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Review Article
Bone Metabolism
NF-κB-Mediated Regulation of Osteoclastogenesis
Brendan F. Boyce, Yan Xiu, Jinbo Li, Lianping Xing, Zhenqiang Yao
Endocrinol Metab. 2015;30(1):35-44.   Published online March 27, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.1.35
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AbstractAbstract PDFPubReader   

Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the blood. Major advances in understanding of the molecular mechanisms regulating osteoclast formation and functions have been made in the past 20 years since the discovery that their formation requires nuclear factor-kappa B (NF-κB) signaling and that this is activated in response to the essential osteoclastogenic cytokine, receptor activator of NF-κB ligand (RANKL), which also controls osteoclast activation to resorb (degrade) bone. These studies have revealed that RANKL and some pro-inflammatory cytokines, including tumor necrosis factor, activate NF-κB and downstream signaling, including c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), and inhibition of repressors of NFATc1 signaling, to positively regulate osteoclast formation and functions. However, these cytokines also activate NF-κB signaling that can limit osteoclast formation through the NF-κB signaling proteins, TRAF3 and p100, and the suppressors of c-Fos/NFATc1 signaling, IRF8, and RBP-J. This paper reviews current understanding of how NF-κB signaling is involved in the positive and negative regulation of cytokine-mediated osteoclast formation and activation.

