Pituitary tumors represent the most common intracranial neoplasms accompanying serious morbidity through mass effects and inappropriate secretion of pituitary hormones. Understanding the etiology of pituitary tumorigenesis will facilitate the development of satisfactory treatment for pituitary adenomas. Although the pathogenesis of pituitary adenomas is largely unknown, considerable evidence indicates that the pituitary tumorigenesis is a complex process involving multiple factors, including genetic and epigenetic changes. This review summarized the recent progress in the study of pituitary tumorigenesis, focusing on the role of tumor suppressor genes, oncogenes and microRNAs.

Citations

Citations to this article as recorded by  

• Plurihormonal Pituitary Neuroendocrine Tumors: Clinical Relevance of Immunohistochemical Analysis
  Roxana-Ioana Dumitriu-Stan, Iulia-Florentina Burcea, Ramona Dobre, Valeria Nicoleta Nastase, Raluca Amalia Ceausu, Marius Raica, Catalina Poiana
  Diagnostics.2024; 14(2): 170.     CrossRef
• Pituitary Adenoma: SSTR2 rs2236750, SSTR5 rs34037914, and AIP rs267606574 Genetic Variants, Serum Levels, and Ki-67 Labeling Index Associations
  Greta Gedvilaite-Vaicechauskiene, Loresa Kriauciuniene, Arimantas Tamasauskas, Vita Rovite, Ilona Mandrika, Sheng-Nan Wu, Chin-Wei Huang, Lina Poskiene, Rasa Liutkeviciene
  Medicina.2024; 60(8): 1252.     CrossRef
• Single-Cell RNA Sequencing and Its Applications in Pituitary Research
  Shuangjian Yang, Congcong Deng, Changqin Pu, Xuexue Bai, Chenxin Tian, Mengqi Chang, Ming Feng
  Neuroendocrinology.2024; 114(10): 875.     CrossRef
• The expression of VDACs and Bcl2 family genes in pituitary adenomas: clinical correlations and postsurgical outcomes
  AN Facundo, M Magalhães, GC Nascimento, RS Azulay, RM Santos, LA Freitas, AGPAC Nascimento, VP Rodrigues, WC Santos, AMGS Beckman, JMF Abreu, RP Silva, EL Carneiro, CP Oliveira Neto, RM Gil da Costa, R Corcoy, E Mato, MS Faria
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Signal Transducer and Activator of Transcription 4 (STAT4) Association with Pituitary Adenoma
  Greta Gedvilaite-Vaicechauskiene, Loresa Kriauciuniene, Rasa Liutkeviciene
  Medicina.2024; 60(11): 1871.     CrossRef
• LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p
  Tuo Wang, Ping Mao, Yan Zhang, Bo Cui, Mao-De Wang, Ya Li, Ke Gao
  Anti-Cancer Drugs.2022; 33(10): 1058.     CrossRef
• Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor Cells
  Jun Y. Oh, Robert C. Osorio, Jangham Jung, Luis Carrete, Nikita Choudhary, Meeki Lad, Atul Saha, Manish K. Aghi
  Cancers.2022; 15(1): 110.     CrossRef
• EMT-Related Markers in Serum Exosomes are Potential Diagnostic Biomarkers for Invasive Pituitary Adenomas
  Kelin Chen, Guoge Li, Xixiong Kang, Pinan Liu, Lingye Qian, Yijun Shi, Rasha Alsamani Osman, Zhijun Yang, Guojun Zhang
  Neuropsychiatric Disease and Treatment.2021; Volume 17: 3769.     CrossRef
• The Role of Long Noncoding RNAs in the Biology of Pituitary Adenomas
  Ozal Beylerli, Ilgiz Gareev, Valentin Pavlov, Xin Chen, Shiguang Zhao
  World Neurosurgery.2020; 137: 252.     CrossRef
• Sellar Tumors
  Katherine E. Schwetye, Sonika M. Dahiya
  Surgical Pathology Clinics.2020; 13(2): 305.     CrossRef
• Genomic and molecular characterization of pituitary adenoma pathogenesis: review and translational opportunities
  Mazin Elsarrag, Parantap D. Patel, Ajay Chatrath, Davis Taylor, John A. Jane
  Neurosurgical Focus.2020; 48(6): E11.     CrossRef
• Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets
  Jie Feng, Hua Gao, Qi Zhang, Yang Zhou, Chuzhong Li, Sida Zhao, Lichuan Hong, Jinjin Yang, Shuyu Hao, Wan Hong, Zhengping Zhuang, Guowang Xu, Yazhuo Zhang
  Journal of Translational Medicine.2019;[Epub]     CrossRef
• Quantitative Analysis of Proteome in Non-functional Pituitary Adenomas: Clinical Relevance and Potential Benefits for the Patients
  Tingting Cheng, Ya Wang, Miaolong Lu, Xiaohan Zhan, Tian Zhou, Biao Li, Xianquan Zhan
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1
  Qiu Du, Bin Hu, Yajuan Feng, Zongming Wang, Xin Wang, Dimin Zhu, Yonghong Zhu, Xiaobing Jiang, Haijun Wang
  The Journal of Clinical Endocrinology & Metabolism.2019; 104(6): 2419.     CrossRef
• Differential Expression of HMGA1 and HMGA2 in pituitary neuroendocrine tumors
  Sérgio Portovedo, Nadja Gaido, Bruno de Almeida Nunes, Ana Giselia Nascimento, Allysson Rocha, Marcelo Magalhães, Gilvan Cortes Nascimento, Denise Pires de Carvalho, Paula Soares, Christina Takiya, Manuel dos Santos Faria, Leandro Miranda-Alves
  Molecular and Cellular Endocrinology.2019; 490: 80.     CrossRef
• Double Pituitary Adenomas with Synchronous Somatotroph and Corticotroph Clinical Presentation of Acromegaly and Cushing's Disease
  Naomi Collazo-Gutiérrez, Orlando de Jesús, Maria Villamil-Jarauta, Milliette Alvarado, Loida González, Margarita Ramírez, Victor J. Carlo-Chevere
  World Neurosurgery.2019; 132: 161.     CrossRef
• Association of ApoE haplotype with clinical evidence of pituitary adenoma
  Agne Sidaraite, Alvita Vilkeviciute, Brigita Glebauskiene, Loresa Kriauciuniene, Dalia Zaliuniene, Rasa Liutkeviciene
  Gene.2019; 706: 154.     CrossRef
• Next-generation sequencing of microRNAs reveals a unique expression pattern in different types of pituitary adenomas
  Zongze He, Longyi Chen, Xiao Hu, Jian Tang, Linfu He, Junting Hu, Fan Fei, Qi Wang
  Endocrine Journal.2019; 66(8): 709.     CrossRef
• Growth hormone and prolactin-staining tumors causing acromegaly: a retrospective review of clinical presentations and surgical outcomes
  Jonathan Rick, Arman Jahangiri, Patrick M. Flanigan, Ankush Chandra, Sandeep Kunwar, Lewis Blevins, Manish K. Aghi
  Journal of Neurosurgery.2019; 131(1): 147.     CrossRef
• Study of major genetic factors involved in pituitary tumorigenesis and their impact on clinical and biological characteristics of sporadic somatotropinomas and non-functioning pituitary adenomas
  R.K. Foltran, P.V.G.H. Amorim, F.H. Duarte, I.P.P. Grande, A.C.T.B. Freire, F.P. Frassetto, J.B. Dettoni, V.A. Alves, I. Castro, E.B. Trarbach, M.D. Bronstein, R.S. Jallad
  Brazilian Journal of Medical and Biological Research.2018;[Epub]     CrossRef
• Detection of circulating tumor cells in patients with pituitary tumors
  Gao Hua, He Yanjiao, Liu Qian, Wang Jichao, Zhang Yazhuo
  BMC Cancer.2018;[Epub]     CrossRef
• Plurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Review
  Elena Roca, Pier Paolo Mattogno, Teresa Porcelli, Luigi Poliani, Francesco Belotti, Alberto Schreiber, Filippo Maffezzoni, Marco Maria Fontanella, Francesco Doglietto
  World Neurosurgery.2018; 114: e158.     CrossRef
• The role of galectin-3 in the tumorigenesis and progression of pituitary tumors
  Bo Diao, Ying Liu, Guo‑Zheng Xu, Yi Zhang, Jun Xie, Jie Gong
  Oncology Letters.2018;[Epub]     CrossRef
• Programmed cell senescence: role of IL-6 in the pituitary
  Melanie Sapochnik, Mariana Fuertes, Eduardo Arzt
  Journal of Molecular Endocrinology.2017; 58(4): R241.     CrossRef
• Selective molecular biomarkers to predict biologic behavior in pituitary tumors
  Aydin Sav, Fabio Rotondo, Luis V. Syro, Meric A. Altinoz, Kalman Kovacs
  Expert Review of Endocrinology & Metabolism.2017; 12(3): 177.     CrossRef
• MicroRNA-200b inhibits pituitary tumor cell proliferation and invasion by targeting PKCα
  Yuanchuan Wang, Xiaohong Yin, Long Zhao, Shun Li, Jie Duan, Renzhao Kuang, Junwei Duan
  Experimental and Therapeutic Medicine.2017; 14(2): 1706.     CrossRef
• Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke’s cell morphology
  Filip Garbicz, Dawid Mehlich, Beata Rak, Emir Sajjad, Maria Maksymowicz, Wiktor Paskal, Grzegorz Zieliński, Paweł K. Włodarski
  Pituitary.2017; 20(4): 450.     CrossRef
• Bromocriptine Induces Autophagy-Dependent Cell Death in Pituitary Adenomas
  Xin Geng, Lixin Ma, Zefu Li, Zhenzhu Li, Jianmin Li, Meng Li, Qingbo Wang, Zheng Chen, Qikai Sun
  World Neurosurgery.2017; 100: 407.     CrossRef
• Biomarkers of pituitary carcinomas
  Aydin Sav, Fabio Rotondo, Luis V. Syro, Antonio Di Ieva, Michael D. Cusimano, Kalman Kovacs
  Expert Review of Endocrinology & Metabolism.2016; 11(3): 253.     CrossRef
• MicroRNAs in the pituitary
  Erica Gentilin, Ettore degli Uberti, Maria Chiara Zatelli
  Best Practice & Research Clinical Endocrinology & Metabolism.2016; 30(5): 629.     CrossRef
• Molecular markers in pituitary tumors
  Asha M. Robertson, Anthony P. Heaney
  Current Opinion in Endocrinology, Diabetes & Obesity.2016; 23(4): 324.     CrossRef
• MicroRNA-106b promotes pituitary tumor cell proliferation and invasion through PI3K/AKT signaling pathway by targeting PTEN
  Kai Zhou, Tingrong Zhang, YanDong Fan, Serick, Guojia Du, Pengfei Wu, Dangmurenjiafu Geng
  Tumor Biology.2016; 37(10): 13469.     CrossRef
• Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature
  JIUJUN PU, ZHIMING WANG, HUI ZHOU, AILING ZHONG, KAI JIN, LUNLIANG RUAN, GANG YANG
  Oncology Letters.2016; 12(1): 585.     CrossRef
• Progress in Endocrine Neoplasia
  Samuel A. Wells
  Clinical Cancer Research.2016; 22(20): 4981.     CrossRef
• Pituitary adenomas: historical perspective, surgical management and future directions
  Debebe Theodros, Mira Patel, Jacob Ruzevick, Michael Lim, Chetan Bettegowda
  CNS Oncology.2015; 4(6): 411.     CrossRef
• Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells
  Mark O. Kitchen, Kiren Yacqub-Usman, Richard D. Emes, Alan Richardson, Richard N. Clayton, William E. Farrell
  Pituitary.2015; 18(5): 674.     CrossRef
• Pituitary Adenoma and the Chemokine Network: A Systemic View
  Fabio Grizzi, Elena Monica Borroni, Alessandro Vacchini, Dorina Qehajaj, Manuela Liguori, Sanja Stifter, Maurizio Chiriva-Internati, Antonio Di Ieva
  Frontiers in Endocrinology.2015;[Epub]     CrossRef
• MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5
  Wang Renjie, Liang Haiqian
  Cancer Letters.2015; 356(2): 568.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Epigenetics of pituitary tumours
  William E. Farrell
  Current Opinion in Endocrinology, Diabetes & Obesity.2014; 21(4): 299.     CrossRef
• The Role of Genetic and Epigenetic Changes in Pituitary Tumorigenesis
  Hidenori FUKUOKA, Yutaka TAKAHASHI
  Neurologia medico-chirurgica.2014; 54(12): 943.     CrossRef

The last decade has seen an exponential increase in our understanding of osteocytes function and biology. These cells, once considered inert by-standers trapped into the mineralized bone, has now risen to be key regulators of skeletal metabolism, mineral homeostasis, and hematopoiesis. As tools and techniques to study osteocytes improved and expanded, it has become evident that there is more to these cells than initially thought. Osteocytes are now recognized not only as the key responders to mechanical forces but also as orchestrators of bone remodeling and mineral homeostasis. These cells are the primary source of several important proteins, such as sclerostin and fibroblast growth factor 23, that are currently target as novel therapies for bone loss (as the case for antisclerostin antibodies) or phosphate disorders. Better understanding of the intricate cellular and molecular mechanisms that govern osteocyte biology will open new avenue of research and ultimately indentify novel therapeutics to treat bone and mineral disorders. This review summarizes novel findings and discusses future avenues of research.

