Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > BROWSE ARTICLES > Previous issues
30 Previous issues
Filter
Filter
Article type
Keywords
Authors
Volume 30(4); December 2015
Prev issue Next issue
Review Articles
Bone Metabolism
Growth and Age-Related Abnormalities in Cortical Structure and Fracture Risk
Ego Seeman
Endocrinol Metab. 2015;30(4):419-428.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.419
  • 4,058 View
  • 61 Download
  • 23 Web of Science
  • 22 Crossref
AbstractAbstract PDFPubReader   

Vertebral fractures and trabecular bone loss have dominated thinking and research into the pathogenesis and the structural basis of bone fragility during the last 70 years. However, 80% of all fractures are non-vertebral and occur at regions assembled using large amounts of cortical bone; only 20% of fractures are vertebral. Moreover, ~80% of the skeleton is cortical and ~70% of all bone loss is cortical even though trabecular bone is lost more rapidly than cortical bone. Bone is lost because remodelling becomes unbalanced after midlife. Most cortical bone loss occurs by intracortical, not endocortical remodelling. Each remodelling event removes more bone than deposited enlarging existing canals which eventually coalesce eroding and thinning the cortex from 'within.' Thus, there is a need to study the decay of cortical as well as trabecular bone, and to develop drugs that restore the strength of both types of bone. It is now possible to accurately quantify cortical porosity and trabecular decay in vivo. The challenges still to be met are to determine whether measurement of porosity identifies persons at risk for fracture, whether this approach is compliments information obtained using bone densitometry, and whether changes in cortical porosity and other microstructural traits have the sensitivity to serve as surrogates of treatment success or failure.

Citations

Citations to this article as recorded by  
  • Differences in bone accrual over one year in young girls with obesity compared to Normal weight controls
    Vibha Singhal, Snimarjot Kaur, Lea Abou Haidar, Hang Lee, Miriam A. Bredella, Madhusmita Misra
    Bone.2023; 172: 116757.     CrossRef
  • The age-related characteristics in bone microarchitecture, osteoclast distribution pattern, functional and transcriptomic alterations of BMSCs in mice
    QianKun Yang, ZhiYuan Wei, XiaoYu Wei, Jie Zhang, Yong Tang, Xiang Zhou, Pan Liu, Ce Dou, Fei Luo
    Mechanisms of Ageing and Development.2023; 216: 111877.     CrossRef
  • Bilateral asymmetry of bone density adjacent to pelvic sarcomas: A retrospective study using computed tomography
    Andrew J. Baines, Ata Babazadeh‐Naseri, Nicholas J. Dunbar, Valerae O. Lewis, Benjamin J. Fregly
    Journal of Orthopaedic Research.2022; 40(3): 644.     CrossRef
  • The effect of short-term high-caloric feeding and fasting on bone microarchitecture
    Miriam A. Bredella, Pouneh K. Fazeli, Jenna Bourassa, Clifford J. Rosen, Mary L. Bouxsein, Anne Klibanski, Karen K. Miller
    Bone.2022; 154: 116214.     CrossRef
  • Image-based radiodensity profilometry measures early remodeling at the bone-callus interface in sheep
    Tianyi Ren, Karina Klein, Brigitte von Rechenberg, Salim Darwiche, Hannah L. Dailey
    Biomechanics and Modeling in Mechanobiology.2022; 21(2): 615.     CrossRef
  • The action of oxytocin on the bone of senescent female rats
    Luís Fernando Gadioli Santos, Fernanda Fernandes-Breitenbach, Rafael Augusto Santos Silva, Damáris Raíssa Santos, Melise Jacon Peres-Ueno, Edilson Ervolino, Antonio Hernandes Chaves-Neto, Rita Cássia Menegati Dornelles
    Life Sciences.2022; 297: 120484.     CrossRef
  • Cortical bone material / compositional properties in growing children and young adults aged 1.5–23 years, as a function of gender, age, metabolic activity, and growth spurt
    S. Gamsjaeger, F. Rauch, F.H. Glorieux, E.P. Paschalis
    Bone.2022; 165: 116548.     CrossRef
  • Age‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population
    Fan Yu, Yuping Xu, Yanfang Hou, Yuanyuan Lin, Ruizhi Jiajue, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Li Zhang, Ling Qin, Evelyn Hsieh, Weibo Xia
    Journal of Bone and Mineral Research.2020; 35(11): 2159.     CrossRef
  • Suboptimal bone microarchitecure in adolescent girls with obesity compared to normal-weight controls and girls with anorexia nervosa
    Vibha Singhal, Smriti Sanchita, Sonali Malhotra, Amita Bose, Landy Paola Torre Flores, Ruben Valera, Fatima Cody Stanford, Meghan Slattery, Jennifer Rosenblum, Mark A. Goldstein, Melanie Schorr, Kathryn E. Ackerman, Karen K. Miller, Anne Klibanski, Miriam
    Bone.2019; 122: 246.     CrossRef
  • Paget’s Disease of Long Bones: Microstructural Analyses of Historical Bone Samples
    Elena Nebot, Patrick Heimel, Stefan Tangl, Martin Dockner, Janina Patsch, Gerhard W. Weber, Michael Pretterklieber, Maria Teschler-Nicola, Peter Pietschmann
    Calcified Tissue International.2019; 105(1): 15.     CrossRef
  • Adding Marrow Adiposity and Cortical Porosity to Femoral Neck Areal Bone Mineral Density Improves the Discrimination of Women With Nonvertebral Fractures From Controls
    Roger Zebaze, Marit Osima, Minh Bui, Marko Lukic, Xiaofang Wang, Ali Ghasem-Zadeh, Erik F Eriksen, Angela Vais, Catherine Shore-Lorenti, Peter R Ebeling, Ego Seeman, Åshild Bjørnerem
    Journal of Bone and Mineral Research.2019; 34(8): 1451.     CrossRef
  • Assessing Cortical Thickness in Human Tibiae With Sonography vs Computed Tomography: A Pilot Study
    Sundus H. Mohammad, Randee L. Hunter, Rachel L. Tatarski, Angela N. Butwin, Kevin D. Evans
    Journal of Diagnostic Medical Sonography.2018; 34(3): 170.     CrossRef
  • Understanding age-induced cortical porosity in women: Is a negative BMU balance in quiescent osteons a major contributor?
    Christina M. Andreasen, Jean-Marie Delaisse, Bram C.J. van der Eerden, Johannes P.T.M. van Leeuwen, Ming Ding, Thomas L. Andersen
    Bone.2018; 117: 70.     CrossRef
  • Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone
    Lydia P Bakalova, Christina M Andreasen, Jesper Skovhus Thomsen, Annemarie Brüel, Ellen-Margrethe Hauge, Birgitte Jul Kiil, Jean-Marie Delaisse, Thomas Levin Andersen, Mariana E Kersh
    Journal of Bone and Mineral Research.2018; 33(12): 2177.     CrossRef
  • Diversity in intracortical remodeling in the human femoral bone: A novel view point with the morphological analysis of secondary osteons
    Junichiro Maeda, Kazunobu Saiki, Hisayoshi Kondo, Hiroaki Matsuo, Takeshi Imamura, Keiko Ogami-Takamura, Keishi Okamoto, Masato Tomita, Makoto Osaki, Toshiyuki Tsurumoto
    Journal of Orthopaedic Science.2018; 23(6): 1079.     CrossRef
  • Women with fracture, unidentified by FRAX, but identified by cortical porosity, have a set of characteristics that contribute to their increased fracture risk beyond high FRAX score and high cortical porosity
    Rita Kral, Marit Osima, Roald Vestgaard, Elin Richardsen, Åshild Bjørnerem
    Bone.2018; 116: 259.     CrossRef
  • Response to “Clinical Evaluation of Bone Strength and Fracture Risk”
    Anne B. Loucks, Brian C. Clark, Lyn Bowman
    Current Osteoporosis Reports.2017; 15(4): 396.     CrossRef
  • Ovarian hormone depletion affects cortical bone quality differently on different skeletal envelopes
    E.P. Paschalis, S. Gamsjaeger, N. Hassler, K. Klaushofer, D. Burr
    Bone.2017; 95: 55.     CrossRef
  • Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
    Cristina de Mello-Sampayo, Alaíde Alves Agripino, Duarte Stilwell, Bruno Vidal, Ana Luisa Fernando, Beatriz Silva-Lima, Maria Fátima Vaz, Helena Canhão, M. Cristina Marques
    International Journal of Endocrinology.2017; 2017: 1.     CrossRef
  • The Association of Higher Plasma Macrophage Migration Inhibitory Factor Levels with Lower Bone Mineral Density and Higher Bone Turnover Rate in Postmenopausal Women
    Hyeonmok Kim, Seong Hee Ahn, Chaeho Shin, Seung Hun Lee, Beom-Jun Kim, Jung-Min Koh
    Endocrinology and Metabolism.2016; 31(3): 454.     CrossRef
  • Intraskeletal variation in human cortical osteocyte lacunar density: Implications for bone quality assessment
    Randee L. Hunter, Amanda M. Agnew
    Bone Reports.2016; 5: 252.     CrossRef
  • The Bindex®ultrasound device: reliability of cortical bone thickness measures and their relationship to regional bone mineral density
    Martin Behrens, Sabine Felser, Anett Mau-Moeller, Matthias Weippert, Johannes Pollex, Ralf Skripitz, Philipp K E Herlyn, Dagmar-C Fischer, Sven Bruhn, Hans-Christof Schober, Volker Zschorlich, Thomas Mittlmeier
    Physiological Measurement.2016; 37(9): 1528.     CrossRef
Close layer
Bone Metabolism
Emerging Therapies for Osteoporosis
Michael R. McClung
Endocrinol Metab. 2015;30(4):429-435.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.429
  • 4,131 View
  • 45 Download
  • 23 Web of Science
  • 21 Crossref
AbstractAbstract PDFPubReader   

Although several effective therapies are available for the treatment of osteoporosis in postmenopausal women and older men, there remains a need for the development of even more effective and acceptable drugs. Several new drugs that are in late-stage clinical development will be discussed. Abaloparatide (recombinant parathyroid hormone related peptide [PTHrP] analogue) has anabolic activity like teriparatide. Recent data from the phase 3 fracture prevention trial demonstrate that this agent is effective in reducing fracture risk. Inhibiting cathepsin K reduces bone resorption without decreasing the numbers or activity of osteoclasts, thereby preserving or promoting osteoblast function. Progressive increases in bone mineral density (BMD) have been observed over 5 years. Early data suggest that odanacatib effectively reduces fracture risk. Lastly, inhibiting sclerostin with humanized antibodies promotes rapid, substantial but transient increases in bone formation while inhibiting bone resorption. Marked increases in BMD have been observed in phase 2 studies. Fracture prevention studies are underway. The new therapies with novel and unique mechanisms of action may, alone or in combination, provide more effective treatment options for our patients.

Citations

Citations to this article as recorded by  
  • The osteocyte as a signaling cell
    Jesus Delgado-Calle, Teresita Bellido
    Physiological Reviews.2022; 102(1): 379.     CrossRef
  • Combining sclerostin neutralization with tissue engineering: An improved strategy for craniofacial bone repair
    Sophie Maillard, Ludovic Sicard, Caroline Andrique, Coralie Torrens, Julie Lesieur, Brigitte Baroukh, Thibaud Coradin, Anne Poliard, Lotfi Slimani, Catherine Chaussain
    Acta Biomaterialia.2022; 140: 178.     CrossRef
  • Effects of sclerostin antibody on bone healing
    Atsushi Mihara, Kiminori Yukata, Toshihiro Seki, Ryuta Iwanaga, Norihiro Nishida, Kenzo Fujii, Yuji Nagao, Takashi Sakai
    World Journal of Orthopedics.2021; 12(9): 651.     CrossRef
  • Combining Sclerostin Neutralization with Tissue Engineering:  An Improved Strategy for Craniofacial Bone Repair
    Sophie Maillard, Ludovic Sicard, Caroline Andrique, Coralie Torrens, Julie Lesieur, Brigitte Baroukh, Thibaud Coradin, Anne Poliard, Lotfi Slimani, Catherine Chaussain
    SSRN Electronic Journal.2021;[Epub]     CrossRef
  • Potential Biomarkers to Improve the Prediction of Osteoporotic Fractures
    Beom-Jun Kim, Seung Hun Lee, Jung-Min Koh
    Endocrinology and Metabolism.2020; 35(1): 55.     CrossRef
  • Clinical Application of Teriparatide in Fracture Prevention
    Yuehong Chen, Ronghan Liu, Aubryanna Hettinghouse, Shuya Wang, Gang Liu, Chuan-ju Liu
    JBJS Reviews.2019; 7(1): e10.     CrossRef
  • The Emerging Role of Osteocytes in Cancer in Bone
    Emily G Atkinson, Jesús Delgado‐Calle
    JBMR Plus.2019;[Epub]     CrossRef
  • Osteoporosis therapies might lead to intervertebral disc degeneration via affecting cartilage endplate
    Zhen Sun, Zhuo-Jing Luo
    Medical Hypotheses.2019; 125: 5.     CrossRef
  • Polymersome nanoparticles for delivery of Wnt-activating small molecules
    Edoardo Scarpa, Agnieszka A Janeczek, Alethia Hailes, Maria C de Andrés, Antonio De Grazia, Richard OC Oreffo, Tracey A Newman, Nicholas D Evans
    Nanomedicine: Nanotechnology, Biology and Medicine.2018; 14(4): 1267.     CrossRef
  • Dual roles of QOA-8a in antiosteoporosis: a combination of bone anabolic and anti-resorptive effects
    Jing Wu, Qi Shen, Wei Cui, Yu Zhao, Yue Huai, Yu-chao Zhang, Bei-hua Bao, Chen-xi Liu, Qing Jiang, Jian-xin Li
    Acta Pharmacologica Sinica.2018; 39(2): 230.     CrossRef
  • Abaloparatide: Recombinant human PTHrP (1–34) anabolic therapy for osteoporosis
    Chee Kian Chew, Bart L. Clarke
    Maturitas.2017; 97: 53.     CrossRef
  • Dried and free flowing granules of Spinacia oleracea accelerate bone regeneration and alleviate postmenopausal osteoporosis
    Sulekha Adhikary, Dharmendra Choudhary, Naseer Ahmad, Sudhir Kumar, Kapil Dev, Naresh Mittapelly, Gitu Pandey, Prabhat Ranjan Mishra, Rakesh Maurya, Ritu Trivedi
    Menopause.2017; 24(6): 686.     CrossRef
  • Romosozumab for the treatment of osteoporosis
    Leonardo Bandeira, E. Michael Lewiecki, John P. Bilezikian
    Expert Opinion on Biological Therapy.2017; 17(2): 255.     CrossRef
  • The quest for new drugs to prevent osteoporosis-related fractures
    T. J. de Villiers
    Climacteric.2017; 20(2): 103.     CrossRef
  • Role and mechanism of action of sclerostin in bone
    Jesus Delgado-Calle, Amy Y. Sato, Teresita Bellido
    Bone.2017; 96: 29.     CrossRef
  • Biochemical Testing Relevant to Bone
    Chee Kian Chew, Bart L. Clarke
    Endocrinology and Metabolism Clinics of North America.2017; 46(3): 649.     CrossRef
  • Re-Invigorating the Osteoporosis Message
    Michael R. McClung
    Endocrine Practice.2016; 22(9): 1130.     CrossRef
  • Pharmacodynamics and pharmacokinetics of oral salmon calcitonin in the treatment of osteoporosis
    Leonardo Bandeira, E. Michael Lewiecki, John P. Bilezikian
    Expert Opinion on Drug Metabolism & Toxicology.2016; 12(6): 681.     CrossRef
  • Osteoporosis treatment: bisphosphonates reign to continue for a few more years, at least?
    Michael Pazianas, Bo Abrahamsen
    Annals of the New York Academy of Sciences.2016; 1376(1): 5.     CrossRef
  • Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts
    Julia Platas, Maria Isabel Guillén, Francisco Gomar, Miguel Angel Castejón, Pedro Esbrit, Maria José Alcaraz
    The Journals of Gerontology Series A: Biological Sciences and Medical Sciences.2016; : glw100.     CrossRef
  • Osteocytic signalling pathways as therapeutic targets for bone fragility
    Lilian I. Plotkin, Teresita Bellido
    Nature Reviews Endocrinology.2016; 12(10): 593.     CrossRef
Close layer
Adrenal gland
Hypoparathyroidism: Replacement Therapy with Parathyroid Hormone
Lars Rejnmark, Line Underbjerg, Tanja Sikjaer
Endocrinol Metab. 2015;30(4):436-442.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.436
  • 3,308 View
  • 36 Download
  • 11 Web of Science
  • 11 Crossref
AbstractAbstract PDFPubReader   

Hypoparathyroidism (HypoPT) is characterized by low serum calcium levels caused by an insufficient secretion of parathyroid hormone (PTH). Despite normalization of serum calcium levels by treatment with activated vitamin D analogues and calcium supplementation, patients are suffering from impaired quality of life (QoL) and are at increased risk of a number of comorbidities. Thus, despite normalization of calcium levels in response to conventional therapy, this should only be considered as an apparent normalization, as patients are suffering from a number of complications and calcium-phosphate homeostasis is not normalized in a physiological manner. In a number of recent studies, replacement therapy with recombinant human PTH (rhPTH(1-84)) as well as therapy with the N-terminal PTH fragment (rhPTH(1-34)) have been investigated. Both drugs have been shown to normalize serum calcium while reducing needs for activated vitamin D and calcium supplements. However, once a day injections cause large fluctuations in serum calcium. Twice a day injections diminish fluctuations, but don't restore the normal physiology of calcium homeostasis. Recent studies using pump-delivery have shown promising results on maintaining normocalcemia with minimal fluctuations in calcium levels. Further studies are needed to determine whether this may improve QoL and lower risk of complications. Such data are needed before replacement with the missing hormone can be recommended as standard therapy.

