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Volume 37(5); October 2022
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Review Articles
Thyroid
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo
Endocrinol Metab. 2022;37(5):703-718.   Published online October 4, 2022
DOI: https://doi.org/10.3803/EnM.2022.1553
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  • 2,348 Download
  • 58 Web of Science
  • 72 Crossref
AbstractAbstract PDFPubReader   ePub   
The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categorized into three families (classes): benign tumors, low-risk neoplasms, and malignant neoplasms. The terms “follicular nodular disease” and “differentiated high-grade thyroid carcinoma” are introduced to account for multifocal hyperplastic/neoplastic lesions and differentiated thyroid carcinomas with high-grade features, respectively. The term “Hürthle cells” is replaced with “oncocytic cells.” Invasive encapsulated follicular and cribriform morular variants of papillary thyroid carcinoma (PTC) are now redefined as distinct tumor types, given their different genetic alterations and clinicopathologic characteristics from other PTC subtypes. The term “variant” to describe a subclass of tumor has been replaced with the term “subtype.” Instead, the term “variant” is reserved to describe genetic alterations. A histologic grading system based on the mitotic count, necrosis, and/or the Ki67 index is used to identify high-grade follicular-cell derived carcinomas and medullary thyroid carcinomas. The 2022 WHO classification introduces the following new categories: “salivary gland-type carcinomas of the thyroid” and “thyroid tumors of uncertain histogenesis.” This review summarizes the major changes in the 2022 WHO classification and their clinical relevance.

