Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the general population and 40% to 70% of obese individuals. Adipose tissue plays a crucial role in its pathogenesis, as it produces and secretes pro- and anti-inflammatory cytokines called adipokines. Adiponectin and leptin have well-determined actions in terms of NAFLD pathophysiology. Adiponectin deficiency is associated with a pro-inflammatory condition, as it is observed in obesity and other metabolic disorders. On the other hand, increased leptin levels, above the normal levels, act as a pro-inflammatory stimulus. Regarding other adipokines (resistin, visfatin, chemerin, retinol-binding protein 4, irisin), data about their contribution to NAFLD pathogenesis and progression are inconclusive. In addition, pharmacological agents like thiazolidinediones (pioglitazone and rosiglitazone), that are used in the management of NAFLD exert favourable effects on adipokine levels, which in turn may contribute to the improvement of liver function. This review summarizes the current knowledge and developments in the association between adipokines and NAFLD and discusses possible therapeutic implications targeting the modulation of adipokine levels as a potential tool for the treatment of NAFLD.

Citations

Citations to this article as recorded by  

• Proanthocyanidins-Based Synbiotics as a Novel Strategy for Nonalcoholic Fatty Liver Disease (NAFLD) Risk Reduction
  Wasitha P. D. W. Thilakarathna, H. P. Vasantha Rupasinghe
  Molecules.2024; 29(3): 709.     CrossRef
• The role of novel adipokines and adipose-derived extracellular vesicles (ADEVs): Connections and interactions in liver diseases
  Lijun Xie, Huiying Wang, Jinying Hu, Zhuoying Liu, Fang Hu
  Biochemical Pharmacology.2024; 222: 116104.     CrossRef
• Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases
  Nikolaos Perakakis, Hani Harb, Benjamin G Hale, Zsuzsanna Varga, Charlotte Steenblock, Waldemar Kanczkowski, Vasileia Ismini Alexaki, Barbara Ludwig, Peter Mirtschink, Michele Solimena, Nicole Toepfner, Sebastian Zeissig, Manuel Gado, Irene Alma Abela, Fe
  The Lancet Diabetes & Endocrinology.2023; 11(9): 675.     CrossRef
• Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice
  Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh
  Hepatology.2023; 77(3): 888.     CrossRef
• Effect of Dietary Intervention, with or without Cointerventions, on Inflammatory Markers in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
  Renate L. Hall, Elena S. George, Audrey C. Tierney, Anjana J. Reddy
  Advances in Nutrition.2023; 14(3): 475.     CrossRef
• The Anti-Obesity and Anti-Steatotic Effects of Chrysin in a Rat Model of Obesity Mediated through Modulating the Hepatic AMPK/mTOR/lipogenesis Pathways
  Ghaleb Oriquat, Inas M. Masoud, Maher A. Kamel, Hebatallah Mohammed Aboudeya, Marwa B. Bakir, Sara A. Shaker
  Molecules.2023; 28(4): 1734.     CrossRef
• Association between caffeine intake and liver biomarkers in non-alcoholic fatty liver disease
  Kübra UÇAR, Evrim KAHRAMANOĞLU, Zeynep GÖKTAŞ
  Cukurova Medical Journal.2023; 48(1): 177.     CrossRef
• Changes in liver enzymes are associated with changes in insulin resistance, inflammatory biomarkers and leptin in prepubertal children with obesity
  Rosario Valle-Martos, Luis Jiménez-Reina, Ramón Cañete, Rosario Martos, Miguel Valle, María Dolores Cañete
  Italian Journal of Pediatrics.2023;[Epub]     CrossRef
• The key role of inflammation in the pathogenesis and management of obesity and CVD
  Chrysoula Boutari, Michael A. Hill, Claudio Procaccini, Giuseppe Matarese, Christos S. Mantzoros
  Metabolism.2023; 145: 155627.     CrossRef
• Obesity and diabetes
  Chrysoula Boutari, Antea DeMarsilis, Christos S. Mantzoros
  Diabetes Research and Clinical Practice.2023; 202: 110773.     CrossRef
• Identifying a distinct fibrosis subset of NAFLD via molecular profiling and the involvement of profibrotic macrophages
  Weiwei He, Yinxiang Huang, Xiulin Shi, Qingxuan Wang, Menghua Wu, Han Li, Qiuhong Liu, Xiaofang Zhang, Caoxin Huang, Xuejun Li
  Journal of Translational Medicine.2023;[Epub]     CrossRef
• The emerging significance of mitochondrial targeted strategies in NAFLD treatment
  Tao Zhang, Yingli Nie, Jiliang Wang
  Life Sciences.2023; 329: 121943.     CrossRef
• Association between leptin and NAFLD: a two-sample Mendelian randomization study
  Ziwei Guo, Hongbo Du, Yi Guo, Qian Jin, Ruijia Liu, Zhangjun Yun, Jiaxin Zhang, Xiaoke Li, Yong’an Ye
  European Journal of Medical Research.2023;[Epub]     CrossRef
• Liver fat as risk factor of hepatic and cardiometabolic diseases
  Münevver Demir, Stefan R. Bornstein, Christos S. Mantzoros, Nikolaos Perakakis
  Obesity Reviews.2023;[Epub]     CrossRef
• Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study
