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Volume 34(4); December 2019
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Review Articles
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Intraoperative Parathyroid Hormone Monitoring in the Surgical Management of Sporadic Primary Hyperparathyroidism
Zahra F. Khan, John I. Lew
Endocrinol Metab. 2019;34(4):327-339.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.327
  • 5,550 View
  • 123 Download
  • 23 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   ePub   

Intraoperative parathyroid hormone monitoring (IPM) has been shown to be a useful adjunct during parathyroidectomy to ensure operative success at many specialized medical centers worldwide. Using the Miami or “>50% intraoperative PTH drop” criterion, IPM confirms the complete excision of all hyperfunctioning parathyroid tissue before the operation is finished, and helps guide the surgeon to identify additional hyperfunctioning parathyroid glands that may necessitate further extensive neck exploration when intraoperative parathyroid hormone (PTH) levels do not drop sufficiently. The intraoperative PTH assay is also used to differentiate parathyroid from non-parathyroid tissues during operations using fine needle aspiration samples and to lateralize the side of the neck harboring the hypersecreting parathyroid through differential jugular venous sampling when preoperative localization studies are negative or equivocal. The use of IPM underscores the recognition and understanding of sporadic primary hyperparathyroidism (SPHPT) as a disease of function rather than form, where the surgeon is better equipped to treat such patients with quantitative instead of qualitative information for durable long-term operative success. There has been a significant paradigm shift over the last 2 decades from conventional to focused parathyroidectomy guided by IPM. This approach has proven to be a safe and rapid operation requiring minimal dissection performed in an ambulatory setting for the treatment of SPHPT.

Citations

Citations to this article as recorded by  
  • Intraoperative parathyroid hormone monitoring in parathyroidectomy for hyperparathyroidism: a protocol for a network meta-analysis of diagnostic test accuracy
    Phillip Staibano, Kevin Um, Sheila Yu, Mohit Bhandari, Michael K. Gupta, Michael Au, JEM (Ted) Young, Han Zhang
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  • Magnitude of parathyroid hormone elevation in primary hyperparathyroidism: Does time of day matter?
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  • Analysis of intraoperative laboratory measurements and imaging techniques such as Tc-99 m-MIBI SPECT/CT, 18F-fluorocholine PET/CT and ultrasound in patients operated with prediagnosis of parathyroid adenoma
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  • Intraoperative Parathyroid Hormone Monitoring Is of Limited Usefulness in Guiding Autotransplantation in Reoperative or Subtotal Parathyroidectomy for Primary Hyperparathyroidism
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  • A >50% Intraoperative Parathyroid Hormone Decrease Into Normal Reference Range Predicts Complete Excision of Malignancy in Patients With Parathyroid Carcinoma
    Valerie L. Armstrong, Tanaz M. Vaghaiwalla, Cima Saghira, Cheng-Bang Chen, Yujie Wang, Johan Anantharaj, Mehmet Ackin, John I. Lew
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    Klaas Van Den Heede, Amélie Bonheure, Nele Brusselaers, Sam Van Slycke
    Langenbeck's Archives of Surgery.2022; 407(7): 3045.     CrossRef
  • Contribution of intraoperative parathyroid hormone monitoring to the surgical success in minimal invasive parathyroidectomy
    Ismail Ethem Akgün, Mehmet Taner Ünlü, Nurcihan Aygun, Mehmet Kostek, Mehmet Uludag
    Frontiers in Surgery.2022;[Epub]     CrossRef
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    Murilo Catafesta das Neves, Rodrigo Oliveira Santos, Monique Nakayama Ohe
    Archives of Endocrinology and Metabolism.2022; 66(5): 678.     CrossRef
  • Використання інтраопераційного моніторингу рівня паратиреоїдного гормону в мінімально інвазивній хірургії щитоподібної та паращитоподібних залоз
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  • Diagnostic Values of Intraoperative (1-84) Parathyroid Hormone Levels are Superior to Intact Parathyroid Hormone for Successful Parathyroidectomy in Patients With Chronic Kidney Disease
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  • Delayed Calcium Normalization after Successful Parathyroidectomy in Primary Hyperparathyroidism
    Iván Emilio de la Cruz Rodríguez, Elsy Sarahí García Montesinos, María Fernanda Rodríguez-Delgado, Guadalupe Vargas Ortega, Lourdes Balcázar Hernández, Victoria Mendoza Zubieta, Victor Hernández Avendaño, Baldomero González Virla, Micha�l R. Laurent
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  • Parathyroid Surgery
    Aditya S. Shirali, Uriel Clemente-Gutierrez, Nancy D. Perrier
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  • Focused parathyroidectomy without intraoperative parathyroid hormone measurement in primary hyperparathyroidism: Still a valid approach?
    Shelby Holt
    Surgery.2021; 170(6): 1860.     CrossRef
  • Response to the Comment on “Risk Factors of Redo Surgery After Unilateral Focused Parathyroidectomy – Conclusions From a Comprehensive Nationwide Database of 13,247 Interventions Over 6 Years”
    Robert Caiazzo, Camille Marciniak, Francois Pattou
    Annals of Surgery.2021; 274(6): e861.     CrossRef
Close layer
Thyroid
Bisphenols and Thyroid Hormone
Min Joo Kim, Young Joo Park
Endocrinol Metab. 2019;34(4):340-348.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.340
  • 9,326 View
  • 237 Download
  • 61 Web of Science
  • 64 Crossref
AbstractAbstract PDFPubReader   ePub   