Citations

Citations to this article as recorded by  
  • Point-of-Care Peptide Hormone Production Enabled by Cell-Free Protein Synthesis
    Madison A. DeWinter, Ariel Helms Thames, Laura Guerrero, Weston Kightlinger, Ashty S. Karim, Michael C. Jewett
    ACS Synthetic Biology.2023; 12(4): 1216.     CrossRef
  • Comparing laser speckle contrast imaging and indocyanine green angiography for assessment of parathyroid perfusion
    Emmanuel A. Mannoh, Naira Baregamian, Giju Thomas, Carmen C. Solόrzano, Anita Mahadevan-Jansen
    Scientific Reports.2023;[Epub]     CrossRef
  • Effects of Multi-stage Procurement on the Viability and Function of Human Donor Parathyroid Glands
    Yvonne M. Kelly, Casey Ward, Run Zhang, Shareef Syed, Peter G. Stock, Quan-Yang Duh, Julie A. Sosa, James Koh
    Journal of Surgical Research.2022; 276: 404.     CrossRef
  • Kidney Complications and Hospitalization in Patients With Chronic Hypoparathyroidism: A Cohort Study in Sweden
    Oskar Swartling, Marie Evans, Tim Spelman, Wafa Kamal, Olle Kämpe, Michael Mannstadt, Ylva Trolle Lagerros, Sigridur Björnsdottir
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(10): e4098.     CrossRef
  • Hypocalcaemia
    Zaki Hassan-Smith, Neil Gittoes
    Medicine.2021; 49(9): 562.     CrossRef
  • Safety and Efficacy of 5 Years of Treatment With Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism
    Michael Mannstadt, Bart L Clarke, John P Bilezikian, Henry Bone, Douglas Denham, Michael A Levine, Munro Peacock, Jeffrey Rothman, Dolores M Shoback, Mark L Warren, Nelson B Watts, Hak-Myung Lee, Nicole Sherry, Tamara J Vokes
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(11): 5136.     CrossRef
  • Management of Endocrine Emergencies in the ICU
    Judith Jacobi
    Journal of Pharmacy Practice.2019; 32(3): 314.     CrossRef
  • Microencapsulated parathyroid allotransplantation in the omental tissue
    Emrah Yucesan, Harun Basoglu, Beyza Goncu, Fahri Akbas, Yeliz Emine Ersoy, Erhan Aysan
    Artificial Organs.2019; 43(10): 1022.     CrossRef
  • Die HypAus-Studie
    Maximilian Zach, Adelina Tmava-Berisha, Stefan Schatzl, Michael Lehner, Greisa Vila, Karin Amrein
    Journal für Klinische Endokrinologie und Stoffwechsel.2018; 11(2): 45.     CrossRef
  • Sustained release of parathyroid hormone via in situ cross‐linking gelatin hydrogels improves the therapeutic potential of tonsil‐derived mesenchymal stem cells for hypoparathyroidism
    Yoon Shin Park, Yunki Lee, Yoon Mi Jin, Gyungah Kim, Sung Chul Jung, Yoon Jeong Park, Ki Dong Park, Inho Jo
    Journal of Tissue Engineering and Regenerative Medicine.2018;[Epub]     CrossRef
  • Hypocalcaemia
    Zaki Hassan-Smith, Neil Gittoes
    Medicine.2017; 45(9): 555.     CrossRef
Close layer
Adrenal gland
Diagnosis and Treatment of Hypopituitarism
Seong Yeon Kim
Endocrinol Metab. 2015;30(4):443-455.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.443
  • 12,504 View
  • 364 Download
  • 47 Web of Science
  • 58 Crossref
AbstractAbstract PDFPubReader   

Hypopituitarism is a chronic endocrine illness that caused by varied etiologies. Clinical manifestations of hypopituitarism are variable, often insidious in onset and dependent on the degree and severity of hormone deficiency. However, it is associated with increased mortality and morbidity. Therefore, early diagnosis and prompt treatment is necessary. Hypopituitarism can be easily diagnosed by measuring basal pituitary and target hormone levels except growth hormone (GH) and adrenocorticotropic hormone (ACTH) deficiency. Dynamic stimulation tests are indicated in equivocal basal hormone levels and GH/ACTH deficiency. Knowledge of the use and limitations of these stimulation tests is mandatory for proper interpretation. It is necessary for physicians to inform their patients that they may require lifetime treatment. Hormone replacement therapy should be individualized according to the specific needs of each patient, taking into account possible interactions. Long-term endocrinological follow-up of hypopituitary patients is important to monitor hormonal replacement regimes and avoid under- or overtreatment.

Citations

Citations to this article as recorded by  
  • Pituitary stem cells: past, present and future perspectives
    María Inés Pérez Millán, Leonard Y. M. Cheung, Florencia Mercogliano, Maria Andrea Camilletti, Gonzalo T. Chirino Felker, Lucia N. Moro, Santiago Miriuka, Michelle L. Brinkmeier, Sally A. Camper
    Nature Reviews Endocrinology.2024; 20(2): 77.     CrossRef
  • Idiopathic isolated adrenocorticotropic hormone deficiency: a systematic review of a heterogeneous and underreported disease
    E. Van Mieghem, C. De Block, C. De Herdt
    Pituitary.2024; 27(1): 23.     CrossRef
  • A comprehensive review of the new FIGO classification of ovulatory disorders
    Adam H Balen, Jennifer Tamblyn, Karolina Skorupskaite, Malcolm G Munro
    Human Reproduction Update.2024;[Epub]     CrossRef
  • Decreased mannan-binding lectin level in adults with hypopituitarism; dependence on appropriate hormone replacement therapies
    Aleksandra E. Matusiak, Jan Stępniak, Andrzej Lewiński, Małgorzata Karbownik-Lewińska
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Post-Operative Medium- and Long-Term Endocrine Outcomes in Patients with Non-Functioning Pituitary Adenomas—Machine Learning Analysis
    Ziad Hussein, Robert W. Slack, Hani J. Marcus, Evangelos B. Mazomenos, Stephanie E. Baldeweg
    Cancers.2023; 15(10): 2771.     CrossRef
  • Central Endocrine Complications Among Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review
    Greg Wheeler, Clemens Grassberger, Josephine Samers, Mary Dwyer, Kirsty Wiltshire, Patricia Daly, Beatriz Alvarez, Belinda A. Campbell, Amanda J. Kerr, Tomas Kron, Frances K. Duane, Margaret Zacharin, Peter Downie, Elizabeth Kyriakou, Cecile M. Ronckers,
    International Journal of Radiation Oncology*Biology*Physics.2023;[Epub]     CrossRef
  • The TRH test provides valuable information in the diagnosis of central hypothyroidism in patients with known pituitary disease and low T4 levels
    Sara Ellegaard Christensen, Liv Norma Smith, Christian Alexander H. Rosendal, Helga Angela Gulisano, Kåre Schmidt Ettrup, Peter Vestergaard, Eigil Husted Nielsen, Jesper Scott Karmisholt, Jakob Dal
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Sheehan’s syndrome unveiled after decades without a diagnosis: A case report
    Hadi Rabee’, Tamara Braik, Rezeq Alnatour, Alaa Shamlawi, Ammar Rashed
    SAGE Open Medical Case Reports.2023;[Epub]     CrossRef
  • PAN-HIPOPITUITARISMO SECUNDÁRIO A INFECÇÃO POR SARS-COV-2: RELATO DE CASO
    Rosyane Luz Rufino De Lima, Viviane dos Reis Vieira Yance
    REVISTA FOCO.2023; 16(12): e3832.     CrossRef
  • Perioperative growth hormone levels as an early predictor of new-onset secondary adrenal insufficiency following transsphenoidal pituitary tumor resection
    Fon-Yih Tsuang, Shyang-Rong Shih, Ham-Min Tseng, Huan-Chih Wang
    Asian Journal of Surgery.2023;[Epub]     CrossRef
  • Navigating the “specific etiology” steatohepatitis category: Evaluation and management of nonalcoholic/nonmetabolic dysfunction–associated steatohepatitis
    Mohammad Qasim Khan, Sara Hassan, Blanca C. Lizaola-Mayo, Mamatha Bhat, Kymberly D. Watt
    Hepatology.2023;[Epub]     CrossRef
  • Regulation of the Hypothalamic-Pituitary-Testicular Axis: Pathophysiology of Hypogonadism
    Aditi Sharma, Channa N. Jayasena, Waljit S. Dhillo
    Endocrinology and Metabolism Clinics of North America.2022; 51(1): 29.     CrossRef
  • Penetrating brain injury with hypopituitarism
    Rachel D. Appelbaum, Kristina E. Neri, Kristin A. Rebo, Samuel P. Carmichael
    Trauma Case Reports.2022; 38: 100628.     CrossRef
  • Risk of Mental Illnesses in Patients With Hypopituitarism: A Nationwide Population-Based Cohort Study
    I-Hua Wei, Chih-Chia Huang
    Psychiatry Investigation.2022; 19(6): 418.     CrossRef
  • Pituitary Apoplexy and Subdural Hematoma after Caesarean Section
    Van Trung Hoang, The Huan Hoang, Thanh Tam Thi Nguyen, Vichit Chansomphou, Duc Thanh Hoang, Kyousuke Takeuchi
    Case Reports in Obstetrics and Gynecology.2022; 2022: 1.     CrossRef
  • A Unique Case Mimicking Sepsis
    Vivek Dave, Anish Joshi
    Journal of Acute Care.2022; 1(1): 29.     CrossRef
  • Correlation between shift work and non-alcoholic fatty liver disease among male workers in the steel manufacturing company of Korea: a cross-sectional study
    Kiseok Kim, Yong-Jin Lee, Soon-Chan Kwon, Young-Sun Min, Hyun Kyo Lee, Gwangin Baek, Sang Hyeon Kim, Eun-Chul Jang
    Annals of Occupational and Environmental Medicine.2022;[Epub]     CrossRef
  • Non-alcoholic fatty liver disease across endocrinopathies: Interaction with sex hormones
    Sara Arefhosseini, Mehrangiz Ebrahimi-Mameghani, Farzad Najafipour, Helda Tutunchi
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Primary hypothyroidism and postmenopause as the causes of delayed diagnosis of panhypopituitarism in a patient with nonfunctional pituitary adenoma
    E. G. Ryzhkova, D. O. Ladygina
    Problems of Endocrinology.2022; 68(5): 32.     CrossRef
  • Efficacy and Safety of Stereotactic Radiotherapy in Cushing’s Disease: A Single Center Experience
    Tugce Apaydin, Hande Mefkure Ozkaya, Sebnem Memis Durmaz, Rasim Meral, Pinar Kadioglu
    Experimental and Clinical Endocrinology & Diabetes.2021; 129(07): 482.     CrossRef
  • Metabolic and Endocrine Challenges
    Gennaro Martucci, Eleonora Bonicolini, Dhruv Parekh, Onn Shaun Thein, Mario Scherkl, Karin Amrein
    Seminars in Respiratory and Critical Care Medicine.2021; 42(01): 078.     CrossRef
  • The Effect of Pituitary Gland Disorders on Glucose Metabolism: From Pathophysiology to Management
    Guy I. Sydney, Konstantinos Michalakis, Ilias P. Nikas, Eleftherios Spartalis, Stavroula A. Paschou
    Hormone and Metabolic Research.2021; 53(01): 16.     CrossRef
  • Congenital hypopituitarism in two brothers with a duplication of the ‘acrogigantism gene’ GPR101: clinical findings and review of the literature
    Melitza S. M. Elizabeth, Annemieke J. M. H. Verkerk, Anita C. S. Hokken-Koelega, Joost A. M. Verlouw, Jesús Argente, Roland Pfaeffle, Sebastian J. C. M. M. Neggers, Jenny A. Visser, Laura C. G. de Graaff
    Pituitary.2021; 24(2): 229.     CrossRef
  • Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications
    Ana-Maria Singeap, Carol Stanciu, Laura Huiban, Cristina Maria Muzica, Tudor Cuciureanu, Irina Girleanu, Stefan Chiriac, Sebastian Zenovia, Robert Nastasa, Catalin Sfarti, Camelia Cojocariu, Anca Trifan, Branka Filipović
    Canadian Journal of Gastroenterology and Hepatology.2021; 2021: 1.     CrossRef
  • The evaluation of pituitary damage associated with cardiac arrest: An experimental rodent model
    Yu Okuma, Tomoaki Aoki, Santiago J. Miyara, Kei Hayashida, Mitsuaki Nishikimi, Ryosuke Takegawa, Tai Yin, Junhwan Kim, Lance B. Becker, Koichiro Shinozaki
    Scientific Reports.2021;[Epub]     CrossRef
  • Functional Restoration of Pituitary after Pituitary Allotransplantation into Hypophysectomized Rats
    Jai Ho Choi, Jung Eun Lee, Hong-Lim Kim, Seung Hyun Ko, Se Hoon Kim, Seung Ho Yang
    Cells.2021; 10(2): 267.     CrossRef
  • Experience of a Pituitary Clinic for US Military Veterans With Traumatic Brain Injury
    Jonathan Lee, Lindsey J Anderson, Dorota Migula, Kevin C J Yuen, Lisa McPeak, Jose M Garcia
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • Biogenic zinc-oxide nanoparticles of Moringa oleifera leaves abrogates rotenone induced neuroendocrine toxicity by regulation of oxidative stress and acetylcholinesterase activity
    J.K. Akintunde, T.I. Farai, M.R. Arogundade, J.T. Adeleke
    Biochemistry and Biophysics Reports.2021; 26: 100999.     CrossRef
  • Heart Rate Variability in Postoperative Patients with Nonfunctioning Pituitary Adenoma
    Jeonghoon Ha, Hansang Baek, Chaiho Jeong, Minsoo Yeo, Seung-Hwan Lee, Jae Hyoung Cho, Ki-Hyun Baek, Moo Il Kang, Dong-Jun Lim
    Endocrinology and Metabolism.2021; 36(3): 678.     CrossRef
  • Aetiologies and clinical patterns of hypopituitarism in Sudanese children
    Samar Hassan, Renson Mukhwana, Salwa Musa, Areej Ibrahim, Omer Babiker, Mohamed Abdullah
    Sudanese Journal of Paediatrics.2021; : 53.     CrossRef
  • Recent advances in proteomics and its implications in pituitary endocrine disorders
    Arghya Banerjee, Atul Goel, Abhidha Shah, Sanjeeva Srivastava
    Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.2021; 1869(11): 140700.     CrossRef
  • Morning Serum Cortisol as a Predictor for the HPA Axis Recovery in Cushing’s Disease
    Q. Cui, D. Liu, B. Xiang, Q. Sun, L. Fan, M. He, Y. Wang, X. Zhu, H. Ye, Giorgio Borretta
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • Three different faces of TACI mutations
    Sukru Cekic, Fatih Cicek, Yasin Karali, Orhan Gorukmez, Erdal Eren, Sara Sebnem Kilic
    Scandinavian Journal of Immunology.2020;[Epub]     CrossRef
  • Treatment of a Woman with Inoperable Meningioma Using Mifepristone for 26 Years
    Maria das Dores Medina-Lopes, Luiz Augusto Casulari
    Case Reports in Neurological Medicine.2020; 2020: 1.     CrossRef
  • Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology
    Jung Hee Kim, Hyun Wook Chae, Sang Ouk Chin, Cheol Ryong Ku, Kyeong Hye Park, Dong Jun Lim, Kwang Joon Kim, Jung Soo Lim, Gyuri Kim, Yun Mi Choi, Seong Hee Ahn, Min Ji Jeon, Yul Hwangbo, Ju Hee Lee, Bu Kyung Kim, Yong Jun Choi, Kyung Ae Lee, Seong-Su Moon
    Endocrinology and Metabolism.2020; 35(2): 272.     CrossRef
  • Phenytoin- Medication That Warrants Deviation From Standard Approach for Thyroid Lab Interpretation
    Vishwanath Pattan, Narsimha Candula, Ramesh Adhikari, Rahul Kashyap
    Cureus.2020;[Epub]     CrossRef
  • Pituitary Disorders in Pregnancy
    Whitney W. Woodmansee
    Neurologic Clinics.2019; 37(1): 63.     CrossRef
  • A clinical case of partial hypopituitarism
    T. E. Pomytkina
    Fundamental and Clinical Medicine.2019; 4(3): 122.     CrossRef
  • Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function
    Tatiana Danilova, Emilia Galli, Emmi Pakarinen, Erik Palm, Päivi Lindholm, Mart Saarma, Maria Lindahl
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Functional survival of rat pituitary gland in hypothermic storage for pituitary transplantation
    Jai Ho Choi, Jung Eun Lee, Se Hoon Kim, Hong-Lim Kim, Sin Soo Jeun, Seung Ho Yang
    Pituitary.2019; 22(4): 353.     CrossRef
  • Fertility after transsphenoidal surgery in patients with prolactinomas: A meta-analysis
    Nayan Lamba, Nadia Noormohamed, Thomas Simjian, Mona Y. Alsheikh, Alykhan Jamal, Joanne Doucette, Hasan Zaidi, Timothy R. Smith, Rania A. Mekary
    Clinical Neurology and Neurosurgery.2019; 176: 53.     CrossRef
  • Traumatic brain injury and hypopituitarism
    Sarah Leeder
    Advances in Clinical Neuroscience & Rehabilitation.2019;[Epub]     CrossRef
  • Long-acting FC-fusion rhGH (GX-H9) shows potential for up to twice-monthly administration in GH-deficient adults
    Cheol Ryong Ku, Thierry Brue, Katharina Schilbach, Stanislav Ignatenko, Sandor Magony, Yoon-Sok Chung, Byung-Joon Kim, Kyu Yeon Hur, Ho-Cheol Kang, Jung Hee Kim, Min Seon Kim, Aldona Kowalska, Marek Bolanowski, Marek Ruchala, Svetozar Damjanovic, Juraj Pa
    European Journal of Endocrinology.2018; 179(3): 169.     CrossRef
  • Prolactinomas Resistant to Treatment With Dopamine Agonists: Long-Term Follow-Up of Six Cases
    Maria de Fátima de Magalhães Gonzaga, Lucas Faria de Castro, Luciana Ansaneli Naves, José Luiz Mendonça, Benicio Oton de Lima, Iruena Kessler, Luiz Augusto Casulari
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Oxytocin and Naltrexone Successfully Treat Hypothalamic Obesity in a Boy Post-Craniopharyngioma Resection
    Eugenie A Hsu, Jennifer L Miller, Francisco A Perez, Christian L Roth
    The Journal of Clinical Endocrinology & Metabolism.2018; 103(2): 370.     CrossRef
  • Spectrum of Sellar and Parasellar Region Lesions: A retrospective study from Basrah, Iraq
    Abbas Ali Mansour, Ali Hussain Ali Alhamza, Ammar Mohammed Saeed Abdullah Almomin, Ibrahim Abbood Zaboon, Nassar Taha Yaseen Alibrahim, Rudha Naser Hussein, Muayad Baheer Kadhim, Haider Ayad Yassin Alidrisi, Hussein Ali Nwayyir, Adel Gassab Mohammed, Dhey
    F1000Research.2018; 7: 430.     CrossRef
  • Delayed Complications After Transsphenoidal Surgery for Pituitary Adenomas
    Gmaan Alzhrani, Walavan Sivakumar, Min S. Park, Philipp Taussky, William T. Couldwell
    World Neurosurgery.2018; 109: 233.     CrossRef
  • Hypopituitarism: Case Study Involving Hypernatremia Prompting Discovery of a Pituitary Disorder in a Patient With Lymphoma
    Jace Johnny
    Clinical Journal of Oncology Nursing.2018; 22(4): E115.     CrossRef
  • Reflex and reflective testing strategies for early detection of pituitary dysfunction
    Manal Elnenaei, Derek Minney, David B. Clarke, Andrew Kumar-Misir, Syed Ali Imran
    Clinical Biochemistry.2018; 54: 78.     CrossRef
  • Clinical Parameters to Distinguish Silent Corticotroph Adenomas from Other Nonfunctioning Pituitary Adenomas
    Daham Kim, Cheol Ryong Ku, Se Hee Park, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Eun Jig Lee
    World Neurosurgery.2018; 115: e464.     CrossRef
  • The Incidence of Anterior Pituitary Hormone Deficiencies in Patients with Pituitary Microadenoma and Idiopathic Hyperprolactinaemia. A Retrospective Single Centre Study

