Endocrinology and Metabolism

Original Articles

Miscellaneous
Association between N-Terminal Prohormone Brain Natriuretic Peptide and Decreased Skeletal Muscle Mass in a Healthy Adult Population: A Cross-Sectional Study: Tae Kyung Yoo, Marie Yung-Chen Wu, Moon Soo Kim, Mi-Yeon Lee, Yong-Taek Lee, Kyung Jae Yoon, Chul-Hyun Park; Endocrinol Metab. 2023;38(2):269-276. Published online March 13, 2023; DOI: https://doi.org/10.3803/EnM.2022.1588

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Abstract PDF PubReader ePub Crossref - TDM: Background
Although an inverse association between the N-terminal prohormone brain natriuretic peptide (NT-proBNP) and obesity exists, only few major studies have assessed the association between NT-proBNP levels and skeletal muscle mass in asymptomatic healthy adults. Therefore, this cross-sectional study was conducted.
Methods
We assessed participants who underwent health examinations at Kangbuk Samsung Hospital in South Korea from January 2012 to December 2019. Appendicular skeletal muscle mass was measured using a bioelectrical impedance analyzer, and the skeletal muscle mass index (SMI) was calculated. Participants were divided into the control, mildly low skeletal muscle mass (LMM) (−2 standard deviation [SD] < SMI ≤−1 [SD]), and severely LMM groups (SD ≤−2) based on their SMI. The association between elevated NT-proBNP level (≥125 pg/mL) and skeletal muscle mass was assessed using multivariable logistic regression analysis with adjustment for confounding factors.
Results
This study enrolled 15,013 participants (mean age, 37.52±9.52; men, 54.24%; control, n=12,827; mildly LMM, n=1,998; severely LMM, n=188). Prevalence of elevated NT-proBNP was higher in mildly and severely LMM groups than in the control group (control, 1.19%; mildly LMM, 1.4%; severely LMM, 4.26%; P=0.001). The adjusted odds ratio (OR) of elevated NT-proBNP was significantly higher in severely LMM (OR, 2.87; 95% confidence interval [CI], 1.3 to 6.37) than in control (OR, 1.00; reference) or mildly LMM groups (OR, 1.24; 95% CI, 0.81 to 1.89).
Conclusion
Our results showed that NT-proBNP elevation were more prevalent in participants with LMM. In addition, our study showed an association between skeletal muscle mass and NT-proBNP level in a relatively young and healthy adult population.

Miscellaneous
Protective Effect of Delta-Like 1 Homolog Against Muscular Atrophy in a Mouse Model: Ji Young Lee, Minyoung Lee, Dong-Hee Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha; Endocrinol Metab. 2022;37(4):684-697. Published online August 29, 2022; DOI: https://doi.org/10.3803/EnM.2022.1446

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Abstract PDF Supplementary Material PubReader ePub Crossref - TDM: Background
Muscle atrophy is caused by an imbalance between muscle growth and wasting. Delta-like 1 homolog (DLK1), a protein that modulates adipogenesis and muscle development, is a crucial regulator of myogenic programming. Thus, we investigated the effect of exogenous DLK1 on muscular atrophy.
Methods
We used muscular atrophy mouse model induced by dexamethasone (Dex). The mice were randomly divided into three groups: (1) control group, (2) Dex-induced muscle atrophy group, and (3) Dex-induced muscle atrophy group treated with DLK1. The effects of DLK1 were also investigated in an in vitro model using C2C12 myotubes.
Results
Dex-induced muscular atrophy in mice was associated with increased expression of muscle atrophy markers and decreased expression of muscle differentiation markers, while DLK1 treatment attenuated these degenerative changes together with reduced expression of the muscle growth inhibitor, myostatin. In addition, electron microscopy revealed that DLK1 treatment improved mitochondrial dynamics in the Dex-induced atrophy model. In the in vitro model of muscle atrophy, normalized expression of muscle differentiation markers by DLK1 treatment was mitigated by myostatin knockdown, implying that DLK1 attenuates muscle atrophy through the myostatin pathway.
Conclusion
DLK1 treatment inhibited muscular atrophy by suppressing myostatin-driven signaling and improving mitochondrial biogenesis. Thus, DLK1 might be a promising candidate to treat sarcopenia, characterized by muscle atrophy and degeneration.

Calcium & Bone Metabolism
Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia: Seong Hee Ahn, Hee-Won Jung, Eunju Lee, Ji Yeon Baek, Il-Young Jang, So Jeong Park, Jin Young Lee, Eunah Choi, Yun Sun Lee, Seongbin Hong, Beom-Jun Kim; Endocrinol Metab. 2022;37(3):487-496. Published online May 27, 2022; DOI: https://doi.org/10.3803/EnM.2022.1428

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Background
Although muscles and bones interact with each other through various secretory factors, the role of sclerostin, an osteocyte-secreted factor, on muscle metabolism has not been well studied. We investigated the levels of serum sclerostin in Korean older adults with sarcopenia.
Methods
Blood samples were collected from 129 participants who underwent evaluation of muscle mass and function in an outpatient geriatric clinic of a teaching hospital. Sarcopenia and related parameters were determined using cutoff values for the Asian population. Serum sclerostin levels were measured using an enzyme-linked immunosorbent assay.
Results
The mean age of the participants was 69.6 years, and 20 participants (15.5%) were classified as having sarcopenia. After adjusting for age, sex, and body mass index, serum sclerostin levels were significantly lower in participants with sarcopenia, low muscle mass, or weak muscle strength (P=0.003 to 0.045). Serum sclerostin levels were positively associated with skeletal muscle index and grip strength after adjusting for confounders (P=0.001 and P=0.003), whereas sarcopenic phenotype score showed a negative association (P=0.006). These increases in muscle mass and strength were also dose dependent as serum sclerostin levels increased (P for trends=0.003 and P for trends=0.015). Higher serum sclerostin levels were associated with lower odds ratio (ORs) for sarcopenia, low muscle mass, and weak muscle strength after adjusting for confounders (OR, 0.27 to 0.50; P<0.001 to 0.025).
Conclusion
Higher serum sclerostin levels were associated with a lower risk of sarcopenia, low muscle mass, and weak muscle strength in Korean older adults.

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Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue
Carina O. Walowski, Catrin Herpich, Janna Enderle, Wiebke Braun, Marcus Both, Mario Hasler, Manfred J. Müller, Kristina Norman, Anja Bosy-Westphal
Scientific Reports.2023;[Epub] CrossRef
Role of the Osteocyte in Musculoskeletal Disease
Anika Shimonty, Lynda F. Bonewald, Fabrizio Pin
Current Osteoporosis Reports.2023; 21(3): 303. CrossRef
Sclerostin as a Putative Myokine in Sarcopenia
Hyon-Seung Yi
Endocrinology and Metabolism.2022; 37(3): 430. CrossRef
Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise
Giulia Minniti, Letícia Maria Pescinini-Salzedas, Guilherme Almeida dos Santos Minniti, Lucas Fornari Laurindo, Sandra Maria Barbalho, Renata Vargas Sinatora, Lance Alan Sloan, Rafael Santos de Argollo Haber, Adriano Cressoni Araújo, Karina Quesada, Jesse
International Journal of Molecular Sciences.2022; 23(21): 13452. CrossRef

Calcium & Bone Metabolism
Association between Elevated Plasma Homocysteine and Low Skeletal Muscle Mass in Asymptomatic Adults: Jae-Hyeong Choi, Jin-Woo Seo, Mi-Yeon Lee, Yong-Taek Lee, Kyung Jae Yoon, Chul-Hyun Park; Endocrinol Metab. 2022;37(2):333-343. Published online February 8, 2022; DOI: https://doi.org/10.3803/EnM.2021.1202

