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- Original Article Quantitative Changes of Apoprotein Levels in Non - Insulin Dependent Diabetics.
- Do Young Kang, Duk Kyu Kim
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Endocrinology and Metabolism 1994;10(2):105-114
Published online: November 6, 2019
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Abstract
The aim of this study was to evaluate the quantitative changes of apoprotein levels in non-insulin dependent diabetics.As the subjects of this study, 37 patients were selected among non-insulin dependent diabetics admitted to Dong-A University Hospital between March 1990 and February 1994. They were divided into two groups. One group(n=20) had the diabetic dyslipidemia(Group DD) and the other group(n=17) had no diabetic dyslipidemia(Group D). For the control, normal healthy persons(n=17) were studied.Plasma lipid and apoprotein levels of all the subjects were measured. The results were as follows;1) Apoprotein AI & AII levels were significantly decreased in Group DD compared with both Group D and Control, but there was no significant difference between Group D and Control.2) Apoprotein B levels were significantly decreased in both Group DD and Group D compared with Control, but there was no significant difference between Group DD and Group D. 3) Apoprotein CII levels were significantly increased in both Group DD and Group D compared with Control, but there was no significant difference between Group DD and Group D. 4) Apoprotein CIII levels were significantly increased in Group D compared with both Group DD and Control, but there was no significant difference between Group DD and Control. 5) Apoprotein E levels were not significantly different among three groups.These results suggest that NIDDM itself causes the level of apoprotein B to decrease and the level of apoprotein CII to increase, regardless of the associated diabetic dyslipidemia.
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