  Laura Valenzuela-Vallejo, Pavlina Chrysafi, Matina Kouvari, Valentina Guatibonza-Garcia, Sophia C. Mylonakis, Angeliki Katsarou, Ornella Verrastro, Georgios Markakis, Mohammed Eslam, Georgios Papatheodoridis, Geltrude Mingrone, Jacob George, Christos S. M
  Metabolism.2023; 148: 155694.     CrossRef
• Linalool attenuates lipid accumulation and oxidative stress in metabolic dysfunction-associated steatotic liver disease via Sirt1/Akt/PPRA-α/AMPK and Nrf-2/HO-1 signaling pathways
  P. Tamilmani, V. V. Sathibabu Uddandrao, P. Chandrasekaran, G. Saravanan, Parim Brahma Naidu, S. Sengottuvelu, S. Vadivukkarasi
  Clinics and Research in Hepatology and Gastroenterology.2023; 47(10): 102231.     CrossRef
• Uncovering the Cardiovascular Threat: A Comprehensive Examination of Liver Fibrosis and Subclinical Atherosclerosis in Non-alcoholic Fatty Liver Disease
  Niketa Sharma, Swarupa Chakole, Bhushan Wandile
  Cureus.2023;[Epub]     CrossRef
• Fetal programming by androgen excess impairs liver lipid content and PPARg expression in adult rats
  Aimé Florencia Silva, Giselle Adriana Abruzzese, María José Ferrer, María Florencia Heber, Silvana Rocío Ferreira, Gloria Edith Cerrone, Alicia Beatriz Motta
  Journal of Developmental Origins of Health and Disease.2022; 13(3): 300.     CrossRef
• Adipose tissue dysfunction and MAFLD in obesity on the scene of COVID-19
  Adryana Cordeiro, Amanda Ribamar, Andrea Ramalho
  Clinics and Research in Hepatology and Gastroenterology.2022; 46(3): 101807.     CrossRef
• Comparison of bioelectrical impedance analysis, mass index, and waist circumference in assessing risk for non-alcoholic steatohepatitis
  Katherine J.P. Schwenger, Alexander Kiu, Maryam AlAli, Amnah Alhanaee, Sandra E. Fischer, Johane P. Allard
  Nutrition.2022; 93: 111491.     CrossRef
• Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease
  Juan Moreno-Vedia, Josefa Girona, Daiana Ibarretxe, Lluís Masana, Ricardo Rodríguez-Calvo
  Biomedicines.2022; 10(1): 197.     CrossRef
• Predictive and Diagnostic Value of Serum Adipokines in Pregnant Women with Intrahepatic Cholestasis
  Nazan Yurtcu, Canan Soyer Caliskan, Huri Guvey, Samettin Celik, Safak Hatirnaz, Andrea Tinelli
  International Journal of Environmental Research and Public Health.2022; 19(4): 2254.     CrossRef
• Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows
  Susanne Häussler, Hassan Sadri, Morteza H. Ghaffari, Helga Sauerwein
  Journal of Dairy Science.2022; 105(4): 3648.     CrossRef
• Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
  Maria Martin-Grau, Vannina G Marrachelli, Daniel Monleon
  World Journal of Hepatology.2022; 14(2): 304.     CrossRef
• Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients – a Metabolic Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the Hepatokine/Adipokine Axis Breakdown
  Simona Alexandra Iacob, Diana Gabriela Iacob
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Protective Roles of Shilajit in Modulating Resistin, Adiponectin, and Cytokines in Rats with Non-alcoholic Fatty Liver Disease
  Baran Ghezelbash, Nader Shahrokhi, Mohammad Khaksari, Gholamreza Asadikaram, Maryam Shahrokhi, Sara Shirazpour
  Chinese Journal of Integrative Medicine.2022; 28(6): 531.     CrossRef
• The pathophysiological mechanism between hypopituitarism and nonalcoholic fatty liver disease
  Xinhe Zhang, Haoyu Tian, Yiling Li
  iLIVER.2022; 1(1): 65.     CrossRef
• Correlation of Adiponectin Gene Polymorphisms rs266729 and rs3774261 With Risk of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
  Yong-Tian Zheng, Tian-Mei Xiao, Chan-Xian Wu, Jin-Yan Cheng, Le-Yu Li
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches
  Mizael C. Araújo, Suzany H. S. Soczek, Jaqueline P. Pontes, Leonardo A. C. Marques, Gabriela S. Santos, Gisele Simão, Laryssa R. Bueno, Daniele Maria-Ferreira, Marcelo N. Muscará, Elizabeth S. Fernandes
  Cells.2022; 11(8): 1292.     CrossRef
• Skeletal muscle mass to visceral fat area ratio as a predictor of NAFLD in lean and overweight men and women with effect modification by sex
  Yoosun Cho, Yoosoo Chang, Seungho Ryu, Hyun‐Suk Jung, Chan‐won Kim, Hyungseok Oh, Mi Kyung Kim, Won Sohn, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne
  Hepatology Communications.2022; 6(9): 2238.     CrossRef
• The Perirenal Fat Thickness Was Associated with Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
  Yuxian Yang, Shuting Li, Yuechao Xu, Jing Ke, Dong Zhao
  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 1505.     CrossRef
• Non-alcoholic fatty liver disease development: A multifactorial pathogenic phenomena
  Aamir Bashir, Ajay Duseja, Arka De, Manu Mehta, Pramil Tiwari
  Liver Research.2022; 6(2): 72.     CrossRef
