Endocrinology and Metabolism

Volume 23(4); August 2008

Review Articles

Novel Adipokines.: Kyung Mook Choi; J Korean Endocr Soc. 2008;23(4):219-222. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.219

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Abstract PDF: No abstract available.

Pharmacological Treatment of Obesity.: Soon Jib Yoo; J Korean Endocr Soc. 2008;23(4):223-233. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.223

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Abstract PDF

No abstract available.

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Anti-Obesity Effects of Raphanus sativus Water Extract on High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes
Seon Kyeong Park, Sang Yoon Choi, Yu Geon Lee
Journal of the Korean Society of Food Science and Nutrition.2024; 53(9): 904. CrossRef
Study on the Criteria for Priority-Setting and Application in Expanding Health Insurance Benefit of Preventive Medical Service: The Case of Obesity
Gyuwon Ra, Sunmi Lee
Korean Journal of Family Practice.2023; 13(2): 88. CrossRef
Effect of Complex Korean Medicine Treatment on Obese Patient: A Retrospective Study
Byung Jun Kim, Eun Jung Lee, Young Jin Kim, Won Hae Ku, Won Gu Lee, Ki Byoung Kim, Min Seok Oh
Journal of Korean Medicine for Obesity Research.2022; 22(1): 47. CrossRef
Effects of Cabbage-Apple Juice Fermented by Lactobacillus plantarum EM on Lipid Profile Improvement and Obesity Amelioration in Rats
Sihoon Park, Hee-Kyoung Son, Hae-Choon Chang, Jae-Joon Lee
Nutrients.2020; 12(4): 1135. CrossRef
Anti-oxidant and anti-adipocyte differentiation ofAster glehniandAster yomena
Ji Yeon Lee, Jeong-Yong Park, Hyung Don Kim, Seung Eun Lee, Jeong Hoon Lee, Yunji Lee, Kyung Hye Seo
Journal of Nutrition and Health.2019; 52(3): 250. CrossRef
Enhancement of Anti-Obesity Activities of Aronia melanocarpa Elliot Extracts from Low Temperature Ultrasonification Process
Nam Young Kim, Jeong Min Lee, Jae Yong Lee, Hyeon Yong Lee
Korean Journal of Medicinal Crop Science.2016; 24(4): 309. CrossRef
Weight loss effects of Bariatric Surgery after nutrition education in extremely obese patients*
Eun-Ha Jeong, Hong-Chan Lee, Jung-Eun Yim
Journal of Nutrition and Health.2015; 48(1): 30. CrossRef
Suppressive Effect of Acorn (Quercus acutissima Carr.) Extracts in 3T3-L1 Preadipocytes
Ji-Yeon Kim, Jin Lee, Chang-Won Lee, Ae-Jung Kim
The Korean Journal of Food And Nutrition.2015; 28(4): 650. CrossRef
Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women
Mi Joung Kim, Jung Hyun Hwang, Hyun Ji Ko, Hye Bock Na, Jung Hee Kim
Nutrition Research.2015; 35(5): 409. CrossRef
Weight loss effects of Bariatric Surgery after nutrition education in extremely obese patients*
Eun-Ha Jeong, Hong-Chan Lee, Jung-Eun Yim
Journal of Nutrition and Health.2015; 48(1): 30. CrossRef
Effect of Probiotics-Fermented Samjunghwan on Differentiation in 3T3-L1 Preadipocytes
Mi-Young Song, Shambhunath Bose, Ho-Jun Kim
Journal of the Korean Society of Food Science and Nutrition.2013; 42(1): 1. CrossRef
Effects of CJB Water Extract on Obesity-Related Factors in Hypothalamus of Rats Fed High-Fat Diet
Jeong-Soo Hwang, Jang-Mi Suk, Hye-Min Choi, In-Soon Shin, Su-Jung Hwang, Ji-Young Park, Sung-Ok Kim, Bu-Il Seo, Mi-Ryeo Kim
The Korea Journal of Herbology.2012; 27(5): 99. CrossRef
Effects of Weight Control Program on Dietary Habits and Blood Composition in Obese Middle-Aged Women
Hye-Kyung Kim, Mi-Jeong Kim
The Korean Journal of Nutrition.2010; 43(3): 273. CrossRef

Editorial

Type 2 Diabetes Mellitus and Arterial Stiffness.: Sung Hee Choi; J Korean Endocr Soc. 2008;23(4):234-237. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.234

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Abstract PDF: No abstract available.