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Background
Homocysteine has been drawing attention with a closed linkage with skeletal muscle. However, the association of hyperhomocysteinemia with decreased skeletal muscle mass remains unclear. We aimed to investigate the association of hyperhomocysteinemia with low skeletal muscle mass (LMM) in asymptomatic adults.
Methods
This was a cross-sectional study of 114,583 community-dwelling adults without cancer, stroke, or cardiovascular diseases who underwent measurements of plasma homocysteine and body composition analysis from 2012 to 2018. Hyperhomocysteinemia was defined as >15 μmol/L. Skeletal muscle mass index (SMI) was calculated based on appendicular muscle mass (kg)/height (m)². Participants were classified into three groups based on SMI: “normal,” “mildly low,” and “severely low.”
Results
The prevalence of hyperhomocysteinemia was the highest in subjects with severely LMM (12.9%), followed by those with mildly LMM (9.8%), and those with normal muscle mass (8.5%) (P for trend <0.001). In a multivariable logistic regression model, hyperhomocysteinemia was significantly associated with having a mildly LMM (odds ratio [OR], 1.305; 95% confidence interval [CI], 1.224 to 1.392) and severely LMM (OR, 1.958; 95% CI, 1.667 to 2.286), respectively. One unit increment of log-transformed homocysteine was associated with 1.360 and 2.169 times higher risk of having mildly LMM and severely LMM, respectively.
Conclusion
We demonstrated that elevated homocysteine has an independent association with LMM in asymptomatic adults, supporting that hyperhomocysteinemia itself can be a risk for decline in skeletal musculature.

Citations

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The role of the mitochondrial trans-sulfuration in cerebro-cardio renal dysfunction during trisomy down syndrome
Sathnur Pushpakumar, Mahavir Singh, Utpal Sen, N. Tyagi, Suresh C. Tyagi
Molecular and Cellular Biochemistry.2023;[Epub] CrossRef
Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population
Tae Kyung Yoo, Hye Chang Rhim, Yong-Taek Lee, Kyung Jae Yoon, Chul-Hyun Park
Scientific Reports.2022;[Epub] CrossRef
Causal effects of homocysteine levels on the components of sarcopenia: A two-sample mendelian randomization study
Hongwei Yu, Gan Luo, Tianwei Sun, Qiong Tang
Frontiers in Genetics.2022;[Epub] CrossRef
Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study
Bing Lu, Lingyu Shen, Haiqiong Zhu, Ling Xi, Wei Wang, Xiaojun Ouyang
BMC Geriatrics.2022;[Epub] CrossRef

Calcium & Bone Metabolism
Comparison of Two DXA Systems, Hologic Horizon W and GE Lunar Prodigy, for Assessing Body Composition in Healthy Korean Adults: Seung Shin Park, Soo Lim, Hoyoun Kim, Kyoung Min Kim; Endocrinol Metab. 2021;36(6):1219-1231. Published online December 16, 2021; DOI: https://doi.org/10.3803/EnM.2021.1274

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Background
Dual-energy X-ray absorptiometry (DXA) is the most widely used method for evaluating muscle masses. The aim of this study was to investigate the agreement between muscle mass values assessed by two different DXA systems.
Methods
Forty healthy participants (20 men, 20 women; age range, 23 to 71 years) were enrolled. Total and regional body compositional values for fat and lean masses were measured consecutively with two DXA machines, Hologic Horizon and GE Lunar Prodigy. Appendicular lean mass (ALM) was calculated as the sum of the lean mass of four limbs.
Results
In both sexes, the ALM values measured by the GE Lunar Prodigy (24.8±4.3 kg in men, 15.8±2.9 kg in women) were significantly higher than those assessed by Hologic Horizon (23.0±4.0 kg in men, 14.8±3.2 kg in women). Furthermore, BMI values or body fat (%), either extremely higher or lower levels, contributed greater differences between two systems. Bland-Altman analyses revealed a significant bias between ALM values assessed by the two systems. Linear regression analyses were performed to develop equations to adjust for systematic differences (men: Horizon ALM [kg]=0.915×Lunar Prodigy ALM [kg]+0.322, R²=0.956; women: Horizon ALM [kg]=1.066×Lunar Prodigy ALM [kg]–2.064, R²=0.952).
Conclusion
Although measurements of body composition including muscle mass by the two DXA systems correlated strongly, significant differences were observed. Calibration equations should enable mutual conversion between different DXA systems.

Citations

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Total and regional appendicular skeletal muscle mass prediction from dual-energy X-ray absorptiometry body composition models
Cassidy McCarthy, Grant M. Tinsley, Anja Bosy-Westphal, Manfred J. Müller, John Shepherd, Dympna Gallagher, Steven B. Heymsfield
Scientific Reports.2023;[Epub] CrossRef
Cross-Calibration of iDXA and pQCT Scanners at Rural and Urban Research Sites in The Gambia, West Africa
Mícheál Ó Breasail, Ramatoulie Janha, Ayse Zengin, Camille Pearse, Landing Jarjou, Ann Prentice, Kate A. Ward
Calcified Tissue International.2023; 112(5): 573. CrossRef

Calcium & Bone Metabolism
Computed Tomography-Derived Skeletal Muscle Radiodensity Is an Early, Sensitive Marker of Age-Related Musculoskeletal Changes in Healthy Adults: Yeon Woo Jung, Namki Hong, Joon Chae Na, Woong Kyu Han, Yumie Rhee; Endocrinol Metab. 2021;36(6):1201-1210. Published online December 13, 2021; DOI: https://doi.org/10.3803/EnM.2021.1206

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Abstract PDF Supplementary Material PubReader ePub Crossref - TDM

Background
A decrease in computed tomography (CT)-derived skeletal muscle radiodensity (SMD) reflects age-related ectopic fat infiltration of muscle, compromising muscle function and metabolism. We investigated the age-related trajectory of SMD and its association with vertebral trabecular bone density in healthy adults.
Methods
In a cohort of healthy adult kidney donors aged 19 to 69 years (n=583), skeletal muscle index (SMI, skeletal muscle area/height2), SMD, and visceral-to-subcutaneous fat (V/S) ratio were analyzed at the level of L3 from preoperative CT scans. Low bone mass was defined as an L1 trabecular Hounsfield unit (HU) <160 HU.
Results
L3SMD showed constant decline from the second decade (annual change –0.38% and –0.43% in men and women), whereas the decline of L3SMI became evident only after the fourth decade of life (–0.37% and –0.18% in men and women). One HU decline in L3SMD was associated with elevated odds of low bone mass (adjusted odds ratio, 1.07; 95% confidence interval, 1.02 to 1.13; P=0.003), independent of L3SMI, age, sex, and V/S ratio, with better discriminatory ability compared to L3SMI (area under the receiver-operating characteristics curve 0.68 vs. 0.53, P<0.001). L3SMD improved the identification of low bone mass when added to age, sex, V/S ratio, and L3SMI (category-free net reclassification improvement 0.349, P<0.001; integrated discrimination improvement 0.015, P=0.0165).
Conclusion
L3SMD can be an early marker for age-related musculoskeletal changes showing linear decline throughout life from the second decade in healthy adults, with potential diagnostic value for individuals with low bone mass.