• Relationship between Liver Stiffness and Steatosis in Obesity Conditions: In Vivo and In Vitro Studies
  Francesca Baldini, Mohamad Khalil, Alice Bartolozzi, Massimo Vassalli, Agostino Di Ciaula, Piero Portincasa, Laura Vergani
  Biomolecules.2022; 12(5): 733.     CrossRef
• Nonalcoholic Steatohepatitis (NASH) and Atherosclerosis: Explaining Their Pathophysiology, Association and the Role of Incretin-Based Drugs
  Eleftheria Galatou, Elena Mourelatou, Sophia Hatziantoniou, Ioannis S. Vizirianakis
  Antioxidants.2022; 11(6): 1060.     CrossRef
• The epidemiology of non-alcoholic steatohepatitis (NASH) in the United States between 2010-2020: a population-based study
  Osama Hamid, Ahmed Eltelbany, Abdul Mohammed, Khaled Alsabbagh Alchirazi, Sushrut Trakroo, Imad Asaad
  Annals of Hepatology.2022; 27(5): 100727.     CrossRef
• Helicobacter Pylori-Induced Gastric Infections: From Pathogenesis to Novel Therapeutic Approaches Using Silver Nanoparticles
  Romelia Pop, Alexandru-Flaviu Tăbăran, Andrei Paul Ungur, Andrada Negoescu, Cornel Cătoi
  Pharmaceutics.2022; 14(7): 1463.     CrossRef
• Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs
  Natosha M. Mercado, Guanglin Zhang, Zhe Ying, Fernando Gómez-Pinilla
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2022; 1868(11): 166491.     CrossRef
• Detangling the interrelations between MAFLD, insulin resistance, and key hormones
  Shreya C. Pal, Mohammed Eslam, Nahum Mendez-Sanchez
  Hormones.2022; 21(4): 573.     CrossRef
• Historical Changes in Weight Classes and the Influence of NAFLD Prevalence: A Population Analysis of 34,486 Individuals
  Benjamin Kai Yi Nah, Cheng Han Ng, Kai En Chan, Caitlyn Tan, Manik Aggarwal, Rebecca Wenling Zeng, Jieling Xiao, Yip Han Chin, Eunice X. X. Tan, Yi Ping Ren, Douglas Chee, Jonathan Neo, Nicholas W. S. Chew, Michael Tseng, Mohammad Shadab Siddiqui, Arun J.
  International Journal of Environmental Research and Public Health.2022; 19(16): 9935.     CrossRef
• Adipokines in Non-Alcoholic Fatty Liver Disease: Are We on the Road toward New Biomarkers and Therapeutic Targets?
  Vera Francisco, Maria Jesus Sanz, José T. Real, Patrice Marques, Maurizio Capuozzo, Djedjiga Ait Eldjoudi, Oreste Gualillo
  Biology.2022; 11(8): 1237.     CrossRef
• Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis
  Juhyeong Hong, Yong‐Hee Kim
  Advanced Science.2022;[Epub]     CrossRef
• Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH
  Susanna C. Larsson, Karl Michaëlsson, Marina Mola-Caminal, Jonas Höijer, Christos S. Mantzoros
  Metabolism.2022; 137: 155329.     CrossRef
• Gender differences in the ideal cutoffs of visceral fat area for predicting MAFLD in China
  Pingping Yu, Huachao Yang, Xiaoya Qi, Ruixue Bai, Shouqin Zhang, Jianping Gong, Ying Mei, Peng Hu
  Lipids in Health and Disease.2022;[Epub]     CrossRef
• Apelin and chemerin receptors are G protein-coupled receptors involved in metabolic as well as reproductive functions: Potential therapeutic implications?
  Anthony Estienne, Alice Bongrani, Pascal Froment, Joëlle Dupont
  Current Opinion in Endocrine and Metabolic Research.2021; 16: 86.     CrossRef
• Metformin dose increase versus added linagliptin in non‐alcoholic fatty liver disease and type 2 diabetes: An analysis of the J‐LINK study
  Yasuji Komorizono, Kaori Hosoyamada, Naoko Imamura, Shoko Kajiya, Yasuhiro Hashiguchi, Norio Ueyama, Hirohiko Shinmaki, Nobuyuki Koriyama, Masako Tsukasa, Tetsuro Kamada
  Diabetes, Obesity and Metabolism.2021; 23(3): 832.     CrossRef
• Gender Differences in the Relationships among Metabolic Syndrome and Various Obesity-Related Indices with Nonalcoholic Fatty Liver Disease in a Taiwanese Population
  I-Ting Lin, Mei-Yueh Lee, Chih-Wen Wang, Da-Wei Wu, Szu-Chia Chen
  International Journal of Environmental Research and Public Health.2021; 18(3): 857.     CrossRef
• Leptin in Leanness and Obesity
  Nikolaos Perakakis, Olivia M. Farr, Christos S. Mantzoros
  Journal of the American College of Cardiology.2021; 77(6): 745.     CrossRef
• Severe insulin resistance syndromes
  Angeliki M. Angelidi, Andreas Filippaios, Christos S. Mantzoros
  Journal of Clinical Investigation.2021;[Epub]     CrossRef
• Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity
  Rosario Valle-Martos, Miguel Valle, Rosario Martos, Ramón Cañete, Luis Jiménez-Reina, María Dolores Cañete
  Frontiers in Pediatrics.2021;[Epub]     CrossRef
• From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)—New Terminology in Pediatric Patients as a Step in Good Scientific Direction?
  Marta Flisiak-Jackiewicz, Anna Bobrus-Chociej, Natalia Wasilewska, Dariusz Marek Lebensztejn
  Journal of Clinical Medicine.2021; 10(5): 924.     CrossRef
• Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives
  Christina-Maria Flessa, Ioannis Kyrou, Narjes Nasiri-Ansari, Gregory Kaltsas, Athanasios G. Papavassiliou, Eva Kassi, Harpal S. Randeva
  Current Obesity Reports.2021; 10(2): 134.     CrossRef
• Role of Insulin Resistance in MAFLD
  Yoshitaka Sakurai, Naoto Kubota, Toshimasa Yamauchi, Takashi Kadowaki
  International Journal of Molecular Sciences.2021; 22(8): 4156.     CrossRef
• Elafibranor and liraglutide improve differentially liver health and metabolism in a mouse model of non‐alcoholic steatohepatitis
  Nikolaos Perakakis, Konstantinos Stefanakis, Michael Feigh, Sanne S. Veidal, Christos S. Mantzoros
  Liver International.2021; 41(8): 1853.     CrossRef
• Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC
  Hyunmi Kim, Da Som Lee, Tae Hyeon An, Hyun-Ju Park, Won Kon Kim, Kwang-Hee Bae, Kyoung-Jin Oh
  International Journal of Molecular Sciences.2021; 22(9): 4495.     CrossRef
• Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors
  Oriol Juanola, Sebastián Martínez-López, Rubén Francés, Isabel Gómez-Hurtado
  International Journal of Environmental Research and Public Health.2021; 18(10): 5227.     CrossRef
• Serum Visfatin Levels in Nonalcoholic Fatty Liver Disease and Liver Fibrosis: Systematic Review and Meta-Analysis
  Abdulrahman Ismaiel, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Dan L. Dumitrascu
  Journal of Clinical Medicine.2021; 10(14): 3029.     CrossRef
• Possible Hepatoprotective Effect of Tocotrienol-Rich Fraction Vitamin E in Non-alcoholic Fatty Liver Disease in Obese Children and Adolescents
  Farah D.R. Al-Baiaty, Aziana Ismail, Zarina Abdul Latiff, Khairul Najmi Muhammad Nawawi, Raja Affendi Raja Ali, Norfilza Mohd Mokhtar
  Frontiers in Pediatrics.2021;[Epub]     CrossRef
• Adipokines in Insulin Resistance: Current Updates
  Utpal Jagdish Dongre
  Biosciences Biotechnology Research Asia.2021; 18(2): 357.     CrossRef
• Metabolic Effects of Gastrectomy and Duodenal Bypass in Early Gastric Cancer Patients with T2DM: A Prospective Single-Center Cohort Study
  Young Ki Lee, Eun Kyung Lee, You Jin Lee, Bang Wool Eom, Hong Man Yoon, Young-Il Kim, Soo Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Sun-Young Kong, Min Kyong Yoo, Yul Hwangbo, Young-Woo Kim, Il Ju Choi, Hak Jin Kim, Mi Hyang Kwak, Keun Won Ryu
  Journal of Clinical Medicine.2021; 10(17): 4008.     CrossRef
• Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial
  Fateme Kooshki, Fardin Moradi, Arash Karimi, Hamid Reza Niazkar, Manouchehr Khoshbaten, Vahid Maleki, Bahram Pourghassem Gargari
  European Journal of Gastroenterology & Hepatology.2021; 33(10): 1298.     CrossRef
• Specificities of lipotoxicity of free fatty acids and cytokine profile in patients with chronic diffuse liver diseases
  V. I. Didenko, I. A. Klenina, О. M. Tatarchuk, O. I. Hrabovska, O. P. Petishko
  Regulatory Mechanisms in Biosystems.2021; 13(1): 3.     CrossRef
• Markers of progression of liver fibrotic changes in patients with chronic toxic drug-induced hepatitis
  V.I. Didenko, O.M. Tatarchuk, O.P. Petishko, I.S. Konenko, S.L. Melanich
  GASTROENTEROLOGY.2021; 55(2): 91.     CrossRef
• Long-term abuse of a high-carbohydrate diet is as harmful as a high-fat diet for development and progression of liver injury in a mouse model of NAFLD/NASH
  Simona Pompili, Antonella Vetuschi, Eugenio Gaudio, Alessandra Tessitore, Roberta Capelli, Edoardo Alesse, Giovanni Latella, Roberta Sferra, Paolo Onori
  Nutrition.2020; 75-76: 110782.     CrossRef
• Targeted Analysis of Three Hormonal Systems Identifies Molecules Associated with the Presence and Severity of NAFLD
  Stergios A Polyzos, Nikolaos Perakakis, Chrysoula Boutari, Jannis Kountouras, Wael Ghaly, Athanasios D Anastasilakis, Asterios Karagiannis, Christos S Mantzoros
  The Journal of Clinical Endocrinology & Metabolism.2020; 105(3): e390.     CrossRef
• Inflammatory Mechanisms of HCC Development
  Maria Grazia Refolo, Caterina Messa, Vito Guerra, Brian Irving Carr, Rosalba D’Alessandro
  Cancers.2020; 12(3): 641.     CrossRef
• Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
  Robert F. Schwabe, Ira Tabas, Utpal B. Pajvani
  Gastroenterology.2020; 158(7): 1913.     CrossRef
• Visceral-to-Subcutaneous Abdominal Fat Ratio Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis
  Chan-Hee Jung, Eun-Jung Rhee, Hyemi Kwon, Yoosoo Chang, Seungho Ryu, Won-Young Lee
  Endocrinology and Metabolism.2020; 35(1): 165.     CrossRef
• Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8+ T-cells and galectin-3 in the liver
  Lisa Rein-Fischboeck, Elisabeth M. Haberl, Ganimete Bajraktari, Susanne Feder, Rebekka Pohl, Elke Eggenhofer, Christa Buechler
  Experimental and Molecular Pathology.2020; 113: 104363.     CrossRef