Original Articles

Effects of Simvastatin on the Growth and Invasion of Anaplastic Thyroid Cancer Cells Lines.: Hyun Jeung Choi, Tae Yong Kim, Eui Young Kim, Won Gu Kim, Won Bae Kim, Young Kee Shong; J Korean Endocr Soc. 2008;23(4):238-244. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.238

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Abstract PDF

BACKGROUND
Anaplastic thyroid carcinoma has grave prognosis with most patient dying within 6 months of diagnosis. 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors have been reported to have an anticancer effect in experimental and clinical studies. In this study, we investigated the effect of HMG-CoA reductase inhibitors on cell growth, invasiveness, adherence and signal transduction to evaluate the possibility of simvastatin as an agent for treatment of thyroid cancer. METHODS: The viability of simvastatin treated 3 thyroid cancer cell lines (FRO, WRO, and ARO) were determined. We evaluated the cell migration, anchorage-independent growth and invasion ability in anaplastic thyroid cell line. The expression and phosphorylation of focal adhesion kinase (FAK) and extracellular signal-regurated kinase (ERK) were determined by immunoblot analysis. RESULTS: Three thyroid cancer cell lines showed concentration dependent decrease of viability after treatment with 100~200 mM of simvastatin. Anaplastic ARO cell line showed the most predominant decrease in viability. In ARO cell lines, cell migration was decreased by concentration dependent manner after treatment with simvastatin (concentration > or = 5 mM). Anchorage independent colony formation also decreased after simvastatin (> or = 10 mM). Finally, immunoblot analysis revealed that the phosphorylation status of FAK and ERK decreased in time dependent manner following treatment with 10 mM of simvastatin. CONCLUSION: The results of this study suggest that simvstatin exerts a favorable effect on the progression and metastasis of thyroid cancer. However, further studies are needed to elucidate the related mechanisms and signal transductions prior to its therapeutic application.

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The Effect of Atorvastatin and Simvastatin on NIS Expression of the TPC-1 Cell under the Therapeutic Blood Concentrations
Tae Kyoon Kim, Hye Sook Jung, Chang Shin Yoon, Jung Hae Ko, Hae Jung Jun, Min Jung Kwon, Sun Hee Lee, Mi Kyung Kim, Jeong Hyun Park
Endocrinology and Metabolism.2010; 25(3): 192. CrossRef

Change in Thyroid Autoantibodies According to the Clinical Course of Painless Thyroiditis Excluding Postpartum Thyroiditis.: Ihn Suk Lee, Young Suk Jo, Bon Jeong Ku, Minho Shong, Young Kun Kim, Heung kyu Ro; J Korean Endocr Soc. 2008;23(4):245-252. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.245