    Journal of Clinical Review & Case Reports.2018;[Epub]     CrossRef
  • Spectrum of Pituitary disorders: A retrospective study from Basrah, Iraq
    Abbas Ali Mansour, Ali Hussain Ali Alhamza, Ammar Mohammed Saeed Abdullah Almomin, Ibrahim Abbood Zaboon, Nassar Taha Yaseen Alibrahim, Rudha Naser Hussein, Muayad Baheer Kadhim, Haider Ayad Yassin Alidrisi, Hussein Ali Nwayyir, Adel Gassab Mohammed, Dhey
    F1000Research.2018; 7: 430.     CrossRef
  • Growth Hormone & Hypopituitarism
    Lahiry  Sandeep
    Journal of Analytical & Pharmaceutical Research.2017;[Epub]     CrossRef
  • Using the Complexity of Hypopituitarism Aetiology to Understand and Teach Hormone Function in Endocrinology
    Ayisha Qureshi
    MOJ Anatomy & Physiology.2017;[Epub]     CrossRef
  • Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency
    Kyung Mi Jang, Cheol Woo Ko
    Annals of Pediatric Endocrinology & Metabolism.2017; 22(3): 208.     CrossRef
  • Indicaciones e interpretación diagnóstica de las pruebas funcionales hipofisarias
    C. Tasende Fernández, M.J. Rodríguez Troyano, D.S. Trifu, P. Gómez Montes
    Medicine - Programa de Formación Médica Continuada Acreditado.2016; 12(15): 865.     CrossRef
  • Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic–pituitary–gonadal, hypothalamic–pituitary–thyroid and hypothalamic–pituitary–adrenal axes dysfunction
    L. Curtò, F. Trimarchi
    Journal of Endocrinological Investigation.2016; 39(10): 1115.     CrossRef
  • Hipopituitarismo. Panhipopituitarismo
    N. Peláez Torres, D.S. Trifu, M.P Gómez Montes, E. Atienza Sánchez
    Medicine - Programa de Formación Médica Continuada Acreditado.2016; 12(15): 857.     CrossRef
Close layer
Adrenal gland
Congenital Hypogonadotropic Hypogonadism and Kallmann Syndrome: Past, Present, and Future
Soo-Hyun Kim
Endocrinol Metab. 2015;30(4):456-466.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.456
  • 7,402 View
  • 112 Download
  • 68 Web of Science
  • 65 Crossref
AbstractAbstract PDFPubReader   

The proper development and coordination of the hypothalamic-pituitary-gonadal (HPG) axis are essential for normal reproductive competence. The key factor that regulates the function of the HPG axis is gonadotrophin-releasing hormone (GnRH). Timely release of GnRH is critical for the onset of puberty and subsequent sexual maturation. Misregulation in this system can result in delayed or absent puberty and infertility. Congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS) are genetic disorders that are rooted in a GnRH deficiency but often accompanied by a variety of non-reproductive phenotypes such as the loss of the sense of smell and defects of the skeleton, eye, ear, kidney, and heart. Recent progress in DNA sequencing technology has produced a wealth of information regarding the genetic makeup of CHH and KS patients and revealed the resilient yet complex nature of the human reproductive neuroendocrine system. Further research on the molecular basis of the disease and the diverse signal pathways involved will aid in improving the diagnosis, treatment, and management of CHH and KS patients as well as in developing more precise genetic screening and counseling regime.

Citations

Citations to this article as recorded by  
  • In vitro modeling of cranial placode differentiation: Recent advances, challenges, and perspectives
    Casey Griffin, Jean-Pierre Saint-Jeannet
    Developmental Biology.2024; 506: 20.     CrossRef
  • Effects of Exercise on Testosterone and Implications of Drug Abuse: A Review
    Brendan Perreault, Nikki Hammond, Panayotis K. Thanos
    Clinical Neuropharmacology.2023; 46(3): 112.     CrossRef
  • A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism
    Xinying Wang, Danna Chen, Yaguang Zhao, Meichao Men, Zhiheng Chen, Fang Jiang, Ruizhi Zheng, Maria I Stamou, Lacey Plummer, Ravikumar Balasubramanian, Jia-Da Li
    Human Molecular Genetics.2023; 32(10): 1722.     CrossRef
  • RNF216 affects the stability of STAU2 in the hypothalamus
    Han Yang, Yong Zhu, Xin Li, Zuiming Jiang, Wenting Dai
    Development, Growth & Differentiation.2023; 65(7): 408.     CrossRef
  • Etiology of Male Infertility: an Update
    Indrashis Bhattacharya, Souvik Sen Sharma, Subeer S. Majumdar
    Reproductive Sciences.2023;[Epub]     CrossRef
  • Two Sisters with Kallmann Syndrome, Gonadal Dysgenesis, and Multiple Neuromuscular and Endocrine Disorders: Report of Two Cases with Description of an Unusual Association
    Marta Camacho, Camil Castelo-Branco
    Reproductive Sciences.2022; 29(10): 2859.     CrossRef
  • A Molecular Analysis of Neural Olfactory Placode Differentiation in Human Pluripotent Stem Cells
    Rebecca L. Bricker, Uchit Bhaskar, Rossella Titone, Melanie A. Carless, Tiziano Barberi
    Stem Cells and Development.2022; 31(17-18): 507.     CrossRef
  • The use of stimulation tests for the differential diagnosis of delayed puberty in boys. How to increase the specificity of the method?
    Irina Yu. Ioffe, Yulia L. Skorodok, Elena V. Plotnikova, Irena I. Nagornaya, Ksenia O. Nagovitsyna, Lyudmila A. Jelenina
    Pediatrician (St. Petersburg).2022; 13(3): 15.     CrossRef
  • The diagnostic value of the olfactory evaluation for congenital hypogonadotropic hypogonadism
    Bingqing Yu, Kepu Chen, Jiangfeng Mao, Bo Hou, Hui You, Xi Wang, Min Nie, Qibin Huang, Rui Zhang, Yiyi Zhu, Bang Sun, Feng Feng, Wen Zhou, Xueyan Wu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Genetic analysis of failed male puberty using whole exome sequencing
    Maleeha Akram, David J. Handelsman, Mazhar Qayyum, Marina Kennerson, Sania Rauf, Shahid Ahmed, Osama Ishtiaq, Muhammad Ismail, Qaisar Mansoor, Afzaal Ahmed Naseem, Syed Shakeel Raza Rizvi
    Journal of Pediatric Endocrinology and Metabolism.2022; 35(11): 1410.     CrossRef
  • Genetics of congenital olfactory dysfunction: a systematic review of the literature
    Matthias Deller, Janine Gellrich, Elisabeth C Lohrer, Valentin A Schriever
    Chemical Senses.2022;[Epub]     CrossRef
  • Testicular ultrasound in a patient with Kallmann syndrome: A case report
    Daniela Donat, Sonja Lukac, Ivana Bajkin, Ivana Vorgucin, Viktor Till, Sladjana Zagorac
    Medicinski pregled.2022; 75(7-8): 247.     CrossRef
  • Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism
    Meichao Men, Xinying Wang, Jiayu Wu, Wang Zeng, Fang Jiang, Ruizhi Zheng, Jia-Da Li
    Journal of Medical Genetics.2021; 58(1): 66.     CrossRef
  • Conditional Fgfr1 Deletion in GnRH Neurons Leads to Minor Disruptions in the Reproductive Axis of Male and Female Mice
    Cynthia Dela Cruz, Cassandra A. Horton, Kelsey N. Sanders, Nathan D. Andersen, Pei-San Tsai
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • A case report of congenital idiopathic hypogonadotropic hypogonadism caused by novel mutation of GNRHR gene
    Liping Wang, Weisheng Lin, Xiaohong Li, Lijuan Zhang, Kai Wang, Xiaoli Cui, Shanmei Tang, Guangguang Fang, Yan Tan, Xuelai Wang, Chuan Chen, Chuanchun Yang, Huiru Tang
    Medicine.2021; 100(5): e24007.     CrossRef
  • RNF216 regulates meiosis and PKA stability in the testes
    Dengfeng Li, Fangfang Li, Lanlan Meng, Huafang Wei, Qianjun Zhang, Fang Jiang, Dan‐Na Chen, Wei Li, Yue‐Qiu Tan, Jia‐Da Li
    The FASEB Journal.2021;[Epub]     CrossRef
  • Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease
    Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Masataka Sata
    The Journal of Medical Investigation.2021; 68(1.2): 189.     CrossRef
  • The Differential Roles for Neurodevelopmental and Neuroendocrine Genes in Shaping GnRH Neuron Physiology and Deficiency
    Roberto Oleari, Valentina Massa, Anna Cariboni, Antonella Lettieri
    International Journal of Molecular Sciences.2021; 22(17): 9425.     CrossRef
  • Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism
    Meichao Men, Dan‐Na Chen, Jia‐Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng, Wenting Dai
    Molecular Genetics & Genomic Medicine.2021;[Epub]     CrossRef
  • A Novel SEMA3G Mutation in Two Siblings Affected by Syndromic GnRH Deficiency
    Roberto Oleari, Valentina André, Antonella Lettieri, Sophia Tahir, Lise Roth, Alyssa Paganoni, Ivano Eberini, Chiara Parravicini, Valeria Scagliotti, Ludovica Cotellessa, Francesco Bedogni, Lisa Benedetta De Martini, Maria Vittoria Corridori, Simona Gulli
    Neuroendocrinology.2021; 111(5): 421.     CrossRef
  • A novel heterozygous intron mutation in SEMA7A causing kallmann syndrome in a female
    Yongting Zhao, Fan Yang, Lili Qiu, Lihong Wang, Hui Che
    Gynecological Endocrinology.2020; 36(3): 218.     CrossRef
  • Phenotypic Spectrum of Idiopathic Hypogonadotropic Hypogonadism Patients With CHD7 Variants From a Large Chinese Cohort
    Jia-Da Li, Jiayu Wu, Yaguang Zhao, Xinying Wang, Fang Jiang, Qiao Hou, Dan-Na Chen, Ruizhi Zheng, Renhe Yu, Wei Zhou, Meichao Men
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(5): 1515.     CrossRef
  • Genotypic and phenotypic spectra of FGFR1, FGF8, and FGF17 mutations in a Chinese cohort with idiopathic hypogonadotropic hypogonadism
    Meichao Men, Jiayu Wu, Yaguang Zhao, Xiaoliang Xing, Fang Jiang, Ruizhi Zheng, Jia-Da Li
    Fertility and Sterility.2020; 113(1): 158.     CrossRef
  • Posttranslational Modification Defects in Fibroblast Growth Factor Receptor 1 as a Reason for Normosmic Isolated Hypogonadotropic Hypogonadism
    Hui Ying, Yan Sun, Huixiao Wu, Wenyu Jia, Qingbo Guan, Zhao He, Ling Gao, Jiajun Zhao, Yiming Ji, Guimei Li, Chao Xu, Fabio Altieri
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • CHD7 missense variants and clinical characteristics of Chinese males with infertility
    Leilei Li, Ruixue Wang, Yang Yu, Hongguo Zhang, Yuting Jiang, Xiao Yang, Ruizhi Liu
    Molecular Genetics & Genomic Medicine.2020;[Epub]     CrossRef
  • Lifestyle, metabolic disorders and male hypogonadism – A one-way ticket?
    Luís Crisóstomo, Sara C. Pereira, Mariana P. Monteiro, João F. Raposo, Pedro F. Oliveira, Marco G. Alves
    Molecular and Cellular Endocrinology.2020; 516: 110945.     CrossRef
  • GnRH Deficient Patients With Congenital Hypogonadotropic Hypogonadism: Novel Genetic Findings in ANOS1, RNF216, WDR11, FGFR1, CHD7, and POLR3A Genes in a Case Series and Review of the Literature
    Vassos Neocleous, Pavlos Fanis, Meropi Toumba, George A. Tanteles, Melpo Schiza, Feride Cinarli, Nicolas C. Nicolaides, Anastasis Oulas, George M. Spyrou, Christos S. Mantzoros, Dimitrios Vlachakis, Nicos Skordis, Leonidas A. Phylactou
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Eje hipotálamo hipofisario. Fisiología y patología
    M. Araujo-Castro, E. Pascual-Corrales, A.E. Ortiz-Flores, H.F. Escobar-Morreale
    Medicine - Programa de Formación Médica Continuada Acreditado.2020; 13(15): 846.     CrossRef
  • WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System
    Yeonjoo Kim, Soo-Hyun Kim
    Endocrinology and Metabolism.2020; 35(3): 494.     CrossRef
  • Eight rare urinary disorders in a patient with Kallmann syndrome
    Huining Tian, Zi Yan, You Lv, Lin Sun, Xiaokun Gang, Guixia Wang
    Medicine.2020; 99(43): e22936.     CrossRef
  • Delayed and Precocious Puberty: Genetic Underpinnings and Treatments
    Anisha Gohil, Erica A. Eugster
    Endocrinology and Metabolism Clinics of North America.2020; 49(4): 741.     CrossRef
  • Disorders of Sex Development: Classification, Review, and Impact on Fertility
    Pedro Acién, Maribel Acién
    Journal of Clinical Medicine.2020; 9(11): 3555.     CrossRef
  • A nonsense variant in FGFR1: a rare cause of combined pituitary hormone deficiency
    İbrahim Mert Erbaş, Ahu Paketçi, Sezer Acar, Leman Damla Kotan, Korcan Demir, Ayhan Abacı, Ece Böber
    Journal of Pediatric Endocrinology and Metabolism.2020; 33(12): 1613.     CrossRef
  • Kallman syndrome and central non-obstructive azoospermia
    Sameer Thakker, Jesse Persily, Bobby B. Najari
    Best Practice & Research Clinical Endocrinology & Metabolism.2020; 34(6): 101475.     CrossRef
  • RNF216 Regulates the Migration of Immortalized GnRH Neurons by Suppressing Beclin1-Mediated Autophagy
    Fangfang Li, Dengfeng Li, Huadie Liu, Bei-Bei Cao, Fang Jiang, Dan-Na Chen, Jia-Da Li
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Parallel Multi-Gene Panel Testing for Diagnosis of Idiopathic Hypogonadotropic Hypogonadism/Kallmann Syndrome
    Manickavasagam Senthilraja, Aaron Chapla, Felix K. Jebasingh, Dukhabhandhu Naik, Thomas V. Paul, Nihal Thomas
    Case Reports in Genetics.2019; 2019: 1.     CrossRef
  • Screening for mutations in selected miRNA genes in hypogonadotropic hypogonadism patients
    Anna-Pauliina Iivonen, Johanna Känsäkoski, Kirsi Vaaralahti, Taneli Raivio
    Endocrine Connections.2019; 8(5): 506.     CrossRef
  • Live birth in male de novo Kallmann syndrome after cross-generational genetic sequencing
    Cindy Chan, Cheng-Wei Wang, Ching-Hui Chen, Chi-Huang Chen
    Journal of Assisted Reproduction and Genetics.2019; 36(12): 2481.     CrossRef
  • Is Hormonal Treatment of Congenital Undescended Testes Justified A Debate
    Faruk Hadziselimovic
    Sexual Development.2019; 13(1): 3.     CrossRef
  • High frequency of CHD7 mutations in congenital hypogonadotropic hypogonadism
    Catarina Inês Gonçalves, Filipa Marina Patriarca, José Maria Aragüés, Davide Carvalho, Fernando Fonseca, Sofia Martins, Olinda Marques, Bernardo Dias Pereira, José Martinez-de-Oliveira, Manuel Carlos Lemos
    Scientific Reports.2019;[Epub]     CrossRef
  • PROKR2mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to aGα‐protein leads to biased signaling
    Yaguang Zhao, Jiayu Wu, Hong Jia, Xinying Wang, Ruizhi Zheng, Fang Jiang, Dan-Na Chen, Zhiheng Chen, Jia-Da Li
    The FASEB Journal.2019; 33(3): 4538.     CrossRef
  • Congenital diaphragmatic hernia is associated with nonscrotal testes
    Stan Janssen, Kim Heiwegen, Iris ALM van Rooij, Janielle van Alfen-van der Velden, Ivo de Blaauw, Sanne MBI Botden
    Journal of Pediatric Surgery.2019; 54(3): 445.     CrossRef
  • Cranial Pair 0: The Nervus Terminalis
    Ángel Peña‐Melián, Juan Pablo Cabello‐de la Rosa, Maria José Gallardo‐Alcañiz, Julia Vaamonde‐Gamo, Fernanda Relea‐Calatayud, Lucía González‐López, Patricia Villanueva‐Anguita, Alicia Flores‐Cuadrado, Daniel Saiz‐Sánchez, Alino Martínez‐Marcos
    The Anatomical Record.2019; 302(3): 394.     CrossRef
  • Semaphorin Signaling in GnRH Neurons: From Development to Disease
    Roberto Oleari, Antonella Lettieri, Alyssa Paganoni, Luca Zanieri, Anna Cariboni
    Neuroendocrinology.2019; 109(3): 193.     CrossRef
  • Whole Exome Sequencing Revealed a Novel Nonsense Variant in the GNRHR Gene Causing Normosmic Hypogonadotropic Hypogonadism in a Pakistani Family
    Hafiz Muhammad Jafar Hussain, Ghulam Murtaza, Xiaohua Jiang, Ranjha Khan, Manan Khan, Mian Basit Shah Kakakhel, Teka Khan, Fazal Wahab, Huan Zhang, Yuanwei Zhang, Muhammad Bilal Khan, Parvez Ahmed, Hui Ma, Zhipeng Xu
    Hormone Research in Paediatrics.2019; 91(1): 9.     CrossRef
  • New intronic Fibroblast Growth Factor Receptor 1 (FGFR1) mutation leading to disrupted splicing and Kallmann syndrome
    J Känsäkoski, K Vaaralahti, T Raivio
    Human Reproduction.2018; 33(2): 328.     CrossRef
  • Rare cause of manic period trigger in bipolar mood disorder: testosterone replacement
    Gulcin Elboga, Zeynel Abidin Sayiner
    BMJ Case Reports.2018; : bcr-2018-225108.     CrossRef
  • WDR11‐mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
    Yeon‐Joo Kim, Daniel PS Osborn, Ji‐Young Lee, Masatake Araki, Kimi Araki, Timothy Mohun, Johanna Känsäkoski, Nina Brandstack, Hyun‐Taek Kim, Francesc Miralles, Cheol‐Hee Kim, Nigel A Brown, Hyung‐Goo Kim, Juan Pedro Martinez‐Barbera, Paris Ataliotis, Tane
    EMBO reports.2018; 19(2): 269.     CrossRef
  • A rare ANOS1 variant in siblings with Kallmann syndrome identified by whole exome sequencing
    D. M. Lopategui, A. J. Griswold, H. Arora, R. I. Clavijo, M. Tekin, R. Ramasamy
    Andrology.2018; 6(1): 53.     CrossRef
  • Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
    L M Huckins, K Hatzikotoulas, L Southam, L M Thornton, J Steinberg, F Aguilera-McKay, J Treasure, U Schmidt, C Gunasinghe, A Romero, C Curtis, D Rhodes, J Moens, G Kalsi, D Dempster, R Leung, A Keohane, R Burghardt, S Ehrlich, J Hebebrand, A Hinney, A Lud
    Molecular Psychiatry.2018; 23(5): 1169.     CrossRef
  • The hypothalamus-pituitary-gonad axis: Tales of mice and men
    Athina Kaprara, Ilpo T. Huhtaniemi
    Metabolism.2018; 86: 3.     CrossRef
  • Assisted reproductive techniques with congenital hypogonadotropic hypogonadism patients: a systematic review and meta-analysis
    Yinjie Gao, Bingqing Yu, Jiangfeng Mao, Xi Wang, Min Nie, Xueyan Wu
    BMC Endocrine Disorders.2018;[Epub]     CrossRef
  • A novel PNPLA6 compound heterozygous mutation identified in a Chinese patient with Boucher‑Neuh�user syndrome
    Ruizhi Zheng, Yaguang Zhao, Jiayu Wu, Yuanmei Wang, Jian‑Ling Liu, Zhi‑Ling Zhou, Xiao‑Tao Zhou, Dan‑Na Chen, Wei‑Hua Liao, Jia‑Da Li
    Molecular Medicine Reports.2018;[Epub]     CrossRef
  • A dominant negative FGFR1 mutation identified in a Kallmann syndrome patient
    Hunjin Luo, Ruizhi Zheng, Yaguang Zhao, Jiayu Wu, Jie Li, Fang Jiang, Dan-Na Chen, Xiao-Tao Zhou, Jia-Da Li
    Gene.2017; 621: 1.     CrossRef
  • Characterization of an X-chromosomal non-mosaic monosomy (59, X0) dairy heifer detected using routinely available single nucleotide polymorphism genotype data1
    D. P. Berry, A. Wolfe, J. O'Donovan, N. Byrne, R. G. Sayers, K. G. Dodds, J. C. McEwan, R. E. O'Connor, M. McClure, D. C. Purfield
    Journal of Animal Science.2017; 95(3): 1042.     CrossRef
  • Genetic basis of eugonadal and hypogonadal female reproductive disorders
    Tatiana Trofimova, Daria Lizneva, Larisa Suturina, Walidah Walker, Yen-Hao Chen, Ricardo Azziz, Lawrence C. Layman
    Best Practice & Research Clinical Obstetrics & Gynaecology.2017; 44: 3.     CrossRef
  • Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility
    Kashan Ahmed, Mary P. LaPierre, Emanuel Gasser, Rémy Denzler, Yinjie Yang, Thomas Rülicke, Jukka Kero, Mathieu Latreille, Markus Stoffel
    Journal of Clinical Investigation.2017; 127(3): 1061.     CrossRef
  • Next-generation sequencing of patients with congenital anosmia
    Anna Alkelai, Tsviya Olender, Catherine Dode, Sagit Shushan, Pavel Tatarskyy, Edna Furman-Haran, Valery Boyko, Ruth Gross-Isseroff, Matthew Halvorsen, Lior Greenbaum, Roni Milgrom, Kazuya Yamada, Ayumi Haneishi, Ilan Blau, Doron Lancet
    European Journal of Human Genetics.2017; 25(12): 1377.     CrossRef
  • Analysis of genetic and clinical characteristics of a Chinese Kallmann syndrome cohort with ANOS1 mutations
    Min Nie, Hongli Xu, Rongrong Chen, Jiangfeng Mao, Xi Wang, Shuyu Xiong, Junjie Zheng, Bingqing Yu, Mingxuan Cui, Wanlu Ma, Qibin Huang, Hongbing Zhang, Xueyan Wu
    European Journal of Endocrinology.2017; 177(4): 389.     CrossRef
  • Kallmann syndrome in pediatric otorhinolaryngology practice – Case report and literature review
    Karolina Dżaman, Karolina Zborowska – Piskadło, Mirosława Pietniczka – Załęska, Ireneusz Kantor
    International Journal of Pediatric Otorhinolaryngology.2017; 100: 149.     CrossRef
  • A heterozygous microdeletion of 20p12.2–3 encompassing PROKR2 and BMP2 in a patient with congenital hypopituitarism and growth hormone deficiency
    Samuel J. H. Parsons, Neville B. Wright, Emma Burkitt‐Wright, Mars S. Skae, Phillip G. Murray
    American Journal of Medical Genetics Part A.2017; 173(8): 2261.     CrossRef
  • Arachnoid cyst: a further anomaly associated with Kallmann syndrome?
    Luca Massimi, Alessandro Izzo, Giovanna Paternoster, Paolo Frassanito, Concezio Di Rocco
    Child's Nervous System.2016; 32(9): 1607.     CrossRef
  • What do we learn from the murineJacob/Nsmfgene knockout for human disease?
    Christina Spilker, Katarzyna M. Grochowska, Michael R. Kreutz
    Rare Diseases.2016; 4(1): e1241361.     CrossRef
  • Sexuality and quality of life in congenital hypogonadisms
    María Fernanda Garrido Oyarzún, Camil Castelo-Branco
    Gynecological Endocrinology.2016; 32(12): 947.     CrossRef
  • Gene Expression Changes Underlying Idiopathic Central Hypogonadism in Cryptorchidism with Defective Mini-Puberty
    Faruk Hadziselimovic, Katharina Gegenschatz-Schmid, Gilvydas Verkauskas, Maria J. Docampo-Garcia, Philippe Demougin, Vytautas Bilius, Dalius Malcius, Darius Dasevicius, Michael B. Stadtler
    Sexual Development.2016; 10(3): 136.     CrossRef
Close layer
Editorial
Obesity and Metabolism
Sulfonylurea: Personalized Medicine for Type 2 Diabetes
You-Cheol Hwang
Endocrinol Metab. 2015;30(4):467-468.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.467
  • 2,634 View
  • 35 Download
PDFPubReader   
Close layer
Original Articles
Clinical Study
Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population
Yong Joo Hong, Eun Seok Kang, Myoung Jin Ji, Hyung Jin Choi, Taekeun Oh, Sung-Soo Koong, Hyun Jeong Jeon
Endocrinol Metab. 2015;30(4):469-474.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.469
  • 3,935 View
  • 45 Download
  • 23 Web of Science
  • 22 Crossref
AbstractAbstract PDFPubReader   
Background

Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is related with calcification and lipolysis, insulin secretion, and may be associated with many complicated disease including diabetes and cardiovascular disease. Recent studies reported that single nucleotide polymorphisms of vitamin D receptor (VDR) gene were associated with diabetic complications.

