Endocrinology and Metabolism

Original Articles

Persistent Adipose Inflammation Despite Metabolic Recovery Reveals Tissue-Specific Immunomodulation by Tirzepatide: Mihye Seo, Maria Averia, Vivi Julietta, Shindy Soedono, Esther Jin Joo, Ellen Budiono, Minjoon Lee, Min-Kyu Kim, Yongsung Hwang, Hyeong Kyu Park, Kyoil Suh, Kae Won Cho; Received November 3, 2025 Accepted January 15, 2026 Published online May 15, 2026; DOI: https://doi.org/10.3803/EnM.2025.2766 [Epub ahead of print]

3,637 View
157 Download

Abstract PDF Supplementary Material PubReader ePub: Background
Obesity is characterized by chronic inflammation and fibrosis of adipose tissue; however, the extent to which these pathological features persist during pharmacologically induced weight loss remains poorly understood. This study investigated the effects of tirzepatide, a dual agonist of the glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors, on adipose tissue inflammation and fibrosis in obese mice.
Methods
Diet-induced obesity was treated with tirzepatide or vehicle for 25 days. Metabolic parameters, tissue inflammation, fibrosis, and macrophage activation were assessed using histology, flow cytometry, gene expression analyses, and immunoblotting. In vitro experiments were conducted to compare the effects of tirzepatide on classically activated and metabolically activated macrophages.
Results
Tirzepatide significantly reduced body weight and adiposity, increased energy expenditure, and upregulated thermogenic and mitochondrial proteins in brown adipose tissue. Hyperglycemia and glucose intolerance were normalized. However, adipose tissue inflammation and fibrosis persisted despite weight loss, as evidenced by sustained immune cell infiltration, collagen deposition, and activation of Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) signaling. In contrast, hepatic inflammation and fibrosis were substantially improved. Mechanistically, tirzepatide suppressed inflammatory gene expression in classically activated macrophages but not in metabolically activated macrophages, suggesting that the local metabolic context determines tissue responsiveness to its anti-inflammatory actions.
Conclusion
Tirzepatide exerts distinct tissue-specific effects on inflammation and fibrosis during weight loss, ameliorating hepatic pathology while sparing adipose tissue inflammation. These findings identify metabolically activated macrophages as potential determinants of tissue-specific inflammatory persistence and underscore the need for therapeutic strategies that target macrophage activation and fibrotic remodeling to achieve durable metabolic benefits during pharmacological weight loss.

YTHDF1-Mediated m⁶A Modification of lncRNA OIP5-AS1 Exacerbates Macrophage Metabolic Dysfunction in Diabetes Mellitus with Coronary Artery Disease: Hongjie Wang, Luyao Li, Zhen Zhen, Zheqi Zhang, Ya Su, Bo Li; Received July 21, 2025 Accepted December 15, 2025 Published online May 7, 2026; DOI: https://doi.org/10.3803/EnM.2025.2566 [Epub ahead of print]

976 View
19 Download

Abstract PDF Supplementary Material PubReader ePub: Background
Diabetes mellitus (DM) with coronary artery disease (CAD), referred to as DM-CAD, is a prevalent endocrine-metabolic condition characterized by macrophage-driven inflammation and metabolic dysregulation. This study aims to investigate the role of YTH N6-methyladenosine RNA binding protein F1 (YTHDF1)-mediated N⁶-methyladenosine (m⁶A) modification in stabilizing the long non-coding RNA (lncRNA) Opa interacting protein 5 antisense RNA 1 (OIP5-AS1) and to determine its impact on macrophage metabolic dysfunction in DM-CAD.
Methods
Single-cell RNA sequencing and bulk RNA sequencing were performed using DM-CAD mouse models, with downstream analyses conducted using Seurat, CellChat, least absolute shrinkage and selection operator (LASSO) regression, and random forest algorithms. Experimental validation included RNA immunoprecipitation followed by quantitative polymerase chain reaction, actinomycin D-based RNA stability assays, and 2-deoxyglucose (2-DG) interventions in THP-1–derived macrophages, alongside metabolomic profiling and reactive oxygen species (ROS) measurements.
Results
Increased macrophage-endothelial cell coupling was observed in DM-CAD, with both OIP5-AS1 and YTHDF1 significantly upregulated and closely associated with glycolytic metabolic pathways. YTHDF1-mediated m⁶A modification stabilized OIP5-AS1, thereby promoting glycolysis, foam cell formation, ROS production, plaque development, and the upregulation of proinflammatory cytokines, collectively exacerbating atherosclerosis. Notably, treatment with 2-DG markedly reversed these pathological phenotypes.
Conclusion
This study identifies the YTHDF1–m⁶A–OIP5-AS1 axis as a critical regulator of macrophage metabolic dysfunction in DM-CAD, thereby providing an epigenetic framework for understanding disease progression. Targeting this regulatory pathway may attenuate metabolic inflammation and represents a promising therapeutic strategy for endocrine-related cardiovascular complications.

Diabetes, Obesity and Metabolism
The Effects of Irisin on the Interaction between Hepatic Stellate Cell and Macrophage in Liver Fibrosis: Dinh Vinh Do, So Young Park, Giang Thi Nguyen, Dae Hee Choi, Eun-Hee Cho; Endocrinol Metab. 2022;37(4):620-629. Published online July 22, 2022; DOI: https://doi.org/10.3803/EnM.2022.1412

11,421 View
248 Download
15 Web of Science
13 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Hepatic stellate cells (HSCs) are the central players interacting with multiple cell types in liver fibrosis. The crosstalk between HSCs and macrophages has recently become clearer. Irisin, an exercise-responsive myokine, was known to have a potentially protective role in liver and renal fibrosis, especially in connection with stellate cells. This study investigated the effects of irisin on the interaction between HSCs and macrophages.
Methods
Tamm-Horsfall protein-1 (THP-1) human monocytes were differentiated into macrophages, polarized into the inflammatory M1 phenotype with lipopolysaccharide. Lieming Xu-2 (LX-2) cells, human HSCs, were treated with conditioned media (CM) from M1 macrophages, with or without recombinant irisin. HSCs responses to CM from M1 macrophages were evaluated regarding activation, proliferation, wound healing, trans-well migration, contractility, and related signaling pathway.
Results
CM from M1 macrophages significantly promoted HSC proliferation, wound healing, transwell migration, and contractility, but not activation of HSCs. Irisin co-treatment attenuated these responses of HSCs to CM. However, CM and irisin treatment did not induce any changes in HSC activation. Further, irisin co-treatment alleviated CM-induced increase of phopho-protein kinase B (pAKT), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinases-1 (TIMP-1).
Conclusion
These findings suggested that irisin may play a protective role in the pathogenesis of liver fibrosis, especially when working in the crosstalk between HSCs and macrophages.

