Endocrinology and Metabolism

How Cells Communicate in the Bone Remodelling Process.: Thomas J Martin, Natalie A Sims; J Korean Endocr Soc. 2010;25(1):1-8. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.1

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COMPARISON OF THE EFFECTS OF WALKING AND BENCH-STEP EXERCISE ON OSTEOCALCIN AND CTX-1 IN POST-MENOPAUSAL WOMEN WITH OSTEOPENIA
Ignatio Rika Haryono, Angela Tulaar, Herawati Sudoyo, Ambrosius Purba, Murdani Abdullah, Sri Widia Jusman, Andri M. T. Lubis, Ermita I. Ibrahim Ilyas
Journal of Musculoskeletal Research.2017; 20(02): 1750012. CrossRef
Non-Linear Pattern Formation in Bone Growth and Architecture
Phil Salmon
Frontiers in Endocrinology.2015;[Epub] CrossRef

Role of AMPK in the Regulation of Cellular Energy Metabolism.: Joohun Ha, Sooho Lee; J Korean Endocr Soc. 2010;25(1):9-17. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.9

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Effects of Pharmacoacupuncture for Obesity: A Systematic Review and Meta-Analysis
Seyun Kim, Mi-Yeon Song, Won-Seok Chung, Hyungsuk Kim, Woo-Chul Shin, Junhyuk Kang, Joonwon Seo, Sangwoo Seo, Seung Ho Yu, Jung-Hyun Lim, Su-Hwan Ji, Jae-Heung Cho
Journal of Korean Medicine for Obesity Research.2023; 23(2): 112. CrossRef
Integrative approach to uncover antioxidant properties of Bupleuri Radix and its active compounds: Multiscale interactome-level analysis with experimental validation
Seon Been Bak, Yu Rim Song, Su-Jin Bae, Won-Yung Lee, Young Woo Kim
Free Radical Biology and Medicine.2023; 199: 141. CrossRef
Antidiabetic Effect of Fermented Mesembryanthemum crystallinum L. in db/db Mice Involves Regulation of PI3K-Akt Pathway
Hye-Lin Kim, Yunu Jung, Hyo In Kim, Nak-Yun Sung, Min-Jee Kim, In-Jun Han, Geon Kim, Eun Yeong Nho, Sang-Yun Park, Yohan Han, Ji Hoon Jung, Dong-Sub Kim, Jinbong Park
Current Issues in Molecular Biology.2023; 45(8): 6415. CrossRef
Anti-Obesity Effects of Imyo-san on High Fat Diet Induced Obese Mice
Seok-Beom Kang, Woo-Seok Shon, Young-Jun Kim, Chang-Hoon Woo
Journal of Korean Medicine Rehabilitation.2022; 32(2): 19. CrossRef
Anti-Obesity Effects and the Regulation of Energy Metabolism in Skeletal Muscle Tissues of Allii Fistulosi Bulbus Extract in High Fat Diet-Induced Obesity Mice
Yoon Yong Choi, Hyeon Soo Lee, Su Yeon Baik, Sumin Lim, Hyo Won Jung, Seok Yong Kang, Yong-Ki Park
Journal of Korean Medicine for Obesity Research.2022; 22(2): 102. CrossRef
The Effects of Taeksa-tang on Blood Lipid Profile and Anti Oxidation
Yun-Jin Lee, Eun-Byeol Lee, Hyeon-Ji Kim, Doo-Hwa Yang, Young-Jun Kim, Hee-Duk An
Journal of Korean Medicine Rehabilitation.2021; 31(2): 1. CrossRef
Genome-wide identification and characterization of the AMPK genes and their distinct expression patterns in response to air exposure in the Manila clam (Ruditapes philippinarum)
Jingtian Wang, Lei Fang, Qidi Wu, Dongdong Li, Zhongming Huo, Xiwu Yan
Genes & Genomics.2020; 42(1): 1. CrossRef
The Effects of Cinnamomum cassia Blume, Aconitum carmichaeli Debx, and Pueraria lobata Benth on Glucose and Energy Metabolism in C2C12 Myotubes
Mi-Young Song
Journal of Korean Medicine for Obesity Research.2015; 15(2): 131. CrossRef
Effect of submerged culture of Ceriporia lacerata mycelium on GLUT4 protein in db/db mouse
Eun Ji Shin, Ji-Eun Kim, Ji-Hye Kim, Yong Man Park, Sung Kyoon Yoon, Byeong-Churl Jang, Sam-Pin Lee, Byoung-Cheon Kim
Korean Journal of Food Preservation.2015; 22(6): 893. CrossRef

