Endocrinol Metab > Volume 24(4); 2009 > Article
Journal of Korean Endocrine Society 2009;24(4):272-276.
DOI: https://doi.org/10.3803/jkes.2009.24.4.272    Published online December 1, 2009.
A Case of Graves' Disease with Pancytopenia.
Jong Ho Shin, Hyun Jin Kim, Si Bum Kim, Dong Pil Kim, Bong Suk Ko, Dong Soon Kim, Ji Myung Kim, Soo Jung Gong, Jung Ae Lee
1Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
2Department of Labolatory Medicine, Eulji University School of Medicine, Daejeon, Korea.
Abstract
Hematological disorders, and especially single lineage abnormalities, have been described in patients suffering with thyrotoxicosis, but pancytopenia is a rare complication of thyrotoxicosis. Pancytopenia with thyrotoxicosis has been reported to be totally reversible with antithyroid drug treatment. We experienced a case with pancytopenia associated with Graves' disease in a 57-year-old woman who had no specific cause of pancytopenia. She presented with dyspnea and palpitation. The laboratory findings revealed thyrotoxicosis and pancytopenia. Increased radioisotope uptake was seen on the thyroid scan and normal cellularity and maturation were found in the bone marrow aspiration biopsy. Based on these findings, she was diagnosed as suffering from Gravesyendisease with pancytopenia. After treatment with propylthiouracil, the blood cell counts were restored to normal as the patient achieved a euthyroid state. We report here on a case of Graves' disease that was complicated by pancytopenia, and all this was normalized after treatment for hyperthyroidism.
Key Words: Graves' disease, pancytopenia, thyrotoxicosis


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