Endocrinology and Metabolism

Original Articles

Clinical Study
Iodine Status in Filipino Women of Childbearing Age: Michael E. Serafico, Joselita Rosario C. Ulanday, Marites V. Alibayan, Glen Melvin P. Gironella, Leah A. Perlas; Endocrinol Metab. 2018;33(3):372-379. Published online September 18, 2018; DOI: https://doi.org/10.3803/EnM.2018.33.3.372

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Background

Iodine deficiency (ID) has become a concern not only among pregnant women, but in women of childbearing age as well. In fact, a recent report suggested that women with moderate to severe ID may experience a significantly longer time to conceive. This study aimed to investigate iodine status in Filipino women of childbearing age.

Methods

The iodine status of 6,194 Filipino women aged 15 to 45 years old was assessed through urinary iodine analysis. A casual spot urine sample was collected from women in households participating in the eighth National Nutrition Survey conducted by the Food and Nutrition Research Institute. The sample was analyzed using ammonium persulfate digestion followed by the Sandell-Kolthoff colorimetric reaction. A median urinary iodine concentration (UIC) of less than 100 µg/L was used to define ID.

Results

The median UIC was 123 µg/L, indicative of adequate iodine nutrition; however, 21.5% of participants had a UIC below 50 µg/L. The median UIC of women who lived in urban areas (142 µg/L), belonged to the middle to richest class (>124 µg/L), had reached a college education (136 µg/L), and used iodized salt (15 ppm and above; 148 to 179 µg/L) reflected adequate iodine nutrition. ID was found to have been eliminated in the regions of Central Luzon, Eastern Visayas, Calabarzon, Mimaropa, and the National Capital, while mild ID was identified in Western Visayas, Southern and Western Mindanao, and in the Autonomous Region in Muslim Mindanao.

Conclusion

Pockets of ID among women of childbearing age exist in the Philippines. Proper information through education and the use of adequately iodized salt are key measures for improving the iodine status of the studied population.

Citations

Citations to this article as recorded by

Adequate iodine nutrition and higher salt intake in Chinese adults aged 18–59 years recommended by international organizations
Diqun Chen, Ying Ye, Ying Lan, Meng He, Jiani Wu, Lijin Wang, Zhihui Chen
Scientific Reports.2024;[Epub] CrossRef
Burden and trends of iodine deficiency in Asia from 1990 to 2019
R. Wei, Z. Wang, X. Zhang, X. Wang, Y. Xu, Q. Li
Public Health.2023; 222: 75. CrossRef
The Iodine Status and Prevalence of Thyroid Disorders Among Women of Childbearing Age in China: National Cross-sectional Study
Yongze Li, Zhongyan Shan, Weiping Teng
Endocrine Practice.2021; 27(10): 1028. CrossRef
Female Fertility and the Nutritional Approach: The Most Essential Aspects
Kinga Skoracka, Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
Advances in Nutrition.2021; 12(6): 2372. CrossRef
Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population
Songlin Yu, Danchen Wang, Xinqi Cheng, Qiong Zhang, Mingxue Wang, Haipeng Guo, Benzhang Yu, Xiuming Zhang, Liangyu Xia, Dandan Sun, Qian Cheng, Pengchang Li, Yicong Yin, Chaochao Ma, Li'an Hou, Yutong Zou, Honglei Li, Dandan Li, Ling Qiu, Kiyoshi Ichihara
Clinica Chimica Acta.2020; 502: 34. CrossRef
Response: Iodine Status in Filipino Women of Childbearing Age (Endocrinol Metab 2018;33:372-9, Michael E. Serafico et al.)
Michael E. Serafico
Endocrinology and Metabolism.2018; 33(4): 495. CrossRef
Letter: Iodine Status in Filipino Women of Childbearing Age (Endocrinol Metab 2018;33:372-9, Michael E. Serafico et al.)
Zheng Feei Ma
Endocrinology and Metabolism.2018; 33(4): 493. CrossRef

Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population: Marc Gregory Yu, Jonathan Rivera, Cecilia Jimeno; Endocrinol Metab. 2017;32(2):288-295. Published online June 23, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.2.288

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60 Download
14 Web of Science
10 Crossref

Abstract PDF PubReader

Background

No previous studies have been published on poorly differentiated thyroid carcinoma (PDTC) in Southeast Asia.

Methods

We included all adult PDTC patients diagnosed using the Turin criteria at the Philippine General Hospital from 2006 to 2015. The data collected included demographics, clinical presentation, histopathology, treatment, and outcomes. Tests of association were employed to compare these data with foreign studies on PDTC, as well as with local studies on well differentiated thyroid carcinoma (WDTC) and anaplastic thyroid carcinoma (ATC).

Results

Eighteen PDTC cases were identified. The median age was 62 years old, with the majority being females. All patients had goiter on presentation, and most were stage IV at the time of diagnosis. In terms of PDTC subtype, insular and trabecular patterns were equally common. Extrathyroidal extension was documented in eight patients, while five patients each had nodal and distant metastasis. All but one patient underwent surgery; however, less than half received adjuvant radioiodine therapy. The 5-year survival rate was 83%. Three patients (16.7%) died at a median of 12 months after diagnosis. Nine (50%) are still alive with persistent and/or recurrent disease at a median of 39 months after diagnosis.

Conclusion

The behavior of PDTC in this Southeast Asian population was found to be similar to patterns observed in other regions, and exhibited intermediate features between WDTC and ATC. Appropriate surgery provided excellent 5-year survival rates, but the role of adjuvant therapy remains unclear. Larger studies are needed to identify prognostic factors in this population.

Citations

Citations to this article as recorded by

Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact
Andrés Coca-Pelaz, Juan P. Rodrigo, Abbas Agaimy, Michelle D. Williams, Nabil F. Saba, Sandra Nuyts, Gregory W. Randolph, Fernando López, Vincent Vander Poorten, Luiz P. Kowalski, Francisco J. Civantos, Mark E. Zafereo, Antti A. Mäkitie, Oded Cohen, Iain
Virchows Archiv.2024;[Epub] CrossRef
Management of Poorly Differentiated Thyroid Cancer and Differentiated High-Grade Thyroid Carcinoma
Iram S. Alam, Kepal N. Patel
Surgical Clinics of North America.2024;[Epub] CrossRef
I-131 Avid Tumor Thrombus in a Case of Poorly Differentiated Thyroid Cancer
Sana Munir Gill, Aamna Hassan, Humayun Bashir, Waqas Shafiq
Molecular Imaging and Radionuclide Therapy.2023; 32(2): 178. CrossRef
Prognostic Impact of Focal Poorly Differentiated Areas in Follicular Differentiated Thyroid Cancer: Is It a Distinct Entity from Poorly Differentiated Thyroid Cancer?
Ramakanth Bhargav Panchangam, Pradeep Puthenveetil, Sabaretnam Mayilvaganan
Indian Journal of Surgical Oncology.2022; 13(1): 157. CrossRef
Newly proposed survival staging system for poorly differentiated thyroid cancer: a SEER-based study
W. Sun, Z. Wang, J. Xiang, Y. Qin, F. Zhang, H. Zhang
Journal of Endocrinological Investigation.2022; 46(5): 947. CrossRef
Clinicopathological Characteristics and Prognosis of Poorly Differentiated Thyroid Carcinoma Diagnosed According to the Turin Criteria
Jiapeng Huang, Wei Sun, Qingfu Zhang, Zhihong Wang, Wenwu Dong, Dalin Zhang, Chengzhou Lv, Liang Shao, Ping Zhang, Hao Zhang
Endocrine Practice.2021; 27(5): 401. CrossRef
Osteopontin Expression in Thyroid Cancer: Deciphering EMT-Related Molecular Mechanisms
Bruna Prunes Pena Baroni Viana, Amanda Vitória Pampolha Gomes, Etel Rodrigues Pereira Gimba, Luciana Bueno Ferreira
Biomedicines.2021; 9(10): 1372. CrossRef
Poorly differentiated thyroid carcinoma (PDTC) characteristics and the efficacy of radioactive iodine (RAI) therapy as an adjuvant treatment in a tertiary cancer care center
Shivakumar Thiagarajan, Aamir Yousuf, Ratan Shetty, Harsh Dhar, Yash Mathur, Deepa Nair, Sandeep Basu, Asawari Patil, Shubadha Kane, Sarbani Ghosh-Laskar, Devendra Chaukar
European Archives of Oto-Rhino-Laryngology.2020; 277(6): 1807. CrossRef
Major vessel invasion by thyroid cancer: a comprehensive review
Michael S. Xu, Jennifer Li, Sam M. Wiseman
Expert Review of Anticancer Therapy.2019; 19(2): 191. CrossRef
Poorly differentiated thyroid carcinoma and poorly differentiated area in differentiated thyroid carcinoma: is there any difference?
Raouef Ahmed Bichoo, Anjali Mishra, Niraj Kumari, Narendra Krishnani, Gyan Chand, Gaurav Agarwal, Amit Agarwal, Saroj Kanta Mishra
Langenbeck's Archives of Surgery.2019; 404(1): 45. CrossRef

Thyroid
Anaplastic Thyroid Cancer: Experience of the Philippine General Hospital: Tom Edward Lo, Cecilia Alegado Jimeno, Elizabeth Paz-Pacheco; Endocrinol Metab. 2015;30(2):195-200. Published online June 30, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.2.195

3,464 View
42 Download
4 Web of Science
4 Crossref

Abstract PDF PubReader

Background

Anaplastic thyroid cancer (ATC) is a rare type of thyroid malignancy and one of the most aggressive solid tumors, responsible for between 14% and 50% of the total annual mortality associated with thyroid cancer.

Methods

A retrospective study was made of all ATC cases diagnosed by biopsy in the Philippine General Hospital between 2008 and 2013.

Results

A total of 15 patients were identified, with a median age at diagnosis of 63 years. All tumors were at least 6 cm in size upon diagnosis. All patients had a previous history of thyroid pathology, presenting with an average duration of 11 years. Eleven patients presented with cervical lymphadenopathies, whereas seven exhibited signs of distant metastases, for which the lungs appeared to be the most common site. More than 70% of the patients presented with a rapidly growing neck mass, leading to airway obstruction. Only three patients were treated using curative surgery; the majority received palliative and supportive forms of treatment. In addition, only three patients were offered radiotherapy. Chemotherapy was not offered to any patient. Only two patients were confirmed to still be alive during the study period. The median survival time for the other patients was 3 months; in the majority of cases the patient died within the first year following diagnosis.

Conclusion

Our experience with ATC demonstrated concordance with other institutions with respect to current clinical profile, presentation, and prognosis. An absence of distant metastases and lymph node involvement was associated with improved survival outcomes, whereas age at diagnosis and tumor size did not affect survival. Curative surgery offers the most effective means of prolonging survival. Radiotherapy and chemotherapy in combination with surgery represents a promising treatment strategy.

Citations

Citations to this article as recorded by

Prior Thyroid and Nonthyroid Cancer History Do Not Significantly Alter Overall Survival in Patients Diagnosed with Anaplastic Thyroid Cancer
Yu Han Chen, Maria Cabanillas, Jared Sperling, Li Xu, Maitrayee Goswami, Anastasios Maniakas, Michelle D. Williams, Stephen Y. Lai, Naifa Busaidy, Ramona Dadu, Mark E. Zafereo, Jennifer Rui Wang
Thyroid.2023; 33(3): 321. CrossRef
Clinical Outcome and Toxicity in the Treatment of Anaplastic Thyroid Cancer in Elderly Patients
Teresa Augustin, Dmytro Oliinyk, Viktoria Florentine Koehler, Josefine Rauch, Claus Belka, Christine Spitzweg, Lukas Käsmann
Journal of Clinical Medicine.2020; 9(10): 3231. CrossRef
Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population
Marc Gregory Yu, Jonathan Rivera, Cecilia Jimeno
Endocrinology and Metabolism.2017; 32(2): 288. CrossRef
Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
Endocrinology and Metabolism.2016; 31(3): 469. CrossRef

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