Recent Developments of Anti-diabetic Agents Undergoing 2 and 3 Phase Clinical Trials.: Jung Guk Kim; J Korean Endocr Soc. 2010;25(1):18-21. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.18

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Intensive Glycemic Control and the Prevention of Cardiovascular Disease in Type 2 Diabetes Mellitus: A Review and Consensus.: J Korean Endocr Soc. 2010;25(1):22-24. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.22

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Effects of Korean diet control nutrition education on cardiovascular disease risk factors in patients who underwent cardiovascular disease surgery
Su-Jin Jung, Soo-Wan Chae
Journal of Nutrition and Health.2018; 51(3): 215. CrossRef

Comparison of the Efficacy of Octreotide Long-acting Repeatable and Lanreotide Autogel in Acromegalic Patients.: Jeong Kyung Park, Eun Jig Lee; J Korean Endocr Soc. 2010;25(1):25-27. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.25

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Medical Treatment with Somatostatin Analogues in Acromegaly: Position Statement
Sang Ouk Chin, Cheol Ryong Ku, Byung Joon Kim, Sung-Woon Kim, Kyeong Hye Park, Kee Ho Song, Seungjoon Oh, Hyun Koo Yoon, Eun Jig Lee, Jung Min Lee, Jung Soo Lim, Jung Hee Kim, Kwang Joon Kim, Heung Yong Jin, Dae Jung Kim, Kyung Ae Lee, Seong-Su Moon, Dong
The Korean Journal of Medicine.2019; 94(6): 485. CrossRef

Effects of alpha-lipoic Acid on Differentiation of Thyroid Cancer Cells.: Won Gu Kim, Doo Hee Han, Hyun Jeung Choi, Eui Young Kim, Tae Yong Kim, Young Kee Shong, Won Bae Kim; J Korean Endocr Soc. 2010;25(1):28-36. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.28

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Abstract PDF: BACKGROUND
Induction of re-differentiation is necessary for the proper treatment of patients with recurrent or metastatic differentiated thyroid cancer (DTC) because cancer cells show de-differentiation in about 30% of these patients. In this study, we evaluated the expression of thyroid specific genes after treatment with various agents to induce re-differentiation in the follicular thyroid cancer cell line FTC-133. METHODS: FTC-133 cells were treated with U0126, LY294002, trichostatin A, retinoic acid (RA), 5'-azacytidine and alpha-lipoic acid (ALA). We evaluated mRNA expression of thyroid specific genes, thyroglobulin (Tg), sodium iodine symporter (NIS), PAX-8 and TTF-1 by reverse transcriptase polymerase chain reaction (PCR). Quantified expression of Tg mRNA was also evaluated by real-time PCR. RESULTS: The expression of Tg mRNA increased after 48 h of treatment with 0.1 uM RA and the expression of Tg mRNA and TTF-1 mRNA increased after 48-72 h of treatment with ALA (10~100 uM). There was no change in thyroid specific gene expression by the other agents. Increased expression of Tg mRNA was confirmed by real-time PCR (1.3 times by 10 uM ALA and 3.6 times by 100 uM ALA). There was no basal NIS mRNA expression in FTC-133 cells and none of the tested agents induced expression of NIS mRNA. There was no change in phosphorylation of AMPK1-alpha after ALA treatment of FTC-133 cells. CONCLUSION: ALA increases mRNA expression of Tg and TTF-1 of FTC-133 thyroid cancer cells and these effects are not mediated by activation of AMP kinase. The finding that ALA could be a potential re-differentiation inducing agent in thyroid cancer cells is novel. Further studies are needed to elucidate the mechanism of induction of re-differentiation. Furthermore, the effect of ALA on NIS expression and on iodine uptake should be evaluated using diverse thyroid cancer cell lines.