Citations

Citations to this article as recorded by  
  • Tumeurs de la thyroïde : nouveautés de la classification OMS 2022
    Serge Guyétant, Myriam Decaussin Petrucci, Emmanuelle Leteurtre
    Annales de Pathologie.2024; 44(1): 5.     CrossRef
  • Diagnostic Performance of [18F]TFB PET/CT Compared with Therapeutic Activity [131I]Iodine SPECT/CT and [18F]FDG PET/CT in Recurrent Differentiated Thyroid Carcinoma
    David Ventura, Matthias Dittmann, Florian Büther, Michael Schäfers, Kambiz Rahbar, Daniel Hescheler, Michael Claesener, Philipp Schindler, Burkhard Riemann, Robert Seifert, Wolfgang Roll
    Journal of Nuclear Medicine.2024; 65(2): 192.     CrossRef
  • Clinicopathological features of differentiated thyroid carcinoma as predictors of the effects of radioactive iodine therapy
    Wen Liu, Beibei Jiang, Jingli Xue, Ruijing Liu, Yuqing Wei, Peifeng Li
    Annals of Diagnostic Pathology.2024; 69: 152243.     CrossRef
  • Management of aggressive variants of papillary thyroid cancer
    Ying Ki Lee, Aleix Rovira, Paul V. Carroll, Ricard Simo
    Current Opinion in Otolaryngology & Head & Neck Surgery.2024; 32(2): 125.     CrossRef
  • Artificial Intelligence Detected the Relationship Between Nuclear Morphological Features and Molecular Abnormalities of Papillary Thyroid Carcinoma
    Toui Nishikawa, Ibu Matsuzaki, Ayata Takahashi, Iwamoto Ryuta, Fidele Yambayamba Musangile, Kanako Sagan, Mizuki Nishikawa, Yurina Mikasa, Yuichi Takahashi, Fumiyoshi Kojima, Shin-ichi Murata
    Endocrine Pathology.2024; 35(1): 40.     CrossRef
  • Review of the 2023 World Congress on Thyroid Cancer (WCTC 2023, London): is there light at the end of the tunnel for patients with neglected cancer?
    S.M. Cherenko
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2024; 19(8): 609.     CrossRef
  • Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma
    Lindsay A. Bischoff, Ian Ganly, Laura Fugazzola, Erin Buczek, William C. Faquin, Bryan R. Haugen, Bryan McIver, Caitlin P. McMullen, Kate Newbold, Daniel J. Rocke, Marika D. Russell, Mabel Ryder, Peter M. Sadow, Eric Sherman, Maisie Shindo, David C. Shonk
    JAMA Otolaryngology–Head & Neck Surgery.2024; 150(3): 265.     CrossRef
  • Malignancy in a Solitary Thyroid Nodule: A Retrospective Histopathological Evaluation
    Hassan Alzahrani
    International Journal of General Medicine.2024; Volume 17: 135.     CrossRef
  • Pathologie thyroïdienne. Actualités et problèmes pratiques. Introduction
    Serge Guyétant
    Annales de Pathologie.2024; 44(2): 90.     CrossRef
  • Diagnostic implication of thyroid spherules for cytological diagnosis of thyroid nodules
    Heeseung Sohn, Kennichi Kakudo, Chan Kwon Jung
    Cytopathology.2024; 35(3): 383.     CrossRef
  • Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement
    Marius Mitrache, Dana Terzea, Anca Sirbu, Simona Fica
    Biomedicines.2024; 12(2): 285.     CrossRef
  • Unravelling the role of long non-coding RNAs in modulating the Hedgehog pathway in cancer
    Shailendra Singh Chandel, Anurag Mishra, Gaurav Dubey, Ravindra Pal Singh, Mithilesh Singh, Mohit Agarwal, Himmat Singh Chawra, Neelima Kukreti
    Pathology - Research and Practice.2024; 254: 155156.     CrossRef
  • Hürthle cell (Oncocytic) carcinoma – Is hemithyroidectomy enough?
    Taylor O. Julsrud, Trenton R. Foster, Robert A. Vierkant, Melanie L. Lyden, Travis J. McKenzie, Mabel Ryder, Benzon M. Dy
    Surgical Oncology Insight.2024; 1(1): 100010.     CrossRef
  • Échographie des carcinomes thyroïdiens différenciés de souche folliculaire
    P.Y. Marcy, M. Tassart, J.G. Marchand, J. Sanglier, A. Bizeau, E. Ghanassia
    Journal d'imagerie diagnostique et interventionnelle.2024; 7(2): 54.     CrossRef
  • Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study
    Chankyung Kim, Shipra Agarwal, Andrey Bychkov, Jen-Fan Hang, Agnes Stephanie Harahap, Mitsuyoshi Hirokawa, Kennichi Kakudo, Somboon Keelawat, Chih-Yi Liu, Zhiyan Liu, Truong Phan-Xuan Nguyen, Chanchal Rana, Huy Gia Vuong, Yun Zhu, Chan Kwon Jung
    Virchows Archiv.2024; 484(4): 645.     CrossRef
  • Cas no5. High-grade Tall cell papillary carcinoma
    Myriam Decaussin-Petrucci
    Annales de Pathologie.2024; 44(2): 114.     CrossRef
  • Primary Squamous Cell Carcinoma of the Thyroid Has a Molecular Genetic Profile Distinct From That of Anaplastic Thyroid Carcinoma
    Meihua Ye, Zhenying Guo, Jingjing Xu, Yanling Jin, Xianglei He, Minghua Ge
    American Journal of Surgical Pathology.2024;[Epub]     CrossRef
  • Current and future of immunotherapy for thyroid cancer based on bibliometrics and clinical trials
    Ke Wang, Ying Zhang, Yang Xing, Hong Wang, Minghua He, Rui Guo
    Discover Oncology.2024;[Epub]     CrossRef
  • Cas no6. Anaplastic thyroid carcinoma, epidermoid subtype
    Myriam Decaussin-Petrucci
    Annales de Pathologie.2024; 44(2): 120.     CrossRef
  • Papillary Thyroid Carcinoma With Lymphoepithelial Features and Lacking Association With Epstein-Barr Virus (EBV): A Rare Case
    Ahmed Bendari, Saroja Devi Geetha, Reham Al-Refai, Xuelin Zhong, Sunder Sham, Manju Harshan
    Cureus.2024;[Epub]     CrossRef
  • Clinical and morphological features and unsolved issues in diagnosis of aggressive forms of papillary thyroid carcinoma
    Denis V. Korotovsky, Sergey V. Sergiiko, Sergey A. Lukyanov
    Perm Medical Journal.2024; 41(1): 90.     CrossRef
  • Finding possible diagnostic markers for differentiating benign and malignant thyroid tumors on example investigate of rheological properties1
    I. Javakhishvili, T. Sanikidze, K. Mardaleishvili, N. Momtselidze, T. Urdulashvili, M. Mantskava, L. Prantl, F. Jung
    Clinical Hemorheology and Microcirculation.2024; : 1.     CrossRef
  • Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma
    Lia Rodrigues, Arnaud Da Cruz Paula, Paula Soares, João Vinagre
    Cells.2024; 13(7): 561.     CrossRef
  • Management of Poorly Differentiated Thyroid Cancer and Differentiated High-Grade Thyroid Carcinoma
    Iram S. Alam, Kepal N. Patel
    Surgical Clinics of North America.2024;[Epub]     CrossRef
  • What’s new in thyroid pathology 2024: updates from the new WHO classification and bethesda system
    Andrey Bychkov, Chan Kwon Jung
    Journal of Pathology and Translational Medicine.2024; 58(2): 98.     CrossRef
  • Ultrasound–Histopathological Presentation of Thyroid and Ovary Lesions in Adolescent Patients with DICER1 Syndrome: Case Reports and Literature Overview
    Dominika Januś, Monika Kujdowicz, Konrad Kaleta, Kamil Możdżeń, Jan Radliński, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Marcin Maślanka, Wojciech Górecki, Jerzy B. Starzyk
    Children.2024; 11(4): 403.     CrossRef
  • Surgical treatment of solid variant of papillary thyroid carcinoma: Fifteen-year experience of a tertiary center
    Katarina Tausanović, Marina Stojanović, Milan Jovanović, Boban Stepanović, Jovan Ilić, Sara Ivaniš, Vladan Živaljević
    Medicinska istrazivanja.2024; 57(1): 121.     CrossRef
  • Critical appraisal of the WHO 2022 classification of thyroid cancer
    Mithraa Devi Sekar, Debasis Gochhait, Sadishkumar Kamalanathan
    Thyroid Research and Practice.2024; 20(1): 8.     CrossRef
  • Patterns in the Reporting of Aggressive Histologic Subtypes in Papillary Thyroid Cancer
    Yeon J. Lee, Caitlin E. Egan, Jacques A. Greenberg, Teagan Marshall, Abhinay Tumati, Brendan M. Finnerty, Toni Beninato, Rasa Zarnegar, Thomas J. Fahey, Minerva A. Romero Arenas
    Journal of Surgical Research.2024; 298: 325.     CrossRef
  • An individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma
    Zhihong Wang, He Wang, Yan Zhou, Lu Li, Mengge Lyu, Chunlong Wu, Tianen He, Lingling Tan, Yi Zhu, Tiannan Guo, Hongkun Wu, Hao Zhang, Yaoting Sun
    Nature Communications.2024;[Epub]     CrossRef
  • Clinical and Paraclinical Considerations Regarding ki67’s Role in the Management of Differentiated Thyroid Carcinoma—A Literature Review
    Claudiu Peștean, Alexandru Pavel, Doina Piciu
    Medicina.2024; 60(5): 769.     CrossRef
  • Can the analysis of chromatin texture and nuclear fractal dimensions serve as effective means to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features from other malignancies with follicular pattern in the thyroid?: a s
    Geet Bhuyan, Anjumoni Rabha
    Ultrastructural Pathology.2024; : 1.     CrossRef
  • A Comprehensive Review and Insights into the New Entity of Differentiated High-Grade Thyroid Carcinoma
    Agnes Stephanie Harahap, Regina Stefani Roren, Shofiyya Imtiyaz
    Current Oncology.2024; 31(6): 3311.     CrossRef
  • Predictive Factors of Radioactive Iodine Therapy Refractoriness in Patients with Differentiated Thyroid Carcinoma
    Majdouline Bel Lakhdar, Ayat Mouaden, Mourad Zekri, Dounia Alami, Hamza Zarouf, Imad Ghfir, Hasnae Guerrouj
    World Journal of Nuclear Medicine.2024;[Epub]     CrossRef
  • Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 4. Pathological Diagnosis and Staging after Thyroidectomy 2024
    Su-Jin Shin, Hee Young Na, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Young Joo Park, Young Shin Song, Eun Kyung Lee, Dong-Jun Lim, Yun Jae Chung, Chan Kwon Jung
    International Journal of Thyroidology.2024; 17(1): 61.     CrossRef
  • Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma
    Chan Kwon Jung, Shipra Agarwal, Jen-Fan Hang, Dong-Jun Lim, Andrey Bychkov, Ozgur Mete
    Endocrine Pathology.2023; 34(1): 1.     CrossRef
  • The 5th edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma
    Fulvio Basolo, Elisabetta Macerola, Anello Marcello Poma, Liborio Torregrossa
    Endocrine.2023; 80(3): 470.     CrossRef
  • Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subtyping and RAS Variant-specific Immunohistochemistry
    Meejeong Kim, Sora Jeon, Chan Kwon Jung
    Endocrine Pathology.2023; 34(2): 247.     CrossRef
  • Ultrasound evolution of parenchymal changes in the thyroid gland with autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma – a follow-up study
    Dominika Januś, Monika Kujdowicz, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Wojciech Górecki, Jerzy B. Starzyk
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Papillary thyroid carcinoma with aggressive fused follicular and solid growth pattern: A unique histological subtype with high‐grade malignancy?
