Endocrinology and Metabolism

Original Articles

Diabetes, obesity and metabolism
Plasma C-Peptide Levels and the Continuous Glucose Monitoring-Defined Coefficient of Variation in Risk Prediction for Hypoglycemia in Korean People with Diabetes Having Normal and Impaired Kidney Function: So Yoon Kwon, Jiyun Park, So Hee Park, You-Bin Lee, Gyuri Kim, Kyu Yeon Hur, Jae Hyeon Kim, Sang-Man Jin; Endocrinol Metab. 2025;40(2):268-277. Published online February 27, 2025; DOI: https://doi.org/10.3803/EnM.2024.2083

1,253 View
59 Download
2 Web of Science
2 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
We aimed to investigate the predictive values of plasma C-peptide levels and the continuous glucose monitoring (CGM)-defined coefficient of variation (CV) in risk prediction for hypoglycemia in Korean people with diabetes with normal and impaired kidney function.
Methods
We analyzed data from 1,185 participants diagnosed with type 1 and type 2 diabetes who underwent blinded professional CGM between January 2009 and May 2021 at outpatient clinics. We explored correlations among CGM-defined CV, plasma C-peptide levels, and time below range at <70 and 54 mg/dL across different kidney function categories.
Results
In patients with chronic kidney disease (CKD) stages 1–2 (n=934), 89.3% who had a random plasma C-peptide level higher than 600 pmol/L exhibited a CV of ≤36%. Among those in CKD stage 3 (n=161) with a random plasma C-peptide level exceeding 600 pmol/L, 66.7% showed a CV of ≤36%. In stages 4–5 of CKD (n=90), the correlation between random C-peptide levels and CV was not significant (r=–0.05, P=0.640), including cases with a CV greater than 36% despite very high random plasma C-peptide levels. Random plasma C-peptide levels and CGM-assessed CV significantly predicted hypoglycemia in CKD stages 1–2 and 1–5, respectively.
Conclusion
The established C-peptide criteria in Western populations are applicable to Korean people with diabetes for hypoglycemic risk prediction, unless kidney function is impaired equivalent to CKD stage 3–5. The CGM-defined CV is informative for hypoglycemic risk prediction regardless of kidney function.

Citations

Citations to this article as recorded by

Plasma C-Peptide Level and Continuous Glucose Monitoring-Derived Coefficient of Variation as a Predictable Risk Factor for Hypoglycemia in Koreans with Diabetes
Seung-Hyun Ko
Endocrinology and Metabolism.2025; 40(2): 198. CrossRef
Beneficial Role of Increased Glucose Infusion in Decompensated Type 2 Diabetes Patient
Marie Ticha, Ondrej Sobotka, Pavel Skorepa, Lubos Sobotka
Diabetology.2025; 6(6): 47. CrossRef

Diabetes, obesity and metabolism Big Data Articles (National Health Insurance Service Database)
Time to Insulin Therapy and Severe Hypoglycemia in Korean Adults Initially Diagnosed with Type 2 Diabetes: A Nationwide Study: You-Bin Lee, Kyungdo Han, Bongsung Kim, So Hee Park, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim, Sang-Man Jin; Endocrinol Metab. 2025;40(3):421-433. Published online February 4, 2025; DOI: https://doi.org/10.3803/EnM.2024.2082

1,037 View
37 Download

Abstract PDF Supplementary Material PubReader ePub: Background
We examined the distribution of time to insulin therapy (TIT) post-diabetes diagnosis and the hazard of severe hypoglycemia (SH) according to TIT in Korean adults initially diagnosed with type 2 diabetes (T2D) and who progressed to insulin therapy.
Methods
Using data from the Korean National Health Insurance Service (2002 to 2018), we selected adult incident insulin users (initially diagnosed as T2D) who underwent health examinations between 2009 and 2012. The hazards of SH, recurrent SH, and problematic hypoglycemia were analyzed according to groups categorized using the TIT and clinical risk factors for SH (TIT ≥5 years with risk factors, TIT ≥5 years without risk factors, 3 ≤TIT <5 years, 1 ≤TIT <3 years, and TIT <1 year).
Results
Among 41,637 individuals, 14,840 (35.64%) and 10,587 (25.43%) initiated insulin therapy within <5 and <3 years postdiabetes diagnosis, respectively. During a median 6.53 years, 3,406 SH events occurred. Compared to individuals with TIT ≥5 years and no risk factor for SH, individuals with TIT <3 years had higher outcome hazards in a graded manner (adjusted hazard ratio [95% confidence intervals] for any SH: 1.117 [0.967 to 1.290] in those with 3 ≤TIT <5 years; 1.459 [1.284 to 1.657] in those with 1 ≤ TIT <3 years; and 1.515 [1.309 to 1.754] in those with TIT <1 year). This relationship was more pronounced in the non-obese subpopulation.
Conclusion
Among adults who progressed to insulin therapy after being diagnosed with T2D, a shorter TIT was not uncommon and may predict an increased risk of SH, particularly in non-obese patients.

Brief Report

Adrenal gland
Comparative Analysis of Liquid Chromatography-Tandem Mass Spectrometry and Radioimmunoassay in Determining Plasma Aldosterone Concentration and Plasma Renin Activity for Primary Aldosteronism Screening: So Yoon Kwon, Kyeong-Jin Kim, Soo-Youn Lee, Jae Hyeon Kim; Endocrinol Metab. 2024;39(6):965-969. Published online November 15, 2024; DOI: https://doi.org/10.3803/EnM.2024.1985

1,101 View
48 Download

Abstract PDF Supplementary Material PubReader ePub: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) accurately measures plasma aldosterone concentration (PAC), but its correlation with radioimmunoassay (RIA), equivalent RIA levels, and optimal cutoff for PAC and aldosterone-to-renin ratio (ARR) in primary aldosteronism (PA) screening have not been determined in a Korean population. Our study of 127 patients who underwent diagnostic testing for PA showed that the LC-MS/MS and RIA methods have good correlation, with a mean bias of 29.3% for PAC. An LC-MS/MS PAC level of 11.7 ng/dL was equivalent to an RIA PAC level of 15 ng/dL. Receiver operating characteristic curve analysis showed that an LC-MS/MS PAC level of 10.3 ng/dL and LC-MS/MS ARR level of 20.0 provided sensitivity of 73.1% with a specificity of 57.3% and sensitivity of 92.3% with a specificity of 14.7%, respectively. When the LC-MS/MS method is used for PA screening, an adjustment of cutoff values is necessary.

Original Article

Hypothalamus and pituitary gland
Clinical Characteristics, Diagnosis, and Treatment of Thyroid Stimulating Hormone-Secreting Pituitary Neuroendocrine Tumor (TSH PitNET): A Single-Center Experience: Jung Heo, Yeon-Lim Suh, Se Hoon Kim, Doo-Sik Kong, Do-Hyun Nam, Won-Jae Lee, Sung Tae Kim, Sang Duk Hong, Sujin Ryu, You-Bin Lee, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim, Kyu Yeon Hur; Endocrinol Metab. 2024;39(2):387-396. Published online February 5, 2024; DOI: https://doi.org/10.3803/EnM.2023.1877

4,442 View
134 Download
3 Web of Science
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Thyroid-stimulating hormone (TSH)-secreting pituitary neuroendocrine tumor (TSH PitNET) is a rare subtype of PitNET. We investigated the comprehensive characteristics and outcomes of TSH PitNET cases from a single medical center. Also, we compared diagnostic methods to determine which showed superior sensitivity.
Methods
A total of 17 patients diagnosed with TSH PitNET after surgery between 2002 and 2022 in Samsung Medical Center was retrospectively reviewed. Data on comprehensive characteristics and treatment outcomes were collected. The sensitivities of diagnostic methods were compared.
Results
Seven were male (41%), and the median age at diagnosis was 42 years (range, 21 to 65); the median follow-up duration was 37.4 months. The most common (59%) initial presentation was hyperthyroidism-related symptoms. Hormonal co-secretion was present in four (23%) patients. Elevated serum alpha-subunit (α-SU) showed the greatest diagnostic sensitivity (91%), followed by blunted response at thyrotropin-releasing hormone (TRH) stimulation (80%) and elevated sex hormone binding globulin (63%). Fourteen (82%) patients had macroadenoma, and a specimen of one patient with heavy calcification was negative for TSH. Among 15 patients who were followed up for more than 6 months, 10 (67%) achieved hormonal and structural remission within 6 months postoperatively. A case of growth hormone (GH)/TSH/prolactin (PRL) co-secreting mixed gangliocytoma-pituitary adenoma (MGPA) was discovered.
Conclusion
The majority of the TSH PitNET cases was macroadenoma, and 23% showed hormone co-secretion. A rare case of GH/TSH/PRL co-secreting MGPA was discovered. Serum α-SU and TRH stimulation tests showed great diagnostic sensitivity. Careful consideration is needed in diagnosing TSH PitNET. Achieving remission requires complete tumor resection. In case of nonremission, radiotherapy or medical therapy can improve the long-term remission rate.

Citations

Citations to this article as recorded by

TSH-secreting pituitary adenomas and bone
Marco Losa, Alberto Vassallo, Stefano Frara, Pietro Mortini, Andrea Giustina
Pituitary.2024; 27(6): 752. CrossRef

Review Article

Diabetes, obesity and metabolism
The Benefits Of Continuous Glucose Monitoring In Pregnancy: Jee Hee Yoo, Jae Hyeon Kim; Endocrinol Metab. 2023;38(5):472-481. Published online October 11, 2023; DOI: https://doi.org/10.3803/EnM.2023.1805

13,658 View
511 Download
9 Web of Science
7 Crossref

Abstract PDF PubReader ePub

Previous studies have consistently demonstrated the positive effects of continuous glucose monitoring (CGM) on glycemic outcomes and complications of diabetes in people with type 1 diabetes. Guidelines now consider CGM to be an essential and cost-effective device for managing type 1 diabetes. As a result, insurance coverage for it is available. Evidence supporting CGM continues to grow and expand to broader populations, such as pregnant people with type 1 diabetes, people with type 2 diabetes treated only with basal insulin therapy, and even type 2 diabetes that does not require insulin treatment. However, despite the significant risk of hyperglycemia in pregnancy, which leads to complications in more than half of affected newborns, CGM indications and insurance coverage for those patients are unresolved. In this review article, we discuss the latest evidence for using CGM to offer glycemic control and reduce perinatal complications, along with its cost-effectiveness in pregestational type 1 and type 2 diabetes and gestational diabetes mellitus. In addition, we discuss future prospects for CGM coverage and indications based on this evidence.