Citations

Citations to this article as recorded by  

• Study on the influence of scaffold morphology and structure on osteogenic performance
  Jingyu Zhou, Shilang Xiong, Min Liu, Hao Yang, Peng Wei, Feng Yi, Min Ouyang, Hanrui Xi, Zhisheng Long, Yayun Liu, Jingtang Li, Linghua Ding, Long Xiong
  Frontiers in Bioengineering and Biotechnology.2023;[Epub]     CrossRef
• New Insights Into Monogenic Causes of Osteoporosis
  Riikka E. Mäkitie, Alice Costantini, Anders Kämpe, Jessica J. Alm, Outi Mäkitie
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes
  Christopher Dedic, Tin Shing Hung, Alan M. Shipley, Akira Maeda, Thomas Gardella, Andrew L. Miller, Paola Divieti Pajevic, Joseph G. Kunkel, Alessandro Rubinacci
  Bone.2018; 116: 135.     CrossRef
• Ex vivo replication of phenotypic functions of osteocytes through biomimetic 3D bone tissue construction
  Qiaoling Sun, Saba Choudhary, Ciaran Mannion, Yair Kissin, Jenny Zilberberg, Woo Y. Lee
  Bone.2018; 106: 148.     CrossRef
• Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS
  Natalia Campos‐Obando, W Nadia H Koek, Elizabeth R Hooker, Bram CJ van der Eerden, Huibert A Pols, Albert Hofman, Johannes PTM van Leeuwen, Andre G Uitterlinden, Carrie M Nielson, M. Carola Zillikens
  Journal of Bone and Mineral Research.2017; 32(6): 1182.     CrossRef
• Intermittent PTH treatment can delay the transformation of mature osteoblasts into lining cells on the periosteal surfaces
  Mi-Gyeong Jang, Ji Yeon Lee, Jae-Yeon Yang, Hyojung Park, Jung Hee Kim, Jung-Eun Kim, Chan Soo Shin, Seong Yeon Kim, Sang Wan Kim
  Journal of Bone and Mineral Metabolism.2016; 34(5): 532.     CrossRef
• The osteoclasts attach to the bone surface where the extracellular calcium concentration decreases
  Bilu Xiang, Yang Liu, Lu Xie, Qian Zhao, Ling Zhang, Xueqi Gan, Haiyang Yu
  Cell Biochemistry and Biophysics.2016; 74(4): 553.     CrossRef
• The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density
  Christopher P Recknor, Robert R Recker, Charles T Benson, Deborah A Robins, Alan Y Chiang, Jahangir Alam, Leijun Hu, Toshio Matsumoto, Hideaki Sowa, John H Sloan, Robert J Konrad, Bruce H Mitlak, Adrien A Sipos
  Journal of Bone and Mineral Research.2015; 30(9): 1717.     CrossRef
• Promoting effect of 1,25(OH) 2 vitamin D 3 in osteogenic differentiation from induced pluripotent stem cells to osteocyte-like cells
  Hiroshi Kato, Hiromi Ochiai-Shino, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma
  Open Biology.2015; 5(2): 140201.     CrossRef
• From mechanical stimulus to bone formation: A review
  Natacha Rosa, Ricardo Simoes, Fernão D. Magalhães, Antonio Torres Marques
  Medical Engineering & Physics.2015; 37(8): 719.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef

Glucagon-like peptide 1 (GLP-1) is secreted from enteroendocrine L-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion. It also slows gastric emptying, which contributes to decreased postprandial glycemic excursions. In the 1990s, chronic subcutaneous infusion of GLP-1 was found to lower blood glucose levels in patients with type 2 diabetes. However, GLP-1's very short half-life, arising from cleavage by the enzyme dipeptidyl peptidase 4 (DPP-4) and glomerular filtration by the kidneys, presented challenges for clinical use. Hence, DPP-4 inhibitors were developed, as well as several GLP-1 analogs engineered to circumvent DPP-4-mediated breakdown and/or rapid renal elimination. Three categories of GLP-1 analogs, are being developed and/or are in clinical use: short-acting, long-acting, and prolonged-acting GLP-1 analogs. Each class has different plasma half-lives, molecular size, and homology to native GLP-1, and consequently different characteristic effects on glucose metabolism. In this article, we review current clinical data derived from each class of GLP-1 analogs, and consider the clinical effects reported for each category in recent head to head comparison studies. Given the relatively brief clinical history of these compounds, we also highlight several important efficacy and safety issues which will require further investigation.

Citations

Citations to this article as recorded by  

• Poly(l-threonine-co-l-threonine Succinate) Thermogels for Sustained Release of Lixisenatide
  Jin Kyung Park, Zhengyu Piao, Hyun Jung Lee, Byeongmoon Jeong
  Biomacromolecules.2024; 25(8): 4946.     CrossRef
• The efficacy and safety of combined GLP-1RA and basal insulin therapy among inadequately controlled T2D with premixed insulin therapy
  Jhih-Syuan Liu, Sheng-Chiang Su, Feng-Chih Kuo, Peng-Fei Li, Chia-Luen Huang, Li-Ju Ho, Kuan-Chan Chen, Yi-Chen Liu, Chih-Ping Lin, An-Che Cheng, Chien-Hsing Lee, Fu-Huang Lin, Yi-Jen Hung, Hsin-Ya Liu, Chieh-Hua Lu, Chang-Hsun Hsieh
  Medicine.2023; 102(10): e33167.     CrossRef
• Pharmacogenetics of Glucagon-like-peptide-1 receptor in diabetes management
  Mariya Kalinkova, Tanya Kadiyska, Teodora Handjieva-Darlenska
  Pharmacia.2023; 70(2): 383.     CrossRef
• Anti-inflammatory potential of liraglutide, a glucagon-like peptide-1 receptor agonist, in rats with peripheral acute inflammation
  Irem Mert, Ayhan Cetinkaya, Mujgan Gurler, Canan Akünal Turel, Humeyra Celik, Ibrahim Ethem Torun, Idris Turel
  Inflammopharmacology.2022; 30(3): 1093.     CrossRef
• Exenatide improves hepatocyte insulin resistance induced by different regional adipose tissue
  Chuanmin Bai, Yujun Wang, Zhi Niu, Yaxin Guan, Jingshan Huang, Xin Nian, Fan Zuo, Juan Zhao, Tsutomu Kazumi, Bin Wu
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists
  Hun Jee Choe, Young Min Cho
  Endocrinology and Metabolism.2021; 36(1): 22.     CrossRef
• Glucagon-like Peptide-1 Improves Fatty Liver and Enhances Thermogenesis in Brown Adipose Tissue via Inhibiting BMP4-Related Signaling Pathway in High-Fat-Diet-Induced Obese Mice
  Xingchun Wang, Bingwei Ma, Jiaqi Chen, Hui You, Chunjun Sheng, Peng Yang, Shen Qu, Vito Angelo Giagulli
  International Journal of Endocrinology.2021; 2021: 1.     CrossRef
• Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin
  Zeinab A. Saad, Dina M. Khodeer, Sawsan A. Zaitone, Amal A.M. Ahmed, Yasser M. Moustafa
  Life Sciences.2020; 253: 117725.     CrossRef
• Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease
  Shan Li, Xiaoman Wang, Jielei Zhang, Jingyi Li, Xiaogang Liu, Yuanyuan Ma, Chao Han, Lixia Zhang, Lili Zheng
  Brazilian Journal of Medical and Biological Research.2018;[Epub]     CrossRef
• Efficacy and safety of combination therapy with an α‐glucosidase inhibitor and a dipeptidyl peptidase‐4 inhibitor in patients with type 2 diabetes mellitus: A systematic review with meta‐analysis
  Se Hee Min, Jeong‐Hwa Yoon, Seokyung Hahn, Young Min Cho
  Journal of Diabetes Investigation.2018; 9(4): 893.     CrossRef
• Glucagon-like peptide-1 affects human umbilical vein endothelial cells in high glucose by the PI3K/Akt/eNOS signaling pathway
  Jie Wu, Pingfan Guo, Tianmin He, Fanggang Cai
  Turkish Journal of Biochemistry.2018; 43(2): 119.     CrossRef
• What next after basal insulin? Treatment intensification with lixisenatide in Asian patients with type 2 diabetes mellitus
  Wing B. Chan, Andrea Luk, Wing S. Chow, Vincent T.F. Yeung
  Journal of Diabetes.2017; 9(6): 562.     CrossRef
• Treatment potential of the GLP-1 receptor agonists in type 2 diabetes mellitus: a review
  L. Østergaard, Christian S. Frandsen, S. Madsbad
  Expert Review of Clinical Pharmacology.2016; 9(2): 241.     CrossRef
• Efficacy and safety of dulaglutide in the treatment of type 2 diabetes: a comprehensive review of the dulaglutide clinical data focusing on the AWARD phase 3 clinical trial program
  Johan Jendle, George Grunberger, Thomas Blevins, Francesco Giorgino, Ryan T. Hietpas, Fady T. Botros
  Diabetes/Metabolism Research and Reviews.2016; 32(8): 776.     CrossRef
• Glucagon‐like peptide‐1(GLP‐1) receptor agonists: potential to reduce fracture risk in diabetic patients?
  Guojing Luo, Hong Liu, Hongyun Lu
  British Journal of Clinical Pharmacology.2016; 81(1): 78.     CrossRef
• Impact of postprandial glucose control on diabetes-related complications: How is the evidence evolving?
  Sten Madsbad
  Journal of Diabetes and its Complications.2016; 30(2): 374.     CrossRef
• Risk assessment and management of post-transplant diabetes mellitus
  Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
  Metabolism.2016; 65(10): 1559.     CrossRef
• Recent advances in oral delivery of peptide hormones
  Pegah Varamini, Istvan Toth
  Expert Opinion on Drug Delivery.2016; 13(4): 507.     CrossRef
• Exendin-4 Inhibits Hepatic Lipogenesis by Increasing β-Catenin Signaling
  Mi Hae Seo, Jinmi Lee, Seok-Woo Hong, Eun-Jung Rhee, Se Eun Park, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won-Young Lee, Catherine Mounier
  PLOS ONE.2016; 11(12): e0166913.     CrossRef
• Review of head‐to‐head comparisons of glucagon‐like peptide‐1 receptor agonists
  Sten Madsbad
  Diabetes, Obesity and Metabolism.2016; 18(4): 317.     CrossRef
• Does Bosentan Protect Diabetic Brain Alterations in Rats? The Role of Endothelin‐1 in the Diabetic Brain
  Recep Demir, Elif Cadirci, Erol Akpinar, Yasemin Cayir, Hasan Tarik Atmaca, Harun Un, Celalettin Semih Kunak, Muhammed Yayla, Zafer Bayraktutan, Ilknur Demir
  Basic & Clinical Pharmacology & Toxicology.2015; 116(3): 236.     CrossRef
• Efficacy and tolerability of albiglutide versus placebo or pioglitazone over 1 year in people with type 2 diabetes currently taking metformin and glimepiride: HARMONY 5
  P. D. Home, P. Shamanna, M. Stewart, F. Yang, M. Miller, C. Perry, M. C. Carr
  Diabetes, Obesity and Metabolism.2015; 17(2): 179.     CrossRef
• Differential effects of prandial and non-prandial GLP-1 receptor agonists in type 2 diabetes therapy
  Jaime A. Davidson
  Postgraduate Medicine.2015; 127(8): 827.     CrossRef
• GLP‐1 receptor agonists: effects on the progression of non‐alcoholic fatty liver disease
  Jia Liu, Guang Wang, Yumei Jia, Yuan Xu
  Diabetes/Metabolism Research and Reviews.2015; 31(4): 329.     CrossRef
• Efficacy and safety of teneligliptin, a dipeptidyl peptidase‐4 inhibitor, combined with metformin in Korean patients with type 2 diabetes mellitus: a 16‐week, randomized, double‐blind, placebo‐controlled phase III trial
  M. K. Kim, E.‐J. Rhee, K. A. Han, A. C. Woo, M.‐K. Lee, B. J. Ku, C. H. Chung, K.‐A. Kim, H. W. Lee, I. B. Park, J. Y. Park, H. C. Chul Jang, K. S. Park, W. I. Jang, B. Y. Cha
  Diabetes, Obesity and Metabolism.2015; 17(3): 309.     CrossRef
• Incretin physiology and pathophysiology from an Asian perspective
  Young Min Cho
  Journal of Diabetes Investigation.2015; 6(5): 495.     CrossRef
• Response: Economic Impact of Combining Metformin with Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients with Renal Impairment in Spanish Patients (Diabetes Metab J2015;39:74-81)
  Antoni Sicras-Mainar, Ruth Navarro-Artieda
  Diabetes & Metabolism Journal.2015; 39(2): 173.     CrossRef
• Clinical Application of Glucagon-Like Peptide-1 Receptor Agonists
  Se Hee Min, Young Min Cho
  The Journal of Korean Diabetes.2015; 16(4): 252.     CrossRef
• Autophagy deficiency in β cells blunts incretin-induced suppression of glucagon release from α cells
  Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Hakmo Lee, Sung Soo Chung, Dong-Sik Ham, Ji-Won Kim, Kun-Ho Yoon, Kyong Soo Park, Hye Seung Jung
  Islets.2015; 7(5): e1129096.     CrossRef
• Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells
  Mi Yeon Kang, Tae Jung Oh, Young Min Cho
  Endocrinology and Metabolism.2015; 30(2): 216.     CrossRef
• Interleukin-6 CpG Methylation and Body Weight Correlate Differently in Type 2 Diabetes Patients Compared to Obese and Lean Controls
  Eva Aumueller, Marlene Remely, Hanna Baeck, Berit Hippe, Helmut Brath, Alexander G. Haslberger
  Lifestyle Genomics.2015; 8(1): 26.     CrossRef
• The glucagon-like peptide 1 receptor agonist enhances intrinsic peroxisome proliferator-activated receptor γ activity in endothelial cells
  Hirohisa Onuma, Kouichi Inukai, Atsuko Kitahara, Rie Moriya, Susumu Nishida, Toshiaki Tanaka, Hidenori Katsuta, Kazuto Takahashi, Yoshikazu Sumitani, Toshio Hosaka, Hitoshi Ishida
  Biochemical and Biophysical Research Communications.2014; 451(2): 339.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Cytokines and Hormones That Contribute to the Positive Association between Fat and Bone
  Dorit Naot, Jillian Cornish
  Frontiers in Endocrinology.2014;[Epub]     CrossRef
• Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide
  Maria Voukali, Irene Kastrinelli, Sapfo Stragalinou, Dimitra Tasiopoulou, Pinelopi Paraskevopoulou, Nicholas Katsilambros, Alexandros Kokkinos, Nicholas Tentolouris, Ioannis Ioannidis
  Journal of Diabetes Research.2014; 2014: 1.     CrossRef
• The cardiometabolic benefits of glycine: Is glycine an ‘antidote’ to dietary fructose?
  Mark F McCarty, James J DiNicolantonio
  Open Heart.2014; 1(1): e000103.     CrossRef
• Nuevos fármacos antidiabéticos: avanzando hacia el control integral de la diabesidad
  J.J. Gorgojo-Martínez
  Hipertensión y Riesgo Vascular.2014; 31(2): 45.     CrossRef
• Managing Loss of Glycemic Control in Middle-Aged Patients With Diabetes: The Role of GLP-1 Receptor Agonists in Combination-Therapy Regimens
  Thomas B. Repas
  Journal of Osteopathic Medicine.2014; 114(s52): 14.     CrossRef

Hyperthyroidism is one of the causes of thyrotoxicosis and the most common cause of hyperthyroidism in Korea is Graves disease. The diagnosis and treatment of Graves disease are different according to geographical area. Recently, the American Thyroid Association and the American Association of Clinical Endocrinologists suggested new management guidelines for hyperthyroidism. However, these guidelines are different from clinical practice in Korea and are difficult to apply. Therefore, the Korean Thyroid Association (KTA) conducted a survey of KTA members regarding the diagnosis and treatment of hyperthyroidism, and reported the consensus on the management of hyperthyroidism. In this review, we summarized the KTA report on the contemporary practice patterns in the diagnosis and management of hyperthyroidism, and compared this report with guidelines from other countries.

