Citations

Citations to this article as recorded by  

• The potential of flavonoids in hepatic fibrosis: A comprehensive review
  Zhu Wenbo, Han Jianwei, Liu Hua, Tang Lei, Chen Guijuan, Tian Mengfei
  Phytomedicine.2024; 133: 155932.     CrossRef
• Advancements in Plant-Based Therapeutics for Hepatic Fibrosis: Molecular Mechanisms and Nanoparticulate Drug Delivery Systems
  Alina Ciceu, Ferenc Fenyvesi, Anca Hermenean, Simona Ardelean, Simona Dumitra, Monica Puticiu
  International Journal of Molecular Sciences.2024; 25(17): 9346.     CrossRef

Citations

Citations to this article as recorded by  

• SUCNR1 Deficiency Alleviates Liver Ischemia–Reperfusion Injury by Regulating Kupffer Cell Activation and Polarization Through the ERK/NF-κB Pathway in Mice
  Huan Yang, An Wei, Xinting Zhou, Zhiwei Chen, Yiheng Wang
  Inflammation.2025;[Epub]     CrossRef
• Metabolic Sparks in the Liver: Metabolic and Epigenetic Reprogramming in Hepatic Stellate Cells Activation and Its Implications for Human Metabolic Diseases
  Yeon Jin Roh, Hyeonki Kim, Dong Wook Choi
  Diabetes & Metabolism Journal.2025; 49(3): 368.     CrossRef
• Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
  Inha Jung, Dae-Jeong Koo, Won-Young Lee
  Diabetes & Metabolism Journal.2024; 48(3): 327.     CrossRef
• Improvement effect of gemigliptin on salivary gland dysfunction in exogenous methylglyoxal-injected rats
  Woo Kwon Jung, Su-Bin Park, Hwa Young Yu, Junghyun Kim
  Heliyon.2024; 10(8): e29362.     CrossRef
• Gemigliptin mitigates TGF-β-induced renal fibrosis through FGF21-mediated inhibition of the TGF-β/Smad3 signaling pathway
  Jun-Kyu Byun, Gwon-Soo Jung
  Biochemical and Biophysical Research Communications.2024; : 150425.     CrossRef
• Interference with mitochondrial function as part of the antifibrogenic effect of Rilpivirine: A step towards novel targets in hepatic stellate cell activation
  Ana M. Benedicto, Federico Lucantoni, Isabel Fuster-Martínez, Pedro Diaz-Pozo, Dimitri Dorcaratto, Elena Muñoz-Forner, Victor M. Victor, Juan V. Esplugues, Ana Blas-García, Nadezda Apostolova
  Biomedicine & Pharmacotherapy.2024; 178: 117206.     CrossRef
• DPP-IV as a potential candidate in anti-obesity and obesity-related diseases treatment
  Xin Guo, Huolun Feng, Liyang Cai, Jiabin Zheng, Yong Li
  Biomedicine & Pharmacotherapy.2024; 180: 117464.     CrossRef
• Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction
  Thuy Linh Lai, So Young Park, Giang Nguyen, Phuc Thi Minh Pham, Seon Mee Kang, Jeana Hong, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho
  Endocrinology and Metabolism.2024; 39(6): 908.     CrossRef
• Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy
  Youngmi Song, Hyekyung Yang, Juhee Kim, Yoonjin Lee, Sung-Ho Kim, In-Gu Do, Cheol-Young Park
  Molecular Metabolism.2023; 78: 101806.     CrossRef
• DPP-4 Inhibitor in Type 2 Diabetes Mellitus Patient with Non-Alcoholic Fatty Liver Disease: Achieving Two Goals at Once?
  Ji Cheol Bae
  Endocrinology and Metabolism.2022; 37(6): 858.     CrossRef

Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory role. Taken with the fact that succinate is an intermediate metabolite in the center of mitochondrial activity, and considering its potential regulation of protein succinylation through succinyl-coenzyme A, a review on the overall multifaceted actions of succinate to discuss whether and how these actions relate to the cellular locations of succinate is much warranted. Mechanistically, it is important to consider the sources of succinate, which include somatic cellular released succinate and those produced by the microbiome, especially the gut microbiota, which is an equivalent, if not greater contributor of succinate levels in the body. Continue learning the critical roles of succinate signaling, known and unknown, in many pathophysiological conditions is important. Furthermore, studies to delineate the regulation of succinate levels and to determine how succinate elicits various types of signaling in a temporal and spatial manner are also required.