    Shin‐ichi Murata, Ibu Matsuzaki, Mitsuo Kishimoto, Naomi Katsuki, Toshinori Onishi, Mitsuyoshi Hirokawa, Fumiyoshi Kojima
    Pathology International.2023; 73(5): 207.     CrossRef
  • Multi-Omics and Management of Follicular Carcinoma of the Thyroid
    Thifhelimbilu Emmanuel Luvhengo, Ifongo Bombil, Arian Mokhtari, Maeyane Stephens Moeng, Demetra Demetriou, Claire Sanders, Zodwa Dlamini
    Biomedicines.2023; 11(4): 1217.     CrossRef
  • Molecular Genetics of Diffuse Sclerosing Papillary Thyroid Cancer
    Meshael Alswailem, Balgees Alghamdi, Anwar Alotaibi, Abeer Aljomiah, Hindi Al-Hindi, Avaniyapuram Kannan Murugan, Mohamed Abouelhoda, Yufei Shi, Ali S Alzahrani
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(9): e704.     CrossRef
  • Multifunctional Phase-Transition Nanoparticles for Effective Targeted Sonodynamic-Gene Therapy Against Thyroid Papillary Carcinoma
    Shihui Guan, Dengke Teng, Hui Wang, Qimeihui Wang, Xi Zhen, Guoqing Sui, Yang Wang, Lingyu Zhu, Yuanqiang Lin, Dan Jiao, Feng Guo
    International Journal of Nanomedicine.2023; Volume 18: 2275.     CrossRef
  • Utilizing Dynamic Risk Stratification in Patients With Tall Cell Variant Papillary Thyroid Cancer
    David Zimmer, Gilman Plitt, Brandon Prendes, Jamie Ku, Natalie Silver, Eric Lamarre, Emrullah Yilmaz, Jessica Geiger, Christian Nasr, Lea El Hage, Mario Skugor, Shauna Cambpell, Shlomo Koyfman, Jacob Miller, Neil Woody, Katherine Heiden, Nikhil Joshi, Tar
    The Laryngoscope.2023; 133(9): 2430.     CrossRef
  • Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022
    Dominika Januś, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Monika Kujdowicz, Małgorzata Czogała, Wojciech Górecki, Jerzy B. Starzyk
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Medullary Thyroid Carcinoma: A Single Institute Experience
    Sonal Trivedi, T. Salahuddin, Mohamed Taher Mithi, Priyank Rathod, Arpit Bandi, Shashank J. Pandya, Mohit Sharma, Shailesh Patel, Vikas Warikoo, Ketul Puj, Abhijeet Salunkhe, Keval Patel, Shivam Pandya
    Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 2884.     CrossRef
  • FNAC (Fine needle aspiration cytology) and histopathological correlation and reclassification of thyroid neoplasm in accordance with WHO classification 2022
    Fareeda Joshi, Shreya Hegde
    Indian Journal of Pathology and Oncology.2023; 10(2): 132.     CrossRef
  • Papillary thyroid carcinoma associated with non‑functioning parathyroid carcinoma with Warthin's tumor of the parotid gland: A case report and brief literature review
    Ari Abdullah, Aras Qaradakhy, Yadgar Saeed, Abdulwahid Salih, Seema Karim, Osama Ali, Shko Hassan, Shalaw Nasraldeen, Shvan Mohammed, Fahmi Kakamad
    Medicine International.2023;[Epub]     CrossRef
  • Warthin-like papillary thyroid carcinoma: a case report and comprehensive review of the literature
    Abdel Mouhaymen Missaoui, Fatma Hamza, Wafa Belabed, Manel Mellouli, Mohamed Maaloul, Slim Charfi, Issam Jardak, Tahya Sellami-Boudawara, Nabila Rekik, Mohamed Abid
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Reevaluating diagnostic categories and associated malignancy risks in thyroid core needle biopsy
    Chan Kwon Jung
    Journal of Pathology and Translational Medicine.2023; 57(4): 208.     CrossRef
  • Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
    Ioana Balinisteanu, Monica-Cristina Panzaru, Lavinia Caba, Maria-Christina Ungureanu, Andreea Florea, Ana Maria Grigore, Eusebiu Vlad Gorduza
    Biomedicines.2023; 11(8): 2143.     CrossRef
  • Deep learning prediction model for central lymph node metastasis in papillary thyroid microcarcinoma based on cytology
    Wenhao Ren, Yanli Zhu, Qian Wang, Yuntao Song, Zhihui Fan, Yanhua Bai, Dongmei Lin
    Cancer Science.2023; 114(10): 4114.     CrossRef
  • Cytology and Histology of Thyroid Nodules: Exploring Novel Insights in the Molecular Era for Enhanced Patient Management
    Beatrix Cochand-Priollet, Zahra Maleki
    Current Oncology.2023; 30(8): 7753.     CrossRef
  • Agrin is a novel oncogenic protein in thyroid cancer
    Anna Adamiok‑Ostrowska, Małgorzata Grzanka, Barbara Czarnocka
    Oncology Letters.2023;[Epub]     CrossRef
  • Analysis of Pathological Features of Thyroid Carcinoma in the Western Yunnan
    身吾 王
    Advances in Clinical Medicine.2023; 13(10): 15820.     CrossRef
  • Insight of novel biomarkers for papillary thyroid carcinoma through multiomics
    Wei Liu, Junkan Zhu, Zhen Wu, Yongxiang Yin, Qiao Wu, Yiming Wu, Jiaojiao Zheng, Cong Wang, Hongyan Chen, Talal Jamil Qazi, Jun Wu, Yuqing Zhang, Houbao Liu, Jingmin Yang, Daru Lu, Xumin Zhang, Zhilong Ai
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Identification of NIFTP-Specific mRNA Markers for Reliable Molecular Diagnosis of Thyroid Tumors
    So-Yeon Lee, Jong-Lyul Park, Kwangsoon Kim, Ja Seong Bae, Jae-Yoon Kim, Seon-Young Kim, Chan Kwon Jung
    Endocrine Pathology.2023; 34(3): 311.     CrossRef
  • Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment
    Andrea Gillis, Rui Zheng-Pywell, Chandler McLeod, Dezhi Wang, John M. Ness, Rachael Guenter, Jason Whitt, Tomas A. Prolla, Herbert Chen, Manuel Lora Gonzalez, Bart Rose, Ricardo V. Lloyd, Renata Jaskula-Sztul, Diana Lin
    Modern Pathology.2023; 36(12): 100332.     CrossRef
  • Comparison of Treatment and Prognosis Between Follicular Variant Papillary Thyroid Carcinoma and Classical Papillary Thyroid Carcinoma
    Bing Zhang, Wenming Wu, Jinjing Liu, Zhou Liang, Liang Zong
    Hormone and Metabolic Research.2023; 55(12): 855.     CrossRef
  • Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
    Isabella Merante Boschin, Loris Bertazza, Carla Scaroni, Caterina Mian, Maria Rosa Pelizzo
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Utility of the Growth Differentiation Factor-15 in the Differential Diagnosis of Follicular-Patterned Lesions of the Thyroid on Cytopathologic and Histopathologic Samples
    Prasanna V Perumal, Neelaiah Siddaraju, Sunil K Saxena, Soundravally Rajendiran, Ramachandra V Bhat
    Cureus.2023;[Epub]     CrossRef
  • Investigation of pre‐operative demographic, biochemical, sonographic and cytopathological findings in low‐risk thyroid neoplasms
    Muzaffer Serdar Deniz, Didem Özdemir, Narin Nasıroğlu İmga, Hüsniye Başer, Fatma Neslihan Çuhacı Seyrek, Ayşegül Aksoy Altınboğa, Oya Topaloğlu, Reyhan Ersoy, Bekir Çakır
    Clinical Endocrinology.2023; 99(5): 502.     CrossRef
  • Applications of machine and deep learning to thyroid cytology and histopathology: a review
    Greg Slabaugh, Luis Beltran, Hasan Rizvi, Panos Deloukas, Eirini Marouli
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • The Asian Thyroid Working Group, from 2017 to 2023
    Kennichi Kakudo, Chan Kwon Jung, Zhiyan Liu, Mitsuyoshi Hirokawa, Andrey Bychkov, Huy Gia Vuong, Somboon Keelawat, Radhika Srinivasan, Jen-Fan Hang, Chiung-Ru Lai
    Journal of Pathology and Translational Medicine.2023; 57(6): 289.     CrossRef
  • Anaplastic thyroid cancer: Pathogenesis, prognostic factors and genetic landscape (Review)
    Abdul-Mohsen Alhejaily, Omar Alhuzim, Yazeed Alwelaie
    Molecular and Clinical Oncology.2023;[Epub]     CrossRef
  • Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review
    Poupak Fallahi, Armando Patrizio, Giulio Stoppini, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Eugenia Balestri, Valeria Mazzi, Chiara Botrini, Gilda Varricchi, Salvatore Ulisse, Marco Ghionzoli, Alessandro Antonelli, Silvia Martina Ferrari
    Current Oncology.2023; 30(12): 10237.     CrossRef
  • Construction and validation of a nomogram for predicting cervical lymph node metastasis in diffuse sclerosing variant of papillary thyroid carcinoma
    Xunyi Lin, Jiaxing Huo, Huan Zhang, Hang Su, Fenghua Zhang
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization
    Jana Jankovic, Eve Tièche, Martina Dettwiler, Kerstin Hahn, Stephanie Scheemaeker, Martin Kessler, Sylvie Daminet, Sven Rottenberg, Miguel Campos
    Veterinary Pathology.2023;[Epub]     CrossRef
  • A 16-Year Single-Center Series of Trachea Resections for Locally Advanced Thyroid Carcinoma
    Julia I. Staubitz-Vernazza, Sina Schwind, Oana Lozan, Thomas J. Musholt
    Cancers.2023; 16(1): 163.     CrossRef
  • Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer
    Yuji Nagayama, Koichiro Hamada
    Metabolites.2022; 12(12): 1214.     CrossRef
  • Developments to improve outcomes in thyroid surgery
    Thomas J. Musholt
    Innovative Surgical Sciences.2022; 7(3-4): 77.     CrossRef
  • The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure
    Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I. Rogounovitch, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Sergii Masiuk, Shunichi Yamashita, Vladimir A. Saenko
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
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Hypothalamus and Pituitary Gland
Independent Skeletal Actions of Pituitary Hormones
Se-Min Kim, Farhath Sultana, Funda Korkmaz, Daria Lizneva, Tony Yuen, Mone Zaidi
Endocrinol Metab. 2022;37(5):719-731.   Published online September 28, 2022
DOI: https://doi.org/10.3803/EnM.2022.1573
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AbstractAbstract PDFPubReader   ePub   
Over the past years, pituitary hormones and their receptors have been shown to have non-traditional actions that allow them to bypass the hypothalamus-pituitary-effector glands axis. Bone cells—osteoblasts and osteoclasts—express receptors for growth hormone, follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), prolactin, oxytocin, and vasopressin. Independent skeletal actions of pituitary hormones on bone have been studied using genetically modified mice with haploinsufficiency and by activating or inactivating the receptors pharmacologically, without altering systemic effector hormone levels. On another front, the discovery of a TSH variant (TSH-βv) in immune cells in the bone marrow and skeletal action of FSHβ through tumor necrosis factor α provides new insights underscoring the integrated physiology of bone-immune-endocrine axis. Here we discuss the interaction of each pituitary hormone with bone and the potential it holds in understanding bone physiology and as a therapeutic target.

