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1Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
2Graduate School, Yonsei University College of Medicine, Seoul, Korea.
3Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Korea.
4Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
5Department of Medicine (Cardiology) and Radiology, University of Virginia Health System, Charlottesville, VA, USA.
6Second Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
7Vascular Surgery Unit, Department of Surgery, University of Ioannina, Ioannina, Greece.
8Musashino Tokusyu Hospital, Tokyo, Japan.
9Department of Biostatistics, The Catholic University of Korea, Seoul, Korea.
10Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
11Cardiovascular Research Institute and Cardiovascular Genome Center, Yonsei University College of Medicine, Seoul, Korea.
Copyright © 2018 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
AUTHOR CONTRIBUTIONS: All authors had full access to all of the data in the study and can take responsibility for the integrity of the data and the accuracy of the data analysis. Designed the study and wrote the protocol: N.H., Y.H.L., E.S.K. Supervised data collection and synthesis: E.S.K. Wrote the report and final draft of the manuscript: Y.H.L., N.H. Wrote the search strategy and undertook the literature search: K.H. Undertook all data analysis: Y.H.L., N.H. Undertook title screening, data gathering, cleaning and advised on methods, statistical analyses, and interpretation of the findings: K.T., J.A.G., C.M.K., T.K., G.N.K., H.S., C.J.L., S.H.P., B. W.L., B.S.C. Contributed equally to this work: N.H., Y.H.L. Guarantor: E.S.K. All authors contributed to the final manuscript.
MACE, major adverse cardiovascular event; DM, diabetes mellitus; BMI, body mass index; LDL-C, low density lipoprotein cholesterol; PAOD, peripheral artery occlusive disease; CV, cardiovascular; MI, myocardial infarction; TIA, transient ischemic attack; SHARP, the Study of Heart and Renal Protection; CKD, chronic kidney disease; NA, not available; USA, unstable angina; IMPROVE-IT, the Improved Reduction of Outcomes: Vytorin Efficacy International Trial; ACS, acute coronary syndrome; PRECISE-IVUS, Plaque Regression With Cholesterol Absorption Inhibitor or Synthesis Inhibitor Evaluated by Intravascular Ultrasound Study; HEAVEN, Virtual histology evaluation of atherosclerosis regression during atorvastatin and ezetimibe administration study.
aA10 atorvastatin (10 mg), S20 simvastatin (20 mg), S40 simvastatin (40 mg), R10 rosuvastatin (10 mg), E10 ezetimibe (10 mg).
RR, risk ratio; CI, confidence interval; DM, diabetes mellitus; SHARP, the Study of Heart and Renal Protection; HEAVEN, Virtual histology evaluation of atherosclerosis regression during atorvastatin and ezetimibe administration study; PRECISE-IVUS, Plaque Regression With Cholesterol Absorption Inhibitor or Synthesis Inhibitor Evaluated by Intravascular Ultrasound Study; IMPROVE-IT, The Improved Reduction of Outcomes: Vytorin Efficacy International Trial.
aDM, subgroup with diabetes in each study; bNon-DM, subgroup without diabetes in each study.