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Original Article
- Clinical Study
- Subclinical Atherosclerosis in Patients with Cushing Syndrome: Evaluation with Carotid Intima-Media Thickness and Ankle-Brachial Index
- Luigi Petramala, D'Elia Lorenzo, Gino Iannucci, Antonio Concistré, Laura Zinnamosca, Cristiano Marinelli, Giuseppe De Vincentis, Antonio Ciardi, Giorgio De Toma, Claudio Letizia
- Endocrinol Metab. 2015;30(4):488-493. Published online December 31, 2015
- DOI: https://doi.org/10.3803/EnM.2015.30.4.488
- 8,200 View
- 46 Download
- 8 Web of Science
- 9 Crossref
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Abstract
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PubReader Background Cushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. In fact, chronic cortisol excess leads to a constellation of complications, including hypertension, hyperglycemia, adiposity, and thromboembolism. The main vascular alteration associated with CS is atherosclerosis.
Methods Aim of this study was to analyze carotid intima-media thickness (cIMT) and ankle-brachial index (ABI), two surrogate markers of subclinical atherosclerosis in a consecutive series of CS patients, compared to patients with essential hypertension (EH) and health subjects (HS).
Results Patients with CS showed a significant increase (
P <0.05) of cIMT (0.89±0.17 mm) compared to EH (0.81±0.16 mm) and HS (0.75±0.4 mm), with a high prevalence of plaque (23%;P <0.03). Moreover, CS patients showed a mean ABI values (1.07±0.02) significantly lower respect to HS (1.12±0.11;P <0.05), and a higher percentage (20%) of pathological values of ABI (≤0.9;P <0.03).Conclusion In conclusion, we confirmed and extended the data of cIMT in CS, and showed that the ABI represent another surrogate marker of subclinical atherosclerosis in this disease.
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Citations
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Endocrine Practice.2026; 32(3): 329. CrossRef - Endocrine Disorders and Peripheral Arterial Disease – A Series of Reviews
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Endocrine.2020; 70(1): 150. CrossRef - Should Cushing's Syndrome be Considered as a Disease with High Cardiovascular Risk in Relevant Guidelines?
Goran Koracevic, Milan Stojkovic, Dragan Lovic, Milan Pavlovic, Tomislav Kostic, Marija Kutlesic, Sladjana Micic, Maja Koracevic, Milan Djordjevic
Current Vascular Pharmacology.2019; 18(1): 12. CrossRef - Markers of atherosclerosis in patients with Cushing’s syndrome: a meta-analysis of literature studies
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Annals of Medicine.2017; 49(3): 206. CrossRef
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