Endocrinology and Metabolism

Review Article

February 24, 2021

The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging

Xin Gao, Yuto Yamazaki, Yuta Tezuka, et al.

Endocrinol Metab. 2021;36(1):12-21.

Primary aldosteronism (PA) is the most common cause of secondary hypertension, and is associated with an increased incidence of cardiovascular events. PA itself is clinically classified into the following two...

Review Article

February 24, 2021

Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists

Hun Jee Choe, Young Min Cho

Endocrinol Metab. 2021;36(1):22-29.

Glucagon-like peptide-1 (GLP-1) receptor agonists are efficacious glucose-lowering medications with salient benefits for body weight and cardiovascular events. This class of medications is now recommended as the top priority for...

Review Article

February 24, 2021

Best Achievements in Clinical Thyroidology in 2020

Eun Kyung Lee, Young Joo Park

Endocrinol Metab. 2021;36(1):30-35.

This review highlights the most interesting research in thyroidology conducted in 2020. The publications of interest discussed below dealt with the following topics: thyroid dysfunction, risk of thyroid cancer, molecular...

Review Article

February 24, 2021

Best Achievements in Translational and Basic Thyroidology in 2020

Sun Wook Cho, Young Joo Park

Endocrinol Metab. 2021;36(1):36-40.

This review discusses articles published in 2020 that presented noteworthy achievements in translational and basic thyroidology. Previously unresolved questions about thyroid hormone receptor actions and signaling mechanisms were answered using...

Review Article

February 24, 2021

Best Achievements in Clinical Medicine in Diabetes and Dyslipidemia in 2020

Eun-Jung Rhee, Mee-Kyung Kim, Won-Young Lee

Endocrinol Metab. 2021;36(1):41-50.

Over the last two decades, our understanding of diabetes and treatment strategies have evolved tremendously, from scientific, mechanistic, and human perspectives. The categories of anti-diabetic medications expanded from a few...

Review Article

February 24, 2021

Best Achievements in Pituitary and Adrenal Diseases in 2020

Chang Ho Ahn, Jung Hee Kim

Endocrinol Metab. 2021;36(1):51-56.

Significant progress in pituitary and adrenal diseases was made in 2020. This review presents major translational and clinical advances in research on pituitary and adrenal diseases, encompassing their epidemiology, pathogenesis,...

Original Article

Clinical Study

February 24, 2021

Romosozumab in Postmenopausal Korean Women with Osteoporosis: A Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study

Ki-Hyun Baek, Yoon-Sok Chung, Jung-Min Koh, et al.

Endocrinol Metab. 2021;36(1):60-69.

Background: This phase 3 study evaluated the efficacy and safety of 6-month treatment with romosozumab in Korean postmenopausal women with osteoporosis. Methods: Sixty-seven postmenopausal women with osteoporosis (bone mineral density [BMD]...

Original Article

Clinical Study

February 24, 2021

Effect of Teneligliptin versus Sulfonylurea on Major Adverse Cardiovascular Outcomes in People with Type 2 Diabetes Mellitus: A Real-World Study in Korea

Da Hea Seo, Kyoung Hwa Ha, So Hun Kim, et al.

Endocrinol Metab. 2021;36(1):70-80.

Background: Results regarding the cardiovascular (CV) effects of dipeptidyl peptidase-4 (DPP-4) inhibitors are inconsistent. This study aimed to assess the effects of teneligliptin, a DPP-4 inhibitor, on the risk of...

Original Article

Clinical Study

February 24, 2021

Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis

Cheng-Chun Yang, Yung Hsu, Jyun-Yan Liou

Endocrinol Metab. 2021;36(1):81-95.

Background: Ultrasound-guided minimally invasive procedures are widely used to treat thyroid diseases. The objective of this study was to assess the efficacy and safety of ethanol ablation (EA) in comparison...

Original Article

Clinical Study

February 24, 2021

Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer

Eun Jeong Ban, Daham Kim, Jin Kyong Kim, et al.

