric Endocrinology & Metabolism.2024; 29(6): 349.     CrossRef
  • Pituitary abnormalities in patients with pediatric growth hormone deficiency in a single tertiary center
    Hyeon Jun Jung, Jeong Rye Kim, Jeesuk Yu
    Annals of Pediatric Endocrinology & Metabolism.2024; 29(6): 365.     CrossRef
  • Evaluation of Adult Height in Patients with Non-Permanent Idiopathic GH Deficiency
    Agnese Murianni, Anna Lussu, Chiara Guzzetti, Anastasia Ibba, Letizia Casula, Mariacarolina Salerno, Marco Cappa, Sandro Loche
    Endocrines.2023; 4(1): 169.     CrossRef
  • The effect of hypothalamic involvement and growth hormone treatment on cardiovascular risk factors during the transition period in patients with childhood-onset craniopharyngioma
    Sang Hee Park, Yun Jeong Lee, Jung-Eun Cheon, Choong Ho Shin, Hae Woon Jung, Young Ah Lee
    Annals of Pediatric Endocrinology & Metabolism.2023; 28(2): 107.     CrossRef
  • Continuous Glucose Monitoring: A Possible Aid for Detecting Hypoglycemic Events during Insulin Tolerance Tests
    Soo Yeun Sim, Moon Bae Ahn
    Sensors.2023; 23(15): 6892.     CrossRef
  • The risk patients with AGHD have of developing CVD
    Eisha Javed, Maha Zehra, Naz Elahi
    International Journal of Cardiology Cardiovascular Risk and Prevention.2023; 19: 200221.     CrossRef
  • Diagnosis of GH Deficiency Without GH Stimulation Tests
    Anastasia Ibba, Sandro Loche
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Metabolic Impacts of Discontinuation and Resumption of Recombinant Human Growth Hormone Treatment during the Transition Period in Patients with Childhood-Onset Growth Hormone Deficiency
    Yun Jeong Lee, Yunha Choi, Han-Wook Yoo, Young Ah Lee, Choong Ho Shin, Han Saem Choi, Ho-Seong Kim, Jae Hyun Kim, Jung Eun Moon, Cheol Woo Ko, Moon Bae Ahn, Byung-Kyu Suh, Jin-Ho Choi
    Endocrinology and Metabolism.2022; 37(2): 359.     CrossRef
  • A Radiomics-Based Model with the Potential to Differentiate Growth Hormone Deficiency and Idiopathic Short Stature on Sella MRI
    Taeyoun Lee, Kyungchul Song, Beomseok Sohn, Jihwan Eom, Sung Soo Ahn, Ho-Seong Kim, Seung-Koo Lee
    Yonsei Medical Journal.2022; 63(9): 856.     CrossRef
  • Phenotypic spectrum of patients with mutations in CHD7: clinical implications of endocrinological findings
    Ja Hye Kim, Yunha Choi, Soojin Hwang, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi
    Endocrine Connections.2022;[Epub]     CrossRef
  • Immune Checkpoint Inhibitors and Endocrine Disorders: A Position Statement from the Korean Endocrine Society
    Hyemi Kwon, Eun Roh, Chang Ho Ahn, Hee Kyung Kim, Cheol Ryong Ku, Kyong Yeun Jung, Ju Hee Lee, Eun Heui Kim, Sunghwan Suh, Sangmo Hong, Jeonghoon Ha, Jun Sung Moon, Jin Hwa Kim, Mi-kyung Kim
    Endocrinology and Metabolism.2022; 37(6): 839.     CrossRef
  • Laron syndrome: clinic, diagnostics (а clinical case)
    P.M. Lіashuk, R.P. Lіashuk, N.I. Stankova, M.B. Kudina
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2022; 18(3): 193.     CrossRef
  • Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force
    Eu Jeong Ku, Kyoung Jin Kim, Jung Hee Kim, Mi Kyung Kim, Chang Ho Ahn, Kyung Ae Lee, Seung Hun Lee, You-Bin Lee, Kyeong Hye Park, Yun Mi Choi, Namki Hong, A Ram Hong, Sang-Wook Kang, Byung Kwan Park, Moon-Woo Seong, Myungshin Kim, Kyeong Cheon Jung, Chan
    Endocrinology and Metabolism.2021; 36(2): 322.     CrossRef
  • Asian Conference on Tumor Ablation Guidelines for Adrenal Tumor Ablation
    Byung Kwan Park, Masashi Fujimori, Shu-Huei Shen, Uei Pua
    Endocrinology and Metabolism.2021; 36(3): 553.     CrossRef
  • Asian Conference on Tumor Ablation guidelines for renal cell carcinoma
    Byung Kwan Park, Shu-Huei Shen, Masashi Fujimori, Yi Wang
    Investigative and Clinical Urology.2021; 62(4): 378.     CrossRef
  • Diagnosis and Treatment of Adult Growth Hormone Deficiency
    Jung Hee Kim
    The Korean Journal of Medicine.2021; 96(5): 400.     CrossRef
Close layer
Review Article
Miscellaneous
Human Immunodeficiency Virus Infection and the Endocrine System
Dana Zaid, Yona Greenman
Endocrinol Metab. 2019;34(2):95-105.   Published online May 20, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.2.95
  • 8,507 View
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  • 20 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   ePub   

In the current era of effective antiretroviral therapies (ARTs), human immunodeficiency virus (HIV) infection became a chronic disorder that requires long term follow-up. Among other medical issues, these patients may develop endocrine problems, specific to HIV infection and its treatment. The purpose of this review is to give an overview of common endocrine complications associated with HIV infection, and to propose diagnostic and therapeutic strategies. HIV can affect the endocrine system at several levels. Adrenal and gonadal dysfunction, osteoporosis with increased fracture risk, dyslipidemia with increased cardiovascular risk, are some of the endocrine disorders prevalent in HIV-infected patients that may negatively influence quality of life, and increase morbidity and mortality. While ARTs have dramatically increased life expectancy in the HIV-infected population, they are not devoid of adverse effects, including endocrine dysfunction. Physicians caring for HIV-infected patients should be knowledgeable and exercise a high index of suspicion for the diagnosis of endocrine abnormalities, and in particular be aware of those that can be life threatening. Endocrine evaluation should follow the same strategies as in the general population, including prevention, early detection, and treatment.