• Targeting of Secretory Proteins as a Therapeutic Strategy for Treatment of Nonalcoholic Steatohepatitis (NASH)
  Kyeongjin Kim, Kook Hwan Kim
  International Journal of Molecular Sciences.2020; 21(7): 2296.     CrossRef
• Non-Alcoholic Fatty Liver Disease Treatment in Patients with Type 2 Diabetes Mellitus; New Kids on the Block
  Vasilios G. Athyros, Stergios A. Polyzos, Jiannis Kountouras, Niki Katsiki, Panagiotis Anagnostis, Michael Doumas, Christos S. Mantzoros
  Current Vascular Pharmacology.2020; 18(2): 172.     CrossRef
• High body mass index hinders fibrosis improvement in patients receiving long‐term tenofovir therapy in hepatitis B virus‐related cirrhosis
  Young Eun Chon, Kyu Sik Jung, Yeonjung Ha, Mi Na Kim, Joo Ho Lee, Seong Gyu Hwang, Sang Hoon Ahn, Do Young Kim, Kwang‐Hyub Han, Jun Yong Park
  Journal of Viral Hepatitis.2020; 27(11): 1119.     CrossRef
• The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease
  Nikolaos Perakakis, Konstantinos Stefanakis, Christos S. Mantzoros
  Metabolism.2020; 111: 154320.     CrossRef
• The Selective Peroxisome Proliferator‐Activated Receptor Gamma Modulator CHS‐131 Improves Liver Histopathology and Metabolism in a Mouse Model of Obesity and Nonalcoholic Steatohepatitis
  Nikolaos Perakakis, Aditya Joshi, Natia Peradze, Konstantinos Stefanakis, Georgia Li, Michael Feigh, Sanne Skovgard Veidal, Glenn Rosen, Michael Fleming, Christos S. Mantzoros
  Hepatology Communications.2020; 4(9): 1302.     CrossRef
• Osteocalcin and osteoprotegerin levels and their relationship with adipokines and proinflammatory cytokines in children with nonalcoholic fatty liver disease
  Doaa El Amrousy, Dalia El-Afify
  Cytokine.2020; 135: 155215.     CrossRef
• The effect of saffron supplementation on some inflammatory and oxidative markers, leptin, adiponectin, and body composition in patients with nonalcoholic fatty liver disease: A double‐blind randomized clinical trial
  Farnaz Kavianipour, Naheed Aryaeian, Marjan Mokhtare, Reyhanesadat Mirnasrollahiparsa, Leila Jannani, Shahram Agah, Sodabeh Fallah, Nariman Moradi
  Phytotherapy Research.2020; 34(12): 3367.     CrossRef
• Hepatic Lipidomics and Molecular Imaging in a Murine Non-Alcoholic Fatty Liver Disease Model: Insights into Molecular Mechanisms
  Ricardo Rodríguez-Calvo, Sara Samino, Josefa Girona, Neus Martínez-Micaelo, Pere Ràfols, María García-Altares, Sandra Guaita-Esteruelas, Alexandra Junza, Mercedes Heras, Oscar Yanes, Xavier Correig, Lluis Masana
  Biomolecules.2020; 10(9): 1275.     CrossRef
• The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling
  Samukelisiwe C. Shabalala, Phiwayinkosi V. Dludla, Lawrence Mabasa, Abidemi P. Kappo, Albertus K. Basson, Carmen Pheiffer, Rabia Johnson
  Biomedicine & Pharmacotherapy.2020; 131: 110785.     CrossRef
• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
  Na Xie, Lu Zhang, Wei Gao, Canhua Huang, Peter Ernst Huber, Xiaobo Zhou, Changlong Li, Guobo Shen, Bingwen Zou
  Signal Transduction and Targeted Therapy.2020;[Epub]     CrossRef
• Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects
  Gayane Sargis Vardanyan, Hasmik Samvel Harutyunyan, Michail Iosif Aghajanov, Ruben Sargis Vardanyan
  Future Medicinal Chemistry.2020; 12(20): 1865.     CrossRef
• Unraveling the Role of Leptin in Liver Function and Its Relationship with Liver Diseases
  Maite Martínez-Uña, Yaiza López-Mancheño, Carlos Diéguez, Manuel A. Fernández-Rojo, Marta G. Novelle
  International Journal of Molecular Sciences.2020; 21(24): 9368.     CrossRef
• Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression
  Ming-Ling Chang, Zinger Yang, Sien-Sing Yang
  International Journal of Molecular Sciences.2020; 21(21): 8308.     CrossRef
• CHANGES IN CARBOHYDRATE METABOLISM AND ADIPOCYTOKINES UNDER THE INFLUENCE OF TREATMENT OF PATIENTS WITH ALCOHOLIC CIRRHOSIS OF THE LIVER IN COMBINATION WITH OBESITY USING ADAMETHIONINUM AND ARGININE GLUTAMATE
  N. R. Matkovska
  Medical and Clinical Chemistry.2020; (3): 17.     CrossRef
• Effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Ex quo et quo vadimus?
  Niki Katsiki, Nikolaos Perakakis, Christos Mantzoros
  Metabolism.2019; 98: iii.     CrossRef
• Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children
  Gulsah Kaya Aksoy, Reha Artan, Cihat Aksoy, Sebahat Özdem, Atike Atalay, Aygen Yılmaz
  Pediatric Gastroenterology, Hepatology & Nutrition.2019; 22(5): 470.     CrossRef
• Determinants of ectopic liver fat in metabolic disease
  Anja Bosy-Westphal, Wiebke Braun, Viktoria Albrecht, Manfred J. Müller
  European Journal of Clinical Nutrition.2019; 73(2): 209.     CrossRef
• Involvement of the hepatic branch of the vagus nerve in the regulation of plasma adipokine levels in rats fed a high-fructose diet
  Naoto Hashimoto, Manabu Wakagi, Katsunari Ippoushi, Yuko Takano-Ishikawa