Endocrinol Metab. 2021;36(1):96-105.

Background: Several cancers show increased levels of lactate dehydrogenase A (LDHA), which are associated with cancer progression. However, it remains unclear whether LDHA levels are associated with papillary thyroid cancer...

Original Article

Clinical Study

February 24, 2021

Association of Vitamin D Deficiency with Diabetic Nephropathy

So-hyeon Hong, Young Bin Kim, Hoon Sung Choi, et al.

Endocrinol Metab. 2021;36(1):106-113.

Background: Low 25-hydroxyvitamin D (25OHD) levels are associated with the incidence of type 2 diabetes mellitus (T2DM). However, the association between 25OHD and metabolic health status or diabetic complications is...

Original Article

Clinical Study

February 24, 2021

Longitudinal Changes of High Molecular Weight Adiponectin are Associated with Postpartum Development of Type 2 Diabetes Mellitus in Patients with Gestational Diabetes Mellitus

Dong-Hwa Lee, Jung Ah Lim, Jung Hee Kim, et al.

Endocrinol Metab. 2021;36(1):114-122.

Background: The influence of serial changes of adipokines on maternal glucose metabolism from pregnancy to postpartum periods in women with previous gestational diabetes mellitus (pGDM) has not been thoroughly explored....

Original Article

Clinical Study

February 24, 2021

Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms

Chan Kwon Jung, Andrey Bychkov, Dong Eun Song, et al.

Endocrinol Metab. 2021;36(1):123-133.

Background: Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. The aim of this study was to determine whether pathologists could distinguish BRAF-like and RAS-like nuclear features...

Original Article

Clinical Study

February 24, 2021

Development of a Non-Invasive Liver Fibrosis Score Based on Transient Elastography for Risk Stratification in Patients with Type 2 Diabetes

Chi-Ho Lee, Wai-Kay Seto, Kelly Ieong, et al.

Endocrinol Metab. 2021;36(1):134-145.

Background: In non-alcoholic fatty liver disease (NAFLD), transient elastography (TE) is an accurate non-invasive method to identify patients at risk of advanced fibrosis (AF). We developed a diabetes-specific, non-invasive liver...

Original Article

Endocrine Research

February 24, 2021

Suppression of Fibrotic Reactions of Chitosan-Alginate Microcapsules Containing Porcine Islets by Dexamethasone Surface Coating

Min Jung Kim, Heon-Seok Park, Ji-Won Kim, et al.

Endocrinol Metab. 2021;36(1):146-156.

Background: The microencapsulation is an ideal solution to overcome immune rejection without immunosuppressive treatment. Poor biocompatibility and small molecular antigens secreted from encapsulated islets induce fibrosis infiltration. Therefore, the aims...

Original Article

Endocrine Research

February 24, 2021

Effects of Glucagon-Like Peptide-1 Analogue and Fibroblast Growth Factor 21 Combination on the Atherosclerosis-Related Process in a Type 2 Diabetes Mouse Model

Jin Hee Kim, Gha Young Lee, Hyo Jin Maeng, et al.

Endocrinol Metab. 2021;36(1):157-170.

Background: Glucagon-like peptide-1 (GLP-1) analogues regulate glucose homeostasis and have anti-inflammatory properties, but cause gastrointestinal side effects. The fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and...

Original Article

Endocrine Research

February 24, 2021

Mechanism of Lipid Accumulation through PAR2 Signaling in Diabetic Male Mice

Dae Hyun Kim, Ye Ra Kim, EunJin Bang, et al.

Endocrinol Metab. 2021;36(1):171-184.

Background: Protease-activated protein-2 (PAR2) has been reported to regulate hepatic insulin resistance condition in type 2 diabetes mice. However, the mechanism of lipid metabolism through PAR2 in obesity mice have...

Original Article

Endocrine Research

February 24, 2021

Danshen Extracts Prevents Obesity and Activates Mitochondrial Function in Brown Adipose Tissue

Yoon Hee Cho, Cheol Ryong Ku, Young-Suk Choi, et al.