Citations

Citations to this article as recorded by

Glucose circadian rhythm assessment in pregnant women for gestational diabetes screening
Rafael Bravo, Kyung Hyun Lee, Sarah A. Nazeer, Jocelyn A. Cornthwaite, Michal Fishel Bartal, Claudia Pedroza
International Journal of Obesity.2025; 49(1): 118. CrossRef
Quality of Life in Women With Gestational Diabetes Mellitus and Treatment Satisfaction Upon Intermittently Scanned Continuous Glucose Monitoring
Sookyung Won, Hyeon Ji Kim, Jee Yoon Park, Kyung Joon Oh, Sung Hee Choi, Hak Chul Jang, Joon Ho Moon
Journal of Korean Medical Science.2025;[Epub] CrossRef
Glucose time in range trajectories during pregnancy and association with adverse perinatal outcomes: a joint latent-class trajectory modeling approach
Sara M. Sauer, Isabel Fulcher, Ayodeji Sanusi, Ashley N. Battarbee
American Journal of Obstetrics & Gynecology MFM.2025; 7(6): 101669. CrossRef
Addressing the Diabetes Tsunami Requires Expanded Access to Diabetes Technologies
Davida F. Kruger, Christopher G. Parkin, Irl B. Hirsch, Grazia Aleppo, Janet B. McGill, Rodolfo J. Galindo, Carol J. Levy, Guillermo E. Umpierrez, George Grunberger, Richard M. Bergenstal
Journal of Diabetes Science and Technology.2025;[Epub] CrossRef
Prise de position d’un groupe d’experts – utilisation de la mesure en continu du glucose chez les patients vivant avec un diabète de type 2 en France
Michael Joubert, Benjamin Bouillet, Gaëtan Prevost, Bruno Vermesse, Helen Mosnier-Pudar, Jean-François Thébaut, Jean-Pierre Riveline, Noëlle Davoust, Bruno Guerci, Laurent Meyer
Médecine des Maladies Métaboliques.2025; 19(4): 331. CrossRef
Wearable devices for glucose monitoring: A review of state-of-the-art technologies and emerging trends
Mohammad Mansour, M. Saeed Darweesh, Ahmed Soltan
Alexandria Engineering Journal.2024; 89: 224. CrossRef
Diagnosis and Treatment of Hyperglycemia in Pregnancy
Sneha Mohan, Aoife M. Egan
Endocrinology and Metabolism Clinics of North America.2024; 53(3): 335. CrossRef

Original Article

Diabetes, obesity and metabolism
Efficacy of Gemigliptin Add-on to Dapagliflozin and Metformin in Type 2 Diabetes Patients: A Randomized, Double-Blind, Placebo-Controlled Study (SOLUTION): Byung Wan Lee, KyungWan Min, Eun-Gyoung Hong, Bon Jeong Ku, Jun Goo Kang, Suk Chon, Won-Young Lee, Mi Kyoung Park, Jae Hyeon Kim, Sang Yong Kim, Keeho Song, Soon Jib Yoo; Endocrinol Metab. 2023;38(3):328-337. Published online June 28, 2023; DOI: https://doi.org/10.3803/EnM.2023.1688

5,805 View
411 Download
2 Web of Science
2 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
This study evaluated the efficacy and safety of add-on gemigliptin in patients with type 2 diabetes mellitus (T2DM) who had inadequate glycemic control with metformin and dapagliflozin.
Methods
In this randomized, placebo-controlled, parallel-group, double-blind, phase III study, 315 patients were randomized to receive either gemigliptin 50 mg (n=159) or placebo (n=156) with metformin and dapagliflozin for 24 weeks. After the 24-week treatment, patients who received the placebo were switched to gemigliptin, and all patients were treated with gemigliptin for an additional 28 weeks.
Results
The baseline characteristics were similar between the two groups, except for body mass index. At week 24, the least squares mean difference (standard error) in hemoglobin A1c (HbA1c) changes was –0.66% (0.07) with a 95% confidence interval of –0.80% to –0.52%, demonstrating superior HbA1c reduction in the gemigliptin group. After week 24, the HbA1c level significantly decreased in the placebo group as gemigliptin was administered, whereas the efficacy of HbA1c reduction was maintained up to week 52 in the gemigliptin group. The safety profiles were similar: the incidence rates of treatment-emergent adverse events up to week 24 were 27.67% and 29.22% in the gemigliptin and placebo groups, respectively. The safety profiles after week 24 were similar to those up to week 24 in both groups, and no new safety findings, including hypoglycemia, were noted.
Conclusion
Add-on gemigliptin was well tolerated, providing comparable safety profiles and superior efficacy in glycemic control over placebo for long-term use in patients with T2DM who had poor glycemic control with metformin and dapagliflozin.

Citations

Citations to this article as recorded by

Efficacy and safety of combination therapy using SGLT2 and DPP4 inhibitors to treat type 2 diabetes: An updated systematic review and meta‐analysis with focus on an Asian subpopulation
Myung Jin Kim, Yun Kyung Cho, Sehee Kim, Jung Yoon Moon, Chang Hee Jung, Woo Je Lee
Diabetes, Obesity and Metabolism.2025;[Epub] CrossRef
Dual add‐on therapy of gemigliptin and dapagliflozin in patients with type 2 diabetes inadequately controlled with metformin alone: The SOLUTION 2 study
Kyung Ah Han, You‐Cheol Hwang, Shin Je Moon, Ho Chan Cho, Hye Jin Yoo, Sung Hee Choi, Suk Chon, Kyoung‐Ah Kim, Tae Nyun Kim, Jun Goo Kang, Cheol‐Young Park, Jong Chul Won, Eunjoo Cho, Jeongyun Kim, Kyong Soo Park
Diabetes, Obesity and Metabolism.2024; 26(9): 3743. CrossRef

Brief Report

Adrenal Gland
Aldosterone Immunoassay-Specific Cutoff Value for Seated Saline Suppression Test for Diagnosing Primary Aldosteronism: So Yoon Kwon, Jiyun Park, So Hee Park, So Hyun Cho, You-Bin Lee, Soo-Youn Lee, Jae Hyeon Kim; Endocrinol Metab. 2022;37(6):938-942. Published online December 6, 2022; DOI: https://doi.org/10.3803/EnM.2022.1535

3,613 View
219 Download
4 Web of Science
4 Crossref

Abstract PDF Supplementary Material PubReader ePub

A seated saline loading test (SLT) using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is one of the most accepted confirmatory tests of primary aldosteronism. However, LC-MS/MS is time-consuming and is not widely available in diagnostic laboratories compared to immunoassay. With immunoassay, it is unknown whether SLT in the seated position is more accurate than that of the supine position, and a cutoff value of post-seated SLT plasma aldosterone concentration (PAC) must be established in the Korean population. Ninety-eight patients underwent SLT in both positions, and post-SLT PAC was measured by LC-MS/MS and radioimmunoassay. We confirmed primary aldosteronism if post-seated SLT PAC by LC-MS/MS exceeded 5.8 ng/dL. The area under the receiver operating characteristic curve was greater for seated than supine SLT (0.928 vs. 0.834, P=0.003). The optimal cutoff value of post-seated SLT by radioimmunoassay was 6.6 ng/dL (sensitivity 83.3%, specificity 92.2%).

Citations

Citations to this article as recorded by

Investigating the cut-off values of captopril challenge test for primary aldosteronism using the novel chemiluminescent enzyme immunoassay method: a retrospective cohort study
Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kengo Kambara, Hiroki Kamada, Sota Oguro, Yuto Yamazaki, Celso E. Gomez-Sanchez, Akihiro Ito, Hironobu Sasano, Kei Takase, Tetsuhiro Tanaka, Hideki Katagiri, Fumitoshi Satoh
Hypertension Research.2024; 47(5): 1362. CrossRef
Usefulness of the Upright Posture Test in the Diagnosis of Primary Aldosteronism
Nada Younes, Matthieu St-Jean, Marie-Josée Desrochers, Eric Therasse, Mathieu Latour, Isabelle Bourdeau, André Lacroix
Journal of the Endocrine Society.2024;[Epub] CrossRef
Screening and treatment of endocrine hypertension focusing on adrenal gland disorders: a narrative review
Seung Min Chung
Journal of Yeungnam Medical Science.2024; 41(4): 269. CrossRef
Comparative Analysis of Liquid Chromatography-Tandem Mass Spectrometry and Radioimmunoassay in Determining Plasma Aldosterone Concentration and Plasma Renin Activity for Primary Aldosteronism Screening
So Yoon Kwon, Kyeong-Jin Kim, Soo-Youn Lee, Jae Hyeon Kim
Endocrinology and Metabolism.2024; 39(6): 965. CrossRef

Original Articles

Thyroid Big Data Articles (National Health Insurance Service Database)
Graves’ Disease and the Risk of End-Stage Renal Disease: A Korean Population-Based Study: Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Hye Ryoun Jang, Bo-Yeon Kim, Chan-Hee Jung, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim; Endocrinol Metab. 2022;37(2):281-289. Published online April 6, 2022; DOI: https://doi.org/10.3803/EnM.2021.1333

7,626 View
154 Download
3 Web of Science
4 Crossref

Abstract PDF PubReader ePub

Background
Hyperthyroidism is associated with an increased glomerular filtration rate (GFR) in the hyperdynamic state, which is reversible after restoring euthyroidism. However, long-term follow-up of renal dysfunction in patients with hyperthyroidism has not been performed.
Methods
This was a retrospective cohort study using the Korean National Health Insurance database and biannual health checkup data. We included 41,778 Graves’ disease (GD) patients and 41,778 healthy controls, matched by age and sex. The incidences of end-stage renal disease (ESRD) were calculated in GD patients and controls. The cumulative dose and duration of antithyroid drugs (ATDs) were calculated for each patient and categorized into the highest, middle, and lowest tertiles.
Results
Among 41,778 GD patients, 55 ESRD cases occurred during 268,552 person-years of follow-up. Relative to the controls, regardless of smoking, drinking, or comorbidities, including chronic kidney disease, GD patients had a 47% lower risk of developing ESRD (hazard ratio [HR], 0.53; 95% confidence interval [CI], 0.37 to 0.76). In particular, GD patients with a higher baseline GFR (≥90 mL/min/1.73 m2; HR, 0.33; 95% CI, 0.11 to 0.99), longer treatment duration (>33 months; HR, 0.31; 95% CI, 0.17 to 0.58) or higher cumulative dose (>16,463 mg; HR, 0.29; 95% CI, 0.15 to 0.57) of ATDs had a significantly reduced risk of ESRD.
Conclusion
This was the first epidemiological study on the effect of GD on ESRD, and we demonstrated that GD population had a reduced risk for developing ESRD.

