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Diabetes, Obesity and Metabolism
Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research
Ji-Hoon Kim, Seung-Min Yu, Jang Won Son
Endocrinol Metab. 2022;37(3):408-414.   Published online June 29, 2022
DOI: https://doi.org/10.3803/EnM.2022.302
  • 4,405 View
  • 168 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   
Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle and other metabolic organs in terms of systemic energy homeostasis. This conceptual basis of skeletal muscle as a metabolically active organ has provided insights into the potential role of physical inactivity and conditions altering muscle quality and quantity in the development of multiple metabolic disorders, including insulin resistance, obesity, and diabetes. Therefore, it is important to understand human muscle physiology more deeply in relation to the pathophysiology of metabolic diseases. Since monolayer cell lines or animal models used in conventional research differ from the pathophysiological features of the human body, there is increasing need for more physiologically relevant in vitro models of human skeletal muscle. Here, we introduce recent studies on in vitro models of human skeletal muscle generated from adult myogenic progenitors or pluripotent stem cells and summarize recent progress in the development of three-dimensional (3D) bioartificial muscle, which mimics the physiological complexity of native skeletal muscle tissue in terms of maturation and functionality. We then discuss the future of skeletal muscle 3D-organoid culture technology in the field of metabolic research for studying pathological mechanisms and developing personalized therapeutic strategies.

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  • Human‐based new approach methodologies to accelerate advances in nutrition research
    Manuela Cassotta, Danila Cianciosi, Maria Elexpuru‐Zabaleta, Inaki Elio Pascual, Sandra Sumalla Cano, Francesca Giampieri, Maurizio Battino
    Food Frontiers.2024; 5(3): 1031.     CrossRef
  • Key indicators of beef safety and quality as important aspects of conservation
    S. V. Furman, I. M. Sokulskyi, D. V. Lisohurska, O. V. Lisohurska, B. V. Gutyj
    Ukrainian Journal of Veterinary and Agricultural Sciences.2024; 7(1): 68.     CrossRef
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Miscellaneous
Quality Matters as Much as Quantity of Skeletal Muscle: Clinical Implications of Myosteatosis in Cardiometabolic Health
Hong-Kyu Kim, Chul-Hee Kim
Endocrinol Metab. 2021;36(6):1161-1174.   Published online December 28, 2021
DOI: https://doi.org/10.3803/EnM.2021.1348
  • 6,952 View
  • 307 Download
  • 29 Web of Science
  • 33 Crossref
AbstractAbstract PDFPubReader   ePub   
Although age-related changes in skeletal muscles are closely associated with decreases in muscle strength and functional decline, their associations with cardiometabolic diseases in the literature are inconsistent. Such inconsistency could be explained by the fact that muscle quality—which is closely associated with fatty infiltration of the muscle (i.e., myosteatosis)—is as important as muscle quantity in cardiometabolic health. However, muscle quality has been less explored compared with muscle mass. Moreover, the standard definition of myosteatosis and its assessment methods have not been established yet. Recently, some techniques using single axial computed tomography (CT) images have been introduced and utilized in many studies, as the mass and quality of abdominal muscles could be measured opportunistically on abdominal CT scans obtained during routine clinical care. Yet, the mechanisms by which myosteatosis affect metabolic and cardiovascular health remain largely unknown. In this review, we explore the recent advances in the assessment of myosteatosis and its changes associated with aging. We also review the recent literature on the clinical implication of myosteatosis by focusing on metabolic and cardiovascular diseases. Finally, we discuss the challenges and unanswered questions that need addressing to set myosteatosis as a therapeutic target for the prevention or treatment of cardiometabolic diseases.