Endocrinol Metab. 2021;36(1):185-195.

Background: Danshen has been widely used in oriental medicine to improve body function. The purpose of this study is to investigate the effect of water-soluble Danshen extract (DE) on weight...

Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress Min Jeong Choi, Saet-Byel Jung, Joon Young Chang, et al. Endocrinol Metab. 2021;36(1):1-11. Namgok Lecture 2020 Feb 24, 2021 PDF	The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging Xin Gao, Yuto Yamazaki, Yuta Tezuka, et al. Endocrinol Metab. 2021;36(1):12-21. Review Article Feb 24, 2021 PDF
Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists Hun Jee Choe, Young Min Cho Endocrinol Metab. 2021;36(1):22-29. Review Article Feb 24, 2021 PDF	Best Achievements in Clinical Thyroidology in 2020 Eun Kyung Lee, Young Joo Park Endocrinol Metab. 2021;36(1):30-35. Review Article Feb 24, 2021 PDF
Best Achievements in Translational and Basic Thyroidology in 2020 Sun Wook Cho, Young Joo Park Endocrinol Metab. 2021;36(1):36-40. Review Article Feb 24, 2021 PDF	Best Achievements in Clinical Medicine in Diabetes and Dyslipidemia in 2020 Eun-Jung Rhee, Mee-Kyung Kim, Won-Young Lee Endocrinol Metab. 2021;36(1):41-50. Review Article Feb 24, 2021 PDF
Best Achievements in Pituitary and Adrenal Diseases in 2020 Chang Ho Ahn, Jung Hee Kim Endocrinol Metab. 2021;36(1):51-56. Review Article Feb 24, 2021 PDF	Unlocking the Therapeutic Potential of Glucagon-Like Peptide-1 Analogue and Fibroblast Growth Factor 21 Combination for the Pathogenesis of Atherosclerosis in Type 2 Diabetes Jang Won Son Endocrinol Metab. 2021;36(1):57-59. Editorial Feb 24, 2021 PDF
Romosozumab in Postmenopausal Korean Women with Osteoporosis: A Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study Ki-Hyun Baek, Yoon-Sok Chung, Jung-Min Koh, et al. Endocrinol Metab. 2021;36(1):60-69. Original Article Clinical Study Feb 24, 2021 PDF	Effect of Teneligliptin versus Sulfonylurea on Major Adverse Cardiovascular Outcomes in People with Type 2 Diabetes Mellitus: A Real-World Study in Korea Da Hea Seo, Kyoung Hwa Ha, So Hun Kim, et al. Endocrinol Metab. 2021;36(1):70-80. Original Article Clinical Study Feb 24, 2021 PDF
Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis Cheng-Chun Yang, Yung Hsu, Jyun-Yan Liou Endocrinol Metab. 2021;36(1):81-95. Original Article Clinical Study Feb 24, 2021 PDF	Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer Eun Jeong Ban, Daham Kim, Jin Kyong Kim, et al. Endocrinol Metab. 2021;36(1):96-105. Original Article Clinical Study Feb 24, 2021 PDF
Association of Vitamin D Deficiency with Diabetic Nephropathy So-hyeon Hong, Young Bin Kim, Hoon Sung Choi, et al. Endocrinol Metab. 2021;36(1):106-113. Original Article Clinical Study Feb 24, 2021 PDF	Longitudinal Changes of High Molecular Weight Adiponectin are Associated with Postpartum Development of Type 2 Diabetes Mellitus in Patients with Gestational Diabetes Mellitus Dong-Hwa Lee, Jung Ah Lim, Jung Hee Kim, et al. Endocrinol Metab. 2021;36(1):114-122. Original Article Clinical Study Feb 24, 2021 PDF
Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms Chan Kwon Jung, Andrey Bychkov, Dong Eun Song, et al. Endocrinol Metab. 2021;36(1):123-133. Original Article Clinical Study Feb 24, 2021 PDF	Development of a Non-Invasive Liver Fibrosis Score Based on Transient Elastography for Risk Stratification in Patients with Type 2 Diabetes Chi-Ho Lee, Wai-Kay Seto, Kelly Ieong, et al. Endocrinol Metab. 2021;36(1):134-145. Original Article Clinical Study Feb 24, 2021 PDF
Suppression of Fibrotic Reactions of Chitosan-Alginate Microcapsules Containing Porcine Islets by Dexamethasone Surface Coating Min Jung Kim, Heon-Seok Park, Ji-Won Kim, et al. Endocrinol Metab. 2021;36(1):146-156. Original Article Endocrine Research Feb 24, 2021 PDF	Effects of Glucagon-Like Peptide-1 Analogue and Fibroblast Growth Factor 21 Combination on the Atherosclerosis-Related Process in a Type 2 Diabetes Mouse Model Jin Hee Kim, Gha Young Lee, Hyo Jin Maeng, et al. Endocrinol Metab. 2021;36(1):157-170. Original Article Endocrine Research Feb 24, 2021 PDF
Mechanism of Lipid Accumulation through PAR2 Signaling in Diabetic Male Mice Dae Hyun Kim, Ye Ra Kim, EunJin Bang, et al. Endocrinol Metab. 2021;36(1):171-184. Original Article Endocrine Research Feb 24, 2021 PDF	Danshen Extracts Prevents Obesity and Activates Mitochondrial Function in Brown Adipose Tissue Yoon Hee Cho, Cheol Ryong Ku, Young-Suk Choi, et al. Endocrinol Metab. 2021;36(1):185-195. Original Article Endocrine Research Feb 24, 2021 PDF
Overweight and Obesity are Risk Factors for Coronavirus Disease 2019: A Propensity Score-Matched Case-Control Study Wonjun Ji, Rugyeom Lee, Kyungmin Huh, et al. Endocrinol Metab. 2021;36(1):196-200. Brief Report Feb 24, 2021 PDF	Anaplastic Thyroid Carcinoma with Initial Ultrasonography Features Mimicking Subacute Thyroiditis Meihua Jin, Tae Yong Kim Endocrinol Metab. 2021;36(1):201-202. Image of Interest Feb 24, 2021 PDF
Association of Hyperparathyroidism and Papillary Thyroid Cancer: A Multicenter Retrospective Study (Endocrinol Metab 2020;35:925-32, Chaiho Jeong et al.) Burcu Candemir, Coşkun Meriç Endocrinol Metab. 2021;36(1):203-204. Letter Feb 24, 2021 PDF	Association of Hyperparathyroidism and Papillary Thyroid Cancer: A Multicenter Retrospective Study (Endocrinol Metab 2020;35:925-32, Chaiho Jeong et al.) Chaiho Jeong, Jeonghoon Ha, Moo Il Kang Endocrinol Metab. 2021;36(1):205-206. Response Feb 24, 2021 PDF

3,854	Tumor Cells and Cancer-Associated Fibroblasts: A Synergistic Crosstalk to Promote Thyroid Cancer
3,065	WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System
3,725	Relationships between Thigh and Waist Circumference, Hemoglobin Glycation Index, and Carotid Plaque in Patients with Type 2 Diabetes
2,400	Current National and International Guidelines for the Management of Male Hypogonadism: Helping Clinicians to Navigate Variation in Diagnostic Criteria and Treatment Recommendations
4,282	Encountering COVID-19 as Endocrinologists

Cited By 25	Long-Term Outcomes Following Thermal Ablation of Benign Thyroid Nodules as an Alternative to Surgery: The Importance of Controlling Regrowth
Cited By 18	Graves' Disease: Can It Be Cured?
Cited By 16	Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective
Cited By 13	Triglyceride Glucose Index Is Superior to the Homeostasis Model Assessment of Insulin Resistance for Predicting Nonalcoholic Fatty Liver Disease in Korean Adults
Cited By 13	Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond