Endocrinol Metab > Volume 32(1); 2017 > Article
Lee: Articles in Endocrinology and Metabolism in 2016

INTRODUCTION

In 2016, the journal Endocrinology and Metabolism published many excellent articles in the fields of clinical and basic endocrinology. I believe that these articles contributed to the increase of scientific knowledge and improvements in the standards of medical care. Updated information is freely available to readers according to our open-access policy. I would like to briefly present the excellent articles published in 2016 in Endocrinology and Metabolism.

ARTICLES ON THYROID DISEASE

Lo et al. [1], from the University of the Philippines, performed a retrospective cohort study of 723 patients with well-differentiated thyroid cancer, evaluating their clinicopathologic profiles, ultrasound features, management, tumor recurrence, and eventual outcome over a mean follow-up period of 5 years. Follicular thyroid cancer among Filipinos appeared to behave similarly to other racial groups.
Jeon et al. [2] evaluated the significance of telomerase reverse transcriptase (TERT) promoter mutations in Korean patients with classic papillary thyroid cancer (PTC). The prevalence of somatic TERT promoter mutations was low in Korean patients with classic PTC. Therefore, the prognostic role of TERT promoter mutations may be limited in this patient cohort.
Jauculan et al. [3] identified risk factors for recurrence in the Philippine population that could potentially be used to identify individuals for whom radioactive iodine (RAI) therapy might be beneficial. They concluded that a tumor diameter ≥2 cm and a family history of PTC were significant predictors of recurrence. RAI therapy and low initial titers of thyroglobulin (Tg) and anti-Tg antibody were significant protective factors against disease recurrence among low-risk PTC patients. Park et al. [4] evaluated the genetic predisposition to thyrotoxic periodic paralysis (TPP) in terms of the β2-adrenergic receptor, androgen receptor, and γ-aminobutyric acid receptor α3 subunit genes and found no associations of these polymorphisms with TPP. In another article, doctors from the University of the Philippines also reported that fixed-dose radioiodine was associated with a significantly lower incidence of persistent hyperthyroidism at 6 months after radioactive therapy for the treatment of Graves disease [5]. In an excellent review, Moon [6] comprehensively presented the epidemiological evidence for the associations between cognitive impairment and several endocrine risk factors, including insulin resistance, dyslipidemia, thyroid dysfunction, vitamin D deficiency, and subclinical atherosclerosis. Wiersinga [7], the editor-in-chief of European Thyroid Journal, presented a review titled ‘Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease.’ He concluded that stress may provoke Graves hyperthyroidism but not Hashimoto thyroiditis. Estrogen use has been linked to a lower prevalence of Graves disease. Kwon et al. [8] evaluated the usefulness of measuring thyroid-stimulating antibody at the time of anti-thyroid drug withdrawal for predicting relapse of Graves disease. Kim et al. [9] reported that serum triiodothyronine levels were independently associated with metabolic syndrome in 13,496 euthyroid middle-aged subjects. They proposed that longitudinal studies are needed to define this association and its potential health implications.
In the September issue of Endocrinology and Metabolism, special reviews on thyroid diseases were published [10,11,12,13]. Of particular note, Yi [10] introduced the revised 2016 Korean Thyroid Association guidelines for thyroid nodules and cancers, focusing on the differences from the 2015 American Thyroid Association guidelines in her review. Other reviews and original articles on thyroid disease also appeared in 2016 [14,15].

ARTICLES ON DIABETES, OBESITY, AND LIPID DISORDERS

Choi [16] received the Namgok Award for his work in October 2015, and wrote an excellent review on the impact of organokines on insulin resistance, inflammation, and atherosclerosis. In this review, he stressed that there is emerging evidence that skeletal muscle and the liver also function as endocrine organs that secrete myokines and hepatokines, respectively. Lee et al. [17] wrote a review about how to establish clinical prediction models. They summarized five steps for developing and validating a clinical prediction model: preparation for establishing clinical prediction models, dataset selection, handling variables, model generation, and model evaluation and validation. Oh [18] presented a beautiful review about in vivo models for incretin research. She stressed that robust increases in endogenous incretin secretion have been observed in many types of metabolic/bariatric surgery. Therefore, metabolic/bariatric surgery has been extensively studied to elucidate incretin physiology, with a focus not only on the hormones themselves but also alterations in the distribution of enteroendocrine cells and genetic expression levels of gut hormones. Hong et al. [19] studied the effects of short-term exenatide treatment on aortic pulse wave velocity (PWV) in obese type 2 diabetes mellitus (T2DM) patients. They found that short term exenatide use in obese T2DM patients at high risk in terms of cardiometabolic risk factors not only reduced body weight without muscle mass loss or changes in body fat mass, but also improved aortic PWV in accordance with the waist-to-hip ratio. Lee et al. [20] published an elegant study entitled ‘The relationship between 10-year cardiovascular risk calculated using the pooled cohort equation and the severity of non-alcoholic fatty liver disease,’ and found that among 15,913 participants, increased severity of non-alcoholic fatty liver disease showed a higher correlation with estimated 10-year cardiovascular disease risk when calculated using the pooled cohort equation than when calculated using the Framingham risk score. Tokatli et al. [21] reported the interesting electrocardiographic finding of a prolonged peak and end of the T wave interval in patients with T2DM, and Lee et al. [22] reported the effect of pitavastatin treatment on apolipoprotein B-48 and lipoprotein-associated phospholipase A2 in patients with metabolic syndrome in a randomized controlled study. Son et al. [23] published the associations of waist-height ratio with diabetes risk in a 4-year longitudinal retrospective study. Suh et al. [24] reported that glucose-dependent insulinotropic peptide levels were associated with the development of T2DM in a nested case-control study conducted in a Korean cohort. Bae et al. [25] reported the effects of dipeptidyl peptidase-4 (DPP-4) inhibitors on hyperglycemia and blood cyclosporine levels in renal transplant patients with diabetes. In the second issue of 2016, special reviews about diabetes were published [26,27,28,29,30]. Bae [27] reviewed the cardiovascular safety of diabetic drugs, and Kang and Jung [30] reviewed the cardiovascular effects of glucagon-like peptide-1 receptor agonists. Many articles on the topic of diabetes and obesity were published in the remaining issues of 2016 [31,32,33,34,35,36,37,38,39,40,41,42].

ARTICLES ON BONE, ADRENAL, AND OTHER ENDOCRINE DISEASES

Elegant and excellent works were published on the topic of bone, adrenal, and other endocrine diseases. Choi [43] reviewed the use of dual-energy X-ray absorptiometry beyond bone mineral density (BMD) determination in the March issue of this year. Choi et al. [44] reported in an original article that serum γ-glutamyl transferase was inversely associated with BMD independently of alcohol consumption. Kim and Cho [45] reported that high levels of serum DPP-4 activity were associated with low BMD in obese postmenopausal women. They found that serum DPP-4 activity was positively correlated with serum calcium concentrations, intact parathyroid hormone, and serum C-telopeptide levels. In the third issue of 2016, an original article was published about osteoporosis and the prevalence of fractures among adult Filipino men screened for BMD in a tertiary hospital [46]. They reported that of the 184 Filipino male patients, 40.2% and 29.9% had osteopenia and osteoporosis, respectively. Approximately 22% of osteopenic men and 32% of osteoporotic men had fragility fractures of the hip, spine, or forearm, a very high prevalent fracture rate. Kim et al. [47] reported the association of higher plasma macrophage migration inhibitory factor (MIF) levels with lower BMD and higher bone turnover rate in postmenopausal women. In their cross-sectional study, the odds ratio per each standard deviation increment of MIF levels for osteoporosis was 1.32 (95% confidence interval, 1.01 to 1.73). Another review and an original article on bone disease also appeared in 2016 [48,49].
Many interesting articles were published on the topic of adrenal disease. Lee et al. [50] reported the radiographic characteristics of adrenal masses in oncologic patients in the first issue of 2016. From 2000 to 2012, 131 oncologic patients with adrenal incidentalomas were reviewed retrospectively. The receiver operating characteristic curve results suggested that pre-contrast levels of >20 Hounsfield units can be used as a diagnostic reference to suggest metastasis in oncologic patients with adrenal masses. In another original article, the recovery rate of adrenal function in patients with glucocorticoid (GC)-induced secondary adrenal insufficiency (AI) was reported [51]. Adrenal function recovery was frequently achieved in patients with GC-induced secondary AI within 1 to 2 years. Additionally, an incremental cortisol response at the first short Synacthen test may be an important predictive factor of adrenal function recovery. Kim et al. [52] reported the diagnostic role of the captopril challenge test (CCT) in Korean subjects with a high aldosterone-to-renin ratio (ARR). A cut-off value of 13 ng/dL showed the highest diagnostic odds ratio considering plasma aldosterone concentration at 60 and 90 minutes post-CCT, and they concluded that the CCT test may be a reliable post-screening test to avoid hospitalization in the setting of falsely elevated ARR screening tests. Kim et al. [53] reported that the recovery of the hypothalamic-pituitary-adrenal axis was rapid in patients with subclinical Cushing syndrome. The probability of recovering adrenal function during follow-up differed significantly between patients with overt Cushing syndrome and subclinical Cushing syndrome, with significant correlations with the degree of preoperative cortisol excess. Han et al. [54] reported the prevalence of obesity and hyperglycemia in Korean men with Klinefelter syndrome in a Korean Endocrine Society Registry. The prevalence of obesity, defined as a body mass index ≥25 kg/m2 in Korean men with Klinefelter syndrome, was 42.6%, and testosterone levels were an independent risk factor for obesity and hyperglycemia.