Citations

Citations to this article as recorded by  
  • A CT-based Deep Learning Model for Predicting Subsequent Fracture Risk in Patients with Hip Fracture
    Yisak Kim, Young-Gon Kim, Jung-Wee Park, Byung Woo Kim, Youmin Shin, Sung Hye Kong, Jung Hee Kim, Young-Kyun Lee, Sang Wan Kim, Chan Soo Shin
    Radiology.2024;[Epub]     CrossRef
  • Myosteatosis is associated with poor survival after kidney transplantation: a large retrospective cohort validation
    Jie Chen, Yue Li, Chengjie Li, Turun Song
    Abdominal Radiology.2024; 49(4): 1210.     CrossRef
  • Fatty infiltration of gastrocnemius–soleus muscle complex: Considerations for myosteatosis rehabilitation
    Catherine Hatzantonis, Lalith Satkunam, Karyne N. Rabey, Jennifer C. Hocking, Anne M. R. Agur
    Journal of Anatomy.2024; 245(1): 50.     CrossRef
  • Muscle attenuation, not skeletal muscle index, is an independent prognostic factor for survival in gastric cancer patients with overweight and obesity
    Cheng-Le Zhuang, Hao-Fan Wu, Hao-Jie Jiang, Feng-Min Zhang, Han-Ping Shi, Zhen Yu, Xian Shen, Xiao-Lei Chen, Su-Lin Wang
    Nutrition.2024; 122: 112391.     CrossRef
  • Myosteatosis is associated with coronary artery calcification in patients with type 2 diabetes
    Fu-Peng Liu, Mu-Jie Guo, Qing Yang, Yan-Ying Li, Yan-Gang Wang, Mei Zhang
    World Journal of Diabetes.2024; 15(3): 429.     CrossRef
  • Unlocking liver health: Can tackling myosteatosis spark remission in metabolic dysfunction‐associated steatotic liver disease?
    Guillaume Henin, Audrey Loumaye, Louise Deldicque, Isabelle A. Leclercq, Nicolas Lanthier
    Liver International.2024;[Epub]     CrossRef
  • Skeletal muscle mass obtained by anthropometric equation and presence of sarcopenia in postmenopausal women
    Thaís Loureiro Felipe, Patrícia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Ben-Hur Albergaria, Geise Ferreira da Cruz, José Luiz Marques-Rocha, Valdete Regina Guandalini
    Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics.2024;[Epub]     CrossRef
  • Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies
    Kylie Heitman, Matthew S. Alexander, Christian Faul
    International Journal of Molecular Sciences.2024; 25(10): 5117.     CrossRef
  • Myosteatosis and not low muscle mass is associated with lower survival in kidney transplant recipients
    Kristoffer N.D. Huitfeldt Sola, Helena M. Genberg, Carla M. Avesani, Torkel B. Brismar
    JCSM Communications.2024;[Epub]     CrossRef
  • Association of serum gamma-glutamyl transferase with myosteatosis assessed by muscle quality mapping using abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Joong-Yeol Park, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Clinical Imaging.2023; 93: 4.     CrossRef
  • Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
    Shi Zhang, Yaping Huang, Jing Li, Xincheng Wang, Xiaohe Wang, Minying Zhang, Yanju Zhang, Meiyang Du, Jingna Lin, Chunjun Li
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • Association between hypertension and myosteatosis evaluated by abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Hypertension Research.2023; 46(4): 845.     CrossRef
  • Epidemiological, mechanistic, and practical bases for assessment of cardiorespiratory fitness and muscle status in adults in healthcare settings
    Jaime A. Gallo-Villegas, Juan C. Calderón
    European Journal of Applied Physiology.2023; 123(5): 945.     CrossRef
  • Muscle fat infiltration in chronic kidney disease: a marker related to muscle quality, muscle strength and sarcopenia
    Carla Maria Avesani, Aline Miroski de Abreu, Heitor S. Ribeiro, Torkel B. Brismar, Peter Stenvinkel, Alice Sabatino, Bengt Lindholm
    Journal of Nephrology.2023; 36(3): 895.     CrossRef
  • IDF2022-1139 Association Between Dyslipidemia And Myosteatosis Using Visual Muscular Quality Map In Computed Tomography
    H.S. Kim, H.N. Jung, Y.K. Cho, E.H. Kim, M.J. Lee, W.J. Lee, J.Y. Park, H.K. Kim, C.H. Jung
    Diabetes Research and Clinical Practice.2023; 197: 110467.     CrossRef
  • The role of skeletal muscle mass on cardiovascular disease risk: an emerging role on modulating lipid profile
    Evangelia Damigou, Matina Kouvari, Demosthenes Panagiotakos
    Current Opinion in Cardiology.2023; 38(4): 352.     CrossRef
  • Reference values for low muscle mass and myosteatosis using tomographic muscle measurements in living kidney donors
    Lisa B. Westenberg, Marcel Zorgdrager, Tim D. A. Swaab, Marco van Londen, Stephan J. L. Bakker, Henri G. D. Leuvenink, Alain R. Viddeleer, Robert A. Pol
    Scientific Reports.2023;[Epub]     CrossRef
  • Association between sarcopenic obesity and poor muscle quality based on muscle quality map and abdominal computed tomography
    Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Joong‐Yeol Park, Woo Je Lee, Hong‐Kyu Kim, Chang Hee Jung
    Obesity.2023; 31(6): 1547.     CrossRef
  • Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
    Caterina Rosano, Anne Newman, Adam Santanasto, Xiaonan Zhu, Bret Goodpaster, Iva Miljkovic
    Journal of the American Geriatrics Society.2023; 71(9): 2759.     CrossRef
  • Evaluation of Paraspinal Muscle Degeneration on Pain Relief after Percutaneous Epidural Adhesiolysis in Patients with Degenerative Lumbar Spinal Disease
    Misun Kang, Shin Hyung Kim, Minju Jo, Hyun Eom Jung, Jungbin Bae, Hee Jung Kim
    Medicina.2023; 59(6): 1118.     CrossRef
