KES
Search
- Page Path
- HOME > Search
Brief Report
- Diabetes, obesity and metabolism
- Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice
- Jooyeop Lee, Min Joo Kim, Seoil Moon, Ji Yoon Lim, Kyong Soo Park, Hye Seung Jung
- Endocrinol Metab. 2023;38(6):782-787. Published online November 13, 2023
- DOI: https://doi.org/10.3803/EnM.2023.1738
- 5,431 View
- 84 Download
- 2 Web of Science
- 3 Crossref
-
Abstract
PDF
Supplementary Material
PubReader 
ePub - Although pancreatic endoplasmic reticulum kinase (PERK) is indispensable to beta cells, low-dose PERK inhibitor improved glucose- stimulated insulin secretion (GSIS) and hyperglycemia in diabetic mice. Current study examined if partial deletion of Perk (Perk+/-) recapitulated the effects of PERK inhibitor, on the contrary to the complete deletion. Perk+/- mice and wild-type controls were fed with a high-fat diet (HFD) for 23 weeks. Glucose tolerance was evaluated along with serum insulin levels and islet morphology. Perk+/- mice on normal chow were comparable to wild-type mice in various metabolic features. HFD-induced obesity was not influenced by Perk reduction; however, HFD-induced glucose intolerance was significantly improved since 15-week HFD. HFD-induced compromises in GSIS were relieved by Perk reduction, accompanied by reductions in phosphorylated PERK and activating transcription factor 4 (ATF4) in the islets. Meanwhile, HFD-induced islet expansion was not significantly affected. In summary, partial deletion of Perk improved glucose tolerance and GSIS impaired by diet-induced obesity, without changes in body weights or islet mass.
-
Citations
Citations to this article as recorded by
- Proteomic Analysis on Human Islets Suggests Nucleocytoplasmic Transport as a Mechanism of PERK Attenuation Effects in Diabetes
Yeon Soo Park, Soeun Yun, Min Seop Sim, Eun Jin An, Jin Lee, Eun Hee Ha, Jin-Young Jang, Wooil Kwon, Dohyun Han, Hye Seung Jung
Molecular & Cellular Proteomics.2026; 25(6): 101588. CrossRef - The UPR-oxidative stress nexus in diabetes and obesity: Exploring innovative therapeutic approaches for metabolic control
Clinton Ayodeji Akanbi, Oluwafemi Adeleke Ojo
Obesity Medicine.2025; 57: 100634. CrossRef - Oral Indole-3-acetate Supplementation Increases the Abundance of Bifidobacterium pseudolongum and Akkermansia muciniphila in the Intestine of Mice on a High-Fat Diet
O. P. Shatova, A. A. Zabolotneva, S. A. Rumyantsev, A. V. Shestopalov
Russian Journal of Bioorganic Chemistry.2025; 51(5): 2041. CrossRef
- Proteomic Analysis on Human Islets Suggests Nucleocytoplasmic Transport as a Mechanism of PERK Attenuation Effects in Diabetes
First
Prev