In recent decades, attention has been directed toward the effects of bisphenol A (BPA) on human health. BPA has estrogenic activity and is regarded as a representative endocrine disruptor. In addition, mounting evidence indicates that BPA can disrupt thyroid hormone and its action. This review examined human epidemiological studies to investigate the association between BPA exposure and thyroid hormone levels, and analyzed in vivo and in vitro experiments to identify the causal relationship and its mechanism of action. BPA is involved in thyroid hormone action not only as a thyroid hormone receptor antagonist, but also through several other mechanisms. Since the use of bisphenols other than BPA has recently increased, we also reviewed the effects of other bisphenols on thyroid hormone action.

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  • BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells
    Kristen G. Harnett, Ashley Chin, Sonya M. Schuh
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  • Bisphenols and the Development of Type 2 Diabetes: The Role of the Skeletal Muscle and Adipose Tissue
    Fozia Ahmed, Maria Pereira, Céline Aguer
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    Gabriella Schiera, Carlo Maria Di Liegro, Italia Di Liegro
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Close layer
Miscellaneous
Medical Big Data Is Not Yet Available: Why We Need Realism Rather than Exaggeration
Hun-Sung Kim, Dai-Jin Kim, Kun-Ho Yoon
Endocrinol Metab. 2019;34(4):349-354.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.349
  • 5,928 View
  • 140 Download
  • 36 Web of Science
  • 48 Crossref
AbstractAbstract PDFPubReader   ePub   

Most people are now familiar with the concepts of big data, deep learning, machine learning, and artificial intelligence (AI) and have a vague expectation that AI using medical big data can be used to improve the quality of medical care. However, the expectation that big data could change the field of medicine is inconsistent with the current reality. The clinical meaningfulness of the results of research using medical big data needs to be examined. Medical staff needs to be clear about the purpose of AI that utilizes medical big data and to focus on the quality of this data, rather than the quantity. Further, medical professionals should understand the necessary precautions for using medical big data, as well as its advantages. No doubt that someday, medical big data will play an essential role in healthcare; however, at present, it seems too early to actively use it in clinical practice. The field continues to work toward developing medical big data and making it appropriate for healthcare. Researchers should continue to engage in empirical research to ensure that appropriate processes are in place to empirically evaluate the results of its use in healthcare.