  • Sarcopenic obesity and its relation with muscle quality and mortality in patients on chronic hemodialysis
    Alice Sabatino, Carla Maria Avesani, Giuseppe Regolisti, Marianna Adinolfi, Giuseppe Benigno, Marco Delsante, Enrico Fiaccadori, Ilaria Gandolfini
    Clinical Nutrition.2023; 42(8): 1359.     CrossRef
  • Association between computed tomography‐assessed sarcopenia and mortality in patients with anti‐neutrophil cytoplasmic antibody‐associated vasculitis
    Sung Soo Ahn, Yong‐Beom Park, Sang‐Won Lee
    International Journal of Rheumatic Diseases.2023; 26(9): 1704.     CrossRef
  • Association Between Insulin Resistance and Myosteatosis Measured by Abdominal Computed Tomography
    Myung Jin Kim, Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(12): 3100.     CrossRef
  • Association of Visceral Fat Obesity, Sarcopenia, and Myosteatosis with Non-Alcoholic Fatty Liver Disease without Obesity
    Hong-Kyu Kim, Sung-Jin Bae, Min Jung Lee, Eun Hee Kim, Hana Park, Hwi Seung Kim, Yun Kyung Cho, Chang Hee Jung, Woo Je Lee, Jaewon Choe
    Clinical and Molecular Hepatology.2023; 29(4): 987.     CrossRef
  • Different computed tomography parameters for defining myosteatosis in patients with advanced non-small cell lung cancer
    Wenyi Zhang, Jing Tang, Huiyu Tang, Lingling Xie, Jing Wang, Jinhui Wu, Ming Yang
    Clinical Nutrition.2023; 42(12): 2414.     CrossRef
  • All you need to know about sarcopenia: a short guide for an internal medicine physician in questions and answers
    G. R. Bikbavova, M. A. Livzan, D. V. Tikhonravova
    Bulletin of Siberian Medicine.2023; 22(3): 88.     CrossRef
  • Muscle Fat Content Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis in Chinese Adults
    W. Guo, X. Zhao, D. Cheng, X. Liang, M. Miao, X. Li, J. Lu, N. Xu, Shuang Hu, Qun Zhang
    The Journal of nutrition, health and aging.2023; 27(11): 960.     CrossRef
  • Body Composition Evaluation and Clinical Markers of Cardiometabolic Risk in Patients with Phenylketonuria
    Luis M. Luengo-Pérez, Mercedes Fernández-Bueso, Ana Ambrojo, Marta Guijarro, Ana Cristina Ferreira, Luís Pereira-da-Silva, André Moreira-Rosário, Ana Faria, Conceição Calhau, Anne Daly, Anita MacDonald, Júlio César Rocha
    Nutrients.2023; 15(24): 5133.     CrossRef
  • Information of Vertebral Bone and Muscle from Computed Tomography Imaging Improves the Prediction Power of Vertebral Fractures Using Deep-Learning Algorithm (Preprint)
    Sung Hye Kong, Wonwoo Cho, Sung Bae Park, Jaegul Choo, Jung Hee Kim, Sang Wan Kim, Chan Soo Shin
    Journal of Medical Internet Research.2023;[Epub]     CrossRef
  • Assessment of Muscle Quantity, Quality and Function
    Bo Kyung Koo
    Journal of Obesity & Metabolic Syndrome.2022; 31(1): 9.     CrossRef
  • Influence of cross‐sectional area and fat infiltration of paraspinal muscles on analgesic efficacy of epidural steroid injection in elderly patients
    Hee Jung Kim, Miribi Rho, Kyung Bong Yoon, Minju Jo, Dong Woo Lee, Shin Hyung Kim
    Pain Practice.2022; 22(7): 621.     CrossRef
  • Sarcopenia, Obesity, Sarcopenic Obesity and Risk of Poor Nutritional Status in Polish Community-Dwelling Older People Aged 60 Years and Over
    Marika Murawiak, Roma Krzymińska-Siemaszko, Aleksandra Kaluźniak-Szymanowska, Marta Lewandowicz, Sławomir Tobis, Katarzyna Wieczorowska-Tobis, Ewa Deskur-Śmielecka
    Nutrients.2022; 14(14): 2889.     CrossRef
  • Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation
    Amedeo Lonardo, Alessandro Mantovani, Salvatore Petta, Amedeo Carraro, Christopher D. Byrne, Giovanni Targher
    Nature Reviews Endocrinology.2022; 18(10): 638.     CrossRef
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Diabetes, Obesity and Metabolism
Exercise/Resistance Training and Muscle Stem Cells
So-ichiro Fukada, Ayasa Nakamura
Endocrinol Metab. 2021;36(4):737-744.   Published online August 10, 2021
DOI: https://doi.org/10.3803/EnM.2021.401
  • 5,635 View
  • 263 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   ePub   
Skeletal muscle has attracted attention as endocrine organ, because exercise-dependent cytokines called myokines/exerkines are released from skeletal muscle and are involved in systemic functions. While, local mechanical loading to skeletal muscle by exercise or resistance training alters myofiber type and size and myonuclear number. Skeletal muscle-resident stem cells, known as muscle satellite cells (MuSCs), are responsible for the increased number of myonuclei. Under steady conditions, MuSCs are maintained in a mitotically quiescent state but exit from that state and start to proliferate in response to high physical activity. Alterations in MuSC behavior occur when myofibers are damaged, but the lethal damage to myofibers does not seem to evoke mechanical loading-dependent MuSC activation and proliferation. Given that MuSCs proliferate without damage, it is unclear how the different behaviors of MuSCs are controlled by different physical activities. Recent studies demonstrated that myonuclear number reflects the size of myofibers; hence, it is crucial to know the properties of MuSCs and the mechanism of myonuclear accretion by MuSCs. In addition, the elucidation of mechanical load-dependent changes in muscle resident cells, including MuSCs, will be necessary for the discovery of new myokines/exerkines and understating skeletal muscle diseases.

