Endocrinology and Metabolism

Review Article

June 23, 2020

Encountering COVID-19 as Endocrinologists

Eun-Jung Rhee, Jung Hee Kim, Sun Joon Moon, et al.

Endocrinol Metab. 2020;35(2):197-205.

The world is entering an era of disaster and chaos due to coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. Since its first emergence...

Review Article

June 24, 2020

Precision Therapy in Acromegaly Caused by Pituitary Tumors: How Close Is It to Reality?

Cheol Ryong Ku, Vladimir Melnikov, Zhaoyun Zhang, et al.

Endocrinol Metab. 2020;35(2):206-216.

Acromegaly presents with an enigmatic range of symptoms and comorbidities caused by chronic and progressive growth hormone elevations, commonly due to endocrinologic hypersecretion from a pituitary gland tumor. Comprehensive national...

Review Article

June 24, 2020

Effects of Cardiovascular Risk Factor Variability on Health Outcomes

Seung-Hwan Lee, Mee Kyoung Kim, Eun-Jung Rhee

Endocrinol Metab. 2020;35(2):217-226.

Innumerable studies have suggested “the lower, the better” for cardiovascular risk factors, such as body weight, lipid profile, blood pressure, and blood glucose, in terms of health outcomes. However, excessively...

Review Article

June 24, 2020

Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer

Keisuke Enomoto, Muneki Hotomi

Endocrinol Metab. 2020;35(2):227-236.

Thyroid cancer cells have a high amino acid demand for proliferation, invasion, and metastasis. Amino acids are taken up by thyroid cancer cells, both thyroid follicular cell and thyroid parafollicular...

Review Article

June 24, 2020

Epidemiology of Functioning Pituitary Adenomas

Sang Ouk Chin

Endocrinol Metab. 2020;35(2):237-242.

Pituitary adenomas (PAs) are defined as benign monoclonal tumors in the pituitary gland that cause symptoms due to either hormonal hypersecretion or a space-occupying effect, and are classified as functioning...

Review Article

June 24, 2020

Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease

Dae Ho Lee

Endocrinol Metab. 2020;35(2):243-259.

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver diseases and can progress to advanced fibrosis and end-stage liver disease. Thus, intensive research has been performed to develop noninvasive...

Review Article

June 24, 2020

Recent Updates on Vascular Complications in Patients with Type 2 Diabetes Mellitus

Chan-Hee Jung, Ji-Oh Mok

Endocrinol Metab. 2020;35(2):260-271.

It is well known that patients with type 2 diabetes mellitus (T2DM) are at an increased risk of morbidity and mortality from atherosclerotic cardiovascular (CV) complications. Previously, the concept that...

Original Article

Clinical Study

June 24, 2020

Fasting and Postprandial Hyperglycemia: Their Predictors and Contributions to Overall Hyperglycemia in Korean Patients with Type 2 Diabetes

Jaecheol Moon, Ji Young Kim, Soyeon Yoo, et al.

Endocrinol Metab. 2020;35(2):290-297.

Background: This study aimed to identify factors that affect fasting hyperglycemia (FHG) and postprandial hyperglycemia (PPG) and their contributions to overall hyperglycemia in Korean patients with type 2 diabetes mellitus...

Original Article

Clinical Study

June 24, 2020

Effects of a Portfolio-Mediterranean Diet and a Mediterranean Diet with or without a Sterol-Enriched Yogurt in Individuals with Hypercholesterolemia

Yvelise Ferro, Elisa Mazza, Mariantonietta Salvati, et al.

Endocrinol Metab. 2020;35(2):298-307.

Background: A growing number of functional foods have been proposed to reduce cholesterol levels and the Portfolio Diet, which includes a combination of plant sterols, fibres, nuts, and soy protein,...

Original Article

Clinical Study

June 24, 2020

Subclinical Hypothyroidism Affects the Long-Term Outcomes of Patients Who Undergo Coronary Artery Bypass Grafting Surgery but Not Heart Valve Surgery

Hana Kim, Sung Hye Kong, Jae Hoon Moon, et al.

Endocrinol Metab. 2020;35(2):308-318.

Background: The aim of this study was to determine the associations between subclinical hypothyroidism (SCH) and long-term cardiovascular outcomes after coronary artery bypass grafting (CABG) or heart valve surgery (HVS). Methods:...

Original Article

Clinical Study

June 24, 2020

Relationships between Thigh and Waist Circumference, Hemoglobin Glycation Index, and Carotid Plaque in Patients with Type 2 Diabetes

Myung Ki Yoon, Jun Goo Kang, Seong Jin Lee, et al.

Endocrinol Metab. 2020;35(2):319-328.

Background: This study investigated the relationships of thigh and waist circumference with the hemoglobin glycation index (HGI) and carotid atherosclerosis in patients with type 2 diabetes. Methods: This observational study included...

Original Article

Clinical Study

June 24, 2020

Glycemic Efficacy and Metabolic Consequences of an Empagliflozin Add-on versus Conventional Dose-Increasing Strategy in Patients with Type 2 Diabetes Inadequately Controlled by Metformin and Sulfonylurea

Yujin Shin, Ji Hye Moon, Ho Jun Chin, et al.

Endocrinol Metab. 2020;35(2):329-338.

Background: We assessed the glucose-lowering efficacy of adding empagliflozin versus dose escalating existing medications in patients with uncontrolled type 2 diabetes (T2D). Methods: This was a 6-month retrospective case-control study in...

Original Article

Clinical Study

June 24, 2020

Long-Term Results of Thermal Ablation of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

Se Jin Cho, Jung Hwan Baek, Sae Rom Chung, et al.

Endocrinol Metab. 2020;35(2):339-350.

Background: Ultrasound-guided thermal ablations have become one of the main options for treating benign thyroid nodules. To determine efficacy of thermal ablation of benign thyroid nodules, we performed a meta-analysis...

Original Article

Clinical Study

June 24, 2020

Apolipoprotein B Levels Predict Future Development of Hypertension Independent of Visceral Adiposity and Insulin Sensitivity

Seung Jin Han, Wilfred Y. Fujimoto, Steven E. Kahn, et al.

Endocrinol Metab. 2020;35(2):351-358.

Background: High plasma apolipoprotein B (apoB) levels have been shown to be associated with hypertension, central obesity, and insulin resistance in cross-sectional research. However, it is unclear whether apoB levels...

Original Article

Clinical Study

June 24, 2020

Low Predictive Value of FRAX Adjusted by Trabecular Bone Score for Osteoporotic Fractures in Korean Women: A Community-Based Cohort Study

Hana Kim, Jung Hee Kim, Min Joo Kim, et al.

Endocrinol Metab. 2020;35(2):359-366.

Background: The value of the Fracture Risk Assessment Tool (FRAX) and the trabecular bone score (TBS) for assessing osteoporotic fracture risk has not been fully elucidated in Koreans. We conducted...

Original Article

Clinical Study

June 24, 2020

Achievement of LDL-C Targets Defined by ESC/EAS (2011) Guidelines in Risk-Stratified Korean Patients with Dyslipidemia Receiving Lipid-Modifying Treatments

Ye Seul Yang, Seo Young Lee, Jung-Sun Kim, et al.

Endocrinol Metab. 2020;35(2):367-376.

Background: This study assessed the proportion of risk-stratified Korean patients with dyslipidemia achieving their low-density lipoprotein cholesterol (LDL-C) targets as defined by the European Society of Cardiology/European Atherosclerosis Society (ESC/EAS)...

Original Article

Clinical Study

June 24, 2020

Consistency of the Glycation Gap with the Hemoglobin Glycation Index Derived from a Continuous Glucose Monitoring System

Han Na Joung, Hyuk-Sang Kwon, Ki-Hyun Baek, et al.

Endocrinol Metab. 2020;35(2):377-383.

Background: Discordances between glycated hemoglobin (HbA1c) levels and glycemic control are common in clinical practice. We aimed to investigate the consistency of the glycation gap with the hemoglobin glycation index...

Original Article

Clinical Study

June 24, 2020

Gemigliptin Inhibits Interleukin-1β–Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway

Oak-Kee Hong, Seong-Su Lee, Soon Jib Yoo, et al.

Endocrinol Metab. 2020;35(2):384-395.

Background: Endothelial-to-mesenchymal transition (EndMT) contributes to inflammatory conditions inducing conversion of endothelial cells (ECs) into activated fibroblasts, promoting fibrotic diseases. Pro-inflammatory cytokine is the most potent inducer of EndMT. We...

Original Article

Clinical Study

June 24, 2020

Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer

Hyemi Kwon, Se Eun Park, Ji-Sup Yun, et al.

Endocrinol Metab. 2020;35(2):396-406.