Comparison of the Efficacy of Octreotide Long-acting Repeatable and Lanreotide Autogel in Acromegalic Patients.: Seul young Kim, Dohee Kim; J Korean Endocr Soc. 2010;25(1):37-45. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.37

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BACKGROUND
Somatostatin analogues have been used as the first-line medical therapy for active acromegaly that is not completely cured, or which recurs after surgery. The aim of this study was to compare the effects of octreotide long-acting repeatable (LAR) and lanreotide Autogel. Such a comparison has not been reported in Korea. METHODS: Twenty-seven patients who had previously undergone surgery for acromegaly from December 2003 to March 2005 were included. We retrospectively investigated eight patients who underwent operation only and 19 patients who additionally received medical treatment after surgery (octreotide LAR, n = 5; lanreotide Autogel, n = 5). Growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels were measured. RESULTS: The mean pre-operative and post-operative levels of GH were lower in patients who underwent surgery only than in those who received adjuvant therapy, but IGF-I levels were not significantly different. In the 19 patients receiving medical treatment after unsuccessful surgery, the mean baseline GH levels were 24.2 microgram/L for octreotide LAR and 22.8 microgram/L for lanreotide Autogel (P = 0.711), and the mean GH levels 36 months post-treatment were 4.1 microgram/L and 2.5 microgram/L, respectively (P = 0.794). GH < 2.5 microgram/L represented 30% of octreotide LAR patients and 33.3% of lanreotide Autogel patients (P = 0.91). Patients with normal IGF-I levels represented 54.5% and 66.7%, respectively (P = 0.71). CONCLUSION: No significant difference in therapeutic effect of octreotide LAR and lanreotide Autogel was evident in 19 Korean acromegalic patients who were not completely cured by surgery and radiation therapy.

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Medical Treatment with Somatostatin Analogues in Acromegaly: Position Statement
Sang Ouk Chin, Cheol Ryong Ku, Byung Joon Kim, Sung-Woon Kim, Kyeong Hye Park, Kee Ho Song, Seungjoon Oh, Hyun Koo Yoon, Eun Jig Lee, Jung Min Lee, Jung Soo Lim, Jung Hee Kim, Kwang Joon Kim, Heung Yong Jin, Dae Jung Kim, Kyung Ae Lee, Seong-Su Moon, Dong
Endocrinology and Metabolism.2019; 34(1): 53. CrossRef

A Case of Follicular Thyroid Carcinoma Associated with Hemiagenesis of Thyroid Gland.: Bu Kyung Kim, Hyun Joo Jung, Ye Na Kim, Young Sik Choi, Yo Han Park, Hee Kyoung Chang, Jeong Hoon Kim; J Korean Endocr Soc. 2010;25(1):46-49. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.46

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Abstract PDF

Thyroid hemiagenesis is a rare congenital anomaly, in which one thyroid lobe fails to develop. Thyroid hemiagenesis is associated with thyroid diseases such as Graves' disease, Hashimoto's thyroiditis, colloidal goiter and thyroid follicular and papillary cancer. A 53-year-old female patient was diagnosed with a thyroid nodule on health examination. A 99mTc pertechnetate thyroid scan showed absent uptake in the left lobe and cold nodule on the right lobe of thyroid gland. By ultrasonography, we found hemiagenesis in the left thyroid gland and an irregular shaped thyroid nodule on the right lobe of thyroid gland. We performed ultrasonography guided fine needle aspiration and cytologic analysis showed indeterminate nature. Thyroidectomy was performed and finally diagnosed follicular carcinoma of thyroid gland. The authors report this case with a literature review.

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A Case of Thyroid Hemiagenesis with Concurrent Papillary Thyroid Carcinoma
Ye-Mo Nam, June Sik Park, Kyung Jin Na, Dongbin Ahn
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2011; 54(8): 557. CrossRef

A Case of Primary Hyperparathyroidism with Rapid Regression of a Brown Tumor after Parathyroidectomy.: Ji Young Mok, Ha Yeon Kim, Hsing Chien Ter, Sang Ock Kim, Dong Kyun Kim, Ji Sun Han, So Young Park, Sa Rah Lee, Mi Kyoung Park, Duk Kyu Kim; J Korean Endocr Soc. 2010;25(1):50-55. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.50