Citations

Citations to this article as recorded by  
  • New tools for bone health assessment in secreting pituitary adenomas
    Meliha Melin Uygur, Stefano Frara, Luigi di Filippo, Andrea Giustina
    Trends in Endocrinology & Metabolism.2023; 34(4): 231.     CrossRef
  • A Causality between Thyroid Function and Bone Mineral Density in Childhood: Abnormal Thyrotropin May Be Another Pediatric Predictor of Bone Fragility
    Dongjin Lee, Moon Ahn
    Metabolites.2023; 13(3): 372.     CrossRef
  • The mechanism of oxytocin and its receptors in regulating cells in bone metabolism
    Liu Feixiang, Feng Yanchen, Li Xiang, Zhang Yunke, Miao Jinxin, Wang Jianru, Lin Zixuan
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • To investigate the mechanism of Yiwei Decoction in the treatment of premature ovarian insufficiency-related osteoporosis using transcriptomics, network pharmacology and molecular docking techniques
    Weisen Fan, Yan Meng, Jing Zhang, Muzhen Li, Yingjie Zhang, Xintian Qu, Xin Xiu
    Scientific Reports.2023;[Epub]     CrossRef
Close layer
Calcium & Bone Metabolism
Updates on Paget’s Disease of Bone
Yong Jun Choi, Young Bae Sohn, Yoon-Sok Chung
Endocrinol Metab. 2022;37(5):732-743.   Published online October 25, 2022
DOI: https://doi.org/10.3803/EnM.2022.1575
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AbstractAbstract PDFPubReader   ePub   
Paget’s disease of the bone is a prevalent bone disease characterized by disorganized bone remodeling; however, it is comparatively uncommon in East Asian countries, including China, Japan, and Korea. The exact cause still remains unknown. In genetically susceptible individuals, environmental triggers such as paramyxoviral infections are likely to cause the disease. Increased osteoclast activity results in increased bone resorption, which attracts osteoblasts and generates new bone matrix. Fast bone resorption and formation lead to the development of disorganized bone tissue. Increasing serum alkaline phosphatase or unique radiographic lesions may serve as the diagnostic indicators. Common symptoms include bone pain, bowing of the long bones, an enlarged skull, and hearing loss. The diagnosis is frequently confirmed by radiographic and nuclear scintigraphy of the bone. Further, bisphosphonates such as zoledronic acid and pamidronate are effective for its treatment. Moreover, biochemical monitoring is superior to the symptoms as a recurrence indicator. This article discusses the updates of Paget’s disease of bone with a clinical case.