Citations

Citations to this article as recorded by  
  • Control of muscle satellite cell function by specific exercise‐induced cytokines and their applications in muscle maintenance
    Qian Guo, Qing Luo, Guanbin Song
    Journal of Cachexia, Sarcopenia and Muscle.2024; 15(2): 466.     CrossRef
  • Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice
    Yating Huang, Chenxin Jiang, Xiuru Li, Sujuan Liu, Yanmei Niu, Li Fu
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(4): 167111.     CrossRef
  • Anthropometric, muscle and serum myokine levels effects of physical exercise with an online platform in female patients with obesity
    David Primo, Olatz Izaola, Juan Jose Lopez Gomez, Daniel de Luis
    Endocrinología, Diabetes y Nutrición.2023; 70(7): 484.     CrossRef
  • Anthropometric, muscle and serum myokine levels effects of physical exercise with an online platform in female patients with obesity
    David Primo, Olatz Izaola, Juan Jose Lopez Gomez, Daniel de Luis
    Endocrinología, Diabetes y Nutrición (English ed.).2023; 70(7): 484.     CrossRef
  • The muscle stem cell niche at a glance
    Margaret Hung, Hsiao-Fan Lo, Grace E. L. Jones, Robert S. Krauss
    Journal of Cell Science.2023;[Epub]     CrossRef
  • Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors
    Hamed Alizadeh Pahlavani
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Molecular mechanisms of exercise contributing to tissue regeneration
    Jibao Chen, Ren Zhou, Ye Feng, Lin Cheng
    Signal Transduction and Targeted Therapy.2022;[Epub]     CrossRef
Close layer
Diabetes, Obesity and Metabolism
Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics
Jong Hyeon Yoon, Ki-Sun Kwon
Endocrinol Metab. 2021;36(3):478-490.   Published online June 28, 2021
DOI: https://doi.org/10.3803/EnM.2021.1081
  • 9,252 View
  • 346 Download
  • 9 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   ePub   
Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways. Therefore, signaling receptors are major targets in pharmacological strategies in general. To provide a rationale for pharmacological interventions for sarcopenia, we herein describe several druggable signaling receptors based on their role in skeletal muscle homeostasis and changes in their activity with aging. A brief overview is presented of the efficacy of corresponding drug candidates under clinical trials. Strategies targeting the androgen receptor, vitamin D receptor, Insulin-like growth factor-1 receptor, and ghrelin receptor primarily focus on promoting anabolic action using natural ligands or mimetics. Strategies involving activin receptors and angiotensin receptors focus on inhibiting catabolic action. This review may help to select specific targets or combinations of targets in the future.