Citations

Citations to this article as recorded by

Interactions between hepatic stellate cells and immune cells: Implications for liver fibrosis
Deyu Xie, Yihui Huang, Yitian Yu, Weikai Jin, Xiangting Zhang, Fujun Yu
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2026; 1872(1): 168062. CrossRef
Sepsis: Heterogeneity, Immunopathology, and Advances in Therapeutic Strategies
Junxing Qu, Peizhi Li, Zhiheng Sun
The FASEB Journal.2026;[Epub] CrossRef
Pomolic acid alleviates CCl4‑induced liver fibrosis in mice by suppressing β-arrestin 2-mediated pro-fibrotic macrophage polarization
Xuan Zhu, Yuhan Zhou, Mingyu Ruan, Xuebin Yang, Gang Pei, Jin Tan
Scientific Reports.2026;[Epub] CrossRef
Loss of immunometabolic adaptability in MASH: gut-derived signals drive macrophage reprogramming and fibrosis
Yan Li, Yuyuan Hu, Yuan He, Yuhang Yang, Dingwen Xue, Erkui Xue, Jinghan Jia, Wei Zhang, Jinxi Wang
Frontiers in Immunology.2026;[Epub] CrossRef
Exercise‐Induced Irisin Antagonizes TGFBR2 to Attenuate Islet Fibrosis and Improve Glucose Homeostasis in Type 2 Diabetes
Qianqian Wang, Xiaohang Wang, Zhensheng Cai, Vladmir Carvalho, Huan Wang, Yang Chen, Zilin Sun, Shanhu Qiu
The FASEB Journal.2026;[Epub] CrossRef
Letter to the Editor: Improving the reliability of functional capacity testing in liver cirrhosis: A novel assessment direction
Marwan SM Al-Nimer
World Journal of Hepatology.2026;[Epub] CrossRef
Irisin and Metastatic Melanoma: Selective Anti-Invasiveness Activity in BRAF Wild-Type Cells
Simona Serratì, Roberta Zerlotin, Michele Manganelli, Roberta Di Fonte, Manuela Dicarlo, Angela Oranger, Graziana Colaianni, Letizia Porcelli, Amalia Azzariti, Stefania Guida, Maria Grano, Silvia Concetta Colucci, Gabriella Guida
International Journal of Molecular Sciences.2025; 26(2): 652. CrossRef
Myokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance
Jia Yi, Junyang Chen, Xinlei Yao, Zihao Zhao, Xinxin Niu, Xia Li, Jiacheng Sun, Yanan Ji, Tongxin Shang, Leilei Gong, Bingqian Chen, Hualin Sun
Biochemical Pharmacology.2025; 242: 117326. CrossRef
The potential of flavonoids in hepatic fibrosis: A comprehensive review
Zhu Wenbo, Han Jianwei, Liu Hua, Tang Lei, Chen Guijuan, Tian Mengfei
Phytomedicine.2024; 133: 155932. CrossRef
Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction
Thuy Linh Lai, So Young Park, Giang Nguyen, Phuc Thi Minh Pham, Seon Mee Kang, Jeana Hong, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho
Endocrinology and Metabolism.2024; 39(6): 908. CrossRef
Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Biomedicine & Pharmacotherapy.2023; 161: 114472. CrossRef
Potential role of irisin in digestive system diseases
Yueming Zhang, Linxian Zhao, Huan Gao, Jinghui Zhai, Yanqing Song
Biomedicine & Pharmacotherapy.2023; 166: 115347. CrossRef
The effect of sarcopenia and serum myokines on prognosis and survival in cirrhotic patients: a multicenter cross-sectional study
Salih Boga, Abdullah Emre Yildirim, Enver Ucbilek, Ali Riza Koksal, Sevil Tokdemir Sisman, Ibrahim Durak, Ilker Sen, Beril Dogu, Erdinc Serin, Ayse Bolat Ucbilek, Makbule Ozge Yildirim, Sukru Mehmet Erturk, Huseyin Alkim, Canan Alkim
European Journal of Gastroenterology & Hepatology.2022; 34(12): 1261. CrossRef

Namgok Lecture 2020

Diabetes, Obesity and Metabolism
Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress: Min Jeong Choi, Saet-Byel Jung, Joon Young Chang, Minho Shong; Endocrinol Metab. 2021;36(1):1-11. Published online February 24, 2021; DOI: https://doi.org/10.3803/EnM.2021.956

10,890 View
255 Download
5 Web of Science
5 Crossref

Abstract PDF PubReader ePub

Paracrine interactions are imperative for the maintenance of adipose tissue intercellular homeostasis, and intracellular organelle dysfunction results in local and systemic alterations in metabolic homeostasis. It is currently accepted that mitochondrial proteotoxic stress activates the mitochondrial unfolded protein response (UPR^mt) in vitro and in vivo. The induction of mitochondrial chaperones and proteases during the UPR^mt is a key cell-autonomous mechanism of mitochondrial quality control. The UPR^mt also affects systemic metabolism through the secretion of cell non-autonomous peptides and cytokines (hereafter, metabokines). Mitochondrial function in adipose tissue plays a pivotal role in whole-body metabolism and human diseases. Despite continuing interest in the role of the UPR^mt and quality control pathways of mitochondria in energy metabolism, studies on the roles of the UPR^mt and metabokines in white adipose tissue are relatively sparse. Here, we describe the role of the UPR^mt in adipose tissue, including adipocytes and resident macrophages, and the interactive roles of cell non-autonomous metabokines, particularly growth differentiation factor 15, in local adipose cellular homeostasis and systemic energy metabolism.

Citations

Citations to this article as recorded by

The role and mechanism of UPRmt in adipocytes
Hao Liu, Jie Chen, Dan-Qi Qiu, Miao-Wei Jiang, Hao-Qi Chen, Li Li, Shu-Qin Chen
Adipocyte.2026;[Epub] CrossRef
From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit
Masaru Tanaka, László Vécsei
Biomedicines.2025; 13(8): 2020. CrossRef
Imeglimin modulates mitochondria biology and facilitates mitokine secretion in 3T3-L1 adipocytes
Nobuhiko Takahashi, Atsushi P. Kimura, Takayuki Yoshizaki, Kazumasa Ohmura
Life Sciences.2024; 349: 122735. CrossRef
Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior
Carla Igual Gil, Bethany M Coull, Wenke Jonas, Rachel N Lippert, Susanne Klaus, Mario Ost
Life Science Alliance.2022; 5(11): e202201495. CrossRef
Stress-induced FGF21 and GDF15 in obesity and obesity resistance
Susanne Keipert, Mario Ost
Trends in Endocrinology & Metabolism.2021; 32(11): 904. CrossRef

Original Article

Clinical Study
Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment: Oksana Sulaieva, Olena Chernenko, Oleksiy Selesnov, Oleksandr Nechay, Oleksandr Maievskyi, Tetyana Falalyeyeva, Nazarii Kobyliak, Olena Tsyryuk, Yurii Penchuk, Dmytro Shapochka; Endocrinol Metab. 2020;35(2):443-455. Published online June 24, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.2.443

11,933 View
204 Download
26 Web of Science
27 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
The relationship between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains uncertain. We assessed the impact of HT on the tumor immune microenvironment (TIME) in PTC.
Methods
Thirty patients with PTC (group 1) and 30 patients with PTC and HT (group 2) were enrolled in this pilot study. The distribution and number of CD8+ lymphocytes, plasma cells (CD138+), regulatory T cells (forkhead box P3 [FOXP3+)], mast cell tryptase (MCT+), and M2 macrophages (CD163+) were evaluated. To test the hypothesis that HT impacts PTC development via signal transducer and activator of transcription 6 (STAT6) activation and M2 macrophage polarization, we investigated STAT6 expression in tumor and stromal cells. We also evaluated vascular endothelial growth factor (VEGF) expression by lymph node metastasis (LNM) status.
Results
TIME showed significant between-group differences. Group 1 patients demonstrated immune desert or immune-excluded immunophenotypes, while an inflamed phenotype with more CD8+ cells (P<0.001) predominated in group 2. Immune-excluded TIME was associated with the highest LNM rate. In PTC, LNM was associated with more numerous CD163+ cells. Moreover, LNM in group 1 was associated with increased numbers of mast cells peritumorally and FOXP3+ cells intratumorally and peritumorally. Group 2 demonstrated higher STAT6 but not higher VEGF expression in tumor cells. High VEGF expression was associated with LNM regardless of HT status.
Conclusion
Concomitant HT impacted PTC signaling via STAT6 and TIME by increasing the number of CD8+ cells. LNM is associated with increases in CD163+ cells and VEGF expression in PTC, whereas HT affected LNM through different mechanisms.