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Abstract PDF: BACKGROUND
Painless thyroiditis is characterized by painless, destructive inflammation of the thyroid gland. Although thyroid autoantibodies are frequently detected in patients suffering from this condition, the clinical significance of these antibodies is not well understood. Therefore, this study was conducted to investigate the relationship between thyroid function and thyroid autoantibodies in painless thyroiditis according to clinical course. METHODS: Patients proven to have painless thyroiditis were retrospectively included in this study. We analyzed their clinical features, thyroid function and titers of thyroid autoantibodies according to clinical course, which was divided into three phases; thyrotoxic, hypothyroid and recovery. RESULTS: Of the 21 patients included in this study, 2 were male and 19 were female. During the thyrotoxic phase, the mean free T4 concentration was 4.03 (2~6.8) ng/mL and the mean concentration of thyroid stimulating hormone (TSH) was 0.02 (0.01~0.07) U/mL. In addition, the titer of antithyroglobulin antibody and antithyroid peroxidase antibody was 298 (4.8~995) U/mL and 3318 (0.1~25280) U/mL, respectively during this phase. During the hypothyroid phase, the mean TSH was 16.3 (4.3-49.5) U/mL and was found to be positively correlated with the level of free T4 observed during the thyrotoxic phase (r = 0.523, P = 0.031). During the recovery phase, the titer of antithyroglobulin antibody was significantly reduced to 180 (38~487) U/mL when compared with the titer taken during the thyrotoxic phase (P = 0.016). Additionally, during the hypothyroid phase, patients found to have antithyroid peroxidase antibody had a higher titer of TSH than those that did not (23.9 (6.5~49.5) vs. 11.2 (5.3~18.2) U/mL, P = 0.004). CONCLUSION: The titer of free T4 and the presence of antithyroid peroxidase observed during the thyrotoxic phase were related to the titer of TSH during hypothyroid phase. Additionally, the titer of antithyroglobulin antibody was significantly reduced during the recovery phase.

Determinants of the Brachial-Ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes Mellitus.: Seong Woo Lee, Kyung Won Yun, Yun Sik Yu, Hong Kyu Lim, Yung Pil Bae, Byung Do Lee, Bo Hyun Kim, Chang Won Lee; J Korean Endocr Soc. 2008;23(4):253-259. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.253

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Abstract PDF

BACKGROUND
Pulse wave velocity (PWV) correlates with arterial distensibility and stiffness and is a useful method for evaluating the severity of systemic atherosclerosis in adults. Brachial-ankle PWV (baPWV) is affected by many different factors such as age, systolic blood pressure (SBP), sex, body mass index, waist to hip ratio, and HbA1c. We evaluated the determinants of baPWV in patients with type 2 diabetes mellitus. METHODS: The study included 803 type 2 diabetic patients over age 30 who had their ankle brachial pressure index (ABI) and baPWV measured at Busan St. Mary's Medical Center, Busan, Korea. Anthropometric parameters, blood pressure, pulse pressure, fasting plasma glucose, fasting insulin, HbA1c, lipid profile, high sensitivity C-reactive protein (hs-CRP), and microalbuminuria were checked concurrently. We also investigated tobacco and alcohol use by means of questionnaire. We then retrospectively analyzed the relationships between baPWV and various risk factors. RESULTS: Differences between men and women were measured using the independence sample probate. Pearson correlation analysis confirmed the factors affecting the baPWV as follows: SBP, diastolic blood pressure, pulse pressure, age, waist circumference, gender, and duration of diabetes mellitus were positively correlated, and height and weight were negatively correlated. On aged-adjusted partial correlation, HbA1c, SBP, diastolic blood pressure, and pulse pressure were correlated. By multiple linear regression analysis, SBP, age, HbA1c, and weight were independent predictors of baPWV. CONCLUSION: The baPWV is principally affected by SBP and age in patients with type 2 diabetes mellitus.

Citations

Citations to this article as recorded by

Factors Affecting Arterial Stiffness and Brachial-Ankle Pulse Wave Velocity in Patients With Type 2 Diabetes
Tomoki Furuya, Shinji Kitahama, Yuma Tamura, Susumu Ogawa, Yuki Nakatani, Takanori Yasu
Cureus.2024;[Epub] CrossRef
High Brachial Ankle Pulse Wave Velocity as a Marker for Predicting Coronary Artery Stenosis in Patients with Type 2 Diabetes
Bo Hyun Kim, Jae Sik Jang, Yong Seop Kwon, June Hyung Kim, In Joo Kim, Chang Won Lee
Endocrinology and Metabolism.2018; 33(1): 88. CrossRef
Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes
Byung Kil Ha, Bong Gun Kim, Dong Hyun Kim, Soon Il Lee, Soon Myung Jung, Ja Young Park, Chang Won Lee, Sang Soo Kim, Bo Hyun Kim, In Ju Kim
Diabetes & Metabolism Journal.2012; 36(6): 443. CrossRef
Relationships between Cardiac Autonomic Neuropathy and the Brachial-ankle Pulse Wave Velocity in Patients with Type 2 Diabetes
Young Pil Bae, Byeong Do Yi, Bong-Gun Kim, Jong-Hwa Park, Yong Seop Kwon, Ja Young Park, Chang Won Lee, Bo Hyun Kim, Jae-Sik Jang
Endocrinology and Metabolism.2011; 26(1): 44. CrossRef
Type 2 Diabetes Mellitus and Arterial Stiffness
Sung Hee Choi
Journal of Korean Endocrine Society.2008; 23(4): 234. CrossRef

Case Reports

A Case of Panhypopituitarism and Central Diabetes Insipidus Caused by Primary Central Nervous System Lymphoma.: Mi Sun Ahn, Soon Sun Kim, Tae Ho Kim, Seung Jin Han, Dae Jung Kim, Hugh Chul Kim, Se Hyuk Kim, Jae Ho Han, Ho Sung Kim, Yoon Sok Chung; J Korean Endocr Soc. 2008;23(4):260-265. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.260

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Abstract PDF: Primary central nervous system (CNS) lymphoma is an uncommon neoplasm. However, the incidence of primary CNS lymphoma has increased more than 10-fold over the past three decades, and continues to accelerate. Currently, primary CNS lymphoma represents 4 to 7 percent of all newly diagnosed primary CNS tumors. Primary CNS lymphoma may arise from different parts of the brain, with deep hemispheric periventricular white matter being the most common site of origin. The presenting symptoms in primary CNS lymphoma vary depending on the location of the mass. Involvement of the hypothalamic-pituitary axis may cause hypopituitarism, diabetes insipidus, headache, diplopia, and blurred vision.

A Case of Multiple Endocrine Neoplasia Type I with Atypical Clinical Course.: Yun Sun Choi, Youn Sun Bai, Bon Jeong Ku, Young Suk Jo, Young Kun Kim, Heung Kyu Ro, Minho Shong; J Korean Endocr Soc. 2008;23(4):266-271. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.266

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Abstract PDF

Multiple endocrine neoplasia type 1 (MEN 1) is characterized by the combined occurrence of primary hyperparathyroidism, enteropancreatic tumors and anterior pituitary adenoma. Yet carcinoid tumors, adrenal adenoma and lipoma might exist simultaneously. Thymic carcinoid tumors, which are recognized as one of the causes of death for patients with MEN 1, are uncommon and their natural history has barely been investigated.

Citations

Citations to this article as recorded by

A rare case of multiple endocrine neoplasia type 1 initially presenting as an asymptomatic, huge mediastinal mass: case report
Ji Eun Jun, You-Cheol Hwang, Kyu Jeong Ahn, Ho Yeon Chung, In-Kyung Jeong
BMC Endocrine Disorders.2021;[Epub] CrossRef
A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid
Suk Ki Park, Moon Won Lee, In Sub Han, Young Joo Park, Sung Yong Han, Joon Woo Park, Bong Eun Lee, Gwang Ha Kim, Sang Soo Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2019; 19(1): 65. CrossRef
Incidental metastatic mediastinal atypical carcinoid in a patient with parathyroid adenoma: a case report
Zareen Kiran, Asma Ahmed, Owais Rashid, Saira Fatima, Faizan Malik, Saulat Fatimi, Mubassher Ikram
Journal of Medical Case Reports.2017;[Epub] CrossRef
Multiple Endocrine Neoplasia Type 1 Presenting with an Invasive Giant Prolactinoma
Jinhoon Cha, Jin Seo Kim, Jung Suk Han, Yeon Won Park, Min Joo Kim, Yun Hyi Ku, Hong Il Kim
The Korean Journal of Medicine.2016; 91(3): 300. CrossRef
Genetic and Epigenetic Analysis in Korean Patients with Multiple Endocrine Neoplasia Type 1
Yoon Jung Chung, Sena Hwang, Jong Ju Jeong, Sun Yong Song, Se Hoon Kim, Yumie Rhee
Endocrinology and Metabolism.2014; 29(3): 270. CrossRef
A Case of Asymptomatic Multiple Endocrine Neoplasia Type 1 Detected Incidentally on Health Screening
Pyung-San Cho, Hoon Park, Guk-Haeng Lee, Myung-Chul Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2012; 55(6): 373. CrossRef