Methods

In present study, we evaluated the association of BsmI polymorphism of VDR with diabetic complications in Korean diabetes patients. Total of 537 type 2 diabetic subjects from the Endocrinology Clinic of Chungbuk National University Hospital were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to test the genotype and allele frequency of BsmI (rs1544410; BB, Bb, bb) polymorphisms.

Results

Mean age was 62.44±10.64 years and mean disease duration was 13.65±7.39 years. Patients with B allele (BB or Bb) was significantly associated with lower risk of diabetic retinopathy (severe non-proliferative diabetic retinopathy or proliferative retinopathy; 7.4%, 5/68) compared with patients without B allele (bb; 17.3%, 81/469; P=0.035). This association was also significant after adjusting for hemoglobin A1c level, body mass index, age, sex, and diabetes mellitus duration, concurrent dyslipidemia and hypertension (odds ratio, 2.99; 95% confidence interval, 1.08 to 8.29; P=0.035) in logistic regression analysis.

Conclusion

Our findings suggest that B allele of Bsm1 polymorphism in VDR gene is associated with lower risk of diabetic retinopathy in type 2 diabetic patients. Bsm1 genotype could be used as a susceptibility marker to predict the risk of diabetes complication.

Citations

Citations to this article as recorded by  
  • The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism
    Serkan YILDIZ, Serbülent YİĞİT, Ayşe Feyda NURSAL, Nevin KARAKUŞ, Mehmet Kemal TÜMER
    ADO Klinik Bilimler Dergisi.2024; 13(1): 100.     CrossRef
  • Association analysis between the VDR gene variants and type 2 diabetes
    Shabnam Salehizadeh, Sara Ramezani, Mojgan Asadi, Mahdi Afshari, Seyed Hamid Jamaldini, Farhad Adhami Moghadam, Mandana Hasanzad
    Journal of Diabetes & Metabolic Disorders.2023;[Epub]     CrossRef
  • Metabolic impact of the VDR rs1544410 in diabetic retinopathy
    Caroline Severo de Assis, Tainá Gomes Diniz, João Otávio Scarano Alcântara, Vanessa Polyana Alves de Sousa Brito, Rayner Anderson Ferreira do Nascimento, Mayara Karla dos Santos Nunes, Alexandre Sérgio Silva, Isabella Wanderley de Queiroga Evangelista, Ma
    PLOS ONE.2022; 17(2): e0263346.     CrossRef
  • Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases
    Miłosz Caban, Urszula Lewandowska
    Nutrients.2022; 14(11): 2353.     CrossRef
  • Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease
    Paula González Rojo, Cristina Pérez Ramírez, José María Gálvez Navas, Laura Elena Pineda Lancheros, Susana Rojo Tolosa, María del Carmen Ramírez Tortosa, Alberto Jiménez Morales
    International Journal of Molecular Sciences.2022; 23(15): 8686.     CrossRef
  • Effects of Vitamin D Receptor Genotype on Lipid Profiles and Retinopathy Risk in Type 2 Diabetes Patients: A Pilot Study
    Hussam Alhawari, Yazun Jarrar, Dina Abulebdah, Sara J. Abaalkhail, Marah Alkhalili, Sura Alkhalili, Hussein Alhawari, Munther Momani, Mohammed N. Obeidat, Rand K. Fram, Mohammad A. Salahat, Su-Jun Lee
    Journal of Personalized Medicine.2022; 12(9): 1488.     CrossRef
  • Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population
    S. Yildiz, M.K. Tumer, S. Yigit, A.F. Nursal, A. Rustemoglu, Y. Balel
    British Journal of Oral and Maxillofacial Surgery.2021; 59(5): 555.     CrossRef
  • The relationship between vitamin D receptor (VDR) rs2228570 and rs7975232 genetic variants and the risk of recurrent pregnancy loss
    Zohreh Salari, Nasrollah Saleh-Gohari, Monire Rezapour, Ahamad Khosravi, Hadi Tavakkoli, Ehsan Salarkia, Fatemeh Karami-Robati
    Meta Gene.2021; 27: 100833.     CrossRef
  • Association of Bone Metabolism Indices and Bone Mineral Density with Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Inpatient Study in China
    Xin Zhao, Lili Huo, Xiaofeng Yu, Xiaomei Zhang, Fabio Vescini
    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
  • The Associations Between Vitamin D Receptor BsmI and ApaI Polymorphisms and Obesity in Korean Patients with Type 2 Diabetes Mellitus
    Sang Won Nam, Jinwoo Choi, Hyun Jeong Jeon, Tae Keun Oh, Dong-Hwa Lee
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 557.     CrossRef
  • Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
    Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
    Endocrinology and Metabolism.2020; 35(1): 97.     CrossRef
  • The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review
    Maria Grammatiki, Spiros Karras, Kalliopi Kotsa
    Hormones.2019; 18(1): 37.     CrossRef
  • Vitamin D-binding protein and vitamin D receptor genotypes and 25-hydroxyvitamin D levels are associated with development of aortic and mitral valve calcification and coronary artery diseases
    Amir Kiani, Ehsan Mohamadi-Nori, Asad Vaisi-Raygani, Maryam Tanhapour, Said Elahi-Rad, Fariborz Bahrehmand, Zohreh Rahimi, Tayebeh Pourmotabbed
    Molecular Biology Reports.2019; 46(5): 5225.     CrossRef
  • Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies
    Shamaila Rafiq, Per Jeppesen
    Nutrients.2018; 10(1): 59.     CrossRef
  • Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: A meta‐analysis
    Fang Yin, Jing Liu, Ming‐Xiu Fan, Xiao‐Li Zhou, Xiao‐Ling Zhang
    Nephrology.2018; 23(2): 107.     CrossRef
  • BSMI single nucleotide polymorphism in vitamin D receptor gene is associated with decreased circulatory levels of serum 25-hydroxyvitamin D among micro and macrovascular complications of type 2 diabetes mellitus
    Krishnamoorthy Ezhilarasi, Umapathy Dhamodharan, Viswanathan Vijay
    International Journal of Biological Macromolecules.2018; 116: 346.     CrossRef
  • Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy
    Suzanne Broadgate, Christine Kiire, Stephanie Halford, Victor Chong
    Acta Ophthalmologica.2018; 96(A111): 1.     CrossRef
  • Expression of JAZF1, ABCC8, KCNJ11and Notch2 genes and vitamin D receptor polymorphisms in type 2 diabetes, and their association with microvascular complications
    Maha A. Rasheed, Nagwa Kantoush, Nagwa Abd El-Ghaffar, Hebatallah Farouk, Solaf Kamel, Alshaymaa Ahmed Ibrahim, Aliaa Shalaby, Eman Mahmoud, Hala M. Raslan, Omneya M. Saleh
    Therapeutic Advances in Endocrinology and Metabolism.2017; 8(6): 97.     CrossRef
  • Vitamin D and diabetes mellitus: Causal or casual association?
    M. Grammatiki, E. Rapti, S. Karras, R. A. Ajjan, Kalliopi Kotsa
    Reviews in Endocrine and Metabolic Disorders.2017; 18(2): 227.     CrossRef
  • The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies
    Bang-An Luo, Fan Gao, Lu-Lu Qin
    Nutrients.2017; 9(3): 307.     CrossRef
  • The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
    Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
    BioMed Research International.2016; 2016: 1.     CrossRef
  • Candidate gene studies of diabetic retinopathy in human
    Petra Priščáková, Gabriel Minárik, Vanda Repiská
    Molecular Biology Reports.2016; 43(12): 1327.     CrossRef
Close layer
Clinical Study
Characteristics of Korean Patients with Antithyroid Drug-Induced Agranulocytosis: A Multicenter Study in Korea
Hee Kyung Kim, Jee Hee Yoon, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Min Jin Lee, Bo Hyun Kim, In Joo Kim, Ji Young Joung, Sun Wook Kim, Jae Hoon Chung, Ho-Cheol Kang
Endocrinol Metab. 2015;30(4):475-480.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.475
  • 4,024 View
  • 56 Download
  • 16 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   
Background

Antithyroid drugs (ATDs) can lead to the development of agranulocytosis, which is the most serious adverse effect. Characteristics of ATD-induced agranulocytosis (AIA) have seldom been reported due to the rarity. In this study, we characterized the clinical features for AIA in Korean patients.

Methods

We retrospectively reviewed data from patients with AIA diagnosed between 1997 and 2014 at four tertiary hospitals. Agranulocytosis was defined as an absolute neutrophil count (ANC) below 500/mm3.

Results

The mean age of the patients (11 males, 43 females) was 38.2±14.9 years. Forty-eight patients (88.9%) with AIA had fever and sore throat on initial presentation, 20.4% of patients developed AIA during the second course of treatment, and 75.9% of patients suffered AIA within 3 months after initiation of ATD. The patients taking methimazole (n=39) showed lower levels of ANC and more frequent use of granulocyte-macrophage colony-stimulating factor than propylthiouracil (n=15) users. The median duration of agranulocytosis was 5.5 days (range, 1 to 20). No differences were observed between the long (≥6 days) and short recovery time (≤5 days) groups in terms of age, gender, ATDs, duration of ATDs, or initial ANC levels. Four patients (7.4%) who were taking ATDs for less than 2 months died of sepsis on the first or second day of hospitalization.

Conclusion

The majority of AIA incidents occur in the early treatment period. Considering the high fatality rate of AIA, an early aggressive therapeutic approach is critical and patients should be well informed regarding the warning symptoms of the disease.

Citations

Citations to this article as recorded by  
  • Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis
    Yayi He, Pan Ma, Yuanlin Luo, Xiaojuan Gong, Jiayang Gao, Yuxin Sun, Pu Chen, Suliang Zhang, Yuxin Tian, Bingyin Shi, Bao Zhang
    Experimental and Clinical Endocrinology & Diabetes.2024; 132(01): 17.     CrossRef
  • A Disproportionality Analysis of the Adverse Effect Profiles of Methimazole and Propylthiouracil in Patients with Hyperthyroidism Using the Japanese Adverse Drug Event Report Database
    Masanori Arai, Takahiro Tsuno, Hiromi Konishi, Kuniyuki Nishiyama, Yasuo Terauchi, Ryota Inoue, Jun Shirakawa
    Thyroid®.2023; 33(7): 804.     CrossRef
  • The Current Status of Hyperthyroidism in Korea
    Hyemi Kwon
    Endocrinology and Metabolism.2023; 38(4): 392.     CrossRef
  • Clinical characteristics of neutropenic patients under antithyroid drug: Twelve-year experience in a medical center
    Chih-Hsueh Tseng, Chi-Lung Tseng, Harn-Shen Chen, Pei-Lung Chen, Chun-Jui Huang
    Journal of the Chinese Medical Association.2023; 86(9): 826.     CrossRef
  • Association of MICA gene polymorphisms with thionamide-induced agranulocytosis
    P. Ma, P. Chen, J. Gao, H. Guo, S. Li, J. Yang, J. Lai, X. Yang, B. Zhang, Y. He
    Journal of Endocrinological Investigation.2021; 44(2): 363.     CrossRef
  • Efficacy and adverse events related to the initial dose of methimazole in children and adolescents with Graves’ disease
    Hyun Gyung Lee, Eun Mi Yang, Chan Jong Kim
    Annals of Pediatric Endocrinology & Metabolism.2021; 26(3): 199.     CrossRef
  • MICA polymorphisms associated with antithyroid drug‐induced agranulocytosis in the Chinese Han population
    Xiaojuan Gong, Pu Chen, Pan Ma, Jiayang Gao, Jingsi Yang, Hui Guo, Chunxia Yan, Bao Zhang, Yayi He
    Immunity, Inflammation and Disease.2020; 8(4): 695.     CrossRef
  • The Management of Thyroid Disease in COVID-19 Pandemic
    Won Sang Yoo, Hyun-Kyung Chung
    International Journal of Thyroidology.2020; 13(2): 65.     CrossRef
  • Increased Risk of Antithyroid Drug Agranulocytosis Associated with Amiodarone-Induced Thyrotoxicosis: A Population-Based Cohort Study
    Michal Gershinsky, Walid Saliba, Idit Lavi, Chen Shapira, Naomi Gronich
    Thyroid.2019; 29(2): 193.     CrossRef
  • A Case of Acute Supraglottitis Following Anti-Thyroid Drug-Induced Agranulocytosis
    Jung Jun Lee, Dong Young Kim, Jeon Yeob Jang
    Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics.2019; 30(2): 128.     CrossRef
  • Association of HLA-B∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients
    Mai Phuong Thao, Pham Vo Anh Tuan, Le Gia Hoang Linh, Lam Van Hoang, Phan Huu Hen, Le Tuyet Hoa, Hoang Anh Vu, Do Duc Minh
    International Journal of Endocrinology.2018; 2018: 1.     CrossRef
  • Severe Gingival Ulceration and Necrosis Caused by an Antithyroid Drug: One Case Report and Proposed Clinical Approach
    Ying‐Ying Chang, Chih‐Wen Tseng, Kuo Yuan
    Clinical Advances in Periodontics.2018; 8(1): 11.     CrossRef
  • Emphasis on the early diagnosis of antithyroid drug-induced agranulocytosis: retrospective analysis over 16 years at one Chinese center
    Y. He, J. Li, J. Zheng, Z. Khan, W. Qiang, F. Gao, Y. Zhao, B. Shi
    Journal of Endocrinological Investigation.2017; 40(7): 733.     CrossRef
  • Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China
    Yayi He, Jie Zheng, Qian Zhang, Peng Hou, Feng Zhu, Jian Yang, Wenhao Li, Pu Chen, Shu Liu, Bao Zhang, Bingyin Shi
    Scientific Reports.2017;[Epub]     CrossRef
  • Use of granulocyte colony‐stimulating factor in the treatment of methimazole‐induced agranulocytosis: a case report
    Asha Birmingham, Carissa Mancuso, Craig Williams
    Clinical Case Reports.2017; 5(10): 1701.     CrossRef
  • 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis
    Douglas S. Ross, Henry B. Burch, David S. Cooper, M. Carol Greenlee, Peter Laurberg, Ana Luiza Maia, Scott A. Rivkees, Mary Samuels, Julie Ann Sosa, Marius N. Stan, Martin A. Walter
    Thyroid.2016; 26(10): 1343.     CrossRef
Close layer
Clinical Study
A 5-Year Prospective Follow-Up Study of Lipid-Rich Adrenal Incidentalomas: No Tumor Growth or Development of Hormonal Hypersecretion
Camilla Schalin-Jäntti, Merja Raade, Esa Hämäläinen, Timo Sane
Endocrinol Metab. 2015;30(4):481-487.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.481
  • 3,416 View
  • 39 Download
  • 22 Web of Science
  • 22 Crossref
AbstractAbstract PDFPubReader   
Background

Current guidelines for follow-up of adrenal incidentalomas are extensive and hampered by lack of follow-up studies. We tested the hypothesis that small lipid-rich adrenal incidentalomas, initially characterized by tumor size <40 mm and <10 Hounsfield units (HUs) on unenhanced computed tomography (CT) may not demonstrate excessive growth/hormonal hypersecretion on follow-up.

Methods

Sixty-nine incidentalomas in 56 patients were restudied with unenhanced CT and screening for hypercortisolism (dexamethasone suppression test [DST], plasma adrenocorticotropic hormone) and pheochromocytoma (24-hour urinary metanephrines and normetanephrines) 5 years later. Primary hyperaldosteronism was excluded at base-line.