Citations

Citations to this article as recorded by  

• Effect of previous administration of potassium iodine and different durations of low iodine diets for radioiodine therapy on the treatment of Graves' disease in iodine-rich areas
  Mika Tamura, Kunihiro Nakada, Haruna Iwanaga, Naotoshi Fujita, Katsuhiko Kato
  European Journal of Nuclear Medicine and Molecular Imaging.2024; 51(4): 1060.     CrossRef
• Effects of altitude on thyroid disorders according to Chinese three-rung, ladder-like topography: national cross-sectional study
  Boshen Gong, Youmin Wang, Jin-an Zhang, Qiao Zhang, Jiajun Zhao, Jiashu Li, Xichang Wang, Yutong Han, Ziwei Yu, Chenyu Zhang, Bingcong Peng, Yumin Xing, Qiuxian Li, Ping Wang, Yongze Li, Weiping Teng, Zhongyan Shan
  BMC Public Health.2024;[Epub]     CrossRef
• MACE and Hyperthyroidism Treated With Medication, Radioactive Iodine, or Thyroidectomy
  Carol Chiung-Hui Peng, Yu-Jie Lin, Sun Y. Lee, Shu-Man Lin, Cheng Han, Ching-Hui Loh, Huei-Kai Huang, Elizabeth N. Pearce
  JAMA Network Open.2024; 7(3): e240904.     CrossRef
• Increased risk of incident gout in patients with hyperthyroidism: a nationwide retrospective cohort study
  Ju-Yeun Lee, So-Yeon Park, Seo Young Sohn
  Rheumatology International.2023; 44(3): 451.     CrossRef
• The Current Status of Hyperthyroidism in Korea
  Hyemi Kwon
  Endocrinology and Metabolism.2023; 38(4): 392.     CrossRef
• A machine learning-assisted system to predict thyrotoxicosis using patients’ heart rate monitoring data: a retrospective cohort study
  Kyubo Shin, Jongchan Kim, Jaemin Park, Tae Jung Oh, Sung Hye Kong, Chang Ho Ahn, Joon Ho Moon, Min Joo Kim, Jae Hoon Moon
  Scientific Reports.2023;[Epub]     CrossRef
• Immunometabolic signatures predict recovery from thyrotoxic myopathy in patients with Graves' disease
  Daiki Setoyama, Ho Yeop Lee, Ji Sun Moon, Jingwen Tian, Yea Eun Kang, Ju Hee Lee, Minho Shong, Dongchon Kang, Hyon‐Seung Yi
  Journal of Cachexia, Sarcopenia and Muscle.2022; 13(1): 355.     CrossRef
• Comparison of 99mTc Pertechnetate Thyroid Uptake Rates by Gamma Probe and Gamma Camera Methods for Differentiating Graves’ Disease and Thyroiditis
  Meihua Jin, Jonghwa Ahn, Seong-gil Jo, Jangwon Park, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Jin-Sook Ryu
  Nuclear Medicine and Molecular Imaging.2022; 56(1): 42.     CrossRef
• KSNM60 in Nuclear Endocrinology: from the Beginning to the Future
  Chae Moon Hong, Young Jin Jeong, Hae Won Kim, Byeong-Cheol Ahn
  Nuclear Medicine and Molecular Imaging.2022; 56(1): 17.     CrossRef
• Graves’ disease and the risk of Parkinson’s disease: a Korean population-based study
  Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Jinyoung Youn, Ji Oh Mok, Chul-Hee Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
  Brain Communications.2022;[Epub]     CrossRef
• Graves’ Disease and the Risk of End-Stage Renal Disease: A Korean Population-Based Study
  Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Hye Ryoun Jang, Bo-Yeon Kim, Chan-Hee Jung, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
  Endocrinology and Metabolism.2022; 37(2): 281.     CrossRef
• Evaluation and Management of Bone Health in Patients with Thyroid Diseases: a Position Statement from the Korean Thyroid Association
  A Ram Hong, Hwa Young Ahn, Bu Kyung Kim, Seong Hee Ahn, So Young Park, Min-Hee Kim, Jeongmin Lee, Sun Wook Cho, Ho-Cheol Kang
  International Journal of Thyroidology.2022; 15(1): 1.     CrossRef
• Patient Population and Test Utilization for Thyroid Function in Local Clinics and Hospitals in Korea
  Rihwa Choi, Sang Gon Lee, Eun Hee Lee
  Diagnostics.2022; 12(7): 1638.     CrossRef
• 2021 Asia-Pacific Graves’ Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves’ Disease
  Rajeev Parameswaran, Mechteld Christine de Jong, James Lee Wai Kit, Kathleen Sek, Tran Quang Nam, Tran Viet Thang, Nguyen Thy Khue, Than Than Aye, Phone Myint Tun, Timothy Cole, Julie A. Miller, Michael Villa, Benjapa Khiewvan, Sirinart Sirinvaravong, Yon
  Endocrine.2022; 79(1): 135.     CrossRef
• Graves’ disease, its treatments, and the risk of atrial fibrillation: A Korean population-based study
  Yoon Young Cho, Bongseong Kim, Dughyun Choi, Chul-Hee Kim, Dong Wook Shin, Jee Soo Kim, Seung-Jung Park, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Forty Years Together, New Leap Forward! The 40th Anniversary of the Korean Endocrine Society
  Jong Chul Won, Ki-Hyun Baek
  Endocrinology and Metabolism.2022; 37(6): 851.     CrossRef
• Evaluation of the role of thyroid scintigraphy in the differential diagnosis of thyrotoxicosis
  Carolina M. Perdomo, Marta García‐Goñi, Lidia Sancho, José J. Paricio, María D. Lozano, Magdalena de la Higuera, María Currás, Javier Arbizu, Juan C. Galofré
  Clinical Endocrinology.2021; 94(3): 466.     CrossRef
• Treatment of patients with Graves’ disease in Sweden compared to international surveys of an ‘index patient’
  Gabriel Sjölin, Kristina Byström, Mats Holmberg, Ove Törring, Selwan Khamisi, Jan Calissendorff, Mikael Lantz, Bengt Hallengren, Helena Filipsson Nyström, Tereza Planck, Göran Wallin
  Endocrinology, Diabetes & Metabolism.2021;[Epub]     CrossRef
• Secular Trends in Ablation Therapy for Graves’ Disease: An Analysis of a 15-Year Experience at a Tertiary Hospital in South Korea
  Min Joo Kim, Ye An Kim, Sun Wook Cho, Su-jin Kim, Kyu Eun Lee, Young Joo Park, Do Joon Park, Bo Youn Cho
  Journal of Clinical Medicine.2021; 10(8): 1629.     CrossRef
• Long-Term Antithyroid Drug Treatment of Graves’ Disease in Children and Adolescents: A 20-Year Single-Center Experience
  Ari Song, Su Jin Kim, Min-Sun Kim, Jiyeon Kim, Insung Kim, Ga Young Bae, Eunseop Seo, Young Seok Cho, Joon Young Choi, Sung Yoon Cho, Dong-Kyu Jin
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort
  Mi Young Song, Sunmin Park, Anjali Mishra
  Journal of Thyroid Research.2021; 2021: 1.     CrossRef
• Treatment Modality and Risk of Heart Failure in Patients With Long-Standing Graves’ Disease: A Nationwide Population-Based Cohort Study
  Eyun Song, Mina Kim, Sojeong Park, Min Jeong Park, Jung A. Kim, Eun Roh, Ji Hee Yu, Nam Hoon Kim, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Risk of Diabetes in Patients with Long-Standing Graves’ Disease: A Longitudinal Study
  Eyun Song, Min Ji Koo, Eunjin Noh, Soon Young Hwang, Min Jeong Park, Jung A Kim, Eun Roh, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
  Endocrinology and Metabolism.2021; 36(6): 1277.     CrossRef
• Diabetes and Hyperthyroidism: Is There a Causal Link?
  Sang Yong Kim
  Endocrinology and Metabolism.2021; 36(6): 1175.     CrossRef
• Incidence and Mortality of Myocardial Infarction and Stroke in Patients with Hyperthyroidism: A Nationwide Cohort Study in Korea
  Hyun Jung Kim, Taeuk Kang, Min Ji Kang, Hyeong Sik Ahn, Seo Young Sohn
  Thyroid.2020; 30(7): 955.     CrossRef
• Diagnosis and Management of Graves’ Disease in Thailand: A Survey of Current Practice
  Chutintorn Sriphrapradang
  Journal of Thyroid Research.2020; 2020: 1.     CrossRef
• The success rate of radioactive iodine therapy for Graves’ disease in iodine-replete area and affecting factors: a single-center study
  Hyunju Park, Hye In Kim, Jun Park, So Young Park, Tae Hyuk Kim, Jae Hoon Chung, Joon Young Choi, Sun Wook Kim
  Nuclear Medicine Communications.2020; 41(3): 212.     CrossRef
• Tirotoksikoz nedenli erektil disfonksiyon üzerine sildenafil etkisinin histopatolojik olarak değerlendirilmesi
  Murat ÖZDEMİR, Canberk TOMRUK, Gürkan YİĞİTTÜRK, Varlık EROL, Emel Öykü ÇETİN, Ilgın YILDIRIM ŞİMŞİR, Çiğdem YENİSEY, Yiğit UYANIKGİL, Adnan ŞİMŞİR, Özer MAKAY
  Ege Tıp Dergisi.2020; 59(3): 215.     CrossRef
• The Management of Thyroid Disease in COVID-19 Pandemic
  Won Sang Yoo, Hyun-Kyung Chung
  International Journal of Thyroidology.2020; 13(2): 65.     CrossRef
• Is Hyperthyroidism Diagnosed and Treated Appropriately in the United States?
  Ammar Asban, Sophie Dream, Brenessa Lindeman
  Advances in Surgery.2019; 53: 117.     CrossRef
• Long-term remission following antithyroid drug withdrawal in patients with Graves’ hyperthyroidism: parameters with prognostic value
  Ricardo V. García-Mayor, Paula Álvarez-Vázquez, Enrique Fluiters, Diana Valverde, Amalia Andrade
  Endocrine.2019; 63(2): 316.     CrossRef
• Safety of long-term antithyroid drug treatment? A systematic review
  F. Azizi, R. Malboosbaf
  Journal of Endocrinological Investigation.2019; 42(11): 1273.     CrossRef
• Changes in Thyroid Peroxidase and Thyroglobulin Antibodies Might Be Associated with Graves' Disease Relapse after Antithyroid Drug Therapy
  Yun Mi Choi, Mi Kyung Kwak, Sang Mo Hong, Eun-Gyoung Hong
  Endocrinology and Metabolism.2019; 34(3): 268.     CrossRef
• Prevalence and Annual Incidence of Thyroid Disease in Korea from 2006 to 2015: A Nationwide Population-Based Cohort Study
  Hyemi Kwon, Jin-hyung Jung, Kyung-Do Han, Yong-Gyu Park, Jung-Hwan Cho, Da Young Lee, Ji Min Han, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
  Endocrinology and Metabolism.2018; 33(2): 260.     CrossRef
• An update in the treatment preference for hyperthyroidism
  Obin Kwon
  Nature Reviews Endocrinology.2018; 14(7): 438.     CrossRef
• Clinical Feasibility of Monitoring Resting Heart Rate Using a Wearable Activity Tracker in Patients With Thyrotoxicosis: Prospective Longitudinal Observational Study
  Jie-Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Do Joon Park, Hak Chul Jang, Jae Hoon Moon
  JMIR mHealth and uHealth.2018; 6(7): e159.     CrossRef
• Graves' Disease Patients with Large Goiters Respond Best to Radioactive Iodine Doses of at Least 15 mCi: a Sonographic Volumetric Study
  Yun Ah Jeong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang
  International Journal of Thyroidology.2018; 11(2): 137.     CrossRef
• Chylothorax Associated with Substernal Goiter in Graves’ Disease Treated with Radioactive Iodine
  Seo Young Oh, Bo Hyun Kim, Do Young Kim, Kyu Min Lee, Min Jin Lee, Sung Su Kim, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Joo Kim
  International Journal of Endocrinology and Metabolism.2017;[Epub]     CrossRef
• Vitiligo and overt thyroid diseases: A nationwide population-based study in Korea
  Jung Min Bae, June Hyunkyung Lee, Jae Seung Yun, Byeol Han, Tae Young Han
  Journal of the American Academy of Dermatology.2017; 76(5): 871.     CrossRef
• Increased risk of thyroid diseases in patients with systemic lupus erythematosus: A nationwide population-based Study in Korea
  Jae-Seung Yun, Jung Min Bae, Ki-Jo Kim, Yu Seok Jung, Gyong Moon Kim, Hyung-Rae Kim, Jun-Seok Lee, Seung-Hyun Ko, Seon-Ah Cha, Yu-Bae Ahn, Ludmila Prokunina-Olsson
  PLOS ONE.2017; 12(6): e0179088.     CrossRef
• The Second Antithyroid Drug Treatment Is Effective in Relapsed Graves' Disease Patients: A Median 11-Year Follow-Up Study
  Ye An Kim, Sun Wook Cho, Hoon Sung Choi, Shinje Moon, Jae Hoon Moon, Kyung Won Kim, Do Joon Park, Ka Hee Yi, Young Joo Park, Bo Youn Cho
  Thyroid.2017; 27(4): 491.     CrossRef
• Free Thyroxine, Anti-Thyroid Stimulating Hormone Receptor Antibody Titers, and Absence of Goiter Were Associated with Responsiveness to Methimazole in Patients with New Onset Graves' Disease
  Hoon Sung Choi, Won Sang Yoo
  Endocrinology and Metabolism.2017; 32(2): 281.     CrossRef
• Long-Term Antithyroid Drug Treatment: A Systematic Review and Meta-Analysis
  Fereidoun Azizi, Ramin Malboosbaf
  Thyroid.2017; 27(10): 1223.     CrossRef
• The Recurrence Rate of Graves' Disease among Patients with Subclinical Thyrotoxicosis after Initial Remission with Antithyroid Agents
  Myoung Sook Shim, Soo Min Nam, Jin Sae Yoo, Hae Kyung Kim, Sang Jun Lee, Mi Young Lee
  International Journal of Thyroidology.2017; 10(2): 77.     CrossRef
• Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence
  Hwa Young Ahn, Yun Jae Chung, Bo Youn Cho
  Medicine.2017; 96(31): e7700.     CrossRef
• Recent Advances in Autoimmune Thyroid Diseases
  Won Sang Yoo, Hyun Kyung Chung
  Endocrinology and Metabolism.2016; 31(3): 379.     CrossRef
• Usefulness of Measuring Thyroid Stimulating Antibody at the Time of Antithyroid Drug Withdrawal for Predicting Relapse of Graves Disease
  Hyemi Kwon, Won Gu Kim, Eun Kyung Jang, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
  Endocrinology and Metabolism.2016; 31(2): 300.     CrossRef
• Hyperthyroidism
  Simone De Leo, Sun Y Lee, Lewis E Braverman
  The Lancet.2016; 388(10047): 906.     CrossRef
• Differentiating Graves' disease from subacute thyroiditis using ratio of serum free triiodothyronine to free thyroxine
  Chutintorn Sriphrapradang, Adikan Bhasipol
  Annals of Medicine and Surgery.2016; 10: 69.     CrossRef
• Management of hyperthyroid patients in dental emergencies: a case report
  Kyung-Jin Lee, Wonse Park, Nan-Sim Pang, Jin-Hyung Cho, Kee-Deog Kim, Bock Young Jung, Eun-Jung Kwak
  Journal of Dental Anesthesia and Pain Medicine.2016; 16(2): 147.     CrossRef
• The Presence of Thyroid-Stimulation Blocking Antibody Prevents High Bone Turnover in Untreated Premenopausal Patients with Graves’ Disease
  Sun Wook Cho, Jae Hyun Bae, Gyeong Woon Noh, Ye An Kim, Min Kyong Moon, Kyoung Un Park, Junghan Song, Ka Hee Yi, Do Joon Park, June-Key Chung, Bo Youn Cho, Young Joo Park, Jung-Eun Kim
  PLOS ONE.2015; 10(12): e0144599.     CrossRef
• Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy
  Yeoree Yang, Seawon Hwang, Minji Kim, Yejee Lim, Min-Hee Kim, Sohee Lee, Dong-Jun Lim, Moo-Il Kang, Bong-Yun Cha
  Endocrinology and Metabolism.2015; 30(4): 620.     CrossRef
• Improved quality of life in hyperthyroidism patients after surgery
  Branka Bukvic, Vladan Zivaljevic, Sandra Sipetic, Aleksandar Diklic, Katarina Tausanovic, Dragos Stojanovic, Dejan Stevanovic, Ivan Paunovic
  Journal of Surgical Research.2015; 193(2): 724.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef

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• Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep
  Giuliana Motta, Soundara Viveka Thangaraj, Vasantha Padmanabhan
  Toxics.2023; 12(1): 15.     CrossRef
• Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness
  Yong-ho Lee, Jae Hyeon Kim, So Ra Kim, Heung Yong Jin, Eun-Jung Rhee, Young Min Cho, Byung-Wan Lee
  Journal of Korean Medical Science.2017; 32(1): 60.     CrossRef
• Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease
  Gyuri Kim, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim, Salvatore Petta
  PLOS ONE.2017; 12(7): e0182202.     CrossRef

Citations

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• Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
  Inha Jung, Dae-Jeong Koo, Won-Young Lee
  Diabetes & Metabolism Journal.2024; 48(3): 327.     CrossRef
• FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity
  Óscar Osorio-Conles, Ainitze Ibarzabal, José María Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
  Journal of Clinical Medicine.2023; 12(3): 1013.     CrossRef
• Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease
  Juan Moreno-Vedia, Josefa Girona, Daiana Ibarretxe, Lluís Masana, Ricardo Rodríguez-Calvo
  Biomedicines.2022; 10(1): 197.     CrossRef
• Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals
  Marenao Tanaka, Satoko Takahashi, Yukimura Higashiura, Akiko Sakai, Masayuki Koyama, Shigeyuki Saitoh, Kazuaki Shimamoto, Hirofumi Ohnishi, Masato Furuhashi
  Journal of Diabetes Investigation.2022; 13(5): 878.     CrossRef
• New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: The Liver-Heart Axis
  Georgiana-Diana Cazac, Cristina-Mihaela Lăcătușu, Cătălina Mihai, Elena-Daniela Grigorescu, Alina Onofriescu, Bogdan-Mircea Mihai
  Life.2022; 12(8): 1189.     CrossRef
• Association between the liver fat score (LFS) and cardiovascular diseases in the national health and nutrition examination survey 1999–2016
  Chun-On Lee, Hang-Long Li, Man-Fung Tsoi, Ching-Lung Cheung, Bernard Man Yung Cheung
  Annals of Medicine.2021; 53(1): 1067.     CrossRef
• Relationship Between Fatty Acid Binding Protein 4 and Liver Fat in Individuals at Increased Cardiometabolic Risk
  Ricardo Rodríguez-Calvo, Juan Moreno-Vedia, Josefa Girona, Daiana Ibarretxe, Neus Martínez-Micaelo, Jordi Merino, Nuria Plana, Lluis Masana
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective
  Eun-Jung Rhee
  Endocrinology and Metabolism.2019; 34(3): 226.     CrossRef
• Serum adipocyte fatty acid‐binding protein levels: An indicator of non‐alcoholic fatty liver disease in Chinese individuals
  Yiting Xu, Xiaojing Ma, Xiaoping Pan, Xingxing He, Yufei Wang, Yuqian Bao
  Liver International.2019; 39(3): 568.     CrossRef
• Clinical Characteristics of Non-Alcoholic Fatty Liver Disease Based on Analyses from the Kangbuk Samsung Health Study
  Eun-Jung Rhee
  The Journal of Korean Diabetes.2017; 18(2): 81.     CrossRef
• The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function
  Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Seong Yong Lim, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
  BMC Pulmonary Medicine.2016;[Epub]     CrossRef
• Liver fatty acid-binding protein as a diagnostic marker for non-alcoholic fatty liver disease
  Erdem Akbal, Erdem Koçak, Ömer Akyürek, Seyfettin Köklü, Hikmetullah Batgi, Mehmet Şenes
  Wiener klinische Wochenschrift.2016; 128(1-2): 48.     CrossRef
• High‐methionine diets accelerate atherosclerosis by HHcy‐mediated FABP4 gene demethylation pathway via DNMT1 in ApoE−/− mice
  An-Ning Yang, Hui-Ping Zhang, Yue Sun, Xiao-Ling Yang, Nan Wang, Guangrong Zhu, Hui Zhang, Hua Xu, Sheng-Chao Ma, Yue Zhang, Gui-Zhong Li, Yue-Xia Jia, Jun Cao, Yi-Deng Jiang
  FEBS Letters.2015; 589(24PartB): 3998.     CrossRef
• Metabolic Health Is More Important than Obesity in the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Retrospective Study
  Min-Kyung Lee, Eun-Jung Rhee, Min Chul Kim, Byung Sub Moon, Jeong In Lee, Young Seok Song, Eun Na Han, Hyo Sun Lee, Yoonjeong Son, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
  Endocrinology and Metabolism.2015; 30(4): 522.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Noninvasive Markers for the Diagnosis of Nonalcoholic Fatty Liver Disease
  Sang Yong Kim
  Endocrinology and Metabolism.2013; 28(4): 280.     CrossRef

