Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing

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Endocrinol Metab. 2021;36(2):468-468

Publication date (electronic) : 2021 March 24

doi : https://doi.org/10.3803/EnM.2021.202

Eun-Hee Cho ¹, Jae Woong Min ², Sun Shim Choi ², Hoon Sung Choi ¹, Sang-Wook Kim ¹

¹Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea

²Department of Medical Biotechnology, Institute of Bioscience and Biotechnology, Kangwon National University College of Biomedical Science, Chuncheon, Korea

Corresponding author: Sang-Wook Kim, Department of Internal Medicine, Kangwon National University School of Medicine, 156 Baengnyeong-ro, Chuncheon 24289, Korea, Tel: +82-33-258-9169, Fax: +82-33-258-2455, E-mail: sangwookkim@kangwon.ac.kr

This corrects the article "Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing" on page 296.

Endocrinol Metab 2017;32:296–301.

https://doi.org/10.3803/EnM.2017.32.2.296

In the published article, there was an incorrect amino acid change in Table 1. The “p.Ser383Pro” should be changed to “p.Ser383Leu.” The corrected table is shown below.

Table 1

Bioinformatics Analysis of GCK Mutations

We would like to apologize for any inconvenience or misunderstanding.

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Table 1

Bioinformatics Analysis of GCK Mutations

Case	GCK exon	PolyPhen-2/SIFT prediction	Amino acid change	DUET predicted stability changes (ΔΔG)	Reference
Family 1	2	1/Damaging	c.92T>C, p.Leu30Pro	−2.175 Kcal/mol (Destabilizing)	[6]
Family 2	9	1/Damaging	c.1151C>T, p.Ser383Leu	−0.465 Kcal/mol (Destabilizing)	[6]

Two mutations were predicted to be deleterious using online prediction tools. DUET is a web server that uses an integrated computational approach to study missense mutations in proteins; it is available at http://structure.bioc.cam.ac.uk/duet.

GCK, glucokinase; PolyPhen-2, polymorphism phenotyping v2.