Endocrinology and Metabolism

Review Article

November 9, 2020

Tumor Cells and Cancer-Associated Fibroblasts: A Synergistic Crosstalk to Promote Thyroid Cancer

Laura Fozzatti, Sheue-yann Cheng

Endocrinol Metab. 2020;35(4):673-680.

Thyroid cancer is the most common endocrine malignancy. Although most thyroid cancer patients are successfully treated and have an excellent prognosis, a percentage of these patients will develop aggressive disease...

Review Article

December 23, 2020

Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations

Rachel Williams, Muthu Periasamy

Endocrinol Metab. 2020;35(4):681-695.

Obesity-associated metabolic illnesses are increasing at an alarming rate in Asian countries. A common feature observed in the Asian population is a higher incidence of abdominal obesity—the “skinny-fat” Asian syndrome....

Review Article

December 2, 2020

Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification

Yanhua Bai, Kennichi Kakudo, Chan Kwon Jung

Endocrinol Metab. 2020;35(4):696-715.

Advances in medical sciences and evidence-based medicine have led to momentous changes in classification and management of thyroid neoplasms. Much progress has been made toward avoiding overdiagnosis and overtreatment of...

Review Article

December 23, 2020

Sarcopenia and Muscle Aging: A Brief Overview

Tam Dao, Alexander E. Green, Yun A Kim, et al.

Endocrinol Metab. 2020;35(4):716-732.

The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns. Sarcopenia is a...

Review Article

December 23, 2020

In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench

Il-Young Kim, Sanghee Park, Yeongmin Kim, et al.

Endocrinol Metab. 2020;35(4):733-749.

Like other substrates, plasma glucose is in a dynamic state of constant turnover (i.e., rates of glucose appearance [Ra glucose] into and disappearance [Rd glucose] from the plasma) while staying...

Review Article

December 2, 2020

Percutaneous Adrenal Radiofrequency Ablation: A Short Review for Endocrinologists

Byung Kwan Park

Endocrinol Metab. 2020;35(4):750-755.

Image-guided radiofrequency ablation (RFA) has been accepted as a minimally invasive treatment for adrenal tumors in patients who are unable to undergo adrenalectomy. Accordingly, this treatment has become more readily...

Review Article

December 23, 2020

Coordination of Multiple Cellular Processes by NR5A1/Nr5a1

Ken-ichirou Morohashi, Miki Inoue, Takashi Baba

Endocrinol Metab. 2020;35(4):756-764.

The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to...

Review Article

December 23, 2020

Embryonic Development and Adult Regeneration of the Adrenal Gland

Ji-Hoon Kim, Man Ho Choi

Endocrinol Metab. 2020;35(4):765-773.

The adrenal gland plays a pivotal role in an organism’s health span by controlling the endocrine system. Decades of research on the adrenal gland have provided multiscale insights into the...

Review Article

December 23, 2020

Minimally Invasive Adrenal Surgery

JungHak Kwak, Kyu Eun Lee

Endocrinol Metab. 2020;35(4):774-783.

Since the introduction of minimally invasive surgery, laparoscopic adrenalectomy has become the main treatment option for adrenal masses. Various studies have reported that laparoscopic adrenalectomy showed fewer postoperative complications and...

Original Article

Clinical Study

November 25, 2020

The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies

Seo Young Sohn, Eunyoung Lee, Min Kyung Lee, et al.

Endocrinol Metab. 2020;35(4):786-800.

Background: Whether hyperthyroidism is an independent risk factor for cardiovascular events remains controversial. We aimed to evaluate the association of overt and subclinical hyperthyroidism with the risk of ischemic heart...

Original Article

Clinical Study

November 24, 2020

Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults

Sung Hye Kong, Ji Won Yoon, Jung Hee Kim, et al.

Endocrinol Metab. 2020;35(4):801-810.

Background: As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score...

Original Article

Clinical Study

November 20, 2020

Trends in the Diagnosis and Treatment of Patients with Medullary Thyroid Carcinoma in Korea

Hwa Young Ahn, Jae Eun Chae, Hyemi Moon, et al.

Endocrinol Metab. 2020;35(4):811-819.