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  • Effects of Erythropoietin-Promoted Fracture Healing on Bone Turnover Markers in Cats
    Radina Vasileva, Tsvetan Chaprazov, Aneliya Milanova
    Journal of Functional Biomaterials.2024; 15(4): 106.     CrossRef
  • Osteogenesis imperfecta type 10 and the cellular scaffolds underlying common immunological diseases
    Alan Herbert
    Genes & Immunity.2024;[Epub]     CrossRef
  • Newly Diagnosed Monostotic Paget’s Disease of Bone during Living Kidney Donor Candidate Evaluation
    Diana Jędrzejuk, Paweł Poznański, Paweł Szewczyk, Oktawia Mazanowska, Marek Bolanowski, Magdalena Krajewska, Dorota Kamińska
    Biomedicines.2023; 11(2): 401.     CrossRef
  • Paget's disease of bone in the patient presented with a bowed leg
    Mehrzad Hajialiloo, Sepideh Tahsini Tekantapeh
    Clinical Case Reports.2023;[Epub]     CrossRef
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Calcium & Bone Metabolism
Update on Preoperative Parathyroid Localization in Primary Hyperparathyroidism
Hye-Sun Park, Namki Hong, Jong Ju Jeong, Mijin Yun, Yumie Rhee
Endocrinol Metab. 2022;37(5):744-755.   Published online October 25, 2022
DOI: https://doi.org/10.3803/EnM.2022.1589
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AbstractAbstract PDFPubReader   ePub   
Parathyroidectomy is the treatment of choice for primary hyperparathyroidism when the clinical criteria are met. Although bilateral neck exploration is traditionally the standard method for surgery, minimally invasive parathyroidectomy (MIP), or focused parathyroidectomy, has been widely accepted with comparable curative outcomes. For successful MIP, accurate preoperative localization of parathyroid lesions is essential. However, no consensus exists on the optimal approach for localization. Currently, ultrasonography and technetium-99m-sestamibi–single photon emission computed tomography/computed tomography are widely accepted in most cases. However, exact localization cannot always be achieved, especially in cases with multiglandular disease, ectopic glands, recurrent disease, and normocalcemic primary hyperparathyroidism. Therefore, new modalities for preoperative localization have been developed and evaluated. Positron emission tomography/computed tomography and parathyroid venous sampling have demonstrated improvements in sensitivity and accuracy. Both anatomical and functional information can be obtained by combining these methods. As each approach has its advantages and disadvantages, the localization study should be deliberately chosen based on each patient’s clinical profile, costs, radiation exposure, and the availability of experienced experts. In this review, we summarize various methods for the localization of hyperfunctioning parathyroid tissues in primary hyperparathyroidism.

Citations

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  • Expression of the Calcium-Sensing Receptor on Normal and Abnormal Parathyroid and Thyroid Tissue
    Anne L. Worth, Mesrop Ayrapetyan, Susan J. Maygarden, Zibo Li, Zhanhong Wu, Chris B. Agala, Lawrence T. Kim
    Journal of Surgical Research.2024; 293: 618.     CrossRef
  • Use of [18F]fluorocholine PET/CT in the detection of primary hyperparathyroidism in paediatrics: a case report
    Helena Martínez Sánchez, Francisca Moreno Macián, Sara León Cariñena, Carmen de Mingo Alemany, Lidia Blasco González, Raquel Sánchez Vañó
    Journal of Pediatric Endocrinology and Metabolism.2024; 37(6): 580.     CrossRef
  • A Rare Case of Hyperfunctioning Lipoadenoma Presenting as a Cystic Pararthyroid Lesion
    Jinyoung Kim, Ohjoon Kwon, Tae-Jung Kim, So Lyung Jung, Eun Ji Han, Ki-Ho Song
    Journal of Bone Metabolism.2023; 30(2): 201.     CrossRef
  • Role of 18F-Fluorocholine Positron Emission Tomography (PET)/Computed Tomography (CT) in Diagnosis of Elusive Parathyroid Adenoma
    Janan R Badier, Pokhraj P Suthar, Jagadeesh S Singh, Miral D Jhaveri
    Cureus.2023;[Epub]     CrossRef
  • Pitfalls of DualTracer 99m-Technetium (Tc) Pertechnetate and Sestamibi Scintigraphy before Parathyroidectomy: Between Primary-Hyperparathyroidism-Associated Parathyroid Tumour and Ectopic Thyroid Tissue
    Mara Carsote, Mihaela Stanciu, Florina Ligia Popa, Oana-Claudia Sima, Eugenia Petrova, Anca-Pati Cucu, Claudiu Nistor
    Medicina.2023; 60(1): 15.     CrossRef
  • Diagnostic Performance of Magnetic Resonance Imaging for Parathyroid Localization of Primary Hyperparathyroidism: A Systematic Review
    Max H. M. C. Scheepers, Zaid Al-Difaie, Lloyd Brandts, Andrea Peeters, Bjorn Winkens, Mahdi Al-Taher, Sanne M. E. Engelen, Tim Lubbers, Bas Havekes, Nicole D. Bouvy, Alida A. Postma
    Diagnostics.2023; 14(1): 25.     CrossRef
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Editorial
Diabetes, Obesity and Metabolism
You Can’t Avoid Shift Work? Then Focus on Body Fat Rather than Weight
Eun Kyung Lee
Endocrinol Metab. 2022;37(5):756-758.   Published online October 25, 2022
DOI: https://doi.org/10.3803/EnM.2022.501
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  • 133 Download
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Original Articles
Diabetes, Obesity and Metabolism
Big Data Articles (National Health Insurance Service Database)
Association between the Diabetes Drug Cost and Cardiovascular Events and Death in Korea: A National Health Insurance Service Database Analysis
Seung Min Chung, Ji-In Lee, Eugene Han, Hyun-Ae Seo, Eonju Jeon, Hye Soon Kim, Ji Sung Yoon
Endocrinol Metab. 2022;37(5):759-769.   Published online October 5, 2022
DOI: https://doi.org/10.3803/EnM.2022.1515
  • 3,534 View
  • 199 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study aimed to investigate the long-term effects of diabetes drug costs on cardiovascular (CV) events and death.
Methods
This retrospective observational study used data from 2009 to 2018 from the National Health Insurance in Korea. Among the patients with type 2 diabetes, those taking antidiabetic drugs and who did not have CV events until 2009 were included. Patients were divided into quartiles (Q1 [lowest]–4 [highest]) according to the 2009 diabetes drug cost. In addition, the 10-year incidences of CV events (non-fatal myocardial infarction, stroke, hospitalization for heart failure, and coronary revascularization) and CV death (death due to CV events) were analyzed.
Results
A total of 441,914 participants were enrolled (median age, 60 years; men, 57%). CV events and death occurred in 28.1% and 8.36% of the patients, respectively. The 10-year incidences of CV events and deaths increased from Q1 to 4. After adjusting for sex, age, income, type of diabetes drugs, comorbidities, and smoking and drinking status, the risk of CV events significantly increased according to the sequential order of the cost quartiles. In contrast, the risk of CV death showed a U-shaped pattern, which was the lowest in Q3 (hazard ratio [HR], 0.953; 95% confidence interval [CI], 0.913 to 0.995) and the highest in Q4 (HR, 1.266; 95% CI, 1.213 to 1.321).
Conclusion
Diabetes drug expenditure affects 10-year CV events and mortality. Therefore, affording an appropriate diabetes drug cost at a similar risk of CV is an independent protective factor against CV death.