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Close layer
Adrenal gland
Molecular Mechanisms of Primary Aldosteronism
Sergei G. Tevosian, Shawna C. Fox, Hans K. Ghayee
Endocrinol Metab. 2019;34(4):355-366.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.355
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  • 144 Download
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AbstractAbstract PDFPubReader   ePub   

Primary aldosteronism (PA) results from excess production of mineralocorticoid hormone aldosterone by the adrenal cortex. It is normally caused either by unilateral aldosterone-producing adenoma (APA) or by bilateral aldosterone excess as a result of bilateral adrenal hyperplasia. PA is the most common cause of secondary hypertension and associated morbidity and mortality. While most cases of PA are sporadic, an important insight into this debilitating disease has been derived through investigating the familial forms of the disease that affect only a minor fraction of PA patients. The advent of gene expression profiling has shed light on the genes and intracellular signaling pathways that may play a role in the pathogenesis of these tumors. The genetic basis for several forms of familial PA has been uncovered in recent years although the list is likely to expand. Recently, the work from several laboratories provided evidence for the involvement of mammalian target of rapamycin pathway and inflammatory cytokines in APAs; however, their mechanism of action in tumor development and pathophysiology remains to be understood.

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Close layer
Original Articles
Clinical Study
Impact of Subtotal Parathyroidectomy on Clinical Parameters and Quality of Life in Hemodialysis Patients with Secondary Hyperparathyroidism
Mohamed Mimi Abd Elgawwad El-kholey, Ghada El-said Ibrahim, Osama Ibrahim Elshahat, Ghada El-Kannishy
Endocrinol Metab. 2019;34(4):367-373.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.367
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  • 81 Download
  • 3 Web of Science
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AbstractAbstract PDFPubReader   ePub   
Background

Impairment of quality of life (QOL) is a key clinical characteristic of patients with end-stage renal disease (ESRD), and can be especially severe in the presence of secondary hyperparathyroidism (SHPT). Despite the proven success of parathyroidectomy (PTX) in controlling biochemical parameters in patients with severe SHPT, evidence is lacking regarding the effects of PTX on various clinical outcomes, including QOL.

Methods

Twenty ESRD patients on maintenance hemodialysis with SHPT who underwent subtotal PTX were included in an observational longitudinal study. All studied patients underwent history-taking, clinical examinations, and laboratory investigations, including a complete blood count and measurements of serum calcium, phosphorus, magnesium, parathyroid hormone (PTH), and albumin levels preoperatively and at 3 months postoperatively. QOL was assessed before surgery and at 3 months after surgery using the Kidney Disease Quality of Life 36-Item Short-Form instrument.

Results

After PTX, significant decreases in serum PTH and phosphorus levels were observed, as well as a significant increase in serum magnesium levels. Significant weight gain and improvements of QOL were also detected postoperatively.

Conclusion

Subtotal PTX seems to be an efficient alternative to medical management in uncontrolled cases of SHPT, as it is capable of controlling the biochemical derangements that occur in hyperparathyroidism. Furthermore, PTX had a beneficial effect on clinical outcomes, as shown by weight gain and improvements in all QOL scales.

Citations

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  • Abnormalities of serum magnesium levels in dialysis patients undergoing parathyroidectomy
    Chi-Yu Kuo, Chung-Hsin Tsai, Jie-Jen Lee, Shih-Ping Cheng
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Close layer
Clinical Study
The Modified Ferriman-Gallwey Score and Hirsutism among Filipino Women
Ma. Karen Celine C. Ilagan, Elizabeth Paz-Pacheco, Darwin Z. Totesora, Lyra Ruth Clemente-Chua, Jundelle Romulo K. Jalique
Endocrinol Metab. 2019;34(4):374-381.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.374
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  • 175 Download
  • 18 Web of Science
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AbstractAbstract PDFPubReader   ePub   
Background

The modified Ferriman-Gallwey (mFG) score is the gold standard for the clinical evaluation of hirsutism. However, racial variations in terminal hair growth limit this tool. This study aimed to determine the mFG cut-off score among Filipino women and its association with biochemical hyperandrogenism.

Methods

A total of 128 Filipino women were included in this prospective cross-sectional study and were divided into two groups: a polycystic ovary syndrome (PCOS) group (n=28) and a non-PCOS group (n=100). The participants underwent mFG score determination, ovarian ultrasound conducted by a single sonographer, and hormone testing. The mFG cut-off score was determined based on the 95th percentile of the non-PCOS group. Logistic regression was used to analyze the relationship between mFG score and biochemical hyperandrogenism.

