Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "Ablation techniques"
Filter
Filter
Article type
Keywords
Publication year
Authors
Funded articles
Review Article
Thyroid
Novel and Advanced Ultrasound Techniques for Thyroid Thermal Ablation
Wai-Kin Chan, Jui-Hung Sun, Miaw-Jene Liou, Chia-Jung Hsu, Yu-Ling Lu, Wei-Yu Chou, Yan-Rong Li, Feng-Hsuan Liu
Endocrinol Metab. 2024;39(1):40-46.   Published online February 13, 2024
DOI: https://doi.org/10.3803/EnM.2024.1917
  • 11,880 View
  • 421 Download
  • 12 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   ePub   
Thyroid radiofrequency ablation and microwave ablation are widely adopted minimally invasive treatments for diverse thyroid conditions worldwide. Fundamental skills such as the trans-isthmic approach and the moving shot technique are crucial for performing thyroid ablation, and advanced techniques, including hydrodissection and vascular ablation, improve safety and efficacy and reduce complications. Given the learning curve associated with ultrasound-guided therapeutic procedures, operators need training and experience. While training models exist, limited attention has been given to ultrasound maneuvers in ablation needle manipulation. This article introduces two essential maneuvers, the zigzag moving technique and the alienate maneuver, while also reviewing the latest ultrasound techniques in thyroid ablation, contributing valuable insights into this evolving field.

Citations

Citations to this article as recorded by  
  • A cost-effective porcine training model for thermal ablation of thyroid nodules and subsequent transoral endoscopic thyroidectomy
    Lei Min, Yujing Weng, Weichun Chen, Debiao Chen, Qing Ai, Jiang Jiang, Zhiheng Huang
    Minimally Invasive Therapy & Allied Technologies.2026; 35(1): 79.     CrossRef
  • Factors associated with early complete resolution after radiofrequency ablation for low-risk papillary thyroid microcarcinoma: a dual-center retrospective study
    Yuxuan Qiu, Yina Zhang, Jingqi Zhu, Yun Gong, Lu Yin, Pin Fan, Lian Zhang, Lingyun Bao, Jianhua Fang, Jun Lou, Chenke Xu
    European Radiology.2026; 36(7): 5277.     CrossRef
  • Controlled minimally invasive surgical interventions for the treatment of patients with thyroid carcinoma
    David D. Dolidze, Zurab A. Bagatelia, Suren G. Laboyan, Arshak V. Vardanyan, Konstantin S. Titov, Ivan N. Lebedinsky, Georgi Genadi Melkonyan, Dmitriy V. Matveev, Nodar N. Gogitidze, Andrei Y. Lukin, Armen R. Oganyan, David G. Gogolashvili, Anastasia V. B
    Journal of Experimental and Clinical Surgery.2026; 19(1): 45.     CrossRef
  • Expression of serum inflammatory factors and vascular endothelial growth factor and volume reduction rate in thyroid nodules treated with ultrasound-guided radiofrequency ablation
    Hui Yang, Mei Liu, Yadong Zhou, Yali He, Huijuan Jin
    Journal of Medical Biochemistry.2026; (00): 87.     CrossRef
  • North American Society for Interventional Thyroidology Statement on Directed Ablative Therapy for the Management of Low Risk Papillary Thyroid Carcinoma
    Chelsey K. Baldwin, Kaitlyn M. Frazier, Jennifer H. Kuo, Julia E. Noel, Jonathon O. Russell, Victoria E. Banuchi
    Endocrine Practice.2026;[Epub]     CrossRef
  • Volumetric outcomes of ultrasound-guided microwave ablation for benign thyroid nodules: A single-centre retrospective cohort study
    İsmail Engin, Ali H. Emirkadı, Zafer Ü. Coşkun
    Ultrasound.2026;[Epub]     CrossRef
  • Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy
    Yunfeng Wu, Yuxi Liu, Han Wu, Mengying Tong, Linyao Du, Shuangsong Ren, Ying Che
