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2 "Diphosphonates"
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Calcium & Bone Metabolism
Review and Update of the Risk Factors and Prevention of Antiresorptive-Related Osteonecrosis of the Jaw
Ha Young Kim
Endocrinol Metab. 2021;36(5):917-927.   Published online October 21, 2021
DOI: https://doi.org/10.3803/EnM.2021.1170
  • 4,488 View
  • 268 Download
  • 8 Web of Science
  • 11 Crossref
AbstractAbstract PDFPubReader   ePub   
Antiresorptive-related osteonecrosis of the jaw (ARONJ) is a rare but serious adverse event of bisphosphonate or denosumab administration; it is associated with severe pain and a deteriorated quality of life. Since its first report in 2003, there have been many studies on its definition, epidemiology, pathophysiology, diagnosis, and treatment. Nevertheless, the epidemiology and mechanisms underlying this condition have not yet been fully delineated and several risk factors are known. Moreover, as there is no effective treatment currently available for osteonecrosis of the jaw, prevention is essential. Furthermore, close cooperation between prescribing physicians and dentists is important. The aim of this review was to provide up-to-date information regarding the risk factors and prevention of ARONJ from a physician’s perspective.

Citations

Citations to this article as recorded by  
  • Risk factors for dental findings of the development of medication-related osteonecrosis of the jaw: Investigation of 3734 teeth in cancer patients receiving high dose antiresorptive agents
    Mitsunobu Otsuru, Yoshinari Fujiki, Sakiko Soutome, Norio Nakamura, Taro Miyoshi, Tomofumi Naruse, Mizuho Ohnuma, Yuka Hotokezaka, Satoshi Rokutanda, Masahiro Umeda
    Journal of Dental Sciences.2024; 19(1): 203.     CrossRef
  • Editorial: Immunological processes in maxillofacial bone pathology
    Matthias Tröltzsch
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Polysacharide of Agaricus blazei gel mitigates bone necrosis in model of the jaws related to bisphosphonate via Wnt signaling
    Vanessa Costa de Sousa, Fátima Regina Nunes Sousa, Raquel Felipe Vasconcelos, Gisele Angelino Barreto, Conceição S. Martins, Nilson Romero Dias, Sislana Costa, Maria Jennifer Chaves Bernardino, George de Almeida Silva, Nadine Linhares, Delane Gondim, Mirn
    Scientific Reports.2024;[Epub]     CrossRef
  • Prevention of medication-related osteonecrosis of the jaw after tooth extraction by local administration of antibiotics and atelocollagen sponge: A preliminary study
    Natsumi Nakamura, Sakiko Soutome, Akira Imakiire, Satoshi Rokutanda, Seigo Ohba, Shunsuke Sawada, Yuka Kojima, Yuki Sakamoto, Yoshiko Yamamura, Madoka Funahara, Mitsunobu Otsuru, Masahiro Umeda
    Journal of Dental Sciences.2024;[Epub]     CrossRef
  • When and how to stop denosumab therapy in a patient with osteoporosis
    Eirena L. Goulden, Rachel K. Crowley
    Clinical Endocrinology.2023; 98(5): 649.     CrossRef
  • Clinical and Histopathological Aspects of MRONJ in Cancer Patients
    George Adrian Ciobanu, Laurențiu Mogoantă, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Ionela Elisabeta Staicu, Cristina Maria Munteanu, Mircea Ionuț Gheorghiță, Răzvan Mercuț, Elena Claudia Sin, Sanda Mihaela Popescu
    Journal of Clinical Medicine.2023; 12(10): 3383.     CrossRef
  • Bisphosphonates and osteonecrosis of the jaws: Clinical and forensic aspects
    Diana Nogueira, Inês Morais Caldas, Ricardo Jorge Dinis-Oliveira
    Archives of Oral Biology.2023; 155: 105792.     CrossRef
  • Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid
    George Adrian Ciobanu, Laurențiu Mogoantă, Sanda Mihaela Popescu, Mihaela Ionescu, Cristina Maria Munteanu, Ionela Elisabeta Staicu, Răzvan Mercuț, Cristian Corneliu Georgescu, Monica Scrieciu, Daniel Vlad, Adrian Camen
    International Journal of Molecular Sciences.2023; 24(18): 14345.     CrossRef
  • Analysis of the Degree of Information of Dental Surgeons about Antiresorptive Drugs According to the Time Since Graduation in Dentistry
    Flávia Godinho Costa Wanderley Rocha, Roberto Paulo Correia de Araújo
    Pesquisa Brasileira em Odontopediatria e Clínica Integrada.2023;[Epub]     CrossRef
  • Safety and Efficacy of Pamidronate in Neonatal Hypercalcemia Caused by Subcutaneous Fat Necrosis: A Case Report
    Stefano Martinelli, Marco Pitea, Italo Francesco Gatelli, Tara Raouf, Graziano Barera, Ottavio Vitelli
    Frontiers in Pediatrics.2022;[Epub]     CrossRef
  • Zoledronic acid for osteoporosis and associated low-energy fractures
    S. S. Rodionova, A. F. Kolondaev, A. N. Torgashin, I. A. Solomyannik
    Meditsinskiy sovet = Medical Council.2022; (21): 163.     CrossRef
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Bone Metabolism
Long-Term Treatment of Postmenopausal Osteoporosis
Jacques P. Brown
Endocrinol Metab. 2021;36(3):544-552.   Published online June 22, 2021
DOI: https://doi.org/10.3803/EnM.2021.301
  • 15,048 View
  • 942 Download
  • 38 Web of Science
  • 37 Crossref
AbstractAbstract PDFPubReader   ePub   
Osteoporosis is an incurable chronic condition, like heart disease, diabetes, or hypertension. A large gap currently exists in the primary prevention of fractures, and studies show that an estimated 80% to 90% of adults do not receive appropriate osteoporosis management even in the secondary prevention setting. Case finding strategies have been developed and effective pharmacological interventions are available. This publication addresses how best to use the pharmacological options available for postmenopausal osteoporosis to provide lifelong fracture protection in patients at high and very high risk of fracture. The benefit of osteoporosis therapies far outweighs the rare risks.

Citations

Citations to this article as recorded by  
  • Effects of stepwise administration of osteoprotegerin and parathyroid hormone-related peptide DNA vectors on bone formation in ovariectomized rat model
    Ye Ji Eom, Jang-Woon Kim, Yeri Alice Rim, Jooyoung Lim, Se In Jung, Ji Hyeon Ju
    Scientific Reports.2024;[Epub]     CrossRef
  • Glycolithocholic acid increases the frequency of circulating Tregs through constitutive androstane receptor to alleviate postmenopausal osteoporosis
    Xiaoyu Cai, Zhi Li, Yao Yao, Yongquan Zheng, Meng Zhang, Yiqing Ye
    Biochemical Pharmacology.2024; 219: 115951.     CrossRef
  • Cucumber seed polypeptides regulate RANKL-induced osteoclastogenesis through OPG/RANKL/RANK and NF-κB
    Tao Yu, Xiao Liu, Meng Jiang, Yuanyue Li, Heng Su, Ben Niu
    In Vitro Cellular & Developmental Biology - Animal.2024; 60(1): 54.     CrossRef
  • Eupatilin ameliorates postmenopausal osteoporosis via elevating microRNA‐211‐5p and repressing JAK2/STAT3 pathway
    Liu Hong, Chao Yang
    Environmental Toxicology.2024; 39(4): 2218.     CrossRef
  • Strontium-Doped Mesoporous Bioactive Glass-Loading Bisphosphonates Inhibit Osteoclast Differentiation and Prevent Osteoporosis in Ovariectomized Mice
    Zhi Zhou, Shicheng Huo, Zhanchun Li
    Coatings.2024; 14(1): 97.     CrossRef
  • A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis
    Fei Zhang, Chen Liu, Zhiyong Chen, Chengyi Zhao
    Cell Biology International.2024; 48(4): 541.     CrossRef
  • Research Progress of Zoledronic Acid in the Treatment of Osteoarthritis
    保成 刘
    Advances in Clinical Medicine.2024; 14(02): 2821.     CrossRef
  • A novel mechanism of Vildagliptin in regulating bone metabolism and mitigating osteoporosis
    Jinwen He, Dacheng Zhao, Bo Peng, Xingwen Wang, Shenghong Wang, Xiaobing Zhao, Peng Xu, Bin Geng, Yayi Xia