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A review of radiological definitions of sarcopenia in cancer
James W. Wang, Jiarong Chen, Alison H. McGregor, Matthew Williams
JCSM Clinical Reports.2023; 8(2): 36. CrossRef

Adrenal Gland
Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor: Jin Young Lee, Da Ae Kim, Eunah Choi, Yun Sun Lee, So Jeong Park, Beom-Jun Kim; Endocrinol Metab. 2021;36(4):865-874. Published online July 30, 2021; DOI: https://doi.org/10.3803/EnM.2021.1108

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Abstract PDF PubReader ePub Crossref - TDM

Background
Despite clinical evidence indicating poor muscle health in subjects with primary aldosteronism (PA), it is still unclear whether the role of aldosterone in muscle metabolism is direct or mediated indirectly via factors, such as electrolyte imbalance or impaired glucose uptake. As one approach to clarify this issue, we investigated the effect of aldosterone on in vitro myogenesis and the potential mechanism explaining it.
Methods
Myogenesis was induced in mouse C2C12 myoblasts with 2% horse serum. Immunofluorescence, quantitative reversetranscription polymerase chain reaction, Western blot, viability, and migration analyses were performed for experimental research.
Results
Recombinant aldosterone treatment suppressed muscle differentiation from mouse C2C12 myoblasts in a dose-dependent manner, and consistently reduced the expression of myogenic differentiation markers. Furthermore, aldosterone significantly increased intracellular reactive oxygen species (ROS) levels in myotubes, and treatment with N-acetyl cysteine, a potent biological thiol antioxidant, reversed the decrease of myotube area, myotube area per myotube, nucleus number per myotube, and fusion index due to aldosterone through decreasing oxidative stress. A binding enzyme-linked immunosorbent assay confirmed that mineralocorticoid receptor (MR) interacted with aldosterone in C2C12 myoblasts, while eplerenone, an MR inhibitor, blocked aldosterone-stimulated intracellular ROS generation during myogenesis and markedly attenuated the suppression of in vitro myogenesis by aldosterone.
Conclusion
These findings support the hypothesis that hypersecretion of aldosterone, like PA, directly contributes to muscular deterioration and suggest that antioxidants and/or MR antagonists could be effective therapeutic options to reduce the risk of sarcopenia in these patients.

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Role of glucocorticoid and mineralocorticoid receptors in rainbow trout (Oncorhynchus mykiss) skeletal muscle: A transcriptomic perspective of cortisol action
Jorge E. Aedo, Rodrigo Zuloaga, Daniela Aravena-Canales, Alfredo Molina, Juan Antonio Valdés
Frontiers in Physiology.2023;[Epub] CrossRef
Effect of 11-Deoxycorticosterone in the Transcriptomic Response to Stress in Rainbow Trout Skeletal Muscle
Rodrigo Zuloaga, Daniela Aravena-Canales, Jorge Eduardo Aedo, Cesar Osorio-Fuentealba, Alfredo Molina, Juan Antonio Valdés
Genes.2023; 14(2): 512. CrossRef
The Role of Aldosterone in OSA and OSA-Related Hypertension
Yi Wang, Chuan Xiang Li, Ying Ni Lin, Li Yue Zhang, Shi Qi Li, Liu Zhang, Ya Ru Yan, Fang Ying Lu, Ning Li, Qing Yun Li
Frontiers in Endocrinology.2022;[Epub] CrossRef
Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease
Daiji Kawanami, Yuichi Takashi, Yoshimi Muta, Naoki Oda, Dai Nagata, Hiroyuki Takahashi, Makito Tanabe
Frontiers in Pharmacology.2021;[Epub] CrossRef

Review Article

Diabetes, Obesity and Metabolism
Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics: Jong Hyeon Yoon, Ki-Sun Kwon; Endocrinol Metab. 2021;36(3):478-490. Published online June 28, 2021; DOI: https://doi.org/10.3803/EnM.2021.1081

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Abstract PDF PubReader ePub Crossref - TDM

Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways. Therefore, signaling receptors are major targets in pharmacological strategies in general. To provide a rationale for pharmacological interventions for sarcopenia, we herein describe several druggable signaling receptors based on their role in skeletal muscle homeostasis and changes in their activity with aging. A brief overview is presented of the efficacy of corresponding drug candidates under clinical trials. Strategies targeting the androgen receptor, vitamin D receptor, Insulin-like growth factor-1 receptor, and ghrelin receptor primarily focus on promoting anabolic action using natural ligands or mimetics. Strategies involving activin receptors and angiotensin receptors focus on inhibiting catabolic action. This review may help to select specific targets or combinations of targets in the future.

Citations

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Impact of Vitamin D Level on Sarcopenia in Elderly People: A Critical Review
Saniya Khan, Sunil Kumar, Sourya Acharya, Anil Wanjari
Journal of Health and Allied Sciences NU.2023;[Epub] CrossRef
Alverine citrate promotes myogenic differentiation and ameliorates muscle atrophy
Jong Hyeon Yoon, Seung-Min Lee, Younglang Lee, Min Ju Kim, Jae Won Yang, Jeong Yi Choi, Ju Yeon Kwak, Kwang-Pyo Lee, Yong Ryoul Yang, Ki-Sun Kwon
Biochemical and Biophysical Research Communications.2022; 586: 157. CrossRef
Adeno-associated virus-mediated expression of an inactive CaMKIIβ mutant enhances muscle mass and strength in mice
Takahiro Eguchi, Yuji Yamanashi
Biochemical and Biophysical Research Communications.2022; 589: 192. CrossRef
Gastric Mobility and Gastrointestinal Hormones in Older Patients with Sarcopenia
Hsien-Hao Huang, Tse-Yao Wang, Shan-Fan Yao, Pei-Ying Lin, Julia Chia-Yu Chang, Li-Ning Peng, Liang-Kung Chen, David Hung-Tsang Yen
Nutrients.2022; 14(9): 1897. CrossRef
Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia
Marcela Kanova, Pavel Kohout
International Journal of Molecular Sciences.2022; 23(15): 8396. CrossRef

Original Articles

Diabetes, Obesity and Metabolism
Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population: Ja Kyung Yoon, Sunyoung Lee, Kyoung Won Kim, Ji Eun Lee, Jeong Ah Hwang, Taeyong Park, Jeongjin Lee; Endocrinol Metab. 2021;36(3):672-677. Published online June 8, 2021; DOI: https://doi.org/10.3803/EnM.2021.1041

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Background
Sarcopenia is defined as the loss of skeletal muscle mass and is associated with negative clinical outcomes. This study aimed to establish sex-specific cutoff values for the skeletal muscle area (SMA) and skeletal muscle index (SMI) at the third lumbar vertebral (L3) level using computed tomography (CT) imaging to identify sarcopenia in healthy Korean liver donors.
Methods
This retrospective study included 659 healthy liver donors (408 men and 251 women) aged 20 to 60 years who had undergone abdominal CT examinations between January 2017 and December 2018. Assessment of body composition was performed with an automated segmentation technique using a deep-learning system. Sex-specific SMA and SMI distributions were assessed, and cutoff values for determining sarcopenia were defined as values at either two standard deviations (SDs) below the mean reference value or below the fifth percentile.
Results
Using the SD definition, cutoff values for SMA and SMI were 117.04 cm² and 39.33 cm²/m², respectively, in men and 71.39 cm² and 27.77 cm²/m², respectively, in women. Using the fifth percentile definition, cutoff values for SMA and SMI were 126.88 cm² and 40.96 cm²/m², respectively, in men and 78.85 cm² and 30.60 cm²/m², respectively, in women.
Conclusion
Our data provide sex-specific cutoff values for the SMA and SMI at the L3 level measured by CT imaging in a healthy Korean population, which may be applicable for identifying sarcopenia in this population.