    International Journal of Nanomedicine.2025; Volume 20: 1425.     CrossRef
  • Diagnostic accuracy of ultrasound in hyperthyroidism: A comprehensive review of recent studies
    Dawei Wang, Chao Xie, Xuena Zheng, Min Li
    Journal of Radiation Research and Applied Sciences.2025; 18(2): 101370.     CrossRef
  • Current evidence and strategies for preventing tumor recurrence following thermal ablation of papillary thyroid carcinoma
    Ru Li, Luyang Yang, Ming Xu, Baofeng Wu, Qinhao Liu, Qin An, Yuchen Sun, Yi Zhang, Yunfeng Liu
    Cancer Imaging.2025;[Epub]     CrossRef
  • Ablación de nódulos tiroideos: revisión de la literatura
    Alex Wash Franulic
    Revista Médica Clínica Las Condes.2025; 36(4): 267.     CrossRef
  • Thermal ablation for papillary thyroid microcarcinoma in the isthmus: a systematic review and meta-analysis
    Yuqi Hao, Kun Liao, Ling Zeng, Lili Feng
    Endocrine Connections.2025;[Epub]     CrossRef
  • Current role of interventional radiology in thyroid nodules
    Onur Taydas, Erbil Arik, Omer Faruk Sevinc, Ahmet Burak Kara, Mustafa Ozdemir, Hasret Cengiz, Zulfu Bayhan, Mehmet Halil Ozturk
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Recurrent laryngeal nerve monitoring by flexible laryngoscopy during thyroid radiofrequency ablation in the awake patient
    Marsida Teliti, Antonio Occhini, Rodolfo Fonte, Laura Croce, Benedetto Calì, Federica Antonella Ripepi, Andrea Carbone, Mario Rotondi, Spyridon Chytiris
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
Close layer
Original Article
Clinical Study
Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis
Cheng-Chun Yang, Yung Hsu, Jyun-Yan Liou
Endocrinol Metab. 2021;36(1):81-95.   Published online February 24, 2021
DOI: https://doi.org/10.3803/EnM.2020.833
  • 15,044 View
  • 312 Download
  • 30 Web of Science
  • 37 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Ultrasound-guided minimally invasive procedures are widely used to treat thyroid diseases. The objective of this study was to assess the efficacy and safety of ethanol ablation (EA) in comparison with other non-surgical options in the treatment of benign thyroid cystic nodules.
Methods
We conducted a systematic search of studies on EA for thyroid cystic nodules, mainly in the Ovid-MEDLINE and Embase, Web of Science, and Cochrane databases. The standardized mean difference (SMD) of the volume reduction ratio (VRR) after EA versus other non-surgical treatments comprised the primary outcome, whereas the odds ratio (OR) of therapeutic success rates between the two groups comprised the secondary outcome.
Results
The meta-analysis included 19 studies (four randomized controlled trials and 15 non-randomized studies) with 1,514 participants. The cumulative VRR of EA was 83.908% (95% confidence interval [CI], 79.358% to 88.457%). EA had a significantly higher pooled VRR (SMD, 0.381; 95% CI, 0.028 to 0.734; P=0.030), but not a significantly higher pooled therapeutic success rate (OR, 0.867; 95% CI, 0.132 to 5.689; P=0.880), than other forms of non-surgical management including radiofrequency ablation (RFA), polidocanol sclerotherapy, and simple aspiration with or without saline flush. However, the VRR and therapeutic success rate were not significantly different between EA and RFA. Major complications were recorded only in six patients (0.53%) with self-limiting dysphonia.
Conclusion
The role of EA as the first-line treatment for benign thyroid cysts and predominantly cystic nodules is supported by its high effectiveness and good safety profile compared to other currently available non-surgical options.

