Cushing's syndrome, a potentially lethal disorder characterized by endogenous hypercortisolism, may be difficult to recognize, especially when it is mild and the presenting features are common in the general population. However, there is a need to identify the condition at an early stage, as it tends to progress, accruing additional morbidity and increasing mortality rates. Once a clinical suspicion is raised, screening tests involve timed measurement of urine, serum or salivary cortisol at baseline or after administration of dexamethasone, 1 mg. Each test has caveats, so that the choice of tests must be individualized for each patient. Once the diagnosis is established, and the cause is determined, surgical resection of abnormal tumor/tissue is the optimal treatment. When this cannot be achieved, medical treatment (or bilateral adrenalectomy) must be used to normalize cortisol production. Recent updates in screening for and treating Cushing's syndrome are reviewed here.

Citations

Citations to this article as recorded by  

• Steroid as a Saviour and Culprit in Pemphigus Vulgaris Therapy: A Rare Case Series
  Deepthi Avvaru, Raushan Kumar Chaudhary, Bhavana Doshi, Ramesh Bhandari
  Current Drug Therapy.2024; 19(3): 360.     CrossRef
• Exploring alternative treatment options for a patient with acute disseminated encephalomyelitis (ADEM) suffering from iatrogenic Cushing’s symptoms
  Alejandro Ponce Sepulveda
  Clinical Research In Practice: The Journal of Team Hippocrates .2024;[Epub]     CrossRef
• Considerations for cutaneous physiologic changes of pregnancy that fail to resolve postpartum
  Madison J. Anzelc, Mark A. Bechtel
  International Journal of Dermatology.2023; 62(2): 190.     CrossRef
• Hypertension in Turner syndrome: a review of proposed mechanisms, management and new directions
  Lily Jones, Joanne Blair, Daniel B. Hawcutt, Gregory Y.H. Lip, Alena Shantsila
  Journal of Hypertension.2023; 41(2): 203.     CrossRef
• Methyl-Prednisolone and Betamethasone Induced Iatrogenic Cushing Syndrome - A Rare Case Report
  Faaiz Khan, Jumana Hakeem, Mitta Raghavendra, Sushanta Kumar Das, Vallala Venakata Rajesham, Tadikonda Rama Rao
  International Journal of Pharmaceutical Research and Allied Sciences.2023; 12(2): 40.     CrossRef
• Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer
  Aliya Lakhani, Da Hyun Kang, Yea Eun Kang, Junyoung O. Park
  Endocrinology and Metabolism.2023; 38(6): 619.     CrossRef
• Metabolic profile differences in ACTH‐dependent and ACTH‐independent Cushing syndrome
  Zhengyang Li, Chen Zhang, Chong Geng, Yongfeng Song
  Chronic Diseases and Translational Medicine.2022; 8(1): 36.     CrossRef
• Stressing the need for validated measures of cortisol in HIV research: A scoping review
  Shayda A. Swann, Elizabeth M. King, Hélène C. F. Côté, Melanie C. M. Murray
  HIV Medicine.2022; 23(8): 880.     CrossRef
• Concomitant coexistence of ACTH‐dependent and independent Cushing syndrome
  Ach Taieb, Saad Ghada, Gorchène Asma, Ben Abdelkrim Asma, Kacem Maha, Ach Koussay
  Clinical Case Reports.2022;[Epub]     CrossRef
• Incretin Response to Mixed Meal Challenge in Active Cushing’s Disease and after Pasireotide Therapy
  Mattia Barbot, Alessandro Mondin, Daniela Regazzo, Valentina Guarnotta, Daniela Basso, Carla Giordano, Carla Scaroni, Filippo Ceccato
  International Journal of Molecular Sciences.2022; 23(9): 5217.     CrossRef
• Intermittent Blurry Vision: An Unexpected Presentation of Cushing’s Syndrome Due to Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH)
  Christopher Fernandez, Smriti Bhatia, Ariana Rucker, Lee Celio
  Cureus.2022;[Epub]     CrossRef
• Recurrent Metatarsal Fractures in a Patient With Cushing Disease: A Case Report
  Jose Iturregui, Glenn Shi
  Cureus.2022;[Epub]     CrossRef
• Recognising and diagnosing Cushing’s syndrome in primary care: challenging but not impossible
  Kate Scoffings, Damian Morris, Andrew Pullen, Sharon Temple, Anna Trigell, Mark Gurnell
  British Journal of General Practice.2022; 72(721): 399.     CrossRef
• Recurrent Cushing Syndrome From Metastatic Adrenocortical Carcinoma With Fumarate Hydratase Allelic Variant
  Emily Silverman, Noor Addasi, Muaataz Azzawi, Ernesto Martinez Duarte, Dali Huang, Benjamin Swanson, Apar Kishor Ganti, Gwen Reiser, Abbey L. Fingeret, Anupam Kotwal
  AACE Clinical Case Reports.2022; 8(6): 259.     CrossRef
• Multiple Bone Fractures in a Patient With Difficult-to-Treat Cushing’s Disease
  Sara Correia, Diogo Ramalho, Gustavo Rocha, Maria J Oliveira
  Cureus.2022;[Epub]     CrossRef
• Management of patients on systemic steroids: An oral surgery perspective
  Vikash Patel, Shrina Nathwani, Naomi Rahman
  Dental Update.2022; 49(9): 749.     CrossRef
• Importancia del cateterismo de senos petrosos inferiores en el diagnóstico de síndrome de Cushing, a propósito de un caso
  Clara Jiménez García, Paula Sirera Sirera, María Eugenia Torregrosa Quesada, Victoria González Bueno, Rocío Alfayate Guerra
  Advances in Laboratory Medicine / Avances en Medicina de Laboratorio.2022; 3(4): 411.     CrossRef
• Cushing's Syndrome Behind Hypokalemia and Severe Infection: A Case Report
  Catarina Elias, Diana Oliveira, Maria Manuel Silva, Patrícia Lourenço
  Cureus.2022;[Epub]     CrossRef
• Relevance of inferior petrosal sinus sampling in the diagnosis of Cushing’s syndrome: a case report
  Clara Jiménez García, Paula Sirera Sirera, María Eugenia Torregrosa Quesada, Victoria González Bueno, Rocío Alfayate Guerra
  Advances in Laboratory Medicine / Avances en Medicina de Laboratorio.2022; 3(4): 407.     CrossRef
• Proximal muscle weakness as the sole manifestation of Cushing’s disease, misdiagnosed as dermatomyositis: a case report
  Marjan Jeddi, Mesbah Shams
  Journal of Medical Case Reports.2022;[Epub]     CrossRef
• Differences in outcomes of bilateral adrenalectomy in patients with ectopic ACTH producing tumor of known and unknown origin
  Thomas Szabo Yamashita, Alaa Sada, Irina Bancos, William F. Young, Benzon M Dy, David R. Farley, Melanie L. Lyden, Geoffrey B. Thompson, Travis J. McKenzie
  The American Journal of Surgery.2021; 221(2): 460.     CrossRef
• A key role for conservative treatment in the management of pituitary apoplexy
  Claire Marx, Muriel Rabilloud, Françoise Borson Chazot, Caroline Tilikete, Emmanuel Jouanneau, Gerald Raverot
  Endocrine.2021; 71(1): 168.     CrossRef
• 7-T Magnetic Resonance Imaging in the Management of Brain Tumors
  Melanie A. Morrison, Janine M. Lupo
  Magnetic Resonance Imaging Clinics of North America.2021; 29(1): 83.     CrossRef
• Medical therapy in severe hypercortisolism
  Júlia Vieira Oberger Marques, Cesar Luiz Boguszewski
  Best Practice & Research Clinical Endocrinology & Metabolism.2021; 35(2): 101487.     CrossRef
• Metabolic changes in serum steroids for diagnosing and subtyping Cushing’s syndrome
  Chang Ho Ahn, Chaelin Lee, Jaeyoon Shim, Sung Hye Kong, Su-jin Kim, Yong Hwy Kim, Kyu Eun Lee, Chan Soo Shin, Jung Hee Kim, Man Ho Choi
  The Journal of Steroid Biochemistry and Molecular Biology.2021; 210: 105856.     CrossRef
• Method-Specific Cortisol and Dexamethasone Thresholds Increase Clinical Specificity of the Dexamethasone Suppression Test for Cushing Syndrome
  Nora Vogg, Max Kurlbaum, Timo Deutschbein, Benedict Gräsl, Martin Fassnacht, Matthias Kroiss
  Clinical Chemistry.2021; 67(7): 998.     CrossRef
• Untargeted Plasma Metabolomics Unravels a Metabolic Signature for Tissue Sensitivity to Glucocorticoids in Healthy Subjects: Its Implications in Dietary Planning for a Healthy Lifestyle
  Nicolas C. Nicolaides, Maria-Konstantina Ioannidi, Eleni Koniari, Ifigeneia Papageorgiou, Anastasia Bartzeliotou, Amalia Sertedaki, Maria I. Klapa, Evangelia Charmandari
  Nutrients.2021; 13(6): 2120.     CrossRef
• Endocrine hypertension secondary to adrenal tumors: clinical course and predictive factors of clinical remission
  Uriel Clemente-Gutiérrez, Rafael H. Pérez-Soto, Juan D. Hernández-Acevedo, Nicole M. Iñiguez-Ariza, Enrique Casanueva-Pérez, Juan Pablo Pantoja-Millán, Mauricio Sierra-Salazar, Miguel F. Herrera, David Velázquez-Fernández
  Langenbeck's Archives of Surgery.2021; 406(6): 2027.     CrossRef
• Development of 68Ga DOTA-CRH for PET/CT Imaging of ACTH-Dependent Cushing's Disease: Initial Study
  Jaya Shukla, Rakhee Vatsa, Rama Walia, Anupriya Chhabra, Nivedita Rana, Harmandeep Singh, Rajender Kumar, Bhagwant Rai Mittal
  Cancer Biotherapy and Radiopharmaceuticals.2021; 36(8): 642.     CrossRef
• Cushing Syndrome Associated Myopathy: It Is Time for a Change
  Martin Reincke
  Endocrinology and Metabolism.2021; 36(3): 564.     CrossRef
• Cushing’s disease presenting with psychosis
  Ahmed Saeed Mubarak Mohamed, Ahmed Iqbal, Suveera Prasad, Nigel Hoggard, Daniel Blackburn
  Practical Neurology.2021; 21(4): 351.     CrossRef
• ACTH-independent Cushing's syndrome due to bilateral adrenocortical adenoma: A case report
  Majd Sharaf, Rama Al-Saqqa, Mouhammad Kourabi
  Radiology Case Reports.2021; 16(11): 3168.     CrossRef
• A New Clinical Model to Estimate the Pre-Test Probability of Cushing’s Syndrome: The Cushing Score
  Mirko Parasiliti-Caprino, Fabio Bioletto, Tommaso Frigerio, Valentina D’Angelo, Filippo Ceccato, Francesco Ferraù, Rosario Ferrigno, Marianna Minnetti, Carla Scaroni, Salvatore Cannavò, Rosario Pivonello, Andrea Isidori, Fabio Broglio, Roberta Giordano, M
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Bilateral Adrenalectomy: Differences between Cushing Disease and Ectopic ACTH-Producing Tumors
  Thomas Szabo Yamashita, Alaa Sada, Irina Bancos, William F. Young, Benzon M. Dy, David R. Farley, Melanie L. Lyden, Geoffrey B. Thompson, Travis J. McKenzie
  Annals of Surgical Oncology.2020; 27(10): 3851.     CrossRef
• Decision-Making in Artificial Intelligence: Is It Always Correct?
  Hun-Sung Kim
  Journal of Korean Medical Science.2020;[Epub]     CrossRef
• Cushing's syndrome: Overview of clinical presentation, diagnostic tools and complications
  Mattia Barbot, Marialuisa Zilio, Carla Scaroni
  Best Practice & Research Clinical Endocrinology & Metabolism.2020; 34(2): 101380.     CrossRef
• Cortisol Measurements in Cushing’s Syndrome: Immunoassay or Mass Spectrometry?
  Gregori Casals, Felicia Alexandra Hanzu
  Annals of Laboratory Medicine.2020; 40(4): 285.     CrossRef
• Cardiopatías de origen endocrino: una etiología frecuentemente olvidada
  Laura Duque-González, Luis Miguel Ruiz-Velásquez, José Luis Torres-Grajales, Mauricio Duque-Ramírez
  Medicina y Laboratorio.2020; 24(3): 207.     CrossRef
• Reference ranges of late-night salivary cortisol and cortisone measured by LC–MS/MS and accuracy for the diagnosis of Cushing’s syndrome
  F. Ponzetto, F. Settanni, M. Parasiliti-Caprino, F. Rumbolo, A. Nonnato, M. Ricciardo, E. Amante, G. Priolo, S. Vitali, L. Anfossi, E. Arvat, E. Ghigo, R. Giordano, G. Mengozzi
  Journal of Endocrinological Investigation.2020; 43(12): 1797.     CrossRef
• Assessment of 1 mg Dexamethasone Suppression Test in Patients with Obesity Before Bariatric Surgery
  Dilek Gogas Yavuz, Tugce Apaydin, Hatice Gizem Gunhan, Meliha Melin Uygur
  Obesity Surgery.2020; 30(12): 4981.     CrossRef
• Prospective Evaluation of Late-Night Salivary Cortisol and Cortisone by EIA and LC-MS/MS in Suspected Cushing Syndrome
  Joshua Kannankeril, Ty Carroll, James W Findling, Bradley Javorsky, Ian L Gunsolus, Jonathan Phillips, Hershel Raff
  Journal of the Endocrine Society.2020;[Epub]     CrossRef
• Infantile Iatrogenic Cushing Syndrome due to Topical Steroids
  Lulwah Alkhuder, Horia Mawlawi
  Case Reports in Pediatrics.2019; 2019: 1.     CrossRef
• Synchronous bilateral adrenalectomy in ACTH-dependent hypercortisolism: predictors, biomarkers and outcomes
  S. Chiloiro, A. Giampietro, M. Raffaelli, G. D’Amato, C. Bima, L. Lauretti, C. Anile, C. P. Lombardi, G. Rindi, R. Bellantone, L. De Marinis, A. Pontecorvi, A. Bianchi
  Endocrine.2019; 66(3): 642.     CrossRef
• Low-dose etomidate for the management of severe hypercortisolaemia in different clinical scenarios: a case series and review of the literature
  Agnieszka Łebek-Szatańska, Karolina M. Nowak, Wojciech Zgliczyński, Elżbieta Baum, Agnieszka Żyłka, Lucyna Papierska
  Therapeutic Advances in Endocrinology and Metabolism.2019;[Epub]     CrossRef
• Drug design strategies for Cushing’s syndrome
  S. A. Usanov, A. V. Kliuchenovich, N. V. Strushkevich
  Expert Opinion on Drug Discovery.2019; 14(2): 143.     CrossRef
• Pharmacological and analytical interference in hormone assays for diagnosis of adrenal incidentaloma
  Antoine-Guy Lopez, François Fraissinet, Herve Lefebvre, Valéry Brunel, Frédéric Ziegler
  Annales d'Endocrinologie.2019; 80(4): 250.     CrossRef
• Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
  Daniela D’Angelo, Marco De Martino, Claudio Arra, Alfredo Fusco
  Cancers.2019; 11(9): 1302.     CrossRef
• Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing’s Syndrome Rat Model
  Atsushi Yasuda, Toshiro Seki, Yoshie Kametani, Masahiro Koizumi, Natsumi Kitajima, Masayuki Oki, Masami Seki, Takatoshi Kakuta, Masafumi Fukagawa
  International Journal of Endocrinology.2019; 2019: 1.     CrossRef
• Cushing’s Disease
  Hiroshi Nishioka, Shozo Yamada
  Journal of Clinical Medicine.2019; 8(11): 1951.     CrossRef