Citations

Citations to this article as recorded by

Papillary Thyroid Carcinoma and Hashimoto’s Thyroiditis: New Insights into the Immunological Link
Patricia Schott-Ohly, Matthias Schott
Hormone and Metabolic Research.2026; 58(02): 43. CrossRef
Integrating multi-omics and machine learning to unravel mechanisms of lymph node metastasis in papillary carcinoma with and without thyroiditis
Shuran Chen, Wencan Yang, Yanyan Liu, Angqing Li
Frontiers in Immunology.2026;[Epub] CrossRef
Impact of Hashimoto Thyroiditis on Long-Term Outcomes in Differentiated Thyroid Carcinoma
Jasna Mihailović, Ivana Starčević, Slađana Novković-Ostojić, Tijana Vasiljević, Nataša Prvulović Bunović, Bojana Šćepanović
Cancers.2026; 18(12): 1938. CrossRef
Immune cells in thyroid adenoma and carcinoma: uncovering a hidden value of assessing tumor-host interplay and its potential application in thyroid cytopathology
Iryna Omelianenko, Nazarii Kobyliak, Tetyana Falalyeyeva, Oleksii Seleznov, Pavlina Botsun, Lyudmila Ostapchenko, Oleksandr Korotkyi, Liudmyla Domylivska, Olena Tsyryuk, Galyna Mykhalchyshyn, Tetiana Shapochka, Oksana Sulaieva
Frontiers in Molecular Biosciences.2025;[Epub] CrossRef
Exploring the mechanism of vitamin C on the co-expressed genes of papillary thyroid carcinoma and Epstein-Barr virus based on bioinformatics, network pharmacology and molecular docking analysis
Dongliang Shi, Liang Chen, Chenhao Li, Meng Yang, Wenhua Yang, Guozhong Cui, Jinzhao Liu, Qianqian Chen
Discover Oncology.2025;[Epub] CrossRef
Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlation
Shengpeng Yao, Hong Zhang
Frontiers in Endocrinology.2025;[Epub] CrossRef
Mechanisms underlying the promotion of papillary thyroid carcinoma occurrence and progression by Hashimoto’s thyroiditis
Xiaohui Xue, Deqi Wu, Hangyu Yao, Kainan Wang, Zhengtao Liu, Haijiang Qu
Frontiers in Endocrinology.2025;[Epub] CrossRef
Research Progress on the Immunological Correlation Between Papillary Thyroid Carcinoma and Hashimoto’s Thyroiditis
Digui Fang, Limei Zhou, Biao Zheng, Ran Wang
Journal of Immunology Research.2025;[Epub] CrossRef
Risk Stratification for Thyroid Malignancies in Chronic Lymphocytic Thyroiditis
Anna Krzentowska, Aleksander Konturek, Filip Gołkowski, Anna Merklinger-Gruchała, Marcin Barczyński
Cancers.2025; 17(12): 1964. CrossRef
Developments in the study of the role of lactate metabolism in the genesis and progression of thyroid cancer
Lei Shi, Xuyang Zhong, Jiafeng Liu, Yong Ying, Zibing Liao, Jin Liu, Liwen Zhao, Jianing Zhong, Xiangtai Zeng
Frontiers in Cell and Developmental Biology.2025;[Epub] CrossRef
Genetic alterations affect immune contexture of non-small cell lung cancer: Ukrainian study
Denys Kozakov, Nazarii Kobyliak, Sofiia Livshun, Oleksii Seleznov, Olena Koshyk, Alina Matvieieva, Yaroslav Shparyk, Oleksii Kolesnik, Yuliia Moskalenko, Oleksandr Vynnychenko, Roman Moskalenko, Serhii Kropyvko, Anna Khmel, Bogdana Shkarupii, Oksana Sulai
Frontiers in Medicine.2025;[Epub] CrossRef
The impact of Hashimoto’s thyroiditis on the clinical outcome of papillary thyroid cancer after radioactive iodine therapy: a propensity score matching study
Jingjia Cao, Yaru Sun, Yang Liu, Yunfei Xu, Xiao Li, Wei Zhang, Ximing Wang
Endocrine.2024; 87(1): 178. CrossRef
Prognostic role of STAT6 in patients with non-small cell lung cancer
O. Vynnychenko, Y. Moskalenko, O. Yazykov, I. Tymchenko, O. Seleznov, O. Sulaieva, R. Moskalenko
Regulatory Mechanisms in Biosystems.2024; 15(4): 868. CrossRef
Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer
Tairong Liang, Xiuqian Wu, Lan Wang, Zhengzhong Ni, Ying Fan, Peishan Wu, Hongzhi Wang, Yongdong Niu, Haihua Huang
Pathology - Research and Practice.2023; 245: 154431. CrossRef
Recommend with caution: A meta-analysis investigating papillary thyroid carcinoma tumor progression under active surveillance
Peter P. Issa, Ruhul Munshi, Aaron L. Albuck, Mahmoud Omar, Ruba F. Abu Alhuda, Tyler Metz, Mohammad Hussein, Mohamed Shama, Grace S. Lee, Eman Toraih, Emad Kandil
American Journal of Otolaryngology.2023; 44(6): 103994. CrossRef
Hashimoto's thyroiditis is negatively associated with lymph node metastasis in PTMC
Hui Huang, Siyuan Xu, Song Ni, Wensheng Liu, Shaoyan Liu
Journal of Cancer Research and Clinical Oncology.2023; 149(17): 15525. CrossRef
A nomogram based on the risk factors of cervical lymph node metastasis in papillary thyroid carcinoma coexistent with Hashimoto’s thyroiditis
Huanhuan Miao, Jingwen Zhong, Xuesha Xing, Jiawei Sun, Jiaqi Wu, Chengwei Wu, Yan Yuan, Xianli Zhou, Hongbo Wang
Clinical Hemorheology and Microcirculation.2023; 85(3): 235. CrossRef
The role of vascular endothelial growth factor in the development of papillary thyroid carcinoma in patients with lymphocytic thyroiditis
Nese E. GULCELIK, Safak AKIN, Kadriye AYDIN, Cisel AYDIN MERICOZ, Yesim G. GULER TEZEL, Aydan USMAN
Minerva Endocrinology.2023;[Epub] CrossRef
Identification of Transcriptional Pattern Related to Immune Cell Infiltration With Gene Co-Expression Network in Papillary Thyroid Cancer
Meiye Li, Jimei Zhang, Zongjing Zhang, Ying Qian, Wei Qu, Zhaoshun Jiang, Baochang Zhao
Frontiers in Endocrinology.2022;[Epub] CrossRef
A Potential Nine-lncRNAs Signature Identification and Nomogram Diagnostic Model Establishment for Papillary Thyroid Cancer
Jin-Ming Yao, Jun-Yu Zhao, Fang-Fang Lv, Xue-Bo Yang, Huan-Jun Wang
Pathology and Oncology Research.2022;[Epub] CrossRef
Hyperhomocysteinemia in the pathogenesis of cardiovascular and endocrine diseases: translational messages
Rostyslav KAMINSKY, Andrii YANCHYSHYN, Natalia BELEMETS, Olena KURYK, Inga SAMBORSKA, Iryna DZEVULSKA, Rinaldo PELLICANO
Minerva Biotechnology and Biomolecular Research.2022;[Epub] CrossRef
Immune Microenvironment of Muscular-Invasive Urothelial Carcinoma: The Link to Tumor Immune Cycle and Prognosis
Oleksandr Stakhovskyi, Nazarii Kobyliak, Oleg Voylenko, Eduard Stakhovskyi, Roman Ponomarchuk, Oksana Sulaieva
Cells.2022; 11(11): 1802. CrossRef
Comprehensive analysis of lncRNA-mediated ceRNA regulatory networks and key genes associated with papillary thyroid cancer coexistent with Hashimoto’s thyroiditis
Yuepeng Zhang, Yueli Tian
BMC Endocrine Disorders.2022;[Epub] CrossRef
Research Progress in the Correlation between AID, BRAFV600E and Papillary Thyroid Carcinoma
鑫焦
Advances in Clinical Medicine.2022; 12(12): 11503. CrossRef
STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology
Georgia Karpathiou, Alexandra Papoudou-Bai, Elise Ferrand, Jean Marc Dumollard, Michel Peoc’h
Pathology - Research and Practice.2021; 223: 153477. CrossRef
Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes
Siyuan Xu, Hui Huang, Jiaxin Qian, Yang Liu, Ying Huang, Xiaolei Wang, Shaoyan Liu, Zhengang Xu, Jie Liu
JAMA Network Open.2021; 4(7): e2118526. CrossRef
LARINGOPHARINGEAL REFLUX IMPACTS IMMUNE MICROENVIRONMENT OF LARYNGEAL CARCINOMA
D.I. Zabolotnyi, V.V. Kizim, D.D. Zabolotna, Y.V. Kizim, O.N. Sulaieva
Fiziolohichnyĭ zhurnal.2020; 66(4): 12. CrossRef

Review Article

The Role of Macrophage Lipophagy in Reverse Cholesterol Transport: Se-Jin Jeong, Mi-Ni Lee, Goo Taeg Oh; Endocrinol Metab. 2017;32(1):41-46. Published online March 20, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.1.41

11,926 View
113 Download
48 Web of Science
51 Crossref

Abstract PDF PubReader

Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.