Citations

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The effect of biological agent on body composition in patients with Crohn’s disease
Eun Jeong Choi, Dong Hoon Baek, Hong Sub Lee, Geun Am Song, Tae Oh Kim, Yong Eun Park, Chang Min Lee, Jong Hoon Lee
BMC Gastroenterology.2023;[Epub] CrossRef
Estimation of Muscle Mass Using Creatinine/Cystatin C Ratio in Japanese Community-Dwelling Older People
Hiroshi Kusunoki, Yasuharu Tabara, Shotaro Tsuji, Yosuke Wada, Kayoko Tamaki, Koutatsu Nagai, Masako Itoh, Kyoko Sano, Manabu Amano, Hatsuo Maeda, Hideyuki Sugita, Yoko Hasegawa, Hiromitsu Kishimoto, Soji Shimomura, Michiya Igase, Ken Shinmura
Journal of the American Medical Directors Association.2022; 23(5): 902.e21. CrossRef
Defining reference values for low skeletal muscle index at the L3 vertebra level based on computed tomography in healthy adults: A multicentre study
Ming Kong, Nan Geng, Ying Zhou, Ning Lin, Wenyan Song, Manman Xu, Shanshan Li, Yuetong Piao, Zuoqing Han, Rong Guo, Chao Yang, Nan Luo, Zhong Wang, Mengyuan Jiang, Lili Wang, Wanchun Qiu, Junfeng Li, Daimeng Shi, Rongkuan Li, Eddie C. Cheung, Yu Chen, Zho
Clinical Nutrition.2022; 41(2): 396. CrossRef
The Value of Artificial Intelligence-Assisted Imaging in Identifying Diagnostic Markers of Sarcopenia in Patients with Cancer
Ying-Tzu Huang, Yi-Shan Tsai, Peng-Chan Lin, Yu-Min Yeh, Ya-Ting Hsu, Pei-Ying Wu, Meng-Ru Shen, Zhongjie Shi
Disease Markers.2022; 2022: 1. CrossRef
Assessment of Muscle Quantity, Quality and Function
Bo Kyung Koo
Journal of Obesity & Metabolic Syndrome.2022; 31(1): 9. CrossRef
Computed Tomography-Derived Skeletal Muscle Radiodensity Is an Early, Sensitive Marker of Age-Related Musculoskeletal Changes in Healthy Adults
Yeon Woo Jung, Namki Hong, Joon Chae Na, Woong Kyu Han, Yumie Rhee
Endocrinology and Metabolism.2021; 36(6): 1201. CrossRef

Endocrine Research
Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults: Da Ae Kim, So Jeong Park, Jin Young Lee, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Beom-Jun Kim; Endocrinol Metab. 2021;36(2):455-465. Published online April 14, 2021; DOI: https://doi.org/10.3803/EnM.2020.942

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Background
The C-C motif chemokine ligand 11 (CCL11) has been receiving attention as a potential pro-aging factor. Accordingly, it may be involved in muscle metabolism and sarcopenia, a key component of aging phenotypes. To clarify this potential, we investigated the effects of CCL11 on in vitro muscle biology and its clinical relevance for sarcopenia parameters in older adults.
Methods
Myogenesis was induced in mouse C2C12 myoblasts with 2% horse serum. Human blood samples were collected from 79 participants who underwent a functional assessment. Thereafter, CCL11 level was measured using a quantikine ELISA kit. Sarcopenia was defined using the Asian-specific guideline.
Results
Recombinant CCL11 treatment significantly stimulated myogenesis in a dose-dependent manner, and consistently increased the expression of myogenic differentiation markers. Among the C-C chemokine receptors (CCRs), CCR5, not CCR2 and CCR3, was predominantly expressed in muscle cells. Further, the CCR5 inhibitor blocked recombinant CCL11-stimulated myogenesis. In a clinical study, serum CCL11 level was not significantly different according to the status of sarcopenia, low muscle mass, weak muscle strength, and poor physical performance, and was not associated with skeletal muscle index, grip strength, short physical performance battery score, gait speed, and time to complete 5 chair stands, after adjusting for sex, age, and body mass index.
Conclusion
Contrary to expectations, CCL11 exerted beneficial effects on muscle metabolism at least in vitro system. However, its impact on human muscle health was not evident, suggesting that circulating CCL11 may not be a useful biomarker for sarcopenia risk assessment in older adults.

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C-C motif chemokine CCL11 is a novel regulator and a potential therapeutic target in non-alcoholic fatty liver disease
Zhiwen Fan, Xinyue Sun, Xuelian Chen, Huimin Liu, Xiulian Miao, Yan Guo, Yong Xu, Jie Li, Xiaoping Zou, Zilong Li
JHEP Reports.2023; : 100754. CrossRef
Lumican Inhibits Osteoclastogenesis and Bone Resorption by Suppressing Akt Activity
Jin-Young Lee, Da-Ae Kim, Eun-Young Kim, Eun-Ju Chang, So-Jeong Park, Beom-Jun Kim
International Journal of Molecular Sciences.2021; 22(9): 4717. CrossRef
Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor
Jin Young Lee, Da Ae Kim, Eunah Choi, Yun Sun Lee, So Jeong Park, Beom-Jun Kim
Endocrinology and Metabolism.2021; 36(4): 865. CrossRef

Review Article

Miscellaneous
Sarcopenia and Muscle Aging: A Brief Overview: Tam Dao, Alexander E. Green, Yun A Kim, Sung-Jin Bae, Ki-Tae Ha, Karim Gariani, Mi-ra Lee, Keir J. Menzies, Dongryeol Ryu; Endocrinol Metab. 2020;35(4):716-732. Published online December 23, 2020; DOI: https://doi.org/10.3803/EnM.2020.405

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Abstract PDF PubReader ePub Crossref - TDM

The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns. Sarcopenia is a condition which is defined by the gradual loss of skeletal muscle mass and function with age. In research and clinical practice, sarcopenia is recognized as a component of geriatric disease and is a current target for drug development. In this review we define this condition and provide an overview of current therapeutic approaches. We further highlight recent findings that describe key pathophysiological phenotypes of this condition, including alterations in muscle fiber types, mitochondrial function, nicotinamide adenine dinucleotide (NAD⁺) metabolism, myokines, and gut microbiota, in aged muscle compared to young muscle or healthy aged muscle. The last part of this review examines new therapeutic avenues for promising treatment targets. There is still no accepted therapy for sarcopenia in humans. Here we provide a brief review of the current state of research derived from various mouse models or human samples that provide novel routes for the development of effective therapeutics to maintain muscle health during aging.

