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HOME > Endocrinol Metab > Volume 23(6); 2008 > Article
Case Report A Case of MELAS Syndrome Manifested by Insulin-deficient Diabetes Mellitus.
Hee Seog Jeong, Ji Young Kang, Hyun Kim, Kyu Ho Lee, Dal Sic Lee, Guan Yong Choi, Tae Geun Oh, Hyen Jeong Jeon
Endocrinology and Metabolism 2008;23(6):444-449
DOI: https://doi.org/10.3803/jkes.2008.23.6.444
Published online: December 1, 2008
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Department of Internal Medicine, Chungbuk National University College of Medicine, Korea.
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Abstract

MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is characterized by stroke-like episodes before the age of 40, encephalopathy, seizures, dementia and lactic acidosis, and is caused by mutations in mitochondrial DNA. Diabetes mellitus and cardiac involvement are also frequently seen in MELAS syndrome. It is a classic mitochondrial disorder that shows a slow, chronic, progressive course, and presents with multiple organ involvement including the central nervous system, skeletal muscle, eye, cardiac muscle and gastrointestinal system.

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