Endocrinol Metab > Volume 36(2); 2021 > Article
Cho, Min, Choi, Choi, and Kim: Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing
Endocrinol Metab 2017;32:296-301.
In the published article, there was an incorrect amino acid change in Table 1. The “p.Ser383Pro” should be changed to “p.Ser383Leu.” The corrected table is shown below.
We would like to apologize for any inconvenience or misunderstanding.
Table 1
Bioinformatics Analysis of GCK Mutations
Case GCK exon PolyPhen-2/SIFT prediction Amino acid change DUET predicted stability changes (ΔΔG) Reference
Family 1 2 1/Damaging c.92T>C, p.Leu30Pro −2.175 Kcal/mol (Destabilizing) [6]
Family 2 9 1/Damaging c.1151C>T, p.Ser383Leu −0.465 Kcal/mol (Destabilizing) [6]

Two mutations were predicted to be deleterious using online prediction tools. DUET is a web server that uses an integrated computational approach to study missense mutations in proteins; it is available at http://structure.bioc.cam.ac.uk/duet.

GCK, glucokinase; PolyPhen-2, polymorphism phenotyping v2.



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