Results

Tumor (n=69) size was similar before and after 5 years follow-up (19±6 mm vs. 20±7 mm). Mean tumor growth was 1±2 mm. Largest increase in tumor size was 8 mm, this tumor was surgically removed and histopathology confirmed cortical adenoma. DST was normal in 54 patients and two patients (3.6%) were still characterized by subclinical hypercortisolism. Initial tumor size was >20 mm for the patient with largest tumor growth and those with subclinical hypercortisolism. All patients had normal 24-hour urinary metanephrines and normetanephrines. Low attenuation (<10 HU) was demonstrated in 97% of 67 masses re-evaluated with unenhanced CT.

Conclusion

None of the patients developed clinically relevant tumor growth or new subclinical hypercortisolism. Biochemical screening for pheochromocytoma in incidentalomas demonstrating <10 HU on unenhanced CT is not needed. For such incidentalomas <40 mm, it seems sufficient to perform control CT and screen for hypercortisolism after 5 years.

Citations

Citations to this article as recorded by  
  • European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors
    Martin Fassnacht, Stylianos Tsagarakis, Massimo Terzolo, Antoine Tabarin, Anju Sahdev, John Newell-Price, Iris Pelsma, Ljiljana Marina, Kerstin Lorenz, Irina Bancos, Wiebke Arlt, Olaf M Dekkers
    European Journal of Endocrinology.2023; 189(1): G1.     CrossRef
  • Diagnostic Accuracy of CT Texture Analysis in Adrenal Masses: A Systematic Review
    Filippo Crimì, Emilio Quaia, Giulio Cabrelle, Chiara Zanon, Alessia Pepe, Daniela Regazzo, Irene Tizianel, Carla Scaroni, Filippo Ceccato
    International Journal of Molecular Sciences.2022; 23(2): 637.     CrossRef
  • Susceptibility and characteristics of infections in patients with glucocorticoid excess or insufficiency: the ICARO tool
    Marianna Minnetti, Valeria Hasenmajer, Emilia Sbardella, Francesco Angelini, Chiara Simeoli, Nicola Di Paola, Alessia Cozzolino, Claudia Pivonello, Dario De Alcubierre, Sabrina Chiloiro, Roberto Baldelli, Laura De Marinis, Rosario Pivonello, Riccardo Pofi
    European Journal of Endocrinology.2022; 187(5): 719.     CrossRef
  • Approach to large adrenal tumors
    Urszula Ambroziak
    Current Opinion in Endocrinology, Diabetes & Obesity.2021; 28(3): 271.     CrossRef
  • Frequently asked questions and answers (if any) in patients with adrenal incidentaloma
    F. Ceccato, M. Barbot, C. Scaroni, M. Boscaro
    Journal of Endocrinological Investigation.2021; 44(12): 2749.     CrossRef
  • Draft of the clinical practice guidelines “Adrenal incidentaloma”
    D. G. Beltsevich, E. A. Troshina, G. A. Melnichenko, N. M. Platonova, D. O. Ladygina, A. Chevais
    Endocrine Surgery.2021; 15(1): 4.     CrossRef
  • Attenuation Value in Adrenal Incidentalomas: A Longitudinal Study
    Filippo Ceccato, Irene Tizianel, Giacomo Voltan, Gianmarco Maggetto, Isabella Merante Boschin, Emilio Quaia, Filippo Crimì, Carla Scaroni
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Guía práctica sobre la evaluación inicial, seguimiento y tratamiento de los incidentalomas adrenales. Grupo de patología adrenal de la Sociedad Española de Endocrinología y Nutrición
    Marta Araujo-Castro, Marta Iturregui Guevara, María Calatayud Gutiérrez, Paola Parra Ramírez, Paola Gracia Gimeno, Felicia Alexandra Hanzu, Cristina Lamas Oliveira
    Endocrinología, Diabetes y Nutrición.2020; 67(6): 408.     CrossRef
  • Practical guide on the initial evaluation, follow-up, and treatment of adrenal incidentalomas. Adrenal Diseases Group of the Spanish Society of Endocrinology and Nutrition
    Marta Araujo-Castro, Marta Iturregui Guevara, María Calatayud Gutiérrez, Paola Parra Ramírez, Paola Gracia Gimeno, Felicia Alexandra Hanzu, Cristina Lamas Oliveira
    Endocrinología, Diabetes y Nutrición (English ed.).2020; 67(6): 408.     CrossRef
  • Endocrine Causes of Hypertension
    Taniya de Silva, Gina Cosentino, Suneeta Ganji, Alejandra Riera-Gonzalez, Daniel S. Hsia
    Current Hypertension Reports.2020;[Epub]     CrossRef
  • Adrenocortical carcinoma: presentation and outcome of a contemporary patient series
    Iiro Kostiainen, Liisa Hakaste, Pekka Kejo, Helka Parviainen, Tiina Laine, Eliisa Löyttyniemi, Mirkka Pennanen, Johanna Arola, Caj Haglund, Ilkka Heiskanen, Camilla Schalin-Jäntti
    Endocrine.2019; 65(1): 166.     CrossRef
  • CT Characteristics of Pheochromocytoma: Relevance for the Evaluation of Adrenal Incidentaloma
    Letizia Canu, Janna A W Van Hemert, Michiel N Kerstens, Robert P Hartman, Aakanksha Khanna, Ivana Kraljevic, Darko Kastelan, Corin Badiu, Urszula Ambroziak, Antoine Tabarin, Magalie Haissaguerre, Edward Buitenwerf, Anneke Visser, Massimo Mannelli, Wiebke
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(2): 312.     CrossRef
  • The Evaluation of Incidentally Discovered Adrenal Masses
    Anand Vaidya, Amir Hamrahian, Irina Bancos, Maria Fleseriu, Hans K. Ghayee
    Endocrine Practice.2019; 25(2): 178.     CrossRef
  • Evaluation of quantitative parameters for distinguishing pheochromocytoma from other adrenal tumors
    Youichi Ohno, Masakatsu Sone, Daisuke Taura, Toshinari Yamasaki, Katsutoshi Kojima, Kyoko Honda-Kohmo, Yorihide Fukuda, Koji Matsuo, Toshihito Fujii, Akihiro Yasoda, Osamu Ogawa, Nobuya Inagaki
    Hypertension Research.2018; 41(3): 165.     CrossRef
  • Long term follow-up of non functional adrenal incidentalomas in size: a single center experience
    Güven Barış Cansu, Bengür Taşkıran, Eylem Bahadır
    Ortadoğu Tıp Dergisi.2018; 10(4): 506.     CrossRef
  • Unenhanced CT imaging is highly sensitive to exclude pheochromocytoma: a multicenter study
    Edward Buitenwerf, Tijmen Korteweg, Anneke Visser, Charlotte M S C Haag, Richard A Feelders, Henri J L M Timmers, Letizia Canu, Harm R Haak, Peter H L T Bisschop, Elisabeth M W Eekhoff, Eleonora P M Corssmit, Nanda C Krak, Elise Rasenberg, Janneke van den
    European Journal of Endocrinology.2018; 178(5): 431.     CrossRef
  • The impact of an adrenal incidentaloma algorithm on the evaluation of adrenal nodules
    Leslie S. Eldeiry, Marina M. Alfisher, Catherine F. Callahan, Nancy N. Hanna, Jeffrey R. Garber
    Journal of Clinical & Translational Endocrinology.2018; 13: 39.     CrossRef
  • Adrenal incidentaloma: differential diagnosis and management strategies
    Valentina Morelli, Serena Palmieri
    Minerva Endocrinologica.2018;[Epub]     CrossRef
  • Adrenal Imaging
    Mishal Mendiratta-Lala, Anca Avram, Adina F. Turcu, N. Reed Dunnick
    Endocrinology and Metabolism Clinics of North America.2017; 46(3): 741.     CrossRef
  • Update on the risks of benign adrenocortical incidentalomas
    Guido Di Dalmazi
    Current Opinion in Endocrinology, Diabetes & Obesity.2017; 24(3): 193.     CrossRef
  • Management Scheme for Adrenal Incidentalomas: Who Gets What?
    Glenda G. Callender, Robert Udelsman
    Current Surgery Reports.2016;[Epub]     CrossRef
  • Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors
    Martin Fassnacht, Wiebke Arlt, Irina Bancos, Henning Dralle, John Newell-Price, Anju Sahdev, Antoine Tabarin, Massimo Terzolo, Stylianos Tsagarakis, Olaf M Dekkers
    European Journal of Endocrinology.2016; 175(2): G1.     CrossRef
Close layer
Clinical Study
Subclinical Atherosclerosis in Patients with Cushing Syndrome: Evaluation with Carotid Intima-Media Thickness and Ankle-Brachial Index
Luigi Petramala, D'Elia Lorenzo, Gino Iannucci, Antonio Concistré, Laura Zinnamosca, Cristiano Marinelli, Giuseppe De Vincentis, Antonio Ciardi, Giorgio De Toma, Claudio Letizia
Endocrinol Metab. 2015;30(4):488-493.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.488
  • 3,510 View
  • 39 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   
Background

Cushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. In fact, chronic cortisol excess leads to a constellation of complications, including hypertension, hyperglycemia, adiposity, and thromboembolism. The main vascular alteration associated with CS is atherosclerosis.

Methods

Aim of this study was to analyze carotid intima-media thickness (cIMT) and ankle-brachial index (ABI), two surrogate markers of subclinical atherosclerosis in a consecutive series of CS patients, compared to patients with essential hypertension (EH) and health subjects (HS).

Results

Patients with CS showed a significant increase (P<0.05) of cIMT (0.89±0.17 mm) compared to EH (0.81±0.16 mm) and HS (0.75±0.4 mm), with a high prevalence of plaque (23%; P<0.03). Moreover, CS patients showed a mean ABI values (1.07±0.02) significantly lower respect to HS (1.12±0.11; P<0.05), and a higher percentage (20%) of pathological values of ABI (≤0.9; P<0.03).

Conclusion

In conclusion, we confirmed and extended the data of cIMT in CS, and showed that the ABI represent another surrogate marker of subclinical atherosclerosis in this disease.

Citations

Citations to this article as recorded by  
  • Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches
    Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski
    Biomedicines.2023; 11(8): 2284.     CrossRef
  • Capillary microarchitectural changes in Cushing's syndrome
    Tugce Apaydin, Yasemin Yalcinkaya, Can Ilgin, Dilek Gogas Yavuz
    Microvascular Research.2022; 141: 104323.     CrossRef
  • Glucocorticoid therapy is a risk factor for cardiovascular diseases
    I. S. Dzherieva, N. I. Volkova, I. Y. Davidenko, I. B. Reshetnikov, S. S. Brovkina, S. M. Avakova, Y. V. Tishchenko
    Medical Herald of the South of Russia.2022; 13(3): 93.     CrossRef
  • Glucocorticoids: Fuelling the Fire of Atherosclerosis or Therapeutic Extinguishers?
    Clare MacLeod, Patrick W. F. Hadoke, Mark Nixon
    International Journal of Molecular Sciences.2021; 22(14): 7622.     CrossRef
  • Cardiovascular and metabolic risk factors in patients with subclinical Cushing
    Luigi Petramala, Federica Olmati, Antonio Concistrè, Riccardo Russo, Martina Mezzadri, Maurizio Soldini, Giuseppe De Vincentis, Gino Iannucci, Giorgio De Toma, Claudio Letizia
    Endocrine.2020; 70(1): 150.     CrossRef
  • Should Cushing's Syndrome be Considered as a Disease with High Cardiovascular Risk in Relevant Guidelines?
    Goran Koracevic, Milan Stojkovic, Dragan Lovic, Milan Pavlovic, Tomislav Kostic, Marija Kutlesic, Sladjana Micic, Maja Koracevic, Milan Djordjevic
    Current Vascular Pharmacology.2019; 18(1): 12.     CrossRef
  • Markers of atherosclerosis in patients with Cushing’s syndrome: a meta-analysis of literature studies
    Roberta Lupoli, Pasquale Ambrosino, Anna Tortora, Livia Barba, Gelsy Arianna Lupoli, Matteo Nicola Dario Di Minno
    Annals of Medicine.2017; 49(3): 206.     CrossRef
Close layer
Clinical Study
Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer
Sang Mi Kim, Eun Heui Kim, Bo Hyun Kim, Jong Ho Kim, Su Bin Park, Yoon Jeong Nam, Kang Hee Ahn, Min Young Oh, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Ju Kim
Endocrinol Metab. 2015;30(4):494-501.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.494
  • 4,347 View
  • 47 Download
  • 34 Web of Science
  • 33 Crossref
AbstractAbstract PDFPubReader   
Background

Several inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and PLR in papillary thyroid cancer (PTC). We evaluated the association of the preoperative NLR and PLR with clinicopathological characteristics in patients with PTC.

Methods

This study included 1,066 female patients who underwent total thyroidectomy for PTC. Patients were stratified into 4 quartiles by preoperative NLR and PLR. And the combination of preoperative NLR and PLR was calculated on the basis of data obtained value of tertile as follows: patients with both an elevated PLR and an elevated NLR were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively.

Results

The preoperative NLR and PLR were significantly lower in patients aged ≥45 years and in patients with Hashimoto's thyroiditis. The PLR was significantly higher in patients with tumor size >1 cm (P=0.021).When the patients were categorized into the aforementioned four groups, the group with the higher preoperative PLR was found to have a significantly increased incidence of lateral lymph node metastasis (LNM) (P=0.018). However, there are no significant association between the combination of preoperative NLR and PLR and prognostic factors in PTC patients.

Conclusion

These results suggest that a preoperative high PLR were significant associated with lateral LNM in female patients with PTC.