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    Journal of Orthopaedic Translation.2024; 45: 197.     CrossRef
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    Biochemical Pharmacology.2024; 224: 116230.     CrossRef
  • Glycogen Synthase Kinase-3 Beta (GSK3β) as a Potential Drug Target in Regulating Osteoclastogenesis: An Updated Review on Current Evidence
    Sok Kuan Wong
    Biomolecules.2024; 14(4): 502.     CrossRef
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    Jianqi Wang, Shuainan Wu, Lu Liu, Ying Pang, Zhaobao Li, Hong Mu
    International Dental Journal.2023; 73(3): 387.     CrossRef
  • HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling
    Hui-Min Cheng, Mingming Xing, Ya-Ping Zhou, Weitao Zhang, Zeyu Liu, Lan Li, Zuguo Zheng, Yuanchen Ma, Pingping Li, Xiaoxuan Liu, Ping Li, Xiaojun Xu
    Cell Death & Differentiation.2023; 30(3): 673.     CrossRef
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    Weihua Jin, Fen Chen, Qiufu Fang, Genxiang Mao, Yizhong Bao
    Experimental Gerontology.2023; 172: 112057.     CrossRef
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    Heng Qiu, Christopher Hosking, Emel Rothzerg, Ariela Samantha, Kai Chen, Vincent Kuek, Haiming Jin, Sipin Zhu, Alice Vrielink, Kevin Lim, Michael Foley, Jiake Xu
    Journal of Biological Chemistry.2023; 299(2): 102889.     CrossRef
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    Yongdeok Jo, Naboneeta Sarkar, Susmita Bose
    Journal of Materials Chemistry B.2023; 11(24): 5503.     CrossRef
  • The Roles of TRAF3 in Immune Responses
    Mengjiao Lin, Xiaoli Ji, Yan Lv, Dawei Cui, Jue Xie, Dimitri Poddighe
    Disease Markers.2023; 2023: 1.     CrossRef
  • (S)-2-(Cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide Attenuates RANKL-Induced Osteoclast Differentiation by Inhibiting NF-κB Nuclear Translocation
    Mina Ding, Eunjin Cho, Zhihao Chen, Sang-Wook Park, Tae-Hoon Lee
    International Journal of Molecular Sciences.2023; 24(5): 4327.     CrossRef
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    Sun-Ren Sheng, Yu-Hao Wu, Zi-Han Dai, Chen Jin, Gao-Lu He, Shu-Qing Jin, Bi-Yao Zhao, Xin Zhou, Cheng-Long Xie, Gang Zheng, Nai-Feng Tian
    Phytomedicine.2023; 114: 154739.     CrossRef
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    Journal of Medicinal Chemistry.2023; 66(10): 6766.     CrossRef
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    Sayan Deb Dutta, Tejal V. Patil, Keya Ganguly, Aayushi Randhawa, Ki-Taek Lim
    Bioactive Materials.2023; 28: 284.     CrossRef
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    Cell & Bioscience.2023;[Epub]     CrossRef
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    Redox Biology.2023; 64: 102804.     CrossRef
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    Yuechao Dong, Yangshan Chen, Guixing Ma, Huiling Cao
    Acta Pharmaceutica Sinica B.2023; 13(10): 3963.     CrossRef
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    Biomaterials.2023; 301: 122238.     CrossRef
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    Nutrients.2023; 15(14): 3193.     CrossRef
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  • Oxymatrine Attenuates Osteoclastogenesis via Modulation of ROS-Mediated SREBP2 Signaling and Counteracts Ovariectomy-Induced Osteoporosis
    Chao Jiang, Qingliang Ma, Shiyu Wang, Yang Shen, An Qin, Shunwu Fan, Zhiwei Jie
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • S100 Calcium-Binding Protein P Secreted from Megakaryocytes Promotes Osteoclast Maturation
    Seung-Hoon Lee, Hye Jung Ihn, Eui Kyun Park, Jung-Eun Kim
    International Journal of Molecular Sciences.2021; 22(11): 6129.     CrossRef
  • Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling Pathways
    Xue Yang, Jiamin Liang, Ziyi Wang, Yuangang Su, Yunfei Zhan, Zuoxing Wu, Jing Li, Xuedong Li, Runfeng Chen, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Regulation of Osteoclastogenesis and Bone Resorption by miRNAs
    Kazuki Inoue, Courtney Ng, Yuhan Xia, Baohong Zhao
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Genomic locus proteomic screening identifies the NF-κB signaling pathway components NFκB1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells
    Siqi Gao, Matthew Menendez, Katarzyna Kurylowicz, Courtney T. Griffin, Ramani Ramchandran
    PLOS ONE.2021; 16(6): e0253519.     CrossRef
  • IL-3 inhibits rat osteoclast differentiation induced by TNF-α and other pro-osteoclastogenic cytokines
    Vikrant Piprode, Kanupriya Singh, Anil Kumar, Snehal R. Joshi, Mohan R. Wani
    Journal of Biosciences.2021;[Epub]     CrossRef
  • Water Extract of Mentha arvensis L. Attenuates Estrogen Deficiency-Induced Bone Loss by Inhibiting Osteoclast Differentiation
    Seon-A Jang, Youn-Hwan Hwang, Hyun Yang, Jin Ah Ryuk, Taesoo Kim, Hyunil Ha
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Exosomal tumor necrosis factor‐α from hepatocellular cancer cells (Huh‐7) promote osteoclast differentiation
    Ching‐Hao Li, Kalaiselvi Palanisamy, Xin Li, Shao‐Hua Yu, I‐Kuan Wang, Chi‐Yuan Li, Kuo‐Ting Sun
    Journal of Cellular Biochemistry.2021; 122(11): 1749.     CrossRef
  • Curcuminoid (CRE-Ter)/Liposome as delivery platform for anti-osteoclastogenesis via NF-κB/ERK pathways in RANKL-induced RAW 264.7 cells through PLA foams
    Yutthana Pengjam, Pharkphoom Panichayupakaranant, Varaporn Tanrattanakul
    Heliyon.2021; 7(9): e07823.     CrossRef
  • Osteoblast lineage cells and periodontal ligament fibroblasts regulate orthodontic tooth movement that is dependent on Nuclear Factor-kappa B (NF-kB) activation
    Hyeran Helen Jeon, Chia-Ying Yang, Min Kyung Shin, Jingyi Wang, Juhin Hiren Patel, Chun-Hsi Chung, Dana T. Graves
    The Angle Orthodontist.2021; 91(5): 664.     CrossRef
  • Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
    Kerui Wu, Jiamei Feng, Feng Lyu, Fei Xing, Sambad Sharma, Yin Liu, Shih-Ying Wu, Dan Zhao, Abhishek Tyagi, Ravindra Pramod Deshpande, Xinhong Pei, Marco Gabril Ruiz, Hiroyuki Takahashi, Shunsuke Tsuzuki, Takahiro Kimura, Yin-yuan Mo, Yusuke Shiozawa, Ravi
    Nature Communications.2021;[Epub]     CrossRef
  • Non-polar lipid from greenshell mussel (Perna canaliculus) inhibits osteoclast differentiation
    Parkpoom Siriarchavatana, Marlena C. Kruger, Matthew R. Miller, Hong Tian, Frances M. Wolber
    Bone Reports.2021; 15: 101132.     CrossRef
  • The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects
    Wenhao Lu, Wenfeng Xiao, Wenqing Xie, Xin Fu, Linyuan Pan, Hongfu Jin, Yongle Yu, Yi Zhang, Yusheng Li
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling
    Inyoung Kim, Jung Ha Kim, Kabsun Kim, Semun Seong, Keun-Bae Lee, Nacksung Kim
    BMB Reports.2021; 54(9): 482.     CrossRef
  • Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures
    John W. Kennedy, P. Monica Tsimbouri, Paul Campsie, Shatakshi Sood, Peter G. Childs, Stuart Reid, Peter S. Young, Dominic R. M. Meek, Carl S. Goodyear, Matthew J. Dalby
    Scientific Reports.2021;[Epub]     CrossRef
  • Propionibacterium freudenreichii Inhibits RANKL-Induced Osteoclast Differentiation and Ameliorates Rheumatoid Arthritis in Collagen-Induced Arthritis Mice
    Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
    Microorganisms.2021; 10(1): 48.     CrossRef
  • Identification of Critical Functional Modules and Signaling Pathways in Osteoporosis
    Xiaowei Jiang, Pu Ying, Yingchao Shen, Yiming Miu, Wenbin Kong, Tong Lu, Qiang Wang
    Current Bioinformatics.2021; 16(1): 90.     CrossRef
  • Osteogenic and Anti-Osteoclastogenic Properties of the Curcuminoid, CRE-Bin: Ex Vivo Experiments