Citations

Citations to this article as recorded by  
  • Innovative Diagnostic Approaches and Challenges in the Management of HIV: Bridging Basic Science and Clinical Practice
    Mohd Afzal, Shagun Agarwal, Rabab H. Elshaikh, Asaad M. A. Babker, Einas Awad Ibrahim Osman, Ranjay Kumar Choudhary, Suresh Jaiswal, Farhana Zahir, Pranav Kumar Prabhakar, Anass M. Abbas, Manar G. Shalabi, Ashok Kumar Sah
    Life.2025; 15(2): 209.     CrossRef
  • Tuberculosis and diabetes mellitus comorbidity in an adult Ugandan population
    Davis Kibirige, Irene Andia-Biraro, Ronald Olum, Susan Adakun, Stella Zawedde-Muyanja, Christine Sekaggya-Wiltshire, Ivan Kimuli
    BMC Infectious Diseases.2024;[Epub]     CrossRef
  • Morphometric analysis of adrenal gland in people living with human immunodeficiency virus
    Ayşe Gül Kabakcı, Ferit Kuşcu, Ferhat Can Pişkin, Yeşim Taşova, Memduha Gülhal Bozkır
    Cukurova Medical Journal.2024; 49(1): 159.     CrossRef
  • Hypogonadism among HIV-positive men who have sex with men in Taiwan: Prevalence and associated factors
    Kuan-Yu Lin, Hsin-Yun Sun, Wang-Da Liu, Chi-Ying Lin, Ming-Jui Tsai, Yu-Chung Chuang, Hung-Yuan Li, Jou-Wei Lin, Wen-Chun Liu, Pei-Ying Wu, Ling-Ya Chen, Hsi-Yen Chang, Yu-Zhen Luo, Yi-Ting Chen, Guei-Chi Li, Shyang-Rong Shih, Chien-Ching Hung
    Journal of Microbiology, Immunology and Infection.2024; 57(5): 739.     CrossRef
  • Review of organ damage from COVID and Long COVID: a disease with a spectrum of pathology
    Andrew G. Ewing, Spela Salamon, Etheresia Pretorius, David Joffe, Greta Fox, Stephane Bilodeau, Yaneer Bar-Yam
    Medical Review.2024;[Epub]     CrossRef
  • Prevalence and correlates of hypertension, diabetes, and cancer among HIV-infected adults in Guinea: Insights for healthcare policy in Sub-Saharan Africa
    Dramé Aly, Cissé Mohamed, Jones Jeb
    Journal of AIDS and HIV Research.2024; 16(1): 9.     CrossRef
  • Cardiac tamponade in people living with HIV: a systematic review of case reports and case series
    Amirreza Keyvanfar, Hanieh Najafiarab, Sepehr Ramezani, Shabnam Tehrani
    BMC Infectious Diseases.2024;[Epub]     CrossRef
  • Effect of highly-active antiretroviral therapy on neuroendocrine regulation of immunogenesis in HIV-infected children
    B. A. Bakhmetyev, G. A. Bocharov, S. Ya. Zverev, N. S. Kalashnikova
    Russian Journal of Immunology.2024; 27(3): 723.     CrossRef
  • Low Levels of Cortisol are Associated with HIV Infection in Older People: A Hormonal Substudy in the OVER50 Cohort
    Diana Hernandez-Sanchez, Silvia Martinez-Couselo, Manel Puig-Domingo, Ana Martinez, Sandra Gonzalez, Patricia Echeverria, Anna Bonjoch, Jordi Puig, Eugenia Negredo
    Current HIV Research.2024; 22(5): 318.     CrossRef
  • Viruses and Endocrine Diseases
    Magloire Pandoua Nekoua, Cyril Debuysschere, Inès Vergez, Corentin Morvan, Chaldam Jespere Mbani, Famara Sane, Enagnon Kazali Alidjinou, Didier Hober
    Microorganisms.2023; 11(2): 361.     CrossRef
  • Assessment of adrenal cortex function in a group of HIV infected patients in sub-Saharan-Africa
    Sida Ghislaine Biwole, Boli Anne Ongmeb, Etoga Martine Claude Etoa, Charly Feutseu, Yefou Mesmin Dehayem, Mekobe Francine Mendane, Samba Esther Mbono, Armel Quentin Essomba, Manga Jean Arnaud Ndi, Moor Vicky Ama, Eugene Sobngwi, Jean Claude Mbanya
    Journal of Diabetes and Endocrinology.2023; 13(1): 1.     CrossRef
  • Newly diagnosed type 1 diabetes mellitus in a human immunodeficiency virus-infected patient with antiretroviral therapy-induced immune reconstitution inflammatory syndrome: a case report
    Min-ChunYeh, Han-Chuan Chuang, Shuen-Fu Weng, Chung-Huei Hsu, Chen-Ling Huang, Yu-Pei Lin, Yan-Yu Lin, Yu-Shan Hsieh
    BMC Infectious Diseases.2023;[Epub]     CrossRef
  • Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy
    Mohammed F. Salahuddin, Alaa N. Qrareya, Fakhri Mahdi, Emaya Moss, Nicholas S. Akins, Jing Li, Hoang V. Le, Jason J. Paris
    Journal of Neuroendocrinology.2022;[Epub]     CrossRef
  • HIV in Primary Care: Case Study of Common Chronic Comorbidities
    Melody Wilkinson, Pam Biernacki, Joyce Knestrick
    The Journal for Nurse Practitioners.2022; 18(5): 525.     CrossRef
  • The crucial role of prolactin-lactogenic hormone in Covid-19
    Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Monica Butnariu, Gaber El-Saber Batiha
    Molecular and Cellular Biochemistry.2022; 477(5): 1381.     CrossRef
  • Lower bone density and microarchitecture alterations in HIV‐infected Brazilian men aged 50 years and older are associated with estradiol levels
    Felipe P. Oliveira, Luis F. C. Lima, Francisco de Paula Paranhos Neto, Laura M. C. de Mendonça, Annie Schtscherbyna, Luiz A. A. de Lima, Branca A. Fonseca, Miguel Madeira, Ronir R. Luiz, Leonardo V. Neto, Maria L. F. Farias, Elizabeth S. Machado
    Clinical Endocrinology.2022; 97(1): 142.     CrossRef
  • The impact of dolutegravir‐based combination antiretroviral therapy on the spermatozoa and fertility parameters of men living with human immunodeficiency virus
    Edidiong N. Akang, Olufunke O. Dosumu, Ann A. Ogbenna, Utom‐obong U. Akpan, Jane C. Ezeukwu, Mayowa O. Odofin, Ademola A. Oremosu, Alani S. Akanmu
    Andrologia.2022;[Epub]     CrossRef
  • Mechanisms of Musculoskeletal Frailty in People Living with HIV
    Amy K. Nelson, G. Fiskum, C. Renn, S. Zhu, S. Kottilil, N.J. Klinedinst
    The Journal of Frailty & Aging.2022; 11(1): 83.     CrossRef
  • Toxic Metals and Non-Communicable Diseases in HIV Population: A Systematic Review
    Opeyemi M. Folorunso, Chiara Frazzoli, Ifeyinwa Chijioke-Nwauche, Beatrice Bocca, Orish E. Orisakwe
    Medicina.2021; 57(5): 492.     CrossRef
  • Propensity score matching evaluation of psychological stress and hair cortisol among people living with HIV in China
    Xu Chen, Shuaifeng Liu, Chengbo Zeng, Xiaoming Li, Shan Qiao, Riying Lv, Zhiyong Shen
    Scientific Reports.2021;[Epub]     CrossRef
  • Adrenal insufficiency in HIV/AIDS: a review
    Simon Mifsud, Zachary Gauci, Mark Gruppetta, Charles Mallia Azzopardi, Stephen Fava
    Expert Review of Endocrinology & Metabolism.2021; 16(6): 351.     CrossRef
  • REPRODUCTIVE DISORDERS AND THEIR PATHOGENETIC MECHANISMS IN WOMEN WITH HIV
    O. Ya. Leshchenko, E. V. Genich
    HIV Infection and Immunosuppressive Disorders.2020; 11(4): 20.     CrossRef
  • A case of acanthosis nigricans in a HIV-infected patient
    Alessandra Iacovelli, Ivano Mezzaroma, Marcello Di Paolo, Giuseppe Soda, Ludovica De Vincentiis, Paolo Palange
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
    Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose de Leon
    Pharmaceuticals.2020; 13(12): 439.     CrossRef
Close layer
Special Article
Miscellaneous
COVID-19 Vaccination for Endocrine Patients: A Position Statement from the Korean Endocrine Society
Cheol Ryong Ku, Kyong Yeun Jung, Chang Ho Ahn, Jun Sung Moon, Ju Hee Lee, Eun Heui Kim, Hyemi Kwon, Hee Kyung Kim, Sunghwan Suh, Sangmo Hong, Jeonghoon Ha, Eun Roh, Jin Hwa Kim, Mi-kyung Kim, the Committee of Clinical Practice Guideline of the Korean Endocrine Society
Endocrinol Metab. 2021;36(4):757-765.   Published online August 17, 2021
DOI: https://doi.org/10.3803/EnM.2021.404
  • 12,317 View
  • 429 Download
  • 20 Web of Science
  • 21 Crossref
AbstractAbstract PDFPubReader   ePub   
Since the first outbreak of coronavirus disease 2019 (COVID-19), ongoing efforts have been made to discover an efficacious vaccine against COVID-19 to combat the pandemic. In most countries, both mRNA and DNA vaccines have been administered, and their side effects have also been reported. The clinical course of COVID-19 and the effects of vaccination against COVID-19 are both influenced by patients’ health status and involve a systemic physiological response. In view of the systemic function of endocrine hormones, endocrine disorders themselves and the therapeutics used to treat them can influence the outcomes of vaccination for COVID-19. However, there are very limited data to support the development of clinical guidelines for patients with specific medical backgrounds based on large clinical trials. In the current severe circumstances of the COVID-19 pandemic, position statements made by clinical specialists are essential to provide appropriate recommendations based on both medical evidence and clinical experiences. As endocrinologists, we would like to present the medical background of COVID-19 vaccination, as well as precautions to prevent the side effects of COVID-19 vaccination in patients with specific endocrine disorders, including adrenal insufficiency, diabetes mellitus, osteoporosis, autoimmune thyroid disease, hypogonadism, and pituitary disorders.