    International Immunopharmacology.2024; 130: 111671.     CrossRef
  • Positive benefit-risk ratio of Psoraleae Fructus: Comprehensive safety assessment and osteogenic effects in rats
    Zhuo Shi, Jin-chao Pan, Yi Ru, Ning-ning Shen, Yu-fu Liu, Cheng Zhang, Xiang-jun Wu, Fang-yang Li, Jia-lu Cui, Chun-qi Yang, Jun-ling Yang, Mao-xing Li, Cheng-rong Xiao, Zeng-chun Ma, Chuan Li, Yu-guang Wang, Yue Gao
    Journal of Ethnopharmacology.2024; 326: 117967.     CrossRef
  • Function-oriented mechanism discovery of coumarins from Psoralea corylifolia L. in the treatment of ovariectomy-induced osteoporosis based on multi-omics analysis
    Qianyi Wei, Yongrong Zhou, Zhengtao Hu, Ye Shi, Qing Ning, Keyun Ren, Xinyu Guo, Ronglin Zhong, Zhi Xia, Yinghao Yin, Yongxin Hu, Yingjie Wei, Ziqi Shi
    Journal of Ethnopharmacology.2024; 329: 118130.     CrossRef
  • Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis
    Ning Cao, Zhangxuan Shou, Yi Xiao, Puqing Liu
    Current Drug Targets.2024; 25(2): 135.     CrossRef
  • Enhanced oral bioavailability of levormeloxifene and raloxifene by nanoemulsion: simultaneous bioanalysis using liquid chromatography-tandem mass spectrometry
    Divya Chauhan, Debalina Maity, Pavan K Yadav, Sachin Vishwakarma, Arun Agarwal, Manish K Chourasia, Jiaur R Gayen
    Nanomedicine.2024;[Epub]     CrossRef
  • Changes in Testing and Treatment Methods in Osteoporosis Care
    Takashi Nagai, Koji Ishikawa, Koki Tsuchiya, Soji Tani, Yusuke Dodo, Yusuke Oshita, Keizo Sakamoto, Nobuyuki Kawate, Yoshifumi Kudo, Deepak Kumar Khajuria
    Journal of Osteoporosis.2024; 2024: 1.     CrossRef
  • CircRNA hsa_circ_0006859 inhibits the osteogenic differentiation of BMSCs and aggravates osteoporosis by targeting miR-642b-5p/miR-483-3p and upregulating EFNA2/DOCK3
    Peng Yin, Yuan Xue
    International Immunopharmacology.2023; 116: 109844.     CrossRef
  • Resveratrol induces proliferation and differentiation of mouse pre-osteoblast MC3T3-E1 by promoting autophagy
    Weiye Cai, Bin Sun, Chao Song, Fei Liu, Zhengliang Wu, Zongchao Liu
    BMC Complementary Medicine and Therapies.2023;[Epub]     CrossRef
  • Oridonin Attenuates Thioacetamide-Induced Osteoclastogenesis Through MAPK/NF-κB Pathway and Thioacetamide-Inhibited Osteoblastogenesis Through BMP-2/RUNX2 Pathway
    XiaoLi Jin, Jia Xu, Fanfan Yang, Jin Chen, Feng Luo, Bin Xu, Jian Xu
    Calcified Tissue International.2023; 112(6): 704.     CrossRef
  • Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review
    Alina Hanga-Farcaș, Florina Miere (Groza), Gabriela Adriana Filip, Simona Clichici, Luminita Fritea, Laura Grațiela Vicaș, Eleonora Marian, Annamaria Pallag, Tunde Jurca, Sanda Monica Filip, Mariana Eugenia Muresan
    Plants.2023; 12(10): 2055.     CrossRef
  • Screening of superior anti‐osteoporotic flavonoids from Epimedii Folium with dual effects of reversing iron overload and promoting osteogenesis
    Jun Jiang, Jinjin He, Shichang Xiao, Jiayi Shenyuan, Tong Chen, Dan Pei
    Biomedical Chromatography.2023;[Epub]     CrossRef
  • Study on the Effect of Bushen Zhuanggu Tablet Combined with Conventional Regimen on Bone Mineral Density Improvement, Functional Recovery and Fracture Risk Prevention in Patients with Postmenopausal Osteoporosis
    Tianliang Chen, Guilan Li, Yongtao Xu, Min Tang
    Computational and Mathematical Methods in Medicine.2023; 2023: 1.     CrossRef
  • Circ_0001825 promotes osteogenic differentiation in human-derived mesenchymal stem cells via miR-1270/SMAD5 axis
    Changjun Zheng, Lingzhi Ding, Ziming Xiang, Mingxuan Feng, Fujiang Zhao, Zhaoxin Zhou, Chang She
    Journal of Orthopaedic Surgery and Research.2023;[Epub]     CrossRef
  • Identification of ROCK1 as a novel biomarker for postmenopausal osteoporosis and pan-cancer analysis
    Bowen Lai, Heng Jiang, Yuan Gao, Xuhui Zhou