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Effects of Rosemary Extract on C2C12 Myoblast Differentiation and 5-Aminoimidazole-4-carboxamide Ribonucleoside (AICAR)-Induced Muscle Cell Atrophy
Jun Ho Lee, Jung Yoon Jang, Young Hoon Kwon, Seung Ho Lee, Cheol Park, Yung Hyun Choi, Nam Deuk Kim
Applied Sciences.2023; 13(2): 986. CrossRef
Relationship between asthma and sarcopenia in the elderly: a nationwide study from the KNHANES
Ha-Kyeong Won, Yewon Kang, Jin An, Ji-Hyang Lee, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Il-Young Jang, Tae-Bum Kim
Journal of Asthma.2023; 60(2): 304. CrossRef
A Lignan from Alnus japonica Activates Myogenesis and Alleviates Dexamethasone-induced Myotube Atrophy
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Planta Medica.2023; 89(05): 484. CrossRef
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity
Gregory Livshits, Alexander Kalinkovich
Ageing Research Reviews.2023; 86: 101852. CrossRef
Facilitators and Barriers of Tai Chi Practice in Community-Dwelling Older Adults: Qualitative Study
Yan Du, Penny Roberts, Wei Liu
Asian/Pacific Island Nursing Journal.2023; 7: e42195. CrossRef
Extract of Alnus japonica prevents dexamethasone-induced muscle atrophy in mice
Hyejin Lee, Kyeong Seon Lee, Ji Hye Jeong, Ji Soo Yoon, Seung Hwan Hwang, Sang-Yoon Kim, Sung Hum Yeon, Jae-Ha Ryu
Journal of Functional Foods.2023; 101: 105419. CrossRef
Axis “microbiota - muscle”
A. N. Zavyalova, V. P. Novikova, P. D. Ignatova
Experimental and Clinical Gastroenterology.2023; (11): 60. CrossRef
Comparison of the effects of commercial whey protein and native whey protein on muscle strength and muscle protein synthesis in rats
Jiyun Kim, Eun Woo Jeong, Youjin Baek, Gwang-woong Go, Hyeon Gyu Lee
Food Science and Biotechnology.2023; 32(3): 381. CrossRef
Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression
Jie He, Hezhi Li, Jun Yao, Yan Wang
Frontiers in Nutrition.2023;[Epub] CrossRef
Proteome network analysis of skeletal muscle in lignan-enriched nutmeg extract-fed aged mice
Je-Ho Lee, Hyuno Kang, Gyung-Tae Ban, Beom Kyu Kim, JaeHyeon Lee, Heeyoun Hwang, Hwa-Seung Yoo, Kun Cho, Jong-Soon Choi
Journal of Analytical Science and Technology.2023;[Epub] CrossRef
Aging, Physical Exercise, Telomeres, and Sarcopenia: A Narrative Review
David Hernández-Álvarez, Juana Rosado-Pérez, Graciela Gavia-García, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez, Edelmiro Santiago-Osorio, Víctor Manuel Mendoza-Núñez
Biomedicines.2023; 11(2): 598. CrossRef
Genetic and Probiotic Characteristics of Urolithin A Producing Enterococcus faecium FUA027
Mengjie Xia, Shuting Mu, Yaowei Fang, Xiaomeng Zhang, Guang Yang, Xiaoyue Hou, Fuxiang He, Yaling Zhao, Yichen Huang, Wei Zhang, Juan Shen, Shu Liu
Foods.2023; 12(5): 1021. CrossRef
A nomogram to predict the risk of sarcopenia in older people
Guangjiao Yin, Juanjuan Qin, Ziwei Wang, Fang Lv, Xujun Ye
Medicine.2023; 102(16): e33581. CrossRef
Air pollution weaken your muscle? Evidence from a cross-sectional study on sarcopenia in central China
Faxue Zhang, Tianzhou Li, Bingbing Chen, Nuoya Li, Xupeng Zhang, Shijie Zhu, Gaichan Zhao, Xiaowei Zhang, TingTing Ma, Fang Zhou, Hao Liu, Wei Zhu
Ecotoxicology and Environmental Safety.2023; 258: 114962. CrossRef
Safety and Risk Factors of Needle Thoracentesis Decompression in Tension Pneumothorax in Patients over 75 Years Old
Yanhu Wang, Lei Wang, Cheng Chen, Yifan Que, Yinyi Li, Jiang Luo, Ming Yin, Miao Lv, Guogang Xu, Anita Pye
Canadian Respiratory Journal.2023; 2023: 1. CrossRef
Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives
Spencer Cholak, James W. Saville, Xing Zhu, Alison M. Berezuk, Katharine S. Tuttle, Omid Haji-Ghassemi, Francisco J. Alvarado, Filip Van Petegem, Sriram Subramaniam
Structure.2023;[Epub] CrossRef
Sarcopenia and Cardiovascular Diseases
Abdulla A. Damluji, Maha Alfaraidhy, Noora AlHajri, Namit N. Rohant, Manish Kumar, Christina Al Malouf, Samira Bahrainy, Min Ji Kwak, Wayne B. Batchelor, Daniel E. Forman, Michael W. Rich, James Kirkpatrick, Ashok Krishnaswami, Karen P. Alexander, Gary Ge
Circulation.2023; 147(20): 1534. CrossRef
Ageing with neuromuscular disease: Implications for a lifeworld‐led care through a humanising approach
Louise Abildgaard Møller, Bente Martinsen, Ulla Werlauf, Pia Dreyer
Journal of Clinical Nursing.2022; 31(17-18): 2507. CrossRef
CT-derived relationship between low relative muscle mass and bone damage in patients with multiple myeloma undergoing stem cells transplantation
Alberto Stefano Tagliafico, Federica Rossi, Bianca Bignotti, Lorenzo Torri, Alessandro Bonsignore, Liliana Belgioia, Alida Domineitto
The British Journal of Radiology.2022;[Epub] CrossRef
A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song
Biomedicine & Pharmacotherapy.2022; 147: 112636. CrossRef
Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle
James W. Daily, Sunmin Park
Cells.2022; 11(3): 338. CrossRef
Change of Computed Tomography-Based Body Composition after Adrenalectomy in Patients with Pheochromocytoma
Yousun Ko, Heeryoel Jeong, Seungwoo Khang, Jeongjin Lee, Kyung Won Kim, Beom-Jun Kim
Cancers.2022; 14(8): 1967. CrossRef
Acute bioenergetic insulin sensitivity of skeletal muscle cells: ATP-demand-provoked glycolysis contributes to stimulation of ATP supply
Rosie A. Donnell, Jane E. Carré, Charles Affourtit
Biochemistry and Biophysics Reports.2022; 30: 101274. CrossRef
The Hunt Is On! In Pursuit of the Ideal Stem Cell Population for Cartilage Regeneration
T. Mark Campbell, F. Jeffrey Dilworth, David S. Allan, Guy Trudel
Frontiers in Bioengineering and Biotechnology.2022;[Epub] CrossRef
Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia
Seong Hee Ahn, Hee-Won Jung, Eunju Lee, Ji Yeon Baek, Il-Young Jang, So Jeong Park, Jin Young Lee, Eunah Choi, Yun Sun Lee, Seongbin Hong, Beom-Jun Kim
Endocrinology and Metabolism.2022; 37(3): 487. CrossRef
Effects of Muscles on Bone Metabolism—with a Focus on Myokines
Beom-Jun Kim
Annals of Geriatric Medicine and Research.2022; 26(2): 63. CrossRef
Sclerostin as a Putative Myokine in Sarcopenia
Hyon-Seung Yi
Endocrinology and Metabolism.2022; 37(3): 430. CrossRef
Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
Naoki Ito, Ai Takatsu, Hiromi Ito, Yuka Koike, Kiyoshi Yoshioka, Yasutomi Kamei, Shin-ichiro Imai
Cell Reports.2022; 40(4): 111131. CrossRef
Restoration of NAD+homeostasis protects C2C12 myoblasts and mouse levator ani muscle from mechanical stress-induced damage
Guotao Huang, Yong He, Li Hong, Min Zhou, Xiaohu Zuo, Zhihan Zhao
Animal Cells and Systems.2022; 26(4): 192. CrossRef
Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
Yunju Jo, Min-Kyung Yeo, Tam Dao, Jeongho Kwon, Hyon‐Seung Yi, Dongryeol Ryu
Frontiers in Oncology.2022;[Epub] CrossRef
Development and Verification of a Combined Diagnostic Model for Sarcopenia with Random Forest and Artificial Neural Network
Shangjin Lin, Cong Chen, Xiaoxi Cai, Fengjian Yang, Yongqian Fan, Rajesh Kaluri
Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef
Bronchial Asthma and Sarcopenia: An Upcoming Potential Interaction
Nikolaos D. Karakousis, Ourania S. Kotsiou, Konstantinos I. Gourgoulianis
Journal of Personalized Medicine.2022; 12(10): 1556. CrossRef
Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes
Kyohei Furukawa, Marika Kousaka, Huijuan Jia, Hisanori Kato
Nutrients.2022; 14(19): 3979. CrossRef
Normative reference values and regression equations to predict the 6-minute walk distance in the Asian adult population aged 21–80 years
Meredith T. Yeung, Melissa Y. Chan, Katherin S. Huang, Tian Jie Chen, Cyprian P. Chia, Meihiko M. Fong, Cherilyn S. Ho, Derek T. Koh, Mitchell J. Neo, Mark Tan
Hong Kong Physiotherapy Journal.2022; 42(02): 111. CrossRef
Food insecurity as a risk factor of sarcopenic obesity in older adults
Diana Fonseca-Pérez, Cecilia Arteaga-Pazmiño, Claudia P. Maza-Moscoso, Sara Flores-Madrid, Ludwig Álvarez-Córdova
Frontiers in Nutrition.2022;[Epub] CrossRef
Transcriptome Sequencing Analysis of circRNA in Skeletal Muscle between Fast- and Slow-Growing Chickens at Embryonic Stages
Genxi Zhang, Jin Zhang, Pengfei Wu, Xuanze Ling, Qifan Wang, Kaizhi Zhou, Peifeng Li, Li Zhang, Hongxin Ye, Qi Zhang, Qingyu Wei, Tao Zhang, Xinglong Wang
Animals.2022; 12(22): 3166. CrossRef
Amino Acids in Cancer and Cachexia: An Integrated View
Maurizio Ragni, Claudia Fornelli, Enzo Nisoli, Fabio Penna
Cancers.2022; 14(22): 5691. CrossRef
Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia
Mengting Yin, He Zhang, Qianhui Liu, Fei Ding, Lisha Hou, Yiping Deng, Tao Cui, Yixian Han, Yijun Chen, Chen Huang, Jirong Yue, Yong He
BMC Geriatrics.2022;[Epub] CrossRef
The inflammatory response, a mixed blessing for muscle homeostasis and plasticity
Zineb Bouredji, Anteneh Argaw, Jérôme Frenette
Frontiers in Physiology.2022;[Epub] CrossRef
Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
Da Ae Kim, So Jeong Park, Jin Young Lee, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Beom-Jun Kim
Endocrinology and Metabolism.2021; 36(2): 455. CrossRef
Association of Water Intake with Hand Grip Strength in Community-Dwelling Older Adults
Hyeonmok Kim, Sun Hee Beom, Tae Ho Kim, Beom-Jun Kim
Nutrients.2021; 13(6): 1756. CrossRef
Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics
Jong Hyeon Yoon, Ki-Sun Kwon
Endocrinology and Metabolism.2021; 36(3): 478. CrossRef
Redox Signaling and Sarcopenia: Searching for the Primary Suspect
Nicholas A. Foreman, Anton S. Hesse, Li Li Ji
International Journal of Molecular Sciences.2021; 22(16): 9045. CrossRef
Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor
Jin Young Lee, Da Ae Kim, Eunah Choi, Yun Sun Lee, So Jeong Park, Beom-Jun Kim
Endocrinology and Metabolism.2021; 36(4): 865. CrossRef
Artificial‐intelligence‐driven discovery of prognostic biomarker for sarcopenia
Heewon Chung, Yunju Jo, Dongryeol Ryu, Changwon Jeong, Seong‐Kyu Choe, Jinseok Lee
Journal of Cachexia, Sarcopenia and Muscle.2021; 12(6): 2220. CrossRef
Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients
Yun Im Lee, Ryoung-Eun Ko, Joonghyun Ahn, Keumhee C. Carriere, Jeong-Am Ryu
Journal of Clinical Medicine.2021; 11(1): 90. CrossRef
Computed Tomography-Derived Skeletal Muscle Radiodensity Is an Early, Sensitive Marker of Age-Related Musculoskeletal Changes in Healthy Adults
Yeon Woo Jung, Namki Hong, Joon Chae Na, Woong Kyu Han, Yumie Rhee
Endocrinology and Metabolism.2021; 36(6): 1201. CrossRef