Citations

Citations to this article as recorded by  
  • Quality of Life After Ethanol Ablation of Thyroid Nodules: A 1-Year Follow-Up Study
    Lorenzo Scappaticcio, Nicole Di Martino, Rita Matrone, Pamela Ferrazzano, Michela Di Nuzzo, Alessandra Volatile, Giovanni Cozzolino, Carla Carbone, Miriam Longo, Maria Ida Maiorino, Giovanni Docimo, Pierpaolo Trimboli, Giuseppe Bellastella, Katherine Espo
    Endocrine Practice.2026; 32(2): 149.     CrossRef
  • Comparison of microwave ablation versus lauromacrogol injection ablation for 50–75% cystic thyroid nodules: a two-center retrospective study
    Jiayan Bao, Wenbo Ding, Zheng Zhang, Yanwei Chen, Shuangshuang Zhao, Yun Cai, Wenjun Li, Jiwen Qian, Feng Zhao, Baoding Chen
    Frontiers in Endocrinology.2026;[Epub]     CrossRef
  • Post-procedural Thyroid Cyst Infection Following Aspiration and Polidocanol Sclerotherapy: A Case Report
    Sigfrido Miracle López, Marco-Antonio Alvarez-Arrazola
    Cureus.2026;[Epub]     CrossRef
  • North American Society for Interventional Thyroidology Statement on Directed Ablative Therapy for the Management of Benign Non-functional Thyroid Nodules
    Vaninder Kaur Dhillon, John Woody Sistrunk, David T. Hughes, Toni Beninato, Sumedha Chablani, Ralph P. Tufano, Chelsey K. Baldwin
    Endocrine Practice.2026;[Epub]     CrossRef
  • Efficacy of thyroid cyst sclerotherapy with polidocanol
    Ziga Mercun, Laura Martinjak, Edvard Pirnat, Simona Gaberscek, Katja Zaletel, Katica Bajuk Studen
    Radiology and Oncology.2026; 60(2): 282.     CrossRef
  • Ethanol ablation of cystic thyroid nodules: institutional experience with one year follow-up
    Lorenzo Scappaticcio, Nicole Di Martino, Pamela Ferrazzano, Miriam Longo, Luca Marinelli, Giovanni Docimo, Maria Ida Maiorino, Giuseppe Bellastella, Salvatore Cappabianca, Katherine Esposito
    La radiologia medica.2026; 131(7): 1228.     CrossRef
  • Ablation of cystic thyroid nodules with or without the injection of ethanol prior to aspiration: a one-year follow-up study
    Lorenzo Scappaticcio, Nicole Di Martino, Pamela Ferrazzano, Silvia Angelino, Michela Di Nuzzo, Miriam Longo, Alessandro Monaco, Giovanni Docimo, Maria Ida Maiorino, Katherine Esposito, Giuseppe Bellastella
    Updates in Surgery.2026;[Epub]     CrossRef
  • EndoBridge 2025: pearls and highlights
    Bulent Okan Yildiz, Mirco Armenti, Maria Luisa Brandi, John Carey, Tobias Carling, Andreea Ciudin, Ketan Dhatariya, Athanasios Fountas, Gema Frühbeck, Dimitrios Goulis, Maria Grammatikopoulou, Mark Gurnell, Gary D. Hammer, Angelica Lindén Hirschberg, Susa
    Hormones.2026;[Epub]     CrossRef
  • Efficacy Comparison and Prognostic Factor Analysis of Ultrasound‐Guided Microwave Ablation Alone Versus Combined with Lauromacrogol Sclerotherapy for Mixed Cystic‐Solid Thyroid Nodules
    Jie Wang, Qingmin Fan, Xiaofeng Wu, Ting Lu, Junchen Yan, Xiaojing Wan, Fenglin Dong
    Journal of Ultrasound in Medicine.2026;[Epub]     CrossRef
  • Clinical outcomes of medical therapy, EUS-guided ethanol ablation, and surgical resection in insulinoma: a clinical epidemiology study
    Jin-Ying Lu, Fan Chou, Tsu-Yao Cheng, Fang-Yu Wen, Yu-Wen Tien, Ting-Chun Kuo, Chin-Chen Chang, Wan-Chen Wu, Wei-Yi Chiu, Shyang-Rong Shih, Pei-Lung Chen, Chih-Yuan Wang, Hsiu-Po Wang, Fu-Chang Hu
    Frontiers in Endocrinology.2026;[Epub]     CrossRef
  • Percutaneous ethanol injection for thyroid nodules
    David Lee, Alex Tessnow
    Operative Techniques in Otolaryngology-Head and Neck Surgery.2026;[Epub]     CrossRef
  • Treatment of nodular goiter with compression of the neck organs in a step-by-step manner: sclerotherapy, radiofrequency ablation