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Abstract PDF: Primary hyperparathyroidism is mainly caused by parathyroid adenoma (85%) and is characterized by hypercalcemia, osteoporosis, renal stones, and gastrointestinal and neurological disorders. Because of improvements in blood analysis over the last two decades, primary hyperparathyroidism is typically diagnosed early and asymptomatically. A rare clinical manifestations of primary hyperparathyroidism, brown tumors (osteitis fibrosa cystica), are osteolytic lesions resulting from long-term hyperparathyroidism. Radiologically, it is difficult to distinguish a brown tumor from plasmacytoma, multiple myeloma, or bone metastasis. We report a case of a 44-year-old man with primary hyperparathyroidism that caused a large brown tumor (11 x 5 x 8 cm) that mimicked plasmacytoma or cancer metastasis on pelvic magnetic resonance imaging. After a bone biopsy report that was highly suggestive of a brown tumor, serum calcium and intact parathyroid hormone levels were determined. The lesion was ultimately diagnosed as a brown tumor and a parathyroidectomy was performed. After 1 year, the lesion has nearly regressed by follow up of the anteroposterior view of the pelvis and bone mineral density has improved. The present case highlights the importance of considering brown tumors in the evaluation of patients presenting with hypercalcemia and osteolytic lesions without definite primary neoplasm.

Acromegaly with Diabetes Insipidus after Pituitary Tumor Removal: Successful Pregnancy and Delivery.: Sei Hyun Kim, Joo Il Kim, Yae Min Park, In Sik Won, Kwen Chul Shin, Yunjeong Jo, Sihoon Lee, Yeun Sun Kim, Ki Young Lee, Ie Byung Park; J Korean Endocr Soc. 2010;25(1):56-60. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.56

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Abstract PDF: A 33-year-old woman visited our hospital because of oligomenorrhea. Acromegaly was diagnosed based on elevated insulin like growth factor-I (IGF-I) and paradoxical growth hormone (GH) rise in oral glucose tolerance test. Pituitary macroadenoma was detected on magnetic resonance imaging (MRI). The pituitary tumor was removed. Still, diabetes insipidus developed. We prescribed desmopressin and bromocriptine. Two months post-surgery, IGF-I was decreased and a combined pituitary function test was normal, except for the follicle stimulating hormone response. Residual tumor was detected on MRI. The bromocriptine dose was increased and treatment with the long-acting somatostatin analogue octreotide long acting release (LAR) was begun. After the fifth round of octreotide LAR, IGF-I was normalized. After the seventh round of octreotide LAR, the patient became pregnant. Bromocriptine and octreotide LAR were stopped, and desmopressin was continued. Successful delivery occurred at week 38 of pregnancy. The patient was discharged without any complications. Acromegaly is a disease caused by chronic GH hypersecretion, generally related to a somatotroph adenoma. Amenorrhea and menstrual irregularities are common in acromegaly. Pregnancy rarely occurs because chronic anovulation usually exists. When gonadotroph axis was preserved, the possibility of pregnancy in a woman of child-bearing age with acromegaly should be considered.

A Case of Coexistence of Parathyroid and Papillary Thyroid Carcinoma.: Yoon Shick Yom, Myung Jun Lee, Hyun Woo Lim, Jeong Ho Park, Sung Tae Kim, Yu Mi Lee, Dong Ju Yang, Youn Zoo Cho, Moon Il Park, Kang Woo Lee, Keun Young Park, Dong Mee Lim, Byung Joon Kim; J Korean Endocr Soc. 2010;25(1):61-67. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.61

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Abstract PDF: Primary hyperparathyroidism is usually caused by a parathyroid adenoma, occasionally by primary parathyroid hyperplasia and rarely by parathyroid carcinoma. Coincidental occurrence of thyroid carcinoma in parathyroid adenoma is not uncommon, but synchronous parathyroid and thyroid carcinoma is extremely rare. Here, we describe a case of synchronous parathyroid carcinoma and papillary thyroid carcinoma.