Citations

Citations to this article as recorded by  
  • COVID-19 mRNA vaccine may trigger subacute thyroiditis
    Mehmet Sözen, Ömercan Topaloğlu, Berrin Çetinarslan, Alev Selek, Zeynep Cantürk, Emre Gezer, Damla Köksalan, Taner Bayraktaroğlu
    Human Vaccines & Immunotherapeutics.2024; 17(12): 5120.     CrossRef
  • The role of co-morbidities in the development of an AEFI after COVID-19 vaccination in a large prospective cohort with patient-reported outcomes in the Netherlands
    C. Ouaddouh, J.W. Duijster, T. Lieber, F.P.A.M. van Hunsel
    Expert Opinion on Drug Safety.2024; 23(3): 323.     CrossRef
  • Thyroid dysfunction in COVID-19
    David Tak Wai Lui, Chi Ho Lee, Yu Cho Woo, Ivan Fan Ngai Hung, Karen Siu Ling Lam
    Nature Reviews Endocrinology.2024; 20(6): 336.     CrossRef
  • Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination
    Hyeyeon Moon, Sunghwan Suh, Mi Kyoung Park
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Prior immunization status of COVID-19 patients and disease severity: A multicenter retrospective cohort study assessing the different types of immunity
    Javaria Aslam, Faisal Shahzad Khan, Muhammad Talha Haris, Hewad Hewadmal, Maryam Khalid, Mohammad Y. Alshahrani, Qurrat-ul-ain Aslam, Irrum Aneela, Urooj Zafar
    Vaccine.2023; 41(2): 598.     CrossRef
  • Mortality and Severity of Coronavirus Disease 2019 in Patients with Long-Term Glucocorticoid Therapy: A Korean Nationwide Cohort Study
    Eu Jeong Ku, Keeho Song, Kyoung Min Kim, Gi Hyeon Seo, Soon Jib Yoo
    Endocrinology and Metabolism.2023; 38(2): 253.     CrossRef
  • Pituitary Diseases and COVID-19 Outcomes in South Korea: A Nationwide Cohort Study
    Jeonghoon Ha, Kyoung Min Kim, Dong-Jun Lim, Keeho Song, Gi Hyeon Seo
    Journal of Clinical Medicine.2023; 12(14): 4799.     CrossRef
  • Inactivated SARS-CoV-2 vaccination does not disturb the clinical course of Graves’ disease: An observational cohort study
    Shichen Xu, Huixin Yu, Xian Cheng, Jing Wu, Jiandong Bao, Li Zhang
    Vaccine.2023; 41(38): 5648.     CrossRef
  • Adrenal Crisis Associated With COVID-19 Vaccination in Patients With Adrenal Insufficiency
    Yukako Kurematsu, Takako Mohri, Sadanori Okada, Yutaka Takahashi
    JCEM Case Reports.2023;[Epub]     CrossRef
  • Adverse Events Associated with COVID-19 Vaccination in Adolescents with Endocrinological Disorders: A Cross-Sectional Study
    İbrahim Mert Erbaş, İrem Ceren Erbaş, Gözde Akın Kağızmanlı, Kübra Yüksek Acinikli, Özge Besci, Korcan Demir, Ece Böber, Nurşen Belet, Ayhan Abacı
    Journal of Clinical Research in Pediatric Endocrinology.2023; 15(3): 248.     CrossRef
  • Neue Aspekte der Glukokortikoidsubstitution bei Nebennierenrindeninsuffizienz
    Tina Kienitz, Gesine Meyer
    Der Internist.2022; 63(1): 12.     CrossRef
  • Endocrine Follow-up During Post-Acute COVID-19: Practical Recommendations Based on Available Clinical Evidence
    Rimesh Pal, Ameya Joshi, Sanjay K. Bhadada, Mainak Banerjee, Suresh Vaikkakara, Satinath Mukhopadhyay
    Endocrine Practice.2022; 28(4): 425.     CrossRef
  • Safety of Inactivated and mRNA COVID-19 Vaccination Among Patients Treated for Hypothyroidism: A Population-Based Cohort Study
    Xi Xiong, Carlos King Ho Wong, Ivan Chi Ho Au, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Celine Sze Ling Chui, Esther Wai Yin Chan, Franco Wing Tak Cheng, Kristy Tsz Kwan Lau, Chi Ho Lee, Yu Cho Woo, David Tak Wai Lui, Ian Chi Kei Wong
    Thyroid.2022; 32(5): 505.     CrossRef
  • The New Entity of Subacute Thyroiditis amid the COVID-19 Pandemic: From Infection to Vaccine
    Mihaela Popescu, Adina Ghemigian, Corina Maria Vasile, Andrei Costache, Mara Carsote, Alice Elena Ghenea
    Diagnostics.2022; 12(4): 960.     CrossRef
  • Adrenal Crisis Secondary to COVID-19 Vaccination in a Patient With Hypopituitarism
    Nikolina Markovic, Anila Faizan, Chirag Boradia, Sridhar Nambi
    AACE Clinical Case Reports.2022; 8(4): 171.     CrossRef
  • The Effect of Inactivated SARS-CoV-2 Vaccines on TRAB in Graves’ Disease
    LingHong Huang, ZhengRong Jiang, JingXiong Zhou, YuPing Chen, HuiBin Huang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Osteoporosis in Patients With Respiratory Diseases
    Yue Ma, Shui Qiu, Renyi Zhou
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Pilot Findings on SARS-CoV-2 Vaccine-Induced Pituitary Diseases: A Mini Review from Diagnosis to Pathophysiology
    Ach Taieb, El Euch Mounira
    Vaccines.2022; 10(12): 2004.     CrossRef
  • Forty Years Together, New Leap Forward! The 40th Anniversary of the Korean Endocrine Society
    Jong Chul Won, Ki-Hyun Baek
    Endocrinology and Metabolism.2022; 37(6): 851.     CrossRef
  • No need of glucocorticoid dose adjustment in patients with adrenal insufficiency before COVID-19 vaccine
    Tania Pilli, Cristina Dalmiglio, Gilda Dalmazio, Alfonso Sagnella, Raffaella Forleo, Lucia Brilli, Fabio Maino, Cristina Ciuoli, Maria Grazia Castagna
    European Journal of Endocrinology.2022; 187(1): K7.     CrossRef
  • Diabetes and COVID-19 Vaccination
    Hae Dong Choi, Jun Sung Moon
    The Journal of Korean Diabetes.2021; 22(4): 221.     CrossRef
Close layer
Review Articles
Miscellaneous
Clinical Characteristics, Management, and Potential Biomarkers of Endocrine Dysfunction Induced by Immune Checkpoint Inhibitors
Shintaro Iwama, Tomoko Kobayashi, Hiroshi Arima
Endocrinol Metab. 2021;36(2):312-321.   Published online April 27, 2021
DOI: https://doi.org/10.3803/EnM.2021.1007
  • 7,117 View
  • 290 Download
  • 24 Web of Science
  • 21 Crossref
AbstractAbstract PDFPubReader   ePub   
Immune-related adverse events (irAEs) affecting the endocrine glands are among the most frequent irAEs induced by immune checkpoint inhibitors (ICIs) and include hypopituitarism, primary adrenal insufficiency, thyrotoxicosis, hypothyroidism, hypoparathyroidism, and type 1 diabetes mellitus. Since the incidence and clinical features of endocrine irAEs vary according to the ICI used, it is important to understand the characteristics of these irAEs and to manage each one appropriately. Since some endocrine irAEs, including adrenal crisis and diabetic ketoacidosis, are potentially life-threatening, predicting the risk of endocrine irAEs before their onset is critical. Several autoantibodies have been detected in patients who develop endocrine irAEs, among which anti-thyroid antibodies may be predictive biomarkers of thyroid dysfunction. In this review, we describe the clinical features of each endocrine irAE induced by ICIs and discuss their potential biomarkers, including autoantibodies.