Autoimmune diabetes is a heterogeneous disease which can arise at any age. Subjects with adult-onset autoimmune diabetes who do not necessitate insulin-therapy for at least 6 months after diagnosis are demarcated as having latent autoimmune diabetes in adults (LADA). This condition is more heterogeneous than young-onset autoimmune diabetes and shares clinical and metabolic characteristics with both type 2 and type 1 diabetes. Patients with LADA are considered by having highly variable β-cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, suggesting different pathophysiological pathways partially explaining the heterogeneous phenotypes of LADA. To date the heterogeneity of LADA does not allow to establish a priori treatment algorithm and no specific guidelines for LADA therapy are available. These subjects are mostly treated as affected by type 2 diabetes, a factor that might lead to the progression to insulin-dependency quickly. A personalised medicine approach is necessary to attain optimal metabolic control and preserve β-cell function to decrease the risk of long-term diabetes complications. Recent data concerning the use of oral antidiabetic agents as dipeptidyl peptidase 4 inhibitors and glucagon-like peptide 1 receptor agonists indicate up-and-coming results in term of protect C-peptide levels and improving glycaemic control. This review summarises current knowledge on LADA, emphasising controversies regarding its pathophysiology and clinical features. Moreover, we discuss data available about novel therapeutic approaches that can be considered for prevention of β-cell loss in LADA.

Citations

Citations to this article as recorded by  

• Utility of Fasting C-Peptide for the Diagnostic Differentiation of Patients with Type 1, Type 2 Diabetes, MODY, and LADA
  Ricardo Alemán-Contreras, Rita A. Gómez-Díaz, Maura E. Noyola-García, Rafael Mondragón-González, Niels Wacher, Aldo Ferreira-Hermosillo
  Life.2024; 14(5): 550.     CrossRef
• Latent autoimmune diabetes in adults: current data (review of literature and own data)
  N.V. Pashkovska, I.O. Tsaryk
  INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2024; 20(3): 163.     CrossRef
• Characterization of Turner Syndrome-associated Diabetes Mellitus
  Antoinette Cameron-Pimblett, Clementina La Rosa, Melanie C Davies, Jenifer P Suntharalingham, Miho Ishida, John C Achermann, Gerard S Conway
  The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
• Latent Autoimmune Diabetes in Adults (LADA) Occurring in a Patient with Primary Biliary Cholangitis
  Byung K. Lee, Kevin Pak, Paul J. Pockros
  The American Journal of Medicine.2024;[Epub]     CrossRef
• Dyslipidemia in latent autoimmune diabetes in adults: the relationship with vitamin D
  I.O. Tsaryk, N.V. Pashkovska, V.I. Pankiv, V.M. Pashkovskyy
  INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2024; 20(5): 357.     CrossRef
• Latent Autoimmune Diabetes in a Young Female: A Case Report
  Keerthana K Pampapathi, Hsu Y Mon, Joshua M Ibrahim, Samson O Oyibo
  Cureus.2024;[Epub]     CrossRef
• GLP-1 receptor agonist–induced diabetic ketoacidosis: A case report
  Jiaming Zhang, Ying Ma, Qianhe Zu, Xiaohui Wang, Yao Zhang
  Medicine.2024; 103(39): e39799.     CrossRef
• Global Trends in LADA Type Diabetes Research: A Bibliometric Analysis of Publications from Web of Science and Scopus, 1994–2024
  Khatimya Kudabayeva, Bibigul Tleumagambetova, Yerlan Bazargaliyev, Raikul Kosmuratova, Aliya Zhylkybekova, Liping Yu
  Journal of Diabetes Research.2024;[Epub]     CrossRef
• The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus
  Maryah Liepert, Shamayel Alhaqqan, Alaa Husain, Heather Lochnan, Ronald A. Booth, Julie Shaw, Cathy J. Sun
  Clinical Biochemistry.2024; : 110842.     CrossRef
• Drug candidates and potential targets ofCurculigospp. compounds for treating diabetes mellitus based on network pharmacology, molecular docking and molecular dynamics simulation
  Abdul Halim Umar, Diah Ratnadewi, Mohamad Rafi, Yohana Caecilia Sulistyaningsih, Hamim Hamim, Wisnu Ananta Kusuma
  Journal of Biomolecular Structure and Dynamics.2023; 41(17): 8544.     CrossRef
• Development and validation of a clinical score for identifying patients with high risk of latent autoimmune adult diabetes (LADA): The LADA primary care-protocol study
  Pilar Vich-Pérez, Juan Carlos Abánades-Herranz, Gustavo Mora-Navarro, Ángela María Carrasco-Sayalero, Miguel Ángel Salinero-Fort, Ignacio Sevilla-Machuca, Mar Sanz-Pascual, Cristina Álvarez Hernández-Cañizares, Carmen de Burgos-Lunar, Vijayaprakash Suppia
  PLOS ONE.2023; 18(2): e0281657.     CrossRef
• Diagnostic Dilemmas and Current Treatment Approaches in Latent Onset Autoimmune Diabetes in Adults: A Concise Review
  Lakshmi Chandran, Ankul Singh S., Chitra Vellapandian
  Current Diabetes Reviews.2023;[Epub]     CrossRef
• Characteristics of adult-onset auto-immune type 1 diabetes
  Faten Hadj Kacem, Ameni Jerbi, Bibi Twaheerah Allymamod, Wafa Bel Abed, Mouna Mnif, Nadia Charfi, Mouna Elleuch, Nabila Rekik, Hatem Masmoudi, Mohamed Abid
  The American Journal of the Medical Sciences.2023; 366(1): 49.     CrossRef
• The role of cholecalciferol deficiency in the development of latent autoimmune diabetes in adults
  I.O. Tsaryk, N.V. Pashkovska
  INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(4): 259.     CrossRef
• Newly diagnosed type 1 diabetes mellitus in a human immunodeficiency virus-infected patient with antiretroviral therapy-induced immune reconstitution inflammatory syndrome: a case report
  Min-ChunYeh, Han-Chuan Chuang, Shuen-Fu Weng, Chung-Huei Hsu, Chen-Ling Huang, Yu-Pei Lin, Yan-Yu Lin, Yu-Shan Hsieh
  BMC Infectious Diseases.2023;[Epub]     CrossRef
• A Review on Latent Autoimmune Diabetes in Adults
  Vijay Ravikumar, Ariba Ahmed, Ashish Anjankar
  Cureus.2023;[Epub]     CrossRef
• Exploring Immune Therapies in a Twin Case of Latent Autoimmune Diabetes in Adults and Generalized Granuloma Annulare
  Brian W. Connor, Sarah E.B. Smith, Andrea Kalus
  Clinical Diabetes.2023; 41(4): 583.     CrossRef
• Innate immunity in latent autoimmune diabetes in adults
  Juan Huang, James Alexander Pearson, F. Susan Wong, Li Wen, Zhiguang Zhou
  Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
• Endocrine Manifestations and New Developments in Mitochondrial Disease
  Yi Shiau Ng, Albert Zishen Lim, Grigorios Panagiotou, Doug M Turnbull, Mark Walker
  Endocrine Reviews.2022; 43(3): 583.     CrossRef
• Two Fifth-Generation Fighter Pilots Discovered with Latent Autoimmune Diabetes
  Joe X. Zhang, Jacob Berry, Nathan M. Kim, Justin J. Gray, Savannah Fotheringham, Tom J. Sauerwein
  Aerospace Medicine and Human Performance.2022; 93(2): 106.     CrossRef
• A Case of Late Diagnosis of Latent Autoimmune Diabetes in Adults
  Joana R Costa, Ana Mestre, Mariana S Miranda, Frederica H Ferreira, Yahia Abuowda
  Cureus.2022;[Epub]     CrossRef
• Class I MHC Polymorphisms Associated with Type 2 Diabetes in the Mexican Population
  Paola Mendoza-Ramírez, Mildred Alejandra López-Olaiz, Adriana Lizeth Morales-Fernández, María Isabel Flores-Echiveste, Antonio de Jesus Casillas-Navarro, Marco Andrés Pérez-Rodríguez, Felipe de Jesús Orozco-Luna, Celso Cortés-Romero, Laura Yareni Zuñiga,
  Genes.2022; 13(5): 772.     CrossRef
• Efficacy and safety of sitagliptin and insulin for latent autoimmune diabetes in adults: A systematic review and meta‐analysis
  Tong Lin, Yinhe Cai, Liting Tang, Youwei Lian, Min Liu, Chaonan Liu
  Journal of Diabetes Investigation.2022; 13(9): 1506.     CrossRef
• Partial Remission of Diabetes in a Young Adult While Testing Positive for Several Islet Cell Autoantibodies: A Case Report, Literature Review, and Patient Perspective
  Samson O Oyibo
  Cureus.2022;[Epub]     CrossRef
• Latent Autoimmune Diabetes in Adults and Metabolic Syndrome—A Mini Review
  Niansi Pan, Shimei Yang, Xiaohong Niu
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Prevalence and factors associated with latent autoimmune diabetes in adults (LADA): a cross-sectional study
  Anselmo M. Manisha, Aminiel R. Shangali, Sayoki G. Mfinanga, Erasto V. Mbugi
  BMC Endocrine Disorders.2022;[Epub]     CrossRef
• Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adults in a patient with hashitoxicosis as first presentation of Hashimoto’s thyroiditis: a case report
  Maria Xenou, Ioannis Zoupas, Dimitrios Lygnos, Evangelos Fousteris
  Journal of Medical Case Reports.2022;[Epub]     CrossRef
• Latent Autoimmune Diabetes in Adults (LADA): From Immunopathogenesis to Immunotherapy
  Jingyi Hu, Rong Zhang, Hailan Zou, Lingxiang Xie, Zhiguang Zhou, Yang Xiao
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Adult-onset autoimmune diabetes
  Raffaella Buzzetti, Ernesto Maddaloni, Jason Gaglia, R. David Leslie, F. Susan Wong, Bernhard O. Boehm
  Nature Reviews Disease Primers.2022;[Epub]     CrossRef
• Diagnostic camouflage: A case report on Latent autoimmune diabetics of adulthood
  Sandhya kiran Neupane, Prakash Paudel Jaishi, Divyaa Koirala, Arjun Kandel, Prabhat Kiran Neupane
  Annals of Medicine and Surgery.2022; 82: 104699.     CrossRef
• A Mechanistic Insight on Phytoconstituents Delivering Hypoglycemic Activity: A Comprehensive Overview
  Shraddha Singh Raghav, Bhavna Kumar, Neeraj Kumar Sethiya, Ankur Kaul
  Future Pharmacology.2022; 2(4): 511.     CrossRef
• Diagnostic Dilemmas in Young onset Diabetes Mellitus
  Avijit Saha, Parna Roy
  Annals of Medical Science & Research.2022; 1(3): 111.     CrossRef
• Prevalence of diabetes-associated autoantibodies among patients presenting with type 2 diabetes and related metabolic differences
  Fatemeh Moosaie, Neda Meftah, Niloofar Deravi, Kosar Abouhamzeh, Fatemeh Dehghani Firouzabadi, Pegah Khaloo, Mohammad Ali Mansournia, Seyede Marzie Fatemi Abhari, Manouchehr Nakhjavani, Alireza Esteghamati
  Primary Care Diabetes.2021; 15(1): 169.     CrossRef
• The association of human leukocyte antigen class II (HLA II) haplotypes with the risk of Latent autoimmune diabetes of adults (LADA): Evidence based on available data
  Wenjun Chen, Xinlin Chen, Minting Zhang, Zunnan Huang
  Gene.2021; 767: 145177.     CrossRef
• A practical approach to the clinical challenges in initiation of basal insulin therapy in people with type 2 diabetes
  Thomas Forst, Pratik Choudhary, Doron Schneider, Bruno Linetzky, Paolo Pozzilli
  Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
• Bewusstseinsstörung, Tachypnoe und Tachykardie bei einem 71-jährigen Patienten mit Diabetes mellitus Typ 2
  S. Großmann, U. Hoffmann, C. Girlich
  Der Internist.2021; 62(6): 672.     CrossRef
• Good Glycemic Outcomes Following Bariatric Surgery Among Patients With Type 2 Diabetes, Obesity, and Low-Titer GAD Antibodies
  Ruveena Kaur, David Kim, Richard Cutfield, Michael Booth, Lindsay Plank, Rinki Murphy
  Diabetes Care.2021; 44(2): 607.     CrossRef
• Slowly evolving, immune-mediated diabetes in 14-year-old patient: a case report
  M. R. Ragimov, D. D. Omelchuk, L. I. Ibragimova, O. S. Derevyanko, T. V. Nikonova
  Diabetes mellitus.2021; 24(1): 70.     CrossRef
• Combination of vitamin D and dipeptidyl peptidase-4 inhibitors (VIDPP-4i) as an immunomodulation therapy for autoimmune diabetes
  Marcelo Maia Pinheiro, Felipe Moura Maia Pinheiro, Susana Nogueira Diniz, Andrea Fabbri, Marco Infante
  International Immunopharmacology.2021; 95: 107518.     CrossRef
• Current view of diagnosis and treatment of latent autoimmune diabetes in adults
  Jana Urbanová, Ludmila Brunerová, Jana Malinovská, Barbora Pelechová, Ludmila Koberová, Jan Brož
  Vnitřní lékařství.2021; 67(2): 97.     CrossRef
• Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review
  Navjot Kaur, Vanktesh Kumar, Surendra Kumar Nayak, Pankaj Wadhwa, Paranjit Kaur, Sanjeev Kumar Sahu
  Chemical Biology & Drug Design.2021; 98(4): 539.     CrossRef
• CLINICAL AND IMMUNOLOGICAL ASPECTS OF VERIFICATION OF LATENT AUTOIMMUNE DIABETES IN ADULTS AT EARLY STAGES OF DISEASE MANIFESTATION
  Tetiana М. Tykhonova, Igor V. Belozоrov, Nadiya Ye. Barabash, Larysa O. Martymianova
  Wiadomości Lekarskie.2021; 74(7): 1707.     CrossRef
• Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: Evidence for broad based applications
  Gabriella F. Shpilsky, Hiroyuki Takahashi, Anna Aristarkhova, Michele Weil, Nathan Ng, Kacie J. Nelson, Amanda Lee, Hui Zheng, Willem M. Kühtreiber, Denise L. Faustman
  iScience.2021; 24(10): 103150.     CrossRef
• Multicentre analysis of hyperglycaemic hyperosmolar state and diabetic ketoacidosis in type 1 and type 2 diabetes
  S. R. Tittel, K. M. Sondern, M. Weyer, T. Poeplau, B. M. Sauer, M. Schebek, K.-H. Ludwig, F. Hammer, E. Fröhlich-Reiterer, R. W. Holl
  Acta Diabetologica.2020; 57(10): 1245.     CrossRef
• Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared With Type 1 Diabetes
  Anne Jörns, Dirk Wedekind, Joachim Jähne, Sigurd Lenzen
  Diabetes.2020; 69(4): 624.     CrossRef
• Past, present and future of latent autoimmune diabetes in adults
  Bingwen Liu, Yufei Xiang, Zhenqi Liu, Zhiguang Zhou
  Diabetes/Metabolism Research and Reviews.2020;[Epub]     CrossRef
• Adult-onset autoimmune diabetes in 2020: An update
  Ernesto Maddaloni, Chiara Moretti, Carmen Mignogna, Raffaella Buzzetti
  Maturitas.2020; 137: 37.     CrossRef
• Altered peripheral nerve structure and function in latent autoimmune diabetes in adults
  Tushar Issar, Aimy Yan, Natalie C. G. Kwai, Ann M. Poynten, Adeniyi A. Borire, Ria Arnold, Arun V. Krishnan
  Diabetes/Metabolism Research and Reviews.2020;[Epub]     CrossRef
• Low rate of latent autoimmune diabetes in adults (LADA) in patients followed for type 2 diabetes: A single center’s experience in Turkey
  Abbas Ali Tam, Didem Ozdemir, Nagihan Bestepe, Fatma Dilek Dellal, Muhammet Cuneyt Bilginer, Sevgul Faki, Cemile Bicer, Reyhan Ersoy, Bekir Cakir
  Archives of Endocrinology and Metabolism.2020;[Epub]     CrossRef
• Distinguishing between type 1 and type 2 diabetes
  Alexandra E Butler, David Misselbrook
  BMJ.2020; : m2998.     CrossRef
• Exogenous Insulin Injection-Induced Stiff-Person Syndrome in a Patient With Latent Autoimmune Diabetes: A Case Report and Literature Review
  Yi-Yin Lee, Cheng-Wei Lin, I-Wen Chen
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Investigating optimal β‐cell‐preserving treatment in latent autoimmune diabetes in adults: Results from a 21‐month randomized trial
  Ingrid K. Hals, Hanne Fiskvik Fleiner, Nina Reimers, Marianne C. Astor, Karin Filipsson, Zuheng Ma, Valdemar Grill, Anneli Björklund
  Diabetes, Obesity and Metabolism.2019; 21(10): 2219.     CrossRef
• Immunological and clinical characteristics of latent autoimmune diabetes in the elderly
  Silvina Yohena, Alberto Penas‐Steinhardt, Clara Muller, Natalia I. Faccinetti, Gloria E. Cerrone, Silvia Lovecchio, Edgardo Ridner, Silvina Valdez, Gustavo Frechtel
  Diabetes/Metabolism Research and Reviews.2019;[Epub]     CrossRef
• Autoimmunity in latent autoimmune diabetes in adults
  Alessandro P. Delitala
  AIMS Medical Science.2019; 6(2): 132.     CrossRef

