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Original Article
- Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder
- Haijie Yang, Sung-Oh Huh, Jae Seung Hong
- Endocrinol Metab. 2015;30(1):98-104. Published online March 27, 2015
- DOI: https://doi.org/10.3803/EnM.2015.30.1.98
- 3,963 View
- 36 Download
- 9 Web of Science
- 10 Crossref
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Abstract
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PubReader Background Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. This study evaluated the effect of methyl-6-(phenylethynyl)-pyridine (MPEP), an antagonist of the mGluR5 metabotropic glutamate receptor, on memory enhancement in the BTBR T+tf/J (BTBR) mouse strain, which has been recognized as a model of ASD.
Methods The pharmacological effects of MPEP on memory and motor coordination were assessed using the Morris water maze and rotarod tests in BTBR and C57BL/6J (B6) mice. Furthermore, we performed morphological analyses of cerebellar foliation in BTBR and B6 mice using hematoxylin and eosin staining.
Results MPEP-treated BTBR mice exhibited improved learning and memory in the Morris water maze test. MPEP administration also improved motor coordination in the rotarod test. However, no significant difference was observed regarding the numbers of Purkinje cells in the cerebella of BTBR versus normal B6 mice.
Conclusion This study suggests that the mGluR5 antagonist MPEP has the potential to ameliorate learning and memory dysfunction and impaired motor coordination in BTBR mice. These results further suggest that the BTBR mouse model may be useful in pharmacological studies investigating drugs that could potentially alleviate cognitive dysfunction in ASD.
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Citations
Citations to this article as recorded by
- Postweaning social isolation and autism-like phenotype: A biochemical and behavioral comparative analysis
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Behavioural Brain Research.2022; 428: 113891. CrossRef - Postweaning Social Isolation and Autism-Like Phenotype: A Biochemical and Behavioral Comparative Analysis
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SSRN Electronic Journal .2021;[Epub] CrossRef - Abnormal Cerebellar Development Is Involved in Dystonia-Like Behaviors and Motor Dysfunction of Autistic BTBR Mice
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Frontiers in Neuroscience.2018;[Epub] CrossRef - The BTBR mouse model of idiopathic autism – Current view on mechanisms
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Expert Opinion on Drug Discovery.2017; 12(12): 1187. CrossRef - Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism
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PLOS ONE.2017; 12(6): e0179409. CrossRef - Bridging Autism Spectrum Disorders and Schizophrenia through inflammation and biomarkers - pre-clinical and clinical investigations
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Behavioural Pharmacology.2015; 26(6): 522. CrossRef
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