ARTICLES ON BASIC RESEARCH

Kim et al. [55] wrote an elegant review of metabolomics in biomedical research. They reported that the transcriptome does not always correlate with the proteome and that the translated proteome might not be functionally active. Therefore, changes in the transcriptome and translated proteome do not always result in phenotypic alterations. Unlike the genome or proteome, the metabolome is often called the molecular phenotype of living organisms, and is easily translated into biological conditions and disease states. Yuk et al. [56] wrote a review about small heterodimer partner and innate immune regulation. In another review article, the mechanisms of vascular calcification focusing on the pivotal role of pyruvate dehydrogenase kinase 4 (PDK4) were presented [57]. Recent studies were summarized, showing that PDK4 is an attractive therapeutic target for the treatment of various metabolic diseases. Liu and Herbison [58] reviewed kisspeptin regulation of neuronal activity throughout the central nervous system. They provided a review of kisspeptin actions on neuronal populations throughout the brain, including the magnocellular oxytocin and vasopressin neurons, and cells within the arcuate nucleus, hippocampus, and amygdala. Kang [59] presented a beautiful review, entitled ‘Dissecting tumor-stromal interactions in breast cancer bone metastasis.’ He showed that the elevated expression of vascular cell adhesion molecule 1 in disseminated breast tumor cells mediated the recruitment of pre-osteoclasts and promoted their differentiation to mature osteoclasts during bone metastasis formation. Ku et al. [60] reported the effects of a high-fat diet and resveratrol on mitochondrial activity in brown adipocytes in an original work. Resveratrol improved insulin resistance, which might be associated with the mitochondrial activity of brown adipocytes. Gavrieli and Mantzoros [61] presented a review of novel molecules regulating energy homeostasis.

CONCLUSIONS

In this editorial, I would like to thank all the scientists who have devoted their effort to Endocrinology and Metabolism. I am deeply grateful to all readers, authors, and editors, and to the board members of the Korean Endocrine Society. Their sincere support made it possible to publish many excellent articles. I would like to specially thank Prof. Eun-Jung Rhee, one of our deputy editors, and Hye Yeon Jang, the manuscript editor of the Korean Endocrine Society. I hope that readers will benefit from Endocrinology and Metabolism.