Autoimmune Thyroiditis during Antiviral Therapy with Peginterferon.: Jung Min Roh, Jeong Seon Yoo, Yoon Bum Lee, Hye Rim An, Hong Kyu Choi, Kyo Tae Jung, Jong Suk Park, Kwan Sik Lee, Kyung Rae Kim; J Korean Endocr Soc. 2010;25(1):68-71. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.68

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Abstract PDF: Combination treatment with pegylated interferon and ribavirin has been established as a standard therapy for chronic hepatitis C. Although interferon therapy is relatively safe, an important side effect is the induction of autoantibodies and autoimmune disease, especially autoimmune thyroid disease. Interferon associated autoimmune thyroid disease can consist of autoimmune hypothyroidism, Graves' disease, and destructive thyroiditis. Thyroid disease may lead to dose reduction or discontinuation of therapy.

Secondary Pituitary Hyperplasia Induced by Hashimoto's Thyroiditis Related Hypothyroidism: A Case Report.: Kwang Joon Kim, Hyun min Kim, Obin Kwon, Eun Young Park, Yong ho Lee, Jae Won Hong, Jin Wi, Eun Jig Lee; J Korean Endocr Soc. 2010;25(1):72-77. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.72

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Abstract PDF

Pituitary hyperplasia associated with untreated primary hypothyroidism in children is a rare condition. There are only a few reports on this condition in children, and especially when pituitary hyperplasia is accompanied with Hashimoto thyroiditis and growth arrest. Here, we describe an unusual association of pituitary hyperplasia with hypothyroidism and growth retardation, and this was all caused by Hashimoto thyroiditis. Hormonal testing showed a low thyroxine level and a high thyroid stimulating hormone level, elevated anti-thyroglobulin, low growth hormone levels and prepubertal levels of gonadotropins. A large intrasellar mass expanding beyond the sella turcica was detected on magnetic resonance imaging (MRI). Homogeneous contrast enhancement of mass highly suggested that it was a pituitary hyperplasia rather than a pituitary tumor. Therapy with L-thyroxine resulted in rapid improvement of the clinical signs, including renewed growth, normalization of the hormone levels and resolution of the pituitary hyperplasia on MRI within 90 days. In children, prolonged unrecognized primary hypothyroidism might be accompanied by growth deficiency and pubertal disharmony. Physicians must be aware of pituitary hyperplasia in these cases.

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Pituitary macroadenoma secondary to Hashimoto’s thyroiditis: inadvertent diagnosis in a pre-pubertal girl
Deepanjan Bhattacharya, Rakesh Kumar, Jaivinder Yadav
Tropical Doctor.2020; 50(3): 240. CrossRef
Pituitary Hyperplasia Secondary to Hypothyroidism Caused by Hashimoto's Thyroiditis in a Female Adolescent
Jeoung Suk Kim, Min Sun Kim, Sun Jun Kim, Gyung Ho Chung, Pyoung Han Hwang, Dae-Yeol Lee
Journal of Korean Society of Pediatric Endocrinology.2011; 16(3): 185. CrossRef

A Case of Complete Agenesis of the Dorsal Pancreas in a Patient with Newly Diagnosed Diabetes Mellitus.: Dong Pil Kim, Kang Seo Park, Dong Sun Kim, Bong Suk Ko, Ji Hae Lee, Jae Hyuk Lee, Jong Ho Shin, Byung Jun Kim, Hyun Jin Kim; J Korean Endocr Soc. 2010;25(1):78-83. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.78

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Abstract PDF: Agenesis of the dorsal pancreas is a rare congenital anomaly caused by underdevelopment or agenesis of the dorsal pancreatic bud that forms the upper head, neck, body and tail of the pancreas. We report a case of agenesis of the dorsal pancreas, which was found under examination of diabetes mellitus (DM). A 16-year-old girl was transferred to our hospital because of a positive urine glucose reading during a school-conducted examination. Abdominal computed tomography and magnetic resonance cholangiopancreatography revealed the deficit of the pancreatic body and tail. Diabetes-associated autoimmune antibodies were negative in a blood test. Decreased beta-cell function was demonstrated by oral glucose tolerance and glucagon stimulation tests. Although the notion that agenesis of the dorsal pancreas leads to decreased endocrine or exocrine function is controversial, the results of this study suggest that we should consider these causes of diabetes mellitus. When treating a young patient with diabetes mellitus, we should consider causes of diabetes mellitus such as congenital anomaly or maturity onset diabetes, in addition to type 1 and type 2 diabetes mellitus.

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