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• Potential antimicrobial activity of camel milk as a traditional functional food against foodborne pathogens in vivo and in vitro
  Amro Abdelazez, Sherif Melak, Heba Abdelmotaal, Garsa Alshehry, Huda Al-jumayi, Eman Algarni, Xiang-Chen Meng
  Food Science and Technology International.2024; 30(3): 239.     CrossRef
• Effects of home‐cage elevation on behavioral tests in mice
  Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
  Brain and Behavior.2024;[Epub]     CrossRef
• Anaesthesia-induced Changes in Genomic Expression Leading to Neurodegeneration
  Khalid Saad Alharbi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Mohammed Albratty, Asim Najmi, Gaurav Gupta
  CNS & Neurological Disorders - Drug Targets.2024; 23(4): 411.     CrossRef
• Stress integration by an ascending adrenergic-melanocortin circuit
  Connor Laule, Nilufer Sayar-Atasoy, Iltan Aklan, Hyojin Kim, Tayfun Ates, Debbie Davis, Deniz Atasoy
  Neuropsychopharmacology.2024; 49(9): 1361.     CrossRef
• Stress-induced changes in cognitive function and intestinal barrier integrity can be ameliorated by venlafaxine and synbiotic supplementations
  Sarawut Lapmanee, Nattapon Supkamonseni, Sakkarin Bhubhanil, Nattakan Treesaksrisakul, Chaiyos Sirithanakorn, Mattaka Khongkow, Katawut Namdee, Piyaporn Surinlert, Chittipong Tipbunjong, Prapimpun Wongchitrat
  PeerJ.2024; 12: e17033.     CrossRef
• Effects of prenatal THC vapor exposure on body weight, glucose metabolism, and feeding behaviors in chow and high-fat diet fed rats
  Catherine Hume, Samantha L. Baglot, Lucia Javorcikova, Savannah H. M. Lightfoot, Jessica Scheufen, Matthew N. Hill
  International Journal of Obesity.2024; 48(7): 981.     CrossRef
• The inhalation effect of Osmanthus fragrans var. Aurantiacus on physiological parameters in chronically stressed rats
  Moon Yeon Youn, Jin-Ju Cho, Seong Jun Hong, Seong Min Jo, Hyangyeon Jeong, Sojeong Yoon, Younglan Ban, Hyeonjin Park, Jae Kyeom Kim, Young Jun Kim, Eui-Cheol Shin
  Food Chemistry: X.2024; 22: 101304.     CrossRef
• Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences
  Soraia Silva, Joana Bicker, S. Fialho, Susana Cunha, Amílcar Falcão, Ana Fortuna
  Biochemical Pharmacology.2024; 223: 116184.     CrossRef
• Translational models of stress and resilience: An applied neuroscience methodology review
  Zeynep Seda Albayrak, Andreia Vaz, Joeri Bordes, Selen Ünlü, Milou S.C. Sep, Christiaan H. Vinkers, Luisa Pinto, Hale Yapici-Eser
  Neuroscience Applied.2024; 3: 104064.     CrossRef
• Prenatal restraint stress affects early neurobehavioral response and oxidative stress in mice pups.
  Oumaima Essaidi, Meriem Laaroussi, Hafsa Malqui, Laila Berroug, Hammou Anarghou, Hamadi Fetoui, Fatiha Chigr
  Behavioural Brain Research.2024; 468: 115025.     CrossRef
• Cerebrovascular dysfunction and depressive symptoms in preclinical models: insights from a scoping review
  Nithin J. Menon, Clara Sun, Jashnoor Chhina, Brayden D. Halvorson, Jefferson C. Frisbee, Stephanie J. Frisbee
  Journal of Applied Physiology.2024; 136(6): 1352.     CrossRef
• Improved Memory and Lower Stress Levels in Male Mice Co-Housed with Ovariectomized Female Mice
  Layung Sekar Sih Wikanthi, Johan Forsström, Birgit Ewaldsson, Vilborg Palsdottir, Therése Admyre
  Animals.2024; 14(10): 1503.     CrossRef
• The effects of Gastrodia elata on anxiety-like behavior in mice
  Lan-Qiao He, Jia-Yu Lin, Ming-Zhi Yu, Peng-Yu Fan, Cen-Jie He, Ting-Ting Zhao
  All Life.2024;[Epub]     CrossRef
• Chronic stress intensify PTZ-induced seizures by triggering neuroinflammation and oxidative stress
  Jehan Zeb Khan, Syeda Rida Zainab, Mujeeb Ur Rehman, Muhammad Abid, Muhammad Usama Mazhar, Fawad Ali Shah, Muhammad Khalid Tipu
  Biochemical and Biophysical Research Communications.2024; 729: 150333.     CrossRef
• Subregion-specific transcriptomic profiling of rat brain reveals sex-distinct gene expression impacted by adolescent stress
  Kristen N. Krolick, Jingyi Cao, Evelyn M. Gulla, Meeta Bhardwaj, Samantha J. Marshall, Ethan Y. Zhou, Andor J. Kiss, Fouad Choueiry, Jiangjiang Zhu, Haifei Shi
  Neuroscience.2024; 553: 19.     CrossRef
• Sex-dependent astrocyte reactivity: Unveiling chronic stress-induced morphological changes across multiple brain regions
  Ariel Y. Zhang, Elias Elias, Melissa T. Manners
  Neurobiology of Disease.2024; 200: 106610.     CrossRef
• A Light-Responsive Neural Circuit Suppresses Feeding
  Hailan Liu, Na Qu, Natalia Valdez Gonzalez, Marco A. Palma, Huamin Chen, Jiani Xiong, Abhinav Choubey, Yongxiang Li, Xin Li, Meng Yu, Hesong Liu, Longlong Tu, Nan Zhang, Na Yin, Kristine Marie Conde, Mengjie Wang, Jonathan Carter Bean, Junying Han, Nikola
  The Journal of Neuroscience.2024; 44(30): e2192232024.     CrossRef
• Pharmacological inhibition of histone deacetylase alleviates chronic unpredictable stress induced atherosclerosis and endothelial dysfunction via upregulation of BDNF
  Mujeeba Rehman, Vipul Agarwal, Rishabh Chaudhary, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Anand Kumar, Sanjay Singh, Vikas Mishra
  Biochemical and Biophysical Research Communications.2024; 735: 150485.     CrossRef
• Plasma leptin levels are lower in females, but not males, with ketamine use disorder
  Ming-Chyi Huang, Li-Jung Chiang, Wan-Hsi Chien, Tung-Hsia Liu, Chun-Hsin Chen, Yu-Li Liu
  The American Journal of Drug and Alcohol Abuse.2024; : 1.     CrossRef
• Acyl-CoA binding protein for the experimental treatment of anorexia
  Hui Chen, Stéphanie Moriceau, Adrien Joseph, Francois Mailliet, Sijing Li, Virginie Tolle, Philibert Duriez, Roland Dardennes, Sylvère Durand, Vincent Carbonnier, Gautier Stoll, Allan Sauvat, Sylvie Lachkar, Fanny Aprahamian, Carolina Alves Costa Silva, H
  Science Translational Medicine.2024;[Epub]     CrossRef
• Feedforward inhibition of stress by brainstem neuropeptide Y neurons
  Yan Zhang, Jiayi Shen, Famin Xie, Zhiwei Liu, Fangfang Yin, Mingxiu Cheng, Liang Wang, Meiting Cai, Herbert Herzog, Ping Wu, Zhi Zhang, Cheng Zhan, Tiemin Liu
  Nature Communications.2024;[Epub]     CrossRef
• Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
  Mario Sánchez-Rubio, Lorena Abarzúa-Catalán, Ana del Valle, Maxs Méndez-Ruette, Natalia Salazar, Jacinta Sigala, Soledad Sandoval, María Inés Godoy, Alejandro Luarte, Lara J. Monteiro, Roberto Romero, Mahesh A. Choolani, Úrsula Wyneken, Sebastián E. Illan
  Biological Research.2024;[Epub]     CrossRef
• Chronic stress-mediated dysregulations in inflammatory, immune and oxidative circuitry impairs the therapeutic response of methotrexate in experimental autoimmune disease models
  Rishabh Chaudhary, Mohd Akhtar Azam, Bhavana Dowand, Alpana Singh, Mujeeba Rehman, Vipul Agarwal, Anand Kumar, Arjun Singh Kaushik, Sukriti Srivastava, Siddhi Srivastava, Vikas Mishra
  Naunyn-Schmiedeberg's Archives of Pharmacology.2024;[Epub]     CrossRef
• Stress exacerbates pancreatic cancer both directly and indirectly by creating an immunosuppressive environment
  Takahiro Ikeda, Tomohiko Adachi, Takayuki Tanaka, Daisuke Miyamoto, Hajime Imamura, Hajime Matsushima, Kazuo Yamamoto, Masaaki Hidaka, Kengo Kanetaka, Susumu Eguchi
  Journal of Hepato-Biliary-Pancreatic Sciences.2023; 30(7): 935.     CrossRef
• Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice
  Shuo Wu, Kuan Ning, Yujun Wang, Lesha Zhang, Jinggen Liu
  European Journal of Pharmacology.2023; 942: 175532.     CrossRef
• Assessment of Stress Caused by Environmental Changes for Improving the Welfare of Laboratory Beagle Dogs
  Gwang-Hoon Lee, Woori Jo, Tae-Ku Kang, Taeho Oh, KilSoo Kim
  Animals.2023; 13(6): 1095.     CrossRef
• Butein ameliorates chronic stress induced atherosclerosis via targeting anti-inflammatory, anti-fibrotic and BDNF pathways
  Mujeeba Rehman, Rishabh Chaudhary, Sonu Rajput, Vipul Agarwal, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Rohit Singh, Irfan Aziz, Sanjay Singh, Vikas Mishra
  Physiology & Behavior.2023; 267: 114207.     CrossRef
• Impact of exercise on brain-bone marrow interactions in chronic stress: potential mechanisms preventing stress-induced hypertension
  Thu Van Nguyen, Ko Yamanaka, Keisuke Tomita, Jasenka Zubcevic, Sabine S. S. Gouraud, Hidefumi Waki
  Physiological Genomics.2023; 55(5): 222.     CrossRef
• Effect of mobile phone radiofrequency electromagnetic radiations on oxidative stress and feeding behaviour in Sprague Dawley (SD) rats
  Pravallika Pagadala, Vinutha Shankar M S, Sumathi M E
  Indian Journal of Physiology and Pharmacology.2023; 67: 131.     CrossRef
• Mechanical loading and autophagy: A study on the BoNT-A injection-induced condylar cartilage degeneration
  Siyu Hou, Sisi Peng, Hongwei Dai, Jinlin Song, Ling Xu, Jianping Zhou, Lingjie Li
  Archives of Biochemistry and Biophysics.2023; 749: 109788.     CrossRef
• Continuous deep brain stimulation of the nucleus accumbens reduces food intake but does not affect body weight in mice fed a high-fat diet
  Harold F. Hounchonou, Hui Tang, Raik Paulat, Andrea Kühn, Joachim Spranger, Christoph van Riesen, Lukas Maurer
  Scientific Reports.2023;[Epub]     CrossRef
• Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis
  Rishabh Chaudhary, Ajay Prasad, Vipul Agarwal, Mujeeba Rehman, Anand Kumar, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Vikas Mishra
  International Immunopharmacology.2023; 125: 111046.     CrossRef
• Venlafaxine and synbiotic attenuated learned fear-like behavior and recognition memory impairment in immobilized-stressed rats
  Sarawut Lapmanee, Sakkarin Bhubhanil, Siriwan Sriwong, Mattaka Khongkow, Katawut Namdee, Prapimpun Wongchitrat, Pawin Pongkorpsakol
  Physiology and Pharmacology.2023; 27(2): 171.     CrossRef
• Gonadotropin levels reduced in seven days immobilization stress-induced depressive-like behavior in female rats
  Zafer Sahin, Alpaslan Ozkurkculer, Omer Faruk Kalkan, Funda Gulcu Bulmus, Ozgur Bulmus, Selim Kutlu
  Journal of Basic and Clinical Physiology and Pharmacology.2022; 33(2): 199.     CrossRef
• Impact of the Sound of Magnetic Resonance Imaging Pulse Sequences in Awake Mice
  Joana Almeida, Frederico Severo, Daniel Nunes
  Journal of Applied Animal Welfare Science.2022; 25(1): 75.     CrossRef
• Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice
  Edem Ekpenyong Edem, Blessing Eghosa Ihaza, Adedamola Adediran Fafure, Azeez Olakunle Ishola, Kate Eberechukwu Nebo, Linus Anderson Enye, Elizabeth Toyin Akinluyi
  Drug Metabolism and Personalized Therapy.2022; 37(2): 177.     CrossRef
• Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress
  Dalia Murra, Kathryn L. Hilde, Anne Fitzpatrick, Pamela M. Maras, Stanley J. Watson, Huda Akil
  Neurobiology of Stress.2022; 17: 100437.     CrossRef
• VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors
  Soo Ji Baek, Jin Sung Park, Jinhyun Kim, Yukio Yamamoto, Keiko Tanaka-Yamamoto
  eLife.2022;[Epub]     CrossRef
• Repeated Restraint Stress and Binge Alcohol during Adolescence Induce Long-Term Effects on Anxiety-like Behavior and the Expression of the Endocannabinoid System in Male Rats
  Laura Sánchez-Marín, María Flores-López, Ana L. Gavito, Juan Suárez, Francisco Javier Pavón-Morón, Fernando Rodríguez de Fonseca, Antonia Serrano
  Biomedicines.2022; 10(3): 593.     CrossRef
• “Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin
  Xi Chen, Jing Dong, Qian Jiao, Xixun Du, Mingxia Bi, Hong Jiang
  Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
• Pharmacological Enhancement of Extinction Retention in Non-stressed Adolescent Rats but Not Those Exposed to Chronic Corticosterone
  Anthea A. Stylianakis, Kathryn D. Baker, Rick Richardson
  Frontiers in Neuroscience.2022;[Epub]     CrossRef
• The effect of choline alphoscerate on non spatial memory and neuronal differentiation in a rat model of dual stress
  Hyo Jeong Yu, Ye Lin Kim, Min Jung Kim, Jung Mee Park, So Young Park, Shi Nae Park, Dong Won Yang
  Brain Research.2022; 1786: 147900.     CrossRef
• Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments
  Adrian M. Stankiewicz, Aneta Jaszczyk, Joanna Goscik, Grzegorz R. Juszczak
  Progress in Neuro-Psychopharmacology and Biological Psychiatry.2022; 119: 110558.     CrossRef
• Repeated restraint stress modifies fatty acid and amino acid metabolism in the mouse skin
  Yume KITAGAWA, Kaho HAYAKAWA, Daichi OIKAWA, Kazuki IKEDA, Maki IKEDA, Daiki HARADA, Mitsuhiro FURUSE
  Journal of Veterinary Medical Science.2022; 84(4): 511.     CrossRef
• Antidiabetic Properties and Toxicological Assessment of Antidesma celebicum Miq: Ethanolic Leaves Extract in Sprague–Dawley Rats
  Raysa Y. Pratiwi, Berna Elya, Heri Setiawan, Roshamur C. Forestrania, Rizna T. Dewi, Kim Wei Chan
  Advances in Pharmacological and Pharmaceutical Sciences.2022; 2022: 1.     CrossRef
• Proteomic and microbiota analyses of the oral cavity during psychological stress
  Durga Paudel, Yasuhiro Kuramitsu, Osamu Uehara, Tetsuro Morikawa, Koki Yoshida, Sarita Giri, Syed Taufiqul Islam, Takao Kitagawa, Tadashi Kondo, Kazuki Sasaki, Hirofumi Matsuoka, Hiroko Miura, Yoshihiro Abiko, Jon M. Jacobs
  PLOS ONE.2022; 17(5): e0268155.     CrossRef
• Long-lasting effects of postweaning sleep deprivation on cognitive function and social behaviors in adult mice
  Boya Huang, Binhuang Sun, Rui Yang, Shihao Liang, Xinrui Li, Yi Guo, Qian Meng, Yaling Fu, Wenshuya Li, Penghui Zhao, Miao Gong, Yun Shi, Li Song, Sheng Wang, Fang Yuan, Haishui Shi
  Neuropharmacology.2022; 215: 109164.     CrossRef
• High Housing Density-Induced Chronic Stress Diminishes Ovarian Reserve via Granulosa Cell Apoptosis by Angiotensin II Overexpression in Mice
  Jihyun Kim, Sooseong You
  International Journal of Molecular Sciences.2022; 23(15): 8614.     CrossRef
• The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer’s disease
  Zohreh Taghadosi, Asadollah Zarifkar, Vahid Razban, Hadi Aligholi
  Metabolic Brain Disease.2022; 37(8): 2699.     CrossRef
• Validity of the peak velocity to detect physical training improvements in athymic mice
  Maurício Beitia Kraemer, Karen Christine Silva, Camila Cunha França Kraemer, Juliana Silva Pereira, Ivan Gustavo Masseli dos Reis, Denise Gonçalves Priolli, Leonardo Henrique Dalcheco Messias
  Frontiers in Physiology.2022;[Epub]     CrossRef
• Nicotine exposure through breastfeeding affects brain‐derived neurotrophic factor and synaptic proteins levels in the brain of stressed adult female mice
  Antonio Alves Pereira Júnior, Gabriel Estevam Santos de Amorim, Raphael Caio Tamborelli Garcia, Jéssyca Milene Ribeiro, Alessandra Oliveira Silva, Carolina Aparecida de Faria Almeida, Carla Speroni Ceron, Silvia Graciela Ruginsk, José Antunes‐Rodrigues, L
  International Journal of Developmental Neuroscience.2022; 82(8): 758.     CrossRef
• Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy
  Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Gergely Berta, Valér Csernus, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszner
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress
  Ana Paula Mendes-Silva, Thomas Damien Prevot, Mounira Banasr, Etienne Sibille, Breno Satler Diniz
  Frontiers in Cellular Neuroscience.2022;[Epub]     CrossRef
• Chronic Inhibition of Aggressive Behavior Induces Behavioral Change in Mice
  Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara, Enzo Emanuele
  Behavioural Neurology.2022; 2022: 1.     CrossRef
• Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via N-methyl-D-aspartate receptor modulation in mice
  Bo-Ram Lee, Ju-Hyun Lee, Yong-Hyun Ko, Jee-Yeon Seo, Kwang-Hyun Hur, Young-Jung Kim, Seon-Kyung Kim, Seong-Eon Kim, Seok-Yong Lee, Choon-Gon Jang
  Journal of Ginseng Research.2021; 45(2): 254.     CrossRef
• The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction
  B. A. Kermath, A. M. Vanderplow, K. J. Bjornson, E. N. Seablom, A. M. Novak, C. R. Bernhardt, M. E. Cahill
  Molecular Psychiatry.2021; 26(7): 3223.     CrossRef
• Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain
  Swati Sahoo, Prashant S. Kharkar, Niteshkumar U. Sahu, Brijesh S.
  Phytotherapy Research.2021; 35(3): 1399.     CrossRef
• Changes in nitric oxide, carbon monoxide, hydrogen sulfide and male reproductive hormones in response to chronic restraint stress in rats
  Amira Moustafa
  Free Radical Biology and Medicine.2021; 162: 353.     CrossRef
• Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats
  Fatma Z. Sakhri, Naoki Adachi, Sakina Zerizer, Yusuke Ohashi, Hideshi Ikemoto, Mana Tsukada, Zahia Kabouche, Tadashi Hisamitsu, Masataka Sunagawa
  Phytotherapy Research.2021; 35(4): 2074.     CrossRef
• Restraint stress induces uterine microenvironment disorder in mice during early pregnancy through the β2-AR/cAMP/PKA pathway
  Jiayin Lu, Guanhui Liu, Zixu Wang, Jing Cao, Yaoxing Chen, Yulan Dong
  Stress.2021; 24(5): 514.     CrossRef
• A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling
  Gavin M. Meade, Lily S. Charron, Lantz W. Kilburn, Zhe Pei, Hoau-Yan Wang, Siobhan Robinson
  Physiology & Behavior.2021; 234: 113286.     CrossRef
• Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway
  Na Liu, Yifan Wu, Xin Wen, Peng Li, Fei Lu, Hong Shang
  Journal of Molecular Medicine.2021; 99(3): 403.     CrossRef
• Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice
  Jinho Kim, Yoo-Hun Suh, Keun-A Chang
  Molecular Brain.2021;[Epub]     CrossRef
• Amelioration on oxidative stress, testosterone, and cortisol levels after administration of Vitamins C and E in albino rats with chronic variable stress
  Nanik Hidayatik, Agus Purnomo, Faisal Fikri, Muhammad Thohawi Elziyad Purnama
  Veterinary World.2021; 14(1): 137.     CrossRef
• Decreased expression of AKAP4 and TyrPho proteins in testis, epididymis, and spermatozoa with low sexual performance of mice induced by modified CUMS
  Pannawat Choowong‐in, Jintana Sattayasai, Chanasorn Poodendaen, Sitthichai Iamsaard
  Andrologia.2021;[Epub]     CrossRef
• Chronic Mild Unpredictable Stress and High-Fat Diet Given during Adolescence Impact Both Cognitive and Noncognitive Behaviors in Young Adult Mice
  Stephen L. P. Lippi
  Brain Sciences.2021; 11(2): 260.     CrossRef
• Additional Assessment of Fecal Corticosterone Metabolites Improves Visual Rating in the Evaluation of Stress Responses of Laboratory Rats
  Tina Kroll, Nikola Kornadt-Beck, Angela Oskamp, David Elmenhorst, Chadi Touma, Rupert Palme, Andreas Bauer
  Animals.2021; 11(3): 710.     CrossRef
• COVID-19 Stress and Food Intake: Protective and Risk Factors for Stress-Related Palatable Food Intake in U.S. Adults
  Jennifer R. Sadler, Gita Thapaliya, Elena Jansen, Anahys H. Aghababian, Kimberly R. Smith, Susan Carnell
  Nutrients.2021; 13(3): 901.     CrossRef
• Effects of Long‐Term Exposure of Intermediate Frequency Magnetic Fields (20 kHz, 360 µT) on the Development, Pathological Findings, and Behavior of Female Mice
  Alexander Lerchl, Karen Drees (née Grote), Isabel Gronau, Dirk Fischer, Julia Bauch, Axel Hoppe
  Bioelectromagnetics.2021; 42(4): 309.     CrossRef
• Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model
  Ulrike Kogel, Ee Tsin Wong, Justyna Szostak, Wei Teck Tan, Francesco Lucci, Patrice Leroy, Bjoern Titz, Yang Xiang, Tiffany Low, Sin Kei Wong, Emmanuel Guedj, Nikolai V. Ivanov, Walter K. Schlage, Manuel C. Peitsch, Arkadiusz Kuczaj, Patrick Vanscheeuwijc
  Journal of Applied Toxicology.2021; 41(10): 1598.     CrossRef
• Neuroprotective Effects of Acrocomia aculeata Pulp Oil Microcapsules on Rats Subjected to Chronic Stress
  Ana Cristina Jacobowski, Eduardo Benedetti Parisotto, Leonardo Recena Aydos, Roberta Serafim de Souza, Sandra Viveros, Ana Laura Colín-Gonzalez, Iandara Schettert Silva, Eliana Janet Sanjinez-Argandoña, Danilo Wilhelm Filho, Abel Santamaría-Del Angel, Mar
  Journal of Medicinal Food.2021; 24(10): 1068.     CrossRef
• Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects
  Lise Verbruggen, Lindsay Sprimont, Eduard Bentea, Pauline Janssen, Azzedine Gharib, Lauren Deneyer, Laura De Pauw, Olaya Lara, Hideyo Sato, Charles Nicaise, Ann Massie
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• Effects of Achillea tenuifolia Lam. hydro-alcoholic extract on anxiety-like behavior and reproductive parameters in rat model of chronic restraint stress
  Y Bagheri, E Fathi, A Maghoul, S Moshtagh, K Mokhtari, A Abdollahpour, S Montazersaheb, A Bagheri
  Human & Experimental Toxicology.2021; 40(11): 1852.     CrossRef
• Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
  Junhel Dalanon, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Parimal Chavan, Yoshitaka Suzuki, Kazuo Okura, Hiroyoshi Séi, Yoshizo Matsuka
  Scientific Reports.2021;[Epub]     CrossRef
• Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain
  Siobhan Robinson, Allison S. Mogul, Elisa M. Taylor-Yeremeeva, Amber Khan, Anthony D. Tirabassi, Hoau-Yan Wang
  Neuroscience.2021; 473: 142.     CrossRef
• Improved Training and Semen Collection Outcomes Using the Closed Box Chair for Macaques
  Lisa A. Houser, Cathy Ramsey, Fernanda M. de Carvalho, Breanna Kolwitz, Chelsey Naito, Kristine Coleman, Carol B. Hanna
  Animals.2021; 11(8): 2384.     CrossRef
• Ethologically relevant repeated acute social stress induces maternal neglect in the lactating female mouse
  Zachary J. Rosinger, Heather S. Mayer, Jacqueline I. Geyfen, Mable K. Orser, Danielle S. Stolzenberg
  Developmental Psychobiology.2021;[Epub]     CrossRef
• Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming
  Xiaoguo Zheng, Zhenhua Li, Guishuan Wang, Hanshu Wang, Yuchuan Zhou, Xinzhi Zhao, C. Yan Cheng, Yunbo Qiao, Fei Sun
  Cell Discovery.2021;[Epub]     CrossRef
• Involvement of Ghrelin Dynamics in Stress-Induced Eating Disorder: Effects of Sex and Aging
  Chihiro Yamada
  International Journal of Molecular Sciences.2021; 22(21): 11695.     CrossRef
• Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model
  Nora Weegh, Eva Zentrich, Dietmar Zechner, Birgitta Struve, Laura Wassermann, Steven Roger Talbot, Simone Kumstel, Miriam Heider, Brigitte Vollmar, André Bleich, Christine Häger, Dragan Hrncic
  PLOS ONE.2021; 16(12): e0261662.     CrossRef
• Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake
  Go Eun Ha, Eunji Cheong
  Experimental Neurobiology.2021; 30(6): 375.     CrossRef
• Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats
  Fahima Fellah, Rédha Djenidi, Imen Chebout
  Psychiatry Investigation.2020; 17(2): 130.     CrossRef
• Physical and Physiological Indicators of Welfare in Guinea Pigs (Cavia porcellus) Serving as Ambassador Animals
  David M. Powell, Corinne P. Kozlowski, John Clark, Alice Seyfried, Eli Baskir, Ashley D. Franklin
  Animals.2020; 10(5): 815.     CrossRef
• 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression
  Xi-Xi Li, Yun Yu, Xiu-Yuan Lang, Cheng-Yong Jiang, Rongfeng Lan, Xiao-Yan Qin
  Neuroscience.2020; 430: 25.     CrossRef
• Anxiolytic activity of Coriandrum sativum seeds aqueous extract on chronic restraint stressed mice and effect on brain neurotransmitters
  Swati Sahoo, S. Brijesh
  Journal of Functional Foods.2020; 68: 103884.     CrossRef
• Vitamin C supplementation during chronic variable stress exposure modulates contractile functions of testicular artery and sperm parameters in male Wistar rats
  Shakiru Ademola Salami, Hussein Mofomosara Salahdeen, Oyinlola Toluwani Moronkola, Babatunde Adekunle Murtala, Yinusa Raji
  Middle East Fertility Society Journal.2020;[Epub]     CrossRef
• A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia
  Na Qu, Yanlin He, Chunmei Wang, Pingwen Xu, Yongjie Yang, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Zheng Sun, Makoto Fukuda, Yi Li, Qing Tian, Yong Xu
  Molecular Psychiatry.2020; 25(5): 1006.     CrossRef
• Mirogabalin prevents repeated restraint stress-induced dysfunction in mice
  Takashi Iwai, Akinori Kikuchi, Misa Oyama, Shun Watanabe, Mitsuo Tanabe
  Behavioural Brain Research.2020; 383: 112506.     CrossRef
• A Systematic Review of In Vitro and In Vivo Radio Frequency Exposure Methods
  Jared W. Hansen, Ellen M. Swartz, Jerika D. Cleveland, Sajid M. Asif, Benjamin Brooks, Benjamin D. Braaten, Daniel L. Ewert
  IEEE Reviews in Biomedical Engineering.2020; 13: 340.     CrossRef
• Diminished ovarian reserve induced by chronic unpredictable stress in C57BL/6 mice
  Lingyun Gao, Fangui Zhao, Yang Zhang, Wenjun Wang, Qi Cao
  Gynecological Endocrinology.2020; 36(1): 49.     CrossRef
• Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
  Menizibeya O. Welcome, Nikos E. Mastorakis
  Pharmacological Research.2020; 157: 104769.     CrossRef
• Anaesthetic-dependent changes in gene expression following acute and chronic exposure in the rodent brain
  Dannielle H. Upton, Kata Popovic, Roger Fulton, Michael Kassiou
  Scientific Reports.2020;[Epub]     CrossRef
• Comparative analysis of acute and chronic stress-induced neurobehavioral alteration and liver injury in mice
  Tae Woo Oh, Kwang-Youn Kim, Hyun Ju Do, Young-Woo Kim, Kwang-Il Park
  Molecular & Cellular Toxicology.2020; 16(4): 367.     CrossRef
• The impact of chronic stress on energy metabolism
  Michael A. van der Kooij
  Molecular and Cellular Neuroscience.2020; 107: 103525.     CrossRef
• In vitro and in vivo studies of nanoparticles of chitosan-Pandanus tectorius fruit extract as new alternative treatment for hypercholesterolemia via Scavenger Receptor Class B type 1 pathway
  Efriyana Oksal, Inten Pangestika, Tengku Sifzizul Tengku Muhammad, Habsah Mohamad, Hermansyah Amir, Murni Nur Islamiah Kassim, Yosie Andriani
  Saudi Pharmaceutical Journal.2020; 28(10): 1263.     CrossRef
• Behavioral, metabolic, and renal outcomes of 1-month isolation in adolescent male Dahl salt-sensitive rats
  Oksana Nikolaienko, Elena Isaeva, Vladislav Levchenko, Oleg Palygin, Alexander Staruschenko
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2020; 319(6): R684.     CrossRef
• The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders
  Eva Maria Fritz, Nicolas Singewald, Dimitri De Bundel
  Frontiers in Synaptic Neuroscience.2020;[Epub]     CrossRef

• Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology

  
  Lingyun Gao, Yang Zhang, Huangfang Xu, Fangui Zhao, Wenjun Wang
  Drug Design, Development and Therapy.2020; Volume 14: 4975.     CrossRef
• Vitamin C protects against chronic social isolation stress-induced weight gain and depressive-like behavior in adult male rats
  Alireza Najaf Dulabi, Zeinab Shakerin, Nasrin Mehranfard, Maedeh Ghasemi
  Endocrine Regulations.2020; 54(4): 266.     CrossRef
• Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high-fat diet-fed mouse model
  Sung Bae Lee, Hyeong Geug Kim, Jin Seok Lee, Won Yong Kim, Myong Min Lee, Yun Hee Kim, Jung Ok Lee, Hyeon Soo Kim, Chang Gue Son
  American Journal of Physiology-Gastrointestinal and Liver Physiology.2019; 317(6): G811.     CrossRef
• Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats
  Qiuxia Pan, Jiajia Wu, Yueyun Liu, Xiaojuan Li, Jiaxu Chen
  Molecules.2019; 24(3): 480.     CrossRef
• miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior
  Sydney Aten, Chloe E. Page, Anisha Kalidindi, Kelin Wheaton, Anzela Niraula, Jon P. Godbout, Kari R. Hoyt, Karl Obrietan
  Neuropharmacology.2019; 144: 256.     CrossRef
• Oxytocin involves in chronic stress-evoked melanoma metastasis via β-arrestin 2-mediated ERK signaling pathway
  Haoyi Ji, Na Liu, Jing Li, Dawei Chen, Dan Luo, Qian Sun, Yingchun Yin, Yanli Liu, Bing Bu, Xiaoyang Chen, Jingxin Li
  Carcinogenesis.2019; 40(11): 1395.     CrossRef
• Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain
  Salina Akter, Hiroyuki Sasaki, Kazi Rasel Uddin, Yuko Ikeda, Hiroki Miyakawa, Shigenobu Shibata
  Life Sciences.2019; 216: 119.     CrossRef
• Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats
  Atef Tadros Fahim, Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Bassam Mohamed Ali
  Archives of Biochemistry and Biophysics.2019; 665: 152.     CrossRef
• Centella asiaticaPrevents Increase of Hippocampal Tumor Necrosis Factor-αIndependently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress
  Mawaddah Ar Rochmah, Ika Murti Harini, Dian Eurike Septyaningtrias, Dwi Cahyani Ratna Sari, Rina Susilowati
  BioMed Research International.2019; 2019: 1.     CrossRef
• Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats
  Kimino Minagawa, Shin-ichi Yamada, Ayano Suzuki, Saeko Ta, Toshio Kumai, Fernand Lambein, Kuniko Kusama-Eguchi
  Environmental Toxicology and Pharmacology.2019; 72: 103245.     CrossRef
• Chronic Stress Combined with a Fructose Diet Reduces Hypothalamic Insulin Signaling and Antioxidative Defense in Female Rats
  Sanja Kovačević, Jelena Nestorov, Gordana Matić, Ivana Elaković
  Neuroendocrinology.2019; 108(4): 278.     CrossRef
• Gut-Brain Neuroendocrine Signaling Under Conditions of Stress—Focus on Food Intake-Regulatory Mediators
  Andreas Stengel, Yvette Taché
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Chronic unpredictable mild stress-induced depressive-like behavior and dysregulation of brain levels of biogenic amines in Drosophila melanogaster
  Stífani Machado Araujo, Marcia Rósula Poetini, Vandreza Cardoso Bortolotto, Shanda de Freitas Couto, Franciane Cabral Pinheiro, Luana Barreto Meichtry, Francielli Polet de Almeida, Elize Aparecida Santos Musachio, Mariane Trindade de Paula, Marina Prigol
  Behavioural Brain Research.2018; 351: 104.     CrossRef
• Melatonin attenuates chronic immobilization stress-induced muscle atrophy in rats: Influence on lactate-to-pyruvate ratios and Na+/K+ ATPase activity
  Eman S.H. Abd Allah, Ahmed M. Mahmoud
  Pathophysiology.2018; 25(4): 353.     CrossRef
• Chronic stress effects and their reversibility on the Fallopian tubes and uterus in rats
  S. Divyashree, H. N. Yajurvedi
  Reproduction, Fertility and Development.2018; 30(2): 380.     CrossRef
• Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice
  Carina Bodden, Sophie Siestrup, Rupert Palme, Sylvia Kaiser, Norbert Sachser, S. Helene Richter
  Behavioural Brain Research.2018; 336: 261.     CrossRef
• Repeated Neck Restraint Stress Bidirectionally Modulates Excitatory Transmission in the Dentate Gyrus and Performance in a Hippocampus-dependent Memory Task
  Jadwiga Spyrka, Grzegorz Hess
  Neuroscience.2018; 379: 32.     CrossRef
• Stress-induced strain and brain region-specific activation of LINE-1 transposons in adult mice
  Ugo Cappucci, Giulia Torromino, Assunta Maria Casale, Jeremy Camon, Fabrizio Capitano, Maria Berloco, Andrea Mele, Sergio Pimpinelli, Arianna Rinaldi, Lucia Piacentini
  Stress.2018; 21(6): 575.     CrossRef
• The involvement of Rhopr-CRF/DH in feeding and reproduction in the blood-gorging insect Rhodnius prolixus
  Shirin Mollayeva, Ian Orchard, Angela B. Lange
  General and Comparative Endocrinology.2018; 258: 79.     CrossRef
• Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans
  Muhammad I. ul Akbar Yousufzai, Elia S. Harmatz, Mohsin Shah, Muhammad O. Malik, Ki A. Goosens
  Translational Psychiatry.2018;[Epub]     CrossRef
• Sub-Chronic Stress Exacerbates the Pro-Thrombotic Phenotype in BDNFVal/Met Mice: Gene-Environment Interaction in the Modulation of Arterial Thrombosis
  Leonardo Sandrini, Alessandro Ieraci, Patrizia Amadio, Fabrizio Veglia, Maurizio Popoli, Francis S. Lee, Elena Tremoli, Silvia Stella Barbieri
  International Journal of Molecular Sciences.2018; 19(10): 3235.     CrossRef
• Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice
  Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara
  BMC Neuroscience.2018;[Epub]     CrossRef
• Chronic stress induced duration dependent alterations in immune system and their reversibility in rats
  H.N. Sarjan, H.N. Yajurvedi
  Immunology Letters.2018; 197: 31.     CrossRef
• Chronic stress alters adrenal clock function in a sexually dimorphic manner
  Matthew Stagl, Mary Bozsik, Christopher Karow, David Wertz, Ian Kloehn, Savin Pillai, Paul J Gasser, Marieke R Gilmartin, Jennifer A Evans
  Journal of Molecular Endocrinology.2018; 60(2): 55.     CrossRef
• Impaired Growth Performance and Testicular Cells Apoptosis Following Restraint Stress in Adult Hypothyroid Mice
  Asif Mehfooz, Quanwei Wei, Mohamed Babo Fadlalla, Farman Ali Siyal, Kuldeep Dhama, Dagan Mao, Fangxiong Shi
  International Journal of Pharmacology.2017; 13(6): 541.     CrossRef
• Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke
  Zidan Zhao, Lin Kooi Ong, Sarah Johnson, Michael Nilsson, Frederick R Walker
  Journal of Cerebral Blood Flow & Metabolism.2017; 37(12): 3709.     CrossRef
• Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis
  Leonie Stolz, Amin Derouiche, Kavi Devraj, Frank Weber, Robert Brunkhorst, Christian Foerch
  Journal of Neuroinflammation.2017;[Epub]     CrossRef
• Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring
  Roxana Karbaschi, Homeira Zardooz, Fariba Khodagholi, Leila Dargahi, Mina Salimi, FatemehSadat Rashidi
  Nutrition & Metabolism.2017;[Epub]     CrossRef
• The effect of chronic noise stress on serum levels of cortisol, gonadotropins, and sexual hormones at implantation time of mice
  Alireza Shafiei, Hassan Ehteram, Hossein Akbari, Masoud Motalebi Kashani, Mandana Beigi, Javad Amini Mahabadi, Tahere Mazoochi
  Comparative Clinical Pathology.2017; 26(4): 779.     CrossRef
• Aging rather than stress strongly influences amino acid metabolisms in the brain and genital organs of female mice
  Momoko Kodaira, Mao Nagasawa, Takeshi Yamaguchi, Hiromi Ikeda, Kimie Minaminaka, Vishwajit S. Chowdhury, Shinobu Yasuo, Mitsuhiro Furuse
  Mechanisms of Ageing and Development.2017; 162: 72.     CrossRef
• Histone deacetylase-2 is involved in stress-induced cognitive impairment via histone deacetylation and PI3K/AKT signaling pathway modification
  Jie Wu, Cui Liu, Ling Zhang, Chun-Hui Qu, Xiao-Long Sui, Hua Zhu, Lan Huang, Yan-Feng Xu, Yun-Lin Han, Chuan Qin
  Molecular Medicine Reports.2017; 16(2): 1846.     CrossRef
• High Hydrostatic Pressure Extract of Ginger Exerts Antistress Effects in Immobilization-Stressed Rats
  Sohee Moon, Mak-Soon Lee, Sunyoon Jung, Bori Kang, Seog-Young Kim, Seonyoung Park, Hye-Yeon Son, Chong-Tai Kim, Young-Hee Jo, In-Hwan Kim, Young Soon Kim, Yangha Kim
  Journal of Medicinal Food.2017; 20(9): 864.     CrossRef
• Insulin, not glutamine dipeptide, reduces lipases expression and prevents fat wasting and weight loss in Walker 256 tumor-bearing rats
  Hely de Morais, Flaviane de Fatima Silva, Francemilson Goulart da Silva, Milene Ortiz Silva, Maria Fernanda Rodrigues Graciano, Maria Isabel Lovo Martins, Ângelo Rafael Carpinelli, Tânia Longo Mazucco, Roberto Barbosa Bazotte, Helenir Medri de Souza
  European Journal of Pharmacology.2017; 806: 67.     CrossRef
• HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels
  Karolina Pytka, Monika Głuch-Lutwin, Magdalena Kotańska, Elżbieta Żmudzka, Magdalena Jakubczyk, Anna Waszkielewicz, Paulina Janiszewska, Maria Walczak
  Behavioural Brain Research.2017; 333: 54.     CrossRef
• The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels
  Chong Chen, Shin Nakagawa, Yan An, Koki Ito, Yuji Kitaichi, Ichiro Kusumi
  Frontiers in Neuroendocrinology.2017; 44: 83.     CrossRef
• Long-term chronic stress exposure induces PCO phenotype in rat
  S Divyashree, H N Yajurvedi
  Reproduction.2016; 152(6): 765.     CrossRef
• Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation
  Byung Soo Kong, Soo Jung Im, Yang Jong Lee, Yoon Hee Cho, Yu Ri Do, Jung Woo Byun, Cheol Ryong Ku, Eun Jig Lee, Maria Cristina Vinci
  PLOS ONE.2016; 11(3): e0149394.     CrossRef
• Effects of long-term chronic stress on the lymphoid organs and blood leukocytes of the rat (Rattus norvegicus)
  S. Divyashree, H.N. Sarjan, H.N. Yajurvedi
  Canadian Journal of Zoology.2016; 94(2): 137.     CrossRef
• Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe
  Keitaro Yoshida, Yu Mimura, Ryosuke Ishihara, Hiroshi Nishida, Yuji Komaki, Tomohito Minakuchi, Tomokazu Tsurugizawa, Masaru Mimura, Hideyuki Okano, Kenji F. Tanaka, Norio Takata
  Journal of Neuroscience Methods.2016; 274: 38.     CrossRef
• Integrated circuits and molecular components for stress and feeding: implications for eating disorders
  J. A. Hardaway, N. A. Crowley, C. M. Bulik, T. L. Kash
  Genes, Brain and Behavior.2015; 14(1): 85.     CrossRef
• The Use of Animal Models to Decipher Physiological and Neurobiological Alterations of Anorexia Nervosa Patients
  Mathieu Méquinion, Christophe Chauveau, Odile Viltart
  Frontiers in Endocrinology.2015;[Epub]     CrossRef
• Kososan, but not milnacipran, elicits antidepressant‐like effects in a novel psychological stress‐induced mouse model of depression
  Atsushi Hori, Naoki Ito, Tetsuro Oikawa, Toshihiko Hanawa
  Traditional & Kampo Medicine.2015; 2(1): 1.     CrossRef
• Electroconvulsive stimulation, but not chronic restraint stress, causes structural alterations in adult rat hippocampus—A stereological study
  Mikkel V. Olesen, Gitta Wörtwein, Bente Pakkenberg
  Hippocampus.2015; 25(1): 72.     CrossRef
• Dopamine release in the lateral hypothalamus is stimulated by α-MSH in both the anticipatory and consummatory phases of feeding
  Romain Legrand, Nicolas Lucas, Jonathan Breton, Pierre Déchelotte, Sergueï O. Fetissov
  Psychoneuroendocrinology.2015; 56: 79.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Contrasting mechanisms by which social isolation and restraint impair healing in male mice
  Leah M. Pyter, Linglan Yang, Cassandra McKenzie, José M. da Rocha, C. Sue Carter, Bin Cheng, Christopher G. Engeland
  Stress.2014; 17(3): 256.     CrossRef
• G Protein-Coupled Estrogen Receptor-1 Is Involved in the Protective Effect of Protocatechuic Aldehyde against Endothelial Dysfunction
  Byung Soo Kong, Yoon Hee Cho, Eun Jig Lee, Rajesh Mohanraj
  PLoS ONE.2014; 9(11): e113242.     CrossRef