Background: Obesity is associated with thyroid cancer risk. Adiponectin has insulin-sensitizing and anti-inflammatory effects, while progranulin is associated with inflammation and tumorigenesis. We investigated serum adiponectin and progranulin levels in...

Original Article

Clinical Study

June 24, 2020

Effectiveness of Injecting Cold 5% Dextrose into Patients with Nerve Damage Symptoms during Thyroid Radiofrequency Ablation

Min Kyoung Lee, Jung Hwan Baek, Sae Rom Chung, et al.

Endocrinol Metab. 2020;35(2):407-415.

Background: Although radiofrequency ablation (RFA) is a safe treatment for thyroid tumors, nerve damage is a frequent complication. A previous retrospective study suggested that an injection of cold 5% dextrose...

Original Article

Clinical Study

June 24, 2020

Association of Body Mass Index with the Risk of Incident Type 2 Diabetes, Cardiovascular Disease, and All-Cause Mortality: A Community-Based Prospective Study

Ji Cheol Bae, Nam H. Cho, Jae Hyeon Kim, et al.

Endocrinol Metab. 2020;35(2):416-424.

Background: Type 2 diabetes and cardiovascular disease (CVD) are the most important sequelae of obesity and the leading cause of death. We evaluated the association between body mass index (BMI)...

Original Article

Clinical Study

June 24, 2020

Effect of Lactobacillus sakei, a Probiotic Derived from Kimchi, on Body Fat in Koreans with Obesity: A Randomized Controlled Study

Soo Lim, Ji Hye Moon, Chol Min Shin, et al.

Endocrinol Metab. 2020;35(2):425-434.

Background: The increased prevalence of obesity has led to increases in the prevalence of chronic diseases worldwide. There is interest whether probiotics have an effect on obesity, but the effectiveness...

Original Article

Clinical Study

June 24, 2020

Development and Validation of a Risk Scoring System Derived from Meta-Analyses of Papillary Thyroid Cancer

Sunghwan Suh, Tae Sik Goh, Yun Hak Kim, et al.

Endocrinol Metab. 2020;35(2):435-442.

Background: The aim of this study was to develop a scoring system to stratify the risk of papillary thyroid cancer (PTC) and to select the proper management. Methods: We performed a...

Original Article

Clinical Study

June 24, 2020

Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment

Oksana Sulaieva, Olena Chernenko, Oleksiy Selesnov, et al.

Endocrinol Metab. 2020;35(2):443-455.

Background: The relationship between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains uncertain. We assessed the impact of HT on the tumor immune microenvironment (TIME) in PTC. Methods: Thirty patients...

Original Article

Endocrine Research

June 24, 2020

Transformation of Mature Osteoblasts into Bone Lining Cells and RNA Sequencing-Based Transcriptome Profiling of Mouse Bone during Mechanical Unloading

A Ram Hong, Kwangsoo Kim, Ji Yeon Lee, et al.

Endocrinol Metab. 2020;35(2):456-469.

Background: We investigated RNA sequencing-based transcriptome profiling and the transformation of mature osteoblasts into bone lining cells (BLCs) through a lineage tracing study to better understand the effect of mechanical...

Original Article

Endocrine Research

June 24, 2020

Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A

Ko Eun Shong, Chang-Myung Oh, Jun Namkung, et al.

Endocrinol Metab. 2020;35(2):470-479.

Background: Obesity is defined as excessive fat mass and is a major cause of many chronic diseases such as diabetes, cardiovascular disease, and cancer. Increasing energy expenditure and regulating adipose...

Current Issue: Volume 35(2); Jun 2020

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Endocrinology
and Metabolism

Print ISSN: 2093-596X
Online ISSN: 2093-5978

283	Encountering COVID-19 as Endocrinologists
265	Fasting and Postprandial Hyperglycemia: Their Predictors and Contributions to Overall Hyperglycemia in Korean Patients with Type 2 Diabetes
236	Impact of Skeletal Muscle Mass on Metabolic Health
230	Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
215	Effects of Resistance Exercise on Bone Health

Cited By 30	Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease
Cited By 19	Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues
Cited By 18	Genome-Wide Association Studies of Autoimmune Thyroid Diseases, Thyroid Function, and Thyroid Cancer
Cited By 16	Effects of Resistance Exercise on Bone Health
Cited By 13	Recent Updates on the Diagnosis and Management of Cushing's Syndrome