Results

Although the mFG score was generally low in both the PCOS and non-PCOS groups, the former exhibited a higher mean score than the latter (4.3±3.0 vs. 2.0±2.2, P<0.001). Normal values for the total mFG score ranged from 0 to 7. Using a cut-off score of 7, a higher proportion of hirsute women (mFG score ≥7) was observed in the PCOS group versus the non-PCOS group (17.9% vs. 5.0%, P=0.025). Elevated calculated free testosterone (FT) was also found to be significantly associated with hirsutism (odds ratio, 6.2; 95% confidence interval, 1.2 to 32.4 pmol/L; P=0.030).

Conclusion

A score of 7 and above constitutes hirsutism in this population of Filipino women. Hirsute women are more likely than non-hirsute women to have elevated calculated FT.

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    Heliyon.2021; 7(11): e08338.     CrossRef
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  • Testosterone or Dehydroepiandrosterone Sulfate as a Biomarker for Hirsutism in Women with Polycystic Ovary Syndrome
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Close layer
Clinical Study
Favorable Glycemic Control with Once-Daily Insulin Degludec/Insulin Aspart after Changing from Basal Insulin in Adults with Type 2 Diabetes
Han Na Jang, Ye Seul Yang, Seong Ok Lee, Tae Jung Oh, Bo Kyung Koo, Hye Seung Jung
Endocrinol Metab. 2019;34(4):382-389.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.382
  • 5,113 View
  • 143 Download
  • 7 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Conflicting results have been reported on the efficacy of insulin degludec/insulin aspart (IDegAsp) compared to basal insulin in type 2 diabetes. We investigated the effects of changing basal insulin to IDegAsp on glycemic control and sought to identify factors related to those effects.

Methods

In this retrospective study of patients from three referral hospitals, patients with type 2 diabetes using basal insulin with hemoglobin A1c (HbA1c) levels less than 11.0% were enrolled. Basal insulin was replaced with IDegAsp, and data were analyzed from 3 months before to 3 months after the replacement.

Results

Eighty patients were recruited (52.5% male; mean age, 67.0±9.8 years; mean duration of diabetes, 18.9±8.5 years; mean HbA1c, 8.7%±1.0%). HbA1c levels increased during 3 months of basal insulin use, but significantly decreased after changing to IDegAsp (8.28%±1.10%, P=0.0001). The reduction was significant at 6 months in 35 patients whose longer-term data were available. Patients with a measured fasting plasma glucose (m-FPG) lower than their predicted FPG (p-FPG) by regression from HbA1c showed a significant HbA1c reduction caused by the change to IDegAsp, even without a significantly increased insulin dose. However, patients whose m-FPG was higher than their p-FPG did not experience a significant HbA1c reduction, despite a significantly increased insulin dose. Furthermore, the HbA1c reduction caused by IDegAsp was significant in patients with low fasting C-peptide levels and high insulin doses.

Conclusion

We observed a significant glucose-lowering effect by replacing basal insulin with IDegAsp, especially in patients with a lower m-FPG than p-FPG.