NOTES

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

REFERENCES

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2. Jeon MJ, Kim WG, Sim S, Lim S, Kwon H, Kim TY, et al. Low prevalence of somatic TERT promoter mutations in classic papillary thyroid carcinoma. Endocrinol Metab (Seoul) 2016;31:100-104.
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3. Jauculan MC, Buenaluz-Sedurante M, Jimeno CA. Risk factors associated with disease recurrence among patients with low-risk papillary thyroid cancer treated at the University of the Philippines-Philippine General Hospital. Endocrinol Metab (Seoul) 2016;31:113-119.
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4. Park S, Kim TY, Sim S, Lim S, Kim M, Kwon H, et al. Thyrotoxic periodic paralysis and polymorphisms of the ADRB2, AR, and GABRA3 genes in men with Graves disease. Endocrinol Metab (Seoul) 2016;31:142-146.
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6. Moon JH. Endocrine risk factors for cognitive impairment. Endocrinol Metab (Seoul) 2016;31:185-192.
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7. Wiersinga WM. Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease. Endocrinol Metab (Seoul) 2016;31:213-222.
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9. Kim HJ, Bae JC, Park HK, Byun DW, Suh K, Yoo MH, et al. Triiodothyronine levels are independently associated with metabolic syndrome in euthyroid middle-aged subjects. Endocrinol Metab (Seoul) 2016;31:311-319.
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10. Yi KH. The revised 2016 Korean Thyroid Association guidelines for thyroid nodules and cancers: differences from the 2015 American Thyroid Association guidelines. Endocrinol Metab (Seoul) 2016;31:373-378.
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11. Yoo WS, Chung HK. Recent advances in autoimmune thyroid diseases. Endocrinol Metab (Seoul) 2016;31:379-385.
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12. Yim CH. Update on the management of thyroid disease during pregnancy. Endocrinol Metab (Seoul) 2016;31:386-391.
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13. Kim BH, Kim IJ. Recent updates on the management of medullary thyroid carcinoma. Endocrinol Metab (Seoul) 2016;31:392-399.
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14. Topliss DJ. Clinical update in aspects of the management of autoimmune thyroid diseases. Endocrinol Metab (Seoul) 2016;31:493-499.
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15. Kwon H, Kim WG, Eszlinger M, Paschke R, Song DE, Kim M, et al. Molecular diagnosis using residual liquid-based cytology materials for patients with nondiagnostic or indeterminate thyroid nodules. Endocrinol Metab (Seoul) 2016;31:586-591.
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16. Choi KM. The impact of organokines on insulin resistance, inflammation, and atherosclerosis. Endocrinol Metab (Seoul) 2016;31:1-6.
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17. Lee YH, Bang H, Kim DJ. How to establish clinical prediction models. Endocrinol Metab (Seoul) 2016;31:38-44.
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18. Oh TJ. In vivo models for incretin research: from the intestine to the whole body. Endocrinol Metab (Seoul) 2016;31:45-51.
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19. Hong JY, Park KY, Kim BJ, Hwang WM, Kim DH, Lim DM. Effects of short-term exenatide treatment on regional fat distribution, glycated hemoglobin levels, and aortic pulse wave velocity of obese type 2 diabetes mellitus patients. Endocrinol Metab (Seoul) 2016;31:80-85.
[CROSSREF]  [PUBMED]  [PMC] 
20. Lee JI, Kim MC, Moon BS, Song YS, Han EN, Lee HS, et al. The relationship between 10-year cardiovascular risk calculated using the pooled cohort equation and the severity of non-alcoholic fatty liver disease. Endocrinol Metab (Seoul) 2016;31:86-92.
[CROSSREF]  [PUBMED]  [PMC] 
21. Tokatli A, Kilicaslan F, Alis M, Yiginer O, Uzun M. Prolonged Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with type 2 diabetes mellitus. Endocrinol Metab (Seoul) 2016;31:105-112.
[CROSSREF]  [PUBMED]  [PMC] 