Citations

Citations to this article as recorded by  
  • The Current Landscape of Pharmacotherapies for Sarcopenia
    Gulistan Bahat, Serdar Ozkok
    Drugs & Aging.2024; 41(2): 83.     CrossRef
  • Associations of micronutrient dietary patterns with sarcopenia among US adults: a population-based study
    Yining Liu, Xiangliang Liu, Linnan Duan, Yixin Zhao, Yuwei He, Wei Li, Jiuwei Cui
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Impact of Vitamin D Level on Sarcopenia in Elderly People: A Critical Review
    Saniya Khan, Sunil Kumar, Sourya Acharya, Anil Wanjari
    Journal of Health and Allied Sciences NU.2023; 13(04): 453.     CrossRef
  • Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A
    Waly Dioh, Vihang Narkar, Anurag Singh, Fady Malik, Luigi Ferrucci, Cendrine Tourette, Jean Mariani, Rob van Maanen, Roger A Fielding, Lewis A Lipsitz
    The Journals of Gerontology: Series A.2023; 78(Supplement): 44.     CrossRef
  • Alverine citrate promotes myogenic differentiation and ameliorates muscle atrophy
    Jong Hyeon Yoon, Seung-Min Lee, Younglang Lee, Min Ju Kim, Jae Won Yang, Jeong Yi Choi, Ju Yeon Kwak, Kwang-Pyo Lee, Yong Ryoul Yang, Ki-Sun Kwon
    Biochemical and Biophysical Research Communications.2022; 586: 157.     CrossRef
  • Adeno-associated virus-mediated expression of an inactive CaMKIIβ mutant enhances muscle mass and strength in mice
    Takahiro Eguchi, Yuji Yamanashi
    Biochemical and Biophysical Research Communications.2022; 589: 192.     CrossRef
  • Gastric Mobility and Gastrointestinal Hormones in Older Patients with Sarcopenia
    Hsien-Hao Huang, Tse-Yao Wang, Shan-Fan Yao, Pei-Ying Lin, Julia Chia-Yu Chang, Li-Ning Peng, Liang-Kung Chen, David Hung-Tsang Yen
    Nutrients.2022; 14(9): 1897.     CrossRef
  • Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia
    Marcela Kanova, Pavel Kohout
    International Journal of Molecular Sciences.2022; 23(15): 8396.     CrossRef
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Original Article
Diabetes, Obesity and Metabolism
Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population
Ja Kyung Yoon, Sunyoung Lee, Kyoung Won Kim, Ji Eun Lee, Jeong Ah Hwang, Taeyong Park, Jeongjin Lee
Endocrinol Metab. 2021;36(3):672-677.   Published online June 8, 2021
DOI: https://doi.org/10.3803/EnM.2021.1041
  • 4,584 View
  • 161 Download
  • 13 Web of Science
  • 11 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
Sarcopenia is defined as the loss of skeletal muscle mass and is associated with negative clinical outcomes. This study aimed to establish sex-specific cutoff values for the skeletal muscle area (SMA) and skeletal muscle index (SMI) at the third lumbar vertebral (L3) level using computed tomography (CT) imaging to identify sarcopenia in healthy Korean liver donors.
Methods
This retrospective study included 659 healthy liver donors (408 men and 251 women) aged 20 to 60 years who had undergone abdominal CT examinations between January 2017 and December 2018. Assessment of body composition was performed with an automated segmentation technique using a deep-learning system. Sex-specific SMA and SMI distributions were assessed, and cutoff values for determining sarcopenia were defined as values at either two standard deviations (SDs) below the mean reference value or below the fifth percentile.
Results
Using the SD definition, cutoff values for SMA and SMI were 117.04 cm2 and 39.33 cm2/m2, respectively, in men and 71.39 cm2 and 27.77 cm2/m2, respectively, in women. Using the fifth percentile definition, cutoff values for SMA and SMI were 126.88 cm2 and 40.96 cm2/m2, respectively, in men and 78.85 cm2 and 30.60 cm2/m2, respectively, in women.
Conclusion
Our data provide sex-specific cutoff values for the SMA and SMI at the L3 level measured by CT imaging in a healthy Korean population, which may be applicable for identifying sarcopenia in this population.