Citations

Citations to this article as recorded by  

• Senoinflammation as the underlying mechanism of aging and its modulation by calorie restriction
  Sang Gyun Noh, Hyun Woo Kim, Seungwoo Kim, Ki Wung Chung, Young-Suk Jung, Jeong-Hyun Yoon, Byung Pal Yu, Jaewon Lee, Hae Young Chung
  Ageing Research Reviews.2024; 101: 102503.     CrossRef
• Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia
  Lei Sun, He Yang, Dong He, Jian Chen, Zhiqiang Dong, Shaoxiang Luo, Huiting Liang, Yu Cao, Bingcheng Cai, Min Zhang
  Cell Death & Disease.2022;[Epub]     CrossRef
• The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products
  Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ching-Yu Yen, Hsueh-Wei Chang
  Antioxidants.2022; 11(9): 1845.     CrossRef
• Treadmill Exercise Reduces Neuroinflammation, Glial Cell Activation and Improves Synaptic Transmission in the Prefrontal Cortex in 3 × Tg-AD Mice
  Lianwei Mu, Dongdong Xia, Jiajia Cai, Boya Gu, Xiaojie Liu, Vladislav Friedman, Qing-Song Liu, Li Zhao
  International Journal of Molecular Sciences.2022; 23(20): 12655.     CrossRef
• Lysosomes in T Cell Immunity and Aging
  Jun Jin, Huimin Zhang, Cornelia M. Weyand, Jorg J. Goronzy
  Frontiers in Aging.2021;[Epub]     CrossRef
• FOXO1 deficiency impairs proteostasis in aged T cells
  Jun Jin, Xuanying Li, Bin Hu, Chulwoo Kim, Wenqiang Cao, Huimin Zhang, Cornelia M. Weyand, Jorg J. Goronzy
  Science Advances.2020;[Epub]     CrossRef
• Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations
  Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh, Hoon Ryu, Jae-Bong Park
  Redox Biology.2020; 32: 101446.     CrossRef
• Metabolic features and regulation in cell senescence
  So Mee Kwon, Sun Mi Hong, Young-Kyoung Lee, Seongki Min, Gyesoon Yoon
  BMB Reports.2019; 52(1): 5.     CrossRef
• DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
  Nicole Schwab, Karl Grenier, Lili-Naz Hazrati
  Acta Neuropathologica Communications.2019;[Epub]     CrossRef
• Oxidative stress-induced downregulation of glycogen synthase kinase 3 beta in fetal membranes promotes cellular senescence†
  Narmada Lavu, Lauren Richardson, Enkhtuya Radnaa, Talar Kechichian, Rheanna Urrabaz-Garza, Samantha Sheller-Miller, Elizabeth Bonney, Ramkumar Menon
  Biology of Reproduction.2019; 101(5): 1018.     CrossRef
• Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice
  Hui Ying Li, Yoon Sin Oh, Ji-Woong Choi, Ji Yong Jung, Hee-Sook Jun
  Kidney International.2017; 91(6): 1362.     CrossRef
• Expression of senescence-associated genes in multipotent mesenchymal stromal cells during long-term cultivation at various hypoxic levels
  M. V. Lobanova, A. Y. Ratushnyy, L. B. Buravkova
  Doklady Biochemistry and Biophysics.2016; 470(1): 326.     CrossRef
• The PI3K pathway in B cell metabolism
  Julia Jellusova, Robert C. Rickert
  Critical Reviews in Biochemistry and Molecular Biology.2016; 51(5): 359.     CrossRef
• Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice
  Xiao-Ying Zhang, Jiang-Bei Cao, Li-Ming Zhang, Yun-Feng Li, Wei-Dong Mi
  Journal of Neuroinflammation.2015;[Epub]     CrossRef
• Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3β inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance
  Kyoung Min Kim, Kuy-Sook Lee, Gha Young Lee, Hyunjin Jin, Eunice Sung Durrance, Ho Seon Park, Sung Hee Choi, Kyong Soo Park, Young-Bum Kim, Hak Chul Jang, Soo Lim
  Molecular and Cellular Endocrinology.2015; 409: 1.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart
  Phyllis-Jean Linton, Marilyn L. Thoman
  Immunology Letters.2014; 162(1): 290.     CrossRef

Citations

Citations to this article as recorded by  

• Common carotid artery intima media thickness (CIMT) in patients with prediabetes and newly diagnosed type 2 diabetes mellitus
  Antoaneta Gateva, Yavor Assyov, Vera Karamfilova, Zdravko Kamenov
  Journal of Diabetes and its Complications.2024; 38(7): 108766.     CrossRef
• Carotid atherosclerosis: An independent risk factor for small fiber nerve dysfunction in patients with type 2 diabetes mellitus
  Simin Guo, Yali Jing, Chenxi Li, Dalong Zhu, Weimin Wang
  Journal of Diabetes Investigation.2023; 14(2): 289.     CrossRef
• Evaluating Diagnostic Ultrasound of the Vagus Nerve as a Surrogate Marker for Autonomic Neuropathy in Diabetic Patients
  Bianka Heiling, Adriana Karl, Nadin Fedtke, Nicolle Müller, Christof Kloos, Alexander Grimm, Hubertus Axer
  Medicina.2023; 59(3): 525.     CrossRef
• Albuminuria but not low eGFR is closely associated with atherosclerosis in patients with type 2 diabetes: an observational study
  Jun-Wei Wang, Jiang-Feng Ke, Zhi-Hui Zhang, Jun-Xi Lu, Lian-Xi Li
  Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
• Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy
  Josep Julve, Joana Rossell, Eudald Correig, Marina Idalia Rojo-Lopez, Nuria Amigó, Marta Hernández, Alicia Traveset, Marc Carbonell, Nuria Alonso, Didac Mauricio, Esmeralda Castelblanco
  Nutrients.2022; 14(19): 3932.     CrossRef
• The relationship between carotid disease and retinopathy in diabetes: a systematic review
  Jocelyn J. Drinkwater, Timothy M. E. Davis, Wendy A. Davis
  Cardiovascular Diabetology.2020;[Epub]     CrossRef
• Carotid Disease and Retinal Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes: The Fremantle Diabetes Study Phase II
  Jocelyn J. Drinkwater, Fred K. Chen, Alison M. Brooks, Brad T. Davis, Angus W. Turner, Timothy M.E. Davis, Wendy A. Davis
  Diabetes Care.2020; 43(12): 3034.     CrossRef
• Diabetic foot – invalidating complication of diabetes mellitus
  Oana Manuela Spălăţelu, Sergiu Chirila, Leonard Gurgas, Vasile Sârbu
  Medic.ro.2019; 3(129): 40.     CrossRef
• Clinical factors associated with the recovery of cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus
  Ji Eun Jun, Seung-Eun Lee, Min Sun Choi, Sung Woon Park, You-Cheol Hwang, Jae Hyeon Kim
  Cardiovascular Diabetology.2019;[Epub]     CrossRef
• Association of carotid intima-media thickness with exercise tolerance test in type 2 diabetic patients
  Ali Momeni, Abdolmajid Taheri, Maryam Mansuri, Ali Bazdar, Morteza Sedehi, Masoud Amiri
  IJC Heart & Vasculature.2018; 21: 74.     CrossRef
• Cardiac autonomic neuropathy may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus
  Sarka Mala, Veronika Potockova, Lucie Hoskovcova, Pavlina Pithova, Marek Brabec, Jaroslava Kulhankova, Radan Keil, Lucie Riedlbauchova, Jan Broz
  Diabetes Research and Clinical Practice.2017; 134: 139.     CrossRef
• Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes
  Akihiko Ando, Michiaki Miyamoto, Kazuhiko Kotani, Kenta Okada, Shoichiro Nagasaka, Shun Ishibashi
  Journal of Diabetes Research.2017; 2017: 1.     CrossRef
• Cardiac Involvement in Peripheral Neuropathies
  Ahmet Z. Burakgazi, Soufian AlMahameed
  Journal of Clinical Neuromuscular Disease.2016; 17(3): 120.     CrossRef
• The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
  Chan-Hee Jung, Sang-Hee Jung, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
  Diabetes and Vascular Disease Research.2015; 12(5): 342.     CrossRef
• Atorvastatin Treatment for Carotid Intima-Media Thickness in Chinese Patients With Type 2 Diabetes
  Na Fang, Wei Han, Dandan Gong, Zou Chen, Yu Fan
  Medicine.2015; 94(44): e1920.     CrossRef
• Cardiovascular complications in patients with autonomic failure
  Valeria Milazzo, Cristina Di Stefano, Alberto Milan, Agnese Ravera, Gabriele Sobrero, Luca Sabia, Franco Veglio, Simona Maule
  Clinical Autonomic Research.2015; 25(3): 133.     CrossRef
• Association of heart rate with albuminuria in a general adult population: the 2011 Korea National Health and Nutrition Examination Survey
  H. S. Choi, J. W. Hong, J. H. Lee, J. H. Noh, D. J. Kim
  Internal Medicine Journal.2015; 45(4): 428.     CrossRef
• Type 2 diabetes-associated carotid plaque burden is increased in patients with retinopathy compared to those without retinopathy
  Núria Alonso, Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Jordi Sanahuja, Marta Hernández, Angels Betriu, Carmen Jurjo, Elvira Fernández, Didac Mauricio
  Cardiovascular Diabetology.2015;[Epub]     CrossRef
• Letter: Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes (Endocrinol Metab 2013;28:309-19, Chan-Hee Jung et al.)
  Hyun-Kyung Chung
  Endocrinology and Metabolism.2014; 29(1): 101.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Clinical utility of serum beta-2-microglobulin as a predictor of diabetic complications in patients with type 2 diabetes without renal impairment
  M.K. Kim, K.-J. Yun, H.J. Chun, E.-H. Jang, K.-D. Han, Y.-M. Park, K.-H. Baek, K.-H. Song, B.-Y. Cha, C.S. Park, H.-S. Kwon
  Diabetes & Metabolism.2014; 40(6): 459.     CrossRef
• Association between Brachial-Ankle pulse wave velocity and cardiac autonomic neuropathy in type 2 diabetes
  Nan Wu, Xiaoling Cai, Kuanping Ye, Yintao Li, Min He, Weiwei Zhao, Renming Hu
  Diabetology & Metabolic Syndrome.2014;[Epub]     CrossRef

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• Diversities of Mechanism in Patients with VHL Syndrome and diabetes: A Report of Two Cases and Literature Review
  Yanlei Wang, Zhaoxiang Liu, Wenhui Zhao, Chenxiang Cao, Luqi Xiao, Jianzhong Xiao
  Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 1611.     CrossRef
• Retinal hemangioblastoma in a patient with Von Hippel-Lindau disease: A case report and literature review
  Yikeng Huang, Weiwen Hu, Xionggao Huang
  Frontiers in Oncology.2022;[Epub]     CrossRef
• Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms
  Claudia von Arx, Monica Capozzi, Elena López-Jiménez, Alessandro Ottaiano, Fabiana Tatangelo, Annabella Di Mauro, Guglielmo Nasti, Maria Lina Tornesello, Salvatore Tafuto
  Journal of Clinical Medicine.2019; 8(9): 1277.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies in the absence of exogenous insulin administration. Some drugs containing sulfhydryl compounds are known to initiate the onset of IAS. A 67-year-old female who had diabetes for 5 years visited the outpatient clinic at our institution due to diabetic peripheral polyneuropathy. She was prescribed α-lipoic acid (ALA), which contains two sulfur atoms. Two weeks later, she complained of recurrent hypoglycemic symptoms. We detected a high level of insulin and high titers of insulin autoantibodies. Her human leukocyte antigen (HLA) genotype included the DRB1*0406 allele, which indicates a high level of susceptibility to IAS. She was treated with prednisolone. After this episode, she experienced two more hypoglycemic events after taking ALA for diabetic neuropathy in other hospitals. As ALA can be used to treat diabetic peripheral polyneuropathy, physician discretion is advised based on the possibility of IAS due to ALA in diabetic patients.