    Jakkapong Inchai, Amornkan Numit, Suticha Chunta, Piyawut Swangphon, Pharkphoom Panichayupakaranant, Yutthana Pengjam
    SSRN Electronic Journal .2021;[Epub]     CrossRef
  • Biological and structural effects after intraosseous infiltrations of age‐dependent platelet‐rich plasma: An in vivo study
    Diego Delgado, Ane Garate, Pello Sánchez, Ane Miren Bilbao, Gontzal García del Caño, Joan Salles, Mikel Sánchez
    Journal of Orthopaedic Research.2020; 38(9): 1931.     CrossRef
  • Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice
    Dounia Hamoudi, Zineb Bouredji, Laetitia Marcadet, Hideo Yagita, Louis-Bénédict Landry, Anteneh Argaw, Jérôme Frenette
    Human Molecular Genetics.2020; 29(3): 483.     CrossRef
  • The Loss of Profilin 1 Causes Early Onset Paget's Disease of Bone
    Federica Scotto di Carlo, Laura Pazzaglia, Teresa Esposito, Fernando Gianfrancesco
    Journal of Bone and Mineral Research.2020; 35(8): 1387.     CrossRef
  • Characterization of Dysregulated lncRNA-Associated ceRNA Network Reveals Novel lncRNAs With ceRNA Activity as Epigenetic Diagnostic Biomarkers for Osteoporosis Risk
    Meijie Zhang, Luyang Cheng, Yina Zhang
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Osteoimmunology: A Current Update of the Interplay Between Bone and the Immune System
    Christian Guder, Sascha Gravius, Christof Burger, Dieter C. Wirtz, Frank A. Schildberg
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Multifactorial effects of hyperglycaemia, hyperinsulinemia and inflammation on bone remodelling in type 2 diabetes mellitus
    V.A. Shahen, M. Gerbaix, S. Koeppenkastrop, S.F. Lim, K.E. McFarlane, Amanda N.L. Nguyen, X.Y. Peng, N.B. Weiss, T.C. Brennan-Speranza
    Cytokine & Growth Factor Reviews.2020; 55: 109.     CrossRef
  • The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis
    Jung Yun Kang, Namju Kang, Yu-Mi Yang, Jeong Hee Hong, Dong Min Shin
    International Journal of Molecular Sciences.2020; 21(10): 3646.     CrossRef
  • The Inhibition of Inflammatory Signaling Pathway by Secretory Leukocyte Protease Inhibitor can Improve Spinal Cord Injury
    Renzhe Tang, Benson O. A. Botchway, Yanfeng Meng, Yong Zhang, Conghui Zhou, Junsong Jiang, Xuehong Liu
    Cellular and Molecular Neurobiology.2020; 40(7): 1067.     CrossRef
  • Osteoclast signaling-targeting miR-146a-3p and miR-155-5p are downregulated in Paget's disease of bone
    Elizabeth Stephens, Michèle Roy, Martine Bisson, Hoang Dong Nguyen, Michelle S. Scott, Gilles Boire, Luigi Bouchard, Sophie Roux
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(10): 165852.     CrossRef
  • Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration
    Yajuan Xie, Cheng Hu, Yi Feng, Danfeng Li, Tingting Ai, Yulei Huang, Xiaodan Chen, Lijia Huang, Jiali Tan
    Regenerative Biomaterials.2020; 7(3): 233.     CrossRef
  • A review of the latest insights into the mechanism of action of strontium in bone
    Daniella Marx, Alireza Rahimnejad Yazdi, Marcello Papini, Mark Towler
    Bone Reports.2020; 12: 100273.     CrossRef
  • Regulatory network mediated by RBP‐J/NFATc1‐miR182 controls inflammatory bone resorption
    Kazuki Inoue, Xiaoyu Hu, Baohong Zhao
    The FASEB Journal.2020; 34(2): 2392.     CrossRef
  • Cedrol attenuates collagen-induced arthritis in mice and modulates the inflammatory response in LPS-mediated fibroblast-like synoviocytes
    Xue Chen, Jian Shen, Jun-ming Zhao, Jian Guan, Wei Li, Qiang-min Xie, Yu-qing Zhao
    Food & Function.2020; 11(5): 4752.     CrossRef
  • Tablysin-15 inhibits osteoclastogenesis and LPS-induced bone loss via attenuating the integrin αvβ3 pathway
    Qingye Zeng, Wancheng Lu, Zhenhui Deng, Jiena Wu, Ruiyin Guo, Xueqing Xu
    Chemico-Biological Interactions.2020; 327: 109179.     CrossRef
  • The role of cytokines in bone remodeling and the pathogenesis of postmenopausal osteoporosis
    G. A. Ignatenko, I. G. Nemsadze, E. D. Mirovich, A. V. Churilov, E. A. Maylyan, I. S. Glazkov, Z. S. Rumyantceva
    Medical Herald of the South of Russia.2020; 11(2): 6.     CrossRef
  • Effect of echinalkamide identified from Echinacea purpurea (L.) Moench on the inhibition of osteoclastogenesis and bone resorption
    Bo Yoon Chang, Seul Ki Lee, Da Eun Kim, Jin Hye Bae, Thanh Tam Ho, So-Young Park, Mi Kyeong Lee, Sung Yeon Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • A Synthetic Peptide, CK2.3, Inhibits RANKL-Induced Osteoclastogenesis through BMPRIa and ERK Signaling Pathway
    John Nguyen, Semaj Kelly, Ryan Wood, Brian Heubel, Anja Nohe
    Journal of Developmental Biology.2020; 8(3): 12.     CrossRef
  • Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways
    Jiyong Wei, Yicheng Li, Qian Liu, Yanni Lan, Chengming Wei, Kun Tian, Liwei Wu, Chunbo Lin, Jiake Xu, Jinmin Zhao, Yuan Yang
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Polyphenols from grape pomace induce osteogenic differentiation in mesenchymal stem cells
    Elisa Torre, Giorgio Iviglia, Clara Cassinelli, Marco Morra, Nazario Russo
    International Journal of Molecular Medicine.2020;[Epub]     CrossRef
  • Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation
    Bing Ji, Yao Zhang, Changqing Zhen, Michael J Fagan, Qing Yang
    Computer Methods and Programs in Biomedicine.2020; 196: 105677.     CrossRef
  • Collagen VIα2 chain deficiency causes trabecular bone loss by potentially promoting osteoclast differentiation through enhanced TNFα signaling
    Hai T. Pham, Vardit Kram, Qurratul-Ain Dar, Taishi Komori, Youngmi Ji, Payam Mohassel, Jachinta Rooney, Li Li, Tina M. Kilts, Carsten Bonnemann, Shireen Lamande, Marian F. Young
    Scientific Reports.2020;[Epub]     CrossRef
  • Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis
    Shareen Singh, Thakur Gurjeet Singh, Kriti Mahajan, Sonia Dhiman
    Journal of Pharmacy and Pharmacology.2020; 72(10): 1306.     CrossRef
  • The regulatory role of the RANKL/RANK/OPG signaling pathway in the mechanisms of tooth eruption in patients with impacted teeth
    Ludmila Brodetska, Larysa Natrus, Olha Lisakovska, Olexandr Kaniura, Liudmyla Iakovenko, Irina Skrypnyk, Petro Flis
    BMC Oral Health.2020;[Epub]     CrossRef
  • Activation of Nell-1 in BMSC Sheet Promotes Implant Osseointegration Through Regulating Runx2/Osterix Axis
    Kaichen Lai, Yue Xi, Xue Du, Zhiwei Jiang, Yongzheng Li, Tingben Huang, Xiaoyan Miao, Huiming Wang, Ying Wang, Guoli Yang
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Epigenetic Regulators Involved in Osteoclast Differentiation
    Kristina Astleford, Emily Campbell, Andrew Norton, Kim C. Mansky
    International Journal of Molecular Sciences.2020; 21(19): 7080.     CrossRef
  • NIK inhibitor impairs chronic periodontitis via suppressing non-canonical NF-κB and osteoclastogenesis
    Jiang Wang, Bo Wang, Xin Lv, Lei Wang
    Pathogens and Disease.2020;[Epub]     CrossRef
  • Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
    Bettina Sehnert, Harald Burkhardt, Stefan Dübel, Reinhard E. Voll
    Cells.2020; 9(7): 1627.     CrossRef
  • Intrinsic Restriction of TNF-Mediated Inflammatory Osteoclastogenesis and Bone Resorption
    Baohong Zhao
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Grape Seed Proanthocyanidin Extract Prevents Bone Loss via Regulation of Osteoclast Differentiation, Apoptosis, and Proliferation
    Sung Chul Kwak, Yoon-Hee Cheon, Chang Hoon Lee, Hong Young Jun, Kwon-Ha Yoon, Myeung Su Lee, Ju-Young Kim
    Nutrients.2020; 12(10): 3164.     CrossRef
  • Relationship Between Metabolic Syndrome and Bone Health – An Evaluation of Epidemiological Studies and Mechanisms Involved


    Kok-Yong Chin, Sok Kuan Wong, Sophia Ogechi Ekeuku, Kok-Lun Pang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 3667.     CrossRef
  • The Beneficial Effect of Boswellic Acid on Bone Metabolism and Possible Mechanisms of Action in Experimental Osteoporosis
    Bandar E. Al-Dhubiab, Snehal S. Patel, Mohamed A. Morsy, Harika Duvva, Anroop B. Nair, Pran Kishore Deb, Jigar Shah
    Nutrients.2020; 12(10): 3186.     CrossRef
  • Inhibition of Osteoclast Differentiation by Carotenoid Derivatives through Inhibition of the NF-κB Pathway
    Shlomit Odes-Barth, Marina Khanin, Karin Linnewiel-Hermoni, Yifat Miller, Karina Abramov, Joseph Levy, Yoav Sharoni
    Antioxidants.2020; 9(11): 1167.     CrossRef
  • Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways
    Xin Zhi, Qian Chen, Shaojun Song, Zhengrong Gu, Wenqiang Wei, Huiwen Chen, Xiao Chen, Weizong Weng, Qirong Zhou, Jin Cui, Liehu Cao
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Noncanonical NF-κB Signaling Pathway in Liver Diseases
    Qianhui Chen, Xinyu Lu, Xiaoyong Zhang
    Journal of Clinical and Translational Hepatology.2020; 000(000): 1.     CrossRef
  • Hdac3 regulates bone modeling by suppressing osteoclast responsiveness to RANKL
    David H.H. Molstad, Anna M. Mattson, Dana L. Begun, Jennifer J. Westendorf, Elizabeth W. Bradley
    Journal of Biological Chemistry.2020; 295(51): 17713.     CrossRef
  • Insertion Mutation in Tnfrsf11a Causes a Paget's Disease–Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice
    Nerea Alonso, Sachin Wani, Lorraine Rose, Rob J. van't Hof, Stuart H. Ralston, Omar M.E. Albagha
    Journal of Bone and Mineral Research.2020; 36(7): 1376.     CrossRef
  • Rictor Is a Novel Regulator of TRAF6/TRAF3 in Osteoclasts
    Song Xu, Shihai Li, Xianming Liu, Kang Tan, Jiahuan Zhang, Kai Li, Xiaochun Bai, Yue Zhang
    Journal of Bone and Mineral Research.2020; 36(10): 2053.     CrossRef
  • KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy
    Dipranjan Laha, Moonmoon Deb, Hiranmoy Das
    Autophagy.2019; 15(12): 2063.     CrossRef
  • Dissecting the Role of NF-κb Protein Family and Its Regulators in Rheumatoid Arthritis Using Weighted Gene Co-Expression Network
    Jamal S. M. Sabir, Abdelfatteh El Omri, Babajan Banaganapalli, Majed A. Al-Shaeri, Naser A. Alkenani, Mumdooh J. Sabir, Nahid H. Hajrah, Houda Zrelli, Lukasz Ciesla, Khalidah K. Nasser, Ramu Elango, Noor Ahmad Shaik, Muhummadh Khan
    Frontiers in Genetics.2019;[Epub]     CrossRef
  • Bench-to-bedside strategies for osteoporotic fracture: From osteoimmunology to mechanosensation
    Yong Xie, Licheng Zhang, Qi Xiong, Yanpan Gao, Wei Ge, Peifu Tang
    Bone Research.2019;[Epub]     CrossRef
  • Platelet‐rich fibrin/biphasic calcium phosphate impairs osteoclast differentiation and promotes apoptosis by the intrinsic mitochondrial pathway in chronic periodontitis
    Anil Kumar, Jaideep Mahendra, Shila Samuel, Jayamathi Govindraj, Tholcopiyan Loganathan, Yaongamphi Vashum, Little Mahendra, Thiagarajan Krishnamoorthy
    Journal of Periodontology.2019; 90(1): 61.     CrossRef
  • Cyclin‐dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing
    Mehdi Amirhosseini, Magnus Bernhardsson, Pernilla Lång, Göran Andersson, Johan Flygare, Anna Fahlgren
    Journal of Cellular Physiology.2019; 234(9): 16503.     CrossRef
  • Short-term pharmacologic RAGE inhibition differentially affects bone and skeletal muscle in middle-aged mice
    Hannah M. Davis, Alyson L. Essex, Sinai Valdez, Padmini J. Deosthale, Mohammad W. Aref, Matthew R. Allen, Andrea Bonetto, Lilian I. Plotkin
    Bone.2019; 124: 89.     CrossRef
  • Association of SNP-SNP Interactions Between RANKL, OPG, CHI3L1, and VDR Genes With Breast Cancer Risk in Egyptian Women
    Olfat G. Shaker, Mahmoud A. Senousy
    Clinical Breast Cancer.2019; 19(1): e220.     CrossRef
  • Sialoglycoproteins Isolated from the Eggs of Gadus morhua Inhibit Bone Resorption in Ovariectomized Rats by Suppressing the MAPK and NF-κB Pathways
    Lei Mao, Yiming Wang, Meiling Wang, Yufeng Dai, Jingfeng Wang, Changhu Xue
    Journal of Ocean University of China.2019; 18(5): 1174.     CrossRef
  • Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway
    Bing Ji, Yao Zhang, Changqing Zhen, Michael J. Fagan, Qing Yang
    Computers in Biology and Medicine.2019; 107: 257.     CrossRef
  • Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL‐induced osteoclastogenesis
    Haiming Jin, Qingqing Wang, Kai Chen, Ke Xu, Hao Pan, Feifan Chu, Zhen Ye, Ziyi Wang, Jennifer Tickner, Heng Qiu, Chao Wang, Jacob Kenny, Huazi Xu, Te Wang, Jiake Xu
    Journal of Cellular and Molecular Medicine.2019; 23(12): 8355.     CrossRef
  • Regulation of Osteoclast Differentiation and Skeletal Maintenance by Histone Deacetylases
    Bora Faulkner, Kristina Astleford, Kim Mansky
    Molecules.2019; 24(7): 1355.     CrossRef
  • Benzylideneacetone Derivatives Inhibit Osteoclastogenesis and Activate Osteoblastogenesis Independently Based on Specific Structure–Activity Relationship
    Triveni Pativada, Myung Hwan Kim, Jung-Hun Lee, Seong Su Hong, Chun Whan Choi, Yun-Hyeok Choi, Woo Jung Kim, Da-Woon Song, Serk In Park, Eun Jung Lee, Bo-Yeon Seo, Hankyeom Kim, Hong Kyu Kim, Kee Ho Lee, Sung K. Ahn, Jin-Mo Ku, Gil Hong Park
    Journal of Medicinal Chemistry.2019; 62(13): 6063.     CrossRef
  • The Coumarin Derivative 5′-Hydroxy Auraptene Suppresses Osteoclast Differentiation via Inhibiting MAPK and c-Fos/NFATc1 Pathways
    Basem M. Abdallah, Enas M. Ali, Hany Elsawy, Gehan M. Badr, Ashraf M. Abdel-Moneim, Abdullah M. Alzahrani
    BioMed Research International.2019; 2019: 1.     CrossRef
  • Characterizing how probiotic Lactobacillus reuteri 6475 and lactobacillic acid mediate suppression of osteoclast differentiation
    Darin Quach, Narayanan Parameswaran, Laura McCabe, Robert A. Britton
    Bone Reports.2019; 11: 100227.     CrossRef
  • RIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis
    Jooyeon Jhun, Seung Hoon Lee, Se-Young Kim, Jaeyoon Ryu, Ji Ye Kwon, Hyun Sik Na, KyoungAh Jung, Su-Jin Moon, Mi-La Cho, Jun-Ki Min
    Journal of Translational Medicine.2019;[Epub]     CrossRef
  • The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation
    Inyoung Kim, Jung Ha Kim, Kabsun Kim, Semun Seong, Nacksung Kim
    BMB Reports.2019; 52(7): 469.     CrossRef
  • Aminothiazoles inhibit osteoclastogenesis and PGE2 production in LPS‐stimulated co‐cultures of periodontal ligament and RAW 264.7 cells, and RANKL‐mediated osteoclastogenesis and bone resorption in PBMCs
    Anna Kats, Natalija Gerasimcik, Tuomas Näreoja, Jonas Nederberg, Simon Grenlöv, Ekaterina Lagnöhed, Suchita Desai, Göran Andersson, Tülay Yucel‐Lindberg
    Journal of Cellular and Molecular Medicine.2019; 23(2): 1152.     CrossRef
  • Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species
    Andrew Ying Hui Ng, Ziqing Li, Megan M Jones, Shuting Yang, Chunyi Li, Chuanyun Fu, Chengjian Tu, Merry Jo Oursler, Jun Qu, Shuying Yang
    eLife.2019;[Epub]     CrossRef
  • Molecular mechanisms linking peri-implantitis and type 2 diabetes mellitus revealed by transcriptomic analysis
    Tianliang Yu, Aneesha Acharya, Nikos Mattheos, Simin Li, Dirk Ziebolz, Gerhard Schmalz, Rainer Haak, Jana Schmidt, Yu Sun
    PeerJ.2019; 7: e7124.     CrossRef
  • Madecassoside inhibits estrogen deficiency‐induced osteoporosis by suppressing RANKL‐induced osteoclastogenesis
    Qingqing Wang, Lingya Yao, Ke Xu, Haiming Jin, Kai Chen, Ziyi Wang, Qian Liu, Zhen Cao, Jacob kenny, Yuhao Liu, Jennifer Tickner, Huazi Xu, Jiake Xu
    Journal of Cellular and Molecular Medicine.2019; 23(1): 380.     CrossRef
  • Pharmacological Inhibition of NFκB Reduces Prostate Cancer Related Osteoclastogenesis In Vitro and Osteolysis Ex Vivo
    Silvia Marino, Ryan T. Bishop, Giovana Carrasco, John G. Logan, Boya Li, Aymen I. Idris
    Calcified Tissue International.2019; 105(2): 193.     CrossRef
  • TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
    Jinbo Li, Akram Ayoub, Yan Xiu, Xiaoxiang Yin, James O. Sanders, Addisu Mesfin, Lianping Xing, Zhenqiang Yao, Brendan F. Boyce
    Nature Communications.2019;[Epub]     CrossRef
  • A simple and robust reporter gene assay for measuring the bioactivity of anti-RANKL therapeutic antibodies
    Chuanfei Yu, Lan Wang, Yongbo Ni, Junzhi Wang
    RSC Advances.2019; 9(69): 40196.     CrossRef
  • Tatarinan T, an α‐asarone‐derived lignin, attenuates osteoclastogenesis induced by RANKL via the inhibition of NFATc1/c‐Fos expression
    Yuxin Zhang, Zhi Wang, Xiaona Xie, Shaoming Wang, Yingjian Wang, Guihua Quan, Hongbing Wang, Wan‐chun Sun
    Cell Biology International.2019; 43(12): 1471.     CrossRef
  • The Effect of Curcumin on the Differentiation of Mesenchymal Stem Cells into Mesodermal Lineage
    Armita Mahdavi Gorabi, Nasim Kiaie, Saeideh Hajighasemi, Tannaz Jamialahmadi, Muhammed Majeed, Amirhossein Sahebkar
    Molecules.2019; 24(22): 4029.     CrossRef
  • Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases
    Taiwo Samuel Agidigbi, Chaekyun Kim
    International Journal of Molecular Sciences.2019; 20(14): 3576.     CrossRef
  • Identification of anti-inflammatory components in Sinomenii Caulis based on spectrum-effect relationship and chemometric methods
    Lan-Jin Wang, Zheng-Meng Jiang, Ping-Ting Xiao, Jian-Bo Sun, Zhi-Ming Bi, E-Hu Liu
    Journal of Pharmaceutical and Biomedical Analysis.2019; 167: 38.     CrossRef
  • I-BET151 suppresses osteoclast formation and inflammatory cytokines secretion by targetting BRD4 in multiple myeloma
    Ning-Hong Guo, Ji-Fu Zheng, Fu-Ming Zi, Jing Cheng
    Bioscience Reports.2019;[Epub]     CrossRef
  • The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis
    Sadaf Ashraf, Masar Radhi, Peter Gowler, James J. Burston, Raj D. Gandhi, Graeme J. Thorn, Anna M. Piccinini, David A. Walsh, Victoria Chapman, Cornelia H. de Moor
    Scientific Reports.2019;[Epub]     CrossRef
  • An anti-RANKL treatment reduces muscle inflammation and dysfunction and strengthens bone in dystrophic mice
    Dounia Hamoudi, Laetitia Marcadet, Antoine Piette Boulanger, Hideo Yagita, Zineb Bouredji, Anteneh Argaw, Jérôme Frenette
    Human Molecular Genetics.2019; 28(18): 3101.     CrossRef
  • Dual-Purpose Magnesium-Incorporated Titanium Nanotubes for Combating Bacterial Infection and Ameliorating Osteolysis to Realize Better Osseointegration
    Ying Yang, Lihong Liu, Hang Luo, Dou Zhang, Shaorong Lei, Kechao Zhou
    ACS Biomaterials Science & Engineering.2019; 5(10): 5368.     CrossRef
  • Inhibition of Osteoclastogenesis by Thioredoxin-Interacting Protein-Derived Peptide (TN13)
    Mi Kim, Won Kim, Jae-Eun Byun, Jung Choi, Suk Yoon, Inpyo Choi, Haiyoung Jung
    Journal of Clinical Medicine.2019; 8(4): 431.     CrossRef
  • Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model
    Chulwon Kim, Jong Hyun Lee, Jeong-Hyeon Ko, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Gautam Sethi, Kwang Seok Ahn
    Biomolecules.2019; 9(7): 262.     CrossRef
  • Longan fruit increase bone mineral density in zebrafish and ovariectomized rat by suppressing RANKL-induced osteoclast differentiation
    Younglim Son, Eun Mi Lee, Do Yup Lee, Jong Hun Lee, Sangtaek Oh
    Phytomedicine.2019; 59: 152910.     CrossRef
  • From Osteoclast Differentiation to Osteonecrosis of the Jaw: Molecular and Clinical Insights
    Anesi, Generali, Sandoni, Pozzi, Grande
    International Journal of Molecular Sciences.2019; 20(19): 4925.     CrossRef
  • Tetrandrine attenuates the bone erosion in collagen‐induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase
    Yugai Jia, Yumeng Miao, Mengfan Yue, Mei Shu, Zhifeng Wei, Yue Dai
    The FASEB Journal.2018; 32(6): 3398.     CrossRef
  • Bone turnover markers and novel biomarkers in lung cancer bone metastases
    Jiangli Lang, Qian Zhao, Yuedong He, Xijie Yu
    Biomarkers.2018; 23(6): 518.     CrossRef
  • Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation
    Zi’ang Hu, Yilei Chen, Lijiang Song, Jasper H. N. Yik, Dominik R. Haudenschild, Shunwu Fan
    Frontiers in Pharmacology.2018;[Epub]     CrossRef
  • PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice
    Joo-Hee Choi, Ah-Ra Jang, Dong-il Kim, Min-Jung Park, Seul-Ki Lim, Myung-Sun Kim, Jong-Hwan Park
    Experimental & Molecular Medicine.2018; 50(8): 1.     CrossRef
  • Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL‐induced NFAT activation and calcium signaling
    Chuan Liu, Zhen Cao, Wen Zhang, Jennifer Tickner, Heng Qiu, Chao Wang, Kai Chen, Ziyi Wang, Renxiang Tan, Shiwu Dong, Jiake Xu
    Journal of Cellular Physiology.2018; 233(11): 8971.     CrossRef
  • Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis
    Jiaqi Fu, Sarah V. Nogueira, Vincent van Drongelen, Patrick Coit, Song Ling, Edward F. Rosloniec, Amr H. Sawalha, Joseph Holoshitz
    Proceedings of the National Academy of Sciences.2018; 115(18): 4755.     CrossRef
  • LRP1 Suppresses Bone Resorption in Mice by Inhibiting the RANKL-Stimulated NF-κB and p38 Pathways During Osteoclastogenesis
    Di Lu, Jianshuang Li, Huadie Liu, Gabrielle E Foxa, Kevin Weaver, Jie Li, Bart O Williams, Tao Yang
    Journal of Bone and Mineral Research.2018; 33(10): 1773.     CrossRef
  • Effects of Vitamin D on Skeletal Muscle and Athletic Performance
    Geoffrey D. Abrams, David Feldman, Marc R. Safran
    Journal of the American Academy of Orthopaedic Surgeons.2018; 26(8): 278.     CrossRef
  • TRIM38 regulates NF-κB activation through TAB2 degradation in osteoclast and osteoblast differentiation
    Kabsun Kim, Jung Ha Kim, Inyoung Kim, Semun Seong, Nacksung Kim
    Bone.2018; 113: 17.     CrossRef
  • Isosteviol Derivative Inhibits Osteoclast Differentiation and Ameliorates Ovariectomy-Induced Osteoporosis
    Huey-En Tzeng, Po-Hao Huang, Chun-Hao Tsai, Gregory J Tsay, Yi-Ju Lee, Tsurng-Juhn Huang, Tzu-Hung Lin, Ying-Ming Chiu, Yi-Ying Wu
    Scientific Reports.2018;[Epub]     CrossRef
  • 3′‐Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis
    Li‐Jung Kang, Eun‐Soo Kwon, Kwang Min Lee, Chanmi Cho, Jae‐In Lee, Young Bae Ryu, Tae Hyun Youm, Jimin Jeon, Mi Ra Cho, Seon‐Yong Jeong, Sang‐Rae Lee, Wook Kim, Siyoung Yang
    British Journal of Pharmacology.2018; 175(23): 4295.     CrossRef
  • Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
    Laura Meloni, Lynn Verstrepen, Marja Kreike, Jens Staal, Yasmine Driege, Inna Afonina, Rudi Beyaert
    Molecules.2018; 23(12): 3144.     CrossRef
  • Activated protein C suppresses osteoclast differentiation via endothelial protein C receptor, protease-activated receptor-1, sphingosine 1-phosphate receptor, and apolipoprotein E receptor 2
    Kakunoshin Yoshida, Nobuyuki Akita, Takayuki Okamoto, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo, Motomu Shimaoka, Koji Suzuki, Tatsuya Hayashi
    Thrombosis Research.2018; 163: 30.     CrossRef
  • Dietary nutraceuticals as backbone for bone health
    Manoj K. Pandey, Subash C. Gupta, Deepkamal Karelia, Patrick J. Gilhooley, Mehdi Shakibaei, Bharat B. Aggarwal
    Biotechnology Advances.2018; 36(6): 1633.     CrossRef
  • Irisin promotes proliferation but inhibits differentiation in osteoclast precursor cells
    Yaxian Ma, Xiaoyong Qiao, Rujun Zeng, Ran Cheng, Jun Zhang, Yunyao Luo, Ying Nie, Ying Hu, Zhilan Yang, Jing Zhang, Lin Liu, Wenming Xu, Charles C. Xu, Liangzhi Xu
    The FASEB Journal.2018; 32(11): 5813.     CrossRef
  • Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
    Andrew Paul, Joanne Edwards, Christopher Pepper, Simon Mackay
    Cells.2018; 7(10): 176.     CrossRef
  • Rooibos tea extracts inhibit osteoclast formation and activity through the attenuation of NF-κB activity in RAW264.7 murine macrophages
    Shaakirah Moosa, Abe E. Kasonga, Vishwa Deepak, Sumari Marais, Innocentia B. Magoshi, Megan J. Bester, Marlena C. Kruger, Magdalena Coetzee
    Food & Function.2018; 9(6): 3301.     CrossRef
  • Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-κB signalling pathway
    Hari Madhuri Doss, Snigdha Samarpita, Ramamoorthi Ganesan, Mahaboobkhan Rasool
    Life Sciences.2018; 207: 284.     CrossRef
  • Gentiopicroside inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and JNK signaling pathways
    Fangqing Chen, Lin Xie, Ran Kang, Rongrong Deng, Zhipeng Xi, Daoxi Sun, Jin Zhu, Liming Wang
    Biomedicine & Pharmacotherapy.2018; 100: 142.     CrossRef
  • Hesperetin Prevents Bone Resorption by Inhibiting RANKL-Induced Osteoclastogenesis and Jnk Mediated Irf-3/c-Jun Activation
    Qiang Zhang, Xinqiao Tang, Zhong Liu, Xiaoxia Song, Dan Peng, Wei Zhu, Zhengxiao Ouyang, Wanchun Wang
    Frontiers in Pharmacology.2018;[Epub]     CrossRef
  • Anemarrhena�asphodeloides Bunge ameliorates osteoporosis by suppressing osteoclastogenesis
    Jae Lee, Mi Kim, Haesu Lee, Woong Yang
    International Journal of Molecular Medicine.2018;[Epub]     CrossRef
  • RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors
    Zhenqiang Yao, Wei Lei, Rong Duan, Yanyun Li, Lu Luo, Brendan F. Boyce
    Journal of Biological Chemistry.2017; 292(24): 10169.     CrossRef
  • The Alpha 7 Nicotinic Acetylcholine Receptor of Deciduous Dental Pulp Stem Cells Regulates Osteoclastogenesis During Physiological Root Resorption
    Lulu Wang, Zhifei Zhou, Yujiang Chen, Shuai Yuan, Yang Du, Xinke Ju, Lizheng Wu, Xiaojing Wang
    Stem Cells and Development.2017; 26(16): 1186.     CrossRef
  • Unexpected Bone Formation Produced by RANKL Blockade
    Sergio Portal-Núñez, Aranzazu Mediero, Pedro Esbrit, Olga Sánchez-Pernaute, Raquel Largo, Gabriel Herrero-Beaumont
    Trends in Endocrinology & Metabolism.2017; 28(10): 695.     CrossRef
  • Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption
    Nikolaus Binder, Christine Miller, Masaki Yoshida, Kazuki Inoue, Shinichi Nakano, Xiaoyu Hu, Lionel B. Ivashkiv, Georg Schett, Alessandra Pernis, Steven R. Goldring, F. Patrick Ross, Baohong Zhao
    The Journal of Immunology.2017; 198(9): 3436.     CrossRef
  • Suppression of Osteoclastogenesis by Melatonin: A Melatonin Receptor-Independent Action
    Hyung Kim, Ha Kim, Moon-Kyoung Bae, Yong-Deok Kim
    International Journal of Molecular Sciences.2017; 18(6): 1142.     CrossRef
  • The effects of downhill and uphill exercise training on osteogenesis-related factors in ovariectomy-induced bone loss
    Yun-Seok Kang, Chun-Ho Kim, Jeong-Seok Kim
    Journal of Exercise Nutrition & Biochemistry.2017; 21(3): 1.     CrossRef
  • Small leucine rich proteoglycans, a novel link to osteoclastogenesis
    Vardit Kram, Tina M. Kilts, Nisan Bhattacharyya, Li Li, Marian F. Young
    Scientific Reports.2017;[Epub]     CrossRef
  • Dihydromyricetin Protects against Bone Loss in Ovariectomized Mice by Suppressing Osteoclast Activity
    Libo Zhao, Cong Cai, Jing Wang, Liming Zhao, Weijin Li, Changyu Liu, Hanfeng Guan, Yuanli Zhu, Jun Xiao
    Frontiers in Pharmacology.2017;[Epub]     CrossRef
  • MicroRNAs and Periodontal Homeostasis
    X. Luan, X. Zhou, J. Trombetta-eSilva, M. Francis, A.K. Gaharwar, P. Atsawasuwan, T.G.H. Diekwisch
    Journal of Dental Research.2017; 96(5): 491.     CrossRef
  • Hypoxia‐inducible factor 1‐alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl‐4‐hydroxylase 2
    Philippa A Hulley, Tammie Bishop, Aude Vernet, Jurgen E Schneider, James R Edwards, Nick A Athanasou, Helen J Knowles
    The Journal of Pathology.2017; 242(3): 322.     CrossRef
  • mTORC1 Inhibits NF-κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice
    Yue Zhang, Song Xu, Kai Li, Kang Tan, Kangyan Liang, Jian Wang, Junhui Shen, Wenchong Zou, Le Hu, Daozhang Cai, Changhai Ding, Mangmang Li, Guozhi Xiao, Bin Liu, Anling Liu, Xiaochun Bai
    Journal of Bone and Mineral Research.2017; 32(9): 1829.     CrossRef
  • Hepatocyte growth factor and alternative splice variants - expression, regulation and implications in osteogenesis and bone health and repair
    Rachel N. Frisch, Kevin M. Curtis, Kristina K. Aenlle, Guy A. Howard
    Expert Opinion on Therapeutic Targets.2016; 20(9): 1087.     CrossRef
  • CCAAT/Enhancer-binding Protein α (C/EBPα) Is Important for Osteoclast Differentiation and Activity
    Joel Jules, Wei Chen, Xu Feng, Yi-Ping Li
    Journal of Biological Chemistry.2016; 291(31): 16390.     CrossRef
  • Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model
    Chan-Mi Park, Hye-Min Kim, Dong Hyun Kim, Ho-Jin Han, Haneul Noh, Jae-Hyuk Jang, Soo-Hyun Park, Han-Jung Chae, Soo-Wan Chae, Eun Kyoung Ryu, Sangku Lee, Kangdong Liu, Haidan Liu, Jong-Seog Ahn, Young Ock Kim, Bo-Yeon Kim, Nak-Kyun Soung
    Molecules and Cells.2016; 39(12): 855.     CrossRef
  • RBP-J–Regulated miR-182 Promotes TNF-α–Induced Osteoclastogenesis
    Christine H. Miller, Sinead M. Smith, Mahmoud Elguindy, Tuo Zhang, Jenny Z. Xiang, Xiaoyu Hu, Lionel B. Ivashkiv, Baohong Zhao
    The Journal of Immunology.2016; 196(12): 4977.     CrossRef
  • Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation
    Wei Ming, Gan Lu, Sha Xin, Lu Huanyu, Jiang Yinghao, Lei Xiaoying, Xu Chengming, Ruan Banjun, Wang Li, Lu Zifan
    Biochemical and Biophysical Research Communications.2016; 476(4): 412.     CrossRef
  • Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis
    Daniele Bellavia, Viviana Costa, Angela De Luca, Melania Maglio, Stefania Pagani, Milena Fini, Gianluca Giavaresi
    Current Osteoporosis Reports.2016;[Epub]     CrossRef
  • Diarylheptanoid from Curcuma comosa Roxb. suppresses RANKL-induced osteoclast differentiation by decreasing NFATc1 and c-Fos expression via MAPK pathway
    Supatta Chawalitpong, Nilubon Sornkaew, Apichart Suksamrarn, Tanapat Palaga
    European Journal of Pharmacology.2016; 788: 351.     CrossRef
  • NF‐κB acts as a multifunctional modulator in bone invasion by oral squamous cell carcinoma
    Eijiro Jimi, Shoichiro Kokabu, Takuma Matsubara, Chihiro Nakatomi, Kou Matsuo, Seiji Watanabe
    Oral Science International.2016; 13(1): 1.     CrossRef
  • DLX3 negatively regulates osteoclastic differentiation through microRNA-124
    Na Zhao, Dong Han, Yang Liu, Yue Li, Li Zeng, Yixiang Wang, Hailan Feng
    Experimental Cell Research.2016; 341(2): 166.     CrossRef
  • Functional osteoclastogenesis: the baseline variability in blood donor precursors is not associated with age and gender
    Eliana Pivetta, Bruna Wassermann, Pietro Bulian, Agostino Steffan, Alfonso Colombatti, Jerry Polesel, Paola Spessotto
    Oncotarget.2015; 6(31): 31889.     CrossRef
  • The Multiple Roles of Microrna-223 in Regulating Bone Metabolism
    Yong Xie, Lihai Zhang, Yanpan Gao, Wei Ge, Peifu Tang
    Molecules.2015; 20(10): 19433.     CrossRef
  • Andrographolide Inhibits Ovariectomy-Induced Bone Loss via the Suppression of RANKL Signaling Pathways
    Tao Wang, Qian Liu, Lin Zhou, Jin Yuan, Xixi Lin, Rong Zeng, Xiaonan Liang, Jinmin Zhao, Jiake Xu
    International Journal of Molecular Sciences.2015; 16(11): 27470.     CrossRef
  • Molecular and epigenetic basis of macrophage polarized activation
    Chiara Porta, Elena Riboldi, Alessandro Ippolito, Antonio Sica
    Seminars in Immunology.2015; 27(4): 237.     CrossRef
Close layer
Original Articles
Adrenal gland
Herpes Virus Entry Mediator Signaling in the Brain Is Imperative in Acute Inflammation-Induced Anorexia and Body Weight Loss
Kwang Kon Kim, Sung Ho Jin, Byung Ju Lee
Endocrinol Metab. 2013;28(3):214-220.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.214
  • 3,056 View
  • 30 Download
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AbstractAbstract PDFPubReader   
Background