Citations

Citations to this article as recorded by  
  • Evaluation of the efficiency of insulin degludec/insulin aspart therapy in controlling hyperglycemia and hypoglycemia in patients with type 2 diabetes mellitus: a real-life experience
    Gökçen Güngör Semiz, İsmail Selimoğlu, Mehmet Emin Arayici, Serkan Yener, Abdurrahman Çömlekçi, Tevfik Demir
    International Journal of Diabetes in Developing Countries.2023; 43(4): 544.     CrossRef
  • Low fasting glucose‐to‐estimated average glucose ratio was associated with superior response to insulin degludec/aspart compared with basal insulin in patients with type 2 diabetes
    Han Na Jang, Ye Seul Yang, Tae Jung Oh, Bo Kyung Koo, Seong Ok Lee, Kyong Soo Park, Hak Chul Jang, Hye Seung Jung
    Journal of Diabetes Investigation.2022; 13(1): 85.     CrossRef
  • Efficacy and Safety of Insulin Degludec/Insulin Aspart (IDegAsp) in Type 2 Diabetes: Systematic Review and Meta-Analysis
    Brenda C Edina, Jeremy R Tandaju, Lowilius Wiyono
    Cureus.2022;[Epub]     CrossRef
  • Comparing time to intensification between insulin degludec/insulin aspart and insulin glargine: A single-center experience from India
    Rajiv Kovil
    Journal of Diabetology.2022; 13(2): 171.     CrossRef
  • Efficacy and Safety of Insulin Degludec/Insulin Aspart Compared with a Conventional Premixed Insulin or Basal Insulin: A Meta-Analysis
    Shinje Moon, Hye-Soo Chung, Yoon-Jung Kim, Jae-Myung Yu, Woo-Ju Jeong, Jiwon Park, Chang-Myung Oh
    Metabolites.2021; 11(9): 639.     CrossRef
  • Fear of Hypoglycemia in Adults with diabetes mellitus switching to Treatment with IDegAsp Co-formulation to Examine real-world setting: an observational study (The HATICE study)
    Ulaş Serkan Topaloğlu, Hatice Kayış Topaloğlu, Melih Kızıltepe, Mesut Kılıç, Sami Bahçebaşı, Sibel Ata, Şeyma Yıldız, Yasin Şimşek
    Drug Metabolism and Drug Interactions.2021; 36(2): 129.     CrossRef
  • Response: Favorable Glycemic Control with Once-Daily Insulin Degludec/Insulin Aspart after Changing from Basal Insulin in Adults with Type 2 Diabetes (Endocrinol Metab 2019; 34:382-9, Han Na Jang et al.)
    Han Na Jang, Hye Seung Jung
    Endocrinology and Metabolism.2020; 35(1): 194.     CrossRef
  • Letter: Favorable Glycemic Control with Once-Daily Insulin Degludec/Insulin Aspart after Changing from Basal Insulin in Adults with Type 2 Diabetes (Endocrinol Metab 2019; 34:382-9, Han Na Jang et al.)
    Sang Youl Rhee
    Endocrinology and Metabolism.2020; 35(1): 192.     CrossRef
  • Fear of hypoglycemia in adults with diabetes mellitus switching to treatment with IDegAsp co-formulation to examine real-world setting: an observational study (The HATICE study)
    Ulaş Serkan Topaloğlu, Hatice Kayış Topaloğlu, Melih Kızıltepe, Mesut Kılıç, Sami Bahçebaşı, Sibel Ata, Şeyma Yıldız, Yasin Şimşek
    Drug Metabolism and Personalized Therapy.2020;[Epub]     CrossRef
Close layer
Clinical Study
Association between Serum Gamma-Glutamyltransferase and Prevalence of Metabolic Syndrome Using Data from the Korean Genome and Epidemiology Study
Mi Young Lee, Dae Sung Hyon, Ji Hye Huh, Hae Kyung Kim, Sul Ki Han, Jang Young Kim, Sang Baek Koh
Endocrinol Metab. 2019;34(4):390-397.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.390
  • 6,094 View
  • 120 Download
  • 14 Web of Science
  • 15 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

The aim of this study was to determine whether there is a positive correlation between gamma-glutamyltransferase (GGT) levels and the prevalence of metabolic syndrome and whether GGT can be used as an easily checkable metabolic index using data from the large-scale Korean Genome and Epidemiology Study (KoGES).

Methods

We obtained data of 211,725 participants of the KoGES. The collected data included age, sex, height, weight, waist circumference, and various biochemical characteristics, including serum GGT levels. The data of study participants who ingested more than 40 g/day of alcohol and who were diagnosed with metabolic syndrome at baseline was excluded. We analyzed the prevalence of metabolic syndrome according to GGT quartiles in both genders.

