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1 "Phthalic acids"
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Diabetes, Obesity and Metabolism
Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017
Moon Young Seo, Shinje Moon, Shin-Hye Kim, Mi Jung Park
Endocrinol Metab. 2022;37(2):249-260.   Published online April 7, 2022
DOI: https://doi.org/10.3803/EnM.2021.1235
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  • 7 Web of Science
  • 8 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Phthalates and bisphenol A (BPA) are synthetic chemicals widely used in daily life. This study investigated urinary phthalate and BPA levels in Korean children and their associations with obesity. Methods: A total of 2,351 children aged 3 to 17 years who participated in the Korean National Environmental Health Survey 2015 to 2017 were included. Urinary dilution was corrected using covariate-adjusted standardization (CAS). We examined the geometric mean (GM) concentrations of urinary phthalate metabolites, including di (2-ethylhexyl) phthalate (DEHP) metabolites (mono [2-ethyl-5-hydroxyhexyl] phthalate, mono [2-ethyl-5-oxohexyl] phthalate, and mono [2-ethyl-5-carboxypentyl] phthalate [MECPP]), mono-benzyl-phthalate (MBzP), mono (carboxyoctyl) phthalate (MCOP), mono (carboxy-isononyl) phthalate (MCNP), mono (3-carboxypropyl) phthalate, and mono-n-butyl-phthalate (MnBP), and BPA. We also analyzed the odds ratio (OR) for obesity according to the quartiles of each analyte. Results: The urinary GM levels of DEHP metabolites and MnBP were notably higher among Korean children than among American, Canadian, and German children. The CAS-applied GM concentrations of most analytes, except for MBzP, MCOP, and MCNP, were higher in children aged 3 to 5 years than in those aged 6 to 17 years. The OR for obesity in the highest quartile of MECPP was significantly higher than in the lowest quartile after adjusting for covariates. However, the other phthalate metabolites and BPA were not significantly associated with obesity. Conclusion: The concentrations of urinary DEHP metabolites and MnBP were higher in Korean children than in children in Western countries. Urinary MECPP exposure, but not other phthalates or BPA, showed a positive association with obesity in Korean children. Further studies are required to elucidate the causal relationships.

Citations

Citations to this article as recorded by  
  • Diethyl phthalate, a plasticizer, induces adipocyte inflammation and apoptosis in mice after long‐term dietary administration
    Shirsha Mondal, Soumyadeep Basu, Songita Ghosh, Suktara Guria, Sutapa Mukherjee
    Journal of Biochemical and Molecular Toxicology.2024;[Epub]     CrossRef
  • Nontargeted metabolomic evidence for antagonism between tetracycline and its resistance bacteria underlying their obesogenic effects on Caenorhabditis elegans
    Zhuo Li, Di Wu, Zhenyang Yu, Changzheng Cui, Daqiang Yin
    Science of The Total Environment.2023; 859: 160223.     CrossRef
  • Prospective association between phthalate exposure in childhood and liver function in adolescence: the Ewha Birth and Growth Cohort Study
    Seonhwa Lee, Hye Ah Lee, Bohyun Park, Hyejin Han, Young Sun Hong, Eun Hee Ha, Hyesook Park
    Environmental Health.2023;[Epub]     CrossRef
  • Bisphenol A substitutes and childhood obesity at 7 years: a cross-sectional study in Shandong, China
    Minyan Chen, Cheng Lv, Shanyu Zhang, Lap Ah Tse, Xinyu Hong, Xi Liu, Yu Ding, Ping Xiao, Ying Tian, Yu Gao
    Environmental Science and Pollution Research.2023; 30(29): 73174.     CrossRef
  • Association between Di-2-ethylhexyl phthalate and nonalcoholic fatty liver disease among US adults: Mediation analysis of body mass index and waist circumference in the NHANES
    Youming He, Jun Zou, Ting Hong, Dan Feng
    Food and Chemical Toxicology.2023; 179: 113968.     CrossRef
  • Association between phthalate exposure and obesity risk: A meta-analysis of observational studies
    Qian Wu, Gang Li, Chen-Yang Zhao, Xiao-Lin Na, Yun-Bo Zhang
    Environmental Toxicology and Pharmacology.2023; 102: 104240.     CrossRef
  • Levels of Bisphenol A and its analogs in nails, saliva, and urine of children: a case control study
    Yolanda Gálvez-Ontiveros, Inmaculada Moscoso-Ruiz, Vega Almazán Fernández de Bobadilla, Celia Monteagudo, Rafael Giménez-Martínez, Lourdes Rodrigo, Alberto Zafra-Gómez, Ana Rivas
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Nontargeted Metabolomic Evidence for Antagonism between Tetracycline and its Resistance Bacteria Underlying Their Obesogenic Effects on Caenorhabditis Elegans
    Zhuo Li, Zhenyang Yu, Changzheng Cui, Daqiang Yin
    SSRN Electronic Journal .2022;[Epub]     CrossRef
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