Citations

Citations to this article as recorded by

Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)
Yongchun Liang, Xinbiao Fan, Xiaofei Geng, Yunfeng Jia, Wenyu Shang, Xitong Sun, Jun Ge, Guijun Ye, Boyu Zhu, Zheng Zhang, Yuxin Kang, Xiaoyu Shan, Junping Zhang
International Journal of Molecular Medicine.2026; 57(4): 1. CrossRef
Expression of IMD-CBM peptide induces the autophagic degradation of CAV1 (caveolin 1) to inhibit LDL transcytosis and retard diabetic atherosclerosis
Li Wang, Xiong Jia, Xiangli Bai, Ying Zhao, Wenzhuo Cheng, Meng Shu, Yan Shu, Liyin Zhang, Ruonan Wang, Si Jin
Autophagy.2026; 22(6): 1273. CrossRef
The role of selective autophagy in cardiovascular diseases: mechanisms and therapeutic potential
Ting Zeng, Zhongjian Zhang, Chunliu Qian, Xiaoyu Li, Shuang Li
The Journal of Cardiovascular Aging.2026;[Epub] CrossRef
Hexosamine Biosynthetic Pathway and Fatty Acid β-Oxidative Imbalance: A Key Mechanism by Which Abnormal Macrophage Lipophagy Promotes Atherosclerosis in Diabetes
Jin-ping Liu, Yu-hui Liu, Hao Luo, Yi-fei Wu, Shuai-yi Yu, Ya Wu, Yong Liu
Cardiovascular Drugs and Therapy.2026;[Epub] CrossRef
Phospholipid Transfer Protein (PLTP) in Cholesterol Handling: Implications for Mitochondrial Lipid Homeostasis in Human iPSC-Derived Cardiomyocytes
Dhienda C. Shahannaz, Tadahisa Sugiura
International Journal of Molecular Sciences.2026; 27(8): 3617. CrossRef
Dual modulation of lipophagy: From molecular mechanisms to therapeutic interventions in cardiovascular health and disease
Yunxia Wu, Weili Li, Heng Liu, Fei Ge, Guanjing Ling, Yawen Zhang, Yuqin Zhang, Yilin Li, Yan Wei, Shujuan Guo, Wei Wang, Yong Wang
Pharmacological Research.2026; 228: 108204. CrossRef
Fatty acid metabolism and lipid channeling in macrophages: mechanisms of inflammation, resolution, and lipotoxicity
Temitayo T. Bamgbose, Oluwakemi O. Igiehon, Javier Nion-Fieira, Cora R. Palmer, Andrii Andriichuk, Matthew D. Woolard
Frontiers in Immunology.2026;[Epub] CrossRef
From lipid overload to autophagy collapse: how lipid dysregulation drives chronic inflammation and metabolic disease
Mykyta Fomin, Konstantin Zapf, Elisabeth Schieffer, Johannes Freitag, Gert Bange, Bernhard Schieffer
Inflammation Research.2026;[Epub] CrossRef
Protective Effect of Natural Phenolic Acids, Rosmarinic Acid and Salvianolic Acid, Against Diabetic Atherosclerosis
Yaeram Won, Hye Jung Kim
International Journal of Molecular Sciences.2026; 27(15): 6625. CrossRef
Sex-specific transcriptional regulation in lung macrophages during sub-acute Mycobacterium tuberculosis infection
Dhanya Dhanyalayam, Hariprasad Thangavel, Kezia Lizardo, Jigar V. Desai, Jyothi F. Nagajyothi, Prabagaran Narayanasamy
Microbiology Spectrum.2025;[Epub] CrossRef
Tianxiangdan suppresses foam cell formation by enhancing lipophagy and reduces the progression of atherosclerosis
Ya-jie Zhang, Huan He, Guligena Sawuer, Xue-kuan Ma, Zulihumaer Ainiwaer, Dan-dan Wu, Xia-xia Zhang, Dong-qing An
In Vitro Cellular & Developmental Biology - Animal.2025; 61(3): 298. CrossRef
Cellular stress and macrophage activation
Jing Yu, Bin-Zhi Qian
Seminars in Immunology.2025; 78: 101953. CrossRef
The converging roles of microRNAs and lipid metabolism in atherosclerotic cardiovascular disease and cancer
Sandra Vladimirov, Marija Tomasevic, Nemanja Popov, Jelena Munjas, David de Gonzalo-Calvo, Miron Sopic
Seminars in Cancer Biology.2025; 114: 41. CrossRef
ApoA1-driven cholesterol efflux and macrophage polarization orchestrate T-cell differentiation towards controlling Leishmania donovani pathogenesis
Vikash Kumar, Dayakar Alti, Shobha Kumari, Ravi Ranjan, Divya Prasad, Veer Singh, Abhik Sen, Pradeep Das, Krishna Pandey, Ashish Kumar
Scientific Reports.2025;[Epub] CrossRef
The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases
Yuchang Li, Liting Chen, Vassilios Papadopoulos
Biochimie.2024; 224: 91. CrossRef
Bile salt signaling and bile salt-based therapies in cardiometabolic disease
Claire C.J. Groenen, Thuc-Anh Nguyen, Coen C. Paulusma, Stan F.J. van de Graaf
Clinical Science.2024; 138(1): 1. CrossRef
Insights into the role of FGF21 in coronary heart disease
Qin-Yao Zhang, Hui-Xin Liu
International Journal of Biological Macromolecules.2024; 282: 136911. CrossRef
Mechanistic insights into the regression of atherosclerotic plaques
Jianshu Song, Ce Cao, Ziyan Wang, Haoran Li, Lili Yang, Jing Kang, Hongxu Meng, Lei Li, Jianxun Liu
Frontiers in Physiology.2024;[Epub] CrossRef
Huazhuotongmai decoction exerts anti-atherosclerotic effects by modulating the expression of ABCA1/SR-B1/PPAR-γ in vivo and in vitro
Ya-ru Yan, Zi-jun Jia, Ya Wang, Feng-qin Xu, Qing-bing Zhou
Phytomedicine Plus.2023; 3(2): 100436. CrossRef
The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy
Hongping Chen, Da Teng, Bowen Xu, Chunxiao Wang, Hua Wang, Wenjuan Jia, Lei Gong, Haibin Dong, Lin Zhong, Jun Yang
Journal of Cardiovascular Translational Research.2023; 16(5): 999. CrossRef
FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy
Hongping Chen, Lihui Zhang, Shaohua Mi, Hua Wang, Chunxiao Wang, Wenjuan Jia, Lei Gong, Haibin Dong, Bowen Xu, Yanyan Jing, Peipei Ge, Zhigang Pei, Lin Zhong, Jun Yang
The FASEB Journal.2023;[Epub] CrossRef
Unbalanced Redox With Autophagy in Cardiovascular Disease
Se-Jin Jeong, Goo Taeg Oh
Journal of Lipid and Atherosclerosis.2023; 12(2): 132. CrossRef
Edible Bird’s Nest Effectively Attenuates Atherosclerosis through Modulation of Cholesterol Metabolism via Activation of PPARγ/LXRα Signaling Pathway In Vivo
Nurul Nadiah Mohamad Nasir, Ramlah Mohamad Ibrahim, Rozi Mahmud, Nor Asma Ab Razak, Norsharina Ismail, Kim Wei Chan, Md Zuki Abu Bakar, Akhilesh K. Verma
Journal of Food Biochemistry.2023; 2023: 1. CrossRef
The Differential Metabolomes in Cumulus and Mural Granulosa Cells from Human Preovulatory Follicles
Er-Meng Gao, Bongkoch Turathum, Ling Wang, Di Zhang, Yu-Bing Liu, Rong-Xin Tang, Ri-Cheng Chian
Reproductive Sciences.2022; 29(4): 1343. CrossRef
PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways
Keerthana Balamurugan, Raghavender Medishetti, Jyothi Kotha, Parameshwar Behera, Kanika Chandra, Vijay Aditya Mavuduru, Manjunath B. Joshi, Ramesh Samineni, Madhumohan R. Katika, Writoban Basu Ball, Manjunatha Thondamal, Anil Challa, Kiranam Chatti, Kisho
iScience.2022; 25(2): 103766. CrossRef
Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism
Xiumei Ke, Ruoyu Zhang, Pan Li, Ling Zuo, Meng Wang, Junxuan Yang, Jianwei Wang
Biochemical and Biophysical Research Communications.2022; 610: 49. CrossRef
Metabolic Regulation of Macrophage Activation
Ourania Kolliniati, Eleftheria Ieronymaki, Eleni Vergadi, Christos Tsatsanis
Journal of Innate Immunity.2022; 14(1): 51. CrossRef
Emerging Roles of Lipophagy in Cancer Metastasis
Haimeng Yin, Ying Shan, Tian Xia, Yan Ji, Ling Yuan, Yiwen You, Bo You
Cancers.2022; 14(18): 4526. CrossRef
Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies
Khairul Anwar Zarkasi, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Norfazilah Ahmad, Rahman Jamal
Diagnostics.2022; 12(10): 2561. CrossRef
Caveolin-1 in autophagy: A potential therapeutic target in atherosclerosis
Kai Hou, Shuai Li, Meng Zhang, Xuping Qin
Clinica Chimica Acta.2021; 513: 25. CrossRef
Contradictory regulation of macrophages on atherosclerosis based on polarization, death and autophagy
Jing Zhang, Chuan-Rui Ma, Yun-Qing Hua, Lan Li, Jing-Yu Ni, Yu-Ting Huang, Sophia Esi Duncan, Sheng Li, Shan Gao, Guan-Wei Fan
Life Sciences.2021; 276: 118957. CrossRef
A meta-analysis of HDL cholesterol efflux capacity and concentration in patients with rheumatoid arthritis
Binbin Xie, Jiang He, Yong Liu, Ting Liu, Chaoqun Liu
Lipids in Health and Disease.2021;[Epub] CrossRef
Rosmarinic Acid Increases Macrophage Cholesterol Efflux through Regulation of ABCA1 and ABCG1 in Different Mechanisms
Jean-Baptiste Nyandwi, Young Shin Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Hye Jung Kim
International Journal of Molecular Sciences.2021; 22(16): 8791. CrossRef
FGF21 induces autophagy‐mediated cholesterol efflux to inhibit atherogenesis via RACK1 up‐regulation
Lin Xiaolong, Guo Dongmin, Mihua Liu, Wang Zuo, Hu Huijun, Tan Qiufen, Hu XueMei, Lin Wensheng, Pan Yuping, Lin Jun, Zeng Zhaolin
Journal of Cellular and Molecular Medicine.2020; 24(9): 4992. CrossRef
Lipophagy in atherosclerosis
Qing Liu, Yuan-Mei Wang, Hong-Feng Gu
Clinica Chimica Acta.2020; 511: 208. CrossRef
Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies
Tatiana A. Korolenko, Thomas P. Johnston, Vaclav Vetvicka
Molecules.2020; 25(21): 5052. CrossRef
LncRNA MALAT1 Enhances ox-LDL-Induced Autophagy through the SIRT1/MAPK/NF-κB Pathway in Macrophages
Jiaqi Yang, Xuze Lin , Liangshan Wang, Tienan Sun, Qi Zhao, Qian Ma, Yujie Zhou
Current Vascular Pharmacology.2020; 18(6): 652. CrossRef
Autophagy in chronic stress induced atherosclerosis
Na Li, Ru-Xin Zhang, Xue-Jiao Xie, Hong-Feng Gu
Clinica Chimica Acta.2020; 503: 70. CrossRef
CTRP13 inhibits atherosclerosis via autophagy‐lysosome‐dependent degradation of CD36
Cheng Wang, Wenjing Xu, Minglu Liang, Dan Huang, Kai Huang
The FASEB Journal.2019; 33(2): 2290. CrossRef
Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagy
P. Saliba‐Gustafsson, M. Pedrelli, K. Gertow, O. Werngren, V. Janas, S. Pourteymour, D. Baldassarre, E. Tremoli, F. Veglia, R. Rauramaa, A.J. Smit, P. Giral, S. Kurl, M. Pirro, U. de Faire, S.E. Humphries, A. Hamsten, I. Gonçalves, M. Orho‐Melander, A. Fr
Journal of Internal Medicine.2019; 286(6): 660. CrossRef
PCSK9: A new participant in lipophagy in regulating atherosclerosis?
Jun Xiao, Yi-Min Deng, Xiang-Rui Liu, Jian-Ping Cao, Min Zhou, Ya-Ling Tang, Wen-Hao Xiong, Zhi-Sheng Jiang, Zhi-Han Tang, Lu-Shan Liu
Clinica Chimica Acta.2019; 495: 358. CrossRef
Autophagy-Mediated Cholesterol Trafficking Controls Steroid Production
Michael J. Texada, Alina Malita, Christian F. Christensen, Kathrine B. Dall, Nils J. Faergeman, Stanislav Nagy, Kenneth A. Halberg, Kim Rewitz
Developmental Cell.2019; 48(5): 659. CrossRef
Lipophagy in nonliver tissues and some related diseases: Pathogenic and therapeutic implications
Kebing Zhou, Pingbo Yao, Jun He, Hong Zhao
Journal of Cellular Physiology.2019; 234(6): 7938. CrossRef
Autophagy differentially regulates macrophage lipid handling depending on the lipid substrate (oleic acid vs. acetylated-LDL) and inflammatory activation state
Sapir Hadadi-Bechor, Yulia Haim, Tal Pecht, Roni Gat, Tanya Tarnovscki, Martin Gericke, Assaf Rudich
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(12): 158527. CrossRef
Autophagy and Age-Related Eye Diseases
Xue Yang, Xinan Pan, Xiaorui Zhao, Jin Luo, Mingpu Xu, Daoming Bai, Yan Hu, Xu Liu, Qiongfang Yu, Dian Gao
BioMed Research International.2019; 2019: 1. CrossRef
Foam cell formation and cholesterol trafficking and metabolism disturbances in atherosclerosis
Alexandrina Volobueva, Dongwei Zhang, Andrey V. Grechko, Alexander N. Orekhov
Cor et Vasa.2019; 61(1): 48. CrossRef
Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans
Loredana Bergandi, Oleksii A Skorokhod, Rosalba La Grotta, Evelin Schwarzer, Raffaele Nuzzi
Journal of Ophthalmology.2019; 2019: 1. CrossRef
Programmed cell death protein 4 deficiency suppresses foam cell formation by activating autophagy in advanced glycation end‐product low‐density lipoprotein–induced macrophages
Shan Li, Guangdong Gao, Fuyun Wu, Dan Liu, Hongyan Zhao, Jing Ke, Ying Liu, Fei Li, Jian Li, Zongyun Chen, Zhiming Tang, Lei Bai, Jinxuan Zhang, Wei Zheng, Xin Chen
Journal of Cellular Biochemistry.2019; 120(5): 7689. CrossRef
Mindin deficiency in macrophages protects against foam cell formation and atherosclerosis by targeting LXR-β
Cheng Zhang, Juan-Juan Qin, Fu-Han Gong, Jing-Jing Tong, Wen-Lin Cheng, Haiping Wang, Yan Zhang, Xueyong Zhu, Zhi-Gang She, Hao Xia, Li-Hua Zhu
Clinical Science.2018; 132(11): 1199. CrossRef
LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice
Jong-Gil Park, Se-Jin Jeong, Jinha Yu, Gyudong Kim, Lak Shin Jeong, Goo Taeg Oh
BMB Reports.2018; 51(10): 520. CrossRef
Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis
Dmitry Y. Litvinov, Eugeny V. Savushkin, Alexander D. Dergunov
Journal of Lipids.2018; 2018: 1. CrossRef

Original Articles

Endocrine Research
Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer: Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park; Endocrinol Metab. 2016;31(3):469-475. Published online August 2, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.3.469

8,897 View
58 Download
29 Web of Science
24 Crossref

Abstract PDF PubReader

Background

Tumor associated macrophages (TAMs) and CXC chemokine receptor 4 (CXCR4) have emerged as potential biomarkers in various human cancers. The aims of this study were to investigate the clinical characteristics of anaplastic thyroid cancer (ATC) patients according to the TAM numbers in the tumor tissue, and to evaluate the associations between CXCR4 expressions and macrophage densities in ATC tumor microenvironment.

Methods

Total 14 ATC samples from thyroid tissue microarray were used. Immunohistochemical staining was performed using anti-CD163 and anti-CXCR4 antibodies. According to the immunoreactivity of CD163, all subjects were divided into two groups: low-CD163 (n=8) and high-CD163 (n=6) groups.

Results

The mean diagnostic age was 65±7 years and the median tumor size was 4.3 cm, ranging 2.5 to 15 cm. Clinicopathological characteristics were not significantly different between low-CD163 and high-CD163 groups, while age of diagnosis was younger in high-CD163 group than that of low-CD163 group with marginal significance (56.9±5.5 years vs. 67.5±6.8 years, P=0.09). However, overall survival was significantly reduced in high-CD163 group (5.5 months [range, 1 to 10]) compared with low-CD163 groups (8.8 months [range, 6 to 121); log-rank test, P=0.0443). Moreover, high-CD163 group showed strong CXCR4 expressions in both cancer and stromal compartments, while low-CD163 group showed relatively weak, stromal-dominant CXCR4 expressions. Additionally, CD163 and CXCR4 expressions showed a strong positive correlation (γ²=0.432, P=0.013).

Conclusion

Increased number of TAMs showed poor overall survival in ATC, suggesting TAMs are potentially a prognostic biomarker for ATC. CXCR4 expression was significantly correlated with CD163-positive TAM densities, which suggest the possible role of CXCR4 in TAM recruitments.

Citations

Citations to this article as recorded by

Cancer Stemness and Dedifferentiation in Anaplastic Thyroid Carcinoma: Insights into a Multigenic, Microenvironmental Network and the Role of CD44
Benny Mosoane, Brandon S. Jackson, Michelle McCabe, Tebogo Marutha, Zodwa Dlamini
Biomedicines.2026; 14(2): 453. CrossRef
HN1/CEBPB/CCL2 signaling shapes VSIG4+ tumor-associated macrophages in anaplastic thyroid carcinoma
Ziwen Fang, Ying Li, Xiaoping Hu, Jinming Chen, Zixue Xuan, Shanshan Wang, Rui Zhao, Ruidan Zhang, Yixuan Wang, Ping Huang, Jiafeng Wang, Zongfu Pan
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2026; 1872(7): 168303. CrossRef
Routine Blood Tests as Predictive Tools for Differentiating Follicular Thyroid Carcinoma From Follicular Adenoma
Jiaxi Wang, Jingwei Wang, Hanqing Liu, Chuang Chen
International Journal of General Medicine.2025; Volume 18: 733. CrossRef
Anaplastic thyroid cancer: Genetic roles, targeted therapy, and immunotherapy
Zhao Zou, Linhong Zhong
Genes & Diseases.2025; 12(4): 101403. CrossRef
Turning tumor microenvironmental foes to friends: A new opportunity for thyroid cancer therapy and redifferentiation
Liya Zhu, Xiuli Jing, Byeong-Cheol Ahn
Oral Oncology.2025; 168: 107513. CrossRef
Expression of Sodium Iodide Symporter in Breast Cancer Tissue after Thyroid Cancer
Ye An Kim, Hye Sook Min, Hwa Young Ahn, Young A Kim, Young Joo Park
International Journal of Thyroidology.2025; 18(2): 157. CrossRef
Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy
Naimah Turner, Sarah Hamidi, Rim Ouni, Rene Rico, Ying C. Henderson, Maria Puche, Sayan Alekseev, Jocelynn G. Colunga-Minutti, Mark E. Zafereo, Stephen Y. Lai, Sang T. Kim, Maria E. Cabanillas, Roza Nurieva
Frontiers in Immunology.2024;[Epub] CrossRef
Immune microenvironment in papillary thyroid carcinoma: roles of immune cells and checkpoints in disease progression and therapeutic implications
Xun Zheng, Ruonan Sun, Tao Wei
Frontiers in Immunology.2024;[Epub] CrossRef
IL2RA+VSIG4+ tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer
Zongfu Pan, Lisha Bao, Xixuan Lu, Xiaoping Hu, Lu Li, Jinming Chen, Tiefeng Jin, Yiwen Zhang, Zhuo Tan, Ping Huang, Minghua Ge
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(1): 166591. CrossRef
Crosstalk between Thyroid Carcinoma and Tumor-Correlated Immune Cells in the Tumor Microenvironment
Mingyuan Song, Qi Liu, Wei Sun, Hao Zhang
Cancers.2023; 15(10): 2863. CrossRef
Modeling the tumor microenvironment of anaplastic thyroid cancer: an orthotopic tumor model in C57BL/6 mice
Zhen Xu, Hyo Shik Shin, Yoo Hyung Kim, Seong Yun Ha, Jae-Kyung Won, Su-jin Kim, Young Joo Park, Sareh Parangi, Sun Wook Cho, Kyu Eun Lee
Frontiers in Immunology.2023;[Epub] CrossRef
Tumor-associated macrophages as a potential therapeutic target in thyroid cancers
Liya Zhu, Xiu Juan Li, Prakash Gangadaran, Xiuli Jing, Byeong-Cheol Ahn
Cancer Immunology, Immunotherapy.2023; 72(12): 3895. CrossRef
Functional Phenotypes of Peritoneal Macrophages Upon AMD3100 Treatment During Colitis-Associated Tumorigenesis
Shuai Wu, Weiwei Luo, Xing Wu, Zhaohua Shen, Xiaoyan Wang
Frontiers in Medicine.2022;[Epub] CrossRef
Integrated analysis of novel macrophage related signature in anaplastic thyroid cancer
Yi Luo, Yi-Chen Yang, Ben Ma, Wei-Bo Xu, Tian Liao, Yu Wang
Endocrine.2022; 78(3): 517. CrossRef
Secreted Factors by Anaplastic Thyroid Cancer Cells Induce Tumor-Promoting M2-like Macrophage Polarization through a TIM3-Dependent Mechanism
Cinthia Carolina Stempin, Romina Celeste Geysels, Sunmi Park, Luz Maria Palacios, Ximena Volpini, Claudia Cristina Motran, Eva Virginia Acosta Rodríguez, Juan Pablo Nicola, Sheue-yann Cheng, Claudia Gabriela Pellizas, Laura Fozzatti
Cancers.2021; 13(19): 4821. CrossRef
Immunotherapy for anaplastic thyroid carcinoma: the present and future
Xixuan LU, Lisha BAO, Zongfu PAN, Minghua GE
Journal of Zhejiang University (Medical Sciences).2021; 50(6): 675. CrossRef
CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy
Ashraf Mousavi
Immunology Letters.2020; 217: 91. CrossRef
Nobiletin Alone or in Combination with Cisplatin Decreases the Viability of Anaplastic Thyroid Cancer Cell Lines
Diana P. Sousa, Marta Pojo, Ana T. Pinto, Valeriano Leite, Ana Teresa Serra, Branca M. Cavaco
Nutrition and Cancer.2020; 72(2): 352. CrossRef
The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication
Laura MacDonald, Jonathan Jenkins, Grace Purvis, Joshua Lee, Aime T. Franco
Hormones and Cancer.2020; 11(5-6): 205. CrossRef
Mouse Models as a Tool for Understanding Progression in BrafV600E-Driven Thyroid Cancers
Iñigo Landa, Jeffrey A. Knauf
Endocrinology and Metabolism.2019; 34(1): 11. CrossRef
Low Lymphocyte-to-Monocyte Ratios Are Associated with Poor Overall Survival in Anaplastic Thyroid Carcinoma Patients
Jonghwa Ahn, Eyun Song, Hye-Seon Oh, Dong Eun Song, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Min Ji Jeon
Thyroid®.2019; 29(6): 824. CrossRef
Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy
Christian M. Schürch, Matthias A. Roelli, Stefan Forster, Marie-Hélène Wasmer, Frido Brühl, Renaud S. Maire, Sergio Di Pancrazio, Marc-David Ruepp, Roland Giger, Aurel Perren, Anja M. Schmitt, Philippe Krebs, Roch-Philippe Charles, Matthias S. Dettmer
Thyroid®.2019; 29(7): 979. CrossRef
Recent advances and emerging therapies in anaplastic thyroid carcinoma
Maria E. Cabanillas, Mark Zafereo, Michelle D. Williams, Renata Ferrarotto, Ramona Dadu, Neil Gross, G. Brandon Gunn, Heath Skinner, Gilbert Cote, Horiana B. Grosu, Priyanka Iyer, Naifa L. Busaidy
F1000Research.2018; 7: 87. CrossRef
Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer
Marika H Tesselaar, Johannes W Smit, James Nagarajah, Romana T Netea-Maier, Theo S Plantinga
Journal of Molecular Endocrinology.2017; 59(4): R141. CrossRef

Thyroid
The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma: Seunghwan Kim, Sun Wook Cho, Hye Sook Min, Kang Min Kim, Gye Jeong Yeom, Eun Young Kim, Kyu Eun Lee, Yeo Gyu Yun, Do Joon Park, Young Joo Park; Endocrinol Metab. 2013;28(3):192-198. Published online September 13, 2013; DOI: https://doi.org/10.3803/EnM.2013.28.3.192

10,129 View
54 Download
49 Crossref

Abstract PDF PubReader

Background

Tumor-associated macrophages (TAMs) play a tumorigenic role related to advanced staging and poor prognosis in many human cancers including thyroid cancers. Yet, a functional role of TAMs in papillary thyroid carcinoma (PTC) has not been established. The aim of this study was to investigate TAM expression in human PTC with lymph node (LN) metastasis.