Reduced appetite and body weight loss are typical symptoms of inflammatory diseases. A number of inflammatory stimuli are responsible for the imbalance in energy homeostasis, leading to metabolic disorders. The herpes virus entry mediator (HVEM) protein plays an important role in the development of various inflammatory diseases, such as intestinal inflammation and diet-induced obesity. However, the role of HVEM in the brain is largely unknown. This study aims to investigate whether HVEM signaling in the brain is involved in inflammation-induced anorexia and body weight loss.

Methods

Food intake and body weight were measured at 24 hours after intraperitoneal injection of lipopolysaccharide (LPS) or intracerebroventricular injection of recombinant mouse LIGHT (also called tumor necrosis factor receptor superfamily 14, TNFSF14), an HVEM ligand, into 8- to 10-week-old male C57BL/6 mice and mice lacking HVEM expression (HVEM-/-). We also assessed LPS-induced change in hypothalamic expression of HVEM using immunohistochemistry.

Results

Administration of LPS significantly reduced food intake and body weight, and moreover, increased expression of HVEM in the hypothalamic arcuate nucleus. However, LPS induced only minor decreases in food intake and body weight in HVEM-/- mice. Administration of LIGHT into the brain was very effective at decreasing food intake and body weight in wild-type mice, but was less effective in HVEM-/- mice.

Conclusion

Activation of brain HVEM signaling is responsible for inflammation-induced anorexia and body weight loss.

Citations

Citations to this article as recorded by  
  • Pediatric traumatic brain injury and a subsequent transient immune challenge independently influenced chronic outcomes in male mice
    Rishabh Sharma, Pablo M. Casillas-Espinosa, Larissa K. Dill, Sarah S.J. Rewell, Matthew R. Hudson, Terence J. O'Brien, Sandy R. Shultz, Bridgette D. Semple
    Brain, Behavior, and Immunity.2022; 100: 29.     CrossRef
  • Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration
    Mosiany Letura Kisipan, Rodi Omondi Ojoo, Titus Ikusya Kanui, Klas S. P. Abelson
    Journal of Comparative Physiology A.2022; 208(4): 493.     CrossRef
  • Intestinal Epithelial Toll-like Receptor 4 Deficiency Modifies the Response to the Activity-Based Anorexia Model in a Sex-Dependent Manner: A Preliminary Study
    Pauline Tirelle, Colin Salaün, Alexandre Kauffmann, Christine Bôle-Feysot, Charlène Guérin, Marion Huré, Alexis Goichon, Asma Amamou, Jonathan Breton, Jean-Luc do Rego, Pierre Déchelotte, Najate Achamrah, Moïse Coëffier
    Nutrients.2022; 14(17): 3607.     CrossRef
  • A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury
    Rishabh Sharma, Akram Zamani, Larissa K. Dill, Mujun Sun, Erskine Chu, Marcus J. Robinson, Terence J. O’Brien, Sandy R. Shultz, Bridgette D. Semple
    Journal of Neuroinflammation.2021;[Epub]     CrossRef
  • Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring
    Maide Ozen, Hui Zhao, Flora Kalish, Yang Yang, Lauren L. Jantzie, Ronald J. Wong, David K. Stevenson, Leticia Reyes
    PLOS ONE.2021; 16(6): e0252642.     CrossRef
  • Treatment With Lipopolysaccharide Induces Distinct Changes in Metabolite Profile and Body Weight in 129Sv and Bl6 Mouse Strains
    Maria Piirsalu, Egon Taalberg, Kersti Lilleväli, Li Tian, Mihkel Zilmer, Eero Vasar
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Systemic effects in naïve mice injected with immunomodulatory lectin ArtinM
    Patrícia Kellen Martins Oliveira Brito, Thiago Eleutério Gonçalves, Fabrício Freitas Fernandes, Camila Botelho Miguel, Wellington Francisco Rodrigues, Javier Emílio Lazo Chica, Maria Cristina Roque-Barreira, Thiago Aparecido da Silva, Sujit Kumar Bhutia
    PLOS ONE.2017; 12(10): e0187151.     CrossRef
  • Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
    Seung-Jae Kim, Ji-Young Cha, Hye Suk Kang, Jae-Ho Lee, Ji Yoon Lee, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im
    BMB Reports.2016; 49(5): 276.     CrossRef
  • Patent Highlights April–May 2016
    Hermann AM Mucke
    Pharmaceutical Patent Analyst.2016; 5(5): 301.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Overexpression of CCN3 Inhibits Inflammation and Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice
    Jun Liu, Yingang Ren, Li Kang, Lihua Zhang, Philip Michael Bauer
    PLoS ONE.2014; 9(4): e94912.     CrossRef
Close layer
Obesity and Metabolism
Tumor Necrosis Factor-α as a Predictor for the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Follow-Up Study
Yun Yong Seo, Yong Kyun Cho, Ji-Cheol Bae, Mi Hae Seo, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Endocrinol Metab. 2013;28(1):41-45.   Published online March 25, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.1.41
  • 4,580 View
  • 34 Download
  • 60 Crossref
AbstractAbstract PDFPubReader   
Background

Tumor necrosis factor (TNF)-α is associated with insulin resistance and systemic inflammatory responses. The aim of this study was to investigate the relationship between TNF-α and the development of nonalcoholic fatty liver disease (NAFLD) in a longitudinal study.

Methods

Three hundred and sixty-three apparently healthy subjects (mean age, 40.5±6.1 years; male, 57.6%) without NAFLD were enrolled in 2003. Anthropometric and laboratory measurements were performed. The participants were grouped into tertiles according to their serum TNF-α levels from samples taken in 2003. At a 4-year follow-up, we compared the odds ratios (ORs) of the development of NAFLD according to the tertiles of TNF-α levels measured in 2003.

Results

At the 4-year follow-up, the cumulative incidence of NAFLD was 29.2% (106/363). The group that developed NAFLD had higher levels of TNF-α than those in the group without NAFLD (3.65±1.79 pg/mL vs. 3.15±1.78 pg/mL; P=0.016). When the 2003 serum TNF-α levels were categorized into tertiles: incidence of NAFLD observed in 2007 was significantly higher with increasing tertiles (22.6%, 35.8%, and 41.5%, respectively; P<0.05). The risk of developing NAFLD was significantly greater in the highest tertile of TNF-α than in the lowest tertile after adjusting for age, smoking, and BMI (OR, 2.20; 95% confidence interval, 1.12 to 4.01; P<0.05).

Conclusion

Higher serum TNF-α levels in subjects without NAFLD were associated with the development of NAFLD. The results of study might suggest a pathologic role of inflammation in NAFLD.