Citations

Citations to this article as recorded by  
  • Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
    Shintaro Iwama, Tomoko Kobayashi, Hiroshi Arima
    Nature Reviews Endocrinology.2025;[Epub]     CrossRef
  • Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD⁃1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma
    Kai Shang, Qianyong He, Xinyu Xu, Xunyan Luo, Chaofen Zhao, Lina Liu, Zhuoling Li, Yuanyuan Li, Feng Jin
    Therapeutics and Clinical Risk Management.2025; Volume 21: 15.     CrossRef
  • Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events
    Tomoko Kobayashi, Shintaro Iwama, Hiroshi Arima
    Endocrine Journal.2024; 71(1): 23.     CrossRef
  • A case of rapidly progressive insulin-dependent diabetes mellitus without islet autoantibodies developed over two years after the first dose of nivolumab
    Kota Nishihama, Yuko Okano, Chisa Inoue, Kanako Maki, Kazuhito Eguchi, Soichiro Tanaka, Atsuro Takeshita, Mei Uemura, Taro Yasuma, Toshinari Suzuki, Esteban C. Gabazza, Yutaka Yano
    Diabetology International.2024; 15(3): 583.     CrossRef
  • Endocrinopathies Associated With Immune Checkpoint Inhibitor Use
    Anupam Kotwal, Randol Kennedy, Nupur Kikani, Sonali Thosani, Whitney Goldner, Afreen Shariff
    Endocrine Practice.2024; 30(6): 584.     CrossRef
  • Combined use of tyrosine kinase inhibitors with PD-(L)1 blockade increased the risk of thyroid dysfunction in PD-(L)1 blockade: a prospective study
    Tomoko Kobayashi, Shintaro Iwama, Ayana Yamagami, Tetsushi Izuchi, Koji Suzuki, Koki Otake, Yoshinori Yasuda, Masahiko Ando, Takeshi Onoue, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Tetsunari Hase, Naoki Nishio, Shoi
    Cancer Immunology, Immunotherapy.2024;[Epub]     CrossRef
  • Adrenal Insufficiency and Thyrotoxicosis Following Combined Immune Checkpoint Inhibitor Use: A Case Report and Literature Review
    Kaoruko Fukushima, Saori Kitayama, Manami Sazuka, Remi Kodera, Kazuhito Oba, Kenji Toyoshima, Yuko Chiba, Hiroshi Yamamoto, Atsushi Araki, Yoshiaki Tamura
    Cureus.2024;[Epub]     CrossRef
  • Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade
    Ayana Yamagami, Shintaro Iwama, Tomoko Kobayashi, Xin Zhou, Yoshinori Yasuda, Takayuki Okuji, Masaaki Ito, Tetsushi Izuchi, Masahiko Ando, Takeshi Onoue, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima
    Endocrine Journal.2024; 71(5): 515.     CrossRef
  • Single-cell RNA sequencing analysis of peripheral blood mononuclear cells in PD-1-induced renal toxicity in patients with lung cancer
    Shusu Liu, Peiyu Lu, Bixia Yang, Yan Yang, Hua Zhou, Min Yang
    BMC Nephrology.2024;[Epub]     CrossRef
  • Development of pituitary dysfunction and destructive thyroiditis is associated with better survival in non-small cell lung cancer patients treated with programmed cell death-1 inhibitors: a prospective study with immortal time bias correction
    Koji Suzuki, Tomoko Kobayashi, Tetsushi Izuchi, Koki Otake, Masahiko Ando, Tomoko Handa, Takashi Miyata, Mariko Sugiyama, Takeshi Onoue, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Tetsunari Hase, Megumi Inoue, Makoto Ishii, Hiroshi Arima, Shintaro Iw
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Recovery from insulin dependence in immune checkpoint inhibitor‐associated diabetes mellitus: A case report
    Marie Okubo, Yuji Hataya, Kanta Fujimoto, Toshio Iwakura, Naoki Matsuoka
    Journal of Diabetes Investigation.2023; 14(1): 147.     CrossRef
  • Case Report: A Rising Cause of New-Onset Endocrinopathies After Immunotherapy
    Charity Tan, Sarah Hendricks, Kristina Hernandez, Martha Benavides, Rupinderjit Samra
    The Journal for Nurse Practitioners.2023; 19(5): 104582.     CrossRef
  • Risk of Thyroid Dysfunction in PD-1 Blockade Is Stratified by the Pattern of TgAb and TPOAb Positivity at Baseline
    Xin Zhou, Shintaro Iwama, Tomoko Kobayashi, Masahiko Ando, Hiroshi Arima
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(10): e1056.     CrossRef
  • Severe thyrotoxicosis induced by tislelizumab: a case report and literature review
    Liman Huo, Chao Wang, Haixia Ding, Xuelian Shi, Bin Shan, Ruoying Zhou, Ping Liang, Juan Hou
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Life-Threatening Endocrinological Immune-Related Adverse Events of Immune Checkpoint Inhibitor Therapy
    Aleksandra Basek, Grzegorz K. Jakubiak, Grzegorz Cieślar, Agata Stanek
    Cancers.2023; 15(24): 5786.     CrossRef
  • Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline
    Shintaro Iwama, Tomoko Kobayashi, Yoshinori Yasuda, Takayuki Okuji, Masaaki Ito, Masahiko Ando, Xin Zhou, Ayana Yamagami, Takeshi Onoue, Yohei Kawaguchi, Takashi Miyata, Mariko Sugiyama, Hiroshi Takagi, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Tets
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(4): e1620.     CrossRef
  • Biomarkers and risk factors for the early prediction of immune-related adverse events: a review
    Ying Zhang, Xiaoling Zhang, Weiling Li, Yunyi Du, Wenqing Hu, Jun Zhao
    Human Vaccines & Immunotherapeutics.2022;[Epub]     CrossRef
  • Immune Checkpoint Inhibitors as a Threat to the Hypothalamus–Pituitary Axis: A Completed Puzzle
    Agnese Barnabei, Andrea Corsello, Rosa Maria Paragliola, Giovanni Maria Iannantuono, Luca Falzone, Salvatore Maria Corsello, Francesco Torino
    Cancers.2022; 14(4): 1057.     CrossRef
  • Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade
    Tomoko Kobayashi, Shintaro Iwama, Ayana Yamagami, Yoshinori Yasuda, Takayuki Okuji, Masaaki Ito, Xin Zhou, Masahiko Ando, Takeshi Onoue, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Tetsunari Hase, Masahiro Morise, Taka
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(10): e4115.     CrossRef
  • Preconditioning of the immune system modulates the response of papillary thyroid cancer to immune checkpoint inhibitors
    Fabiana Pani, Yoshinori Yasuda, Sylvie T Rousseau, Kevin C Bermea, Solmaz Roshanmehr, Rulin Wang, Srinivasan Yegnasubramanian, Patrizio Caturegli, Luigi Adamo
    Journal for ImmunoTherapy of Cancer.2022; 10(12): e005538.     CrossRef
  • Survival benefit of endocrine dysfunction following immune checkpoint inhibitors for nonthyroidal cancers
    Anupam Kotwal, Mabel Ryder
    Current Opinion in Endocrinology, Diabetes & Obesity.2021; 28(5): 517.     CrossRef
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Encountering COVID-19 as Endocrinologists
Eun-Jung Rhee, Jung Hee Kim, Sun Joon Moon, Won-Young Lee
Endocrinol Metab. 2020;35(2):197-205.   Published online June 23, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.2.197
  • 14,886 View
  • 304 Download
  • 15 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   ePub   
The world is entering an era of disaster and chaos due to coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. Since its first emergence in December 2019 in Wuhan, China, COVID-19 has swept through Asia and propagated throughout the world to Europe and North America. As of April 13, 1,773,084 people were infected and 111,652 people had died from COVID-19 globally, and new record levels of infection are being reported every day. Based on the data that have been amassed so far, the primary risk factors for a severe disease course or even mortality from COVID-19 are underlying diseases such as diabetes and hypertension. As the global prevalence of diabetes continues to increase, patients with endocrine diseases such as diabetes mellitus and those who are on long-term corticosteroid therapy due to adrenal insufficiency or hypopituitarism are at risk for a poor prognosis of COVID-19. As endocrinologists, we would like to briefly review the current knowledge about the relationship between COVID-19 and endocrine diseases and to discuss what we can do for the safety and health of our patients with endocrine diseases in this globally threatening situation.