    G. T. Gumerova, A. F. Fazlieva, S. P. Klimets, N. S. Suleymanova, A. I. Ishbulatova, I. V. Asfandiyarova, A. D. Neryakhin, V. A. Makariin, A. A. Uspenskaya
    Endocrine Surgery.2025; 18(4): 39.     CrossRef
  • Diagnostic accuracy of ultrasound in hyperthyroidism: A comprehensive review of recent studies
    Dawei Wang, Chao Xie, Xuena Zheng, Min Li
    Journal of Radiation Research and Applied Sciences.2025; 18(2): 101370.     CrossRef
  • Ultrasound (US)-guided ethanol ablation for cystic thyroid nodules: a comparison of the ethanol retention and aspiration techniques
    Amr Muhammad Abdo Salem, Mohamed El-Gharib Abou-Elmaaty, Mona Mohamed Abdelsalam Besibes, Mohamed Gamal Abdelmoteleb, Allam El-Sayed Allam
    Egyptian Journal of Radiology and Nuclear Medicine.2025;[Epub]     CrossRef
  • Does one session suffice? Evaluation of single-session ethanol ablation for thyroid cysts of varying sizes
    Wei-Shin Yu, Pin-Hsien Lai, Hsiang-Lin Lee, Yu-Hsun Wang, Chun-Lang Su, Yu-Shen Lee, Kai-Lun Cheng
    The American Journal of Surgery.2025; 248: 116519.     CrossRef
  • The First 100 Patients to Undergo Elective Ethanol Ablation of Thyroid Cysts in the East of Scotland
    Rosa Bock, Iain J. Nixon, Craig Hurnauth, David Summers, Helen Reid
    Clinical Otolaryngology.2025; 50(6): 1035.     CrossRef
  • Complications after thermal ablation for thyroid nodules across countries
    Shuang Wu, Yantao Cai, Xiaoyu Liu, Chenfang Zhu
    Frontiers in Endocrinology.2025;[Epub]     CrossRef
  • Interventional Radiology in Diagnosis and Treatment of Endocrine Diseases
    Ömer Faruk Topaloğlu, Onur Taydaş
    Türk Radyoloji Seminerleri.2025;[Epub]     CrossRef
  • Ultrasound-guided ethanol ablation versus the Sistrunk operation as a primary treatment for thyroglossal duct cysts
    Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee, Jin Ho Sohn
    Ultrasonography.2024; 43(1): 25.     CrossRef
  • The Comparison of Efficacy and Safety between Radiofrequency Ablation Alone and Ethanol Ablation Followed by Radiofrequency Ablation in the Treatment of Mixed Cystic and Solid Thyroid Nodule
    Min Gang Jo, Min Kyoung Lee, Jae Ho Shin, Min Guk Seo, So Lyung Jung
    Journal of the Korean Society of Radiology.2024; 85(3): 618.     CrossRef
  • Prevalence and Management of Complications of Percutaneous Ethanol Injection for Cystic Thyroid Nodules: A Systematic Review of Literature and Meta-analysis
    Lorenzo Scappaticcio, Pamela Ferrazzano, Nicole Di Martino, Roberto Negro, Maurilio Deandrea, Maria Ida Maiorino, Paola Caruso, Michela Di Nuzzo, Miriam Longo, Giovanni Docimo, Giampaolo Papi, Pierpaolo Trimboli, Katherine Esposito, Giuseppe Bellastella
    Thyroid®.2024; 34(9): 1068.     CrossRef
  • Current role of interventional radiology in thyroid nodules
    Onur Taydas, Erbil Arik, Omer Faruk Sevinc, Ahmet Burak Kara, Mustafa Ozdemir, Hasret Cengiz, Zulfu Bayhan, Mehmet Halil Ozturk
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Ethanol Ablation Is a Safe Treatment Option for Cystic and Predominantly Cystic Thyroid Nodules
    Iram Hussain
    Clinical Thyroidology®.2024; 36(11): 412.     CrossRef
  • Percutaneous Ethanol Sclerotherapy for Head-and-Neck Lymphatic Malformation: A Systematic Review and Case Report
    Xin Ler Pang, Stephanie He Shengjie, Man Hon Tang, Joel Lau Wen Liang, Wei Keat Cheah, Yi-Xiu Chua, Hui Seong Teh, Si Zhao Tang
    Journal of Endocrine Surgery.2024; 24(4): 119.     CrossRef
  • Ultrasound-Guided Ethanol Ablation for Thyroglossal Duct Cyst: A Review of Technical Issues and Potential as a New Standard Treatment
    Dongbin Ahn
    Journal of Clinical Medicine.2023; 12(17): 5445.     CrossRef