No nationwide data have been published about thyroid hormone levels and urinary iodine concentrations (UICs) in Korea. The Korea Centers for Disease Control and Prevention and the Korean Thyroid Association established a project to evaluate the nationwide thyroid hormone profile and UICs in healthy Koreans as part of the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2013 to 2015), a nationwide, cross-sectional survey of the Korean population that enrolled 7,061 individuals who were weighted to represent the entire Korean population. Based on the KNHANES VI, the geometric mean value of serum thyroid stimulating hormone was 2.16 mIU/L, and its reference interval was 0.59 to 7.03 mIU/L. The mean value of serum free thyroxine was 1.25 ng/dL, and its reference interval was 0.92 to 1.60 ng/dL. The median UIC in the Korean population was reported to be 294 μg/L, corresponding to ‘above requirements’ iodine intake according to the World Health Organization recommendations. A U-shaped relationship of UIC with age was found. The prevalence of overt hyperthyroidism and overt hypothyroidism in the Korean population based on the KNHANES VI was 0.54% and 0.73%, respectively.

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• Correlation between shift work and non-alcoholic fatty liver disease among male workers in the steel manufacturing company of Korea: a cross-sectional study
  Kiseok Kim, Yong-Jin Lee, Soon-Chan Kwon, Young-Sun Min, Hyun Kyo Lee, Gwangin Baek, Sang Hyeon Kim, Eun-Chul Jang
  Annals of Occupational and Environmental Medicine.2022;[Epub]     CrossRef
• Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape
  Won Sang Yoo, Hyun Kyung Chung
  Endocrinology and Metabolism.2021; 36(3): 500.     CrossRef
• T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity
  Wilmar M. Wiersinga
  Endocrinology and Metabolism.2021; 36(5): 938.     CrossRef
• Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
  Jae Hoon Chung
  Endocrinology and Metabolism.2020; 35(1): 7.     CrossRef
• Different Relationships Between Thyrotropin and Muscle Strength According to Sex and Age in Euthyroid Koreans (The 6th Korea National Health and Nutritional Examination Survey 2014–2015)
  Seong Hee Ahn, Da Hea Seo, Yongin Cho, Mihye Jung, So Hun Kim, Seongbin Hong
  Thyroid.2020; 30(12): 1710.     CrossRef

Thyroid cancer has one of the highest hereditary component among human malignancies as seen in medical epidemiology investigations, suggesting the potential meaningfulness of genetic studies. Here we review researches into genetic variations that influence the chance of developing non-familial differentiated thyroid cancer (DTC), focusing on the major findings of the genome-wide association studies (GWASs) of common single-nucleotide polymorphisms (SNPs). To date, eight GWAS have been performed, and the association of a number of SNPs have been reproduced in dozens of replication investigations across different ethnicities, including Korea and Japan. Despite the cumulative effect of the strongest SNPs demonstrates gradual increase in the risk for cancer and their association signals are statistically quite significant, the overall prediction ability for DTC appears to be very limited. Thus, genotyping of common SNPs only would be insufficient for evidence-based counseling in clinical setting at present. Further studies to include less significant and rare SNPs, non-SNP genetic information, gene-gene interactions, ethnicity, non-genetic and environmental factors, and development of more advanced computational algorithms are warranted to approach to personalized disease risk prediction and prognostication.