A Case of Carcinoma Showing Thymus-Like Differentiation (CASTLE) in the Thyroid.: Eun Hee Kim, Ji Yun Jeong, Eui Young Kim, Sang Ah Lee, Kyung Min Kim, Ji Hye Yim, Won Gu Kim, Tae Yong Kim, Sun A Kim, Gyungyup Gong, Young Kee Shong, Won Bae Kim; J Korean Endocr Soc. 2008;23(4):272-276. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.272

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Abstract PDF

Carcinoma Showing Thymus-Like Differentiation (CASTLE) is a very rare malignant neoplasm of the thyroid, and this resembles lymphoepithelioma or squamous cell carcinoma of the thymus. It originates from ectopic thymic tissue or remnants of the branchial pouches. We recently experienced a case of CASTLE in the thyroid gland of a 61-year-old woman. She presented with an asymptomatic mass in the right thyroid gland and she was diagnosed with 'poorly differentiated carcinoma' of the thyroid by fine needle aspiration cytology (FNAC). Total thyroidectomy was performed for both diagnostic and therapeutic purposes. Histologic examination of the resected tumor showed that the tumor was lobulated with expanding fibrous bands, and it was infiltrated by lymphocytes and plasma cells. The tumor cells had oval, large vesicular nuclei and prominent nucleoli, and the immunohistochemical staining was positive for CD5 and bcl-2, so the patient was diagnosed with thyroid CASTLE. We report here on a case of CASTLE in the thyroid gland treated by surgery and external neck radiation therapy.

Citations

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Intrathyroidal thymic carcinoma exhibiting neuroendocrine differentiation: Case report with cytomorphology, immunocytochemistry, and review of the literature focusing on cytology
Wen‐hao Ren, Kun Dong, Xiao‐zheng Huang, Yan‐li Zhu
Diagnostic Cytopathology.2019; 47(11): 1197. CrossRef
Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report
Sunhee Chang, Mee Joo, Hanseong Kim
Korean Journal of Pathology.2012; 46(3): 302. CrossRef

A Family Case of Complete Androgen Insensitivity Syndrome in Sisters due to a Novel Mutation in the Androgen Receptor Gene.: Jun Mo Sung, Hyung Young Yoon, Hyon J Kim, Mi Ran Kim, Tae Hi Lee, Hee Jae Joo, Won Il Park, Yoon Sok Chung; J Korean Endocr Soc. 2008;23(4):277-283. Published online August 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.4.277

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Abstract PDF: Androgen insensitivity syndrome (AIS) is a hereditary disorder that's characterized by the female phenotype in spite of the 46, XY karyotype, and this is caused by mutation of the androgen receptor gene. We experienced a case of the complete type of AIS. A 20-yr-old woman was evaluated for primary amenorrhea. The patient had external genitalia of the female phenotype, but she had no ovaries or uterus. The abdominal computed tomography scan revealed suspected testes in the pelvic cavity. The chromosome analysis was reported as 46, XY. We identified an androgen receptor gene novel mutation, including CAT deletion at the position 1925~1927 and AG deletion at the position 2129~2130 of exon 5, in both the proband and her sister. The patient underwent laparoscopic gonadectomy due to the possibility of malignant tumor developing in the testes. The subject is now on estrogen supplementation and she is under regular follow-up; she is in a good condition.

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