    Aging.2023; 15(17): 8873.     CrossRef
  • The Mechanotransduction Signaling Pathways in the Regulation of Osteogenesis
    Zhaoshuo Liu, Qilin Wang, Junyou Zhang, Sihan Qi, Yingying Duan, Chunyan Li
    International Journal of Molecular Sciences.2023; 24(18): 14326.     CrossRef
  • Decoding the mechanism of Eleutheroside E in treating osteoporosis via network pharmacological analysis and molecular docking of osteoclast-related genes and gut microbiota
    Tianyu Zhou, Yilin Zhou, Dongdong Ge, Youhong Xie, Jiangyan Wang, Lin Tang, Qunwei Dong, Ping Sun
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Epigallocatechin gallate alleviates osteoporosis by regulating the gut microbiota and serum metabolites in rats
    Xuebing Han, Yifeng Fu, Keyu Wang, Siying Li, Chang Jiang, Shuangshuang Wang, Zheng Wang, Gang Liu, Siwang Hu
    Food & Function.2023; 14(23): 10564.     CrossRef
  • The Molecular Role of Polyamines in Age-Related Diseases: An Update
    Guadalupe Elizabeth Jimenez Gutierrez, Fabiola V. Borbolla Jiménez, Luis G. Muñoz, Yessica Sarai Tapia Guerrero, Nadia Mireya Murillo Melo, José Melesio Cristóbal-Luna, Norberto Leyva Garcia, Joaquín Cordero-Martínez, Jonathan J. Magaña
    International Journal of Molecular Sciences.2023; 24(22): 16469.     CrossRef
  • Pueraria lobata-derived exosome-like nanovesicles alleviate osteoporosis by enhacning autophagy
    Weiqiang Zhan, Mingzhu Deng, Xinqia Huang, Dong Xie, Xiang Gao, Jiaxian Chen, Zhen Shi, Jiaxu Lu, Hao Lin, Peng Li
    Journal of Controlled Release.2023; 364: 644.     CrossRef
  • Based on network pharmacology and molecular docking to explore the molecular mechanism of Ginseng and Astragalus decoction against postmenopausal osteoporosis
    Wei Fan, Zong-Zhe Jiang, Sheng-Rong Wan
    Medicine.2023; 102(46): e35887.     CrossRef
  • Network pharmacology-based pharmacological mechanism prediction of Lycii Fructus against postmenopausal osteoporosis
    Jianbo Wang, Yi Wang, Leyan Li, Shuiqi Cai, Dandan Mao, Hongkan Lou, Jian Zhao
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  • Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates
    Yun Sun Lee, So Jeong Park, Jin Young Lee, Eunah Choi, Beom-Jun Kim
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  • ED-71 inhibited osteoclastogenesis by enhancing EphrinB2–EphB4 signaling between osteoclasts and osteoblasts in osteoporosis
    Yuan Zhang, Yuying Kou, Panpan Yang, Xing Rong, Rong Tang, Hongrui Liu, Minqi Li
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  • Effects of Muscles on Bone Metabolism—with a Focus on Myokines
    Beom-Jun Kim
    Annals of Geriatric Medicine and Research.2022; 26(2): 63.     CrossRef
  • Evaluation of the tolerability of zoledronic acid preparations for parenteral administration
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    Meditsinskiy sovet = Medical Council.2022; (11): 96.     CrossRef
  • Impact of Alendronate Sodium plus Elcatonin on Postoperative Bone Pain in Patients with Osteoporotic Fractures
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    Clinical Biochemistry.2022; 109-110: 1.     CrossRef
  • Study on the influence of balloon dilation mode on the intravertebral cleft of osteoporotic fracture
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  • An Acid-Sensitive Bone Targeting Delivery System Carrying Acacetin Prevents Osteoporosis in Ovariectomized Mice
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  • Changes in Serum Dickkopf-1, RANK Ligand, Osteoprotegerin, and Bone Mineral Density after Allogeneic Hematopoietic Stem Cell Transplantation Treatment
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    Endocrinology and Metabolism.2021; 36(6): 1211.     CrossRef
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Endocrinol Metab : Endocrinology and Metabolism