Citations

Citations to this article as recorded by  

• Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases
  Lixiao Hang, Ying Zhang, Zheng Zhang, Haiqiang Jiang, Lin Xia
  Cardiovascular Drugs and Therapy.2025; 39(3): 661.     CrossRef
• Research progress on intratumoral microorganisms in renal cancer
  Jiankun Zhang, Keyuan Lou, Junpeng Chi, Jitao Wu, Xinying Fan, Yuanshan Cui
  World Journal of Urology.2025;[Epub]     CrossRef
• Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism
  Aenne‐Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia‐Marcos, Robert Kraft, Claudia Stäubert
  The FEBS Journal.2025; 292(8): 2017.     CrossRef
• Ethanol extract of propolis relieves exercise-induced fatigue via modulating the metabolites and gut microbiota in mice
  Shan Huang, Xiaofei Yang, Jingxuan Ma, Chen Li, Yajing Wang, Zhaoxia Wu
  Frontiers in Nutrition.2025;[Epub]     CrossRef
• Innovative medical technology of succinic acid photophoresis in comorbid patients with adenomyosis
  Y. I. Uraeva, I. I. Ivanova, N. N. Lazarenko
  Fizioterapevt (Physiotherapist).2025; (2): 107.     CrossRef
• Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice
  Fangxi Xu, Yuqi Guo, Scott C. Thomas, Anish Saxena, Samantha Hwang, Mridula Vardhan, Xin Li
  International Journal of Oral Science.2025;[Epub]     CrossRef
• Exploring the shared genetic architecture of type 2 diabetes mellitus and bone mineral density
  Xinran Feng, Hongbin Xu, Qian Guo, Zeying Wang, Ruikai Ba, Kun Xuan, Jinghao Ban
  Archives of Osteoporosis.2025;[Epub]     CrossRef
• Type 2 diabetes and succinate: unmasking an age-old molecule
  Sonia Fernández-Veledo, Anna Marsal-Beltran, Joan Vendrell
  Diabetologia.2024; 67(3): 430.     CrossRef
• Retinoic Acid-Mediated Control of Energy Metabolism Is Essential for Lung Branching Morphogenesis
  Hugo Fernandes-Silva, Marco G. Alves, Marcia R. Garcez, Jorge Correia-Pinto, Pedro F. Oliveira, Catarina C. F. Homem, Rute S. Moura
  International Journal of Molecular Sciences.2024; 25(9): 5054.     CrossRef
• SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes
  Joan Sabadell-Basallote, Brenno Astiarraga, Carlos Castaño, Miriam Ejarque, Maria Repollés-de-Dalmau, Ivan Quesada, Jordi Blanco, Catalina Núñez-Roa, M-Mar Rodríguez-Peña, Laia Martínez, Dario F. De Jesus, Laura Marroquí, Ramon Bosch, Eduard Montanya, Fra
  Journal of Clinical Investigation.2024;[Epub]     CrossRef
• Exposure to Succinate Leads to Steatosis in Non-Obese Non-Alcoholic Fatty Liver Disease by Inhibiting AMPK/PPARα/FGF21-Dependent Fatty Acid Oxidation
  Hong Yang, Suye Ran, Yuxia Zhou, Qing Shi, Jiangnan Yu, Wenjuan Wang, Chengqin Sun, Dengke Li, Yue Hu, Chen Pan, Qi Yuan, Yunhuan Zhen, Qi Liu, Lingyu Song
  Journal of Agricultural and Food Chemistry.2024; 72(38): 21052.     CrossRef
• The Tricarboxylic Acid Cycle as a Central Regulator of the Rate of Aging: Implications for Metabolic Interventions
  Jonathan M. Borkum
  Advanced Biology.2023;[Epub]     CrossRef
• Dysregulation of metabolic pathways in pulmonary fibrosis
  Rishi Rajesh, Reham Atallah, Thomas Bärnthaler
  Pharmacology & Therapeutics.2023; 246: 108436.     CrossRef
• Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage
  Sarah Abdullah, Michael Ghio, Aaron Cotton-Betteridge, Aditya Vinjamuri, Robert Drury, Jacob Packer, Oguz Aras, Jessica Friedman, Mardeen Karim, David Engelhardt, Emma Kosowski, Kelby Duong, Farhana Shaheen, Patrick R. McGrew, Charles T. Harris, Robert Re
  Science Advances.2023;[Epub]     CrossRef
• Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol
  A. V. Shchulkin, P. Yu. Mylnikov, I. V. Chernykh, A. S. Esenina, E. N. Yakusheva
  Bulletin of Experimental Biology and Medicine.2023; 175(1): 54.     CrossRef
• Complex II Biology in Aging, Health, and Disease
  Eric Goetzman, Zhenwei Gong, Bob Zhang, Radhika Muzumdar
  Antioxidants.2023; 12(7): 1477.     CrossRef
• The Influence of the Microbiome on Urological Malignancies: A Systematic Review
  Joao G. Porto, Maria Camila Suarez Arbelaez, Brandon Pena, Archan Khandekar, Ankur Malpani, Bruno Nahar, Sanoj Punnen, Chad R. Ritch, Mark L. Gonzalgo, Dipen J. Parekh, Robert Marcovich, Hemendra N. Shah
  Cancers.2023; 15(20): 4984.     CrossRef
• The Gut Microbiome, Metformin, and Aging
  Sri Nitya Reddy Induri, Payalben Kansara, Scott C. Thomas, Fangxi Xu, Deepak Saxena, Xin Li
  Annual Review of Pharmacology and Toxicology.2022; 62(1): 85.     CrossRef
• Tissue- and substrate-dependent mitochondrial responses to acute hypoxia–reoxygenation stress in a marine bivalve (Crassostrea gigas )
  Linda Adzigbli, Eugene P. Sokolov, Siriluck Ponsuksili, Inna M. Sokolova
  Journal of Experimental Biology.2022;[Epub]     CrossRef
• Acute Succinate Administration Increases Oxidative Phosphorylation and Skeletal Muscle Explosive Strength via SUCNR1
  Guli Xu, Yexian Yuan, Pei Luo, Jinping Yang, Jingjing Zhou, Canjun Zhu, Qingyan Jiang, Gang Shu
  Frontiers in Veterinary Science.2022;[Epub]     CrossRef
• Integrated bioinformatics analysis identifies established and novel TGFβ1-regulated genes modulated by anti-fibrotic drugs
  Ava C. Wilson, Joe Chiles, Shah Ashish, Diptiman Chanda, Preeti L. Kumar, James A. Mobley, Enid R. Neptune, Victor J. Thannickal, Merry-Lynn N. McDonald
  Scientific Reports.2022;[Epub]     CrossRef
• SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis
  Cristina Bauset, Lluis Lis-Lopez, Sandra Coll, Laura Gisbert-Ferrándiz, Dulce C. Macias-Ceja, Marta Seco-Cervera, Francisco Navarro, Juan V. Esplugues, Sara Calatayud, Dolores Ortiz-Masia, Maria D. Barrachina, Jesús Cosín-Roger
  Biomedicines.2022; 10(3): 532.     CrossRef
• Succinate as a New Actor in Pluripotency and Early Development?
  Damien Detraux, Patricia Renard
  Metabolites.2022; 12(7): 651.     CrossRef
• Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
  Paule Bénit, Judith Goncalves, Riyad El Khoury, Malgorzata Rak, Judith Favier, Anne-Paule Gimenez-Roqueplo, Pierre Rustin
  Biomedicines.2022; 10(8): 1788.     CrossRef
• Aqueous, Non-Polymer-Based Perovskite Quantum Dots for Bioimaging: Conserving Fluorescence and Long-Term Stability via Simple and Robust Synthesis
  Sanjayan C G, Jyothi Mannekote Shivanna, Jessica D. Schiffman, Sakar Mohan, Srinivasa Budagumpi, R. Geetha Balakrishna
  ACS Applied Materials & Interfaces.2022; 14(34): 38471.     CrossRef
• Targeting the succinate receptor effectively inhibits periodontitis
  Yuqi Guo, Fangxi Xu, Scott C. Thomas, Yanli Zhang, Bidisha Paul, Satish Sakilam, Sungpil Chae, Patty Li, Caleb Almeter, Angela R. Kamer, Paramjit Arora, Dana T. Graves, Deepak Saxena, Xin Li
  Cell Reports.2022; 40(12): 111389.     CrossRef
• Gemigliptin Alleviates Succinate-Induced Hepatic Stellate Cell Activation by Ameliorating Mitochondrial Dysfunction
  Giang Nguyen, So Young Park, Dinh Vinh Do, Dae-Hee Choi, Eun-Hee Cho
  Endocrinology and Metabolism.2022; 37(6): 918.     CrossRef
• Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1
  Reham Atallah, Andrea Olschewski, Akos Heinemann
  Biomedicines.2022; 10(12): 3089.     CrossRef
• Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment
  Rania Najm, Mahmood Yaseen Hachim, Richard K. Kandasamy
  Cancers.2022; 14(24): 6064.     CrossRef
• Succinate dehydrogenase inhibitors: in silico flux analysis and in vivo metabolomics investigations show no severe metabolic consequences for rats and humans
  H. Kamp, J. Wahrheit, S. Stinchcombe, T. Walk, F. Stauber, B.v. Ravenzwaay
  Food and Chemical Toxicology.2021; 150: 112085.     CrossRef
• Can polarization of macrophage metabolism enhance cardiac regeneration?
  Connor Lantz, Amanda Becker, Edward B. Thorp
  Journal of Molecular and Cellular Cardiology.2021; 160: 87.     CrossRef
• Ethylmethylhydroxypyridine Succinate Induces Anti-inflammatory Polarization of Microglia in the Brain of Aging Rat
  Y. I. Kirova, F. M. Shakova, T. A. Voronina
  Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology.2021; 15(4): 356.     CrossRef
• Model systems in SDHx-related pheochromocytoma/paraganglioma
  Krisztina Takács-Vellai, Zsolt Farkas, Fanni Ősz, Gordon W. Stewart
  Cancer and Metastasis Reviews.2021; 40(4): 1177.     CrossRef