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1 "Donghwi Park"
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Original Article
Clinical Study
Fasting Plasma Glucose Level Independently Predicts the Mortality of Patients with Coronavirus Disease 2019 Infection: A Multicenter, Retrospective Cohort Study
Min Cheol Chang, Jong-Moon Hwang, Jae-Han Jeon, Sang Gyu Kwak, Donghwi Park, Jun Sung Moon
Endocrinol Metab. 2020;35(3):595-601.   Published online August 26, 2020
DOI: https://doi.org/10.3803/EnM.2020.719
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  • 16 Citations
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Coronavirus disease 2019 (COVID-19) has become a global pandemic, which prompts a consensus for the necessity to seek risk factors for this critical disease. Risk factors affecting mortality of the disease remain elusive. Diabetes and hyperglycemia are known to negatively affect a host’s antiviral immunity. We evaluated the relationship between a history of diabetes, fasting plasma glucose (FPG) levels and mortality among severely ill patients with COVID-19.
Methods
This was a retrospective cohort study that assessed 106 adult inpatients (aged ≥18 years) from two tertiary hospitals in Daegu, South Korea. The participants were transferred to tertiary hospitals because their medical condition required immediate intensive care. The demographic and laboratory data were compared between COVID-19 patients who survived and those who did not.
Results
Compared with the survivor group, age, and the proportions of diabetes, chronic lung disease and FPG were significantly higher in the deceased group. In the Cox proportional hazards regression model for survival analysis, FPG level and age were identified as significant predictors of mortality (P<0.05). The threshold values for predicting high mortality were age >68 years and FPG of 168 mg/dL, respectively. Among those without diabetes, high FPG remained a significant predictor of mortality (P<0.04).
Conclusion
High FPG levels significantly predicted mortality in COVID-19, regardless of a known history of diabetes. These results suggest intensive monitoring should be provided to COVID-19 patients who have a high FPG level.

Citations

Citations to this article as recorded by  
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    Jie Xu, Jianyu Zhao, Liyuan Wu, Xinxin Lu
    Experimental and Clinical Endocrinology & Diabetes.2023; 131(05): 290.     CrossRef
  • Influence of Fasting Plasma Glucose Level on Admission of COVID-19 Patients: A Retrospective Study
    Yingying Zhao, Huichun Xing, Yong Xu
    Journal of Diabetes Research.2022; 2022: 1.     CrossRef
  • The Role of Diabetes and Hyperglycemia on COVID-19 Infection Course—A Narrative Review
    Evangelia Tzeravini, Eleftherios Stratigakos, Chris Siafarikas, Anastasios Tentolouris, Nikolaos Tentolouris
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Novel Glycemic Index Based on Continuous Glucose Monitoring to Predict Poor Clinical Outcomes in Critically Ill Patients: A Pilot Study
    Eun Yeong Ha, Seung Min Chung, Il Rae Park, Yin Young Lee, Eun Young Choi, Jun Sung Moon
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Heterogeneity and Risk of Bias in Studies Examining Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-Analysis
    Abraham Degarege, Zaeema Naveed, Josiane Kabayundo, David Brett-Major
    Pathogens.2022; 11(5): 563.     CrossRef
  • Global, Regional and National Burden of Cancers Attributable to High Fasting Plasma Glucose in 204 Countries and Territories, 1990-2019
    Saeid Safiri, Seyed Aria Nejadghaderi, Nahid Karamzad, Jay S. Kaufman, Kristin Carson-Chahhoud, Nicola Luigi Bragazzi, Mark J. M. Sullman, Mohammad Reza Beyranvand, Mohammad Ali Mansournia, Amir Almasi-Hashiani, Gary S. Collins, Ali-Asghar Kolahi
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • COVID-19 and diabetes—Two giants colliding: From pathophysiology to management
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    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • SARS-CoV-2 omicron variant clearance delayed in breakthrough cases with elevated fasting blood glucose
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    Virology Journal.2022;[Epub]     CrossRef
  • Hyperglycemia is Associated With Increased Mortality in Critically Ill Patients With COVID-19
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    Endocrine Practice.2021; 27(2): 95.     CrossRef
  • The common risk factors for progression and mortality in COVID-19 patients: a meta-analysis
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    Archives of Virology.2021; 166(8): 2071.     CrossRef
  • Dyslipidaemia and mortality in COVID-19 patients: a meta-analysis
    M Zuin, G Rigatelli, C Bilato, C Cervellati, G Zuliani, L Roncon
    QJM: An International Journal of Medicine.2021; 114(6): 390.     CrossRef
  • National early warning score on admission as risk factor for invasive mechanical ventilation in COVID-19 patients
    Min Cheol Chang, Tae Uk Kim, Donghwi Park
    Medicine.2021; 100(19): e25917.     CrossRef
  • Thyroid Hormone Profile and Its Prognostic Impact on the Coronavirus Disease 2019 in Korean Patients
    Jiyeon Ahn, Min Kyung Lee, Jae Hyuk Lee, Seo Young Sohn
    Endocrinology and Metabolism.2021; 36(4): 769.     CrossRef
  • Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: a systematic review and meta-analysis of observational studies
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    BMJ Open.2021; 11(10): e052777.     CrossRef
  • COVID-19 und Diabetes: Folgen der Pandemie
    Baptist Gallwitz, Wolfgang Rathmann
    Deutsches Ärzteblatt Online.2021;[Epub]     CrossRef
  • Incidence of Post-Traumatic Stress Disorder after Coronavirus Disease
    Min Cheol Chang, Donghwi Park
    Healthcare.2020; 8(4): 373.     CrossRef
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