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Citations to this article as recorded by  

• Radiation-Related Thyroid Cancer
  Vladimir Saenko, Norisato Mitsutake
  Endocrine Reviews.2024; 45(1): 1.     CrossRef
• Gene variants polymorphisms and uterine leiomyoma: an updated review
  Sonal Upadhyay, Pawan K. Dubey
  Frontiers in Genetics.2024;[Epub]     CrossRef
• The dual role of LncRNAs in hepatocellular carcinoma: Friend and foe
  Farzaneh Abam, Saeid Ghorbian
  Gastroenterology & Endoscopy.2024; 2(4): 186.     CrossRef
• Genetic and Epigenetic Association of FOXP3 with Papillary Thyroid Cancer Predisposition
  Charoula Achilla, Angeliki Chorti, Theodosios Papavramidis, Lefteris Angelis, Anthoula Chatzikyriakidou
  International Journal of Molecular Sciences.2024; 25(13): 7161.     CrossRef
• Decoding Non-coding Variants: Recent Approaches to Studying Their Role in Gene Regulation and Human Diseases
  Edwin G. Peña-Martínez, José A. Rodríguez-Martínez
  Frontiers in Bioscience-Scholar.2024;[Epub]     CrossRef
• Disease-associated non-coding variants alter NKX2-5 DNA-binding affinity
  Edwin G. Peña-Martínez, Alejandro Rivera-Madera, Diego A. Pomales-Matos, Leandro Sanabria-Alberto, Brittany M. Rosario-Cañuelas, Jessica M. Rodríguez-Ríos, Emanuel A. Carrasquillo-Dones, José A. Rodríguez-Martínez
  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.2023; 1866(1): 194906.     CrossRef
• The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update
  Robert Aurelian Tiucă, Oana Mirela Tiucă, Ionela Maria Pașcanu
  Biomedicines.2023; 11(4): 1075.     CrossRef
• Genetic susceptibility to hereditary non-medullary thyroid cancer
  Tina Kamani, Parsa Charkhchi, Afshan Zahedi, Mohammad R. Akbari
  Hereditary Cancer in Clinical Practice.2022;[Epub]     CrossRef
• Genetic signature of differentiated thyroid carcinoma susceptibility: a machine learning approach
  Giulia Brigante, Clara Lazzaretti, Elia Paradiso, Federico Nuzzo, Martina Sitti, Frank Tüttelmann, Gabriele Moretti, Roberto Silvestri, Federica Gemignani, Asta Försti, Kari Hemminki, Rossella Elisei, Cristina Romei, Eric Adriano Zizzi, Marco Agostino Der
  European Thyroid Journal.2022;[Epub]     CrossRef
• Study of single nucleotide polymorphism of vascular endothelium factor in patients with differentiated thyroid cancer
  Mohamad Mohsen Motawea, Maysaa El Sayed Zaki, Maha Saif, Asmaa Osama BS Osman, Aml Mohamed Nada
  Clinical Diabetes and Endocrinology.2022;[Epub]     CrossRef
• The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations
  Zhanna Mussazhanova, Tatiana I. Rogounovitch, Vladimir A. Saenko, Ainur Krykpayeva, Maira Espenbetova, Bauyrzhan Azizov, Hisayoshi Kondo, Katsuya Matsuda, Zhanna Kalmatayeva, Raushan Issayeva, Zhanar Yeleubayeva, Madina Madiyeva, Aray Mukanova, Marat Sand
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Incidence of the CHEK2 Germline Mutation and Its Impact on Clinicopathological Features, Treatment Responses, and Disease Course in Patients with Papillary Thyroid Carcinoma
  Danuta Gąsior-Perczak, Artur Kowalik, Krzysztof Gruszczyński, Agnieszka Walczyk, Monika Siołek, Iwona Pałyga, Sławomir Trepka, Estera Mikina, Tomasz Trybek, Janusz Kopczyński, Agnieszka Suligowska, Rafał Ślusarczyk, Agnieszka Gonet, Jarosław Jaskulski, Pa
  Cancers.2021; 13(3): 470.     CrossRef
• Carcinoma diferenciado de tiroides familiar: más allá de las formas sindrómicas
  Aida Orois, Mireia Mora, Irene Halperin, Josep Oriola
  Endocrinología, Diabetes y Nutrición.2021; 68(4): 260.     CrossRef
• Gene network and biological pathways associated with susceptibility to differentiated thyroid carcinoma
  Om Kulkarni, Pierre-Emmanuel Sugier, Julie Guibon, Anne Boland-Augé, Christine Lonjou, Delphine Bacq-Daian, Robert Olaso, Carole Rubino, Vincent Souchard, Frédérique Rachedi, Juan Jesus Lence-Anta, Rosa Maria Ortiz, Constance Xhaard, Pierre Laurent-Puig,
  Scientific Reports.2021;[Epub]     CrossRef
• Familial non medullary thyroid carcinoma: Beyond the syndromic forms
  Aida Orois, Mireia Mora, Irene Halperin, Josep Oriola
  Endocrinología, Diabetes y Nutrición (English ed.).2021; 68(4): 260.     CrossRef
• Discrimination between 34 of 36 Possible Combinations of Three C>T SNP Genotypes in the MGMT Promoter by High Resolution Melting Analysis Coupled with Pyrosequencing Using A Single Primer Set
  Katja Zappe, Christine Pirker, Heidi Miedl, Martin Schreiber, Petra Heffeter, Georg Pfeiler, Stefan Hacker, Werner Haslik, Sabine Spiegl-Kreinecker, Margit Cichna-Markl
  International Journal of Molecular Sciences.2021; 22(22): 12527.     CrossRef
• Emerging Biomarkers in Thyroid Practice and Research
  Shipra Agarwal, Andrey Bychkov, Chan-Kwon Jung
  Cancers.2021; 14(1): 204.     CrossRef
• The effects of the genetic polymorphisms of antioxidant enzymes on susceptibility to papillary thyroid carcinoma
  Saeedeh Salimi, Mahdiyeh Harati‐Sadegh, Moein Eskandari, Zahra Heidari
  IUBMB Life.2020; 72(5): 1045.     CrossRef
• Familial Aggregation and Heritability of Nonmedullary Thyroid Cancer in an Asian Population: A Nationwide Cohort Study
  Huan-Tang Lin, Fu-Chao Liu, Shu-Fu Lin, Chang-Fu Kuo, Yu-Ying Chen, Huang-Ping Yu
  The Journal of Clinical Endocrinology & Metabolism.2020; 105(7): e2521.     CrossRef
• Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?
  Kinga Hińcza, Artur Kowalik, Iwona Pałyga, Agnieszka Walczyk, Danuta Gąsior-Perczak, Estera Mikina, Tomasz Trybek, Monika Szymonek, Klaudia Gadawska-Juszczyk, Klaudia Zajkowska, Agnieszka Suligowska, Artur Kuchareczko, Karol Krawczyk, Janusz Kopczyński, M
  Cancers.2020; 12(2): 423.     CrossRef
• The effect of TP53 and P21 gene polymorphisms on papillary thyroid carcinoma susceptibility and clinical/pathological features
  Zahra Heidari, Mahdiyeh Harati‐Sadegh, Abtin Arian, Rostam Maruei‐Milan, Saeedeh Salimi
  IUBMB Life.2020; 72(5): 922.     CrossRef
• Feasibility Study Shows Multicenter, Observational Case-Control Study Is Practicable to Determine Risk of Secondary Breast Cancer in Females With Differentiated Thyroid Carcinoma Given Radioiodine Therapy in Their Childhood or Adolescence; Findings Also S
  Valentina Drozd, Rita Schneider, Tamara Platonova, Galina Panasiuk, Tatjana Leonova, Nataliya Oculevich, Irina Shimanskaja, Irina Vershenya, Tatjana Dedovich, Tatjana Mitjukova, Inge Grelle, Johannes Biko, Christoph Reiners
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer
  Fabíola Yukiko Miasaki, Cesar Seigi Fuziwara, Gisah Amaral de Carvalho, Edna Teruko Kimura
  Genes.2020; 11(11): 1364.     CrossRef
• Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer
  Kinga Hińcza, Artur Kowalik, Aldona Kowalska
  Genes.2019; 10(7): 482.     CrossRef
• Thyroid Cancer: The Quest for Genetic Susceptibility Involving DNA Repair Genes
  Luís S. Santos, Bruno Costa Gomes, Hélder N. Bastos, Octávia M. Gil, Ana Paula Azevedo, Teresa C. Ferreira, Edward Limbert, Susana N. Silva, José Rueff
  Genes.2019; 10(8): 586.     CrossRef
• Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population
  Mikhlid Almutairi, Abdullah Mohammad Alhadeq, Rafa Almeer, Mohammed Almutairi, Mohammed Alzahrani, Abdelhabib Semlali
  Molecular Genetics & Genomic Medicine.2019;[Epub]     CrossRef
• Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer
  Isabel S. Carvalho, Catarina I. Gonçalves, Joana T. Almeida, Teresa Azevedo, Teresa Martins, Fernando J. Rodrigues, Manuel C. Lemos
  Genes.2019; 10(8): 572.     CrossRef
• Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid
  Meruyert Massabayeva, Nailya Chaizhunusova, Nurlan Aukenov, Tolkyn Bulegenov, Bakytbek Apsalikov, Aigerim Shapihanova, Yersin Zhunussov
  Molecular Medicine.2019;[Epub]     CrossRef
• BRAF‐positive multifocal and unifocal papillary thyroid cancer show different messenger RNA expressions
  Kyoungjune Pak, Sunghwan Suh, Tae Sik Goh, Seong‐Jang Kim, Sae‐Ock Oh, Ju Won Seok, In Joo Kim, Yun Hak Kim
  Clinical Endocrinology.2019; 90(4): 601.     CrossRef

Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to have high heritability. Family and twin studies have indicated that genetics plays a major role in the development of thyroid diseases. Thyroid function, represented by thyroid stimulating hormone (TSH) and free thyroxine (T4), is also known to be partly genetically determined. Before the era of genome-wide association studies (GWAS), the ability to identify genes responsible for susceptibility to thyroid disease was limited. Over the past decade, GWAS have been used to identify genes involved in many complex diseases, including various phenotypes of the thyroid gland. In GWAS of autoimmune thyroid diseases, many susceptibility loci associated with autoimmunity (human leukocyte antigen [HLA], protein tyrosine phosphatase, non-receptor type 22 [PTPN22], cytotoxic T-lymphocyte associated protein 4 [CTLA4], and interleukin 2 receptor subunit alpha [IL2RA]) or thyroid-specific genes (thyroid stimulating hormone receptor [TSHR] and forkhead box E1 [FOXE1]) have been identified. Regarding thyroid function, many susceptibility loci for levels of TSH and free T4 have been identified through genome-wide analyses. In GWAS of differentiated thyroid cancer, associations at FOXE1, MAP3K12 binding inhibitory protein 1 (MBIP)-NK2 homeobox 1 (NKX2-1), disrupted in renal carcinoma 3 (DIRC3), neuregulin 1 (NRG1), and pecanex-like 2 (PCNXL2) have been commonly identified in people of European and Korean ancestry, and many other susceptibility loci have been found in specific populations. Through GWAS of various thyroid-related phenotypes, many susceptibility loci have been found, providing insights into the pathogenesis of thyroid diseases and disease co-clustering within families and individuals.

