Endocrinol Metab > Volume 25(4); 2010 > Article
Endocrinology and Metabolism 2010;25(4):370-373.
DOI: https://doi.org/10.3803/EnM.2010.25.4.370    Published online December 1, 2010.
Thyroid Dysfunction Induced by Metastatic Thyroid Cancer: Report of Two Cases.
Kang Hee Ahn, Bo Kyung Choi, Won Jin Kim, Bo Gwang Choi, Yun Kyung Jeon, Sang Soo Kim, Soo Hyung Lee, Bo Hyun Kim, Yong Ki Kim, In Ju Kim
1Department of Endocrinology and Metabolism, Pusan National University, Busan, Korea. injkim@pusan.ac.kr
2Department of Endocrinology and Metabolism, Kim Yong Ki Internal Medicine Clinic, Busan, Korea.
Metastases to the thyroid gland are not frequently observed in clinical practice, although an overall incidence of secondary thyroid malignant tumors has been reported to range from 1.25% to 24% in autopsy series. Generally, patients with metastatic thyroid cancer present with euthyroidism and they do not develop thyroid dysfunction. Thyroid dysfunctions, including hypothyroidism and hyperthyroidism, rarely occur in patients with metastatic thyroid cancer. We describe here a case of hypothyroidism induced by thyroid metastasis from cancer of an unknown primary site in a 53-year-old man and another case of thyrotoxicosis induced by thyroid metastasis from lung cancer in a 65-year-old man.
Key Words: Hypothyroidism, Thyroid neoplasms, Thyrotoxicosis

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