Original Article

Clinical Study
Relationship of Sarcopenia with Microcirculation Measured by Skin Perfusion Pressure in Patients with Type 2 Diabetes: Chan-Hee Jung, Yoon Young Cho, Dughyun Choi, Bo-Yeon Kim, Chul-Hee Kim, Ji-Oh Mok; Endocrinol Metab. 2020;35(3):578-586. Published online September 22, 2020; DOI: https://doi.org/10.3803/EnM.2020.679

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Background
Few studies have examined the relationship of sarcopenia with the microcirculation. The current study investigated the relationship of sarcopenia with microcirculatory function, as assessed by skin perfusion pressure (SPP), in type 2 diabetes mellitus (T2DM) patients.
Methods
In total, 102 T2DM patients who underwent SPP measurements and bioelectrical impedance analysis (BIA) were enrolled in this cross-sectional study. SPP was assessed using the laser Doppler technique. Sarcopenia was defined as low height-adjusted appendicular muscle mass (men, <7 kg/m²; women, <5.7 kg/m²) using BIA. We divided the participants into two groups based on SPP (≤50 and >50 mm Hg), and an SPP below 50 mm Hg was considered to reflect impaired microcirculation.
Results
Fourteen patients (13.7%) were diagnosed with impaired microcirculatory function of the lower limb based on SPP. The prevalence of sarcopenia in all subjects was 11.8%, but the percentage of patients with an SPP ≤50 mm Hg who had sarcopenia was more than triple that of patients with an SPP >50 mm Hg (28.6% vs. 9.1%, P=0.036). A significant positive correlation was found between SPP and appendicular muscle mass adjusted for height (P=0.041 for right-sided SPP). Multiple logistic regression analysis showed that patients with sarcopenia had an odds ratio of 4.1 (95% confidence interval, 1.01 to 24.9) for having an SPP ≤50 mm Hg even after adjustment for confounding factors.
Conclusion
These results suggest that sarcopenia may be significantly associated with impaired microcirculation in patients with T2DM. Nonetheless, the small number of patients and wide CI require cautious interpretation of the results.

Citations

Citations to this article as recorded by

Bioelectrical Impedance Analysis for the Assessment of Body Composition in Sarcopenia and Type 2 Diabetes
Stefano Sbrignadello, Christian Göbl, Andrea Tura
Nutrients.2022; 14(9): 1864. CrossRef
Discrimination between possible sarcopenia and metabolic syndrome using the arterial pulse spectrum and machine-learning analysis
Li-Wei Wu, Te OuYoung, Yu-Chih Chiu, Ho-Feng Hsieh, Hsin Hsiu
Scientific Reports.2022;[Epub] CrossRef
The prevalence and risk factors of sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Yaqin Ai, Ruoxin Xu, Lingping Liu
Diabetology & Metabolic Syndrome.2021;[Epub] CrossRef

Namgok Lecture 2019

Obesity and Metabolism
Impact of Skeletal Muscle Mass on Metabolic Health: Gyuri Kim, Jae Hyeon Kim; Endocrinol Metab. 2020;35(1):1-6. Published online March 19, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.1.1

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Abstract PDF PubReader ePub Crossref - TDM

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diseases, including metabolic syndrome and non-alcoholic fatty liver disease.