Citations

Citations to this article as recorded by  

• A new, all‐encompassing aetiology of type 1 diabetes
  Piet C. de Groen
  Immunology.2024; 171(1): 77.     CrossRef
• The role of primary cilia in thyroid diseases
  Zijiao Tian, Xinlin Li, Xue Yu, Shuxin Yan, Jingwei Sun, Wenxin Ma, Xiaoyun Zhu, Yang Tang
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Investigating the Association of Polygenic Risk Scores With Thyroid Cancer Susceptibility in a Han Chinese Population
  Yi-Hao Chen, I Chieh Chen, Chia-Man Chou, Sheng-Yang Huang
  Journal of the Endocrine Society.2024;[Epub]     CrossRef
• Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis
  Zhiwei Yao, Fengli Guo, Yanlu Tan, Yiyuan Zhang, Yichen Geng, Guang Yang, Song Wang
  Frontiers in Immunology.2024;[Epub]     CrossRef
• Association of autoimmune thyroid disease with type 1 diabetes mellitus and its ultrasonic diagnosis and management
  Jin Wang, Ke Wan, Xin Chang, Rui-Feng Mao
  World Journal of Diabetes.2024; 15(3): 348.     CrossRef
• Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer
  Xianhui Ruan, Yu Liu, Shuping Wu, Guiming Fu, Mei Tao, Yue Huang, Dapeng Li, Songfeng Wei, Ming Gao, Shicheng Guo, Junya Ning, Xiangqian Zheng
  Aging.2024;[Epub]     CrossRef
• A deep learning framework for predicting disease-gene associations with functional modules and graph augmentation
  Xianghu Jia, Weiwen Luo, Jiaqi Li, Jieqi Xing, Hongjie Sun, Shunyao Wu, Xiaoquan Su
  BMC Bioinformatics.2024;[Epub]     CrossRef
• Genome-Wide Admixture and Association Study of Serum Selenium Deficiency to Identify Genetic Variants Indirectly Linked to Selenium Regulation in Brazilian Adults
  Ligia Moriguchi Watanabe, Lisete Sousa, Francisco M. Couto, Natália Yumi Noronha, Marcela Augusta de Souza Pinhel, Gleyson Francisco da Silva Carvalho, Guilherme da Silva Rodrigues, Carlos Roberto Bueno Júnior, Leslie Domenici Kulikowski, Fernando Barbosa
  Nutrients.2024; 16(11): 1627.     CrossRef
• Unraveling susceptibility genes: A contemporary overview of autoimmune thyroid diseases
  Wenxin Zhang, Rong Ding, Yuelin Hu, Wenwen Wei, Dan Tian, Nalin Qin, Hongsong Yu, Xin Wang
  International Immunopharmacology.2024; 136: 112313.     CrossRef
• Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease
  Saedis Saevarsdottir, Kristbjörg Bjarnadottir, Thorsteinn Markusson, Jonas Berglund, Thorunn A. Olafsdottir, Gisli H. Halldorsson, Gudrun Rutsdottir, Kristbjorg Gunnarsdottir, Asgeir Orn Arnthorsson, Sigrun H. Lund, Lilja Stefansdottir, Julius Gudmundsson
  Nature Communications.2024;[Epub]     CrossRef
• Trio-based exome sequencing and high-resolution HLA typing in families of patients with autoimmune adrenal insufficiency and autoimmune polyglandular syndrome
  Anastasiia Buianova, Marina Yukina, Valery Cheranev, Oleg Suchalko, Anna Shmitko, Alina Samitova, Nurana Nuralieva, Elena Kulagina, Elena Savvateeva, Ekaterina Troshina, Denis Rebrikov, Dmitry Gryadunov, Dmitriy Korostin, Ramalingam Bethunaickan
  PLOS ONE.2024; 19(10): e0312335.     CrossRef
• Exome sequencing to explore the possibility of predicting genetic susceptibility to the joint occurrence of polycystic ovary syndrome and Hashimoto’s thyroiditis
  Natalia Zeber-Lubecka, Katarzyna Suchta, Maria Kulecka, Anna Kluska, Magdalena Piątkowska, Michal J. Dabrowski, Katarzyna Jankowska, Monika Grymowicz, Roman Smolarczyk, Ewa E. Hennig
  Frontiers in Immunology.2023;[Epub]     CrossRef
• Molecular Mechanisms in Autoimmune Thyroid Disease
  Hernando Vargas-Uricoechea
  Cells.2023; 12(6): 918.     CrossRef
• Identification of multiple novel susceptibility genes associated with autoimmune thyroid disease
  Xueying Liu, Yahu Miao, Chao Liu, Wan Lu, Qing Feng, Qiu Zhang
  Frontiers in Immunology.2023;[Epub]     CrossRef
• Novel Susceptibility Genes Drive Familial Non-Medullary Thyroid Cancer in a Large Consanguineous Kindred
  Pierre Majdalani, Uri Yoel, Tayseer Nasasra, Merav Fraenkel, Alon Haim, Neta Loewenthal, Raz Zarivach, Eli Hershkovitz, Ruti Parvari
  International Journal of Molecular Sciences.2023; 24(9): 8233.     CrossRef
• An Optimized Flow Cytometric Method to Demonstrate the Differentiation Stage-Dependent Ca2+ Flux Responses of Peripheral Human B Cells
  Anna Bajnok, Timea Serény-Litvai, Viktória Temesfői, Jasper Nörenberg, Róbert Herczeg, Ambrus Kaposi, Timea Berki, Emese Mezosi
  International Journal of Molecular Sciences.2023; 24(10): 9107.     CrossRef
• FOXE1 Contributes to the Development of Psoriasis by Regulating WNT5A
  Meng Liu, Guanfei Zhang, Ziyang Wang, Xinyi Liu, Ke He, Ruiting Luo, Qiqi Duan, Ruimin Bai, Yuqian Wang, Wenqian Du, Yan Zheng, Yongping Shao
  Journal of Investigative Dermatology.2023; 143(12): 2366.     CrossRef
• Correlation Analysis of HHV-6A Viral Load and Anti-TPO Antibody Levels in Patients with Hashimoto’s Thyroiditis
  Noorossadat Seyyedi, Fariba Esfandiyari, Gholamreza Rafiei Dehbidi, Ali Farhadi, Farahnaz Zare, Sepide Namdari, Golrokh Bahmani, Banafsheh Rastegari, Farzaneh Zarghampoor, Abbas Behzad-Behbahani
  Future Virology.2023; 18(8): 527.     CrossRef
• Primary cell cultures for the personalized therapy in aggressive thyroid cancer of follicular origin
  Poupak Fallahi, Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Armando Patrizio, Sabrina Rosaria Paparo, Gianni Marone, Maria Rosaria Galdiero, Giovanni Guglielmi, Rudy Foddis, Alfonso Cristaudo, Alessandro Antonelli
  Seminars in Cancer Biology.2022; 79: 203.     CrossRef
• The Relationship between PTPN22 R620W Polymorphisms and the Susceptibility to Autoimmune Thyroid Diseases: An Updated Meta-analysis
  Huaiyong Wu, Siyuan Wan, Mengying Qu, Bingxuan Ren, Lixiang Liu, Hongmei Shen
  Immunological Investigations.2022; 51(2): 438.     CrossRef
• Identification of Transcriptional Pattern Related to Immune Cell Infiltration With Gene Co-Expression Network in Papillary Thyroid Cancer
  Meiye Li, Jimei Zhang, Zongjing Zhang, Ying Qian, Wei Qu, Zhaoshun Jiang, Baochang Zhao
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
  Sean J. Jurgens, Seung Hoan Choi, Valerie N. Morrill, Mark Chaffin, James P. Pirruccello, Jennifer L. Halford, Lu-Chen Weng, Victor Nauffal, Carolina Roselli, Amelia W. Hall, Matthew T. Oetjens, Braxton Lagerman, David P. vanMaanen, Goncalo Abecasis, Xiao
  Nature Genetics.2022; 54(3): 240.     CrossRef
• Factors affecting recurrence in subacute granulomatous thyroiditis
  Çiğdem Tura Bahadir, Merve Yilmaz, Elif Kiliçkan
  Archives of Endocrinology and Metabolism.2022;[Epub]     CrossRef
• Shared etiology of type 1 diabetes and Hashimoto’s thyroiditis: a population-based twin study
  Jakob Skov, Ralf Kuja-Halkola, Patrik K E Magnusson, Soffia Gudbjörnsdottir, Olle Kämpe, Sophie Bensing
  European Journal of Endocrinology.2022; 186(6): 677.     CrossRef
• High Prevalence of Common Human Viruses in Thyroid Tissue
  Therese Weider, Angelo Genoni, Francesco Broccolo, Trond H. Paulsen, Knut Dahl-Jørgensen, Antonio Toniolo, Sara Salehi Hammerstad
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• B cells from anti-thyroid antibody positive, infertile women show hyper-reactivity to BCR stimulation
  Timea Serény-Litvai, Anna Bajnok, Viktoria Temesfoi, Jasper Nörenberg, Greta Pham-Dobor, Ambrus Kaposi, Akos Varnagy, Kalman Kovacs, Sandor Pentek, Tamas Koszegi, Emese Mezosi, Timea Berki
  Frontiers in Immunology.2022;[Epub]     CrossRef
• Pathogenesis Markers of Hashimoto's Disease—A Mini Review
  Binghui Jin, Shuang Wang, Zhe Fan
  Frontiers in Bioscience-Landmark.2022;[Epub]     CrossRef
• What do the structures of GCN5-containing complexes teach us about their function?
  Dominique Helmlinger, Gábor Papai, Didier Devys, László Tora
  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.2021; 1864(2): 194614.     CrossRef
• Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto’s Thyroiditis: How Far Is Our Understanding?
  Natalia Zeber-Lubecka, Ewa E. Hennig
  Frontiers in Immunology.2021;[Epub]     CrossRef
• Type 1 Diabetes and Autoimmune Thyroid Disease—The Genetic Link
  Lara Frommer, George J. Kahaly
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Familial Risk of Hashimoto's Thyroiditis Among First-Degree Relatives: A Population-Based Study in Korea
  Hyun Jung Kim, Sayada Zartasha Kazmi, Taeuk Kang, Seo Young Sohn, Dong-Sook Kim, Hoo Jae Hann, Hyeong Sik Ahn
  Thyroid.2021; 31(7): 1096.     CrossRef
• Limited Genetic Overlap Between Overt Hashimoto’s Thyroiditis and Graves’ Disease in Twins: A Population-based Study
  Jakob Skov, Jan Calissendorff, Daniel Eriksson, Patrik Magnusson, Olle Kämpe, Sophie Bensing, Ralf Kuja-Halkola
