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Volume 20(3); June 2005
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Review Article
Physiological Function of G Protein-Coupled Receptors(GPCRs) and Research Trends for Orphan GPCRs.
Da Young Oh, Jae Young Seong
J Korean Endocr Soc. 2005;20(3):185-199.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.185
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  • 34 Download
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No abstract available.
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Editorial
Diagnosis of Impalpable Thyroid Nodule Detected by High-resolution Ultrasonography.
Tae Yong Kim, Won Bae Kim, Young Kee Shong
J Korean Endocr Soc. 2005;20(3):200-203.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.200
  • 1,403 View
  • 17 Download
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No abstract available.
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Original Articles
The Effects of Osteoprotegerin Polymorphism on Bone Mineral Metabolism in Korean Women with Perimenopause.
Ki Won Oh, Eun Joo Yun, Eun Jung Rhee, Won Young Lee, Ki Hyun Baek, Moo Il Kang, Cheol Young Park, Sung Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Sung Woo Park
J Korean Endocr Soc. 2005;20(3):204-215.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.204
  • 1,682 View
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AbstractAbstract PDF
BACKGROUND
Osteoprotegerin(OPG) is a recently identified cytokine, which acts as a decoy receptor for the receptor activator of the NF-kappaB ligand(RANKL), and has also been shown to be an important inhibitor of osteoclastogenesis in animal models. However, the relationship between OPG gene polymorphism and female bone stati in human populations is unclear. In this study, the relationship between OPG gene polymorphisms and bone mineral metabolism in healthy Korean women was investigated. METHODS: We observed 251 healthy women(mean age, 51.3+/-6.9 yr). The serum OPG concentrations were determined using ELISA, and the biochemical markers of bone turnover and FSH measured using standard methods. The bone mineral densities at the lumbar spine and femoral neck were measured by dual energy x-ray absorptiometry. The A163G, G209A, T245G and T950C polymorphisms of the OPG gene were analyzed by allelic discrimination using the 5 nuclease polymerase chain reaction assay. RESULTS: The lumbar spine BMD of premenopausal women was marginally decreased in the variant allele group compared to the wild type group(A163G, 0.98+/-0.14g/cm2[GG+GA] vs. 1.05+/- 0.15g/cm2[AA], P =0.070; T245G, 0.97+/-0.13g/cm2[GG+GT] vs. 1.04+/-0.15g/cm2[TT], P=0.056). In the linkage of polymorphisms A163G and T245G, the lumbar spine BMD of premenopausal women was marginally decreased in the variant allele group compared to the wild type group([AATT] vs. [AGTG+AGGG+GGTG+GGGG]: 1.04+/-0.15 vs. 0.97+/- 0.13; P=0.072). However, there were no differences in the serum OPG levels and bone turnover markers among the different genotypes. CONCLUSION: The A163G and T245G polymorphisms of the OPG gene were observed to be marginally associated with the lumbar spine BMD in healthy premenopausal Korean women, but further studies will be needed to clarify this relationship
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The Clinical Characteristics of Macroprolactinemia.
Young Ju Choi, Jun Goo Kang, Sung Yeon Kim, Eui Sil Hong, Sang Wan Kim, Chan Soo Shin, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee
J Korean Endocr Soc. 2005;20(3):216-223.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.216
  • 1,630 View
  • 21 Download
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BACKGROUND
Prolactin has been identified by gel chromatography to exist is three different forms in human serum; monomeric prolactin(molecular mass 23kDa), big prolactin (molecular mass 50~60 kDa) and big big prolactin, otherwise known as macroprolactin(molecular mass 150~170kDa). The predominance of macroprolactinemia has long been known in idiopathic hyperprolactinemic patients with maintained fertility. In recent reports, 24% of microprolactinoma patients showed no menstrual disturbances, which was suggestive of macroprolactinemia. The purpose of this study was to evaluate: (1) the frequency of macroprolactinemia among idiopathic hyperprolactinemia and prolactinoma patients, (2) the difference in the clinical characteristics between hyperprolactinemia, with and without macroprolactinemia, among idiopathic hyperprolactinemia and prolactinoma patients, and (3) the follow-up prolactin level using the bromocriptine response. METHODS: We retrospectively analyzed the clinical characteristics and prolactin levels in 43 idiopathic hyperprolactinemia and 51 prolactinoma patients with a poor bromocriptine response. Macroprolactinemia was identified by the prolactin recovery of < 40% using the polyethylene glycol(PEG) precipitation test. RESULTS: (1) Of the 43 idiopathic hyperprolactinemia and 51 prolactinoma patients, 17(39.5%) and 9(17.6%), respectively, were macroprolactinemic(P<0.05). (2) Among the idiopathic hyperprolactinemia patients, galactorrhea combined with amenorrhea was significantly less frequent (P<0.05), with the 1- and 2-year follow-up prolactin levels being significantly higher in those with macroprolactinemia than monomeric prolactinemia(P<0.05). (3) Among the prolactinoma patients, amenorrhea was significantly less frequent(P<0.05), but asymptomatic cases were more frequent in those with macroprolactinemia than monomeric prolactinemia(P <0.05). The 1- and 2-year follow-up prolactin levels were significantly higher in those with macroprolactinemia than monomeric prolactinemia(P<0.05). CONCLUSION: The screening of macroprolactinemia should be considered in idiopathic hyperprolactinemia and prolactinoma patients with a poor bromocriptine response
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The Relationship between the BRAF Mutations in Thyroid Papillary Carcinomas and the Prognostic Factors.
So Young Rha, Jun Chul Lee, Ki Hyun Kwon, Hyo Jin Lee, Koon Soon Kim, Young Suk Jo, Bon Jeong Ku, Minho Shong, Young Kun Kim, Heung Kyu Ro
J Korean Endocr Soc. 2005;20(3):224-229.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.224
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  • 5 Crossref
AbstractAbstract PDF
BACKGROUND
Thyroid cancers account for about 1% of all human malignancies, with papillary thyroid carcinomas being the most common istotype. Several investigators have recently identified the most common BRAF mutation, the T1796A transversion mutation, in 29~69% of papillary thyroid cancers. The BRAF mutation has been demonstrated as a novel prognostic biomarker for the prediction of poor clinicopathological outcomes, such as increased incidence of extrathyroid invasion and distant metastasis of the tumor. In this study, we investigated the prevalence of the BRAF mutation of thyroid tissues obtained by a thyroidectomy, and its correlation with the clinicopathological outcomes. METHODS: We studied 36 thyroid tissues obtained from 24 women and 12 men by thyroidectomies, including 30 papillary carcinomas, 3 follicular carcinomas, 1 medullary carcinoma and 2 nodular hyperplasia. The mutation was sought in all specimens using DNA sequencing. RESULTS: We studied the BRAF exon 15 T1796A in these 36 thyroid tissues. The mean age at surgery was 46.6, ranging from 18 to 72 years, with a median tumor size of 2.79, ranging from 1.5 to 4.5cm. At the time of diagnosis, 27 of the 34 patients presented with some kind of extrathyroidal invasion of the tumor, and 16 had lymph node metastases. 16, 2 and 16 patients were in stages I, II and III, respectively. There was no distant metastasis. A missense mutation was found at T1796A in exon 15 in 21 of the 30 papillary carcinomas(70%). The other thyroid diseases, including the 3 follicular carcinomas, 1 medullary carcinoma and 2 nodular hyperplasia show no exon 15 T1759A transversion mutation. No statistically significant association was found between the BRAF mutations and clinicopathological characteristics of papillary carcinomas. CONCLUSION: The BRAF mutation is a important genetic alteration, with a high prevalence in papillary thyroid carcinomas. However, there was no significant association between the BRAF mutation and any of the clinicopathological factors. Further, large scale studies will be needed to evaluate the correlation between the BRAF mutation and the clinicopathological factors