Citations

Citations to this article as recorded by

Chronic Kidney Disease and Thyroid Hormones
Yuan Cheng, Haofei Hu, Wangyang Li, Sheng Nie, Shiyu Zhou, Yuna Chen, Tao Cao, Hong Xu, Bicheng Liu, Chunbo Chen, Huafeng Liu, Qiongqiong Yang, Hua Li, Yaozhong Kong, Guisen Li, Yan Zha, Ying Hu, Gang Xu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Men
The Journal of Clinical Endocrinology & Metabolism.2024;[Epub] CrossRef
Renal function changes in patients with subclinical hyperthyroidism: a novel postulated mechanism
Magdy Mohamed Allam, Hanaa Tarek El-Zawawy, Tarek Hussein El-Zawawy
Endocrine.2023; 82(1): 78. CrossRef
Effect of Hyperthyroidism on Preventing Renal Insufficiency
Tae Yong Kim
Endocrinology and Metabolism.2022; 37(2): 220. CrossRef
Effects and Clinical Value of Peritoneal Dialysis on Water and Water Balance, Adverse Reactions, Quality of Life, and Clinical Prognosis in Patients with Decompensated Chronic Nephropathy: A Systematic Review and Meta-Analysis
Xichao Wang, Miaomiao Zhang, Na Sun, Wenxiu Chang, Gang Chen
Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef

Adrenal Gland
Contralateral Suppression at Adrenal Venous Sampling Is Associated with Renal Impairment Following Adrenalectomy for Unilateral Primary Aldosteronism: Ye Seul Yang, Seung Hun Lee, Jung Hee Kim, Jee Hee Yoo, Jung Hyun Lee, Seo Young Lee, A Ram Hong, Dong-Hwa Lee, Jung-Min Koh, Jae Hyeon Kim, Sang Wan Kim; Endocrinol Metab. 2021;36(4):875-884. Published online August 11, 2021; DOI: https://doi.org/10.3803/EnM.2021.1047

6,953 View
167 Download
8 Web of Science
8 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Adrenal venous sampling (AVS) is performed to distinguish the subtype of primary aldosteronism (PA). The clinical implication of contralateral suppression (CS; aldosterone/cortisol_nondominantperipheral) at AVS remains unclear. We aimed to investigate the clinical significance of CS and its impact on postoperative outcomes after unilateral adrenalectomy.
Methods
In this retrospective observational multi-center study, we analyzed PA patients who underwent both successful adrenocorticotropin hormone-stimulated AVS and unilateral adrenalectomy. Successful cannulation was defined as the selectivity index (cortisol_adrenal/ cortisol_peripheral) ≥3. Clinical and biochemical outcomes after unilateral adrenalectomy were evaluated based on the international Primary Aldosteronism Surgical Outcome consensus.
Results
Among 263 patients analyzed, 247 had CS (93.9%). Patients with CS had lower serum potassium levels, higher plasma aldosterone concentration, higher aldosterone-to-renin ratio (ARR), and larger adenoma size than those without CS. Those with CS showed significantly higher lateralization index than those without CS (P<0.001). Although postoperative blood pressure and ARR significantly decreased in those with CS, clinical and biochemical outcomes were comparable in both groups. When the cut-off value of age was determined using receiver operating characteristic (ROC) analysis, patients aged ≥50 years old with contralateral suppression index (CSI; the ratio between aldosterone/cortisol_nondominant and aldosterone/cortisol_peripheral) ≤0.26 had greater odds ratio (6.43; 95% confidence interval, 1.30 to 31.69) of incident chronic kidney disease than those aged <50 years with CSI >0.26 after adjusting for other factors.
Conclusion
CS may not predict postoperative clinical and biochemical outcomes in subjects with unilateral aldosterone excess, but it is associated with postsurgical deterioration of renal function in subjects over 50 years with CSI ≤0.26.

Citations

Citations to this article as recorded by

Treatment decision based on unilateral index from nonadrenocorticotropic hormone-stimulated and adrenocorticotropic hormone-stimulated adrenal vein sampling in primary aldosteronism
Xizi Zhang, Xiaoyu Shu, Feifei Wu, Jun Yang, Qingfeng Cheng, Zhipeng Du, Ying Song, Yi Yang, Jinbo Hu, Yue Wang, Qifu Li, Shumin Yang
Journal of Hypertension.2024; 42(3): 450. CrossRef
Correlation of Histopathologic Subtypes of Primary Aldosteronism with Clinical Phenotypes and Postsurgical Outcomes
Chang Ho Ahn, You-Bin Lee, Jae Hyeon Kim, Young Lyun Oh, Jung Hee Kim, Kyeong Cheon Jung
The Journal of Clinical Endocrinology & Metabolism.2024; 109(8): e1582. CrossRef
Development of a multivariate model predictive of post-adrenalectomy renal function decline in patients with primary aldosteronism: a large-cohort single-center study
Wenhao Lin, Juping Zhao, Chen Fang, Wei He, Xin Huang, Fukang Sun, Jun Dai
World Journal of Urology.2024;[Epub] CrossRef
Prognostic value of contralateral suppression on kidney function after surgery in patients with primary aldosteronism
Nathalie Voss, Sara Mørup, Caroline Clausen, Claus larsen Feltoft, Jan Viberg Jepsen, Mads Hornum, Mikkel Andreassen, Jesper Krogh
Clinical Endocrinology.2023; 98(3): 306. CrossRef
Factors Predicting Long-term Estimated Glomerular Filtration Rate Decrease, a Reliable Indicator of Renal Function After Adrenalectomy in Primary Aldosteronism
Qiyu He, Zhimin Tan, Yu Liu, Liang Zhou
Endocrine Practice.2023; 29(3): 199. CrossRef
Prognostic value of contralateral suppression for remission after surgery in patients with primary aldosteronism
Sara Mørup, Nathalie Voss, Caroline Clausen, Claus Larsen Feltoft, Mikkel Andreassen, Jesper Krogh
Clinical Endocrinology.2022; 96(6): 793. CrossRef
Contralateral Suppression at Adrenal Venous Sampling Is Associated with Renal Impairment Following Adrenalectomy for Unilateral Primary Aldosteronism (Endocrinol Metab 2021;36:875-84, Ye Seul Yang et al.)
Zhimin Tan, Qiyu He, Liang Zhou
Endocrinology and Metabolism.2022; 37(6): 951. CrossRef
Contralateral Suppression at Adrenal Venous Sampling Is Associated with Renal Impairment Following Adrenalectomy for Unilateral Primary Aldosteronism (Endocrinol Metab 2021;36:875-84, Ye Seul Yang et al.)
Ye Seul Yang, Sang Wan Kim
Endocrinology and Metabolism.2022; 37(6): 953. CrossRef

Brief Report

Adrenal Gland
Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma: Jiyeon Ahn, Ji Yun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Soo-Youn Lee, Jae Hyeon Kim; Endocrinol Metab. 2021;36(3):697-701. Published online June 1, 2021; DOI: https://doi.org/10.3803/EnM.2020.925

8,664 View
229 Download
5 Web of Science
5 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the diagnostic accuracy of these new methods and the diagnostic cutoff values have not been evaluated.
Methods
This is a retrospective study of 595 subjects, including 71 PPGL cases and 524 controls. PPGL was based on pathological confirmation. Subjects with no evidence of PPGL over 2 years were included in the control group.
Results
Urinary free metanephrines yielded similar area under the curve (AUC) to urinary fractionated metanephrines and plasma free metanephrines. However, urinary free normetanephrine yielded a better AUC than did urinary fractionated normetanephrine. The optimal cutoff for urinary free metanephrine and normetanephrine corrected for urinary creatinine yielded 97.2% sensitivity and 98.1% specificity.
Conclusion
Urinary free metanephrines are a reliable method for diagnosing PPGL in Asian populations compared with existing biochemical methods.

Citations

Citations to this article as recorded by

Advancements in understanding the molecular mechanisms and clinical implications of Von Hippel-Lindau syndrome: A comprehensive review
Yaochun Wang, Jingzhuo Song, Shuxing Zheng, Shuhong Wang
Translational Oncology.2025; 51: 102193. CrossRef
The role of the adrenalectomy in the management of pheochromocytoma: the experience of a Portuguese referral center
Inês Costa Carvalho, Miguel V. B. Machado, João P. Morais, Filipa Carvalho, Elisabete Barbosa, José Barbosa
Endocrine.2024; 86(1): 409. CrossRef
Laparoscopic Resection of Para-Aortic Mass at the Aortic Bifurcation: An Atypical Presentation of a Tailgut Cyst
Andy Wang, Jiddu A Guart, Danielle Li, Trenton Taros, Hongyi Cui
Cureus.2024;[Epub] CrossRef
Biochemical Assessment of Pheochromocytoma and Paraganglioma
Graeme Eisenhofer, Christina Pamporaki, Jacques W M Lenders
Endocrine Reviews.2023; 44(5): 862. CrossRef
Adrenal bleeding due to pheochromocytoma - A call for algorithm
Ewelina Rzepka, Joanna Kokoszka, Anna Grochowska, Magdalena Ulatowska-Białas, Martyna Lech, Marta Opalińska, Elwira Przybylik-Mazurek, Aleksandra Gilis-Januszewska, Alicja Hubalewska-Dydejczyk
Frontiers in Endocrinology.2022;[Epub] CrossRef

Special Article

Adrenal gland
Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force: Eu Jeong Ku, Kyoung Jin Kim, Jung Hee Kim, Mi Kyung Kim, Chang Ho Ahn, Kyung Ae Lee, Seung Hun Lee, You-Bin Lee, Kyeong Hye Park, Yun Mi Choi, Namki Hong, A Ram Hong, Sang-Wook Kang, Byung Kwan Park, Moon-Woo Seong, Myungshin Kim, Kyeong Cheon Jung, Chan Kwon Jung, Young Seok Cho, Jin Chul Paeng, Jae Hyeon Kim, Ohk-Hyun Ryu, Yumie Rhee, Chong Hwa Kim, Eun Jig Lee; Endocrinol Metab. 2021;36(2):322-338. Published online April 6, 2021; DOI: https://doi.org/10.3803/EnM.2020.908

14,090 View
809 Download
12 Web of Science
15 Crossref

Abstract PDF PubReader ePub

Pheochromocytoma and paraganglioma (PPGLs) are rare catecholamine-secreting neuroendocrine tumors but can be life-threatening. Although most PPGLs are benign, approximately 10% have metastatic potential. Approximately 40% cases are reported as harboring germline mutations. Therefore, timely and accurate diagnosis of PPGLs is crucial. For more than 130 years, clinical, molecular, biochemical, radiological, and pathological investigations have been rapidly advanced in the field of PPGLs. However, performing diagnostic studies to localize lesions and detect metastatic potential can be still challenging and complicated. Furthermore, great progress on genetics has shifted the paradigm of genetic testing of PPGLs. The Korean PPGL task force team consisting of the Korean Endocrine Society, the Korean Surgical Society, the Korean Society of Nuclear Medicine, the Korean Society of Pathologists, and the Korean Society of Laboratory Medicine has developed this position statement focusing on the comprehensive and updated diagnosis for PPGLs.

Citations

Citations to this article as recorded by

A Prospective Comparative Study of 18F-FDOPA PET/CT Versus 123I-MIBG Scintigraphy With SPECT/CT for the Diagnosis of Pheochromocytoma and Paraganglioma
Changhwan Sung, Hyo Sang Lee, Dong Yun Lee, Yong-il Kim, Jae Eun Kim, Sang Ju Lee, Seung Jun Oh, Tae-Yon Sung, Yu-Mi Lee, Young Hoon Kim, Beom-Jun Kim, Jung-Min Koh, Seung Hun Lee, Jin-Sook Ryu
Clinical Nuclear Medicine.2024; 49(1): 27. CrossRef
Preoperative prediction of metastatic pheochromocytoma and paraganglioma using clinical, genetic, and biochemical markers: A cohort study
Seung Shin Park, Chang Ho Ahn, Seunghoo Lee, Woochang Lee, Won Woong Kim, Yu‐Mi Lee, Su Jin Kim, Tae‐Yon Sung, Kyu Eun Lee, Jung Hee Kim, Seung Hun Lee, Jung‐Min Koh
Journal of Internal Medicine.2024; 296(1): 68. CrossRef
Germline Mutations and Phenotypic Associations in Korean Patients With Pheochromocytoma and Paraganglioma: A Multicenter Study and Literature Review
Kwan Hoon Jo, Jaewoong Lee, Jaeeun Yoo, Hoon Seok Kim, Eun Sook Kim, Je Ho Han, Yi Sun Jang, Jae-Seung Yun, Jang Won Son, Soon Jib Yoo, Seung Hwan Lee, Dong Jun Lim, Hyuk-Sang Kwon, Seungok Lee, Sungdae Moon, Myungshin Kim
Annals of Laboratory Medicine.2024; 44(6): 591. CrossRef
Raccomandazioni della lista del GdS-Endocrinologia e Malattie del Metabolismo SIPMeL-Choosing wisely: tiroide, anticorpi anti-tiroide, cortisolo, surrene, vitamina D: aggiornamento 2024
Romolo M. DORIZZI, Vincenzo BRESCIA, Marina VITILLO, Ottavia PORZIO, Federica D’AURIZIO
La Rivista Italiana della Medicina di Laboratorio.2024;[Epub] CrossRef
Screening and treatment of endocrine hypertension focusing on adrenal gland disorders: a narrative review
Seung Min Chung
Journal of Yeungnam Medical Science.2024; 41(4): 269. CrossRef
Clinical and epidemiological characteristics of patients with pheochromocytoma and retroperitoneal paraganglioma
D. V. Rebrova, N. V. Vorokhobina
Meditsinskiy sovet = Medical Council.2024; (16): 206. CrossRef
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association
A Ram Hong, Ho-Cheol Kang
Endocrinology and Metabolism.2023; 38(2): 175. CrossRef
Lesion-based indicators predict long-term outcomes of pheochromocytoma and paraganglioma– SIZEPASS
Helena Hanschell, Salvador Diaz-Cano, Alfredo Blanes, Nadia Talat, Gabriele Galatá, Simon Aylwin, Klaus Martin Schulte
Frontiers in Endocrinology.2023;[Epub] CrossRef
Interleukin-6-producing paraganglioma as a rare cause of systemic inflammatory response syndrome: a case report
Yin Young Lee, Seung Min Chung
Journal of Yeungnam Medical Science.2023; 40(4): 435. CrossRef
(Extremely rare intrapericardial location of paraganglioma)
Jaroslav Zajíc, Aleš Mokráček, Ladislav Pešl, Jiří Haniš, Dita Schaffelhoferová
Cor et Vasa.2023; 65(4): 692. CrossRef
A Case of Von Hippel-Lindau Disease With Recurrence of Paraganglioma and No Other Associated Symptoms: The Importance of Genetic Testing and Establishing Follow-Up Policies
Naoki Okada, Akihiro Shioya, Sumihito Togi, Hiroki Ura, Yo Niida
Cureus.2023;[Epub] CrossRef
KSNM60 in Nuclear Endocrinology: from the Beginning to the Future
Chae Moon Hong, Young Jin Jeong, Hae Won Kim, Byeong-Cheol Ahn
Nuclear Medicine and Molecular Imaging.2022; 56(1): 17. CrossRef
Change of Computed Tomography-Based Body Composition after Adrenalectomy in Patients with Pheochromocytoma
Yousun Ko, Heeryoel Jeong, Seungwoo Khang, Jeongjin Lee, Kyung Won Kim, Beom-Jun Kim
Cancers.2022; 14(8): 1967. CrossRef
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: a Position Statement from the Korean Thyroid Association
A Ram Hong, Hwa Young Ahn, Bu Kyung Kim, Seong Hee Ahn, So Young Park, Min-Hee Kim, Jeongmin Lee, Sun Wook Cho, Ho-Cheol Kang
International Journal of Thyroidology.2022; 15(1): 1. CrossRef
Pheochromocytoma with Retroperitoneal Metastasis: A Case Report
建新崔
Advances in Clinical Medicine.2021; 11(05): 2239. CrossRef

Original Article

Clinical Study
Association of Body Mass Index with the Risk of Incident Type 2 Diabetes, Cardiovascular Disease, and All-Cause Mortality: A Community-Based Prospective Study: Ji Cheol Bae, Nam H. Cho, Jae Hyeon Kim, Kyu Yeon Hur, Sang-Man Jin, Moon-Kyu Lee; Endocrinol Metab. 2020;35(2):416-424. Published online June 24, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.2.416

10,848 View
192 Download
13 Web of Science
14 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Type 2 diabetes and cardiovascular disease (CVD) are the most important sequelae of obesity and the leading cause of death. We evaluated the association between body mass index (BMI) and the risk of incident type 2 diabetes, CVD, and all-cause mortality in a prospective study of a Korean population.
Methods
The shapes of the associations were modeled by restricted cubic splines regression analysis. After categorizing all subjects (n=8,900) into octiles based on their BMI levels, we estimated the hazard ratio (HR) for the association of categorized BMI levels with the risk of incident CVD and type 2 diabetes using a Cox’s proportional hazard analysis.
Results
The mean age of participants was 52 years and 48% were men. Of the subjects at baseline, 39.0% of men and 45.6% of women were classified as obese (BMI ≥25 kg/m²). Over a mean follow-up of 8.1 years, CVD events occurred in 509 participants; 436 died; and 1,258 subjects developed type 2 diabetes. The increased risk of incident diabetes began to be significant at BMI 23 to 24 kg/m² in both sexes (HR, 1.8). For CVD events, the risk began to increase significantly at BMI 26 to 28 kg/m² (HR, 1.6). We found a reverse J-shaped relationship between BMI and all-cause mortality, with an increased risk among individuals with BMI values in lower range (BMI <21 kg/m²).
Conclusion
These results suggest that the BMI cut-off points for observed risk were varied depending on the diseases and that the BMI classification of obesity need to be revised to reflect differential risk of obesity-related diseases.

Citations

Citations to this article as recorded by

Association of obesity with cardiovascular disease in the absence of traditional risk factors
Hui Luo, Yesong Liu, Xue Tian, Yuhan Zhao, Lulu Liu, Zemeng Zhao, Lili Luo, Yanmin Zhang, Xiaozhong Jiang, Yeqiang Liu, Yanxia Luo, Anxin Wang
International Journal of Obesity.2024; 48(2): 263. CrossRef
Clinical characteristics and degree of cardiovascular risk factor control in patients with newly-diagnosed type 2 diabetes in Catalonia
Anna Ramírez-Morros, Josep Franch-Nadal, Jordi Real, Queralt Miró-Catalina, Magdalena Bundó, Bogdan Vlacho, Didac Mauricio
Frontiers in Endocrinology.2024;[Epub] CrossRef
Research Progress on the Association and Mechanism between Obesity and Prostate Cancer
娜古丽·艾海提热
Advances in Clinical Medicine.2024; 14(04): 1941. CrossRef
Assessing the health and economic burden of obesity-related complications in East-Asian populations: implementation of risk equations in the Core Obesity Model for Japan and model validation
Ichiro Tatsuno, Laetitia Gerlier, Anamaria-Vera Olivieri, James Baker-Knight, Mark Lamotte
BMJ Public Health.2024; 2(1): e000302. CrossRef
Metabolic status indicators and influencing factors in non-obese, non-centrally obese nonalcoholic fatty liver disease
Zhipeng Huang, Donghong Wei, Xueping Yu, Zicheng Huang, Yijie Lin, Wenji Lin, Zhijun Su, Jianjia Jiang
Medicine.2023; 102(6): e32922. CrossRef
Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining
Xin Luo, Jijia Sun, Hong Pan, Dian Zhou, Ping Huang, Jingjing Tang, Rong Shi, Hong Ye, Ying Zhao, An Zhang, Yee Gary Ang
PLOS ONE.2023; 18(8): e0289749. CrossRef
Differential Impact of Obesity on the Risk of Diabetes Development in Two Age Groups: Analysis from the National Health Screening Program
Tae Kyung Yoo, Kyung-Do Han, Yang-Hyun Kim, Ga Eun Nam, Sang Hyun Park, Eun-Jung Rhee, Won-Young Lee
Diabetes & Metabolism Journal.2023; 47(6): 846. CrossRef
Relationship between advanced lung cancer inflammation index and long-term all-cause, cardiovascular, and cancer mortality among type 2 diabetes mellitus patients: NHANES, 1999–2018
Yaying Chen, Mengqian Guan, Ruiqi Wang, Xuewen Wang
Frontiers in Endocrinology.2023;[Epub] CrossRef
Body mass index at baseline directly predicts new-onset diabetes and to a lesser extent incident cardio-cerebrovascular events, but has a J-shaped relationship to all-cause mortality
Yoon-Jong Bae, Sang-Jun Shin, Hee-Taik Kang
BMC Endocrine Disorders.2022;[Epub] CrossRef
Association of Shift Work with Normal-Weight Obesity in Community-Dwelling Adults
Chul Woo Ahn, Sungjae Shin, Seunghyun Lee, Hye-Sun Park, Namki Hong, Yumie Rhee
Endocrinology and Metabolism.2022; 37(5): 781. CrossRef
The Prognostic Value of Combined Status of Body Mass Index and Psychological Well-Being for the Estimation of All-Cause and CVD Mortality Risk: Results from a Long-Term Cohort Study in Lithuania
Dalia Lukšienė, Abdonas Tamosiunas, Ricardas Radisauskas, Martin Bobak
Medicina.2022; 58(11): 1591. CrossRef
The Relationship between Body Mass Index and Incident Diabetes Mellitus in Chinese Aged Population: A Cohort Study
M. L. Tang, Y. Q. Zhou, A. Q. Song, J. L. Wang, Y. P. Wan, R. Y. Xu, Carol Forsblom
Journal of Diabetes Research.2021; 2021: 1. CrossRef
Correlation between adiponectin level and the degree of fibrosis in patients with non-alcoholic fatty liver disease
Manal Sabry Mohamed, Tarek Mohammed Youssef, Esraa Ebrahim Abdullah, Ahmed Elmetwally Ahmed
Egyptian Liver Journal.2021;[Epub] CrossRef
Obesity Measures as Predictors of Type 2 Diabetes and Cardiovascular Diseases among the Jordanian Population: A Cross-Sectional Study
Hana Alkhalidy, Aliaa Orabi, Khadeejah Alnaser, Islam Al-Shami, Tamara Alzboun, Mohammad D. Obeidat, Dongmin Liu
International Journal of Environmental Research and Public Health.2021; 18(22): 12187. CrossRef

Namgok Lecture 2019

Obesity and Metabolism
Impact of Skeletal Muscle Mass on Metabolic Health: Gyuri Kim, Jae Hyeon Kim; Endocrinol Metab. 2020;35(1):1-6. Published online March 19, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.1.1

19,395 View
433 Download
89 Web of Science
94 Crossref

Abstract PDF PubReader ePub

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diseases, including metabolic syndrome and non-alcoholic fatty liver disease.

Citations

Citations to this article as recorded by

Dietary Calcium-to-Phosphorous Ratio, Metabolic Risk Factors and Lipid Accumulation Product, Skeletal Muscle Mass, and Visceral Fat Area Among Healthy Young Individuals
Xuanshang Jin, Xiangchuan Jin, Wen Guan, Maolin Tang
International Journal of Sport Nutrition and Exercise Metabolism.2025; 35(1): 43. CrossRef
Risk factors for metabolic syndrome are associated with low handgrip strength in people with HIV
Izabella Bernardes Araujo, Camila Ferreira Silva, Eduardo Vignoto Fernandes, Morganna Alves Siqueira, Marília Brasil Xavier, Luiz Fernando Gouvêa-e-Silva
Sport Sciences for Health.2025; 21(1): 465. CrossRef
Changes in muscle performance among older adults with myeloid malignancies engaging in a mobile health (mHealth) exercise intervention: a single arm pilot study
Marielle Jensen-Battaglia, Po-Ju Lin, Chandrika Sanapala, Erin E. Watson, Jason H. Mendler, Jane Liesveld, Ying Wang, Elisabeth Hayward, Marissa LoCastro, Soroush Mortaz, Richard F. Dunne, Karen Mustian, Kah Poh Loh
BMC Geriatrics.2025;[Epub] CrossRef
The Use of SGLT-2 Inhibitors and GLP-1RA in Frail Older People with Diabetes: A Personalised Approach Is Required
Alan J. Sinclair, Ahmed H. Abdelhafiz
Metabolites.2025; 15(1): 49. CrossRef
Effects of 12-month physical and cognitive training on sarcopenia determinants in older adults: a subgroup analysis of a randomised clinical trial
Onni Oskari Hämäläinen, Tiina Marketta Savikangas, Anna-Katriina Tirkkonen, Markku Juhani Alén, Arto Jorma Hautala, Sarianna Sipilä
Aging Clinical and Experimental Research.2025;[Epub] CrossRef
Preliminary Evidence Suggests That a 12-Week Treatment with Tirzepatide Plus Low-Energy Ketogenic Therapy Is More Effective than Its Combination with a Low-Calorie Diet in Preserving Fat-Free Mass, Muscle Strength, and Resting Metabolic Rate in Patients w
Luigi Schiavo, Biagio Santella, Monica Mingo, Gianluca Rossetti, Marcello Orio, Luigi Cobellis, Attilio Maurano, Antonio Iannelli, Vincenzo Pilone
Nutrients.2025; 17(7): 1216. CrossRef
Effects of protein supplementation on muscle mass, muscle strength, and physical performance in older adults with physical inactivity: a systematic review and meta-analysis
Liying Zhang, Gongxiang Liu, Xiaoli Huang, Fuqian He
BMC Geriatrics.2025;[Epub] CrossRef
Growth hormone–deficient Ames dwarf mice resist sarcopenia and exhibit enhanced endurance running performance at 24 months
Matthew J. Johnston, Sharlene G. Rakoczy, LaDora V. Thompson, Holly M. Brown-Borg
GeroScience.2025; 47(3): 4827. CrossRef
Effects of a Combination of Morus bombycis Koidz. and Angelica keiskei Extracts on Muscle Atrophy in an Aging Mouse Model
Hyun Hwangbo, Min Yeong Kim, Seon Yeong Ji, Da Hye Kim, Jae Hyun Yoon, Seong Un Jeong, Tae Hee Kim, Yung Hyun Choi
Journal of the Korean Society of Food Science and Nutrition.2025; 54(3): 218. CrossRef
Association between the skeletal muscle-to-visceral fat ratio and kidney stones: a cross-sectional study
Yuan-Zhuo Du, Jia-Qing Yang, Jian Tang, Chi-Teng Zhang, Yi-Fu Liu
Frontiers in Nutrition.2025;[Epub] CrossRef
Relationship between bmi and glomerular filtration rate in a large cohort initiating a weight loss program: differential contributions of fat mass, fat-free mass, and abdominal fat compartments
Alessandro Leone, Francesca Menichetti, Laila Vignati, Federica Sileo, Ramona De Amicis, Andrea Foppiani, Simona Bertoli, Alberto Battezzati
Nutrition Journal.2025;[Epub] CrossRef
Sarcopenic obesity in the Asia-Pacific region: Epidemiology, risk factors, and management
Chun-Feng Huang, Chih-Hsing Wu
Osteoporosis and Sarcopenia.2025;[Epub] CrossRef
Muscle strength changes and physical activity during gender‐affirming hormone therapy: A systematic review
Mathilde Kamp Nørlund, Louise Lehmann Christensen, Marianne Skovsager Andersen, Tine Taulbjerg Kristensen, Jan Frystyk, Jonas Mathiesen, Jakob Lindberg Nielsen, Dorte Glintborg
Andrology.2025;[Epub] CrossRef
The relationship between cognitive function and muscle mass in older adults: a longitudinal study based on CLHLS
Yin Shi, Yu Zhang, Xinyu Yang, Jiali Yang, Shilang Wang, YanFang Hong
Frontiers in Psychiatry.2025;[Epub] CrossRef
Sex differences in the association between dual‐energy x‐ray absorptiometry‐measured body composition and periodontitis
Peijun Zhu, An Li, Qingqing Cai, Yuntao Chen, Yang Liu, Harriët Jager‐Wittenaar, Geerten‐Has E. Tjakkes, Shulan Xu
Journal of Periodontology.2024; 95(3): 219. CrossRef
Advances in the treatment of functional male hypogonadism
Giovanni Corona, Giulia Rastrelli, Clotilde Sparano, Linda Vignozzi, Alessandra Sforza, Mario Maggi
Expert Review of Endocrinology & Metabolism.2024; 19(2): 163. CrossRef
Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors
Min Wang, Yang Ou, Xiang-Lian Yuan, Xiu-Fang Zhu, Ben Niu, Zhuang Kang, Bing Zhang, Anwar Ahmed, Guo-Qiang Xing, Heng Su
World Journal of Diabetes.2024; 15(1): 53. CrossRef
The Vicious Cycle of Type 2 Diabetes Mellitus and Skeletal Muscle Atrophy: Clinical, Biochemical, and Nutritional Bases
Jose M. Lopez-Pedrosa, Maria Camprubi-Robles, German Guzman-Rolo, Andres Lopez-Gonzalez, Jose Manuel Garcia-Almeida, Alejandro Sanz-Paris, Ricardo Rueda
Nutrients.2024; 16(1): 172. CrossRef
FGF21 Induces Skeletal Muscle Atrophy and Increases Amino Acids in Female Mice: A Potential Role for Glucocorticoids
Karlton R Larson, Devi Jayakrishnan, Karla A Soto Sauza, Michael L Goodson, Aki T Chaffin, Arik Davidyan, Suraj Pathak, Yanbin Fang, Diego Gonzalez Magaña, Benjamin F Miller, Karen K Ryan
Endocrinology.2024;[Epub] CrossRef
Sarcopenic Obesity and Cardiovascular Disease: An Overlooked but High-Risk Syndrome
Saeid Mirzai, Salvatore Carbone, John A. Batsis, Stephen B. Kritchevsky, Dalane W. Kitzman, Michael D. Shapiro
Current Obesity Reports.2024; 13(3): 532. CrossRef
Mortality risk relationship using standard categorized BMI or knee-height based BMI – does the overweight/lower mortality paradox hold true?
Nivetha Natarajan Gavriilidou, Mats Pihlsgård, Sölve Elmståhl, Henrik Ekström
Aging Clinical and Experimental Research.2024;[Epub] CrossRef
Gromwell (Lithospermum erythrorhizon) Attenuates High-Fat-Induced Skeletal Muscle Wasting by Increasing Protein Synthesis and Mitochondrial Biogenesis
Ji-Sun Kim, Hyunjung Lee, Ahyoung Yoo, Hang Yeon Jeong, Chang Hwa Jung, Jiyun Ahn, Tae-Youl Ha
Journal of Microbiology and Biotechnology.2024; 34(3): 495. CrossRef
L-shaped association between lean body mass to visceral fat mass ratio with hyperuricemia: a cross-sectional study
Longti Li, Ya Shao, Huiqin Zhong, Yu Wang, Rong Zhang, Boxiong Gong, Xiaoxv Yin
Lipids in Health and Disease.2024;[Epub] CrossRef
Effect of COVID‐19 pandemic on bioimpedance health indicators in young adults
Darina Falbová, Radoslav Beňuš, Simona Sulis, Lenka Vorobeľová
American Journal of Human Biology.2024;[Epub] CrossRef
Sex difference in skeletal muscle mass in relation to metabolic dysfunction-associated steatotic liver disease: a propensity score matching study
Da-Hye Son, Yu-Jin Kwon, Jun-Hyuk Lee
The Journal of nutrition, health and aging.2024; 28(6): 100270. CrossRef
Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle
Colleen S. Deane, Jake Cox, Philip J. Atherton
Frontiers in Nutrition.2024;[Epub] CrossRef
Molecular mechanism of skeletal muscle loss and its prevention by natural resources
Jin Tae Kim, Dong Hyeon Jeon, Hong Jin Lee
Food Science and Biotechnology.2024; 33(15): 3387. CrossRef
Why you should not skip tailored exercise interventions when using incretin mimetics for weight loss
Katharina Gross, Christian Brinkmann
Frontiers in Endocrinology.2024;[Epub] CrossRef
The Effects of Blood Flow Restriction Aerobic Exercise on Body Composition, Muscle Strength, Blood Biomarkers, and Cardiovascular Function: A Narrative Review
Chaeeun Cho, Sewon Lee
International Journal of Molecular Sciences.2024; 25(17): 9274. CrossRef
Low muscle mass is associated with efficacy of biologics in Crohn's disease
Ye Fang, Luyan Fang, Mengqian Ye, Hanyue Jiang, Xinyu Long, Haoxuan Zhang, Qianqian Zhang, Daopo Lin, Xiaoxiao Shao
Clinical Nutrition.2024; 43(10): 2354. CrossRef
Pre-Transplant Dual-Energy X-ray Absorptiometry (DXA)-Derived Body Composition Measures as Predictors of Treatment Outcomes and Early Post-Transplant Complications in Patients with Multiple Myeloma (MM) Treated with Autologous Hematopoietic Stem Cell Tran
Paula Jabłonowska-Babij, Diana Jędrzejuk, Maciej Majcherek, Agnieszka Szeremet, Magdalena Karasek, Bartłomiej Kuszczak, Krzysztof Kujawa, Milena Sitkiewicz, Marcin Landwójtowicz, Tomasz Wróbel, Maciej Tomasiewicz, Anna Czyż
Journal of Clinical Medicine.2024; 13(19): 5987. CrossRef
circAGO3 facilitates NF-κB pathway-mediated inflammatory atrophy in chicken skeletal muscle via the miR-34b-5p/TRAF3 axis
Xiyu Zhao, Shuyue Tang, Zhenyu Lei, Xiaoxu Shen, Yao Zhang, Shunshun Han, Huadong Yin, Can Cui
International Journal of Biological Macromolecules.2024; 283: 137614. CrossRef
Analyzing body composition in living kidney donors: impact on post-transplant kidney function
Evelien E. Quint, Lisa B. Westenberg, Gertrude J. Nieuwenhuijs-Moeke, Eva A. N. van den Broek, Marcel Zorgdrager, Alain R. Viddeleer, Stephan J. L. Bakker, Ija M. Nolte, Marco van Londen, Robert A. Pol
Frontiers in Nephrology.2024;[Epub] CrossRef
Eccentric Resistance Exercise Effects on Older Adults With Metabolic Syndrome
Wafina Rohadhia, Christine Kudiarasu, Tomoko Koeda, Yoshihiro Katsura, Kazunori Nosaka, Favil Singh
Journal of Clinical Exercise Physiology.2024; 13(4): 129. CrossRef
Prevalence of adiposity-based chronic disease and its association with anthropometric and clinical indices: a cross-sectional study
Luis E González-Salazar, Aurora E Serralde-Zúñiga, Adriana Flores-López, Juan P Díaz-Sánchez, Isabel Medina-Vera, Edgar Pichardo-Ontiveros, Rocío Guizar-Heredia, Karla G Hernández-Gómez, Ana Vigil-Martínez, Liliana Arteaga-Sánchez, Azalia Avila-Nava, Nata
British Journal of Nutrition.2023; 130(1): 93. CrossRef
Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions
Ilse Vanhorebeek, Jan Gunst, Michaël P Casaer, Inge Derese, Sarah Derde, Lies Pauwels, Johan Segers, Greet Hermans, Rik Gosselink, Greet Van den Berghe
Journal of the Endocrine Society.2023;[Epub] CrossRef
Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
Norsham Juliana, Liyana Azmi, Nadia Mohd Effendy, Nur Islami Mohd Fahmi Teng, Izuddin Fahmy Abu, Nur Nabilah Abu Bakar, Sahar Azmani, Noor Anisah Abu Yazit, Suhaini Kadiman, Srijit Das
Nutrients.2023; 15(3): 734. CrossRef
Molecular mechanisms of post‐burn muscle wasting and the therapeutic potential of physical exercise
Dorien Dombrecht, Ulrike Van Daele, Birgit Van Asbroeck, David Schieffelers, Pieter‐Jan Guns, Nick Gebruers, Jill Meirte, Eric van Breda
Journal of Cachexia, Sarcopenia and Muscle.2023; 14(2): 758. CrossRef
Metabolic Impact of Frailty Changes Diabetes Trajectory
Alan J. Sinclair, Ahmed H. Abdelhafiz
Metabolites.2023; 13(2): 295. CrossRef
From Single- to Multi-organ-on-a-Chip System for Studying Metabolic Diseases
Minjeong Jang, Hong Nam Kim
BioChip Journal.2023; 17(2): 133. CrossRef
INFLUENCE OF SARCOPENIA ON THE COURSE AND PROGNOSIS IN PATIENTS WITH CHRONIC HEART FAILURE
Gulyaev N.I., Adamov A.A., Akhmetshin I.M.
"Medical & pharmaceutical journal "Pulse".2023; : 124. CrossRef
Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures
María Elena Soto, Israel Pérez-Torres, María Esther Rubio-Ruiz, Agustina Cano-Martínez, Linaloe Manzano-Pech, Verónica Guarner-Lans
International Journal of Molecular Sciences.2023; 24(5): 4534. CrossRef
Sarcoplasmic Reticulum Ca2+ Buffer Proteins: A Focus on the Yet-To-Be-Explored Role of Sarcalumenin in Skeletal Muscle Health and Disease
Elena Conte, Giorgia Dinoi, Paola Imbrici, Annamaria De Luca, Antonella Liantonio
Cells.2023; 12(5): 715. CrossRef
Antarctic krill extracts enhance muscle regeneration and muscle function via mammalian target of rapamycin regulation
Seongmin Lee, Mi-Ock Baek, Sana Abdul Khaliq, Amna Parveen, Sun Yeou Kim, Jin-Hyoung Kim, Il-Chan Kim, Mee-Sup Yoon
Journal of Functional Foods.2023; 103: 105483. CrossRef
Pharmacological and physiological roles of adipokines and myokines in metabolic-related dementia
Archana Arjunan, Juhyun Song
Biomedicine & Pharmacotherapy.2023; 163: 114847. CrossRef
PRMT5 links lipid metabolism to contractile function of skeletal muscles
Kun Ho Kim, Zhihao Jia, Madigan Snyder, Jingjuan Chen, Jiamin Qiu, Stephanie N Oprescu, Xiyue Chen, Sabriya A Syed, Feng Yue, Bruno T Roseguini, Anthony N Imbalzano, Changdeng Hu, Shihuan Kuang
EMBO reports.2023;[Epub] CrossRef
“Biqi” Bayberry Extract Promotes Skeletal Muscle Fiber Type Remodeling by Increasing Fast Myofiber Formation via the Akt/FoxO1 Pathway in Mice
Jinjie Li, Yi Li, Xiangying Suo, Jiangtao Li, Da Huang, Guangning Kou
Foods.2023; 12(13): 2471. CrossRef
Effects of high-intensity interval training (HIIT) on skeletal muscle atrophy, function, and myokine profile in diabetic myopathy
Yeşim Özçatal, Fırat Akat, Yakup Tatar, Hakan Fıçıcılar, Bilge Serdaroğlu, Ferda Topal Çelikkan, Metin Baştuğ
Cytokine.2023; 169: 156279. CrossRef
Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy
Jordan D. Fuqua, Marcus M. Lawrence, Zachary R. Hettinger, Agnieszka K. Borowik, Parker L. Brecheen, Marcelina M. Szczygiel, Claire B. Abbott, Frederick F. Peelor, Amy L. Confides, Michael Kinter, Sue C. Bodine, Esther E. Dupont‐Versteegden, Benjamin F. M
Journal of Cachexia, Sarcopenia and Muscle.2023; 14(5): 2076. CrossRef
Body physique rating as a factor to identify at-risk Mexicans for Metabolic Syndrome
Oscar Herrera-Fomperosa, Sergio K. Bustamante-Villagomez, Sarahí Vazquez-Álvarez, Gabriela Vázquez-Marroquín, Leonardo M. Porchia, Enrique Torres-Rasgado, Ricardo Pérez-Fuentes, M. Elba Gonzalez-Mejia
Human Nutrition & Metabolism.2023; 33: 200206. CrossRef
Association between Fractional Oxygen Extraction from Resting Quadriceps Muscle and Body Composition in Healthy Men
Rodrigo Yáñez-Sepúlveda, Jorge Olivares-Arancibia, Guillermo Cortés-Roco, Aldo Vasquez-Bonilla, Matías Monsalves-Álvarez, Ildefonso Alvear-Órdenes, Marcelo Tuesta
Journal of Functional Morphology and Kinesiology.2023; 8(4): 149. CrossRef
Correlations between Mental Health, Physical Activity, and Body Composition in American College Students after the COVID-19 Pandemic Lockdown
Luis Torres, Manuela C. Caciula, Alin S. Tomoiaga, Carmen Gugu-Gramatopol
International Journal of Environmental Research and Public Health.2023; 20(22): 7045. CrossRef
Association between total body muscle percentage and prevalence of non-alcoholic fatty liver disease in Korean adults findings from an 18-year follow-up: a prospective cohort study
Byoung Chan Ahn, Chul Yong Park, Jung Hee Hong, Ki Ook Baek
Journal of Yeungnam Medical Science.2023; 40(Suppl): S47. CrossRef
The independent and joint associations among muscle strength, abdominal obesity and cardiometabolic variables among adults
Tiago Rodrigues de Lima, David Alejandro González‐Chica, Xuemei Sui, Diego Augusto Santos Silva
European Journal of Sport Science.2022; 22(7): 1122. CrossRef
Mentale Gesundheit und physische Aktivität
Wolfgang Laube
Manuelle Medizin.2022; 60(1): 13. CrossRef
A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song
Biomedicine & Pharmacotherapy.2022; 147: 112636. CrossRef
Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle
James W. Daily, Sunmin Park
Cells.2022; 11(3): 338. CrossRef
Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits
Eun Kyung Choe, Manu Shivakumar, Anurag Verma, Shefali Setia Verma, Seung Ho Choi, Joo Sung Kim, Dokyoon Kim
Scientific Reports.2022;[Epub] CrossRef
Zika virus disrupts gene expression in human myoblasts and myotubes: Relationship with susceptibility to infection
Ingo Riederer, Daniella Arêas Mendes-da-Cruz, Guilherme Cordenonsi da Fonseca, Mariela Natacha González, Otavio Brustolini, Cássia Rocha, Guilherme Loss, Joseane Biso de Carvalho, Mariane Talon Menezes, Lidiane Menezes Souza Raphael, Alexandra Gerber, Myr
PLOS Neglected Tropical Diseases.2022; 16(2): e0010166. CrossRef
Teil 1: Muskeldysfunktionen – mit Training gegen Schmerz
Wolfgang Laube
Manuelle Medizin.2022; 60(2): 84. CrossRef
Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle
Liyan Fan, David R. Sweet, Erica K. Fan, Domenick A. Prosdocimo, Annmarie Madera, Zhen Jiang, Roshan Padmanabhan, Saptarsi M. Haldar, Vinesh Vinayachandran, Mukesh K. Jain
Journal of Biological Chemistry.2022; 298(6): 101926. CrossRef
An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches
Mizael C. Araújo, Suzany H. S. Soczek, Jaqueline P. Pontes, Leonardo A. C. Marques, Gabriela S. Santos, Gisele Simão, Laryssa R. Bueno, Daniele Maria-Ferreira, Marcelo N. Muscará, Elizabeth S. Fernandes
Cells.2022; 11(8): 1292. CrossRef
Effects of a 10-Week Physical Activity Intervention on Asylum Seekers’ Physiological Health
Matheus Guerra, Danilo Garcia, Maryam Kazemitabar, Erik Lindskär, Erica Schütz, Daniel Berglind
Brain Sciences.2022; 12(7): 822. CrossRef
Low muscle mass and mortality risk later in life: A 10-year follow-up study
Cristina Camargo Pereira, Valéria Pagotto, Cesar de Oliveira, Erika Aparecida Silveira, Kiyoshi Sanada
PLOS ONE.2022; 17(7): e0271579. CrossRef
Independent and joint associations of weightlifting and aerobic activity with all-cause, cardiovascular disease and cancer mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Jessica Gorzelitz, Britton Trabert, Hormuzd A Katki, Steven C Moore, Eleanor L Watts, Charles E Matthews
British Journal of Sports Medicine.2022; 56(22): 1277. CrossRef
Handgrip Strength Cutoff Value Among Korean Adolescents with Metabolic Syndrome Components: Korean National Health and Nutrition Examination Survey Data 2014–2017
Chang Hoon Lee, Jun Hyeok Lee, Yong Whi Jeong, Hong Koh, Yunkoo Kang
Metabolic Syndrome and Related Disorders.2022; 20(10): 584. CrossRef
Physical activity level, sitting time, and skeletal muscle mass between esports players and non-esports players
Zhi H. SEE, Mohamad S. ABDUL HAMID
Gazzetta Medica Italiana Archivio per le Scienze Mediche.2022;[Epub] CrossRef
Impact of the Nutrition–Inflammation Status on the Functionality of Patients with Chronic Kidney Disease
Ángel Nogueira, Graciela Álvarez, Guillermina Barril
Nutrients.2022; 14(22): 4745. CrossRef
Does Timing Matter? A Narrative Review of Intermittent Fasting Variants and Their Effects on Bodyweight and Body Composition
Alan A. Aragon, Brad J. Schoenfeld
Nutrients.2022; 14(23): 5022. CrossRef
Sex- and region-specific associations of skeletal muscle mass with metabolic dysfunction-associated fatty liver disease
Pei Xiao, Pu Liang, Panjun Gao, Jinyi Wu
Frontiers in Endocrinology.2022;[Epub] CrossRef
Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
Takahiro Tomiyama, Noboru Harada, Takeo Toshima, Yuki Nakayama, Katsuya Toshida, Akinari Morinaga, Yukiko Kosai-Fujimoto, Takahiro Tomino, Takeshi Kurihara, Kazuki Takeishi, Yoshihiro Nagao, Kazutoyo Morita, Shinji Itoh, Tomoharu Yoshizumi
Transplant International.2022;[Epub] CrossRef
Handgrip Strength Is Associated with Metabolic Syndrome and Insulin Resistance in Children and Adolescents: Analysis of Korea National Health and Nutrition Examination Survey 2014–2018
Hae Woon Jung, Jieun Lee, Jaehyun Kim
Journal of Obesity & Metabolic Syndrome.2022; 31(4): 334. CrossRef
Diet quality and a traditional dietary pattern predict lean mass in Australian women: Longitudinal data from the Geelong Osteoporosis Study
Jessica A. Davis, Mohammadreza Mohebbi, Fiona Collier, Amy Loughman, Nitin Shivappa, James R. Hébert, Julie A. Pasco, Felice N. Jacka
Preventive Medicine Reports.2021; 21: 101316. CrossRef
Association between serum FGF21 level and sarcopenia in older adults
Hee-Won Jung, Jin Hoon Park, Da Ae Kim, Il-Young Jang, So Jeong Park, Jin Young Lee, Seungjoo Lee, Jeoung Hee Kim, Hyon-Seung Yi, Eunju Lee, Beom-Jun Kim
Bone.2021; 145: 115877. CrossRef
Benchside to the bedside of frailty and cardiovascular aging: Main shared cellular and molecular mechanisms
Sandra Maria Barbalho, Ricardo José Tofano, Eduardo Federigui Baisi Chagas, Cláudia Rucco Penteado Detregiachi, Ricardo de Alvares Goulart, Uri Arian Princ Flato
Experimental Gerontology.2021; 148: 111302. CrossRef
Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
Da Ae Kim, So Jeong Park, Jin Young Lee, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Beom-Jun Kim
Endocrinology and Metabolism.2021; 36(2): 455. CrossRef
Sarcopenic obesity as a determinant of cardiovascular disease risk in older people: a systematic review
Katherine Evans, Dima Abdelhafiz, Ahmed H Abdelhafiz
Postgraduate Medicine.2021; 133(8): 831. CrossRef
Decreased continuous sitting time increases heart rate variability in patients with cardiovascular risk factors
Natsuki Nakayama, Masahiko Miyachi, Koji Tamakoshi, Toshio Hayashi, Koji Negi, Koji Watanabe, Makoto Hirai, Sharon Mary Brownie
PLOS ONE.2021; 16(6): e0253399. CrossRef
Muskeltraining – ein universelles Medikament
Wolfgang Laube
Manuelle Medizin.2021; 59(3): 179. CrossRef
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Liya Kerem, Elizabeth A. Lawson
International Journal of Molecular Sciences.2021; 22(14): 7737. CrossRef
Weight Loss Strategies and the Risk of Skeletal Muscle Mass Loss
David McCarthy, Aloys Berg
Nutrients.2021; 13(7): 2473. CrossRef
Association of FGF‐19 and FGF‐21 levels with primary sarcopenia
Rabia Bag Soytas, Veysel Suzan, Pinar Arman, Tugce Emiroglu Gedik, Damla Unal, Mahir Cengiz, Ibrahim Murat Bolayirli, Deniz Suna Erdincler, Alper Doventas, Hakan Yavuzer
Geriatrics & Gerontology International.2021; 21(10): 959. CrossRef
Der Muskulatur mehr Aufmerksamkeit schenken!
Wolfgang Laube
Manuelle Medizin.2021; 59(4): 302. CrossRef
Methodology, clinical applications, and future directions of body composition analysis using computed tomography (CT) images: A review
Antti Tolonen, Tomppa Pakarinen, Antti Sassi, Jere Kyttä, William Cancino, Irina Rinta-Kiikka, Said Pertuz, Otso Arponen
European Journal of Radiology.2021; 145: 109943. CrossRef
Waist and hip circumference are independently associated with the risk of liver disease in population‐based studies
Oscar Danielsson, Markku J. Nissinen, Antti Jula, Veikko Salomaa, Satu Männistö, Annamari Lundqvist, Markus Perola, Fredrik Åberg
Liver International.2021; 41(12): 2903. CrossRef
Understanding of sarcopenia: from definition to therapeutic strategies
Jee Won Kim, Ryuni Kim, Hyerim Choi, Sang-Jin Lee, Gyu-Un Bae
Archives of Pharmacal Research.2021; 44(9-10): 876. CrossRef
Muscle strength and its association with cardiometabolic variables in adolescents: does the expression of muscle strength values matter?
Tiago Rodrigues de Lima, Xuemei Sui, Luiz Rodrigo Augustemak de Lima, Diego Augusto Santos Silva
World Journal of Pediatrics.2021; 17(6): 597. CrossRef
Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults
Yeliana L. Sánchez, Manuela Yepes-Calderón, Luis Valbuena, Andrés F. Milán, María C. Trillos-Almanza, Sergio Granados, Miguel Peña, Mauricio Estrada-Castrillón, Juan C. Aristizábal, Raúl Narvez-Sanchez, Jaime Gallo-Villegas, Juan C. Calderón
Endocrinology and Metabolism.2021; 36(5): 1055. CrossRef
Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications
Sandra Maria Barbalho, Uri Adrian Prync Flato, Ricardo José Tofano, Ricardo de Alvares Goulart, Elen Landgraf Guiguer, Cláudia Rucco P. Detregiachi, Daniela Vieira Buchaim, Adriano Cressoni Araújo, Rogério Leone Buchaim, Fábio Tadeu Rodrigues Reina, Piero
International Journal of Molecular Sciences.2020; 21(10): 3607. CrossRef
Prevalence of Metabolic Syndrome and Association with Grip Strength in Older Adults: Findings from the HOPE Study