  The Journal of Clinical Endocrinology & Metabolism.2021; 106(4): e1101.     CrossRef
• Endogenous and Synthetic Regulators of the Peripheral Components of the Hypothalamo-Hypophyseal-Gonadal and -Thyroid Axes
  A. O. Shpakov
  Neuroscience and Behavioral Physiology.2021; 51(3): 332.     CrossRef
• Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves’ Disease and Hashimoto’s Thyroiditis in Korean Patients
  Jee Hee Yoon, Min-ho Shin, Hee Nam Kim, Wonsuk Choi, Ji Yong Park, A Ram Hong, Hee Kyung Kim, Ho-Cheol Kang
  Endocrinology and Metabolism.2021; 36(3): 599.     CrossRef
• Predisposition to Graves’ disease and Graves’ ophthalmopathy by genetic variants of IL2RA
  Juan Du, Xin Wang, Guiqin Tan, Wenwen Wei, Fangyu Zhou, Zhongzhi Liang, Hua Li, Hongsong Yu
  Journal of Molecular Medicine.2021; 99(10): 1487.     CrossRef
• Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population
  Zahra Heidari, Saeedeh Salimi, Mohsen Rokni, Mahnaz Rezaei, Neshat Khalafi, Mahdieh Jafari Shahroudi, Azizallah Dehghan, Mohsen Saravani, Rafael S. De Molon
  BioMed Research International.2021; 2021: 1.     CrossRef
• Genetic Polymorphisms in the PCNXL2 Gene are Risk Factors for Thyroid Cancer in the Chinese Population
  Runmei Hao, Peng Han, Ling Zhang, Ying Bi, Jinfeng Yan, Honghui Li, Yanxia Bai, Chongwen Xu, Baiya Li, Huajing Li
  Future Oncology.2021; 17(34): 4677.     CrossRef
• Genetic Variants Associated with Thyroid Cancer Risk: Comprehensive Research Synopsis, Meta-Analysis, and Cumulative Epidemiological Evidence
  Ran Ran, Gang Tu, Hui Li, Hao Wang, Exian Mou, Caiyang Liu, Yuan Seng Wu
  Journal of Oncology.2021; 2021: 1.     CrossRef
• The Identification of Three Key Genes Related to Stemness in Thyroid Carcinoma through Comprehensive Analysis
  Tonglong Zhang, Chunhong Yan, Zhengdu Ye, Xingling Yin, Tian-an Jiang
  Combinatorial Chemistry & High Throughput Screening.2021; 24(3): 423.     CrossRef
• Епідеміологія автоімунного тиреоїдиту
  V.I. Кravchenko, О.А. Тоvkay, О.V. Rakov, М.D. Тronko
  INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2021; 17(2): 136.     CrossRef
• The Prevalence Role of Monocyte Chemoattractant Protein-1 in Hashimoto's Thyroiditis via Various Stimuli Mechanisms
  Israa Burhan Raoof, Raghad Abdulmahdi Mohsin, Zahraa Ahmed Okhti
  Journal of Pharmacy and Bioallied Sciences.2021; 13(2): 244.     CrossRef
• Thyroid autoimmune disorders and cancer
  Silvia Martina Ferrari, Poupak Fallahi, Giusy Elia, Francesca Ragusa, Ilaria Ruffilli, Sabrina Rosaria Paparo, Alessandro Antonelli
  Seminars in Cancer Biology.2020; 64: 135.     CrossRef
• Association of FCRL3 rs7528684 polymorphism with risk of Hashimoto's thyroiditis in Iranian patients
  Kurosh Kalantar, Farzad Ghandehari, Saeed Malek-Hosseini, Hossein Golmoghaddam, Davood Rostamzadeh, Mohamad Hossein Dabbaghmanesh, Zahra Amirghofran
  Meta Gene.2020; 24: 100663.     CrossRef
• Differentiated thyroid cancer and Hashimoto thyroiditis: Utility of the Afirma gene expression classifier
  Vardan Papoian, Jennifer E. Rosen, Wen Lee, Leonard Wartofsky, Erin A. Felger
  Journal of Surgical Oncology.2020; 121(7): 1053.     CrossRef
• Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden
  Hauke Thomsen, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki
  Journal of Translational Autoimmunity.2020; 3: 100058.     CrossRef
• Association of rs944289, rs965513, and rs1443434 in TITF1/TITF2 with Risks of Papillary Thyroid Carcinoma and with Nodular Goiter in Northern Chinese Han Populations
  Xin Zhang, Yulu Gu, Yong Li, Heran Cui, Xiaoli Liu, Hui Sun, Qiong Yu, Yaqin Yu, Yawen Liu, Siyan Zhan, Yi Cheng
  International Journal of Endocrinology.2020; 2020: 1.     CrossRef
• FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease
  Saedis Saevarsdottir, Thorunn A. Olafsdottir, Erna V. Ivarsdottir, Gisli H. Halldorsson, Kristbjorg Gunnarsdottir, Asgeir Sigurdsson, Ari Johannesson, Jon K. Sigurdsson, Thorhildur Juliusdottir, Sigrun H. Lund, Asgeir O. Arnthorsson, Edda L. Styrmisdottir
  Nature.2020; 584(7822): 619.     CrossRef
• Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis
  Ohoud Subhi, Hans-Juergen Schulten, Nadia Bagatian, Roa'a Al-Dayini, Sajjad Karim, Sherin Bakhashab, Reem Alotibi, Alaa Al-Ahmadi, Manar Ata, Aisha Elaimi, Saad Al-Muhayawi, Majid Mansouri, Khalid Al-Ghamdi, Osman Abdel Hamour, Awatif Jamal, Jaudah Al-Mag
  PLOS ONE.2020; 15(6): e0234566.     CrossRef
• Thyroid cancer and thyroid autoimmune disease: A review of molecular aspects and clinical outcomes
  Natália Medeiros Dias Lopes, Hannah Hamada Mendonça Lens, André Armani, Poliana Camila Marinello, Alessandra Lourenço Cecchini
  Pathology - Research and Practice.2020; 216(9): 153098.     CrossRef
• Immune gene signature delineates a subclass of thyroid cancer with unfavorable clinical outcomes
  Jingtai Zhi, Jiaoyu Yi, Mengran Tian, Huijuan Wang, Ning Kang, Xiangqian Zheng, Ming Gao
  Aging.2020; 12(7): 5733.     CrossRef
• VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER
  Yu. I. Karachentsev, V. M. Dubovik, I. V. Gopkalova, V. V. Khaziev, S. S. Sokolova, Y. P. Korchagin, N. G. Filonenko, M. Y. Sazonov, L. V. Gerasimenko
  Bulletin of Problems Biology and Medicine.2020; 3(1): 105.     CrossRef
• Analysis of Polymorphisms rs7093069-IL-2RA, rs7138803-FAIM2, and rs1748033-PADI4 in the Group of Adolescents With Autoimmune Thyroid Diseases
  Beata Sawicka, Hanna Borysewicz-Sańczyk, Natalia Wawrusiewicz-Kurylonek, Tommaso Aversa, Domenico Corica, Joanna Gościk, Adam Krętowski, Małgorzata Waśniewska, Artur Bossowski
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Familial associations for rheumatoid autoimmune diseases
  Hauke Thomsen, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki
  Rheumatology Advances in Practice.2020;[Epub]     CrossRef
• Familial risks between giant cell arteritis and Takayasu arteritis and other autoimmune diseases in the population of Sweden
  Hauke Thomsen, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki
  Scientific Reports.2020;[Epub]     CrossRef
• The Association of Obesity with Autoimmune Thyroiditis and Thyroid Function-Possible Mechanisms of Bilateral Interaction
  Agnieszka Baranowska-Bik, Wojciech Bik, Henrik Falhammar
  International Journal of Endocrinology.2020; 2020: 1.     CrossRef
• The Risk of Recurrence of Subacute Thyroiditis Is HLA-Dependent
  Magdalena Stasiak, Bogusław Tymoniuk, Bartłomiej Stasiak, Andrzej Lewiński
  International Journal of Molecular Sciences.2019; 20(5): 1089.     CrossRef
• FOXE1 inhibits cell proliferation, migration and invasion of papillary thyroid cancer by regulating PDGFA
  Zheng Ding, Ronghu Ke, Yong Zhang, Youben Fan, Jianxia Fan
  Molecular and Cellular Endocrinology.2019; 493: 110420.     CrossRef
• Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer
  Kinga Hińcza, Artur Kowalik, Aldona Kowalska
  Genes.2019; 10(7): 482.     CrossRef
• Thyroid Cancer: The Quest for Genetic Susceptibility Involving DNA Repair Genes
  Luís S. Santos, Bruno Costa Gomes, Hélder N. Bastos, Octávia M. Gil, Ana Paula Azevedo, Teresa C. Ferreira, Edward Limbert, Susana N. Silva, José Rueff
  Genes.2019; 10(8): 586.     CrossRef
• Genetic Polymorphisms on 4q21.1 Contributed to the Risk of Hashimoto's Thyroiditis
  Dachao Mo, Junjiu Li, Liang Peng, Zhiyuan Liu, Jieyun Wang, Jiru Yuan
  Genetic Testing and Molecular Biomarkers.2019; 23(12): 837.     CrossRef
• A Weighted Genetic Risk Score Using Known Susceptibility Variants to Predict Graves Disease Risk
  Yu-Ru Ma, Shuang-Xia Zhao, Lu Li, Feng Sun, Xiao-Ping Ye, Fei-Fei Yuan, Dan Jiang, Zheng Zhou, Qian-Yue Zhang, Yue-Yue Wan, Guang-Ya Zhang, Jing Wu, Rui-Jia Zhang, Ya Fang, Huai-Dong Song
  The Journal of Clinical Endocrinology & Metabolism.2019; 104(6): 2121.     CrossRef
• Architects meets Repairers: The interplay between homeobox genes and DNA repair
  Bruno César Feltes
  DNA Repair.2019; 73: 34.     CrossRef
• Development of a prognostic index based on an immunogenomic landscape analysis of papillary thyroid cancer
  Peng Lin, Yi-nan Guo, Lin Shi, Xiao-jiao Li, Hong Yang, Yun He, Qing Li, Yi-wu Dang, Kang-lai Wei, Gang Chen
  Aging.2019; 11(2): 480.     CrossRef
• Selenium and Selenoproteins in Immune Mediated Thyroid Disorders
  Liliana R. Santos, Celestino Neves, Miguel Melo, Paula Soares
  Diagnostics.2018; 8(4): 70.     CrossRef
• Sex-specific genetic influence on thyroid-stimulating hormone and free thyroxine levels, and interactions between measurements: KNHANES 2013–2015
  Young Ki Lee, Dong Yeob Shin, Hyejung Shin, Eun Jig Lee, Silvia Naitza
  PLOS ONE.2018; 13(11): e0207446.     CrossRef