22. Lee HS, Jung CH, Kim SR, Jang HC, Park CY. PROPIT Study Team. Effect of pitavastatin treatment on ApoB-48 and Lp-PLA(2) in patients with metabolic syndrome: substudy of PROspective comparative clinical study evaluating the efficacy and safety of PITavastatin in patients with metabolic syndrome. Endocrinol Metab (Seoul) 2016;31:120-126.
[CROSSREF]  [PUBMED]  [PMC] 
23. Son YJ, Kim J, Park HJ, Park SE, Park CY, Lee WY, et al. Association of waist-height ratio with diabetes risk: a 4-year longitudinal retrospective study. Endocrinol Metab (Seoul) 2016;31:127-133.
[CROSSREF]  [PUBMED]  [PMC] 
24. Suh S, Kim MY, Kim SK, Hur KY, Park MK, Kim DK, et al. Glucose-dependent insulinotropic peptide level is associated with the development of type 2 diabetes mellitus. Endocrinol Metab (Seoul) 2016;31:134-141.
[CROSSREF]  [PUBMED]  [PMC] 
25. Bae J, Lee MJ, Choe EY, Jung CH, Wang HJ, Kim MS, et al. Effects of dipeptidyl peptidase-4 inhibitors on hyperglycemia and blood cyclosporine levels in renal transplant patients with diabetes: a pilot study. Endocrinol Metab (Seoul) 2016;31:161-167.
[CROSSREF]  [PUBMED]  [PMC] 
26. Won JC, Park TS. Recent advances in diagnostic strategies for diabetic peripheral neuropathy. Endocrinol Metab (Seoul) 2016;31:230-238.
[CROSSREF]  [PUBMED]  [PMC] 
27. Bae JC. Diabetes drugs and cardiovascular safety. Endocrinol Metab (Seoul) 2016;31:239-244.
[CROSSREF]  [PUBMED]  [PMC] 
28. Kim SS, Kim JH, Kim IJ. Current challenges in diabetic nephropathy: early diagnosis and ways to improve outcomes. Endocrinol Metab (Seoul) 2016;31:245-253.
[CROSSREF]  [PUBMED]  [PMC] 
29. Lee JH, Song SJ. Current challenges in diabetic retinopathy: are we really doing better? Endocrinol Metab (Seoul) 2016;31:254-257.
[CROSSREF] 
30. Kang YM, Jung CH. Cardiovascular effects of glucagonlike peptide-1 receptor agonists. Endocrinol Metab (Seoul) 2016;31:258-274.
[CROSSREF]  [PUBMED]  [PMC] 
31. Kim MK, Jung HS, Kwak SH, Cho YM, Park KS, Kim SY. 1,5-Anhydro-D-glucitol could reflect hypoglycemia risk in patients with type 2 diabetes receiving insulin therapy. Endocrinol Metab (Seoul) 2016;31:284-291.
[CROSSREF]  [PUBMED]  [PMC] 
32. Song SO, Lee YH, Kim DW, Song YD, Nam JY, Park KH, et al. Trends in diabetes incidence in the last decade based on Korean National Health Insurance Claims Data. Endocrinol Metab (Seoul) 2016;31:292-299.
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33. Kim JD, Kang SJ, Lee MK, Park SE, Rhee EJ, Park CY, et al. C-peptide-based index is more related to incident type 2 diabetes in non-diabetic subjects than insulin-based index. Endocrinol Metab (Seoul) 2016;31:320-327.
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34. Noh J. The diabetes epidemic in Korea. Endocrinol Metab (Seoul) 2016;31:349-353.
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35. Kim JD, Lee WY. Insulin secretory capacity and insulin resistance in Korean type 2 diabetes mellitus patients. Endocrinol Metab (Seoul) 2016;31:354-360.
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36. Lee SA, Koh G, Cho SJ, Yoo SY, Chin SO. Correlation of glypican-4 level with basal active glucagon-like peptide 1 level in patients with type 2 diabetes mellitus. Endocrinol Metab (Seoul) 2016;31:439-445.
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37. Ha KH, Kim DJ. Epidemiology of childhood obesity in Korea. Endocrinol Metab (Seoul) 2016;31:510-518.
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38. Roh E, Kim MS. Brain regulation of energy metabolism. Endocrinol Metab (Seoul) 2016;31:519-524.
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39. Choi YB. Current status of bariatric and metabolic surgery in Korea. Endocrinol Metab (Seoul) 2016;31:525-532.
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40. Ahn HJ, Moon DS, Kang DY, Lee JI, Kim DY, Kim JH, et al. Urinary albumin excretion reflects cardiovascular risk in postmenopausal women without diabetes: the 2011 to 2013 Korean National Health and Nutrition Examination Survey. Endocrinol Metab (Seoul) 2016;31:537-546.
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41. Park J, Lee ES, Lee DY, Kim J, Park SE, Park CY, et al. Waist circumference as a marker of obesity is more predictive of coronary artery calcification than body mass index in apparently healthy Korean adults: the Kangbuk Samsung Health Study. Endocrinol Metab (Seoul) 2016;31:559-566.
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42. Lee HW, Jo AR, Yi DW, Kang YH, Son SM. Prevalent rate of nonalbuminuric renal insufficiency and its association with cardiovascular disease event in Korean type 2 diabetes. Endocrinol Metab (Seoul) 2016;31:577-585.
[CROSSREF]  [PUBMED]  [PMC] 
43. Choi YJ. Dual-energy X-ray absorptiometry: beyond bone mineral density determination. Endocrinol Metab (Seoul) 2016;31:25-30.
[CROSSREF]  [PUBMED]  [PMC] 
44. Choi HS, Kim KJ, Rhee Y, Lim SK. Serum gamma-glutamyl transferase is inversely associated with bone mineral density independently of alcohol consumption. Endocrinol Metab (Seoul) 2016;31:64-71.
[CROSSREF]  [PUBMED]  [PMC] 
45. Kim SW, Cho EH. High levels of serum DPP-4 activity are associated with low bone mineral density in obese postmenopausal women. Endocrinol Metab (Seoul) 2016;31:93-99.
[CROSSREF]  [PUBMED]  [PMC] 
46. Mendoza ES, Lopez AA, Valdez VA, Mercado-Asis LB. Osteoporosis and prevalent fractures among adult Filipino men screened for bone mineral density in a tertiary hospital. Endocrinol Metab (Seoul) 2016;31:433-438.
[CROSSREF]  [PUBMED]  [PMC] 
47. Kim H, Ahn SH, Shin C, Lee SH, Kim BJ, Koh JM. The association of higher plasma macrophage migration inhibitory factor levels with lower bone mineral density and higher bone turnover rate in postmenopausal women. Endocrinol Metab (Seoul) 2016;31:454-461.
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48. Jeong HM, Cho SW, Park SI. Osteoblasts are the centerpiece of the metastatic bone microenvironment. Endocrinol Metab (Seoul) 2016;31:485-492.
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49. Salamat MR, Salamat AH, Janghorbani M. Association between obesity and bone mineral density by gender and menopausal status. Endocrinol Metab (Seoul) 2016;31:547-558.
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50. Lee JH, Kim EK, Hong AR, Roh E, Bae JH, Kim JH, et al. Radiographic characteristics of adrenal masses in oncologic patients. Endocrinol Metab (Seoul) 2016;31:147-152.
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51. Baek JH, Kim SK, Jung JH, Hahm JR, Jung J. Recovery of adrenal function in patients with glucocorticoids induced secondary adrenal insufficiency. Endocrinol Metab (Seoul) 2016;31:153-160.
[CROSSREF]  [PUBMED]  [PMC] 
52. Kim JH, Park KS, Hong AR, Shin CS, Kim SY, Kim SW. Diagnostic role of captopril challenge test in Korean subjects with high aldosterone-to-renin ratios. Endocrinol Metab (Seoul) 2016;31:277-283.
[CROSSREF]  [PUBMED]  [PMC] 
53. Kim HK, Yoon JH, Jeong YA, Kang HC. The recovery of hypothalamic-pituitary-adrenal axis is rapid in subclinical Cushing syndrome. Endocrinol Metab (Seoul) 2016;31:592-597.
[CROSSREF]  [PUBMED]  [PMC] 
54. Han SJ, Kim KS, Kim W, Kim JH, Lee YH, Nam JS, et al. Obesity and hyperglycemia in Korean men with Klinefelter syndrome: the Korean Endocrine Society Registry. Endocrinol Metab (Seoul) 2016;31:598-603.
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55. Kim SJ, Kim SH, Kim JH, Hwang S, Yoo HJ. Understanding metabolomics in biomedical research. Endocrinol Metab (Seoul) 2016;31:7-16.
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56. Yuk JM, Jin HS, Jo EK. Small heterodimer partner and innate immune regulation. Endocrinol Metab (Seoul) 2016;31:17-24.
[CROSSREF] 
57. Leem J, Lee IK. Mechanisms of vascular calcification: the pivotal role of pyruvate dehydrogenase kinase 4. Endocrinol Metab (Seoul) 2016;31:52-61.
[CROSSREF]  [PUBMED]  [PMC] 
58. Liu X, Herbison AE. Kisspeptin regulation of neuronal activity throughout the central nervous system. Endocrinol Metab (Seoul) 2016;31:193-205.
[CROSSREF]  [PUBMED]  [PMC] 
59. Kang Y. Dissecting tumor-stromal interactions in breast cancer bone metastasis. Endocrinol Metab (Seoul) 2016;31:206-212.
[CROSSREF]  [PUBMED]  [PMC] 
60. Ku CR, Cho YH, Hong ZY, Lee H, Lee SJ, Hong SS, et al. The effects of high fat diet and resveratrol on mitochondrial activity of brown adipocytes. Endocrinol Metab (Seoul) 2016;31:328-335.
[CROSSREF]  [PUBMED]  [PMC] 
61. Gavrieli A, Mantzoros CS. Novel molecules regulating energy homeostasis: physiology and regulation by macronutrient intake and weight loss. Endocrinol Metab (Seoul) 2016;31:361-372.
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