Endocrinol Metab > Volume 24(3); 2009 > Article
Journal of Korean Endocrine Society 2009;24(3):206-211.
DOI: https://doi.org/10.3803/jkes.2009.24.3.206    Published online September 1, 2009.
The Case of Accelerated Linear Growth Despite Growth Hormone and Insulin-like Growth Factor-I Deficiency.
Kyeong Ju Lee, Jong Ryeal Hahm, Tae Sik Jung, Jung Hwa Jung, Soo Kyoung Kim, Jong Ha Baek, Won Hyun Lee, Han wook Yoo, Soon Il Chung
1Department of Internal Medicine, School of Medicine, Gyeongsang Institute of Health Science, Gyeongsang National University, Korea.
2Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Korea.
Abstract
Here we describe a male patient who attained normal height despite combined hypopituitarism with an abnormal growth hormone-insulin-like growth factor (IGF)-I axis. When he was an 18-year-old, he presented with a short stature and underdeveloped external genitalia. The patient had not undergone normal pubertal development and he displayed a height below the fifth percentile. Hormonal and radiological studies revealed the findings of severe anterior pituitary hormone deficiency and an atrophic pituitary gland. There had been no recent follow-ups with the patient or medical treatment since that time. In the current presentation, the patient, now 22 years of age, had attained normal height, yet he remained prepubertal and showed manifestations of delayed bone age and combined hypopituitarism. In addition, the patient's IGF-II levels were increased for his age.
Key Words: growth hormone, hypopituitarism, insulin-like growth factor-II


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