Citations

Citations to this article as recorded by  
  • Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: a cohort study
    Tae Kyung Yoo, Kyung-Do Han, Eun-Jung Rhee, Won-Young Lee
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
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Diabetes, Obesity and Metabolism
Big Data Articles (National Health Insurance Service Database)
Association among Current Smoking, Alcohol Consumption, Regular Exercise, and Lower Extremity Amputation in Patients with Diabetic Foot: Nationwide Population-Based Study
Yoon Jae Lee, Kyung-Do Han, Jun Hyeok Kim
Endocrinol Metab. 2022;37(5):770-780.   Published online October 12, 2022
DOI: https://doi.org/10.3803/EnM.2022.1519
  • 3,666 View
  • 213 Download
  • 3 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
The present study investigates whether modifiable behavioral factors of current cigarette smoking, heavy alcohol consumption, and regular exercise are associated with risk of lower extremity amputation (LEA) in diabetic patients.
Methods
A total of 2,644,440 diabetic patients (aged ≥20 years) was analyzed using the database of the Korean National Health Insurance Service. Cox proportional hazard regression was used to assess adjusted hazard ratios (HRs) for the behavioral factors with risk of LEA under adjustment for potential confounders.
Results
The risk of LEA was significantly increased by current cigarette smoking and heavy alcohol consumption (HR, 1.436; 95% confidence interval [CI], 1.367 to 1.508 and HR, 1.082; 95% CI, 1.011 to 1.158) but significantly decreased with regular exercise (HR, 0.745; 95% CI, 0.706 to 0.786) after adjusting for age, sex, smoking, alcohol consumption, exercise, low income, hypertension, dyslipidemia, body mass index, using insulin or oral antidiabetic drugs, and diabetic duration. A synergistically increased risk of LEA was observed with larger number of risky behaviors.
Conclusion
Modification of behaviors of current smoking, heavy alcohol intake, and exercise prevents LEA and can improve physical, emotional, and social quality of life in diabetic patients.

Citations

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  • Adjuvant effect of antimicrobial photodynamic therapy (aPDT) in the treatment of diabetic foot ulcers: A case series
    Rita de Cassia Ferreira, Rebeca Boltes Cecatto, Silvana Torres Perez, Raquel Agnelli Mesquita‐Ferrari, Sandra Kalil Bussadori, Cinthya Cosme Duran, Anna Carolina Tempestini Horliana, Kristianne Porta Santos Fernandes
    Journal of Biophotonics.2024;[Epub]     CrossRef
  • Factors associated with diabetic foot ulcers and lower limb amputations in type 1 and type 2 diabetes supported by real‐world data from the German/Austrian DPV registry
    Alexander J. Eckert, Stefan Zimny, Marcus Altmeier, Ana Dugic, Anton Gillessen, Latife Bozkurt, Gabriele Götz, Wolfram Karges, Frank J. Wosch, Stephan Kress, Reinhard W. Holl
    Journal of Diabetes.2024;[Epub]     CrossRef
  • A randomized controlled trial of an app-based intervention on physical activity and glycemic control in people with type 2 diabetes
    Gyuri Kim, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    BMC Medicine.2024;[Epub]     CrossRef
  • Influence of quitting smoking on diabetes-related complications: A scoping review with a systematic search strategy
    Magdalena Walicka, Arkadiusz Krysiński, Giusy Rita Maria La Rosa, Ang Sun, Davide Campagna, Agostino Di Ciaula, Tabinda Dugal, Andre Kengne, Phuong Le Dinh, Anoop Misra, Riccardo Polosa, Syed Abbas Raza, Cristina Russo, Roberta Sammut, Noel Somasundaram
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(5): 103044.     CrossRef
  • Investigating Diabetic Foot Pathophysiology and Amputation Prevention Strategies through Behavioral Modification
    Jun Hyeok Kim
    Journal of Wound Management and Research.2023; 19(3): 167.     CrossRef
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Diabetes, Obesity and Metabolism
Association of Shift Work with Normal-Weight Obesity in Community-Dwelling Adults
Chul Woo Ahn, Sungjae Shin, Seunghyun Lee, Hye-Sun Park, Namki Hong, Yumie Rhee
Endocrinol Metab. 2022;37(5):781-790.   Published online October 25, 2022
DOI: https://doi.org/10.3803/EnM.2022.1532
  • 3,723 View
  • 195 Download
  • 3 Web of Science
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Shift work is associated with obesity and metabolic syndrome. However, this association in the normal-weight population remains unclear. This study aimed to investigate whether shift work is associated with normal-weight obesity (NWO).
Methods
From the nationally representative Korea National Health and Nutrition Examination Survey (KNHANES) dataset (2008 to 2011), 3,800 full-time workers aged ≥19 years with a body mass index (BMI) ≤25 kg/m2 were analysed. We defined NWO as BMI ≤25 kg/m2 and body fat percentage ≥25% in men and ≥37% in women. Working patterns were classified into “daytime,” “other than daytime,” and “shift.” Multivariable logistic regression analysis was performed to evaluate the relationship between shift work and NWO.
Results
Shift work was associated with higher odds of NWO than daytime work (adjusted odds ratio [aOR], 1.47; 95% confidence interval [CI], 1.04 to 2.09) and night/evening work (aOR, 1.87; 95% CI, 1.11 to 3.14) after adjustment for type of work, working hours, age, sex, BMI, 25-hydroxyvitamin D levels, homeostatic model assessment for insulin resistance, and other sociodemographic factors. In subgroup analyses, the association between shift work and NWO was more robust in those aged ≥60 years and those working ≥56 hours/week.
Conclusion
Shift work was associated with NWO in community-dwelling Korean adults, independent of age, sex, BMI, and other covariates.

Citations

Citations to this article as recorded by  
  • Impaired Melatonin Secretion, Oxidative Stress and Metabolic Syndrome in Night Shift Work
    Sorina Hohor, Cristina Mandanach, Andreea Maftei, Corina Aurelia Zugravu, Marina Ruxandra Oțelea
    Antioxidants.2023; 12(4): 959.     CrossRef
  • Normal-Weight Obesity and Metabolic Syndrome in Korean Adults: A Population-Based Cross-Sectional Study
    Jeonghyeon Kim, Seamon Kang, Hyunsik Kang
    Healthcare.2023; 11(16): 2303.     CrossRef
  • You Can’t Avoid Shift Work? Then Focus on Body Fat Rather than Weight
    Eun Kyung Lee
    Endocrinology and Metabolism.2022; 37(5): 756.     CrossRef
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Thyroid
Big Data Articles (National Health Insurance Service Database)
Recent Changes in the Incidence of Thyroid Cancer in Korea between 2005 and 2018: Analysis of Korean National Data
Yun Mi Choi, Jiwoo Lee, Mi Kyung Kwak, Min Ji Jeon, Tae Yong Kim, Eun-Gyoung Hong, Won Bae Kim, Won Gu Kim
Endocrinol Metab. 2022;37(5):791-799.   Published online October 11, 2022
DOI: https://doi.org/10.3803/EnM.2022.1533
  • 3,111 View
  • 209 Download
  • 11 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
In this study, we evaluated the recent changes in the standardized, age-specific, stage-specific incidence rates (IRs) of thyroid cancer in Korea and compared them with the incidence data reported by the Surveillance, Epidemiology, and End Results Program.
Methods
The analysis was conducted using the incidence data (2005 to 2018) from the Statistics Korea and Korea Central Cancer Registry.
Results
The age-standardized IR (SIR) of thyroid cancer increased from 24.09 per 100,000 in 2005 to 74.83 in 2012 (annual percent change [APC], 14.5). From 2012 to 2015, the SIR decreased to 42.52 (APC, –17.9) and then remained stable until 2018 (APC, 2.1). This trend was similar in both men and women. Regarding age-specific IRs, the IRs for ages of 30 years and older showed a trend similar to that of the SIR; however, for ages below 30 years, no significant reduction was observed from the vertex of IR in 2015. Regarding stage-specific IRs, the increase was more prominent in those with regional disease (APC, 17.4) than in those with localized disease until 2012; then, the IR decreased until 2015 (APC, –16.1). The average APC from 2005 to 2018 increased in men, those under the age of 30 years, and those with regional disease.
Conclusion
The SIR in Korea peaked in 2012 and decreased until 2015 and then remained stable until 2018. However, in young individuals under the age of 30 years, the IR did not significantly decrease but tended to increase again. In terms of stage-specific IRs, the sharpest increase was seen among those with regional disease.

Citations

Citations to this article as recorded by  
  • Comparison of postoperative pain between transoral and conventional thyroidectomy: a propensity score-matched analysis
    Min Kyu Park, Van Cuong Nguyen, Eugene Kim, Chang Myeon Song, Yong Bae Ji, Jin Hyeok Jeong, Kyung Tae
    Surgical Endoscopy.2024; 38(3): 1512.     CrossRef
  • Contents analysis of thyroid cancer-related information uploaded to YouTube by physicians in Korea: endorsing thyroid cancer screening, potentially leading to overdiagnosis
    EunKyo Kang, HyoRim Ju, Soojeong Kim, Juyoung Choi
    BMC Public Health.2024;[Epub]     CrossRef
  • Bilateral axillo-breast approach robotic total thyroidectomy without isthmectomy: a case report
    Hyeji Kim, Hyeonuk Hwang, Hyungju Kwon
    The Ewha Medical Journal.2024;[Epub]     CrossRef
  • Association between Consumption of Iodine-Rich Foods and Thyroid Cancer Prevalence: Findings from a Large Population-Based Study
    Yu-Jin Kwon, Hye-Sun Lee, Sang-Wook Kang, Ji-Won Lee
    Nutrients.2024; 16(7): 1041.     CrossRef
  • Cost-Utility Analysis of Early Detection with Ultrasonography of Differentiated Thyroid Cancer: A Retrospective Study on a Korean Population
    Han-Sang Baek, Jeonghoon Ha, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, Sungju Kim, Dong-Jun Lim, Chul-Min Kim
    Endocrinology and Metabolism.2024; 39(2): 310.     CrossRef
  • Thyroid Cancer Incidence Among Korean Individuals: A Comparison of South Korea and the United States
    Dohun Kim, Guan Li, Peter K. Moon, Yifei Ma, Soohyun Sim, Sung Y. Park, Minkyung Oh, Uchechukwu C. Megwalu
    The Laryngoscope.2024;[Epub]     CrossRef
  • Cancer and Mortality Risks of Graves’ Disease in South Korea Based on National Data from 2010 to 2019
    Young Ju Choi, Kyungdo Han, Won Kyoung Cho, Min Ho Jung, Byung-Kyu Suh
    Clinical Epidemiology.2023; Volume 15: 535.     CrossRef
  • Survival Comparison of Incidentally Found versus Clinically Detected Thyroid Cancers: An Analysis of a Nationwide Cohort Study
    Shinje Moon, Eun Kyung Lee, Hoonsung Choi, Sue K. Park, Young Joo Park
    Endocrinology and Metabolism.2023; 38(1): 81.     CrossRef
  • Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study
    Jinyoung Kim, Kyungdo Han, Mee Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    The Korean Journal of Internal Medicine.2023; 38(4): 526.     CrossRef
  • Cost-Effectiveness of Active Surveillance Compared to Early Surgery of Small Papillary Thyroid Cancer: A Retrospective Study on a Korean Population
    Han-Sang Baek, Jeonghoon Ha, Kwangsoon Kim, Jaseong Bae, Jeong Soo Kim, Sungju Kim, Dong-Jun Lim, Chulmin Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Long-Term Changes in the Mortality Rates of Thyroid Cancer in Korea: Analysis of Korean National Data from 1985 to 2020
    Yun Mi Choi, Min-Ju Kim, Jiwoo Lee, Mi Kyung Kwak, Min Ji Jeon, Tae Yong Kim, Eun-Gyoung Hong, Won Bae Kim, Won Gu Kim
    Endocrinology and Metabolism.2023; 38(5): 588.     CrossRef
  • Age and Post-Lobectomy Recurrence after Endoscopic or Robotic Thyroid Surgery: A Retrospective Cohort Study of 2348 Papillary Thyroid Carcinoma Patients
    Jin-Seong Cho, Yong-Min Na, Hee Kyung Kim
    Cancers.2023; 15(23): 5506.     CrossRef
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Miscellaneous
DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation
Sudeep Kumar, Jonghwa Jin, Hyeon Young Park, Mi-Jin Kim, Jungwook Chin, Sungwoo Lee, Jina Kim, Jung-Guk Kim, Yeon-Kyung Choi, Keun-Gyu Park
Endocrinol Metab. 2022;37(5):800-809.   Published online September 28, 2022
DOI: https://doi.org/10.3803/EnM.2022.1462
  • 3,321 View
  • 207 Download
  • 1 Web of Science
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AbstractAbstract PDFPubReader   ePub   
Background
Excessive proliferation and migration of vascular smooth muscle cells (VSMCs), which contributes to the development of occlusive vascular diseases, requires elevated mitochondrial oxidative phosphorylation to meet the increased requirements for energy and anabolic precursors. Therefore, therapeutic strategies based on blockade of mitochondrial oxidative phosphorylation are considered promising for treatment of occlusive vascular diseases. Here, we investigated whether DN200434, an orally available estrogen receptor-related gamma inverse agonist, inhibits proliferation and migration of VSMCs and neointima formation by suppressing mitochondrial oxidative phosphorylation.
Methods
VSMCs were isolated from the thoracic aortas of 4-week-old Sprague-Dawley rats. Oxidative phosphorylation and the cell cycle were analyzed in fetal bovine serum (FBS)- or platelet-derived growth factor (PDGF)-stimulated VSMCs using a Seahorse XF-24 analyzer and flow cytometry, respectively. A model of neointimal hyperplasia was generated by ligating the left common carotid artery in male C57BL/6J mice.
Results
DN200434 inhibited mitochondrial respiration and mammalian target of rapamycin complex 1 activity and consequently suppressed FBS- or PDGF-stimulated proliferation and migration of VSMCs and cell cycle progression. Furthermore, DN200434 reduced carotid artery ligation-induced neointima formation in mice.
Conclusion
Our data suggest that DN200434 is a therapeutic option to prevent the progression of atherosclerosis.

