Journal of Korean Endocrine Society 2001;16(1):123-129.
Published online February 1, 2001.
Renin-responsive Adrenal Adenoma with a Suspicious Abberant Adrenal Vein.
Ji Hyeon Ju, Woo Lee Jung, Jung Min Lee, Kun Ho Yoon, Bong Yun Cha, Ho Young Son, Dong Gu Kim, Eung Kook Kim, Byung Ki Choi
1Department of Internal Medicine, Catholic University Medical College, Korea.
2Department of General Surgery, Catholic University Medical College, Korea.
3Department of Radiology, Catholic University Medical College, Korea.
A renin- or angiotensin-II responsive aldosterone producing tumor is a rare cause of primary hyperaldosteronism. This tumor can be identified by tests that show that the aldosterone producing adrenal tumor is not fully autonomous. In other words partially it is responsible for the stimulation of aldosterone secretion that results aldosterone levels in an increase in serum in response to the upright posture and spironolactone treatment. Furthermore, the urinary 18-hydroxycortisol level is within the normal range. Because of different responses to surgical removal, the differential diagnosis of the causes of primary aldosteronism can't be overemphasized even for rare causes of primary aldosteronism such as unilateral nodular hyperplasia or a renin-responsible aldosterone producing tumor. We should consider renin or angiotensin-II responsive adrenal adenoma in the differential diagnosis of primary aldosteronism when biochemical data shows atypical results. Here we present the first case in Korea of a renin-responsive aldosterone producing adrenal adenoma which was fully accessible and was successfully treated by surgical removal. Also, sampling for aldosterone secretion just above the insertion site in the left renal vein before surgery showed a suspiciously abberant left adrenal vein drainage into the IVC, This was very helpful information during adrenal vein ligation in laparoscopic adrenalectomy.
Key Words: Renin-responsive adrenal adenoma, Abberant adrenal vein
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