Endocrinology and Metabolism

Original Articles

Endocrine Research
Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice: Qi Duan, Tingting Wang, Na Zhang, Vern Perera, Xue Liang, Iruni Roshanie Abeysekera, Xiaomei Yao; Endocrinol Metab. 2016;31(1):174-184. Published online March 16, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.1.174

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Background

Increased oxidative stress has been suggested as one of the underlying mechanisms in iodide excess-induced thyroid disease. Metallothioneins (MTs) are regarded as scavengers of reactive oxygen species (ROS) in oxidative stress. Our aim is to investigate the effects of propylthiouracil (PTU), a thyroid peroxidase inhibitor, perchlorate (KClO₄), a competitive inhibitor of iodide transport, and thyroid stimulating hormone (TSH) on mitochondrial superoxide production instigated by high concentrations of iodide in the thyroids of MT-I/II knockout (MT-I/II KO) mice.

Methods

Eight-week-old 129S7/SvEvBrd-Mt1^tm1Bri Mt2^tm1Bri/J (MT-I/II KO) mice and background-matched wild type (WT) mice were used.

Results

By using a mitochondrial superoxide indicator (MitoSOX Red), lactate dehydrogenase (LDH) release, and methyl thiazolyl tetrazolium (MTT) assay, we demonstrated that the decreased relative viability and increased LDH release and mitochondrial superoxide production induced by potassium iodide (100 µM) can be relieved by 300 µM PTU, 30 µM KClO₄, or 10 U/L TSH in the thyroid cell suspensions of both MT-I/II KO and WT mice (P<0.05). Compared to the WT mice, a significant decrease in the relative viability along with a significant increase in LDH release and mitochondrial superoxide production were detected in MT-I/II KO mice(P<0.05).

Conclusion

We concluded that PTU, KClO₄, or TSH relieved the mitochondrial oxidative stress induced by high concentrations of iodide in the thyroids of both MT-I/II KO and WT mice. MT-I/II showed antioxidant effects against high concentrations of iodide-induced mitochondrial superoxide production in the thyroid.

Citations

Citations to this article as recorded by

Exposure to Polybrominated Diphenyl Ethers and Thyroid Disease: a Systematic Review and Meta-analysis of Epidemiological Studies
Yuxin Lin, Lili Yang, Manling Xie, Haibo Li, Qian Zhang
Current Epidemiology Reports.2024; 11(1): 20. CrossRef
The reversal of drug resistance by two‐dimensional titanium carbide Ti2C (2D Ti2C) in non‐small‐cell lung cancer via the depletion of intracellular antioxidant reserves
Yue Zhu, Baiyan Sui, Xin Liu, Jiao Sun
Thoracic Cancer.2021; 12(24): 3340. CrossRef
Thyroid function alterations attributed to high iodide supplementation in maternal rats and their offspring
Xue Liang, Yanni Feng, Laixiang Lin, Iruni Roshanie Abeysekera, Umar Iqbal, Tingting Wang, Ying Wang, Xiaomei Yao
Journal of Trace Elements in Medicine and Biology.2018; 47: 89. CrossRef
Ecotoxicological assessment of perchlorate using in vitro and in vivo assays
Rosa Acevedo-Barrios, Consuelo Sabater-Marco, Jesus Olivero-Verbel
Environmental Science and Pollution Research.2018; 25(14): 13697. CrossRef
Isolated domains of recombinant human apo-metallothionein 1A are folded at neutral pH: a denaturant and heat-induced unfolding study using ESI-MS
Gordon W. Irvine, Natalie Korkola, Martin J. Stillman
Bioscience Reports.2018;[Epub] CrossRef
Reappraisal of metallothionein: Clinical implications for patients with diabetes mellitus
Yongsoo Park, Jian Zhang, Lu Cai
Journal of Diabetes.2018; 10(3): 213. CrossRef
Mammalian Metallothionein-2A and Oxidative Stress
Xue-Bin Ling, Hong-Wei Wei, Jun Wang, Yue-Qiong Kong, Yu-You Wu, Jun-Li Guo, Tian-Fa Li, Ji-Ke Li
International Journal of Molecular Sciences.2016; 17(9): 1483. CrossRef

Thyroid
Diagnostic Whole-Body Scan May Not Be Necessary for Intermediate-Risk Patients with Differentiated Thyroid Cancer after Low-Dose (30 mCi) Radioactive Iodide Ablation: Eon Ju Jeon, Eui Dal Jung; Endocrinol Metab. 2014;29(1):33-39. Published online March 14, 2014; DOI: https://doi.org/10.3803/EnM.2014.29.1.33

3,932 View
32 Download
10 Web of Science
9 Crossref

Abstract PDF PubReader

Background

A diagnostic whole-body scan (WBS) is recommended 6 to 12 months after total thyroidectomy and radioactive iodide ablation in intermediate- or high-risk patients with differentiated thyroid cancer (DTC). The aim of this study was to evaluate the necessity of a diagnostic WBS after radioactive iodide ablation in intermediate-risk patients with DTC.