Methods

Thirty-six patients who underwent surgery after being diagnosed with PTC with LN metastasis were included. Primary tumor tissues were immunohistochemically stained with an anti-CD68 antibody and clinical characteristics according to TAM density were evaluated.

Results

The TAM densities (CD68⁺ cells) varied from 5% to 70%, in all tumor areas, while few cells were stained in adjacent normal tissues. TAMs were identified as CD68⁺ cells with thin, elongated cytoplasmic extensions that formed a canopy structure over tumor cells. Comparing clinicopathologic characteristics between tumors with low (<25%) and high (25% to 70%) TAM densities, primary tumors were larger in the high density group than in the low density group (2.0±0.1 vs. 1.5±0.1; P=0.009).

Conclusion

TAMs were identified in primary PTC tumors with LN metastasis and higher TAM densities were related to larger tumor sizes, suggesting a tumorigenic role of TAMs in human PTCs.

Citations

Citations to this article as recorded by

Single-cell sequencing reveals the tumor immune microenvironment in thyroid cancer: a narrow review
Kangcong Liang, Ziyu Wang, Zhiqiang Zhang, Gengluan Liu, Xidi Wang, Heng Cao, Ming Zhong, Liping Ye, Xin Zhong, Jingyu Xun, Kefeng Lei, Ningning Li
Frontiers in Immunology.2026;[Epub] CrossRef
TIM3 as a therapeutic target in anaplastic thyroid cancer: upregulation in M2‐like macrophages induced by tumor microenvironment‐derived TGFβ1
Agustina Jaroszewski, Yeon‐Sook Choi, Florencia Hellriegel, Wei Zhang, Fernando Carrizo, Dong Eun Song, María Victoria Laborie, Marcelo Ruggieri, Emiliano Peretti, María Victoria Banus, Cinthia Carolina Stempin, Juan Pablo Nicola, Eva Virginia Acosta Rodr
The Journal of Pathology.2026;[Epub] CrossRef
Exploring the role of immunotherapy in the management of follicular cell-derived thyroid cancer
Paige Benson, Omar Abdel-Rahman
Immunotherapy.2025; 17(1): 47. CrossRef
Macrophage abundance in oncocytic thyroid cancer is associated with PD-L1 expression
Julio C Ricarte-Filho, Caitlin O Caperton, Amber Isaza, Nicole A Massoll, Aime T Franco
Endocrine Oncology.2025;[Epub] CrossRef
Single-cell RNA-seq reveals MIF−(CD74 + CXCR4) dependent inhibition of macrophages in metastatic papillary thyroid carcinoma
Wei Chen, Xinnian Yu, Huixin Li, Shenglong Yuan, Yuqi Fu, Huanhuan Hu, Fangzhou Liu, Yuan Zhang, Shanliang Zhong
Oral Oncology.2024; 148: 106654. CrossRef
Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy
Naimah Turner, Sarah Hamidi, Rim Ouni, Rene Rico, Ying C. Henderson, Maria Puche, Sayan Alekseev, Jocelynn G. Colunga-Minutti, Mark E. Zafereo, Stephen Y. Lai, Sang T. Kim, Maria E. Cabanillas, Roza Nurieva
Frontiers in Immunology.2024;[Epub] CrossRef
Thyroid Gland Diffuse Lipomatosis: A Case Study and Comprehensive Literature Review
Angeliki Emmanouilidou, Michail Karanikas, Kalliopi Pazaitou-Panayiotou, Nickos Michalopoulos
Journal of Clinical Medicine.2024; 13(21): 6376. CrossRef
H2AFX might be a prognostic biomarker for hepatocellular carcinoma
Hailiang Hu, Tao Zhong, Suwei Jiang
Cancer Reports.2023;[Epub] CrossRef
The Tumor Microenvironment and the Estrogen Loop in Thyroid Cancer
Nerina Denaro, Rebecca Romanò, Salvatore Alfieri, Alessia Dolci, Lisa Licitra, Imperia Nuzzolese, Michele Ghidini, Claudia Bareggi, Valentina Bertaglia, Cinzia Solinas, Ornella Garrone
Cancers.2023; 15(9): 2458. CrossRef
New Insights into Immune Cells and Immunotherapy for Thyroid Cancer
Yujia Tao, Peng Li, Chao Feng, Yuan Cao
Immunological Investigations.2023; 52(8): 1039. CrossRef
Roles and new Insights of Macrophages in the Tumor Microenvironment of Thyroid Cancer
Qi Liu, Wei Sun, Hao Zhang
Frontiers in Pharmacology.2022;[Epub] CrossRef
Construction of a Tumor Immune Microenvironment-Related Prognostic Model in BRAF-Mutated Papillary Thyroid Cancer
Yuxiao Xia, Xue Jiang, Yuan Huang, Qian Liu, Yin Huang, Bo Zhang, Zhanjun Mei, Dongkun Xu, Yuhong Shi, Wenling Tu
Frontiers in Endocrinology.2022;[Epub] CrossRef
Identification and Validation of Prognostic Related Hallmark ATP-Binding Cassette Transporters Associated With Immune Cell Infiltration Patterns in Thyroid Carcinoma
Lidong Wang, Xiaodan Sun, Jingni He, Zhen Liu
Frontiers in Oncology.2022;[Epub] CrossRef
Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma
Alessandra di Masi, Rosario Luigi Sessa, Ylenia Cerrato, Gianni Pastore, Barbara Guantario, Roberto Ambra, Michael Di Gioacchino, Armida Sodo, Martina Verri, Pierfilippo Crucitti, Filippo Longo, Anda Mihaela Naciu, Andrea Palermo, Chiara Taffon, Filippo A
Antioxidants.2022; 11(8): 1463. CrossRef
What is the status of immunotherapy in thyroid neoplasms?
Alejandro Garcia-Alvarez, Jorge Hernando, Ana Carmona-Alonso, Jaume Capdevila
Frontiers in Endocrinology.2022;[Epub] CrossRef
Matrix Metalloproteinase 9 Expression by Immunohistochemistry in Intratumor Macrophages as Tumor-Associated Macrophage Marker of Papillary Thyroid Carcinoma
Ni Wayan Armerinayanti, Samuel Widodo, Desak Putu Oki Lestari
Biomedical and Pharmacology Journal.2022; 15(3): 1671. CrossRef
Cell Component and Function of Tumor Microenvironment in Thyroid Cancer
Eunah Shin, Ja Seung Koo
International Journal of Molecular Sciences.2022; 23(20): 12578. CrossRef
Potential diagnostic of lymph node metastasis and prognostic values of TM4SFs in papillary thyroid carcinoma patients
Kun Wang, Haomin Li, Junyu Zhao, Jinming Yao, Yiran Lu, Jianjun Dong, Jie Bai, Lin Liao
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef
Thyroid Cancer Stem-Like Cells: From Microenvironmental Niches to Therapeutic Strategies
Elisa Stellaria Grassi, Viola Ghiandai, Luca Persani
Journal of Clinical Medicine.2021; 10(7): 1455. CrossRef
Immune Landscape of Thyroid Cancers: New Insights
Elisa Menicali, Martina Guzzetti, Silvia Morelli, Sonia Moretti, Efisio Puxeddu
Frontiers in Endocrinology.2021;[Epub] CrossRef
FOXE1-Dependent Regulation of Macrophage Chemotaxis by Thyroid Cells In Vitro and In Vivo
Sara Credendino, Marta De Menna, Irene Cantone, Carmen Moccia, Matteo Esposito, Luigi Di Guida, Mario De Felice, Gabriella De Vita
International Journal of Molecular Sciences.2021; 22(14): 7666. CrossRef
Senescent Thyrocytes, Similarly to Thyroid Tumor Cells, Elicit M2-like Macrophage Polarization In Vivo
Mara Mazzoni, Giuseppe Mauro, Lucia Minoli, Loredana Cleris, Maria Chiara Anania, Tiziana Di Marco, Emanuela Minna, Sonia Pagliardini, Maria Grazia Rizzetti, Giacomo Manenti, Maria Grazia Borrello, Eugenio Scanziani, Angela Greco
Biology.2021; 10(10): 985. CrossRef
Characterization of the Immune Cell Infiltration Landscape of Thyroid Cancer for Improved Immunotherapy
Jing Gong, Bo Jin, Liang Shang, Ning Liu
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef
The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication
Laura MacDonald, Jonathan Jenkins, Grace Purvis, Joshua Lee, Aime T. Franco
Hormones and Cancer.2020; 11(5-6): 205. CrossRef
Cancer Stem Cells in Thyroid Tumors: From the Origin to Metastasis
Veronica Veschi, Francesco Verona, Melania Lo Iacono, Caterina D'Accardo, Gaetana Porcelli, Alice Turdo, Miriam Gaggianesi, Stefano Forte, Dario Giuffrida, Lorenzo Memeo, Matilde Todaro
Frontiers in Endocrinology.2020;[Epub] CrossRef
The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition
Gilda Varricchi, Stefania Loffredo, Giancarlo Marone, Luca Modestino, Poupak Fallahi, Silvia Martina Ferrari, Amato de Paulis, Alessandro Antonelli, Maria Rosaria Galdiero
International Journal of Molecular Sciences.2019; 20(16): 3934. CrossRef
Impact of tumor‐associated macrophages and BRAFV600E mutation on clinical outcomes in patients with various thyroid cancers
Jae Won Cho, Won Woong Kim, Yu‐mi Lee, Min Ji Jeon, Won Gu Kim, Dong Eun Song, Yangsoon Park, Ki‐Wook Chung, Suck Joon Hong, Tae‐Yon Sung
Head & Neck.2019; 41(3): 686. CrossRef
Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism
Mara Mazzoni, Giuseppe Mauro, Marco Erreni, Paola Romeo, Emanuela Minna, Maria Grazia Vizioli, Cristina Belgiovine, Maria Grazia Rizzetti, Sonia Pagliardini, Roberta Avigni, Maria Chiara Anania, Paola Allavena, Maria Grazia Borrello, Angela Greco
Journal of Experimental & Clinical Cancer Research.2019;[Epub] CrossRef
Immune and Inflammatory Cells in Thyroid Cancer Microenvironment
Silvia Martina Ferrari, Poupak Fallahi, Maria Rosaria Galdiero, Ilaria Ruffilli, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Armando Patrizio, Valeria Mazzi, Gilda Varricchi, Gianni Marone, Alessandro Antonelli
International Journal of Molecular Sciences.2019; 20(18): 4413. CrossRef
Aberrant Thyroid-Stimulating Hormone Receptor Signaling Increases VEGF-A and CXCL8 Secretion of Thyroid Cancer Cells, Contributing to Angiogenesis and Tumor Growth
Young Shin Song, Min Joo Kim, Hyun Jin Sun, Hwan Hee Kim, Hyo Shik Shin, Young A. Kim, Byung-Chul Oh, Sun Wook Cho, Young Joo Park
Clinical Cancer Research.2019; 25(1): 414. CrossRef
The number of CD163 positive macrophages is associatedwith more advanced skin melanomas, microvessels density and patient prognosis
Maciej Foks, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz, Marta Bonczysta, Bogusław Olborski, Olga Stasikowska-Kanicka
Polish Journal of Pathology.2019; 70(3): 217. CrossRef
Novel targeted therapies and immunotherapy for advanced thyroid cancers
George E. Naoum, Michael Morkos, Brian Kim, Waleed Arafat
Molecular Cancer.2018;[Epub] CrossRef
Potential involvement of neutrophils in human thyroid cancer
Maria Rosaria Galdiero, Gilda Varricchi, Stefania Loffredo, Claudio Bellevicine, Tiziana Lansione, Anne Lise Ferrara, Raffaella Iannone, Sarah di Somma, Francesco Borriello, Eduardo Clery, Maria Triassi, Giancarlo Troncone, Gianni Marone, Fabrizio Mattei
PLOS ONE.2018; 13(6): e0199740. CrossRef
Bleomycin inhibits proliferation and induces apoptosis in TPC‑1 cells through reversing M2‑macrophages polarization
Hongwei Liu, Huilei Dong, Li Jiang, Zhendong Li, Xiande Ma
Oncology Letters.2018;[Epub] CrossRef
Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer
Marika H Tesselaar, Johannes W Smit, James Nagarajah, Romana T Netea-Maier, Theo S Plantinga
Journal of Molecular Endocrinology.2017; 59(4): R141. CrossRef
Association of infiltrating cells with microvessel density in oral squamous cell carcinoma
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
Polish Journal of Pathology.2017; 68(1): 40. CrossRef
Histological perspective on the effects of tumor-associated macrophages in the tumor microenvironment surrounding papillary thyroid carcinoma
Nuray Y. Can, Semra Ayturk, Mehmet Celik, Yavuz A. Sezer, Filiz Ozyilmaz, Ebru Tastekin, Necdet Sut, Funda Ustun, Buket Yilmaz Bulbul, Fulya O. Puyan, Sibel Guldiken
Polish Journal of Pathology.2017; 67(4): 332. CrossRef
The immune network in thyroid cancer
Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone
OncoImmunology.2016; 5(6): e1168556. CrossRef
Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
Endocrinology and Metabolism.2016; 31(3): 469. CrossRef
CXCL16 signaling mediated macrophage effects on tumor invasion of papillary thyroid carcinoma
Sun Wook Cho, Young A Kim, Hyun Jin Sun, Ye An Kim, Byung-Chul Oh, Ka Hee Yi, Do Joon Park, Young Joo Park
Endocrine-Related Cancer.2016; 23(2): 113. CrossRef
Role of pulmonary macrophages in initiation of lung metastasis in anaplastic thyroid cancer
Xiu Juan Li, Prakash Gangadaran, Senthilkumar Kalimuthu, Ji Min Oh, Liya Zhu, Shin Young Jeong, Sang‐Woo Lee, Jaetae Lee, Byeong‐Cheol Ahn
International Journal of Cancer.2016; 139(11): 2583. CrossRef
The Expression and Relationship of CD68-Tumor-Associated Macrophages and Microvascular Density With the Prognosis of Patients With Laryngeal Squamous Cell Carcinoma
Shujun Sun, Xinliang Pan, Limin Zhao, Jianming Zhou, Hongzeng Wang, Yonghong Sun
Clinical and Experimental Otorhinolaryngology.2016; 9(3): 270. CrossRef
Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates
Kyong Yeun Jung, Sun Wook Cho, Young A Kim, Daein Kim, Byung-Chul Oh, Do Joon Park, Young Joo Park
Journal of Pathology and Translational Medicine.2015; 49(4): 318. CrossRef
Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer
Sang Mi Kim, Eun Heui Kim, Bo Hyun Kim, Jong Ho Kim, Su Bin Park, Yoon Jeong Nam, Kang Hee Ahn, Min Young Oh, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Ju Kim
Endocrinology and Metabolism.2015; 30(4): 494. CrossRef
Quantitative Changes in Tumor-Associated M2 Macrophages Characterize Cholangiocarcinoma and their Association with Metastasis
Malinee Thanee, Watcharin Loilome, Anchalee Techasen, Nisana Namwat, Thidarut Boonmars, Chawalit Pairojkul, Puangrat Yongvanit
Asian Pacific Journal of Cancer Prevention.2015; 16(7): 3043. CrossRef
Tumor-Associated Macrophage (TAM) and Angiogenesis in Human Colon Carcinoma
Manal A. Badawi, Dalia M. Abouelfadl, Sonia L. El-Sharkawy, Wafaa E. Abd El-Aal, Naglaa F. Abbas
Open Access Macedonian Journal of Medical Sciences.2015; 3(2): 209. CrossRef
Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee
Endocrinology and Metabolism.2014; 29(3): 251. CrossRef
miRNA Expression in Anaplastic Thyroid Carcinomas
Aline Hébrant, Sébastien Floor, Manuel Saiselet, Aline Antoniou, Alice Desbuleux, Bérengère Snyers, Caroline La, Nicolas de Saint Aubain, Emmanuelle Leteurtre, Guy Andry, Carine Maenhaut, Raul M. Luque
PLoS ONE.2014; 9(8): e103871. CrossRef
The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma
Bo Hyun Kim
Endocrinology and Metabolism.2013; 28(3): 178. CrossRef

First
Prev
Page of 1
Next
Last

Search