Citations

Citations to this article as recorded by  
  • Myosteatosis is associated with poor survival after kidney transplantation: a large retrospective cohort validation
    Jie Chen, Yue Li, Chengjie Li, Turun Song
    Abdominal Radiology.2024; 49(4): 1210.     CrossRef
  • The effect of biological agent on body composition in patients with Crohn’s disease
    Eun Jeong Choi, Dong Hoon Baek, Hong Sub Lee, Geun Am Song, Tae Oh Kim, Yong Eun Park, Chang Min Lee, Jong Hoon Lee
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • The Association between the L3 Skeletal Muscle Index Derived from Computed Tomography and Clinical Outcomes in Patients with Urinary Tract Infection in the Emergency Department
    Jinjoo An, Seung Pill Choi, Jae Hun Oh, Jong Ho Zhu, Sung Wook Kim, Soo Hyun Kim
    Journal of Clinical Medicine.2023; 12(15): 5024.     CrossRef
  • Validity of computed tomography defined body composition as a prognostic factor for functional outcome after kidney transplantation
    Tim D. A. Swaab, Evelien E. Quint, Lisa B. Westenberg, Marcel Zorgdrager, Dorry L. Segev, Mara A. McAdams‐DeMarco, Stephan J. L. Bakker, Alain R. Viddeleer, Robert A. Pol
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(6): 2532.     CrossRef
  • Assessment of the Diaphragm Thickness Decrease in Critically Ill COVID-19 Patients: Could Computed Tomography Be of Aid Regarding Diaphragm Muscle Mass?
    Oana-Elena Branea, Sanda Maria Copotoiu, Diana Andreea Becica, AnaMaria Romina Budeanu, Razvan Gabriel Budeanu, Mihai Emanuel Becica, Dragos Constantin Cucoranu, Septimiu Voidazan, Monica Chis, Alexandra Elena Lazar
    Cureus.2023;[Epub]     CrossRef
  • Clinical implication of thoracic skeletal muscle volume as a predictor of ventilation-weaning failure in brain-injured patients: A retrospective observational study
    Jimi Oh, Hyun Lim, Chang Won Jeong, Min Su Kim, Jinseok Lee, Wu Seong Kang, Ui Ri An, Joo Un Park, Youngick Ahn, Youe Ree Kim, Chul Park
    Medicine.2023; 102(43): e35847.     CrossRef
  • Estimation of Muscle Mass Using Creatinine/Cystatin C Ratio in Japanese Community-Dwelling Older People
    Hiroshi Kusunoki, Yasuharu Tabara, Shotaro Tsuji, Yosuke Wada, Kayoko Tamaki, Koutatsu Nagai, Masako Itoh, Kyoko Sano, Manabu Amano, Hatsuo Maeda, Hideyuki Sugita, Yoko Hasegawa, Hiromitsu Kishimoto, Soji Shimomura, Michiya Igase, Ken Shinmura
    Journal of the American Medical Directors Association.2022; 23(5): 902.e21.     CrossRef
  • Defining reference values for low skeletal muscle index at the L3 vertebra level based on computed tomography in healthy adults: A multicentre study
    Ming Kong, Nan Geng, Ying Zhou, Ning Lin, Wenyan Song, Manman Xu, Shanshan Li, Yuetong Piao, Zuoqing Han, Rong Guo, Chao Yang, Nan Luo, Zhong Wang, Mengyuan Jiang, Lili Wang, Wanchun Qiu, Junfeng Li, Daimeng Shi, Rongkuan Li, Eddie C. Cheung, Yu Chen, Zho
    Clinical Nutrition.2022; 41(2): 396.     CrossRef
  • The Value of Artificial Intelligence-Assisted Imaging in Identifying Diagnostic Markers of Sarcopenia in Patients with Cancer
    Ying-Tzu Huang, Yi-Shan Tsai, Peng-Chan Lin, Yu-Min Yeh, Ya-Ting Hsu, Pei-Ying Wu, Meng-Ru Shen, Zhongjie Shi
    Disease Markers.2022; 2022: 1.     CrossRef
  • Assessment of Muscle Quantity, Quality and Function
    Bo Kyung Koo
    Journal of Obesity & Metabolic Syndrome.2022; 31(1): 9.     CrossRef
  • Computed Tomography-Derived Skeletal Muscle Radiodensity Is an Early, Sensitive Marker of Age-Related Musculoskeletal Changes in Healthy Adults
    Yeon Woo Jung, Namki Hong, Joon Chae Na, Woong Kyu Han, Yumie Rhee
    Endocrinology and Metabolism.2021; 36(6): 1201.     CrossRef
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Namgok Lecture 2019
Obesity and Metabolism
Impact of Skeletal Muscle Mass on Metabolic Health
Gyuri Kim, Jae Hyeon Kim
Endocrinol Metab. 2020;35(1):1-6.   Published online March 19, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.1.1
  • 11,279 View
  • 301 Download
  • 68 Web of Science
  • 71 Crossref
AbstractAbstract PDFPubReader   ePub   