Methods

A total of 438 subjects were included in the study: 183 low-risk subjects and 255 intermediate-risk subjects according to the American Thyroid Association guideline. All subjects diagnosed with DTC received 1,100 MBq (30 mCi) activity of radioiodine (I-131) following total thyroidectomy. On follow-up, all subjects underwent a diagnostic I-131 WBS after thyroid hormone withdrawal.

Results

After initial radioactive iodide ablation, 95.1% of low-risk patients and 91.4% of intermediate-risk patients showed no uptake on diagnostic WBS (P=0.135). Intermediate-risk patients with stimulated thyroglobulin (Tg) levels higher than 2.0 ng/mL showed a greater rate of radioactive iodine uptake on diagnostic WBS. Four intermediate-risk patients showed recurrence during the 16 to 80 months follow-up period. Three of the four patients with recurrence showed no uptake on diagnostic WBS and had a stimulated Tg level less than 2.0 ng/mL.

Conclusion

A diagnostic I-131 WBS after radioactive iodide ablation in intermediate-risk patients with DTC may not be necessary. A large prospective study is necessary to determine the necessity of diagnostic WBS in intermediate-risk patients with DTC.

Citations

Citations to this article as recorded by

Long-Term Prognostic Value of the Response to Therapy Assessed by Laboratory and Imaging Findings in Patients with Differentiated Thyroid Cancer
Michele Klain, Emilia Zampella, Leandra Piscopo, Fabio Volpe, Mariarosaria Manganelli, Stefania Masone, Leonardo Pace, Domenico Salvatore, Martin Schlumberger, Alberto Cuocolo
Cancers.2021; 13(17): 4338. CrossRef
Lack of Efficacy of Radioiodine Remnant Ablation for Papillary Thyroid Microcarcinoma: Verification Using Inverse Probability of Treatment Weighting
Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Suyeon Park, Mijin Kim, Tae Yong Kim, Minkyu Han, Dong Eun Song, Tae-Yon Sung, Jong Ho Yoon, Suck Joon Hong, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
Annals of Surgical Oncology.2017; 24(9): 2596. CrossRef
Evaluation of 131I scintigraphy and stimulated thyroglobulin levels in the follow up of patients with DTC: a retrospective analysis of 1420 patients
Jose Manuel Gonzalez Carvalho, Dennis Görlich, Otmar Schober, Christian Wenning, Burkhard Riemann, Frederik Anton Verburg, Alexis Vrachimis
European Journal of Nuclear Medicine and Molecular Imaging.2017; 44(5): 744. CrossRef
Low- and high-dose radioiodine therapy for low-/intermediate-risk differentiated thyroid cancer: a preliminary clinical trial
Yuan Qu, Rui Huang, Lin Li
Annals of Nuclear Medicine.2017; 31(1): 71. CrossRef
ENDOCRINE TUMOURS: Imaging in the follow-up of differentiated thyroid cancer: current evidence and future perspectives for a risk-adapted approach
Livia Lamartina, Désirée Deandreis, Cosimo Durante, Sebastiano Filetti
European Journal of Endocrinology.2016; 175(5): R185. CrossRef
The risk of second primary malignancy is increased in differentiated thyroid cancer patients with a cumulative 131I dose over 37 GBq
Ah Reum Khang, Sun Wook Cho, Hoon Sung Choi, Hwa Young Ahn, Won Sang Yoo, Kyung Won Kim, Keon Wook Kang, Ka Hee Yi, Do Joon Park, Dong Soon Lee, June‐Key Chung, Bo Youn Cho, Young Joo Park
Clinical Endocrinology.2015; 83(1): 117. CrossRef
Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
Recent Changes in the Clinical Outcome of Papillary Thyroid Carcinoma With Cervical Lymph Node Metastasis
Min Ji Jeon, Won Gu Kim, Yun Mi Choi, Hyemi Kwon, Dong Eun Song, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Suck Joon Hong, Jung Hwan Baek, Jeong Hyun Lee, Jin-Sook Ryu, Tae Yong Kim, Young Kee Shong, Ki-Wook Chung, Won Bae Kim
The Journal of Clinical Endocrinology & Metabolism.2015; 100(9): 3470. CrossRef
Letter: Diagnostic Whole-Body Scan May Not Be Necessary for Intermediate-Risk Patients with Differentiated Thyroid Cancer after Low-Dose (30 mCi) Radioactive Iodide Ablation (Endocrinol Metab 2014;29:33-9, Eon Ju Jeon et al.)
Chan-Hee Jung
Endocrinology and Metabolism.2014; 29(2): 206. CrossRef

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