The incidence of thyroid cancer has increased, mainly due to the incidental finding of low-risk papillary thyroid cancers (PTC). These malignancies grow slowly, and are unlikely to cause morbidity and mortality. New understanding about the prognosis of tumor features has led to reclassification of many tumors within the low-risk thyroid category, and to the development of a new one “very low-risk tumors.” Alternative less aggressive approaches to therapy are now available including active surveillance and minimally invasive interventions. In this narrative review, we have summarized the available evidence for the management of low-risk PTC.

Citations

Citations to this article as recorded by  

• Risk of malignancy in Thy3 thyroid nodules
  Emad Mofid Nassif Rezkallah, Ragai Sobhi Hanna, Wael Magdy Elsaify
  Endocrine Regulations.2024; 58(1): 19.     CrossRef
• Adequacy of clinical guideline recommendations for patients with low-risk cancer managed with monitoring: systematic review
  Kiana K. Collins, Claire Friedemann Smith, Tori Ford, Nia Roberts, Brian D. Nicholson, Jason L. Oke
  Journal of Clinical Epidemiology.2024; 169: 111280.     CrossRef
• Endokrine Onkologie
  Kerstin Lorenz
  Die Innere Medizin.2024; 65(7): 656.     CrossRef
• Racial–Ethnic Comparison of Treatment for Papillary Thyroid Cancer in the Military Health System
  Yvonne L. Eaglehouse, Sarah Darmon, Craig D. Shriver, Kangmin Zhu
  Annals of Surgical Oncology.2024; 31(12): 8196.     CrossRef
• A Qualitative Thematic Analysis Exploring Chinese Young Adults’ Experiences in Decision Making on the Management of Low-Risk Papillary Thyroid Cancer
  Xinyue Gu, Pingting Zhu, Hui Zhang, Wen Wang, Yinwen Ding, Meiyan Qian, Guanghui Shi, Qianqian Zhang, Josephine Hegarty
  Thyroid®.2024;[Epub]     CrossRef
• Safety and Effectiveness of Percutaneous Ethanol Injection as a Treatment for Locally Recurrent Papillary Thyroid Carcinoma
  Amin Momeni Moghaddam, Mahsa Abbaszadeh, Vajihe Chavoshi, Amir Ebadinejad, Nafiseh Hassanloo, Farhad Hosseinpanah
  International Journal of Endocrinology and Metabolism.2024;[Epub]     CrossRef
• Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer
  Eduardo Cararo Lopes, Akshada Sawant, Dirk Moore, Hua Ke, Fuqian Shi, Saurabh Laddha, Ying Chen, Anchal Sharma, Jake Naumann, Jessie Yanxiang Guo, Maria Gomez, Maria Ibrahim, Tracey L. Smith, Gregory M. Riedlinger, Edmund C. Lattime, Stanley Trooskin, Shr
  Clinical and Translational Medicine.2023;[Epub]     CrossRef
• Clinical management of low-risk papillary thyroid microcarcinoma
  Chie MASAKI, Kiminori SUGINO, Koichi ITO
  Minerva Endocrinology.2022;[Epub]     CrossRef
• The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant behaviors of papillary thyroid carcinoma cells
  Chong Zhang, Huxia Gu, Dingrong Liu, Fuyun Tong, Huijie Wei, Dan Zhou, Jing Fang, Xiaolu Dai, Haibo Tian
  Molecular and Cellular Biochemistry.2022; 477(11): 2627.     CrossRef
• An Appraisal and Update of Fluorodeoxyglucose and Non-Fluorodeoxyglucose-PET Tracers in Thyroid and Non–Thyroid Endocrine Neoplasms
  Aadil Adnan, Shobhana Raju, Rakesh Kumar, Sandip Basu
  PET Clinics.2022; 17(3): 343.     CrossRef
• A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess
  David D. Dolidze, Alexey V. Shabunin, Robert B. Mumladze, Arshak V. Vardanyan, Serghei D. Covantsev, Alexander M. Shulutko, Vasiliy I. Semikov, Khalid M. Isaev, Airazat M. Kazaryan
  Frontiers in Oncology.2022;[Epub]     CrossRef
• Ethanol Ablation as a Treatment in a Low-Risk Follicular Thyroid Cancer: A Case Report
  Juan Pesantez, Carla Lituma, Carla Valencia, Jose Prieto, Marco Cazorla
  Cureus.2022;[Epub]     CrossRef
• The new T3b category has clinical significance? SEER‐based study
  Jingzhe Xiang, Zhihong Wang, Wei Sun, Hao Zhang
  Clinical Endocrinology.2021; 94(3): 449.     CrossRef
• Efficacy and Safety of Thermal Ablation for Solitary T1bN0M0 Papillary Thyroid Carcinoma: A Multicenter Study
  Xiao-Jing Cao, Juan Liu, Ya-Lin Zhu, Lu Qi, Geng Liu, Hong-Ling Wang, Zhong-Hua Wang, Ying Zhou, Jun-Feng He, Jian-Qin Guo, Li-Li Shi, Mei Jian, Aini Shataer, Guo-Zhen Yan, Zhen-Long Zhao, Ying Wei, Li-Li Peng, Yan Li, Ying Che, Shu-Rong Wang, Ming-An Yu
  The Journal of Clinical Endocrinology & Metabolism.2021; 106(2): e573.     CrossRef
• A Clinical Audit of Hemithyroidectomy for Differentiated Thyroid Cancer—Experience from a Tertiary Cancer Center
  Nithyanand Chidambaranathan, Shivakumar Thiagarajan, Nandini Menon, Adhara Chakraborthy, Richa Vaish, Devendra Chaukar
  Indian Journal of Surgery.2021; 83(6): 1444.     CrossRef
• Pros and cons of hemi‐thyroidectomy for low‐risk differentiated thyroid cancer
  Alexander J. Papachristos, Anthony Glover, Mark S. Sywak, Stan B. Sidhu
  ANZ Journal of Surgery.2021; 91(9): 1704.     CrossRef
• Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer
  Eun Jeong Ban, Daham Kim, Jin Kyong Kim, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Kunhong Kim
  Endocrinology and Metabolism.2021; 36(1): 96.     CrossRef
• Taraxasterol inhibits TGF-β1-induced epithelial-to-mesenchymal transition in papillary thyroid cancer cells through regulating the Wnt/β-catenin signaling
  J Zhu, X Li, S Zhang, J Liu, X Yao, Q Zhao, B Kou, P Han, X Wang, Y Bai, Z Zheng, C Xu
  Human & Experimental Toxicology.2021; 40(12_suppl): S87.     CrossRef
• Is Delayed Papillary Thyroid Cancer Surgery Associated with Higher Mortality Risk?
  Eddy P. Lincango Naranjo, Juan P. Brito
  Clinical Thyroidology.2021; 33(9): 400.     CrossRef
• MicroRNA-99a-3p/GRP94 axis affects metastatic progression of human papillary thyroid carcinoma by regulating ITGA2 expression and localization
  Yun Gao, Yi Pan, Tingting Wang, Ying Yao, Wenbo Yuan, Xue Zhu, Ke Wang
  Acta Biochimica et Biophysica Sinica.2021; 53(12): 1650.     CrossRef
• Microscopic Extrathyroidal Extension Results in Increased Rate of Tumor Recurrence and Is an Independent Predictor of Patient’s Outcome in Middle Eastern Papillary Thyroid Carcinoma
  Sandeep Kumar Parvathareddy, Abdul K. Siraj, Zeeshan Qadri, Felisa DeVera, Khawar Siddiqui, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
  Frontiers in Oncology.2021;[Epub]     CrossRef
• 80MAP17 promotes the tumorigenesis of papillary thyroid carcinoma by reducing the stability of p53
  Kun Yu, Hongjiang Lu, Yanhong Chen, Ying Xin, Zhuo Tan, Qiong Yang
  Frontiers in Bioscience-Landmark.2021;[Epub]     CrossRef
• New paradigms in the treatment of low-risk thyroid cancer
  Firas Baidoun, Anas M. Saad, Omar Abdel-Rahman
  Expert Review of Endocrinology & Metabolism.2020; 15(4): 251.     CrossRef
• The Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy
  Magdalena Rudzińska, Barbara Czarnocka
  International Journal of Molecular Sciences.2020; 21(9): 3220.     CrossRef
• Modified risk stratification based on cervical lymph node metastases following lobectomy for papillary thyroid carcinoma
  Eyun Song, Jonghwa Ahn, Dong Eun Song, Won Woong Kim, Min Ji Jeon, Tae‐Yon Sung, Tae Yong Kim, Ki Wook Chung, Won Bae Kim, Young Kee Shong, Suck Joon Hong, Yu‐Mi Lee, Won Gu Kim
  Clinical Endocrinology.2020; 92(4): 358.     CrossRef
• Clinicopathological significance of the single nucleotide polymorphism, rs2853669 within the TERT promoter in papillary thyroid carcinoma
  Tatsuya Hirokawa, Yuu Arimasu, Tomohiro Chiba, Masachika Fujiwara, Hiroshi Kamma
  Pathology International.2020; 70(4): 217.     CrossRef
• Diagnostic accuracy and ability to reduce unnecessary FNAC: A comparison between four Thyroid Imaging Reporting Data System (TI-RADS) versions
  Lingsze Tan, Ying Sern Tan, Suzet Tan
  Clinical Imaging.2020; 65: 133.     CrossRef
• Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer
  Keisuke Enomoto, Muneki Hotomi
  Endocrinology and Metabolism.2020; 35(2): 227.     CrossRef
• FDG PET/CT versus somatostatin receptor PET/CT in TENIS syndrome: a systematic review and meta-analysis
  Felipe Alves Mourato, Maria Amorim Almeida, Ana Emília Teixeira Brito, Aline Lopes Garcia Leal, Paulo Almeida Filho, Elba Etchebehere
  Clinical and Translational Imaging.2020; 8(5): 365.     CrossRef
• Factors Associated with Health Behaviors in Thyroid Cancer Survivors
  Junghyun Yoon, Boyoung Park
  Journal of Cancer Prevention.2020; 25(3): 173.     CrossRef
• Patient-Derived Papillary Thyroid Cancer Organoids for Radioactive Iodine Refractory Screening
  Luc H.J. Sondorp, Vivian M.L. Ogundipe, Andries H. Groen, Wendy Kelder, Annelies Kemper, Thera P. Links, Robert P. Coppes, Schelto Kruijff
  Cancers.2020; 12(11): 3212.     CrossRef
• Hemithyroidectomy for Thyroid Cancer: A Review
  Noor Addasi, Abbey Fingeret, Whitney Goldner
  Medicina.2020; 56(11): 586.     CrossRef
• Clinical Outcomes after Early and Delayed Radioiodine Remnant Ablation in Patients with Low-Risk Papillary Thyroid Carcinoma: Propensity Score Matching Analysis
  Jonghwa Ahn, Meihua Jin, Eyun Song, Min Ji Jeon, Tae Yong Kim, Jin-Sook Ryu, Won Bae Kim, Young Kee Shong, Ji Min Han, Won Gu Kim
  Endocrinology and Metabolism.2020; 35(4): 830.     CrossRef
• Clinical Significance of Gross Invasion of Strap Muscles in Patients With 1- to 4-cm-Sized Papillary Thyroid Carcinoma Undergoing Lobectomy
  Eyun Song, Won Woong Kim, Min Ji Jeon, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Ki Wook Chung, Won Bae Kim, Young Kee Shong, Suck Joon Hong, Yu-Mi Lee, Won Gu Kim
  Annals of Surgical Oncology.2019; 26(13): 4466.     CrossRef
• Lobectomy Is Feasible for 1–4 cm Papillary Thyroid Carcinomas: A 10-Year Propensity Score Matched-Pair Analysis on Recurrence
  Eyun Song, Minkyu Han, Hye-Seon Oh, Won Woong Kim, Min Ji Jeon, Yu-Mi Lee, Tae Yong Kim, Ki Wook Chung, Won Bae Kim, Young Kee Shong, Suck Joon Hong, Tae-Yon Sung, Won Gu Kim
  Thyroid.2019; 29(1): 64.     CrossRef
• Laser and radiofrequency ablations for benign and malignant thyroid tumors
  Giovanni Mauri, Nicolò Gennaro, Min Kyoung Lee, Jung Hwan Baek
  International Journal of Hyperthermia.2019; 36(2): 13.     CrossRef
• US-Guided Radiofrequency Ablation for Low-Risk Papillary Thyroid Microcarcinoma: Efficacy and Safety in a Large Population
  Hyun Kyung Lim, Se Jin Cho, Jung Hwan Baek, Kang Dae Lee, Chang Woo Son, Jung Min Son, Seon Mi Baek
  Korean Journal of Radiology.2019; 20(12): 1653.     CrossRef
• Utility of Early Postoperative Unstimulated Thyroglobulin in Influencing Decision Making in Patients with Papillary Thyroid Carcinoma
  Alexandria D. McDow, Cynthia M. Shumway, Susan C. Pitt, David F. Schneider, Rebecca S. Sippel, Kristin L. Long
  Annals of Surgical Oncology.2019; 26(12): 4002.     CrossRef
• Extent of Surgery for Low-Risk Differentiated Thyroid Cancer
  Alexandria D. McDow, Susan C. Pitt
  Surgical Clinics of North America.2019; 99(4): 599.     CrossRef

Citations

Citations to this article as recorded by  

• Endocrinology and Metabolism Has Been Indexed in MEDLINE: A Major Achievement
  Won-Young Lee
  Endocrinology and Metabolism.2019; 34(2): 138.     CrossRef
• Being Indexed in SCIE: A Major Step Forward for Endocrinology and Metabolism
  Won-Young Lee
  Endocrinology and Metabolism.2019; 34(3): 263.     CrossRef

Citations

Citations to this article as recorded by  

• Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells
  Tomoko Kaketaka, Ikuo Mineo, Yu Kimura, Naohiko Ito, Yukiyoshi Okauchi, Hiromi Tamura, Shiro Adachi, Hiromi Iwahashi
  Internal Medicine.2024; 63(10): 1415.     CrossRef
• Diagnostic Performance of Preoperative Calcitonin and Procalcitonin Tests for Differential Diagnosis of Medullary Thyroid Cancer
  Il Youb Jeong, Hyeok Jun Yun, Seok-Mo Kim, Yongjung Park
  Diagnostics.2024; 14(16): 1809.     CrossRef
• [111In]In-CP04 as a novel cholecystokinin-2 receptor ligand with theranostic potential in patients with progressive or metastatic medullary thyroid cancer: final results of a GRAN-T-MTC Phase I clinical trial
  Luka Lezaic, Paola Anna Erba, Clemens Decristoforo, Katja Zaletel, Renata Mikolajczak, Helmut Maecke, Theodosia Maina, Mark Konijnenberg, Petra Kolenc, Malgorzata Trofimiuk-Müldner, Elwira Przybylik-Mazurek, Irene Virgolini, Marion de Jong, Alide C Fröber
  European Journal of Nuclear Medicine and Molecular Imaging.2023; 50(3): 892.     CrossRef
• Diagnostic tests for medullary thyroid carcinoma: an umbrella review
  Pierpaolo Trimboli, Caterina Mian, Arnoldo Piccardo, Giorgio Treglia
  Endocrine.2023; 81(2): 183.     CrossRef
• Advances in Diagnostics and Therapy of Medullary Thyroid Carcinoma (MTC)– A Mini-Review
  Michał Miciak, Krzysztof Jurkiewicz
  Clinical Cancer Investigation Journal.2023; 12(5): 1.     CrossRef
• Role of Polypeptide Inflammatory Biomarkers in the Diagnosis and Monitoring of COVID-19
  Aparajita Sen, Arti Nigam, Meenakshi Vachher
  International Journal of Peptide Research and Therapeutics.2022;[Epub]     CrossRef
• A pregnancy-specific reference interval for procalcitonin
  Samuel Dockree, Jennifer Brook, Tim James, Brian Shine, Manu Vatish
  Clinica Chimica Acta.2021; 513: 13.     CrossRef
• Clinical performance of calcitonin and procalcitonin Elecsys® immunoassays in patients with medullary thyroid carcinoma
  Luca Giovanella, Martina Fontana, Franco Keller, Frederik A. Verburg, Luca Ceriani
  Clinical Chemistry and Laboratory Medicine (CCLM).2021; 59(4): 743.     CrossRef
• Correlation between preoperative ultrasonic features of medullary thyroid carcinoma and postoperative recurrence
  Qiaodan Zhu, Dong Xu
  BMC Cancer.2021;[Epub]     CrossRef
• Calcitonin and complementary biomarkers in the diagnosis of hereditary medullary thyroid carcinoma in children and adolescents
  Felix Eckelt, Roland Pfaeffle, Wieland Kiess, Juergen Kratzsch
  Journal of Pediatric Endocrinology and Metabolism.2021; 34(12): 1491.     CrossRef
• Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis
  Marisa A. Bartz-Kurycki, Omowunmi E. Oluwo, Lilah F. Morris-Wiseman
  Therapeutic Advances in Endocrinology and Metabolism.2021;[Epub]     CrossRef
• Diagnostic Challenges of Medullary Thyroid Carcinoma
  Robert D. Leimbach, Thanh D. Hoang, Mohamed K.M. Shakir
  Oncology.2021; 99(7): 422.     CrossRef
• The Diagnostic and Antibiotic Reference Values of Procalcitonin for Intracranial Infection After Craniotomy
  Lei Zhu, Lun Dong, Yuping Li, Guangyu Lu, Hengzhu Zhang, Xingdong Wang, Xiaoguang Liu, Zhenfei Teng, Boming Xia, Peng Zhang
  World Neurosurgery.2019; 126: e1.     CrossRef
• Triennial Report ofEndocrinology and Metabolism, 2015 to 2017
  Eun-Jung Rhee, Hey Yeon Jang, Won-Young Lee
  Endocrinology and Metabolism.2018; 33(2): 195.     CrossRef

Citations

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• Association between urinary albumin creatinine ratio and cardiovascular disease
  Yoo Jin Kim, Sang Won Hwang, Taesic Lee, Jun Young Lee, Young Uh, Gulali Aktas
  PLOS ONE.2023; 18(3): e0283083.     CrossRef
• Association between urine albumin to creatinine ratio and bone mineral density: a cross-sectional study
  Kemal Sherefa Oumer, Yawen Liu, Tesfaye Getachew Charkos, Shuman Yang
  Irish Journal of Medical Science (1971 -).2022; 191(1): 427.     CrossRef
• Association between perfluoroalkyl substances concentration and bone mineral density in the US adolescents aged 12-19 years in NHANES 2005-2010
  Xianmei Xiong, Baihang Chen, Zhongqing Wang, Liqiong Ma, Shijie Li, Yijia Gao
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Mood and Metabolic Health Status of Elderly Osteoporotic Patients in Korea: A Cross-Sectional Study of a Nationally Representative Sample
  Hyen Chul Jo, Gu-Hee Jung, Seong-Ho Ok, Ji Eun Park, Jong Chul Baek
  Healthcare.2021; 9(1): 77.     CrossRef