Citations

Citations to this article as recorded by  
  • Detection of Plasma BRAFV600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas
    Bo Hyun Kim, In Joo Kim, Byung Joo Lee, Jin Choon Lee, In Suk Kim, Seong-Jang Kim, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim
    Yonsei Medical Journal.2015; 56(3): 634.     CrossRef
  • Diagnostic Effectiveness of PCR-based Tests DetectingBRAFMutation for Treating Malignant Melanoma: A Systematic Review
    Hae-Won Shin, Ryeo-Jin Ko, Min Lee, Hee-Young Bang, Kye-Chul Kwon, Jong-Woo Park, Sun-Hoe Koo
    Laboratory Medicine Online.2014; 4(4): 203.     CrossRef
  • BRAFV600E mutation does not serve as a prognostic factor in Korean patients with papillary thyroid carcinoma
    Dongbin Ahn, June Sik Park, Jin Ho Sohn, Jae Hyug Kim, Sun-Kyun Park, An Na Seo, Ji Young Park
    Auris Nasus Larynx.2012; 39(2): 198.     CrossRef
  • The Frequency ofBRAFMutation in Very Small Papillary Thyroid Carcinomas
    Taeeun Kim, Ji-Hyun Roh, Hee-Jung Park, Jee Eun Kwon, So-Young Kang, Yoon-La Choi, Young Lyun Oh
    The Korean Journal of Pathology.2010; 44(3): 308.     CrossRef
  • ras Mutation in Korean Papillary Thyroid Carcinomas
    Jung Hwa Jung, Keun-Sook Kim, Tae Sik Jung, Young Lyun Oh, Hye Won Jang, Hye Seung Jung, Yong-Ki Min, Myung-Shik Lee, Moon-Kyu Lee, Kwang-Won Kim, Jae Hoon Chung
    Journal of Korean Endocrine Society.2007; 22(3): 203.     CrossRef
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Mechanism of Castration-induced Apoptosis of Ventral Prostate in Rat.
Chung Park, Jong Il Park, Eun Jin Yun, Kyoung Sub Song, Jong Seok Kim, Young Rae Kim, Sang Do Lee, Seung Keil Park, Byung Doo Hwang, Kyu Lim
J Korean Endocr Soc. 2005;20(3):230-241.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.230
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BACKGROUND
S: Castration-induced androgen deprivation triggers a sequence of events, which activates apoptotic cell death of the androgen-dependent epithelial cells within the rat ventral prostate. To investigate the mechanism of castration-dependent apoptosis in the rat ventral prostate, the regulation of apoptosis-related genes was been investigated. METHODS: Azaline B was subcutaneously injected into Sprague-Dawley rat. The Fas receptor (Fas), Fas ligand (FasL) and bcl-2 mRNA, as well as the protein levels were detected by RT-PCR and Western blot analyses. Azaline B-dependent apoptosis was determined using TUNEL and a DNA fragmentation assay. The transacting factor of the FasL promoter was identified by DNA footprinting and a DNA mobility shift assay. RESULTS: The rat prostate was regressed after castration, with and the involuted ventral prostate regenerated by testosterone pretreatment, but not by that with FSH. Apoptosis of the ventral prostate was detected, after castration, using toluidine blue staining, a TUNEL assay and an apoptotic DNA fragmentation assay. The levels of Fas, FasL mRNA and protein were increased after castration. In the DNase I footprinting assay, using the FasL promoter and a nuclear extract prepared from a control prostate, at least two sites were protected: the SP-1 binding site at -283 bp and the prostate-unidentified factor(P-UF) binding site at -247 bp. The SP-1 binding activity vanished in the nuclear extract prepared from castrated rats. In the DNA mobility shift assay, the SP-1 binding activity was slightly decreased after castration. Both the Bcl-2 mRNA and Bcl-2 protein were downregulated after castration. CONCLUSION: These results suggest that the Fas/FasL system and Bcl-2 may be important to castrationdependent apoptosis in the rat ventral prostate, with SP-1 related to the castration-dependent regulation of the FasL gene
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The Usefulness of High Resolution Ultrasonography in the Differentiation of Thyroid Nodule.
Hyun Dae Yoon, Ho Sang Shon
J Korean Endocr Soc. 2005;20(3):242-251.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.242
  • 1,701 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Fine needle aspiration(FNA) is regarded as the best procedure in the diagnosis of thyroid malignancies. However, the rate of false negative and indeterminate results are between 5~10 and 10~30%, respectively. Therefore, a new diagnostic tool to assist FNA is required. Recently, high resolution ultrasonography(US) has become a useful tool in the detection of malignant thyroid nodules. Therefore, the sonographic characteristics differentiating malignant from benign nodules were analyzed, and the usefulness of US in the diagnosis of thyroid malignancy assessed. METHODS: Of the 212 patients that underwent surgery due to a thyroid nodule, at the Daegu Catholic University Hospital between January 2002 and June 2004, and 181 patients(199 nodules) who underwent high resolution US examination before surgery, were included in this study. The characteristics of the sonographic parameters, such as depth/width ratio, shape, margin, structure, sponge sign, calcification and halo, and the homogeneity and echogenicity of the solid component and invasion, were observed. RESULTS: In a univariate analysis of the nonfollicular neoplasms, the depth/width ratio, shape, margin, structure, calcification and halo, and the homogeneity and echogenicity of the solid component were found to be significant parameters. The "sponge sign", a new parameter suggested by us, was found only in benign nodules. In a multiple logistic regression analysis, only the depth/width ratio, shape, presence of calcification and echogenicity of the solid component were significant parameters. According to the results of the multiple logistic regression analysis, the point and estimate of each characteristic of the significant parameters were found, and a formula for calculating a score for the prediction of malignancy computed. At a score of 0.44, the sensitivity and specificity of US were 85.9 and 88.7%, respectively. In a univariate analysis of follicular neop-lasms, the shape, calcification and echogenicity were found to be significant parameters. CONCLUSION: It was conclude that high resolution US is a very useful tool in the differentiation of benign and malignant nodules, especially in nonfollicular neoplasms. It is also suggested that the "sponge sign" might be used as a strong indicator for the confirmation of benign nodules

Citations

Citations to this article as recorded by  
  • Effectiveness of Suppressive Therapy with Levothyroxine in Benign Thyroid Nodules
    Yun Jeong Kim, Kyung Tae, Seok Young Kang, Yong Seop Lee, Dong Sun Kim, Tae Hwa Kim, You Hern Ahn
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2009; 52(8): 674.     CrossRef
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The Effects on Visceral Fat and Cardiovascular Risk Factors of Testosterone Replacement in Secondary Hypogonadal Men.
Eui Sil Hong, Sung Yeon Kim, Young Ju Choi, Sang Wan Kim, Chan Soo Shin, Kyong Soo Park, Hak Chul Jang, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee
J Korean Endocr Soc. 2005;20(3):252-260.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.252
  • 1,826 View
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  • 4 Crossref
AbstractAbstract PDF
BACKGROUND
Increased body fat, abdominal obesity and insulin resistance are important clinical features in hypogonadal men. Several studies have demonstrated that a low testosterone concentration in men is associated with coronary heart disease, visceral obesity and insulin resistance. In this study, the effects of testosterone replacement therapy on the abdominal visceral fat and cardiovascular risk factors in hypogonadal men were investigated. METHODS: We selected 26 men with secondary hypogonadism (mean serum testosterone+/-SD 0.39+/- 0.57ng/mL), who were then treated with testosterone for 12 months. We measured the body composition, including the abdominal visceral fat area by abdominal CT at the L4 level, both before and 12 months after treatment, and the lipid profile, fasting plasma insulin, HOMA-IR and the serum homocysteine, CRP and IL-6 before and 6, 12 months after treatment. RESULTS: With respect to the body composition, the lean body mass had significantly increased 12 months after treatment(P= 0.002), but there were no significant changes in the body fat mass and abdominal visceral fat area. There was a trend toward a decreased fasting plasma insulin and HOMA-IR, but this did not reach statistical significance. The total cholesterol had decreased significantly at 12 months(P=0.04) and the HDL cholesterol decreased significantly over the course of study(P=0.02). There were no significant changes in the serum homocysteine, CRP and IL-6 after treatment. CONCLUSIONS: After 12 months testosterone replacement therapy in the 26 men with hypogonadism, the lean body mass had increased significantly, but there was no significant change on the abdominal visceral fat during the treatment period. Testosterone replacement had deleterious effect on HDL cholesterol, but not significant effects on insulin resistance and the serum homocysteine, CRP and IL-6. These results suggest that testosterone replacement therapy may have a few adverse effects on cardiovascular diseases in hypogonadal men. However, it will be necessary to examine the long-term effects of testosterone replacement on the incidence of cardiovascular events as well as the cardiovascular risk factors in men with hypogonadism

Citations

Citations to this article as recorded by  
  • The Association of Level of Testosterone and Parameters of Obesity
    Chong Hwa Kim
    The Korean Journal of Obesity.2015; 24(1): 28.     CrossRef
  • The Relationship between Various Obesity Indices and Level of Male Hormone according to Different Age Groups
    Yoo-Jung Lee, Hyeon-Ju Kim, Mi-Hee Kong
    The Korean Journal of Obesity.2014; 23(4): 245.     CrossRef
  • Androgen Receptor Gene CAG Repeat Polymorphism and Effect of Testosterone Therapy in Hypogonadal Men in Korea
    Min Joo Kim, Jin Taek Kim, Sun Wook Cho, Sang Wan Kim, Chan Soo Shin, Kyong Soo Park, Seong Yeon Kim
    Endocrinology and Metabolism.2011; 26(3): 225.     CrossRef
  • Effects of Androgen on the Cardiovascular System in the Aging Male
    Jin Wook Kim, Je Jong Kim, Du Geon Moon
    Korean Journal of Andrology.2011; 29(1): 10.     CrossRef
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Case Reports
The Change of Thyroid Hormone by Short-term Antithyroid Drug Treatment for Preoperative Euthyroidism in TSH-secreting Pituitary Adenoma.
Min Hee Lee, Ji Hyun Park
J Korean Endocr Soc. 2005;20(3):261-267.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.261
  • 1,645 View
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AbstractAbstract PDF
Preoperative euthyroidism is needed to minimize the risk of intraoperative and postoperative complications, such as thyroid storm by surgery. Antithyroid drugs or steroid hormones are commonly used in primary hyperthyroidism for euthyroidism. However, there is no definite consensus for the preoperative management of a TSH secreting pituitary adenoma for the restoration of euthyroidism. Antithyroid drugs are not used for long-term the management of a TSH secreting pituitary adenoma, as they may cause rapid growth and greater invasiveness of the tumor due to a feedback mechanism, but they can be used for short-term management before neurosurgery. We experienced one case of a TSH secreting pituitary adenoma, which showed rapid free thyroid hormone increase due to the short term administration of antithyroid drugs for only 10 days. A somatostatin analogue, octreotide at a dose of 0.1mg, twice a day, was then tried. About 4 weeks later, her serum TSH and free T4 had normalized, with a concomitant clinical improvement. She subsequently underwent an uncomplicated trans-sphenoidal resection of the pituitary adenoma. Antithyroid drugs can induce a rapid thyroid hormone increase, but can only be used for a short-term period, so they should be administered with caution or their use reconsidered
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A Case of Thyroid MALT Lymphoma without Autoimmune Thyroiditis.
Ok Nyu Kong, Sang Hyen Joo, Sun Hye Shin, Min Ah Na, Jun Hyeop An, Yang Ho Kang, Do Youn Park, Seok Man Son, In Ju Kim, Yong Ki Kim
J Korean Endocr Soc. 2005;20(3):268-272.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.268
  • 1,803 View
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  • 2 Crossref
AbstractAbstract PDF
A primary thyroid lymphoma is rare among all types of thyroid malignancy. Usually, a thyroid lymphoma is associated with underlying chronic autoimmune thyroiditis. Recently, we experienced a primary thyroid mucosa-associated lymphoid tissue(MALT) lymphoma, with an incidental micropapillary thyroid carcinoma, but lacking evidence of autoimmune thyroiditis. A female patient visited our hospital for further evaluation of a rapidly enlarging, painless thyroid mass which had been stable for 8 years. Lymphocytic thyroiditis or a lymphoma was suspected from fine needle aspiration performed at another hospital. The thyroid function test and other routine laboratory tests were normal. The histopathological findings after a total thyroidectomy revealed a MALT lymphoma with a micropapillary thyroid carcinoma. There was no evidence of chronic autoimmune thyroiditis. This is, to the best of our knowledge, the first case report of a MALT lymphoma arising from the thyroid gland without evidence of chronic autoimmune thyroiditis in Korea

Citations

Citations to this article as recorded by  
  • Primary Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid with the Serial Ultrasound Findings
    Eon Ju Jeon, Ho Sang Shon, Eui Dal Jung
    Case Reports in Endocrinology.2016; 2016: 1.     CrossRef
  • Autoimmune Thyroid Diseases
    Jong Ryeal Hahm
    Hanyang Medical Reviews.2012; 32(4): 219.     CrossRef
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A Case of Tracheal Adenoid Cystic Carcinoma Presenting with Diffuse Goiter.
Ho Cheol Kang, Seong Kyun Kim, Se Hoon Kang, Kyung Min Kim, Se In Hong, Dong Jin Chung, Min Young Chung, Joon Kyoo Lee, Sang Chul Lim, Jae Hyuk Lee
J Korean Endocr Soc. 2005;20(3):273-277.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.273
  • 1,687 View
  • 21 Download
AbstractAbstract PDF
A goiter is among the most common presenting symptoms of patients with thyroid diseases and is usually caused by intrinsic thyroid problems. While direct invasion of the trachea by aggressive thyroid tumors is a well-known phenomenon, the reverse situation, that is, a primary tracheal neoplasm invading by direct extension into the thyroid gland, presenting with a goiter is very rare. Here, a case of a tracheal adenoid cystic carcinoma(ACC), presenting with a diffuse goiter, is reported. A 47-year-old woman presented with slowly growing anterior neck swelling. A physical examination showed a diffuse firm goiter. The patient was euthyroiditic, and serum negative for thyroid autoantibodies. Thyroid ultrasonography and neck CT revealed a doughnut-shaped mass, encircling the trachea and displacing the thyroid anteriorly. Ultrasonography-guided fine needle aspiration(FNA) was compatible with an ACC, and a subsequent surgical resection confirmed the diagnosis. Although the occurrence of a tracheal ACC invading the thyroid is rare, this case highlights the need to be aware of unusual lesions arising in the region of the thyroid. This knowledge will help in making the correct cytological diagnosis when these lesions are sampled by FNA
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A Case of Primary Hyperparathyroidism Caused by Cystic Parathyroid Adenoma, Diagnosed during Intra-Operative PTH Monitoring.
Hye Jin Yoo, Nan Hee Kim, Soo Yeon Park, Dong Jin Kim, Sae Jeung Yang, Ju Ri Park, Hee Young Kim, Ji A Seo, Kye Won Lee, Sin Gon Kim, Kyung Mook Choi, Jae Bok Lee, Young Seok Lee, Sei Hyun Baik, Dong Seop Choi
J Korean Endocr Soc. 2005;20(3):278-282.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.278
  • 1,538 View
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AbstractAbstract PDF
Primary hyperparathyroidism is the most frequent cause of hypercalcemia, and its prevalence is increasing due to the routine examination of serum calcium levels. Primary hyperparathyroidims is most commonly caused by an adenoma or hyperplasia of the parathyroid gland. A cystic parathyroid adenoma is an extremely rare cause of primary hyperparathyroidism. In our case, a-79-year old female presented with lower back pain and constipation. Her serum calcium, phosphate and immunoreactive parathyroid homone levels were 15.6, 1.8mg/dL and 371.8pg/mL, respectively. Neck CT revealed a cystic mass and a contour bulging heterogeneous mass in the left inferior right thyroid gland, respectively. These mass lesions were removed, and the intra-operative parathyroid hormone levels monitored, to confirm the complete resection. After removing the left cystic mass to the inferior thyroid, the serum calcium and immunoreactive parathyroid hormone levels quickly returned to normal. We report a case of primary hyperparathyroidism, caused by a cystic parathyroid adenoma, with a brief review of the literature
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A Case of Pheochromocytoma Presented with Cardiogenic Shock.
Mi Young Do, Hee Man Kim, Young Guk Ko, Sung Kil Lim, Jae Hun Jung, Namsik Chung, Yeon A Kim, Shin Ae Kang, Jae Hoon Moon, Jin Hyung Lee, Sang Tae Choi
J Korean Endocr Soc. 2005;20(3):283-288.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.283
  • 1,709 View
  • 20 Download
  • 1 Crossref
AbstractAbstract PDF
A pheochromocytoma is a catecholamine secreting tumor, which is often overlooked when cardiovascular complications, such as acute heart failure, myocardial infarction, angina pectoris, arrhythmias, and dilated cardiomyopathy, presented as the initial clinical manifestations. Failure to identify a pheochromocytoma in these situations may be fatal. We report the case of 32-year-old female, who presented with cardiogenic shock. Echocardiography revealed severe global hypokinesia of the dilated left ventricle, with the exception of the apex. Computed tomography of the aorta showed a well-enhanced left adrenal mass, 3.5cm in diameter. A 24 hour urine collection study for catecholamines and a 131I-metaiodobenzylguanidine(MIBG) scan were suggestive of the diagnosis of a single adrenal pheochromocytoma. The patient stabilized after shock management, and recovered with intensive medical treatment. Follow-up echocardiography revealed normalized cardiac function and chamber dimensions. Thereafter, the adrenal mass was successfully removed using laparaoscopic surgery, without complications

Citations

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  • A Case of Pheochromocytoma Crisis with Acute Myocardial Infarction Induced by Glucocorticoids Administration
    Woo Sun Rou, Sang Kyung Jung, Sung Yun Lee, Yun Jeong Lee, Dong Jun Kim, Young Doo Kim, Hyung Yoon Kim, Sunhee Chang, Jung Hyun Noh
    Endocrinology and Metabolism.2010; 25(3): 240.     CrossRef
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A Case of Graves' Disease associated with Idiopathic Thrombocytopenic Purpura.
Wan Ho Kim, Eun Kyoung Choi, Se Hee Yoon, In Beom Jeong, Do Yeun Cho, Keun Yong Park
J Korean Endocr Soc. 2005;20(3):289-293.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.289
  • 1,697 View
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AbstractAbstract PDF
The association of Graves' disease and idiopathic thrombocytopenic purpura(ITP) is a rather rare, but well documented condition, and has also been reported a few times in Korea. At present, two main hypothetical mechanisms are used to explain the association of the two diseases; the presence of autoimmunity, which leads to both diseases, and activation of the reticuloendothelial system by thyroid hormone. A 33 year old female patient visited our hospital with mucosal bleeding and purpura over her entire body of 3 days duration. Her initial platelet count was 2x109/L, and the thyroid function tests showed a suppressed TSH level of 0.09 mU/L(0.4~3.1) and elevated levels of triiodothyronine and free thyroxine. The levels of anti-thyroglobulin Ab anti-TPO Ab, and anti-TSH receptor Ab were also elevated. The clinical, laboratory and bone marrow findings were compatible with Graves' disease associated with ITP. She was treated with methylprednisolone and propylthiouracil, after which her platelet count increased and thyroid function normalized. We report a case of Graves' disease associated with ITP, which was treated well by glucocorticoid and antithyroid medications
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A Case of Hashimoto's Thyroiditis with Transient T3-Thyrotoxicosis Induced by Hydatidiform Mole.
Ji Youn Yoo, Hong Ju Moon, Cheol Young Park, Seong Jin Lee, In Kyung Jeong, Eun Gyung Hong, Gi Weon Oh, Hyeon Kyu Kim, Doo Men Kim, Jae Myung Yoo, Sung Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Sung Woo Park, Soo Kee Min
J Korean Endocr Soc. 2005;20(3):294-298.   Published online June 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.3.294
  • 1,885 View
  • 19 Download
  • 1 Crossref
AbstractAbstract PDF
Human chorionic gonadotropin(HCG) is a member of the glycoproteins family synthesized by the placenta, which consists of 2 noncovalently joined subunits(alpha(alpha) and beta(beta)). The alpha- and beta-subunits have a structural homology with the alpha- and beta-subunits of TSH and LH. The thyrotropic action of HCG results from its structural similarity to TSH, so beta-HCG can bind to the TSH receptor in the thyroid gland. A high level of HCG accompanied by an increased thyroid hormone level, can be observed in gestational trophoblastic disease (GTD), such as a hydatidiform mole or a choriocarcinoma, but the clinical symptoms of hyperthyroidism are rarely observed. We experienced a case of Hashimoto's thyroiditis, where the patient was diagnosed with T3-thyrotoxicosis, which had initially been induced by excess beta-HCG due to an H-mole; after evacuation of the H-mole, the condition was diagnosed as hypothyroidism. It has been speculated that a patient with Hashimoto's thyroiditis could have hyperthyroidism, induced by beta-HCG, due to an H-mole

Citations

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  • Transient T3 toxicosis associated with Hashimoto’s disease
    Sarah Jaroudi, Meredith Gavin, Kathryn Boylan, Alan N. Peiris
    Baylor University Medical Center Proceedings.2019; 32(1): 80.     CrossRef
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