Background: Thyroid cancer is becoming increasingly common worldwide, but little is known about the epidemiology of medullary thyroid carcinoma (MTC). This study investigated the current status of the incidence and...

Original Article

Clinical Study

November 18, 2020

Insulin Secretion and Insulin Resistance Trajectories over 1 Year after Kidney Transplantation: A Multicenter Prospective Cohort Study

Jun Bae Bang, Chang-Kwon Oh, Yu Seun Kim, et al.

Endocrinol Metab. 2020;35(4):820-829.

Background: We investigated the changing patterns of insulin secretion and resistance and risk factors contributing to the development of post-transplant diabetes mellitus (PTDM) in kidney recipients under tacrolimus-based immunosuppression regimen...

Original Article

Clinical Study

November 18, 2020

Clinical Outcomes after Early and Delayed Radioiodine Remnant Ablation in Patients with Low-Risk Papillary Thyroid Carcinoma: Propensity Score Matching Analysis

Jonghwa Ahn, Meihua Jin, Eyun Song, et al.

Endocrinol Metab. 2020;35(4):830-837.

Background: The clinical outcomes of delayed radioiodine remnant ablation (RRA) therapy in patients with low-risk papillary thyroid carcinoma (PTC) are unclear. We aimed to evaluate the clinical impact of the...

Original Article

Clinical Study

December 2, 2020

Changes in Glucose Metabolism after Adrenalectomy or Treatment with a Mineralocorticoid Receptor Antagonist for Primary Aldosteronism

Yu-Fang Lin, Kang-Yung Peng, Chia-Hui Chang, et al.

Endocrinol Metab. 2020;35(4):838-846.

Background: Data on the effects of excess aldosterone on glucose metabolism are inconsistent. This study compared the changes in glucose metabolism in patients with primary aldosteronism (PA) after adrenalectomy or...

Original Article

Clinical Study

November 18, 2020

Cross-Sectional and Longitudinal Examination of Insulin Sensitivity and Secretion across Puberty among Non-Hispanic Black and White Children

Shannon E. Marwitz, Megan V. Gaines, Sheila M. Brady, et al.

Endocrinol Metab. 2020;35(4):847-857.

Background: Few studies using criterion measures of insulin sensitivity (SI) and insulin secretory capacity (ISC) have been conducted across puberty to adulthood. We examined how SI and ISC change from...

Original Article

Clinical Study

December 23, 2020

Genetic Analysis and Clinical Characteristics of Hereditary Pheochromocytoma and Paraganglioma Syndrome in Korean Population

Heewon Choi, Kyoung Jin Kim, Namki Hong, et al.

Endocrinol Metab. 2020;35(4):858-872.

Background: Pheochromocytoma and paragangliomas (PPGL) are hereditary in approximately 30% to 40% cases. With the advancement of genetic analysis techniques, including next-generation sequencing (NGS), there were attempts to classify PPGL...

Original Article

Clinical Study

December 23, 2020

Predictive Performance of Glycated Hemoglobin for Incident Diabetes Compared with Glucose Tolerance Test According to Central Obesity

Suji Yoo, Jaehoon Jung, Hosu Kim, et al.

Endocrinol Metab. 2020;35(4):873-881.

Background: To examine whether glycated hemoglobin (HbA1c) test would be a suitable screening tool for detecting high-risk subjects for diabetes compared to oral glucose tolerance test (OGTT) according to accompanied...

Original Article

Clinical Study

December 2, 2020

Efficacy and Safety of Pitavastatin in a Real-World Setting: Observational Study Evaluating SaFety in Patient Treated with Pitavastatin in Korea (PROOF Study)

In-Kyung Jeong, Sung-Rae Kim

Endocrinol Metab. 2020;35(4):882-891.

Background: While randomized controlled trials provide useful information about drug safety and efficacy, they do not always reflect the observed results in the real world. The prospective, observational, non-comparative trial...

Original Article

Clinical Study

December 23, 2020

Association between Secondhand Smoke Exposure and Metabolic Syndrome in 118,609 Korean Never Smokers Verified by Self-Reported Questionnaire and Urine Cotinine

Ji Hye Kim, Byung Jin Kim, Young Youl Hyun, et al.

Endocrinol Metab. 2020;35(4):892-900.