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  • Recent advances in the development of multiplexed nanophotonic biosensors.
    Z.K.S. Mcotshana, L.N. Thwala, M.H.C. Tlomatsane, E. van Steen, P. Mthunzi-Kufa
    Photodiagnosis and Photodynamic Therapy.2024; 48: 104246.     CrossRef
  • Determining the frequency of thyroid involvement in chest CT scans of COVID-19 patients and its correlation with the severity of lung involvement and survival of patients in 2020
    Fatemeh Yarmahmoodi, Shoayb Samimi, Banafasheh Zeinali-Rafsanjani, Seyed Mostajab Razavinejad, Mahdi Saeedi-Moghadam
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Adverse Events Associated with COVID-19 Vaccination in Adolescents with Endocrinological Disorders: A Cross-Sectional Study
    İbrahim Mert Erbaş, İrem Ceren Erbaş, Gözde Akın Kağızmanlı, Kübra Yüksek Acinikli, Özge Besci, Korcan Demir, Ece Böber, Nurşen Belet, Ayhan Abacı
    Journal of Clinical Research in Pediatric Endocrinology.2023; 15(3): 248.     CrossRef
  • Pituitary Diseases and COVID-19 Outcomes in South Korea: A Nationwide Cohort Study
    Jeonghoon Ha, Kyoung Min Kim, Dong-Jun Lim, Keeho Song, Gi Hyeon Seo
    Journal of Clinical Medicine.2023; 12(14): 4799.     CrossRef
  • New-onset and relapsed Graves’ disease following COVID-19 vaccination: a comprehensive review of reported cases
    Kan Chen, Yiyang Gao, Jing Li
    European Journal of Medical Research.2023;[Epub]     CrossRef
  • Assessment of Neuroendocrine Changes and Hypothalamo-Pituitary Autoimmunity in Patients with COVID-19
    Mustafa Sait Gonen, Annamaria De Bellis, Emre Durcan, Giuseppe Bellastella, Paolo Cirillo, Lorenzo Scappaticcio, Miriam Longo, Basak Ecem Bircan, Serdar Sahin, Cem Sulu, Hande Mefkure Ozkaya, Dildar Konukoglu, Fatma Ferda Kartufan, Fahrettin Kelestimur
    Hormone and Metabolic Research.2022; 54(03): 153.     CrossRef
  • COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality
    Prateek Sharma, Tapan Behl, Neelam Sharma, Sukhbir Singh, Ajmer Singh Grewal, Ali Albarrati, Mohammed Albratty, Abdulkarim M. Meraya, Simona Bungau
    Biomedicine & Pharmacotherapy.2022; 151: 113089.     CrossRef
  • The Relationship between COVID-19 and Hypothalamic–Pituitary–Adrenal Axis: A Large Spectrum from Glucocorticoid Insufficiency to Excess—The CAPISCO International Expert Panel
    Mojca Jensterle, Rok Herman, Andrej Janež, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan,
    International Journal of Molecular Sciences.2022; 23(13): 7326.     CrossRef
  • WhatsApp-Based Virtual Consultation in Clinical Practice during COVID Times
    Ramakanth Bhargav Panchangam, Pradeep Puthenveetil, Sunil Kumar Kota, Sabaretnam Mayilvaganan
    Annals of African Medicine.2022; 21(2): 132.     CrossRef
  • Thyroid and COVID-19: a review on pathophysiological, clinical and organizational aspects
    G. Lisco, A. De Tullio, E. Jirillo, V. A. Giagulli, G. De Pergola, E. Guastamacchia, V. Triggiani
    Journal of Endocrinological Investigation.2021; 44(9): 1801.     CrossRef
  • Effects of a DPP-4 Inhibitor and RAS Blockade on Clinical Outcomes of Patients with Diabetes and COVID-19
    Sang Youl Rhee, Jeongwoo Lee, Hyewon Nam, Dae-Sung Kyoung, Dong Wook Shin, Dae Jung Kim
    Diabetes & Metabolism Journal.2021; 45(2): 251.     CrossRef
  • COVID-19 Vaccination for Endocrine Patients: A Position Statement from the Korean Endocrine Society
    Cheol Ryong Ku, Kyong Yeun Jung, Chang Ho Ahn, Jun Sung Moon, Ju Hee Lee, Eun Heui Kim, Hyemi Kwon, Hee Kyung Kim, Sunghwan Suh, Sangmo Hong, Jeonghoon Ha, Eun Roh, Jin Hwa Kim, Mi-kyung Kim
    Endocrinology and Metabolism.2021; 36(4): 757.     CrossRef
  • Collateral Damage of the COVID‐19 Pandemic on Nutritional Quality and Physical Activity: Perspective from South Korea
    Soo Lim, Hyunjung Lim, Jean‐Pierre Després
    Obesity.2020; 28(10): 1788.     CrossRef
  • Diabetes mellitus and COVID-19 in the post-acute phase patients - possible links with physical and rehabilitation medicine and balneotherapy
    Constantin Munteanu, Diana-Loreta PĂUN, Alina-Maria ȘUȚĂ, Simin Aysel FLORESCU, Gelu ONOSE, Mihail Hoteteu
    Balneo Research Journal.2020; 11(Vol.11, no): 350.     CrossRef
  • Managing Diabetes During the COVID-19 Pandemic
    John Doupis, Konstantinos Avramidis
    European Endocrinology.2020; 16(2): 85.     CrossRef
  • Independent Impact of Diabetes on the Severity of Coronavirus Disease 2019 in 5,307 Patients in South Korea: A Nationwide Cohort Study
    Sun Joon Moon, Eun-Jung Rhee, Jin-Hyung Jung, Kyung-Do Han, Sung-Rae Kim, Won-Young Lee, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2020; 44(5): 737.     CrossRef
  • SARS-CoV-2 (COVID-19) and the Endocrine System
    Michelle D Lundholm, Caroline Poku, Nicholas Emanuele, Mary Ann Emanuele, Norma Lopez
    Journal of the Endocrine Society.2020;[Epub]     CrossRef
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Machine Learning Applications in Endocrinology and Metabolism Research: An Overview
Namki Hong, Heajeong Park, Yumie Rhee
Endocrinol Metab. 2020;35(1):71-84.   Published online March 19, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.1.71
  • 17,307 View
  • 222 Download
  • 16 Web of Science
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   