  The Journal of Nutritional Biochemistry.2019; 71: 90.     CrossRef
• Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease
  Ines C.M. Simoes, Justyna Janikiewicz, Judith Bauer, Agnieszka Karkucinska-Wieckowska, Piotr Kalinowski, Agnieszka Dobrzyń, Andrzej Wolski, Maciej Pronicki, Krzysztof Zieniewicz, Paweł Dobrzyń, Marcin Krawczyk, Hans Zischka, Mariusz R. Wieckowski, Yaiza P
  Nutrients.2019; 11(12): 2871.     CrossRef
• Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood
  Susann Weihrauch-Blüher, Peter Schwarz, Jan-Henning Klusmann
  Metabolism.2019; 92: 147.     CrossRef
• Effects of moderate-intensity continuous training and high-intensity interval training on serum levels of Resistin, Chemerin and liver enzymes in Streptozotocin-Nicotinamide induced Type-2 diabetic rats
  Parastesh Mohammad, Khosravi Zadeh Esfandiar, Saremi Abbas, Rekabtalae Ahoora
  Journal of Diabetes & Metabolic Disorders.2019; 18(2): 379.     CrossRef
• Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics
  Stergios A. Polyzos, Jannis Kountouras, Christos S. Mantzoros
  Metabolism.2019; 92: 82.     CrossRef
• The Latest Insights into Adipokines in Diabetes
  Won Kon Kim, Kwang-Hee Bae, Sang Chul Lee, Kyoung-Jin Oh
  Journal of Clinical Medicine.2019; 8(11): 1874.     CrossRef
• Postprandial leptin and adiponectin in response to sugar and fat in obese and normal weight individuals
  M. A. Larsen, V. T. Isaksen, E. J. Paulssen, R. Goll, J. R. Florholmen
  Endocrine.2019; 66(3): 517.     CrossRef
• First demonstration of protective effects of purified mushroom polysaccharide-peptides against fatty liver injury and the mechanisms involved
  Shuang Zhao, Shuman Zhang, Weiwei Zhang, Yi Gao, Chengbo Rong, Hexiang Wang, Yu Liu, Jack Ho Wong, Tzibun Ng
  Scientific Reports.2019;[Epub]     CrossRef
• Applying Non-Invasive Fibrosis Measurements in NAFLD/NASH: Progress to Date
  Somaya Albhaisi, Arun J. Sanyal
  Pharmaceutical Medicine.2019; 33(6): 451.     CrossRef
• Adiponectin rs2241766 and rs266729 gene polymorphisms in non-alcoholic fatty liver disease
  Aida A. Mahmoud, Hoda M. Moghazy, Laila M. Yousef, Asmaa N. Mohammad
  Gene Reports.2019; 15: 100381.     CrossRef
• Non-invasive diagnosis of non-alcoholic steatohepatitis and fibrosis with the use of omics and supervised learning: A proof of concept study
  Nikolaos Perakakis, Stergios A. Polyzos, Alireza Yazdani, Aleix Sala-Vila, Jannis Kountouras, Athanasios D. Anastasilakis, Christos S. Mantzoros
  Metabolism.2019; 101: 154005.     CrossRef
• Association between Helicobacter pylori infection and nonalcoholic fatty liver
  Rongqiang Liu, Qiuli Liu, Ying He, Wenqing Shi, Qianhui Xu, Qing Yuan, Qi Lin, Biao Li, Lei Ye, Youlan Min, Peiwen Zhu, Yi Shao
  Medicine.2019; 98(44): e17781.     CrossRef
• CHANGES IN CARBOHYDRATE METABOLISM IN PATIENTS WITH ALCOHOLIC CIRRHOSIS OF THE LIVER ASSOCIATED WITH NON-ALCOHOLIC FATTY LIVER DISEASE DEPENDING ON THE STAGE OF DECOMPENSATION
  Nataliia Matkovska, Nataliia Virstiuk, Uliana Balan
  International Academy Journal Web of Scholar.2019; (6(36)): 17.     CrossRef
• Non-alcoholic fatty liver disease and colorectal cancer: A marker of risk or common causation?
  Niki Katsiki, Dimitri P. Mikhailidis, Christos Mantzoros
  Metabolism.2018; 87: A10.     CrossRef
• Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions
  Chenggui Miao, Zhongwen Xie, Jun Chang
  Biochemical Genetics.2018; 56(5): 423.     CrossRef
• Alpha-syntrophin dependent expression of tubulin alpha 8 protein in hepatocytes
  Lisa Rein-Fischboeck, Ganimete Bajraktari, Rebekka Pohl, Susanne Feder, Kristina Eisinger, Wolfgang Mages, Elisabeth M. Haberl, Christa Buechler
  Journal of Physiology and Biochemistry.2018; 74(4): 511.     CrossRef
• Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
  Kook Hwan Kim, Myung-Shik Lee
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Helicobacter pyloriand extragastric diseases: A review
  Antonietta Gerarda Gravina, Rocco Maurizio Zagari, Cristiana De Musis, Lorenzo Romano, Carmelina Loguercio, Marco Romano
  World Journal of Gastroenterology.2018; 24(29): 3204.     CrossRef
• Thiazolidinedione induces a therapeutic effect on hepatosteatosis by regulating stearoyl‑CoA desaturase‑1, lipase activity, leptin and resistin
  Hessah Al‑Muzafar, Kamal Amin
  Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
• Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice
  Xin Li, Li Jiang, Miao Yang, Yu‑Wen Wu, Jia‑Zhong Sun
  Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
• Analysis of non‑alcoholic fatty liver disease microRNA expression spectra in rat liver tissues
  Jiao Nie, Chang‑Ping Li, Jue‑Hong Li, Xia Chen, Xiaoling Zhong
  Molecular Medicine Reports.2018;[Epub]     CrossRef

Citations

Citations to this article as recorded by  

• Insulin resistance, leptin and adiponectin in lean and hypothyroid children and adolescents with obesity
  Doaa El Amrousy, Dalia El-Afify, Shaimaa Salah
  BMC Pediatrics.2022;[Epub]     CrossRef
• Mediators of energy homeostasis in hyperthyroidism
  Avinash Patil, Suresh Vaikkakara, Mani Deepthi Dasari, Sandeep Ganta, Alok Sachan, Kiranmayi S. Vinapamula
  Archives of Endocrinology and Metabolism.2022;[Epub]     CrossRef
• STUDY OF GHRELIN LEVELS IN HYPOTHYROID PATIENTS BEFORE AND AFTER TREATMENT
  Peeyush Yadav, G. G. Kaushik
  INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 52.     CrossRef
• Acylated Ghrelin Attenuates l-Thyroxin–induced Cardiac Damage in Rats by Antioxidant and Anti-inflammatory Effects and Downregulating Components of the Cardiac Renin–angiotensin System
  Rehab Badi
  Journal of Cardiovascular Pharmacology.2021; 78(3): 422.     CrossRef
• Experimental hypothyroidism in adult male rats: the effects of Artemisia dracunculus aqueous extract on serum thyroid hormones, lipid profile, leptin, adiponectin, and antioxidant factors
  Mohammad Mohsen Mohammadi, Mahdi Saeb, Saeed Nazifi
  Comparative Clinical Pathology.2020; 29(2): 485.     CrossRef
• Leptin, neuropeptide Y (NPY), melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: relation with melatonin and the pineal gland
  Abdulkerim Kasım Baltaci, Rasim Mogulkoc
  Hormone Molecular Biology and Clinical Investigation.2018;[Epub]     CrossRef
• Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc
  Abdulkerim Kasım Baltaci, Rasim Mogulkoc
  Biochemical Genetics.2017; 55(3): 223.     CrossRef
• Thyroid Hormone Regulation and Insulin Resistance: Insights From Animals Naturally Adapted to Fasting
  Bridget Martinez, Rudy M. Ortiz
  Physiology.2017; 32(2): 141.     CrossRef
• Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis
  Antonietta Messina, Carolina De Fusco, Vincenzo Monda, Maria Esposito, Fiorenzo Moscatelli, Anna Valenzano, Marco Carotenuto, Emanuela Viggiano, Sergio Chieffi, Vincenzo De Luca, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina
  Frontiers in Neural Circuits.2016;[Epub]     CrossRef
• Serum Concentrations of Ghrelin and Leptin according to Thyroid Hormone Condition, and Their Correlations with Insulin Resistance (Endocrinol Metab2015;30:318-25, Kyu-Jin Kim et al.)
  Jin Hwa Kim
  Endocrinology and Metabolism.2015; 30(4): 631.     CrossRef
• Serum Concentrations of Ghrelin and Leptin according to Thyroid Hormone Condition, and Their Correlations with Insulin Resistance (Endocrinol Metab2015;30:318-25, Kyu-Jin Kim et al.)
  Chan-Hee Jung
  Endocrinology and Metabolism.2015; 30(4): 633.     CrossRef

To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by the central nervous system. In particular, a comprehension of the fine cellular interplay and intracellular mechanisms that enable appropriate hypothalamic and consequent endocrine and behavioral responses to both circulating hormonal and nutrient signals remains elusive. Recent data, including those from our laboratories, raised the notion that reactive oxygen species (ROS) generation is not merely a by-product of substrate oxidation, but it plays a crucial role in modulating cellular responses involved in the regulation of energy metabolism. These review summarizes the published recent data on the effect of ROS levels in the regulation of neuronal function, including that of hypothalamic melanocortin neurons, pro-opiomelanocortin and neuropeptide Y-/agouti related peptide-neurons, in the modulation of food intake.