Citations

Citations to this article as recorded by

Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions
Ilse Vanhorebeek, Jan Gunst, Michaël P Casaer, Inge Derese, Sarah Derde, Lies Pauwels, Johan Segers, Greet Hermans, Rik Gosselink, Greet Van den Berghe
Journal of the Endocrine Society.2023;[Epub] CrossRef
Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
Norsham Juliana, Liyana Azmi, Nadia Mohd Effendy, Nur Islami Mohd Fahmi Teng, Izuddin Fahmy Abu, Nur Nabilah Abu Bakar, Sahar Azmani, Noor Anisah Abu Yazit, Suhaini Kadiman, Srijit Das
Nutrients.2023; 15(3): 734. CrossRef
Molecular mechanisms of post‐burn muscle wasting and the therapeutic potential of physical exercise
Dorien Dombrecht, Ulrike Van Daele, Birgit Van Asbroeck, David Schieffelers, Pieter‐Jan Guns, Nick Gebruers, Jill Meirte, Eric van Breda
Journal of Cachexia, Sarcopenia and Muscle.2023; 14(2): 758. CrossRef
Metabolic Impact of Frailty Changes Diabetes Trajectory
Alan J. Sinclair, Ahmed H. Abdelhafiz
Metabolites.2023; 13(2): 295. CrossRef
From Single- to Multi-organ-on-a-Chip System for Studying Metabolic Diseases
Minjeong Jang, Hong Nam Kim
BioChip Journal.2023;[Epub] CrossRef
INFLUENCE OF SARCOPENIA ON THE COURSE AND PROGNOSIS IN PATIENTS WITH CHRONIC HEART FAILURE
Gulyaev N.I., Adamov A.A., Akhmetshin I.M.
"Medical & pharmaceutical journal "Pulse".2023; : 124. CrossRef
Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures
María Elena Soto, Israel Pérez-Torres, María Esther Rubio-Ruiz, Agustina Cano-Martínez, Linaloe Manzano-Pech, Verónica Guarner-Lans
International Journal of Molecular Sciences.2023; 24(5): 4534. CrossRef
Sarcoplasmic Reticulum Ca2+ Buffer Proteins: A Focus on the Yet-To-Be-Explored Role of Sarcalumenin in Skeletal Muscle Health and Disease
Elena Conte, Giorgia Dinoi, Paola Imbrici, Annamaria De Luca, Antonella Liantonio
Cells.2023; 12(5): 715. CrossRef
Antarctic krill extracts enhance muscle regeneration and muscle function via mammalian target of rapamycin regulation
Seongmin Lee, Mi-Ock Baek, Sana Abdul Khaliq, Amna Parveen, Sun Yeou Kim, Jin-Hyoung Kim, Il-Chan Kim, Mee-Sup Yoon
Journal of Functional Foods.2023; 103: 105483. CrossRef
Pharmacological and physiological roles of adipokines and myokines in metabolic-related dementia
Archana Arjunan, Juhyun Song
Biomedicine & Pharmacotherapy.2023; 163: 114847. CrossRef
The independent and joint associations among muscle strength, abdominal obesity and cardiometabolic variables among adults
Tiago Rodrigues de Lima, David Alejandro González-Chica, Xuemei Sui, Diego Augusto Santos Silva
European Journal of Sport Science.2022; 22(7): 1122. CrossRef
Mentale Gesundheit und physische Aktivität
Wolfgang Laube
Manuelle Medizin.2022; 60(1): 13. CrossRef
A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song
Biomedicine & Pharmacotherapy.2022; 147: 112636. CrossRef
Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle
James W. Daily, Sunmin Park
Cells.2022; 11(3): 338. CrossRef
Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits
Eun Kyung Choe, Manu Shivakumar, Anurag Verma, Shefali Setia Verma, Seung Ho Choi, Joo Sung Kim, Dokyoon Kim
Scientific Reports.2022;[Epub] CrossRef
Zika virus disrupts gene expression in human myoblasts and myotubes: Relationship with susceptibility to infection
Ingo Riederer, Daniella Arêas Mendes-da-Cruz, Guilherme Cordenonsi da Fonseca, Mariela Natacha González, Otavio Brustolini, Cássia Rocha, Guilherme Loss, Joseane Biso de Carvalho, Mariane Talon Menezes, Lidiane Menezes Souza Raphael, Alexandra Gerber, Myr
PLOS Neglected Tropical Diseases.2022; 16(2): e0010166. CrossRef
Teil 1: Muskeldysfunktionen – mit Training gegen Schmerz
Wolfgang Laube
Manuelle Medizin.2022; 60(2): 84. CrossRef
Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle
Liyan Fan, David R. Sweet, Erica K. Fan, Domenick A. Prosdocimo, Annmarie Madera, Zhen Jiang, Roshan Padmanabhan, Saptarsi M. Haldar, Vinesh Vinayachandran, Mukesh K. Jain
Journal of Biological Chemistry.2022; 298(6): 101926. CrossRef
An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches
Mizael C. Araújo, Suzany H. S. Soczek, Jaqueline P. Pontes, Leonardo A. C. Marques, Gabriela S. Santos, Gisele Simão, Laryssa R. Bueno, Daniele Maria-Ferreira, Marcelo N. Muscará, Elizabeth S. Fernandes
Cells.2022; 11(8): 1292. CrossRef
Effects of a 10-Week Physical Activity Intervention on Asylum Seekers’ Physiological Health
Matheus Guerra, Danilo Garcia, Maryam Kazemitabar, Erik Lindskär, Erica Schütz, Daniel Berglind
Brain Sciences.2022; 12(7): 822. CrossRef
Low muscle mass and mortality risk later in life: A 10-year follow-up study
Cristina Camargo Pereira, Valéria Pagotto, Cesar de Oliveira, Erika Aparecida Silveira, Kiyoshi Sanada
PLOS ONE.2022; 17(7): e0271579. CrossRef
Independent and joint associations of weightlifting and aerobic activity with all-cause, cardiovascular disease and cancer mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Jessica Gorzelitz, Britton Trabert, Hormuzd A Katki, Steven C Moore, Eleanor L Watts, Charles E Matthews
British Journal of Sports Medicine.2022; 56(22): 1277. CrossRef
Handgrip Strength Cutoff Value Among Korean Adolescents with Metabolic Syndrome Components: Korean National Health and Nutrition Examination Survey Data 2014–2017
Chang Hoon Lee, Jun Hyeok Lee, Yong Whi Jeong, Hong Koh, Yunkoo Kang
Metabolic Syndrome and Related Disorders.2022; 20(10): 584. CrossRef
Prevalence of adiposity-based chronic disease and its association with anthropometric and clinical indices: a cross-sectional study
Luis E González-Salazar, Aurora E Serralde-Zúñiga, Adriana Flores-López, Juan P Díaz-Sánchez, Isabel Medina-Vera, Edgar Pichardo-Ontiveros, Rocío Guizar-Heredia, Karla G Hernández-Gómez, Ana Vigil-Martínez, Liliana Arteaga-Sánchez, Azalia Avila-Nava, Nata
British Journal of Nutrition.2022; : 1. CrossRef
Physical activity level, sitting time, and skeletal muscle mass between esports players and non-esports players
Zhi H. SEE, Mohamad S. ABDUL HAMID
Gazzetta Medica Italiana Archivio per le Scienze Mediche.2022;[Epub] CrossRef
Impact of the Nutrition–Inflammation Status on the Functionality of Patients with Chronic Kidney Disease
Ángel Nogueira, Graciela Álvarez, Guillermina Barril
Nutrients.2022; 14(22): 4745. CrossRef
Does Timing Matter? A Narrative Review of Intermittent Fasting Variants and Their Effects on Bodyweight and Body Composition
Alan A. Aragon, Brad J. Schoenfeld
Nutrients.2022; 14(23): 5022. CrossRef
Sex- and region-specific associations of skeletal muscle mass with metabolic dysfunction-associated fatty liver disease
Pei Xiao, Pu Liang, Panjun Gao, Jinyi Wu
Frontiers in Endocrinology.2022;[Epub] CrossRef
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Takahiro Tomiyama, Noboru Harada, Takeo Toshima, Yuki Nakayama, Katsuya Toshida, Akinari Morinaga, Yukiko Kosai-Fujimoto, Takahiro Tomino, Takeshi Kurihara, Kazuki Takeishi, Yoshihiro Nagao, Kazutoyo Morita, Shinji Itoh, Tomoharu Yoshizumi
Transplant International.2022;[Epub] CrossRef
Handgrip Strength Is Associated with Metabolic Syndrome and Insulin Resistance in Children and Adolescents: Analysis of Korea National Health and Nutrition Examination Survey 2014–2018
Hae Woon Jung, Jieun Lee, Jaehyun Kim
Journal of Obesity & Metabolic Syndrome.2022; 31(4): 334. CrossRef
Diet quality and a traditional dietary pattern predict lean mass in Australian women: Longitudinal data from the Geelong Osteoporosis Study
Jessica A. Davis, Mohammadreza Mohebbi, Fiona Collier, Amy Loughman, Nitin Shivappa, James R. Hébert, Julie A. Pasco, Felice N. Jacka
Preventive Medicine Reports.2021; 21: 101316. CrossRef
Association between serum FGF21 level and sarcopenia in older adults
Hee-Won Jung, Jin Hoon Park, Da Ae Kim, Il-Young Jang, So Jeong Park, Jin Young Lee, Seungjoo Lee, Jeoung Hee Kim, Hyon-Seung Yi, Eunju Lee, Beom-Jun Kim
Bone.2021; 145: 115877. CrossRef
Benchside to the bedside of frailty and cardiovascular aging: Main shared cellular and molecular mechanisms
Sandra Maria Barbalho, Ricardo José Tofano, Eduardo Federigui Baisi Chagas, Cláudia Rucco Penteado Detregiachi, Ricardo de Alvares Goulart, Uri Arian Princ Flato
Experimental Gerontology.2021; 148: 111302. CrossRef
Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
Da Ae Kim, So Jeong Park, Jin Young Lee, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Beom-Jun Kim
Endocrinology and Metabolism.2021; 36(2): 455. CrossRef
Sarcopenic obesity as a determinant of cardiovascular disease risk in older people: a systematic review
Katherine Evans, Dima Abdelhafiz, Ahmed H Abdelhafiz
Postgraduate Medicine.2021; 133(8): 831. CrossRef
Decreased continuous sitting time increases heart rate variability in patients with cardiovascular risk factors
Natsuki Nakayama, Masahiko Miyachi, Koji Tamakoshi, Toshio Hayashi, Koji Negi, Koji Watanabe, Makoto Hirai, Sharon Mary Brownie
PLOS ONE.2021; 16(6): e0253399. CrossRef
Muskeltraining – ein universelles Medikament
Wolfgang Laube
Manuelle Medizin.2021; 59(3): 179. CrossRef
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Liya Kerem, Elizabeth A. Lawson
International Journal of Molecular Sciences.2021; 22(14): 7737. CrossRef
Weight Loss Strategies and the Risk of Skeletal Muscle Mass Loss
David McCarthy, Aloys Berg
Nutrients.2021; 13(7): 2473. CrossRef
Association of FGF‐19 and FGF‐21 levels with primary sarcopenia
Rabia Bag Soytas, Veysel Suzan, Pinar Arman, Tugce Emiroglu Gedik, Damla Unal, Mahir Cengiz, Ibrahim Murat Bolayirli, Deniz Suna Erdincler, Alper Doventas, Hakan Yavuzer
Geriatrics & Gerontology International.2021; 21(10): 959. CrossRef
Der Muskulatur mehr Aufmerksamkeit schenken!
Wolfgang Laube
Manuelle Medizin.2021; 59(4): 302. CrossRef
Methodology, clinical applications, and future directions of body composition analysis using computed tomography (CT) images: A review
Antti Tolonen, Tomppa Pakarinen, Antti Sassi, Jere Kyttä, William Cancino, Irina Rinta-Kiikka, Said Pertuz, Otso Arponen
European Journal of Radiology.2021; 145: 109943. CrossRef
Waist and hip circumference are independently associated with the risk of liver disease in population‐based studies
Oscar Danielsson, Markku J. Nissinen, Antti Jula, Veikko Salomaa, Satu Männistö, Annamari Lundqvist, Markus Perola, Fredrik Åberg
Liver International.2021; 41(12): 2903. CrossRef
Understanding of sarcopenia: from definition to therapeutic strategies
Jee Won Kim, Ryuni Kim, Hyerim Choi, Sang-Jin Lee, Gyu-Un Bae
Archives of Pharmacal Research.2021; 44(9-10): 876. CrossRef
Muscle strength and its association with cardiometabolic variables in adolescents: does the expression of muscle strength values matter?
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Original Article