Results

The GGT level was significantly higher in subjects with metabolic syndrome compared to normal subjects (37.92±48.20 mg/dL vs. 25.62±33.56 mg/dL). The prevalence of metabolic syndrome showed a stepwise increase with GGT quartiles in both male and female subjects. Compared to the lowest GGT quartile, the odds ratio was 1.534 (95% confidence interval [CI], 1.432 to 1.643), 1.939 (95% CI, 1.811 to 2.076), and 2.754 (95% CI, 2.572 to 2.948) in men and 1.155 (95% CI, 1.094 to 1.218), 1.528 (95% CI, 1.451 to 1.609), and 2.022 (95% CI, 1.921 to 2.218) in women with increasing GGT quartile. The cutoff value of GGT predicting risk of metabolic syndrome was 27 IU/L in men and 17 IU/L in women.

Conclusion

We suggested that GGT could be an easily checkable marker for the prediction of metabolic syndrome.

Citations

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    Melanni L. Lizarbe-Lezama, Jhoel E. Rodriguez-Macedo, Daniel Fernandez-Guzman, Ana L. Alcantara-Diaz, Gustavo Salinas-Sedo, Carlos J. Toro-Huamanchumo
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    Rosanna Villani, Grazia Pia Magnati, Giulia Tuccari, Moris Sangineto, Antonino Davide Romano, Tommaso Cassano, Gaetano Serviddio
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    Jiwon Kwak, In-Ho Seo, Yong-Jae Lee
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    Bobbili Tarun Kesava Naidu, Kakarlapudi Santosh Raju, Janapareddi V BhaskaraRao, Nallapati Sunil Kumar
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    Elena Raya-Cano, Rafael Molina-Luque, Manuel Vaquero-Abellán, Guillermo Molina-Recio, Rocío Jiménez-Mérida, Manuel Romero-Saldaña
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    Aziz Jamal, Akira Babazono, Ning Liu, Rieko Yamao, Takako Fujita, Sung-a Kim, Yunfei Li
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    Akshay Shelar, Nalini Humaney, Akshay Chhajed, Krunal Domki, Ajay Narwade
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    Xinping Jiang, Zhang Yang, Shuai Wang, Shuanglin Deng
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    Mohammadhossein Somi, Seyed Sina Zakavi, Alireza Ostadrahimi, Negin Frounchi, Neda Gilani, Sarvin Sanaie, Elnaz Faramarzi
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    Luan Manh Chu, Chandima Karunanayake, Palok Aich, Markus Hecker, Punam Pahwa
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    Chang-Hoon Lee, Kyungdo Han, Da Hye Kim, Min-Sun Kwak
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    Eun Jung Choi, Sang Yeoup Lee
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    Wei Liu, Hui Song, Siliang Man, Hongchao Li, Siming Gao
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    Shan Tian, Jiao Li, Yingyun Guo, Weiguo Dong, Xin Zheng
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Close layer
Clinical Study
Short-Term Effects of Beraprost Sodium on the Markers for Cardiovascular Risk Prediction in Type 2 Diabetic Patients with Microalbuminuria
Yun Mi Choi, Hyuk-Sang Kwon, Kyung Mook Choi, Won-Young Lee, Eun-Gyoung Hong
Endocrinol Metab. 2019;34(4):398-405.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.398
  • 5,406 View
  • 60 Download
  • 7 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

To evaluate the changes in cardiovascular risk markers including pulse wave velocity (PWV), microalbuminuria, inflammatory cytokines, and adhesion molecules after treatment with beraprost sodium (BPS) in patients with diabetic nephropathy.

Methods

This was a multicenter, prospective, randomized, double-blind, placebo-controlled trial. Type 2 diabetes mellitus patients with microalbuminuria were included. The primary endpoints were changes in microalbuminuria in spot urine and PWV after BPS or placebo (PCB) treatment for 24 weeks. The secondary endpoints were changes in clinical and metabolic parameters.