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diseases, including metabolic syndrome and non-alcoholic fatty liver disease.

Citations

Citations to this article as recorded by  
  • Sex differences in the association between dual‐energy x‐ray absorptiometry‐measured body composition and periodontitis
    Peijun Zhu, An Li, Qingqing Cai, Yuntao Chen, Yang Liu, Harriët Jager‐Wittenaar, Geerten‐Has E. Tjakkes, Shulan Xu
    Journal of Periodontology.2024; 95(3): 219.     CrossRef
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Close layer
Review Article
Obesity and Metabolism
Connecting Myokines and Metabolism
Rexford S. Ahima, Hyeong-Kyu Park
Endocrinol Metab. 2015;30(3):235-245.   Published online August 4, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.3.235
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AbstractAbstract PDFPubReader   

Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus contributing to energy homeostasis and the pathogenesis of obesity, diabetes, and other diseases. In this review, we summarize recent findings on the biology of myokines and provide an assessment of their potential as therapeutic targets.

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Original Article
Thyroid
Expression of Thyroid Stimulating Hormone Receptor mRNA in Mouse C2C12 Skeletal Muscle Cells
Jung Hun Ohn, Sun Kyoung Han, Do Joon Park, Kyong Soo Park, Young Joo Park
Endocrinol Metab. 2013;28(2):119-124.   Published online June 18, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.2.119
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AbstractAbstract PDFPubReader   
Background

We analyzed whether thyroid stimulating hormone receptor (TSH-R) is expressed in a skeletal muscle cell line and if TSH has influence on the differentiation of muscle cells or on the determination of muscle fiber types.

Methods

TSH-R gene expression was detected with nested real-time polymerase chain reaction (RT-PCR) in C2C12, a mouse skeletal muscle cell line. The effect of TSH on myotube differentiation was assessed by microscopic examination of myotube formation and through the measurement of expression of muscle differentiation markers, i.e., myogenin and myoD, and muscle type-specific genes, i.e., MyHC1, MyHC2a, and MyHC2b, with quantitative RT-PCR before and after incubation of C2C12 myotube with TSH.

Results

TSH-R was expressed in the mouse skeletal muscle cell line. However, treatment with TSH had little effect on the differentiation of muscle cells, although the expression of the muscle differention marker myogenin was significantly increased after TSH treatment. Treatment of TSH did not affect the expression of muscle type-specific genes.

Conclusion

TSH-R is expressed in a mouse skeletal muscle cell line, but the role of TSH receptor signaling in skeletal muscle needs further investigation.

Citations

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Endocrinol Metab : Endocrinology and Metabolism