Reshma Aziz Merchant, Yiong Huak Chan, Jia Yi Lim, John E Morley
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 2677. CrossRef
Lower Serum n-3 Fatty Acid Level in Older Adults with Sarcopenia
Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Jin Young Lee, So Jeong Park, Da Ae Kim, Su Jung Kim, Hyun Ju Yoo, Beom-Jun Kim
Nutrients.2020; 12(10): 2959. CrossRef
Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics
Minmin Yang, Tao Yan, Meng Yu, Jie Kang, Ruoxi Gao, Peng Wang, Yuhuan Zhang, Huafeng Zhang, Lin Shi
Food Frontiers.2020; 1(4): 398. CrossRef
The association of circulating kynurenine, a tryptophan metabolite, with frailty in older adults
Il-Young Jang, Jin Hoon Park, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Jin Young Lee, So Jeong Park, Da Ae Kim, Mark W. Hamrick, Beom-Jun Kim
Aging.2020; 12(21): 22253. CrossRef
Sarcopenia and Muscle Aging: A Brief Overview
Tam Dao, Alexander E. Green, Yun A Kim, Sung-Jin Bae, Ki-Tae Ha, Karim Gariani, Mi-ra Lee, Keir J. Menzies, Dongryeol Ryu
Endocrinology and Metabolism.2020; 35(4): 716. CrossRef

Original Article

Clinical Study
Triiodothyronine Levels Are Independently Associated with Metabolic Syndrome in Euthyroid Middle-Aged Subjects: Hye Jeong Kim, Ji Cheol Bae, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo, Jae Hyeon Kim, Yong-Ki Min, Sun Wook Kim, Jae Hoon Chung; Endocrinol Metab. 2016;31(2):311-319. Published online May 13, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.2.311

6,085 View
35 Download
27 Web of Science
25 Crossref

Abstract PDF Supplementary Material PubReader

Background

Recent studies have shown an association between thyroid hormone levels and metabolic syndrome (MetS) among euthyroid individuals; however, there have been some inconsistencies between studies. Here, we evaluated the relationship between thyroid hormone levels and MetS in euthyroid middle-aged subjects in a large cohort.

Methods

A retrospective analysis of 13,496 euthyroid middle-aged subjects who participated in comprehensive health examinations was performed. Subjects were grouped according to thyroid stimulating hormone, total triiodothyronine (T3), total thyroxine (T4), and T3-to-T4 ratio quartile categories. We estimated the odds ratios (ORs) for MetS according to thyroid hormone quartiles using logistic regression models, adjusted for potential confounders.

Results

Of the study patients, 12% (n=1,664) had MetS. A higher T3 level and T3-to-T4 ratio were associated with unfavourable metabolic profiles, such as higher body mass index, systolic and diastolic blood pressure, triglycerides, fasting glucose and glycated hemoglobin, and lower high density lipoprotein cholesterol levels. The proportion of participants with MetS increased across the T3 quartile categories (P for trend <0.001) and the T3-to-T4 ratio quartile categories (P for trend <0.001). The multi-variate-adjusted OR (95% confidence interval) for MetS in the highest T3 quartile group was 1.249 (1.020 to 1.529) compared to the lowest T3 quartile group, and that in the highest T3-to-T4 ratio quartile group was 1.458 (1.141 to 1.863) compared to the lowest T3-to-T4 ratio quartile group, even after adjustment for potential confounders.

Conclusion

Serum T3 levels and T3-to-T4 ratio are independently associated with MetS in euthyroid middle-aged subjects. Longitudinal studies are needed to define this association and its potential health implications.

Citations

Citations to this article as recorded by

Thyroid Hormones and Diabetes in Euthyroid Hispanic/Latino Adults of Diverse Backgrounds: HCHS/SOL
Victoria Persky, Chibuzor Abasilim, Konstantina Tsintsifas, Tessa Day, Robert M Sargis, Martha Daviglus, Jianwen Cai, Sally Freels, Robert Kaplan, Carmen R Isasi, Amber Pirzada, Michelle L Meyer, Gregory A Talavera, Bharat Thyagarajan, Shivani Agarwal, No
Journal of the Endocrine Society.2024;[Epub] CrossRef
Myxedema in Both Hyperthyroidism and Hypothyroidism: A Hormetic Response?
Salvatore Sciacchitano, Angela Napoli, Monica Rocco, Claudia De Vitis, Rita Mancini
International Journal of Molecular Sciences.2024; 25(18): 9957. CrossRef
The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin αvβ3)-mediated cell adhesion of human umbilical vein endothelial cells
Maša Kenda, Urša Pečar Fonović, Janko Kos, Marija Sollner Dolenc
Toxicology in Vitro.2022; 79: 105275. CrossRef
Could the ketogenic diet induce a shift in thyroid function and support a metabolic advantage in healthy participants? A pilot randomized-controlled-crossover trial
Stella Iacovides, Shane K. Maloney, Sindeep Bhana, Zareena Angamia, Rebecca M. Meiring, Carla Pegoraro
PLOS ONE.2022; 17(6): e0269440. CrossRef
Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults
Han-Bin Huang, Po-Keng Cheng, Chi-Ying Siao, Yuan-Ting C. Lo, Wei-Chun Chou, Po-Chin Huang
Environmental Health.2022;[Epub] CrossRef
Cholinesterase homozygous genotype as susceptible biomarker of hypertriglyceridaemia for pesticide-exposed agricultural workers
Xingfan Zhou, Min Zhang, Yuqian Wang, Hailing Xia, Lijin Zhu, Guangyi Li, Li Rong, Huahuang Dong, Rui Chen, Shichuan Tang, Min Yu
Biomarkers.2021; 26(4): 335. CrossRef
Association between thyroid hormone and components of metabolic syndrome in euthyroid Korean adults
Kyung A. Shin, Eun Jae Kim
Medicine.2021; 100(51): e28409. CrossRef
Clinical Parameters Are More Likely to Be Associated with Thyroid Hormone Levels than with Thyrotropin Levels: A Systematic Review and Meta-Analysis
Stephen P. Fitzgerald, Nigel G. Bean, Henrik Falhammar, Jono Tuke
Thyroid.2020; 30(12): 1695. CrossRef
The role of thyroid hormone in metabolism and metabolic syndrome
Patrícia de Fátima dos Santos Teixeira, Patrícia Borges dos Santos, Carmen Cabanelas Pazos-Moura
Therapeutic Advances in Endocrinology and Metabolism.2020;[Epub] CrossRef
Association between Abdominal Fat Distribution and Free Triiodothyronine in a Euthyroid Population
Xiaomin Nie, Yiting Xu, Xiaojing Ma, Yunfeng Xiao, Yufei Wang, Yuqian Bao
Obesity Facts.2020; 13(3): 358. CrossRef
Association of thyroid function with white coat hypertension and sustained hypertension
Peng Cai, Yan Peng, YuXi Chen, Li Li, Wei Chu, Yan Wang, Xukai Wang
The Journal of Clinical Hypertension.2019; 21(5): 674. CrossRef
Thyroid function is associated with body mass index and fasting plasma glucose in Thai euthyroid population
Amornpan Lertrit, La-or Chailurkit, Boonsong Ongphiphadhanakul, Wichai Aekplakorn, Chutintorn Sriphrapradang
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 468. CrossRef
Thyroid disease and the metabolic syndrome
Ladan Mehran, Atieh Amouzegar, Fereidoun Azizi
Current Opinion in Endocrinology, Diabetes & Obesity.2019; 26(5): 256. CrossRef
Morbid obez hastalarda kilo kaybının insulin direnci, bazal metabolizma hızı, antropometrik ölçümler ve tiroid fonksiyonlarına etkisi
Şenay DURMAZ CEYLAN, Şuuri Ahsen CEYLAN, Fatih EKER, Aşkın GÜNGÜNEŞ
Anadolu Güncel Tıp Dergisi.2019; 1(4): 99. CrossRef
Body Composition, Resting Energy Expenditure, and Metabolic Changes in Women Diagnosed with Differentiated Thyroid Carcinoma
Elena Izkhakov, Nachum Vaisman, Sophie Barnes, Micha Barchana, Naftali Stern, Lital Keinan-Boker
Thyroid.2019; 29(8): 1044. CrossRef
High TSH Level within Normal Range Is Associated with Obesity, Dyslipidemia, Hypertension, Inflammation, Hypercoagulability, and the Metabolic Syndrome: A Novel Cardiometabolic Marker
Yi-Cheng Chang, Shih-Che Hua, Chia-Hsuin Chang, Wei-Yi Kao, Hsiao-Lin Lee, Lee-Ming Chuang, Yen-Tsung Huang, Mei-Shu Lai
Journal of Clinical Medicine.2019; 8(6): 817. CrossRef
Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study
Luís Raposo, Sandra Martins, Daniela Ferreira, João Tiago Guimarães, Ana Cristina Santos
Endocrine, Metabolic & Immune Disorders - Drug Targets.2019; 19(1): 75. CrossRef
Hormesis in Health and Chronic Diseases
Xin Li, Tingting Yang, Zheng Sun
Trends in Endocrinology & Metabolism.2019; 30(12): 944. CrossRef
Relationship of metabolic syndrome and its components with thyroid dysfunction in Algerian patients
Mohamed Larbi Hamlaoui, Ammar Ayachi, Aoulia Dekaken, Adel Gouri
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2018; 12(1): 1. CrossRef
High free triiodothyronine and free-triiodothyronine-to-free-thyroxine ratio levels are associated with metabolic syndrome in a euthyroid population
Diego Urrunaga-Pastor, Mirella Guarnizo-Poma, Enrique Moncada-Mapelli, Luis G. Aguirre, Herbert Lazaro-Alcantara, Socorro Paico-Palacios, Betzi Pantoja-Torres, Vicente A. Benites-Zapata
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2018; 12(2): 155. CrossRef
Exploring the association between thyroid- stimulating hormone and metabolic syndrome: A large population-based study
Yi-Chao Zhou, Wen-Hui Fang, Tung-Wei Kao, Chung-Ching Wang, Yaw-Wen Chang, Tao-Chun Peng, Chen-Jung Wu, Hui-Fang Yang, James Yi-Hsin Chan, Wei-Liang Chen, Tatsuo Shimosawa
PLOS ONE.2018; 13(6): e0199209. CrossRef
Thyroid function and metabolic syndrome in the population-based LifeLines cohort study
Bruce H. R. Wolffenbuttel, Hanneke J. C. M. Wouters, Sandra N. Slagter, Robert P. van Waateringe, Anneke C. Muller Kobold, Jana V. van Vliet-Ostaptchouk, Thera P. Links, Melanie M. van der Klauw
BMC Endocrine Disorders.2017;[Epub] CrossRef
Hormetic effect of triiodothyronine in metabolically healthy obese persons
Ji Eun Jun, Tae Hyuk Kim, Seung-Eun Lee, You-Bin Lee, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Yong-Ki Min, Moon-Kyu Lee
Endocrine.2017; 57(3): 418. CrossRef
Association of triiodothyronine levels with future development of metabolic syndrome in euthyroid middle-aged subjects: a 6-year retrospective longitudinal study
Hye Jeong Kim, Ji Cheol Bae, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo, Jee Jae Hwan, Jae Hyeon Kim, Yong-Ki Min, Sun Wook Kim, Jae Hoon Chung
European Journal of Endocrinology.2017; 176(4): 443. CrossRef
Articles inEndocrinology and Metabolismin 2016
Won-Young Lee
Endocrinology and Metabolism.2017; 32(1): 62. CrossRef

Case Report

Adrenal gland
Bilateral Adrenocortical Masses Producing Aldosterone and Cortisol Independently: Seung-Eun Lee, Jae Hyeon Kim, You-Bin Lee, Hyeri Seok, In Seub Shin, Yeong Hee Eun, Jung-Han Kim, Young Lyun Oh; Endocrinol Metab. 2015;30(4):607-613. Published online December 31, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.4.607

5,786 View
54 Download
6 Web of Science
6 Crossref

Abstract PDF PubReader

A 31-year-old woman was referred to our hospital with symptoms of hypertension and bilateral adrenocortical masses with no feature of Cushing syndrome. The serum aldosterone/renin ratio was elevated and the saline loading test showed no suppression of the plasma aldosterone level, consistent with a diagnosis of primary hyperaldosteronism. Overnight and low-dose dexamethasone suppression tests showed no suppression of serum cortisol, indicating a secondary diagnosis of subclinical Cushing syndrome. Adrenal vein sampling during the low-dose dexamethasone suppression test demonstrated excess secretion of cortisol from the left adrenal mass. A partial right adrenalectomy was performed, resulting in normalization of blood pressure, hypokalemia, and high aldosterone level, implying that the right adrenal mass was the main cause of the hyperaldosteronism. A total adrenalectomy for the left adrenal mass was later performed, resulting in a normalization of cortisol level. The final diagnosis was bilateral adrenocortical adenomas, which were secreting aldosterone and cortisol independently. This case is the first report of a concurrent cortisol-producing left adrenal adenoma and an aldosterone-producing right adrenal adenoma in Korea, as demonstrated by adrenal vein sampling and sequential removal of adrenal masses.

Citations

Citations to this article as recorded by

Bilateral adrenal adenomas with autonomous cortisol secretion from both glands and autonomous aldosterone secretion from the left adrenal: a case report
Jung Eun Han, Soyeon Yoo, Sang Ah Lee, Gwanpyo Koh
Journal of Yeungnam Medical Science.2025; 42: 33. CrossRef
Problems of diagnosis and treatment of Connshing syndrome
M. S. Annaev, B. I. Geltser, K. V. Stegniy, O. I. Pak, R. A. Goncharuk, S. M. Selyutin, A. M. Morozova, O. G. Tsygankova, E. V. Maslyantsev, V. G. Fisenko
Clinical Medicine (Russian Journal).2024; 102(4): 367. CrossRef
Different cell compositions and a novel somatic KCNJ5 variant found in a patient with bilateral adrenocortical adenomas secreting aldosterone and cortisol
Liling Zhao, Jinjing Wan, Yujun Wang, Wenjun Yang, Qi Liang, Jinrong Wang, Ping Jin
Frontiers in Endocrinology.2023;[Epub] CrossRef
Adrenal Vein Cortisol to Metanephrine Ratio for Localizing ACTH-Independent Cortisol-Producing Adenoma: A Case Report
Rishi Raj, Philip A Kern, Neelima Ghanta, Edilfavia M Uy, Kamyar Asadipooya
Journal of the Endocrine Society.2021;[Epub] CrossRef
Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism
Mitsuhide Naruse, Akiyo Tanabe, Koichi Yamamoto, Hiromi Rakugi, Mitsuhiro Kometani, Takashi Yoneda, Hiroki Kobayashi, Masanori Abe, Youichi Ohno, Nobuya Inagaki, Shoichiro Izawa, Masakatsu Sone
Endocrinology and Metabolism.2021; 36(5): 965. CrossRef
Hypercortisolism and primary aldosteronism caused by bilateral adrenocortical adenomas: a case report
Kaiyun Ren, Jia Wei, Qilin Liu, Yuchun Zhu, Nianwei Wu, Ying Tang, Qianrui Li, Qianying Zhang, Yerong Yu, Zhenmei An, Jing Chen, Jianwei Li
BMC Endocrine Disorders.2019;[Epub] CrossRef

First
Prev
Page of 2
Next
Last

Search