Background: No study has reported the association between secondhand smoke (SHS) exposure and metabolic syndrome (MetS) in self-reported never smokers verified by both self-reported questionnaire and urine cotinine. Methods: A total...

Original Article

Clinical Study

December 10, 2020

Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea

Ji Hong You, Sang Ah Lee, Sung-Youn Chun, et al.

Endocrinol Metab. 2020;35(4):901-908.

Background: The aim of this study was to evaluate clinical outcomes in coronavirus disease 2019 (COVID-19) positive patients with type 2 diabetes compared to those without diabetes in Korea. Methods: We...

Original Article

Clinical Study

December 23, 2020

Whole Exome Sequencing Identifies Novel Genetic Alterations in Patients with Pheochromocytoma/Paraganglioma

Soo Hyun Seo, Jung Hee Kim, Man Jin Kim, et al.

Endocrinol Metab. 2020;35(4):909-917.

Background: Pheochromocytoma and paragangliomas (PPGL) are known as tumors with the highest level of heritability, approximately 30% of all cases. Clinical practice guidelines of PPGL recommend genetic testing for germline...

Original Article

Clinical Study

December 23, 2020

Efficacy of Intraoperative Neuromonitoring in Reoperation for Recurrent Thyroid Cancer Patients

Jang-il Kim, Su-jin Kim, Zhen Xu, et al.

Endocrinol Metab. 2020;35(4):918-924.

Background: The use of intraoperative neuromonitoring (IONM) in thyroid surgery to preserve recurrent laryngeal nerve (RLN) function has been widely accepted. We aimed to evaluate the usefulness of IONM in...

Original Article

Clinical Study

December 10, 2020

Association of Hyperparathyroidism and Papillary Thyroid Cancer: A Multicenter Retrospective Study

Chaiho Jeong, Hye In Kwon, Hansang Baek, et al.

Endocrinol Metab. 2020;35(4):925-932.

Background: Concomitant papillary thyroid cancer (PTC) and hyperparathyroidism (HPT) have been reported in several studies. Our study aimed to investigate the incidence of concomitant PTC in HPT patients upon preoperative...

Original Article

Clinical Study

December 23, 2020

Variabilities in Weight and Waist Circumference and Risk of Myocardial Infarction, Stroke, and Mortality: A Nationwide Cohort Study

Da Hye Kim, Ga Eun Nam, Kyungdo Han, et al.

Endocrinol Metab. 2020;35(4):933-942.

Background: Evidence regarding the association between variabilities in obesity measures and health outcomes is limited. We aimed to examine the association between variabilities in obesity measures and cardiovascular outcomes and...

Original Article

Endocrine Research

December 2, 2020

Clusterin Protects Lipotoxicity-Induced Apoptosis via Upregulation of Autophagy in Insulin-Secreting Cells

Seok-Woo Hong, Jinmi Lee, Min Jeong Kim, et al.

Endocrinol Metab. 2020;35(4):943-953.

Background: There is a great need to discover factors that could protect pancreatic β-cells from apoptosis and thus prevent diabetes mellitus. Clusterin (CLU), a chaperone protein, plays an important role...

Current Issue: Volume 35(4); Dec 2020

Endocrinology
and Metabolism

Print ISSN: 2093-596X
Online ISSN: 2093-5978

5,204	Protein Expression of Cyclin B1, Transferrin Receptor, and Fibronectin Is Correlated with the Prognosis of Adrenal Cortical Carcinoma
3,757	Effects of Cardiovascular Risk Factor Variability on Health Outcomes
3,252	Tumor Cells and Cancer-Associated Fibroblasts: A Synergistic Crosstalk to Promote Thyroid Cancer
3,971	Encountering COVID-19 as Endocrinologists
3,177	Relationships between Thigh and Waist Circumference, Hemoglobin Glycation Index, and Carotid Plaque in Patients with Type 2 Diabetes

Cited By 22	Long-Term Outcomes Following Thermal Ablation of Benign Thyroid Nodules as an Alternative to Surgery: The Importance of Controlling Regrowth
Cited By 18	Graves' Disease: Can It Be Cured?
Cited By 14	Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective
Cited By 12	Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases
Cited By 11	Genomic Characterization of Differentiated Thyroid Carcinoma