Results

A total of 52 patients completed the 24-week trial. Changes in PWV were not different significantly in the BPS and PCB groups (right, P=0.16; left, P=0.11). Changes in microalbuminuria were 14.2±157.0 and 34.5±146.6 (µg/mg Cr) in the BPS and PCB groups, respectively (P=0.63). Subgroup analysis in the high blood pressure (BP) group (baseline systolic BP >120 mm Hg and diastolic BP >80 mm Hg), showed that microalbuminuria decreased by −47.6 in the BPS group compared with an increase by 116.4 (µg/mg Cr) in the PCB group (P=0.04). Also, in the large waist circumference group (>95 cm), microalbuminuria decreased significantly in the BPS group (P=0.04).

Conclusion

Short-term treatment of BPS for patients with diabetic nephropathy did not show significant improvement in various cardiovascular risk factors. However, BPS significantly decreased microalbuminuria in study subjects with higher cardiovascular risk such as high BP or large waist circumference.

Citations

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    Chen Sun, Xin Wu, Xin Zhang, Shulin Li, Ruoyu Jia, Dong Sun
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    Peng Yan, Ben Ke, Xiangdong Fang
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    Mengyun Xiao, Donge Tang, Shaodong Luan, Bo Hu, Wenyu Gong, Wolfgang Pommer, Yong Dai, Lianghong Yin
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    Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Kamran Hessami, Mojtaba Shabani-Borujeni, Mahnaz Hosseini-Bensenjan, Shahla Rezaei, Mohammad Jalali, Pedram Keshavarz, Fariba Ahmadizar
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    Styliani Geronikolou, Işil Takan, Athanasia Pavlopoulou, Marina Mantzourani, George Chrousos
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    Ukhti Jamil Rustiasari, Joris J. Roelofs
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    Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
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Close layer
Clinical Study
Impact of the Dynamic Change of Metabolic Health Status on the Incident Type 2 Diabetes: A Nationwide Population-Based Cohort Study
Jung A Kim, Da Hye Kim, Seon Mee Kim, Yong Gyu Park, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Kyungdo Han, Hye Jin Yoo
Endocrinol Metab. 2019;34(4):406-414.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.406
  • 6,120 View
  • 85 Download
  • 16 Web of Science
  • 19 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Metabolically healthy obese (MHO) is regarded as a transient concept. We examined the effect of the dynamic change of metabolic health status on the incidence of type 2 diabetes mellitus (T2DM) both in obese and normal weight individuals.

Methods

We analyzed 3,479,514 metabolically healthy subjects aged over 20 years from the Korean National Health Screening Program, who underwent health examination between 2009 and 2010, with a follow-up after 4 years. The relative risk for T2DM incidence until the December 2017 was compared among the four groups: stable metabolically healthy normal weight (MHNW), unstable MHNW, stable MHO, and unstable MHO.

Results

During the 4 years, 11.1% of subjects in the MHNW group, and 31.5% in the MHO group converted to a metabolically unhealthy phenotype. In the multivariate adjusted model, the unstable MHO group showed the highest risk of T2DM (hazard ratio [HR], 4.67; 95% confidence interval [CI], 4.58 to 4.77). The unstable MHNW group had a higher risk of T2DM than stable MHO group ([HR, 3.23; 95% CI, 3.16 to 3.30] vs. [HR, 1.81; 95% CI, 1.76 to 1.85]). The stable MHO group showed a higher risk of T2DM than the stable MHNW group. The influence of the transition into a metabolically unhealthy phenotype on T2DM incidence was greater in subjects with aged <65 years, women, and those with weight gain.

Conclusion

Metabolically healthy phenotype was transient both in normal weight and obese individuals. Maintaining metabolic health was critical for the prevention of T2DM, irrespective of their baseline body mass index.

