Warning: fopen(/home/virtual/enm-kes/journal/upload/ip_log/ip_log_2024-12.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 100 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 101 Carnitine Metabolite as a Potential Circulating Biomarker for Sarcopenia in Men
Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > Endocrinol Metab > Ahead-of print > Article
Original Article Carnitine Metabolite as a Potential Circulating Biomarker for Sarcopenia in Men
Je Hyun Seo1*orcid , Jung-Min Koh2*orcid , Han Jin Cho3, Hanjun Kim3, Young‑Sun Lee3, Su Jung Kim4, Pil Whan Yoon5, Won Kim6, Sung Jin Bae7, Hong-Kyu Kim7, Hyun Ju Yoo4orcid , Seung Hun Lee2orcid

DOI: https://doi.org/10.3803/EnM.2024.2117 [Epub ahead of print]
Published online: November 28, 2024
  • 169 Views
  • 14 Download
  • 0 Crossref
  • 0 Scopus
1Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea
2Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
3Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea
4Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea
5Department of Orthopedic Surgery, Seoul Now Hospital, Anyang, Korea
6Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
7Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Corresponding author:  Hyun Ju Yoo, Tel: +82-2-3010-4029, Fax: +82-2-3010-8566, 
Email: yoohyunju@amc.seoul.kr
Seung Hun Lee, Tel: +82-2-3010-5666, Fax: +82-2-3010-6962, 
Email: hun0108@amc.seoul.kr
*These authors contributed equally to this work.
Received: 28 July 2024   • Revised: 21 September 2024   • Accepted: 7 October 2024
Full Article

Download PDF Download PDF

Abstract

Background
Sarcopenia, a multifactorial disorder involving metabolic disturbance, suggests potential for metabolite biomarkers. Carnitine (CN), essential for skeletal muscle energy metabolism, may be a candidate biomarker. We investigated whether CN metabolites are biomarkers for sarcopenia.
Methods
Associations between the CN metabolites identified from an animal model of sarcopenia and muscle cells and sarcopenia status were evaluated in men from an age-matched discovery (72 cases, 72 controls) and a validation (21 cases, 47 controls) cohort.
Results
An association between CN metabolites and sarcopenia showed in mouse and cell studies. In the discovery cohort, plasma C5-CN levels were lower in sarcopenic men (P=0.005). C5-CN levels in men tended to be associated with handgrip strength (HGS) (P=0.098) and were significantly associated with skeletal muscle mass (P=0.003). Each standard deviation increase in C5-CN levels reduced the odds of low muscle mass (odd ratio, 0.61; 95% confidence interval [CI], 0.42 to 0.89). The area under the receiver operating characteristic curve (AUROC) of CN score using a regression equation of C5-CN levels, for sarcopenia was 0.635 (95% CI, 0.544 to 0.726). In the discovery cohort, addition of CN score to HGS significantly improved AUROC from 0.646 (95% CI, 0.575 to 0.717; HGS only) to 0.727 (95% CI, 0.643 to 0.810; P=0.006; HGS+CN score). The improvement was confirmed in the validation cohort (AUROC=0.563; 95% CI, 0.470 to 0.656 for HGS; and AUROC=0.712; 95% CI, 0.569 to 0.855 for HGS+CN score; P=0.027).
Conclusion
C5-CN, indicative of low muscle mass, is a potential circulating biomarker for sarcopenia in men. Further studies are required to confirm these results and explore sarcopenia-related metabolomic changes.

Related articles
Endocrinol Metab : Endocrinology and Metabolism
© Korean Endocrine Society.
TOP