Citations

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  • Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells
    Tianying Hong, Xianmei Pan, Han Xu, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia
    Biomedicine & Pharmacotherapy.2023; 163: 114755.     CrossRef
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Brief Report
Adrenal Gland
A Novel Missense PRKAR1A Variant Causes Carney Complex
Boram Kim, Han Na Jang, Kyung Shil Chae, Ho Seop Shin, Yong Hwy Kim, Su Jin Kim, Moon-Woo Seong, Jung Hee Kim
Endocrinol Metab. 2022;37(5):810-815.   Published online October 4, 2022
DOI: https://doi.org/10.3803/EnM.2022.1544
  • 2,130 View
  • 158 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
The Carney complex (CNC) is an autosomal dominant disorder characterized by endocrine and nonendocrine tumors. Loss-of-function variants of protein kinase A regulatory subunit 1 alpha (PRKAR1A) are common causes of CNC. Here, we present the case of a patient with CNC with a novel PRKAR1A missense variant. A 21-year-old woman was diagnosed with CNC secondary to acromegaly and adrenal Cushing syndrome. Genetic analysis revealed a novel missense heterozygous variant of PRKAR1A (c.176A>T). Her relatives, suspected of having CNC, also carried the same variant. RNA analysis revealed that this variant led to nonsense-mediated mRNA decay. In vitro functional analysis of the variant confirmed its role in increasing protein kinase A activity and cyclic adenosine monophosphate levels. This study broadens our understanding of the genetic spectrum of CNC. We suggest that PRKAR1A genetic testing and counseling be recommended for patients with CNC and their families.

Citations

Citations to this article as recorded by  
  • Carney complex: A clinicopathologic study on a single family from several Canadian provinces
    Alexandra Lao, Julio Silva, Brian Chiu, Consolato M. Sergi
    Cardiovascular Pathology.2024; 69: 107599.     CrossRef
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Letter
Thyroid
Re-Increasing Trends in Thyroid Cancer Incidence after a Short Period of Decrease in Korea: Reigniting the Debate on Ultrasound Screening
Chan Kwon Jung, Ja Seong Bae, Young Joo Park
Endocrinol Metab. 2022;37(5):816-818.   Published online October 11, 2022
DOI: https://doi.org/10.3803/EnM.2022.1586
  • 2,194 View
  • 172 Download
  • 5 Web of Science
  • 7 Crossref
PDFPubReader   ePub   

Citations

Citations to this article as recorded by  
  • Bilateral axillo-breast approach robotic total thyroidectomy without isthmectomy: a case report
    Hyeji Kim, Hyeonuk Hwang, Hyungju Kwon
    The Ewha Medical Journal.2024;[Epub]     CrossRef
  • Contents analysis of thyroid cancer-related information uploaded to YouTube by physicians in Korea: endorsing thyroid cancer screening, potentially leading to overdiagnosis
    EunKyo Kang, HyoRim Ju, Soojeong Kim, Juyoung Choi
    BMC Public Health.2024;[Epub]     CrossRef
  • Cost-Utility Analysis of Early Detection with Ultrasonography of Differentiated Thyroid Cancer: A Retrospective Study on a Korean Population
    Han-Sang Baek, Jeonghoon Ha, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, Sungju Kim, Dong-Jun Lim, Chul-Min Kim
    Endocrinology and Metabolism.2024; 39(2): 310.     CrossRef
  • Thyroid Cancer Incidence Among Korean Individuals: A Comparison of South Korea and the United States
    Dohun Kim, Guan Li, Peter K. Moon, Yifei Ma, Soohyun Sim, Sung Y. Park, Minkyung Oh, Uchechukwu C. Megwalu
    The Laryngoscope.2024;[Epub]     CrossRef
  • Survival Comparison of Incidentally Found versus Clinically Detected Thyroid Cancers: An Analysis of a Nationwide Cohort Study
    Shinje Moon, Eun Kyung Lee, Hoonsung Choi, Sue K. Park, Young Joo Park
    Endocrinology and Metabolism.2023; 38(1): 81.     CrossRef
  • Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study
    Jinyoung Kim, Kyungdo Han, Mee Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    The Korean Journal of Internal Medicine.2023; 38(4): 526.     CrossRef
  • Cost-Effectiveness of Active Surveillance Compared to Early Surgery of Small Papillary Thyroid Cancer: A Retrospective Study on a Korean Population
    Han-Sang Baek, Jeonghoon Ha, Kwangsoon Kim, Jaseong Bae, Jeong Soo Kim, Sungju Kim, Dong-Jun Lim, Chulmin Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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Endocrinol Metab : Endocrinology and Metabolism