Citations

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    Hye Ah Lee, Hyesook Park
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    Aditya Verma, Ashok Jha, Ahmed Roshdy Alagorie, Rishi Sharma
    Eye.2023; 37(2): 303.     CrossRef
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    Dario Iafusco, Roberto Franceschi, Alice Maguolo, Salvatore Guercio Nuzio, Antonino Crinò, Maurizio Delvecchio, Lorenzo Iughetti, Claudio Maffeis, Valeria Calcaterra, Melania Manco
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    Ji Young Kim, Youngran Yang
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    Daye Diana Choi, Kyung-Ah Park, Kyungdo Han, Sei Yeul Oh
    Journal of Neuro-Ophthalmology.2023;[Epub]     CrossRef
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    Liying Li, Ziqiong Wang, Haiyan Ruan, Muxin Zhang, Linxia Zhou, Xin Wei, Ye Zhu, Jiafu Wei, Xiaoping Chen, Sen He
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    Qi Wu, Ming-Feng Xia, Xin Gao
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    Liping Yang, Xue Li, Li Wang, Shan Xu, Yanmei Lou, Fulan Hu
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    Chan Yang, Xiaowei Liu, Yuanyuan Dang, Juan Li, Jingyun Jing, Di Tian, Jiangwei Qiu, Jiaxing Zhang, Ni Yan, Xiuying Liu, Yi Zhao, Yuhong Zhang
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    Hidemi Hattori, Yuma Hanai, Yuto Oshima, Hiroaki Kataoka, Nozomu Eto
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Close layer
Clinical Study
Revisiting Rupture of Benign Thyroid Nodules after Radiofrequency Ablation: Various Types and Imaging Features
Sae Rom Chung, Jung Hwan Baek, Jin Yong Sung, Ji Hwa Ryu, So Lyung Jung
Endocrinol Metab. 2019;34(4):415-421.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.415
  • 5,977 View
  • 100 Download
  • 22 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

To evaluate the imaging features, clinical manifestations, and prognosis of patients with thyroid nodule rupture after radiofrequency ablation (RFA).

Methods

The records of 12 patients who experienced thyroid nodule rupture after RFA at four Korean thyroid centers between March 2010 and July 2017 were retrospectively reviewed. Clinical data evaluated included baseline patient characteristics, treatment methods, initial presenting symptoms, imaging features, treatment, and prognosis.

Results

The most common symptoms of post-RFA nodule rupture were sudden neck bulging and pain. Based on imaging features, the localization of nodule rupture was classified into three types: anterior, posterolateral, and medial types. The anterior type is the most often, followed by posterolateral and medial type. Eight patients recovered completely after conservative treatment. Four patients who did not improve with conservative management required invasive procedures, including incision and drainage or aspiration.

Conclusion

Thyroid nodule rupture after RFA can be classified into three types based on its localization: anterior, posterolateral, and medial types. Because majority of thyroid nodule ruptures after RFA can be managed conservatively, familiarity with these imaging features is essential in avoiding unnecessary imaging workup or invasive procedures.

Citations

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    Min Gang Jo, Min Kyoung Lee, Jae Ho Shin, Min Guk Seo, So Lyung Jung
    Journal of the Korean Society of Radiology.2024;[Epub]     CrossRef
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    Amanda J. Bastien, Luv Amin, Jeffrey Moses, Wendy Sacks, Allen S. Ho
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    Tatiana Ferraro, Sameeha Sajid, Steven P. Hodak, Chelsey K. Baldwin
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    Ningcheng Li, Timothy C. Huber
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    Heungrae Cho, Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee
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    Julia E Noel, Catherine F Sinclair
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Letter
Diabetes
Letter: Trends in Hyperglycemic Crisis Hospitalizations and in- and out-of-Hospital Mortality in the Last Decade Based on Korean National Health Insurance Claims Data (Endocrinol Metab 2019;34:275–81, Ji Hong You et al.)
Jang Won Son
Endocrinol Metab. 2019;34(4):422-423.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.422
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  • Incidence and predictors of hyperglycemic emergencies among adult diabetic patients in Bahir Dar city public hospitals, Northwest Ethiopia, 2021: A multicenter retrospective follow-up study
    Melsew Dagne Abate, Ayele Semachew, Solomon Emishaw, Fentahun Meseret, Molla Azmeraw, Dawit Algaw, Dessie Temesgen, Sefineh Fenta Feleke, Ahmed Nuru, Makda Abate, Berihun Bantie, Atsedemariam Andualem
    Frontiers in Public Health.2023;[Epub]     CrossRef
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