A Case of Acromegaly with Gall Bladder Cancer.

Nam, Ji Sun; Kim, Chul Sik; Kong, Jee Hyun; Kim, Hai Jin; Park, Jin A; Park, Jong Suk; Ahn, Chul Woo; Lee, Se Joon; Cha, Bong Soo; Lim, Sung Kil; Kim, Kyung Rae; Lee, Hyun Chul

doi:2005.20.4.401

Endocrinol Metab > Volume 20(4); 2005 > Article

Case Report

Journal of Korean Endocrine Society 2005;20(4):401-406.
DOI: https://doi.org/10.3803/jkes.2005.20.4.401 Published online August 1, 2005.

A Case of Acromegaly with Gall Bladder Cancer.

Ji Sun Nam, Chul Sik Kim, Jee Hyun Kong, Hai Jin Kim, Jin A Park, Jong Suk Park, Chul Woo Ahn, Se Joon Lee, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee

Department of Internal Medicine, Yonsei University College of Medicine, Korea.

Abstract

Acromegaly is a systemic endocrine disorder due to an excessive release of growth hormone, which increases the serum levels of insulin-like growth factor-1(IGF-1). Elevated levels of these hormones are assumed to increase the incidence of malignant tumors in patients with acromegaly, due to by stimulating the growth and maturation of cells. In particular, IGF-1 is considered to be closely related with the development of colon polyps and colon cancers. Studies suggest that various malignant tumors, including thyroid cancer, brain tumor and renal cell carcinomas, are also more common in patients with acromegaly. Here, a case of gall bladder cancer in a patient with acromegaly, and the possible relationships between these two disorders, is reported.

Key Words: Acromegaly, Gall bladder cancer, Growth hormone, Insulin-like growth factor-1