Citations

Citations to this article as recorded by  
  • Preoperative serum inflammation-based scores in medullary thyroid cancer
    Ana Abrantes Figueiredo, Susana Esteves, Margarida Maria Moura, Pedro Marques, Joana Simões-Pereira, Valeriano Leite
    Endocrinología, Diabetes y Nutrición.2023; 70(1): 48.     CrossRef
  • Preoperative serum inflammation-based scores in medullary thyroid cancer
    Ana Abrantes Figueiredo, Susana Esteves, Margarida Maria Moura, Pedro Marques, Joana Simões-Pereira, Valeriano Leite
    Endocrinología, Diabetes y Nutrición (English ed.).2023; 70(1): 48.     CrossRef
  • Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis
    Elena Russo, Mathilda Guizzardi, Luca Canali, Francesca Gaino, Andrea Costantino, Gherardo Mazziotti, Andrea Lania, Silvia Uccella, Luca Di Tommaso, Fabio Ferreli, Luca Malvezzi, Giuseppe Spriano, Giuseppe Mercante
    Reviews in Endocrine and Metabolic Disorders.2023; 24(6): 1205.     CrossRef
  • Association of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Clinicopathological Features and Short-Term Outcome in Well-Differentiated Thyroid Cancer
    Sumeet Suresh Malapure, Sibi Oommen, Shivanand Bhushan, Sucharitha Suresh, K. Devaraja
    Indian Journal of Nuclear Medicine.2023; 38(4): 313.     CrossRef
  • The predictive value of hematologic parameters in the risk of thyroid malignancy in cases with atypia/follicular lesion of undetermined significance
    Hayri Bostan, Muhammed Erkam Sencar, Murat Calapkulu, Sema Hepsen, Pinar Akhanli, Hakan Duger, Bekir Ucan, Muhammed Kizilgul, Ilknur Ozturk Unsal, Mustafa Ozbek, Erman Cakal
    European Archives of Oto-Rhino-Laryngology.2022; 279(8): 4077.     CrossRef
  • Prognostic Impact of Inflammatory Markers PLR, LMR, PDW, MPV in Medullary Thyroid Carcinoma
    Canxiao Li, Han Zhang, Shijie Li, Daqi Zhang, Jingting Li, Gianlorenzo Dionigi, Nan Liang, Hui Sun
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The role of neutrophil to lymphocyte and platelet to lymphocyte ratios in diagnosing thyroid nodule
    HaiderSalim Mihson, AyadKhani Maikhan, AliRodan Shuwelif
    Mustansiriya Medical Journal.2022; 21(2): 155.     CrossRef
  • Comparison of Mean Platelet Volume, Platelet Distribution Width, Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Lymphocyte/Monocyte Ratio in Patients with Differentiated Thyroid Cancer According to TSH Levels
    Seher ÇETİNKAYA ALTUNTAŞ, Ömercan TOPALOĞLU
    Batı Karadeniz Tıp Dergisi.2022; 6(3): 302.     CrossRef
  • Delta Neutrophil Index and Neutrophil‐to‐Lymphocyte Ratio in the Differentiation of Thyroid Malignancy and Nodular Goiter
    Mehmet Buğra Bozan, Fatih Mehmet Yazar, İlhami Taner Kale, Mehmet Fatih Yüzbaşıoğlu, Ömer Faruk Boran, Ayşe Azak Bozan
    World Journal of Surgery.2021; 45(2): 507.     CrossRef
  • Factors Affecting Central Node Metastasis and Metastatic Lymph Node Ratio in Papillary Thyroid Cancer
    Jungirl Seok, Chang Hwan Ryu, Seog Yun Park, Chang Yoon Lee, Young Ki Lee, Yul Hwangbo, Eun Kyung Lee, You Jin Lee, Tae Sung Kim, Seok‐ki Kim, Yuh‐Seog Jung, Junsun Ryu
    Otolaryngology–Head and Neck Surgery.2021; 165(4): 519.     CrossRef
  • Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter
    Hakan BÖLÜKBAŞI, Serhan YILMAZ
    Ege Tıp Dergisi.2021; 60(1): 63.     CrossRef
  • Development and Validation of a Nomogram for Preoperative Prediction of Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma and Type 2 Diabetes Mellitus
    Chao He, Yiqiao Lu, Binqi Wang, Jie He, Haiguang Liu, Xiaohua Zhang
    Cancer Management and Research.2021; Volume 13: 2499.     CrossRef
  • The diagnostic predictive value of neutrophil-to-lymphocyte ratio in thyroid cancer adjusted for tumor size
    Taek Yoon Cheong, Sang Duk Hong, Keun-Woo Jung, Yoon Kyoung So, Paula Soares
    PLOS ONE.2021; 16(5): e0251446.     CrossRef
  • Usefulness of pre-thyroidectomy neutrophil–lymphocyte, platelet–lymphocyte, and monocyte–lymphocyte ratios for discriminating lymph node and distant metastases in differentiated thyroid cancer
    Cínthia Minatel Riguetto, Icléia Siqueira Barreto, Frederico Fernandes Ribeiro Maia, Lígia Vera Montali da Assumpção, Denise Engelbrecht Zantut-Wittmann
    Clinics.2021; 76: e3022.     CrossRef
  • Serum Inflammation-based Scores in Endocrine Tumors
    Pedro Marques, Friso de Vries, Olaf M Dekkers, Márta Korbonits, Nienke R Biermasz, Alberto M Pereira
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(10): e3796.     CrossRef
  • Diferansiye Tiroid Kanserli Hastalarda Preoperatif Nötrofil / Lenfosit Oranının Boyun Ultrasonografisi ve Patolojik Bulgularla İlişkisi
    Mehmet Esat DUYMUŞ
    Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi.2021; 54(2): 243.     CrossRef
  • Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
    Sorina Martin, Theodor Mustata, Oana Enache, Oana Ion, Andreea Chifulescu, Anca Sirbu, Carmen Barbu, Adrian Miron, Cosmin Giulea, Florin Andrei, Simona Fica
    Diagnostics.2021; 11(11): 1959.     CrossRef
  • The prognostic and diagnostic use of hematological parameters in subacute thyroiditis patients
    Murat Calapkulu, Muhammed Erkam Sencar, Davut Sakiz, Hakan Duger, Ilknur Ozturk Unsal, Mustafa Ozbek, Erman Cakal
    Endocrine.2020; 68(1): 138.     CrossRef
  • Association of the Preoperative Inflammation-Based Scores with TNM Stage and Recurrence in Patients with Papillary Thyroid Carcinoma: A Retrospective, Multicenter Analysis


    Wenjie Chen, Tao Wei, Zhihui Li, Rixiang Gong, Jianyong Lei, Jingqiang Zhu, Tao Huang
    Cancer Management and Research.2020; Volume 12: 1809.     CrossRef
  • Inflammatory biomarkers and dynamics of neutrophil-to-lymphocyte ratio in anaplastic thyroid carcinoma
    Haruhiko Yamazaki, Kiminori Sugino, Kenichi Matsuzu, Chie Masaki, Junko Akaishi, Kiyomi Hames, Chisato Tomoda, Akifumi Suzuki, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Munetaka Masuda, Koichi Ito
    Endocrine.2020; 70(1): 115.     CrossRef
  • Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment
    Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Jian Zhang
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Hipertiroidi Hastalarında Tedavi Öncesi ve Sonrası Trombosit/Lenfosit ve Nötrofil/Lenfosit Oranlarının Değerlendirilmesi
    Çiğdem CİNDOĞLU, Mehmet GÜLER, Mehmet Ali EREN, Tevfik SABUNCU
    Harran Üniversitesi Tıp Fakültesi Dergisi.2020; 17(1): 104.     CrossRef
  • Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma
    Faruk Kutluturk, Serdar S. Gul, Safak Sahin, Turker Tasliyurt
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2019; 19(6): 859.     CrossRef
  • The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition
    Gilda Varricchi, Stefania Loffredo, Giancarlo Marone, Luca Modestino, Poupak Fallahi, Silvia Martina Ferrari, Amato de Paulis, Alessandro Antonelli, Maria Rosaria Galdiero
    International Journal of Molecular Sciences.2019; 20(16): 3934.     CrossRef
  • Different prognostic values of individual hematologic parameters in papillary thyroid cancer due to age-related changes in immunity
    Kwan Ho Lee, Eun Young Seok, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Chan Heun Park
    Annals of Surgical Treatment and Research.2019; 96(2): 70.     CrossRef
  • Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres
    Dimitrios K. Manatakis, Sophia Tseleni-Balafouta, Lazaros Tzelves, Dimitrios Balalis, Adelais Tzortzopoulou, Dimitrios P. Korkolis, George H. Sakorafas, Emmanouil Gontikakis, Georgios Plataniotis
    Journal of Thyroid Research.2018; 2018: 1.     CrossRef
  • Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study
    Arif Emre, Sami Akbulut, Mehmet Sertkaya, Muharrem Bitiren, Ilhami Taner Kale, Ertan Bulbuloglu, Cemil Colak
    World Journal of Clinical Cases.2018; 6(3): 20.     CrossRef
  • Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions
    Nikolaos Machairas, Ioannis D. Kostakis, Anastasia Prodromidou, Paraskevas Stamopoulos, Themistoklis Feretis, Zoe Garoufalia, Christos Damaskos, Gerasimos Tsourouflis, Gregory Kouraklis
    Endocrine Research.2017; 42(4): 311.     CrossRef
  • Evaluation of Hemocytometer Parameters as Potential Biomarkers in Benign Multinodular Goiter and Papillary Thyroid Carcinoma
    Erdal Uysal, Seyit Mehmet Ceylan, Efe Sezgin, Hasan Bakir, Ahmet Orhan Gurer, Basar Aksoy, Mehmet Bastemir
    Iranian Red Crescent Medical Journal.2017;[Epub]     CrossRef
  • Clinical Value of Blood Neutrophil to Lymphocyte Ratio in Patients with Papillary Thyroid Carcinoma with Neck Lymph Node Metastasis
    Hwa Bin Kim, Hyoung Shin Lee, Sung Won Kim, Seok Won Jeon, Ji Ah Song, Kang Dae Lee
    International Journal of Thyroidology.2017; 10(2): 89.     CrossRef
  • Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
    Dimitrios K. Manatakis, Sofia Tseleni-Balafouta, Dimitrios Balalis, Vasiliki N. Soulou, Dimitrios P. Korkolis, George H. Sakorafas, Georgios Plataniotis, Emmanouil Gontikakis
    International Journal of Endocrinology.2017; 2017: 1.     CrossRef
  • Association of the preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with lymph node metastasis and recurrence in patients with medullary thyroid carcinoma
    Ke Jiang, Jianyong Lei, Wenjie Chen, Yanping Gong, Han Luo, Zhihui Li, Rixiang Gong, Jingqiang Zhu
    Medicine.2016; 95(40): e5079.     CrossRef
  • Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
    Ji-Feng Liu, Luo Ba, Hong Lv, Dan Lv, Jin-Tao Du, Xiao-Mei Jing, Ning-Jing Yang, Shao-Xin Wang, Chao Li, Xiao-Xia Li
    Scientific Reports.2016;[Epub]     CrossRef
Close layer
Clinical Study
Electrolyte Imbalance in Patients with Sheehan's Syndrome
Chur Hoan Lim, Ji Hyun Han, Joon Jin, Ji Eun Yu, Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Endocrinol Metab. 2015;30(4):502-508.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.502
  • 4,547 View
  • 45 Download
  • 8 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   
Background

We investigated the prevalence of electrolyte imbalance and the relationship between serum electrolyte and anterior pituitary hormone levels in patients with Sheehan's syndrome.

Methods

In a retrospective study, we investigated 78 patients with Sheehan's syndrome. We also included 95 normal control subjects who underwent a combined anterior pituitary hormone stimulation test and showed normal hormonal responses.

Results

In patients with Sheehan's syndrome, the serum levels of sodium, potassium, ionized calcium, magnesium, and inorganic phosphate were significantly lower than those in control subjects. The prevalence of hyponatremia, hypokalemia, hypocalcemia, hypomagnesemia, and hypophosphatemia in patients with Sheehan's syndrome was 59.0% (n=46), 26.9% (n=21), 35.9% (n=28), 47.4% (n=37), and 23.1% (n=18), respectively. Levels of sodium and ionized calcium in serum were positively correlated with levels of all anterior pituitary hormones (all P<0.05). Levels of potassium in serum were positively correlated with adrenocorticotrophic hormone (ACTH) and growth hormone (GH) levels (all P<0.05). Levels of inorganic phosphate in serum were positively correlated with levels of thyroid-stimulating hormone, prolactin, and GH (all P<0.05), and levels of magnesium in serum were positively correlated with delta ACTH (P<0.01).

Conclusion

Electrolyte imbalance was common in patients with Sheehan's syndrome. Furthermore, the degree of anterior pituitary hormone deficiency relates to the degree of electrolyte disturbance in patients with this disease.

Citations

Citations to this article as recorded by  
  • Myopathic syndrome revealing a rare condition: Sheehan syndrome, a case-based review
    Elena Gradinaru, Catalin Furculescu, Andreea Trandafir, Daniela Opris-Belinski, Ioana Cristina Saulescu
    Clinical Rheumatology.2023; 42(6): 1705.     CrossRef
  • Partial Sheehan’s syndrome with abdominal tuberculosis presented with pancytopenia and fluctuating thyroid profile: a case report
    Prashant Yadav, Md Anwarul Bari, Akash Saha, Sushmita Yadav, Amzad H. Khan
    Annals of Medicine & Surgery.2023; 85(3): 548.     CrossRef
  • Acute pituitary crisis after lumbar surgery: A case report
    Hui Wang, Xingrui Gong
    Medicine.2023; 102(48): e36294.     CrossRef
  • Long-term hepatic and cardiac health in patients diagnosed with Sheehan’s syndrome
    Liza Das, Jayaprakash Sahoo, Neelam Dahiya, Sunil Taneja, Sanjay Kumar Bhadada, Mohammad Hayat Bhat, Paramjeet Singh, Vanita Suri, Bashir Ahmad Laway, Pinaki Dutta
    Pituitary.2022; 25(6): 971.     CrossRef
  • Clinical, endocrine, metabolic profile, and bone health in Sheehan's syndrome
    Soumita Mandal, Pradip Mukhopadhyay, Mainak Banerjee, Sujoy Ghosh
    Indian Journal of Endocrinology and Metabolism.2020; 24(4): 338.     CrossRef
  • A rare endocrine cause of electrical storm - a case report
    Sunny D Shinde, Girish R Sabnis, Charan P Lanjewar, Prafulla G Kerkar
    European Heart Journal - Case Reports.2017;[Epub]     CrossRef
  • Sheehan syndrome
    Züleyha Karaca, Bashir A. Laway, Hatice S. Dokmetas, Hulusi Atmaca, Fahrettin Kelestimur
    Nature Reviews Disease Primers.2016;[Epub]     CrossRef
Close layer
Clinical Study
Clinical Characteristics of Subjects with Sulfonylurea-Dependent Type 2 Diabetes
Se Hee Min, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hye Seung Jung
Endocrinol Metab. 2015;30(4):509-513.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.509
  • 4,278 View
  • 64 Download
  • 3 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   
Background

Even though several oral anti-diabetic drugs (OAD) with various modes of action are replacing sulfonylurea (SU), some patients seem to be dependent on SU for adequate glycemic control. Therefore, we evaluated the clinical characteristics of such patients.

Methods

We selected the patients with type 2 diabetes who met following criteria from 2009 to 2014 at Seoul National University Hospital: glycated hemoglobin (HbA1c) was maintained below 7.5% for at least 6 months under small dose of SU (glimepiride ≤2 mg/day or equivalent dose); after discontinuation of SU, HbA1c increased ≥1.2% within 3 months or ≥1.5% within 6 months; and after resuming SU, HbA1c reduction was ≥0.8% or reduction of fasting plasma glucose was ≥40 mg/dL within 3 months. Patients with impaired hepatic or renal function, and steroid users were excluded.

Results

Nineteen subjects were enrolled: after averaged 4.8±1.5 months of SU-free period, HbA1c increased from 6.7%±0.4% to 8.8%±0.8% even though adding other OAD such as gliptins. However, HbA1c decreased to 7.4%±0.7% after resuming SU within 2.4±0.8 months. There was no sexual predominance. Despite their old age (67±11 years) and long duration of diabetes (18±10 years), fasting C-peptide was relatively well-reserved (3.9±2.6 ng/mL), and nephropathy was not observed (albumin-creatinine ratio 21.2±16.6 mg/g and estimated glomerular filtration rate 75.8±18.0 mL/min/1.73 m2). Strong family history was also noted (73.7%).

Conclusion

Despite hypoglycemia risk of SU, it seemed indispensable for a subset of patients with regard to insulin secretion. Genetic influences would be evaluated.

Citations

Citations to this article as recorded by  
  • Incident Hepatocellular Carcinoma Risk in Patients Treated with a Sulfonylurea: A Nationwide, Nested, Case-Control Study
    Ji-Yeon Lee, Suk-Yong Jang, Chung Mo Nam, Eun Seok Kang
    Scientific Reports.2019;[Epub]     CrossRef
  • A genetic variant in GLP1R is associated with response to DPP-4 inhibitors in patients with type 2 diabetes
    Eugene Han, Hye Sun Park, Obin Kwon, Eun Yeong Choe, Hye Jin Wang, Yong-ho Lee, Sang-Hak Lee, Chul Hoon Kim, Lee-Kyung Kim, Soo Heon Kwak, Kyong Soo Park, Chul Sik Kim, Eun Seok Kang
    Medicine.2016; 95(44): e5155.     CrossRef
Close layer
Clinical Study
Characterization of Patients with Type 2 Diabetes according to Body Mass Index: Korea National Health and Nutrition Examination Survey from 2007 to 2011
Dong-Hwa Lee, Kyong Yeun Jung, Kyeong Seon Park, Kyoung Min Kim, Jae Hoon Moon, Soo Lim, Hak Chul Jang, Sung Hee Choi
Endocrinol Metab. 2015;30(4):514-521.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.514
  • 3,441 View
  • 38 Download
  • 15 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   
Background

The present study aimed to investigate the clinical characteristics of type 2 diabetes mellitus (T2DM) in Korean adults according to body mass index (BMI) and to analyze the association with cardiovascular disease (CVD).