Machine learning (ML) applications have received extensive attention in endocrinology research during the last decade. This review summarizes the basic concepts of ML and certain research topics in endocrinology and metabolism where ML principles have been actively deployed. Relevant studies are discussed to provide an overview of the methodology, main findings, and limitations of ML, with the goal of stimulating insights into future research directions. Clear, testable study hypotheses stem from unmet clinical needs, and the management of data quality (beyond a focus on quantity alone), open collaboration between clinical experts and ML engineers, the development of interpretable high-performance ML models beyond the black-box nature of some algorithms, and a creative environment are the core prerequisites for the foreseeable changes expected to be brought about by ML and artificial intelligence in the field of endocrinology and metabolism, with actual improvements in clinical practice beyond hype. Of note, endocrinologists will continue to play a central role in these developments as domain experts who can properly generate, refine, analyze, and interpret data with a combination of clinical expertise and scientific rigor.

Citations

Citations to this article as recorded by  
  • Establishment of a risk prediction model for olfactory disorders in patients with transnasal pituitary tumors by machine learning
    Min Chen, Yuxin Li, Sumei Zhou, Linbo Zou, Lei Yu, Tianfang Deng, Xian Rong, Shirong Shao, Jijun Wu
    Scientific Reports.2024;[Epub]     CrossRef
  • Application of artificial intelligence in ultrasound diagnostics of thyroid nodules
    E. A. Troshina, S. M. Zakharova, K. V. Tsyguleva, I. A. Lozhkin, D. V. Korolev, A. A. Trukhin, K. S. Zaytsev, T. V. Soldatova, A. A. Garmash
    Clinical and experimental thyroidology.2024; 20(1): 15.     CrossRef
  • Artificial Intelligence for Predicting and Diagnosing Complications of Diabetes
    Jingtong Huang, Andrea M. Yeung, David G. Armstrong, Ashley N. Battarbee, Jorge Cuadros, Juan C. Espinoza, Samantha Kleinberg, Nestoras Mathioudakis, Mark A. Swerdlow, David C. Klonoff
    Journal of Diabetes Science and Technology.2023; 17(1): 224.     CrossRef
  • Expressions of Cushing’s syndrome in multiple endocrine neoplasia type 1
    William F. Simonds
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Application of machine learning and artificial intelligence in the diagnosis and classification of polycystic ovarian syndrome: a systematic review
    Francisco J. Barrera, Ethan D.L. Brown, Amanda Rojo, Javier Obeso, Hiram Plata, Eddy P. Lincango, Nancy Terry, René Rodríguez-Gutiérrez, Janet E. Hall, Skand Shekhar
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Predictors of rituximab effect on modified Rodnan skin score in systemic sclerosis: a machine-learning analysis of the DesiReS trial
    Satoshi Ebata, Koji Oba, Kosuke Kashiwabara, Keiko Ueda, Yukari Uemura, Takeyuki Watadani, Takemichi Fukasawa, Shunsuke Miura, Asako Yoshizaki-Ogawa, Asano Yoshihide, Ayumi Yoshizaki, Shinichi Sato
    Rheumatology.2022; 61(11): 4364.     CrossRef
  • Automating and improving cardiovascular disease prediction using Machine learning and EMR data features from a regional healthcare system
    Qi Li, Alina Campan, Ai Ren, Wael E. Eid
    International Journal of Medical Informatics.2022; 163: 104786.     CrossRef
  • An Interactive Online App for Predicting Diabetes via Machine Learning from Environment-Polluting Chemical Exposure Data
    Rosy Oh, Hong Kyu Lee, Youngmi Kim Pak, Man-Suk Oh
    International Journal of Environmental Research and Public Health.2022; 19(10): 5800.     CrossRef
  • Ensemble blood glucose prediction in diabetes mellitus: A review
    M.Z. Wadghiri, A. Idri, Touria El Idrissi, Hajar Hakkoum
    Computers in Biology and Medicine.2022; 147: 105674.     CrossRef
  • The maze runner: navigating through basic kinetics to AI models of human metabolism pathology
    Arina V. Martyshina, Oksana M. Tilinova, Anastasia A. Simanova, Olga S. Knyazeva, Irina V. Dokukina
    Procedia Computer Science.2022; 213: 271.     CrossRef
  • Applications of Machine Learning in Bone and Mineral Research
    Sung Hye Kong, Chan Soo Shin
    Endocrinology and Metabolism.2021; 36(5): 928.     CrossRef
  • Facial Recognition Intensity in Disease Diagnosis Using Automatic Facial Recognition
    Danning Wu, Shi Chen, Yuelun Zhang, Huabing Zhang, Qing Wang, Jianqiang Li, Yibo Fu, Shirui Wang, Hongbo Yang, Hanze Du, Huijuan Zhu, Hui Pan, Zhen Shen
    Journal of Personalized Medicine.2021; 11(11): 1172.     CrossRef
  • The Application of Artificial Intelligence and Machine Learning in Pituitary Adenomas
    Congxin Dai, Bowen Sun, Renzhi Wang, Jun Kang
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Real World Data and Artificial Intelligence in Diabetology
    Kwang Joon Kim
    The Journal of Korean Diabetes.2020; 21(3): 140.     CrossRef
  • A Novel Detection Framework for Detecting Abnormal Human Behavior
    Chengfei Wu, Zixuan Cheng, Yi-Zhang Jiang
    Mathematical Problems in Engineering.2020; 2020: 1.     CrossRef
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Coordination of Multiple Cellular Processes by NR5A1/Nr5a1
Ken-ichirou Morohashi, Miki Inoue, Takashi Baba
Endocrinol Metab. 2020;35(4):756-764.   Published online December 23, 2020
DOI: https://doi.org/10.3803/EnM.2020.402
  • 6,621 View
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  • 13 Web of Science
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AbstractAbstract PDFPubReader   ePub   
The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to these striking phenotypes, NR5A1/Nr5a1 has the potential to reprogram cells to steroidogenic cells, endow pluripotency, and regulate cell proliferation. However, due to limited knowledge regarding NR5A1 target genes, the mechanism by which NR5A1/Nr5a1 regulates these fundamental processes has remained unknown. Recently, newlyestablished technologies have enabled the identification of NR5A1 target genes related to multiple metabolic processes, as well as the aforementioned biological processes. Considering that active cellular processes are expected to be accompanied by active metabolism, NR5A1 may act as a key factor for processes such as cell differentiation, proliferation, and survival by coordinating these processes with cellular metabolism. A complete and definite picture of the cellular processes coordinated by NR5A1/Nr5a1 could be depicted by accumulating evidence of the potential target genes through whole genome studies.

Citations

Citations to this article as recorded by  
  • Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression
    Fumiya Takahashi, Takashi Baba, Antonius Christianto, Shogo Yanai, Hyeon-Cheol Lee-Okada, Keisuke Ishiwata, Kazuhiko Nakabayashi, Kenichiro Hata, Tomohiro Ishii, Tomonobu Hasegawa, Takehiko Yokomizo, Man Ho Choi, Ken-ichirou Morohashi
    Cell Reports.2024; 43(2): 113715.     CrossRef
  • A novel heterozygous SF1/NR5A1 gene variant causes 46,XY DSD-gonadal dysgenesis with hypergonadotropic hypogonadism without adrenal insufficiency
    Luis Ramos
    Genes & Diseases.2024; 11(4): 101160.     CrossRef
  • A conserved NR5A1-responsive enhancer regulates SRY in testis-determination
    Denis Houzelstein, Caroline Eozenou, Carlos F. Lagos, Maëva Elzaiat, Joelle Bignon-Topalovic, Inma Gonzalez, Vincent Laville, Laurène Schlick, Somboon Wankanit, Prochi Madon, Jyotsna Kirtane, Arundhati Athalye, Federica Buonocore, Stéphanie Bigou, Gerard
    Nature Communications.2024;[Epub]     CrossRef
  • Testicular differentiation in 46,XX DSD: an overview of genetic causes
    Maria Tereza Martins Ferrari, Elinaelma Suelane do Nascimento Silva, Mirian Yumie Nishi, Rafael Loch Batista, Berenice Bilharinho Mendonca, Sorahia Domenice
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Role of NR5A1 Gene Mutations in Disorders of Sex Development: Molecular and Clinical Features
    Giovanni Luppino, Malgorzata Wasniewska, Roberto Coco, Giorgia Pepe, Letteria Anna Morabito, Alessandra Li Pomi, Domenico Corica, Tommaso Aversa
    Current Issues in Molecular Biology.2024; 46(5): 4519.     CrossRef
  • In silico structural features of the CgNR5A: CgDAX complex and its role in regulating gene expression of CYP target genes in Crassostrea gigas
    Theo Cardozo Brascher, Leonardo de Bortoli, Guilherme Toledo-Silva, Flávia Lucena Zacchi, Guilherme Razzera
    Chemosphere.2024; 361: 142443.     CrossRef
  • Conditional disruption of Nr5a1 directed by Sox9-Cre impairs adrenal development
    Ayako Tagami, Yayoi Ikeda, Kyoko Ishizuka, Mamiko Maekawa
    Scientific Reports.2024;[Epub]     CrossRef
  • Worldwide cohort study of 46, XY differences/disorders of sex development genetic diagnoses: geographic and ethnic differences in variants
    Chen Jiali, Peng Huifang, Jiang Yuqing, Zeng Xiantao, Jiang Hongwei
    Frontiers in Genetics.2024;[Epub]     CrossRef
  • Subunit-Specific Developmental Roles of PI3K in SF1-Expressing Cells
    My Khanh Q. Huynh, Sang Hee Lyoo, Dong Joo Yang, Yun-Hee Choi, Ki Woo Kim
    Endocrinology and Metabolism.2024; 39(5): 793.     CrossRef
  • An extragenital cell population contributes to urethra closure during mouse penis development
    Ciro Maurizio Amato, Xin Xu, Humphrey Hung-Chang Yao
    Science Advances.2024;[Epub]     CrossRef
  • Nuclear Receptor Gene Variants Underlying Disorders/Differences of Sex Development through Abnormal Testicular Development
    Atsushi Hattori, Maki Fukami
    Biomolecules.2023; 13(4): 691.     CrossRef
  • Identification of a novel class of cortisol biosynthesis inhibitors and its implications in a therapeutic strategy for hypercortisolism
    Soo Hyun Kim, Gi Hoon Son, Joo Young Seok, Sung Kook Chun, Hwayoung Yun, Jaebong Jang, Young-Ger Suh, Kyungjin Kim, Jong-Wha Jung, Sooyoung Chung
    Life Sciences.2023; 325: 121744.     CrossRef
  • Induced pluripotent stem cell line generated from a patient with differences in sex development (DSD) and multiple genetic variants including a large deletion in NR5A1
    Aisha L. Siebert, Grace B. Schwartz, Hana Kubo, Monica M. Laronda
    Stem Cell Research.2023; 71: 103154.     CrossRef
  • Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis
    Sirine Souali-Crespo, Diana Condrea, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Erwan Grandgirard, Violaine Alunni, Marie Cerciat, Matthieu Jung, Chloé Mayere, Serge Nef, Manuel Mark, Frédéric Chalmel, Norbert B. Ghyselinck
    Development.2023;[Epub]     CrossRef
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WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System
Yeonjoo Kim, Soo-Hyun Kim
Endocrinol Metab. 2020;35(3):494-506.   Published online September 8, 2020
DOI: https://doi.org/10.3803/EnM.2020.302
  • 16,556 View
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
WD40-repeat (WDR)-containing proteins constitute an evolutionarily conserved large protein family with a broad range of biological functions. In human proteome, WDR makes up one of the most abundant protein-protein interaction domains. Members of the WDR protein family play important roles in nearly all major cellular signalling pathways. Mutations of WDR proteins have been associated with various human pathologies including neurological disorders, cancer, obesity, ciliopathies and endocrine disorders. This review provides an updated overview of the biological functions of WDR proteins and their mutations found in congenital disorders. We also highlight the significant role of WDR proteins in ciliopathies and endocrine disorders. The new insights may help develop therapeutic approaches targeting WDR motifs.