Citations

Citations to this article as recorded by  

• Regulation of hypothalamic reactive oxygen species and feeding behavior by phosphorylation of the beta 2 thyroid hormone receptor isoform
  Svetlana Minakhina, Sun Young Kim, Fredric E. Wondisford
  Scientific Reports.2024;[Epub]     CrossRef
• Overexpression of PpmTERF18 enhances the antioxidant capacity of peach fruit to alleviate oxidative damage
  Xiaoshan Guo, Guangqin Jing, Shuhua Zhu, Jianrong Feng, Dandan Huang
  Scientia Horticulturae.2023; 318: 112123.     CrossRef
• Insights into the promising prospect of pharmacological approaches targeting mitochondrial dysfunction in major human diseases: At a glance
  Md.Mominur Rahman, Md.Taslim Sarker, Sabbir Ahmed, Md.Nur Uddin, Md.Shariful Islam, Md.Rezaul Islam, Shanto Das, Nobendu Mukherjee, Hassan A. Hemeg, Abdur Rauf, Bimal Kumar Ghimire, Muthu Thiruvengadam
  Process Biochemistry.2023; 132: 41.     CrossRef
• Structure-based analysis and rational design of human peroxiredoxin-1's C-terminus-derived peptides to target sulfiredoxin-1 in pancreatic cancer
  Xiaoqiong Wu, Rongyuan Qiu, Wei Yi, Juan Chen, Zhou Zhang, Ji Zhang, Zhiyuan Zhu
  Biophysical Chemistry.2022; 288: 106857.     CrossRef
• Drp1 is required for AgRP neuronal activity and feeding
  Sungho Jin, Nal Ae Yoon, Zhong-Wu Liu, Jae Eun Song, Tamas L Horvath, Jung Dae Kim, Sabrina Diano
  eLife.2021;[Epub]     CrossRef
• Mechanism of deoxynivalenol mediated gastrointestinal toxicity: Insights from mitochondrial dysfunction
  Shuai Wang, Kuntan Wu, Dongfang Xue, Cong Zhang, Shahid Ali Rajput, Desheng Qi
  Food and Chemical Toxicology.2021; 153: 112214.     CrossRef
• Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects
  Marc Fransen, Celien Lismont
  Antioxidants & Redox Signaling.2019; 30(1): 95.     CrossRef
• The melanocortin pathway and control of appetite-progress and therapeutic implications
  Giulia Baldini, Kevin D Phelan
  Journal of Endocrinology.2019; 241(1): R1.     CrossRef
• Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration
  Mengshi Zhang, Youwei Chen, Hanqian Xu, Li Yang, Feng Yuan, Lei Li, Ying Xu, Ying Chen, Chao Zhang, Gufa Lin
  Developmental Cell.2018; 46(4): 397.     CrossRef
• Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease
  Juan Cunarro, Sabela Casado, Javier Lugilde, Sulay Tovar
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Role of oxidative stress and antioxidants in daily nutrition and human health
  Geir Bjørklund, Salvatore Chirumbolo
  Nutrition.2017; 33: 311.     CrossRef
• DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons
  Anna Santoro, Michela Campolo, Chen Liu, Hiromi Sesaki, Rosaria Meli, Zhong-Wu Liu, Jung Dae Kim, Sabrina Diano
  Cell Metabolism.2017; 25(3): 647.     CrossRef
• Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats
  Virginia Mela, Oskarina Hernandez, Caroline Hunsche, Francisca Diaz, Julie A. Chowen, Mónica De la Fuente
  Molecular and Cellular Endocrinology.2017; 454: 125.     CrossRef
• Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells
  Hye-Jin Jung, Seung-Soon Im, Dae-Kyu Song, Jae-Hoon Bae
  BMB Reports.2017; 50(6): 323.     CrossRef
• Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction
  Ailan Chen, Wanglin Li, Xinyu Chen, Yuechun Shen, Wenjun Dai, Qi Dong, Xinchun Li, Caiwen Ou, Minsheng Chen
  BMC Cardiovascular Disorders.2016;[Epub]     CrossRef
• Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
  Seung-Jae Kim, Ji-Young Cha, Hye Suk Kang, Jae-Ho Lee, Ji Yoon Lee, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im
  BMB Reports.2016; 49(5): 276.     CrossRef
• The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development
  Murli Mishra, Hong Jiang, Lisha Wu, Hedy A. Chawsheen, Qiou Wei
  Cancer Letters.2015; 366(2): 150.     CrossRef
• Effects of methanolic extracts of edible plants on RAGE in high-glucose-induced human endothelial cells
  Mizue Okada, Yoshinori Okada
  Bio-Medical Materials and Engineering.2015; 25(3): 257.     CrossRef
• Reactive oxygen species are physiological mediators of the noradrenergic signaling pathway in the mouse supraoptic nucleus
  Ronald St-Louis, Caroline Parmentier, Valérie Grange-Messent, Sakina Mhaouty-Kodja, Hélène Hardin-Pouzet
  Free Radical Biology and Medicine.2014; 71: 231.     CrossRef
• Reactive oxygen species play a role in muscle wasting during thyrotoxicosis
  Sara Santos Bernardes, Flávia Alessandra Guarnier, Poliana Camila Marinello, André Armani, Andréa Name Colado Simão, Rubens Cecchini, Alessandra Lourenço Cecchini
  Cell and Tissue Research.2014; 357(3): 803.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef

Citations

Citations to this article as recorded by  

• Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans
  Laetitia Chauve, Francesca Hodge, Sharlene Murdoch, Fatemeh Masoudzadeh, Harry-Jack Mann, Andrea F. Lopez-Clavijo, Hanneke Okkenhaug, Greg West, Bebiana C. Sousa, Anne Segonds-Pichon, Cheryl Li, Steven W. Wingett, Hermine Kienberger, Karin Kleigrewe, Mari
  PLOS Biology.2021; 19(11): e3001431.     CrossRef

Citations

Citations to this article as recorded by  

• Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats
  Sevag Hamamah, Andras Hajnal, Mihai Covasa
  International Journal of Molecular Sciences.2023; 24(11): 9773.     CrossRef
• Improvement of Leptin Resistance
  Yong Woon Kim
  Yeungnam University Journal of Medicine.2013; 30(1): 4.     CrossRef
• The Effect of Food Restriction on Appetite Regulating Hormones and Adiponectin Activity
  Ki Hoon Kim, Hyun Kook Kim
  Korean Journal of Nutrition.2012; 45(1): 5.     CrossRef
• The Effect of Leptin Level Fluctuations by a Repeated Fasting/Refeeding on the Leptin Sensitivity in OLETF Rats
  Min Seon Kim
  Journal of Korean Endocrine Society.2008; 23(5): 298.     CrossRef

Citations

Citations to this article as recorded by  

• Naloxone Increases the Anorexic Effect of Melanocortin II
  Seungjoon Park
  Journal of Korean Endocrine Society.2008; 23(1): 15.     CrossRef

Citations

Citations to this article as recorded by  

• Effect of Fenofibrate and Exercise on Metabolic Syndrome and Hepatic Steatosis
  Bong Soo Cha, Jae Hyuk Lee
  Journal of Korean Endocrine Society.2007; 22(3): 188.     CrossRef

Citations

Citations to this article as recorded by  

• Relationships among Serum Adiponectin, Leptin and Vitamin D Concentrations and the Metabolic Syndrome in Farmers
  Seo-Eun Yeon, Hee-Ryoung Son, Jung-Sook Choi, Eun-Kyung Kim
  Korean Journal of Community Nutrition.2014; 19(1): 12.     CrossRef
• The Effect of Visceral Fat Area and Adipocytokines on Acute Myocardial Infarction: A Case-Control Study in Adult Korean Population
  Kang-Kon Lee, Young-Sung Suh, Keun-Sang Yum
  The Korean Journal of Obesity.2012; 21(1): 57.     CrossRef