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• Multifunctional nanoparticle-mediated combining therapy for human diseases
  Xiaotong Li, Xiuju Peng, Makhloufi Zoulikha, George Frimpong Boafo, Kosheli Thapa Magar, Yanmin Ju, Wei He
  Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
• Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
  Ji Hye Han, Kyong Hye Joung, Jun Choul Lee, Ok Soon Kim, Sorim Choung, Ji Min Kim, Yea Eun Kang, Hyon-Seung Yi, Ju Hee Lee, Bon Jeong Ku, Hyun Jin Kim
  Diabetes & Metabolism Journal.2024; 48(1): 112.     CrossRef
• Combining Ezetimibe and Rosuvastatin: Impacts on Insulin Sensitivity and Vascular Inflammation in Patients with Type 2 Diabetes Mellitus
  Eun Roh
  Diabetes & Metabolism Journal.2024; 48(1): 55.     CrossRef
• Does Rosuvastatin/Ezetimibe Combination Therapy Offer Potential Benefits for Glucose Metabolism beyond Lipid-Lowering Efficacy in T2DM?
  Il Rae Park, Jun Sung Moon
  Diabetes & Metabolism Journal.2024; 48(3): 387.     CrossRef
• 2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
  Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang
  Diabetes & Metabolism Journal.2024; 48(4): 546.     CrossRef
• Efficacy and Safety of Pitavastatin/Ezetimibe Fixed-Dose Combination vs. Pitavastatin: Phase III, Double-Blind, Randomized Controlled Trial
  Kenichi Tsujita, Koutaro Yokote, Junya Ako, Ryohei Tanigawa, Sachiko Tajima, Hideki Suganami
  Journal of Atherosclerosis and Thrombosis.2023; 30(11): 1580.     CrossRef
• 2023 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
  Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Nan Hee Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, YoonJu Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Youl Rhee, Hae J
  Diabetes & Metabolism Journal.2023; 47(5): 575.     CrossRef
• Ezetimibe combination therapy with statin for non-alcoholic fatty liver disease: an open-label randomized controlled trial (ESSENTIAL study)
  Yongin Cho, Hyungjin Rhee, Young-eun Kim, Minyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jin-Young Choi, Yong-ho Lee
  BMC Medicine.2022;[Epub]     CrossRef
• RSSDI consensus recommendations for dyslipidemia management in diabetes mellitus
  Banshi Saboo, Sanjay Agarwal, Brij Mohan Makkar, Rajeev Chawla, Sujoy Ghosh, Vijay Viswanathan, Sunil Gupta, Ch. Vasanth Kumar, Anuj Maheshwari, L. Sreenivasamurthy, Rakesh Kumar Sahay, Sanjay Reddy, Shalini Jaggi, Jugal Kishor Sharma, Vijay Panikar, Anan
  International Journal of Diabetes in Developing Countries.2022; 42(1): 3.     CrossRef
• Ezetimibe and diabetes mellitus:a new strategy for lowering cholesterol
  V.A. Serhiyenko, A.A. Serhiyenko
  INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2022; 18(5): 302.     CrossRef
• 2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
  Kyu Yeon Hur, Min Kyong Moon, Jong Suk Park, Soo-Kyung Kim, Seung-Hwan Lee, Jae-Seung Yun, Jong Ha Baek, Junghyun Noh, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Ye Seul Yang, Jang Won Son, Jong Han Choi, Kee Ho Song, Nam Hoon Kim, Sang Yong Kim, Jin Wha Kim,
  Diabetes & Metabolism Journal.2021; 45(4): 461.     CrossRef
• Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity-Matched Nationwide Cohort Study
  You-Bin Lee, Bongsung Kim, Kyungdo Han, Jung A Kim, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
  Journal of Lipid and Atherosclerosis.2021; 10(3): 303.     CrossRef
• PCSK9 inhibitors and cardiovascular outcomes
  Daniel Steffens, Peter Bramlage, Céline Scheeff, Mario Kasner, Adel Hassanein, Julian Friebel, Ursula Rauch-Kröhnert
  Expert Opinion on Biological Therapy.2020; 20(1): 35.     CrossRef
• Comparison of Renal Effects of Ezetimibe–Statin Combination versus Statin Monotherapy: A Propensity-Score-Matched Analysis
  Jaehyun Bae, Namki Hong, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Yong-ho Lee
  Journal of Clinical Medicine.2020; 9(3): 798.     CrossRef
• Effect of Ezetimibe on Glucose Metabolism and Inflammatory Markers in Adipose Tissue
  Yongin Cho, Ryeong-Hyeon Kim, Hyunki Park, Hye Jin Wang, Hyangkyu Lee, Eun Seok Kang
  Biomedicines.2020; 8(11): 512.     CrossRef
• Future perspectives of the pharmacological management of diabetic dyslipidemia
  Angelo Maria Patti, Rosaria Vincenza Giglio, Nikolaos Papanas, Manfredi Rizzo, Ali A. Rizvi
  Expert Review of Clinical Pharmacology.2019; 12(2): 129.     CrossRef
• Diabetes and Vascular Disease: Is It All About Glycemia?
  Alessandra Vecchié, Fabrizio Montecucco, Federico Carbone, Franco Dallegri, Aldo Bonaventura
  Current Pharmaceutical Design.2019; 25(29): 3112.     CrossRef
• Triennial Report ofEndocrinology and Metabolism, 2015 to 2017
  Eun-Jung Rhee, Hey Yeon Jang, Won-Young Lee
  Endocrinology and Metabolism.2018; 33(2): 195.     CrossRef
• Guidelines, Clinical Evidence, and Real-Life Practice: How to Find Your Way in Managing Hypercholesterolaemia
  Janet Fricker
  EMJ Cardiology.2018; : 38.     CrossRef

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• Prognostic value of star-shaped intense uptake of 131I in thyroid cancer patients
  Liu Xiao, Wen Jie Zhang, Yue Qi Wang, Lin Li
  Revista Española de Medicina Nuclear e Imagen Molecular (English Edition).2021; 40(1): 30.     CrossRef
• Valores pronósticos de la captación en estrella de 131I en pacientes con cáncer diferenciado de tiroides
  L. Xiao, W.J. Zhang, Y.Q. Wang, L. Li
  Revista Española de Medicina Nuclear e Imagen Molecular.2021; 40(1): 30.     CrossRef
• Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
  Yusuke Iizuka, Tomohiro Katagiri, Minoru Inoue, Kiyonao Nakamura, Takashi Mizowaki
  Scientific Reports.2021;[Epub]     CrossRef

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• Utility of right adrenal signature veins in venous sampling for primary aldosteronism
  Zhenglin Shen, Shaoyong Xu, Siyu Guan, Bo Chen, Qingan Li, Ming Yu, Zhao Gao
  Annals of Medicine.2023;[Epub]     CrossRef
• Key to the Treatment of Primary Aldosteronism in Secondary Hypertension: Subtype Diagnosis
  Rui Zuo, Shuang Liu, Lu Xu, Hua Pang
  Current Hypertension Reports.2023; 25(12): 471.     CrossRef
• A clinical assessment of portable point-of-care testing for quick cortisol assay during adrenal vein sampling
  Ko Aiga, Mitsuhiro Kometani, Shigehiro Karashima, Seigo Konishi, Takuya Higashitani, Daisuke Aono, Xurong Mai, Mikiya Usukura, Takahiro Asano, Ayako Wakayama, Yuko Noda, Wataru Koda, Tetsuya Minami, Satoshi Kobayashi, Toshinori Murayama, Takashi Yoneda
  Scientific Reports.2023;[Epub]     CrossRef
• Does Intraprocedural CT Improve the Success Rate of Adrenal Venous Sampling? A Systematic Review and Meta-Analysis of Data from 809 Patients
  Nima Hafezi-Nejad, David M. Gullotti, Christopher R. Bailey, Mark L. Lessne, Brian P. Holly
  CardioVascular and Interventional Radiology.2022; 45(1): 29.     CrossRef
• Prevalence and clinical characteristics of primary aldosteronism in a tertiary-care center in Korea
  Minjae Yoon, Namki Hong, Jaehyung Ha, Chan Joo Lee, Cheol Ryong Ku, Yumie Rhee, Sungha Park
  Hypertension Research.2022; 45(9): 1418.     CrossRef
• Cone-beam computed tomography is not a mandatory procedure in adrenal venous sampling for primary hyperaldosteronism
  Ran Cai, Chao Hu, Hai-Yang Li
  BMC Medical Imaging.2022;[Epub]     CrossRef
• Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism
  Mitsuhide Naruse, Akiyo Tanabe, Koichi Yamamoto, Hiromi Rakugi, Mitsuhiro Kometani, Takashi Yoneda, Hiroki Kobayashi, Masanori Abe, Youichi Ohno, Nobuya Inagaki, Shoichiro Izawa, Masakatsu Sone
  Endocrinology and Metabolism.2021; 36(5): 965.     CrossRef
• Controversies and advances in adrenal venous sampling in the diagnostic workup of primary aldosteronism
  Martin Wolley, Moe Thuzar, Michael Stowasser
  Best Practice & Research Clinical Endocrinology & Metabolism.2020; 34(3): 101400.     CrossRef
• Update on the Aldosterone Resolution Score and Lateralization in Patients with Primary Aldosteronism
  Eun-Hee Cho
  Endocrinology and Metabolism.2018; 33(3): 352.     CrossRef

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• Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma
  Satoshi Narahara, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Yoki Furuta, Kentaro Tanaka, Takayuki Tokunaga, Takeshi Kawasaki, Yoko Yoshimaru, Hiroko Setoyama, Kentaro Oniki, Junji Saruwatari, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Ya
  Hepatology Communications.2022; 6(5): 1198.     CrossRef
• The role of circadian rhythm in choroid plexus functions
  Telma Quintela, André Furtado, Ana C. Duarte, Isabel Gonçalves, Jihwan Myung, Cecília R.A. Santos
  Progress in Neurobiology.2021; 205: 102129.     CrossRef
• A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury
  Drew Watson, Joshua Y. C. Yang, Reuben D. Sarwal, Tara K. Sigdel, Juliane M. Liberto, Izabella Damm, Victoria Louie, Shristi Sigdel, Devon Livingstone, Katherine Soh, Arjun Chakraborty, Michael Liang, Pei-Chen Lin, Minnie M. Sarwal
  Journal of Clinical Medicine.2019; 8(4): 499.     CrossRef

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• A novel heterozygous mutation in PTHLH causing autosomal dominant brachydactyly type E complicated with short stature
  Jian Sun, Nian Yang, Zhengquan Xu, Hongbo Cheng, Xiangxin Zhang
  Molecular Genetics & Genomic Medicine.2024;[Epub]     CrossRef
• A novel mutation in PTHLH in a family with a variable phenotype with brachydactyly, short stature, oligodontia and developmental delay
  Mirjam E.A. Scheffer-Rath, Hermine E. Veenstra-Knol, Annemieke M. Boot
  Bone Reports.2023; 19: 101699.     CrossRef
• Bioactive phytoconstituents as potent inhibitors of casein kinase-2: dual implications in cancer and COVID-19 therapeutics
  Farah Anjum, Md Nayab Sulaimani, Alaa Shafie, Taj Mohammad, Ghulam Md. Ashraf, Anwar L. Bilgrami, Fahad A. Alhumaydhi, Suliman A. Alsagaby, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
  RSC Advances.2022; 12(13): 7872.     CrossRef
• Characterization and expression profiling of G protein-coupled receptors (GPCRs) in Spodoptera litura (Lepidoptera: Noctuidae)
  Yanxiao Li, Han Gao, Hui Zhang, Runnan Yu, Fan Feng, Jing Tang, Bin Li
  Comparative Biochemistry and Physiology Part D: Genomics and Proteomics.2022; 44: 101018.     CrossRef
• Genes with specificity for expression in the round cell layer of the growth plate are enriched in genomewide association study (GWAS) of human height
  Nora E. Renthal, Priyanka Nakka, John M. Baronas, Henry M. Kronenberg, Joel N. Hirschhorn
  Journal of Bone and Mineral Research.2020; 36(12): 2300.     CrossRef
• Search for Novel Mutational Targets in Human Endocrine Diseases
  So Young Park, Myeong Han Seo, Sihoon Lee
  Endocrinology and Metabolism.2019; 34(1): 23.     CrossRef
• A Heterozygous Splice-Site Mutation in PTHLH Causes Autosomal Dominant Shortening of Metacarpals and Metatarsals
  Monica Reyes, Bert Bravenboer, Harald Jüppner
  Journal of Bone and Mineral Research.2019; 34(3): 482.     CrossRef
• A 3.06-Mb interstitial deletion on 12p11.22-12.1 caused brachydactyly type E combined with pectus carinatum
  Jia Huang, Hong-Yan Liu, Rong-Rong Wang, Hai Xiao, Dong Wu, Tao Li, Ying-Hai Jiang, Xue Zhang
  Chinese Medical Journal.2019; 132(14): 1681.     CrossRef
• Parathyroid Hormone-Related Protein in the Hand or Out of Hand?
  Sang Wan Kim
  Endocrinology and Metabolism.2018; 33(2): 202.     CrossRef