Citations

Citations to this article as recorded by  

• HLA Alleles Associate with Insulin Autoimmune Syndrome
  Dan Yao, Jiefeng Jiang, Qianyun Zhou, Caiyun Feng, Jianping Chu, Zhiyan Chen, Jie Yang, Jinying Xia, Yujia Chen
  Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3463.     CrossRef
• Long-term follow-up after discharge witnesses a slow decline of insulin autoantibodies in patients with insulin autoimmune syndrome complicated with Grave’s disease: a report of two cases
  Lili Zhao, Jinzhi He, Shandong Ye, Chao Chen, Jie Zhu, Chunchun Xiao, Tingni Wu, Zhicheng Liu
  BMC Endocrine Disorders.2023;[Epub]     CrossRef
• Postprandial hyperinsulinemic hypoglycemia
  A. A. Akmedova, F. O. Ushanova
  FOCUS. Endocrinology.2023; 4(3): 74.     CrossRef
• Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review
  Nahid Najafi, Soghra Mehri, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
  Phytotherapy Research.2022; 36(6): 2300.     CrossRef
• Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features
  Umberto Capece, Simona Moffa, Ilaria Improta, Gianfranco Di Giuseppe, Enrico Celestino Nista, Chiara M. A. Cefalo, Francesca Cinti, Alfredo Pontecorvi, Antonio Gasbarrini, Andrea Giaccari, Teresa Mezza
  Nutrients.2022; 15(1): 18.     CrossRef
• Analysis of the clinical characteristics of insulin autoimmune syndrome induced by alpha‐lipoic acid
  Zuojun Li, Yanhong Su, Dan Yi, Cuifang Wu, Weijin Fang, Chunjiang Wang
  Journal of Clinical Pharmacy and Therapeutics.2021; 46(5): 1295.     CrossRef
• Scientific opinion on the relationship between intake of alpha‐lipoic acid (thioctic acid) and the risk of insulin autoimmune syndrome
  Dominique Turck, Jacqueline Castenmiller, Stefaan de Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Helle Katrine Knutsen, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri,
  EFSA Journal.2021;[Epub]     CrossRef
• Management of Insulin Autoimmune Hypoglycaemia: Single‐centre experience from Western India with systematic review of world literature
  Muniraj Patel, Ravikumar Shah, Swati Ramteke‐Jadhav, Virendra Patil, Shivendra Kumar Patel, Anurag Lila, Nalini Shah, Tushar Bandgar
  Clinical Endocrinology.2020; 92(5): 409.     CrossRef
• Glucose Changes in a Patient With Insulin Autoimmune Syndrome Demonstrated by Continuous Glucose Monitoring
  Shi-Dou Lin, Shang-Ren Hsu
  AACE Clinical Case Reports.2019; 5(1): e35.     CrossRef
• Insulin Autoimmune Syndrome in a 25-Year-Old, Previously Healthy Kuwaiti Man
  Einas Alrashidi, Thamer Alessa
  Case Reports in Endocrinology.2019; 2019: 1.     CrossRef
• Insulin autoimmune syndrome in an Argentine woman taking α-lipoic acid: A case report and review of the literature
  Valentina Izzo, Carla Greco, Diana Corradini, Marco Infante, Maria Teresa Staltari, Maria Romano, Alfonso Bellia, Davide Lauro, Luigi Uccioli
  SAGE Open Medical Case Reports.2018;[Epub]     CrossRef
• Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome
  David Church, Luís Cardoso, Richard G Kay, Claire L Williams, Bernard Freudenthal, Catriona Clarke, Julie Harris, Myuri Moorthy, Efthmia Karra, Fiona M Gribble, Frank Reimann, Keith Burling, Alistair J K Williams, Alia Munir, T Hugh Jones, Dagmar Führer,
  The Journal of Clinical Endocrinology & Metabolism.2018; 103(10): 3845.     CrossRef
• Current Status of Health Foods Including Their Interactions with Drugs and Adverse Events
  Yoshiro Saito
  YAKUGAKU ZASSHI.2018; 138(12): 1511.     CrossRef
• Autoimmune hypoglycaemia caused by alpha-lipoic acid: a rare condition in Caucasian patients
  A Veltroni, G Zambon, S Cingarlini, M V Davì
  Endocrinology, Diabetes & Metabolism Case Reports.2018;[Epub]     CrossRef
• GLP‑1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF‑κB signaling pathways in streptozotocin‑induced diabetic rats
  Jingjing Ma, Min Shi, Xiangcheng Zhang, Xiaoning Liu, Juan Chen, Ridong Zhang, Xingzhou Wang, Hong Zhang
  International Journal of Molecular Medicine.2018;[Epub]     CrossRef
• Insulin autoimmune syndrome associated with alpha-lipoic acid in a young woman with no concomitant disease
  Sang Bae Lee, Min Young Lee, Ji Hong You, Seong Han Kim, Ji Sun Nam
  Yeungnam University Journal of Medicine.2017; 34(1): 115.     CrossRef
• The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis
  Adel A.A. Ismail
  Clinical Chemistry and Laboratory Medicine (CCLM).2016; 54(11): 1715.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef

Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.

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• Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function
  Jeonghoon Ha, Joonyub Lee, Jin Yu, Hakyoung Park, Jiwon Shinn, Seung-Hwan Lee, Jae-Hyoung Cho, Hun-Sung Kim
  The Korean Journal of Internal Medicine.2024; 39(4): 650.     CrossRef
• Is Kidney Stone Associated with Thyroid Disease? The United States National Health and Nutrition Examination Survey 2007-2018
  Wenya Xue, Zihan Xue, Yanbing Liu, Pan Yin, Luyu Liu, Shen’ao Qu, Shaobo Wu, Chuance Yang
  Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(11): 1323.     CrossRef
• Case report: Rhabdomyolysis and kidney injury in a statin-treated hypothyroid patient–kill two birds with one stone
  Wen-Fang Chiang, Jenq-Shyong Chan, Po-Jen Hsiao, Shih-Hua Lin
  Frontiers in Medicine.2022;[Epub]     CrossRef
• Secondary dyslipidemia: its treatments and association with atherosclerosis
  Hidekatsu Yanai, Hiroshi Yoshida
  Global Health & Medicine.2021; 3(1): 15.     CrossRef
• Hypothyroidism-associated rhabdomyolysis
  Fahmi Yousef Khan, Theeb Osama Sulaiman, Raza Ali Akbar
  Imam Journal of Applied Sciences.2021; 6(2): 31.     CrossRef
• Phenotyping of Korean patients with better-than-expected efficacy of moderate-intensity statins using tensor factorization
  Jingyun Choi, Yejin Kim, Hun-Sung Kim, In Young Choi, Hwanjo Yu, Katriina Aalto-Setala
  PLOS ONE.2018; 13(6): e0197518.     CrossRef
• Discovery of potential novel microsomal triglyceride transfer protein inhibitors via virtual screening of pharmacophore modelling and molecular docking
  Ludi Jiang, Yusu He, Ganggang Luo, Yongqiang Yang, Gongyu Li, Yanling Zhang
  Molecular Simulation.2016; 42(15): 1223.     CrossRef
• Statin‐related aminotransferase elevation according to baseline aminotransferases level in real practice in Korea
  H.‐S. Kim, S. H. Lee, H. Kim, S.‐H. Lee, J. H. Cho, H. Lee, H. W. Yim, S.‐H. Kim, I.‐Y. Choi, K.‐H. Yoon, J. H. Kim
  Journal of Clinical Pharmacy and Therapeutics.2016; 41(3): 266.     CrossRef
• Creatinine as predictor value of mortality and acute kidney injury in rhabdomyolysis
  R. Baeza‐Trinidad, A. Brea‐Hernando, S. Morera‐Rodriguez, Y. Brito‐Diaz, S. Sanchez‐Hernandez, L. El Bikri, E. Ramalle‐Gomara, J. L. Garcia‐Alvarez
  Internal Medicine Journal.2015; 45(11): 1173.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of dyslipidemia: mind the gaps!
  Vasilios G. Athyros, Niki Katsiki, Asterios Karagiannis, Dimitri P. Mikhailidis
  Current Medical Research and Opinion.2014; 30(9): 1701.     CrossRef

Due to the increased prevalence of papillary thyroid carcinoma (PTC), difficult cases and unexpected events have become more common during long-term follow-up. Herein we reported four cases that exhibited poor progress during long-term follow-up. All the cases were diagnosed with PTC and treated with total thyroidectomy before several years, and the patients had been newly diagnosed with recurrent and metastatic PTC. These four cases included recurred PTC with invasion of large blood vessels, a concomitant second malignancy, malignant transformation, and refractoriness to treatment. Physicians should closely monitor patients to promptly address unforeseen circumstances during PTC follow-up, including PTC recurrence and metastasis. Furthermore, we suggest that the development of a management protocol for refractory or terminal PTC is also warranted.

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• Induction of epithelial-mesenchymal transition in thyroid follicular cells is associated with cell adhesion alterations and low-dose hyper-radiosensitivity
  Ankit Mathur, Vijayakumar Chinnadurai, Param Jit Singh Bhalla, Sudhir Chandna
  Tumor Biology.2023; 45(1): 95.     CrossRef
• Thyroglobulin Level in Fine-Needle Aspirates for Preoperative Diagnosis of Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma: Two Different Cutoff Values According to Serum Thyroglobulin Level
  Min Ji Jeon, Won Gu Kim, Eun Kyung Jang, Yun Mi Choi, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong, Jung Hwan Baek, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim
  Thyroid.2015; 25(4): 410.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef

Papillary thyroid carcinoma (PTC) is a common affliction of the thyroid gland, accounting for 70% to 80% of all thyroid cancers, whereas mucosa-associated lymphoid tissue (MALT) lymphoma of the thyroid gland is uncommon. The simultaneous occurrence of both malignancies is extremely rare. We report the case of a patient with both PTC and MALT lymphoma in the setting of Hashimoto thyroiditis. An 81-year-old female patient was first admitted with goiter and hoarseness, which was attributed to an ultrasonographic thyroid nodule. Subsequent fine-needle aspirate, interpreted as suspicious of papillary thyroid cancer, prompted total thyroidectomy. MALT lymphoma was an incidental postsurgical finding, coexisting with PTC in the setting of Hashimoto thyroiditis. Although the development of MALT lymphoma is very rare, patients with longstanding Hashimoto thyroiditis should undergo careful surveillance for both malignancies.

Citations

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• Two lymphoma histotypes and papillary thyroid carcinoma coexisting on Hashimoto ground: a case report and review of the literature
  Igor Iskra, Maja Ilić Tomaš, Tatjana Bogović Crnčić, Edvin Kukić, Ita Hadžisejdić, Manuela Avirović, Neva Girotto
  Diagnostic Pathology.2024;[Epub]     CrossRef
• Thyroid papillary carcinoma combined with primary follicular lymphoma: a case report
  Ting Xu, Li Wu, Hua Ye, Shuai Luo, Jinjing Wang
  Diagnostic Pathology.2024;[Epub]     CrossRef
• Thyroid Mucosa-associated Lymphoid Tissue Lymphoma Presenting as Intermediate-risk Thyroid Nodule with Positive KRAS Mutation
  Nipith Charoenngam, Mehmet Sercan Marangoz, Simon Lamothe, Benjamin C. James
  AACE Clinical Case Reports.2023; 9(2): 44.     CrossRef
• Coexistence of tuberculosis and extranodal marginal zone lymphoma of the thyroid gland: Case report and literature review
  Sami Akbulut, Khaled Demyati, Ridvan Yavuz, Nilgun Sogutcu, Emine Turkmen Samdanci, Yusuf Yagmur
  Annals of Medicine and Surgery.2022; 78: 103861.     CrossRef
• Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation
  Massimo Ralli, Diletta Angeletti, Marco Fiore, Vittorio D'Aguanno, Alessandro Lambiase, Marco Artico, Marco de Vincentiis, Antonio Greco
  Autoimmunity Reviews.2020; 19(10): 102649.     CrossRef
• Mucosa-Associated Lymphoid Tissue Lymphoma of the Thyroid Gland: A Systematic Review of the Literature
  Evangelos Karvounis, Ioannis Kappas, Anna Angelousi, Georgios-Marios Makris, Eva Kassi
  European Thyroid Journal.2020; 9(1): 11.     CrossRef
• Primary thyroid MALToma– a rare diagnosis of an unassuming thyroid nodule
  Pragya Shrestha, Kimberly Aderhold, Sharon Swierczynski, Catherine Lin, Ronald Herb
  Journal of Community Hospital Internal Medicine Perspectives.2018; 8(1): 42.     CrossRef
• Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis
  Maria Trovato, Giuseppe Giuffrida, Antonino Seminara, Simone Fogliani, Vittorio Cavallari, Rosaria Maddalena Ruggeri, Alfredo Campennì
  Archives of Endocrinology and Metabolism.2017; 61(6): 643.     CrossRef
• Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report
  Qiong Wu, Yu-xin Jiang, Jun-chao Guo, Yu Xiao, Xiao Yang, Rui-na Zhao, Xing-jian Lai, Shen-ling Zhu, Xiao-yan Zhang, Bo Zhang
  Chinese Medical Sciences Journal.2016; 31(1): 54.     CrossRef
• Coexistence of papillary thyroid microcarcinoma and mucosa-associated lymphoid tissue lymphoma in a context of Hashimoto's thyroiditis
  Saul Levy-Blitchtein, Stefany Plasencia-Rebata, Domingo Morales Luna, Juana del Valle Mendoza
  Asian Pacific Journal of Tropical Medicine.2016; 9(8): 812.     CrossRef
• Synchronous Occurrence of Papillary Thyroid Carcinoma and Mucosa-Associated Lymphoid Tissue Lymphoma: a Single Case Report
  Jun Suk Byun, Hye Yoon Lee, Ki Won Chun, Dae Sung Yoon
  International Journal of Thyroidology.2016; 9(2): 195.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Primary mucosa-associated lymphoid tissue lymphoma of the thyroid with concomitant papillary carcinoma
  Shaakir Hasan, Aruna Turaka
  Journal of Radiotherapy in Practice.2014; 13(4): 490.     CrossRef
• G Protein-Coupled Estrogen Receptor-1 Is Involved in the Protective Effect of Protocatechuic Aldehyde against Endothelial Dysfunction
  Byung Soo Kong, Yoon Hee Cho, Eun Jig Lee, Rajesh Mohanraj
  PLoS ONE.2014; 9(11): e113242.     CrossRef