Citations

Citations to this article as recorded by  
  • WDR44 Loss‐of‐Function Promoter Deletion in a Male Newborn With a Ciliopathy Phenotype
    Tam P. Sneddon, Kelly L. Gilmore, Mai Xiong, Karen E. Weck, Bradford C. Powell, Neeta L. Vora
    American Journal of Medical Genetics Part A.2025;[Epub]     CrossRef
  • Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Rheumatoid Arthritis Symptoms via Shuttling Proteins
    Lijun Wang, Fei Li, Liting Wang, Bingxing Wu, Min Du, Hua Xing, Shifeng Pan
    Journal of Proteome Research.2024; 23(4): 1298.     CrossRef
  • Cardiac tumour necrosis factor receptor-associated factor 7 mediates the ubiquitination of apoptosis signal-regulating kinase 1 and aggravates cardiac hypertrophy
    Yan Che, Yu-Ting Liu, Zhao-Peng Wang, Yi-Zhou Feng, Hong-Xia Xia, Yuan Yuan, Heng Zhou, Hong-Liang Qiu, Man-Li Hu, Sha-Sha Wang, Qi-Zhu Tang
    Cardiovascular Research.2024; 120(16): 2031.     CrossRef
  • WDR64, a testis-specific protein, is involved in the manchette and flagellum formation by interacting with ODF1
    Yunfei Zhang, Xiaowei Xing, Lihua Huang, Yuyan Su, Gang Liu, Xinxing Zhang, Youbo Yang
    Heliyon.2024; 10(19): e38263.     CrossRef
  • Bi-allelic variants in WDR47 cause a complex neurodevelopmental syndrome
    Efil Bayam, Peggy Tilly, Stephan C Collins, José Rivera Alvarez, Meghna Kannan, Lucile Tonneau, Elena Brivio, Bruno Rinaldi, Romain Lecat, Noémie Schwaller, Ludovica Cotellessa, Sateesh Maddirevula, Fabiola Monteiro, Carlos M Guardia, João Paulo Kitajima,
    EMBO Molecular Medicine.2024; 17(1): 129.     CrossRef
  • Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins
    Richard Benton, Nathaniel J Himmel
    eLife.2023;[Epub]     CrossRef
  • Changes in protein phosphorylation by insulin administration in the central nervous system of the gastropod mollusk Lymnaea stagnalis
    Junko Nakai, Kengo Namiki, Yuki Totani, Shigeki Yasumasu, Teruki Yoshimura, Takashi Aoki, Etsuro Ito
    Biophysics and Physicobiology.2023; 20(4): n/a.     CrossRef
  • Unveiling Distinct Proteomic Signatures in Complicated Crohn’s Disease That Could Predict the Disease Course
    Laura A. Lucaciu, Radu Seicean, Alina Uifălean, Maria Iacobescu, Cristina A. Iuga, Andrada Seicean
    International Journal of Molecular Sciences.2023; 24(23): 16966.     CrossRef
  • Aromatic patterns: Tryptophan aromaticity as a catalyst for the emergence of life and rise of consciousness
    Amal Alachkar
    Physics of Life Reviews.2022; 42: 93.     CrossRef
  • EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules
    Takashi Hotta, Thomas S. McAlear, Yang Yue, Takumi Higaki, Sarah E. Haynes, Alexey I. Nesvizhskii, David Sept, Kristen J. Verhey, Susanne Bechstedt, Ryoma Ohi
    Current Biology.2022; 32(18): 3898.     CrossRef
  • Susceptibility of craniofacial ciliopathies to oral cancer-A proposed research
    G Arun Kumar
    Journal of Dental Health, Oral Disorders & Therapy.2022; 13(2): 41.     CrossRef
  • A WDR47 homolog facilitates ciliogenesis by modulating intraflagellar transport
    Chun-Xue Song, Xian-Ting Zeng, Wan-Xin Zeng, Rong Liu, Xia-Jing Tong, Qian Li
    Journal of Cell Science.2022;[Epub]     CrossRef
  • Biallelic loss-of-function variants in WDR11 are associated with microcephaly and intellectual disability
    Natja Haag, Ene-Choo Tan, Matthias Begemann, Lars Buschmann, Florian Kraft, Petra Holschbach, Angeline H. M. Lai, Maggie Brett, Ganeshwaran H. Mochida, Stephanie DiTroia, Lynn Pais, Jennifer E. Neil, Muna Al-Saffar, Laila Bastaki, Christopher A. Walsh, In
    European Journal of Human Genetics.2021; 29(11): 1663.     CrossRef
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Systems Biology: A Multi-Omics Integration Approach to Metabolism and the Microbiome
Jang Won Son, Saeed Shoaie, Sunjae Lee
Endocrinol Metab. 2020;35(3):507-514.   Published online September 22, 2020
DOI: https://doi.org/10.3803/EnM.2020.303
  • 8,086 View
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AbstractAbstract PDFPubReader   ePub   
The complex and dynamic nature of human physiology, as exemplified by metabolism, has often been overlooked due to the lack of quantitative and systems approaches. Recently, systems biology approaches have pushed the boundaries of our current understanding of complex biochemical, physiological, and environmental interactions, enabling proactive medicine in the near future. From this perspective, we review how state-of-the-art computational modelling of human metabolism, i.e., genome-scale metabolic modelling, could be used to identify the metabolic footprints of diseases, to guide the design of personalized treatments, and to estimate the microbiome contributions to host metabolism. These state-of-the-art models can serve as a scaffold for integrating multi-omics data, thereby enabling the identification of signatures of dysregulated metabolism by systems approaches. For example, increased plasma mannose levels due to decreased uptake in the liver have been identified as a potential biomarker of early insulin resistance by multi-omics approaches. In addition, we also review the emerging axis of human physiology and the human microbiome, discussing its contribution to host metabolism and quantitative approaches to study its variations in individuals.

Citations

Citations to this article as recorded by  
  • A review of pharmacological mechanisms, challenges and prospects of macromolecular glycopeptides
    Ye Gao, Xiaoyi Chen, Jin-ao Duan, Ping Xiao
    International Journal of Biological Macromolecules.2025; 300: 140294.     CrossRef
  • Multiomics data integration, limitations, and prospects to reveal the metabolic activity of the coral holobiont
    Amanda Williams
    FEMS Microbiology Ecology.2024;[Epub]     CrossRef
  • When the microbiome meets One Health principle: Leading to the Holy Grail of biology and contributing to overall well‐being and social sustainability
    Yazhou Zhou, Ziying Xu, Huan Zhang, Teng Liu, Jin Zhou, Yujing Bi, Yanping Han, Yafang Tan, Jing Yuan, Ruifu Yang
    iMetaOmics.2024;[Epub]     CrossRef
  • The Future Exploring of Gut Microbiome-Immunity Interactions: From In Vivo/Vitro Models to In Silico Innovations
    Sara Bertorello, Francesco Cei, Dorian Fink, Elena Niccolai, Amedeo Amedei
    Microorganisms.2024; 12(9): 1828.     CrossRef
  • Generative Models Utilizing Padding Can Efficiently Integrate and Generate Multi-Omics Data
    Hyeon-Su Lee, Seung-Hwan Hong, Gwan-Heon Kim, Hye-Jin You, Eun-Young Lee, Jae-Hwan Jeong, Jin-Woo Ahn, June-Hyuk Kim
    AI.2024; 5(3): 1614.     CrossRef
  • Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges
    Yee Tsui, Xueqi Wu, Xi Zhang, Ye Peng, Chris Ka Pun Mok, Francis K.L. Chan, Siew C. Ng, Hein Min Tun
    Trends in Microbiology.2024;[Epub]     CrossRef
  • Using New Technologies to Analyze Gut Microbiota and Predict Cancer Risk
    Mohammad Amin Hemmati, Marzieh Monemi, Shima Asli, Sina Mohammadi, Behina Foroozanmehr, Dariush Haghmorad, Valentyn Oksenych, Majid Eslami
    Cells.2024; 13(23): 1987.     CrossRef
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