Endocrinol Metab > Volume 21(5); 2006 > Article
Journal of Korean Endocrine Society 2006;21(5):428-432.
DOI: https://doi.org/10.3803/jkes.2006.21.5.428    Published online October 1, 2006.
A Case of Primary Hypothyroidism with Anti-Triiodothyronine Autoantibody.
Jae Ho Park, Ji Hoon Ahn, Mi Hee Kang, Jong Chul Won, Kyung Wook Lee, Yeo Joo Kim, Ji Oh Mok, Hyeong Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo
1Department of Internal Medicine, SoonChunHyang University Hospital, Korea.
2Institute of Endocrinology Research, SoonChunHyang University Hospital, Korea.
Abstract
Antithyroid hormone autoantibodies can be present in the sera of patients with thyroid and non-thyroid disorders. Antithyroid hormone autoantibodies in a patient's serum interfere with radioimmunoassay of thyroid hormones. Clinically, this interference can result in discordance between the serum thyroid hormone levels and the clinical features of the patient, which can lead to misdiagnosis or inappropriate treatment. We experienced a woman who had primary hypothyroidism with unexpectedly high concentrations of serum total triiodothyronine (T(3)) and free T(3), and she had been treated for Graves' disease in the past. Through the use of a polyethylene glycol precipitation method, we detected the anti-triiodothyronine autoantibodies in her serum. We report on this case along with a review of the related literature.
Key Words: Anti-triiodothyronine autoantibody, Hypothyroidism


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