Methods

We conducted a cross-sectional study of data from the Korea National Health and Nutrition Examination Survey from 2007 to 2011. A total of 3,370 patients with T2DM were divided into categories according to BMI. We conducted a comparison of the T2DM patient population composition by BMI category between different countries. We investigated the prevalence of awareness, treatment, and target control of T2DM according to BMI.

Results

Patients with T2DM had a higher BMI, and were more likely to have a history of CVD than healthy controls. For Korean adults with T2DM, 8% had BMI ≥30 kg/m2. By contrast, the population of patients with T2DM and BMI ≥30 kg/m2 was 72% in patients in the USA and 56% in the UK. The rate of recognition, treatment, and control has worsened in parallel with increasing BMI. Even in patients with BMI 25 to 29.9 kg/m2, the prevalence of CVD or high risk factors for CVD was significantly higher than in patients with BMI 18.5 to 22.9 kg/m2 (odds ratio, 2.07).

Conclusion

Korean patients with T2DM had lower BMI than those in Western countries. Higher BMI was associated with lower awareness, treatment, and control of diabetes, and a positive association was observed between CVD or high risk factors for CVD and BMI, even for patients who were overweight but not obese.

Citations

Citations to this article as recorded by  
  • Influenza vaccination trend and related factors among patients with diabetes in Korea: Analysis using a nationwide database
    Dong-Hwa Lee, Bumhee Yang, Seonhye Gu, Eung-Gook Kim, Youlim Kim, Hyung Koo Kang, Yeong Hun Choe, Hyun Jeong Jeon, Seungyong Park, Hyun Lee
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diet Quality Scores and Asthenoteratozoospermia Risk: Finding From a Hospital-Based Case–Control Study in China
    Qi Cui, Hui-Han Wang, Qi-Jun Wu, Xiao-Bin Wang, Ren-Hao Guo, Xu Leng, Xiao-Ling Tan, Qiang Du, Bo-Chen Pan
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Obesity definition for personalised treatment of type 2 diabetes   Authors’ reply
    Ildiko Lingvay, Priya Sumithran, Ricardo V Cohen, Carel W le Roux
    The Lancet.2022; 399(10342): 2189.     CrossRef
  • Secular trends and determinants of influenza vaccination uptake among patients with cardiovascular disease in Korea: Analysis using a nationwide database
    Min Kim, Bumhee Yang, Seonhye Gu, Eung-Gook Kim, So Rae Kim, Kyeong Seok Oh, Woong-Su Yoon, Dae-Hwan Bae, Ju Hee Lee, Sang Min Kim, Woong Gil Choi, Jang-Whan Bae, Kyung-Kuk Hwang, Dong-Woon Kim, Myeong-Chan Cho, Hyun Lee, Dae-In Lee
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort
    Byoungjin Park, Hye Sun Lee, Yong-Jae Lee
    Translational Research.2021; 228: 42.     CrossRef
  • Gamitaeeumjowee-Tang for weight loss in diabetic patients: A retrospective chart review
    A-Reum Lee, Da-Yeon Lee, Min-Ji Kim, Hyang-Sook Lee, Ka-Hye Choi, Seo-Young Kim, Young-Woo Lim, Young-Bae Park
    Journal of Korean Medicine.2021; 42(1): 46.     CrossRef
  • Effect of cilostazol, a phosphodiesterase‐3 inhibitor, on coronary artery stenosis and plaque characteristics in patients with type 2 diabetes: ESCAPE study
    Dong‐Hwa Lee, Eun Ju Chun, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Lim
    Diabetes, Obesity and Metabolism.2019; 21(6): 1409.     CrossRef
  • The Differential Role of Vitamin D in Type 2 Diabetes Management and Control in Minority Populations
    Miyong To Kim, Kim Byeng Kim, Jisook Ko, Nicole Murry, David Levine, Ju-Young Lee
    Journal of Immigrant and Minority Health.2019; 21(6): 1266.     CrossRef
  • House dust mite and Cockroach specific Immunoglobulin E sensitization is associated with diabetes mellitus in the adult Korean population
    Mee Kyoung Kim, Jee Sun Jeong, Kyungdo Han, Ki Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Scientific Reports.2018;[Epub]     CrossRef
  • Long‐term effects on glycaemic control and β‐cell preservation of early intensive treatment in patients with newly diagnosed type 2 diabetes: A multicentre randomized trial
    Suk Chon, Sang Youl Rhee, Kyu Jeung Ahn, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Soon Jib Yoo, Gwanpyo Koh, Dae Ho Lee, Young Seol Kim, Jeong‐Taek Woo
    Diabetes, Obesity and Metabolism.2018; 20(5): 1121.     CrossRef
  • Association between Body Weight Changes and Menstrual Irregularity: The Korea National Health and Nutrition Examination Survey 2010 to 2012
    Kyung Min Ko, Kyungdo Han, Youn Jee Chung, Kun-Ho Yoon, Yong Gyu Park, Seung-Hwan Lee
    Endocrinology and Metabolism.2017; 32(2): 248.     CrossRef
  • Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients
    Yan Chen, Yong-Can Huang, Chun Hoi Yan, Kwong Yuen Chiu, Qingjun Wei, Jingmin Zhao, X Edward Guo, Frankie Leung, William W Lu
    Bone Research.2017;[Epub]     CrossRef
  • Social Networking Services-Based Communicative Care for Patients with Diabetes Mellitus in Korea
    Hun-Sung Kim, Yoo Jeong, Sun Baik, So Yang, Tong Kim, Hyunah Kim, Hyunyong Lee, Seung-Hwan Lee, Jae Cho, In-Young Choi, Kun-Ho Yoon
    Applied Clinical Informatics.2016; 07(03): 899.     CrossRef
  • Pharmacological Management of Obesity in Patients with Type 2 Diabetes: An Update
    Eun Ju Lee, Tae Nyun Kim
    The Korean Journal of Obesity.2016; 25(3): 121.     CrossRef
  • Response: Characterization of Patients with Type 2 Diabetes according to Body Mass Index: Korea National Health and Nutrition Examination Survey from 2007 to 2011 (Endocrinol Metab 2015;30:514-21, Dong-Hwa Lee et al.)
    Sung Hee Choi
    Endocrinology and Metabolism.2016; 31(2): 347.     CrossRef
  • Letter: Characterization of Patients with Type 2 Diabetes according to Body Mass Index: Korea National Health and Nutrition Examination Survey from 2007 to 2011 (Endocrinol Metab 2015;30:514-21, Dong-Hwa Lee et al.)
    Eun-Hee Cho
    Endocrinology and Metabolism.2016; 31(2): 345.     CrossRef
Close layer
Clinical Study
Metabolic Health Is More Important than Obesity in the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Retrospective Study
Min-Kyung Lee, Eun-Jung Rhee, Min Chul Kim, Byung Sub Moon, Jeong In Lee, Young Seok Song, Eun Na Han, Hyo Sun Lee, Yoonjeong Son, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Endocrinol Metab. 2015;30(4):522-530.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.522
  • 4,216 View
  • 59 Download
  • 23 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   
Background

The aim of this study is to compare the risk for future development of nonalcoholic fatty liver disease (NAFLD) according to different status of metabolic health and obesity.

Methods

A total of 3,045 subjects without NAFLD and diabetes at baseline were followed for 4 years. Subjects were categorized into four groups according to the following baseline metabolic health and obesity statuses: metabolically healthy, non-obese (MHNO); metabolically healthy, obese (MHO); metabolically unhealthy, non-obese (MUHNO); and metabolically unhealthy, obese (MUHO). Being metabolically healthy was defined as having fewer than two of the following five components: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostasis model assessment-insulin resistance index. Obesity was defined as a body mass index >25 kg/m2. The presence of NAFLD was assessed by ultrasonography.

Results

The proportions of subjects included in the MHNO, MHO, MUHNO, and MUHO groups were 71.4%, 9.8%, 13.0%, and 5.8%, respectively. The proportions of subjects who developed NAFLD were 10.5%, 31.4%, 23.2%, and 42% in the MHNO, MHO, MUHNO, and MUHO groups, respectively. The risk for developing NAFLD was highest in subjects who were metabolically unhealthy both at baseline and after 4 years compared with subjects who were consistently metabolically healthy during the follow-up period (odds ratio, 2.862). Using the MHNO group as reference, the odds ratios for the MHO, MUHNO, and MUHO groups were 1.731, 1.877, and 2.501, respectively.

Conclusion

The risk for NAFLD was lower in MHO subjects than in MUNO subjects.

Citations

Citations to this article as recorded by  
  • Increased metabolic variability in Korean patients with new onset bipolar disorder: a nationwide cohort study
    Ji Hyun Baek, Kyungdo Han, Hyewon Kim, Kyojin Yang, Hong Jin Jeon
    Frontiers in Psychiatry.2024;[Epub]     CrossRef
  • Increased risk of incident atrial fibrillation in young adults with mental disorders: A nationwide population-based study
    Hyun Jin Ahn, So-Ryoung Lee, Eue-Keun Choi, Nan Young Bae, Hyo-Jeong Ahn, Soonil Kwon, Seung-Woo Lee, Kyung-Do Han, Seil Oh, Gregory Y.H. Lip
    Heart Rhythm.2023; 20(3): 365.     CrossRef
  • Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis
    Wolhwa Song, Sung Hwan Yoo, Jinsun Jang, Su Jung Baik, Byoung Kwon Lee, Hyun Woong Lee, Jong Suk Park
    Gut and Liver.2023; 17(1): 130.     CrossRef
  • The impact of metabolic health on non-alcoholic fatty liver disease (NAFLD). A single center experience
    Anna Boulouta, Ioanna Aggeletopoulou, Stavros Kanaloupitis, Efthymios P Tsounis, Vasileios Issaris, Konstantinos Papantoniou, Anastasios Apostolos, Paraskevas Tsaplaris, Ploutarchos Pastras, Christos Sotiropoulos, Aggeliki Tsintoni, Georgia Diamantopoulou
    Clinics and Research in Hepatology and Gastroenterology.2022; 46(5): 101896.     CrossRef
  • Lean non-alcoholic fatty liver disease (Lean-NAFLD) and the development of metabolic syndrome: a retrospective study
    Wenting Wang, Jianping Ren, Wenzhao Zhou, Jinyu Huang, Guomin Wu, Fenfang Yang, Shuang Yuan, Juan Fang, Jing Liu, Yao Jin, Haiyang Qi, Yuyang Miao, Yanna Le, Cenhong Ge, Xiantao Qiu, JinJing Wang, Ping Huang, Zixin Liu, Sheng Wang
    Scientific Reports.2022;[Epub]     CrossRef
  • Metabolically healthy obesity and risk of non‐alcoholic fatty liver disease severity independent of visceral fat
    Tsung‐Po Chen, Wen‐Yuan Lin, Chien‐Hsieh Chiang, Ting‐Hsin Shen, Kuo‐Chin Huang, Kuen‐Cheh Yang
    Journal of Gastroenterology and Hepatology.2021; 36(10): 2903.     CrossRef
  • Increased metabolic variability is associated with newly diagnosed depression: A nationwide cohort study
    Ji Hyun Baek, Dong Wook Shin, Maurizio Fava, David Mischoulon, Hyewon Kim, Mi Jin Park, Eun Ji Kim, Kyung-Do Han, Hong Jin Jeon
    Journal of Affective Disorders.2021; 294: 786.     CrossRef
  • The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation
    Susanna Cirera, Emirhan Taşöz, Mette Juul Jacobsen, Camilla Schumacher-Petersen, Berit Østergaard Christoffersen, Rikke Kaae Kirk, Trine Pagh Ludvigsen, Henning Hvid, Henrik Duelund Pedersen, Lisbeth Høier Olsen, Merete Fredholm
    Nutrition & Diabetes.2020;[Epub]     CrossRef
  • Impact of obesity and metabolic health status in the development of non-alcoholic fatty liver disease (NAFLD): A United Kingdom population-based cohort study using the health improvement network (THIN)
    A. Vusirikala, T. Thomas, N. Bhala, A. A. Tahrani, G. N. Thomas, K. Nirantharakumar
    BMC Endocrine Disorders.2020;[Epub]     CrossRef
  • Epidemiology of nonalcoholic fatty liver disease in non‐obese populations: Meta‐analytic assessment of its prevalence, genetic, metabolic, and histological profiles
    Zi Yuan Zou, Vincent Wai‐Sun Wong, Jian Gao Fan
    Journal of Digestive Diseases.2020; 21(7): 372.     CrossRef
  • Ultrasound-Diagnosed Nonalcoholic Fatty Liver Disease Independently Predicts a Higher Risk of Developing Diabetes Mellitus in Nonoverweight Individuals
    Liang Wang
    Academic Radiology.2019; 26(7): 863.     CrossRef
  • Blood Pressure and Development of Cardiovascular Disease in Koreans With Type 2 Diabetes Mellitus
    Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
    Hypertension.2019; 73(2): 319.     CrossRef
  • Understanding the association of polycystic ovary syndrome and non-alcoholic fatty liver disease
    Nicolás Salva-Pastor, Norberto C. Chávez-Tapia, Misael Uribe, Natalia Nuño-Lámbarri
    The Journal of Steroid Biochemistry and Molecular Biology.2019; 194: 105445.     CrossRef
  • Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
    Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Longitudinal analysis of risk of non‐alcoholic fatty liver disease in adulthood
    Daniel J. Cuthbertson, Emily Brown, Juha Koskinen, Costan G. Magnussen, Nina Hutri‐Kähönen, Matthew Sabin, Päivi Tossavainen, Eero Jokinen, Tomi Laitinen, Jorma Viikari, Olli T. Raitakari, Markus Juonala
    Liver International.2019; 39(6): 1147.     CrossRef
  • Associations of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Mass Index With Mortality and Cardiovascular Outcomes in the General Population
    Mee Kyoung Kim, Kyungdo Han, Yong-Moon Park, Hyuk-Sang Kwon, Gunseog Kang, Kun-Ho Yoon, Seung-Hwan Lee
    Circulation.2018; 138(23): 2627.     CrossRef
  • The effects of metabolic status on non‐alcoholic fatty liver disease‐related outcomes, beyond the presence of obesity
    Javier Ampuero, Rocío Aller, Rocío Gallego‐Durán, Jesus M. Banales, Javier Crespo, Carmelo García‐Monzón, María Jesús Pareja, Eduardo Vilar‐Gómez, Juan Caballería, Desamparados Escudero‐García, Judith Gomez‐Camarero, José Luis Calleja, Mercedes Latorre, A
    Alimentary Pharmacology & Therapeutics.2018; 48(11-12): 1260.     CrossRef
  • Dissecting the relationship between obesity and hyperinsulinemia: Role of insulin secretion and insulin clearance
    Mee Kyoung Kim, Gerald M. Reaven, Sun H. Kim
    Obesity.2017; 25(2): 378.     CrossRef
  • The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
    Katherine González-Ruiz, Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Mark D. Peterson, Antonio García-Hermoso
    Childhood Obesity.2017; 13(4): 272.     CrossRef
  • Clinical Characteristics of Non-Alcoholic Fatty Liver Disease Based on Analyses from the Kangbuk Samsung Health Study
    Eun-Jung Rhee
    The Journal of Korean Diabetes.2017; 18(2): 81.     CrossRef
  • Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases
    Eugene Han, Yong-ho Lee
    Diabetes & Metabolism Journal.2017; 41(6): 430.     CrossRef
  • Predictive Value of Triglyceride Glucose Index for the Risk of Incident Diabetes: A 4-Year Retrospective Longitudinal Study
    Da Young Lee, Eun Seo Lee, Ji Hyun Kim, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Won-Young Lee, Fernando Guerrero-Romero
    PLOS ONE.2016; 11(9): e0163465.     CrossRef
  • Lean, but not healthy
    Cherlyn Ding, Zhiling Chan, Faidon Magkos
    Current Opinion in Clinical Nutrition & Metabolic Care.2016; 19(6): 408.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism