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HOME > Endocrinol Metab > Volume 17(5); 2002 > Article
Case Report A Case of Papillary Thyroid Carcinoma Combined with Multiple Endocrine Neoplasia Type 2A.
Ja kyung Kim, Hae Won Chung, Hye Sun Seo, Dae Jung Kim, Sang Su Chung, Young Duk Song, Kuk Hwan Kwon, Yoon Mi Jin, Mi Kyung Lee, Sung Kil Lim, Il Jin Kim, Hio Chung Kang, Jae Hyun Park, Jae Gahb Park
Endocrinology and Metabolism 2002;17(5):730-738

Published online: October 1, 2002
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1Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Korea.
2Department of Surgery, National Health Insurance Corporation Ilsan Hospital, Korea.
3Department of Pathology, National Health Insurance Corporation Ilsan Hospital, Korea.
4Department of Internal Medicine, Yonsei University College of Medicine, Korea.
5Familial Cancer Clinic, National Cancer Center, Korea.

Multiple endocrine neoplasia (MEN) type 2A is a syndrome of medullary thyroid carcinomas, pheochromocytomas and parathyroid hyperplasia. The simultaneous occurrence of medullary, and papillary, thyroid carcinomas is rare because they are derived from, apparently, different germ layers, the former from the neuroectoderm and the latter from the endoderm. We report a case of a papillary thyroid carcinoma, combined with a medullary thyroid carcinoma, in a patient with MEN type 2A. Molecular genetic studies for screening a RET proto-oncogene mutation revealed a point mutation in codon 631 on chromosome 10, which is reported as highly uncommon in MEN type 2A.

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