Clinical Study
Changes in Body Composition According to Age and Sex among Young Non-Diabetic Korean Adults: The Kangbuk Samsung Health Study: Seul-Ki Kim, Yu-Hyun Kwon, Jung Hwan Cho, Da Young Lee, Se Eun Park, Hyung-Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee; Endocrinol Metab. 2017;32(4):442-450. Published online November 21, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.4.442

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Abstract PDF PubReader Crossref - TDM

Background

Age-related decreases in lean mass represent a serious health problem. We aimed to analyze the risks of rapid decreases in lean mass by age and sex in relatively young Korean adults during a 4-year follow-up study.

Methods

A total of 65,856 non-diabetic participants (59.5% men, mean age 39.1 years) in a health screening program were subjected to bioimpedance body composition analyses and metabolic parameter analyses at baseline and after 4 years. The participants were sub-divided according to age, and additionally to six groups by age and the degree of body weight change over the 4-year period. The actual changes in body weight, lean mass, and fat mass and the percent changes over the 4-year period were assessed.

Results

The percent change in lean mass decreased and the percent change of fat mass increased with increasing age in every age and sex group. However, the annual percent decrease in lean mass and percent increase in fat mass were significantly higher among women than among men (−0.26% vs. −0.15% and 0.34% vs. 0.42%, respectively; P<0.01). Participants who were older than 50 years and had a weight loss <−5% during the 4 years had significantly greater decreases in lean mass and smaller decreases in fat mass, compared to those who were younger than 50 years. An odds ratio analysis to determine the lowest quartile of the percent change in lean mass according to age group revealed that participants older than 60 years had a significantly increased risk of a rapid decrease in the lean mass percentage (2.081; 95% confidence interval, 1.678 to 2.581).

Conclusion

Even in this relatively young study population, the lean mass decreased significantly with age, and the risk of a rapid decrease in lean mass was higher among women than among men. Furthermore, the elderly exhibited a significantly more rapid decrease in lean mass, compared with younger participants.

Citations

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Review Article

Bone Metabolism
Dual-Energy X-Ray Absorptiometry: Beyond Bone Mineral Density Determination: Yong Jun Choi; Endocrinol Metab. 2016;31(1):25-30. Published online March 16, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.1.25

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Abstract PDF PubReader Crossref - TDM

Significant improvements in dual-energy X-ray absorptiometry (DXA) concerning quality, image resolution and image acquisition time have allowed the development of various functions. DXA can evaluate bone quality by indirect analysis of micro- and macro-architecture of the bone, which and improve the prediction of fracture risk. DXA can also detect existing fractures, such as vertebral fractures or atypical femur fractures, without additional radiologic imaging and radiation exposure. Moreover, it can assess the metabolic status by the measurement of body composition parameters like muscle mass and visceral fat. Although more studies are required to validate and clinically use these parameters, it is clear that DXA is not just for bone mineral densitometry.

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