  • Ultrasound‐Guided Ethanol Ablation as a Primary Treatment for Thyroglossal Duct Cyst: Feasibility, Characteristics, and Outcomes
    Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee, Jin Ho Sohn
    Otolaryngology–Head and Neck Surgery.2023; 168(6): 1381.     CrossRef
  • Ultraschallgeführte lokalablative Verfahren zur Behandlung von Schilddrüsenläsionen
    Johannes-Paul Richter, Carl-Philip Richter, Daniel Gröner
    Angewandte Nuklearmedizin.2023; 46(02): 169.     CrossRef
  • A Case of Thyroid Abscess Following Ethanol Ablation for Benign Thyroid Nodule
    Heungrae Cho, Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(9): 624.     CrossRef
  • Sclerotherapy with a Viscum Album Extract for the Two Patients with Cystic Thyroid Nodule
    Jae Ha Lee, Seung Won Lee, Ki Nam Park
    International Journal of Thyroidology.2023; 16(1): 139.     CrossRef
  • Percutaneous ethanol injection in thyroid nodular pathology and metastatic cervical adenopathies: A systematic review, meta-analysis and economic evaluation
    Beatriz León-Salas, Aránzazu Hernández-Yumar, Diego Infante-Ventura, Aythami de Armas Castellano, Yadira González Hernández, Renata Linertová, Teresa Téllez Santana, Pedro de Pablos-Velasco, María M. Trujillo-Martín
    Endocrinología, Diabetes y Nutrición.2023; 70(9): 572.     CrossRef
  • Ultraschallgeführte lokalablative Verfahren zur Behandlung von Schilddrüsenläsionen
    Johannes-Paul Richter, Carl-Philip Richter, Daniel Gröner
    Laryngo-Rhino-Otologie.2023; 102(12): 916.     CrossRef
  • Percutaneous ethanol injection in thyroid nodular pathology and metastatic cervical adenopathies: A systematic review, meta-analysis and economic evaluation
    Beatriz León-Salas, Aránzazu Hernández-Yumar, Diego Infante-Ventura, Aythami de Armas Castellano, Yadira González Hernández, Renata Linertová, Teresa Téllez Santana, Pedro de Pablos-Velasco, María M. Trujillo-Martín
    Endocrinología, Diabetes y Nutrición (English ed.).2023; 70(9): 572.     CrossRef
  • Safety and Efficacy of Ultrasound-Guided Radiofrequency Ablation for Benign Nonfunctional Thyroid Nodules in Children: A Retrospective Study of 62 Patients with Over Four Years of Follow-Up
    Liwen Li, Xinguang Qiu
    Thyroid®.2022; 32(5): 525.     CrossRef
  • Ethanol ablation for the treatment of benign thyroid nodules
    Gabrielle K. Steinl, Latoya A. Stewart, Catherine McManus, James A. Lee, Jennifer H. Kuo
    The American Journal of Surgery.2022; 224(1): 408.     CrossRef
  • Minimally-invasive treatments for benign thyroid nodules: recommendations for information to patients and referring physicians by the Italian Minimally-Invasive Treatments of the Thyroid group
    Giovanni Mauri, Stella Bernardi, Andrea Palermo, Roberto Cesareo, Enrico Papini, Luigi Solbiati, Daniele Barbaro, Salvatore Monti, Maurilio Deandrea, Laura Fugazzola, Giovanni Gambelunghe, Roberto Negro, Stefano Spiezia, Fulvio Stacul, Luca Maria Sconfien
    Endocrine.2022; 76(1): 1.     CrossRef
  • Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors
    Arian Mansur, Tushar Garg, Apurva Shrigiriwar, Vahid Etezadi, Christos Georgiades, Peiman Habibollahi, Timothy C. Huber, Juan C. Camacho, Sherif G. Nour, Alan Alper Sag, John David Prologo, Nariman Nezami
    Diagnostics.2022; 12(6): 1300.     CrossRef
  • Approach to FNA of Thyroid Gland Cysts
    Esther Diana Rossi, Pietro Tralongo, Vincenzo Fiorentino, Mariangela Curatolo, Carmine Bruno, Carmen De Crea, Marco Raffaelli, Alfredo Pontecorvi, Luigi Maria Larocca
    Advances in Anatomic Pathology.2022; 29(6): 358.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism
TOP