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- Case Report A Case of Malignant Insulinoma Metastasized to Liver after Partial Pancreatectomy due to Insulinoma 10 Years before.
- Yang Il Kang, Byung Hyuk Yang, Suk Chon, Seungjoon Oh, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Ju Hie Lee, Kwanpyo Koh
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Endocrinology and Metabolism 2006;21(1):68-73
DOI: https://doi.org/10.3803/jkes.2006.21.1.68
Published online: February 1, 2006
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2Department of Metabolism, College of Medicine, Kyung-Hee University, Seoul, Korea.
3Endocrine Research Institute, College of Medicine, Kyung-Hee University, Seoul, Korea.
4Department of Pathology, College of Medicine, Kyung-Hee University, Seoul, Korea.
5Department of Internal Medicine, Konyang University, Nonsan, Korea.
Abstract
Malignant insulinomas are very rare endocrine tumours with a variable clinical course. Here, a case of a malignant insulinoma, resected from the tail of the pancreas 10 years previously, which was found to have hepatic metastasis, is reported. A pancreatic mass, without evidence of metastasis, has been found using an abdominal CT scan and intra-operative ultrasonography 10 years previously. Recently, the patient has suffered from dizziness, sweating and an altered mentality. Hyperinsulinemia was diagnosed from the biochemical laboratory finding. An abdominal CT scan and intra-operative abdominal sonography showed multiple hepatic metastasis, without local recurrence in pancreas. Therefore, a partial hepatic segmentectomy was performed. Immunohistochemical staining of the postoperative specimen was strongly positive for insulin. The postoperative biochemical response was normalized, and the patient experienced no further hypoglycemic symptom.
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