Citations

Citations to this article as recorded by  
  • Nigella sativa Efficacy in Non-alcoholic Fatty Liver Disease: Mechanisms and Clinical Effects
    A.A. Sangouni, A. Jamalzehi, M. Moradpour, H. Mozaffari-Khosravi
    Journal of Herbal Medicine.2024; 43: 100833.     CrossRef
  • Berberine prevents NAFLD and HCC by modulating metabolic disorders
    Xinyue Lin, Juanhong Zhang, Yajun Chu, Qiuying Nie, Junmin Zhang
    Pharmacology & Therapeutics.2024; 254: 108593.     CrossRef
  • Antitumor Mechanisms of Lycium barbarum Fruit: An Overview of In Vitro and In Vivo Potential
    Maria Rosaria Miranda, Vincenzo Vestuto, Giuseppina Amodio, Michele Manfra, Giacomo Pepe, Pietro Campiglia
    Life.2024; 14(3): 420.     CrossRef
  • Theabrownin alleviates nonalcoholic fatty liver disease by inhibiting the intestinal farnesoid X receptor–ceramide axis
    Jieyi Wang, Dan Zheng, Kun Ge, Fengjie Huang, Yang Li, Xiaojiao Zheng, Wei Jia, Aihua Zhao
    Food Frontiers.2024;[Epub]     CrossRef
  • Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
    Hong-Ju Sun, Bo Jiao, Yan Wang, Yue-Hua Zhang, Ge Chen, Zi-Xuan Wang, Hong Zhao, Qing Xie, Xiao-Hua Song
    World Journal of Gastroenterology.2024; 30(14): 1968.     CrossRef
  • RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
    Madhuri Basak, Kiran Das, Tarun Mahata, Abhishek Singh Sengar, Sumit Kumar Verma, Sayan Biswas, Kakali Bhadra, Adele Stewart, Biswanath Maity
    Antioxidants & Redox Signaling.2023; 38(1-3): 137.     CrossRef
  • The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD‐rat model
    Naruemon Wikan, Jiraporn Tocharus, Chio Oka, Sivanan Sivasinprasasn, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus
    Journal of Biochemical and Molecular Toxicology.2023;[Epub]     CrossRef
  • Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease
    Jarren R. Oates, Keisuke Sawada, Daniel A. Giles, Pablo C. Alarcon, Michelle S.M.A. Damen, Sara Szabo, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Senad Divanovic
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • 1,25-Dihydroxycholecalciferol down-regulates 3-mercaptopyruvate sulfur transferase and caspase-3 in rat model of non-alcoholic fatty liver disease
    Maher N. Ibrahim, Abeer A. Khalifa, Dalia A. Hemead, Amira Ebrahim Alsemeh, Marwa A. Habib
    Journal of Molecular Histology.2023; 54(2): 119.     CrossRef
  • Effects of Resveratrol Supplementation on Nonalcoholic Fatty Liver Disease Management
    Arefe Nemati, Zeinab Nikniaz, Ali Mota
    Topics in Clinical Nutrition.2023; 38(2): 144.     CrossRef
  • The effects of chicory supplementation on liver enzymes and lipid profiles in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of clinical evidence
    Elham Maleki, Ali Sadeghpour, Erfan Taherifard, Bahareh Izadi, Mehdi Pasalar, Maryam Akbari
    Clinical Nutrition ESPEN.2023; 55: 447.     CrossRef
  • Using bioinformatics and systems biology methods to identify the mechanism of interaction between COVID-19 and nonalcoholic fatty liver disease
    Wenbo Dong, Yan Jin, Hongshuo Shi, Xuecheng Zhang, Jinshu Chen, Hongling Jia, Yongchen Zhang
    Medicine.2023; 102(23): e33912.     CrossRef
  • The Role of Tumor Necrosis Factor-Alpha in the Pathogenesis and Treatment of Nonalcoholic Fatty Liver Disease
    Ilias D. Vachliotis, Stergios A. Polyzos
    Current Obesity Reports.2023; 12(3): 191.     CrossRef
  • NAFLD Is Associated With Quiescent Rather Than Active Crohn’s Disease
    Scott McHenry, Matthew Glover, Ali Ahmed, Quazim Alayo, Maria Zulfiqar, Daniel R Ludwig, Matthew A Ciorba, Nicholas O Davidson, Parakkal Deepak
    Inflammatory Bowel Diseases.2023;[Epub]     CrossRef
  • Gene-regulation modules in nonalcoholic fatty liver disease revealed by single-nucleus ATAC-seq
    Fumihiko Takeuchi, Yi-Qiang Liang, Hana Shimizu-Furusawa, Masato Isono, Mia Yang Ang, Kotaro Mori, Taizo Mori, Eiji Kakazu, Sachiyo Yoshio, Norihiro Kato
    Life Science Alliance.2023; 6(10): e202301988.     CrossRef
  • Effectiveness of Cerium Oxide Nanoparticles in Non-Alcoholic Fatty Liver Disease Evolution Using In Vivo and In Vitro Studies: A Systematic Review
    Cristian Sandoval, Carolina Reyes, Pamela Rosas, Karina Godoy, Vanessa Souza-Mello, Jorge Farías
    International Journal of Molecular Sciences.2023; 24(21): 15728.     CrossRef
  • Maternal betaine supplementation ameliorates fatty liver disease in offspring mice by inhibiting hepatic NLRP3 inflammasome activation
    Lun Li, Liuqiao Sun, Xiaoping Liang, Qian Ou, Xuying Tan, Fangyuan Li, Zhiwei Lai, Chenghe Ding, Hangjun Chen, Xinxue Yu, Qiongmei Wu, Jun Wei, Feng Wu, Lijun Wang
    Nutrition Research and Practice.2023; 17(6): 1084.     CrossRef
  • Association of Inflammatory Cytokines With Non-Alcoholic Fatty Liver Disease
    Yamei Duan, Xiongfeng Pan, Jiayou Luo, Xiang Xiao, Jingya Li, Prince L. Bestman, Miyang Luo
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • A potential link between plasma short‑chain fatty acids, TNF‑α level and disease progression in non‑alcoholic fatty liver disease: A retrospective study
    Jing Xiong, Xia Chen, Zhijing Zhao, Ying Liao, Ting Zhou, Qian Xiang
    Experimental and Therapeutic Medicine.2022;[Epub]     CrossRef
  • Update on Non-Alcoholic Fatty Liver Disease-Associated Single Nucleotide Polymorphisms and Their Involvement in Liver Steatosis, Inflammation, and Fibrosis: A Narrative Review
    Fajar Dwi Astarini, Neneng Ratnasari, Widya Wasityastuti
    Iranian Biomedical Journal.2022; 26(4): 252.     CrossRef
  • Clinical significance of epicardial fat assessment in hypertensive patients with non-alcoholic fatty liver disease
    M. Е. Statsenko, A. M. Streltsova
    "Arterial’naya Gipertenziya" ("Arterial Hypertension").2022; 28(3): 260.     CrossRef
  • The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm
    Sebastian Larion, Caleb A. Padgett, Joshua T. Butcher, James D. Mintz, David J. Fulton, David W. Stepp
    American Journal of Physiology-Gastrointestinal and Liver Physiology.2022; 323(4): G387.     CrossRef
  • Effect of Fiber Supplementation on Systemic Inflammation and Liver Steatosis in Mice Fed with High-Carbohydrate Diets
    Cacilda Rocha Hildebrand Budke, Débora Marchetti Chaves Thomaz, Rodrigo Juliano de Oliveira, Rita de Cássia Avellaneda Guimarães, Amariles Diniz Ramires, Doroty Mesquita Dourado, Elisvânia Freitas dos Santos, Adriana Conceicon Guercio Menezes, Andréia Con
    Metabolic Syndrome and Related Disorders.2022; 20(10): 558.     CrossRef
  • Association between inflammatory markers and non-alcoholic fatty liver disease in obese children
    Yamei Duan, Jiayou Luo, Xiongfeng Pan, Jia Wei, Xiang Xiao, Jingya Li, Miyang Luo
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials
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    Complementary Therapies in Clinical Practice.2021; 42: 101281.     CrossRef
  • Association of xenobiotic-metabolizing enzymes (GSTM1 and GSTT 1), and pro-inflammatory cytokines (TNF-α and IL-6) genetic polymorphisms with non-alcoholic fatty liver disease
    Narges Damavandi, Sirous Zeinali
    Molecular Biology Reports.2021; 48(2): 1225.     CrossRef
  • Potential protective effect of curcumin in high-fat diet-induced nonalcoholic fatty liver disease in rats
    AhmedM M. Mahmouda, NohaA.-R A. El-Hagag, HusseinI El-Bitar, Abdel-HalimM Afifi
    Journal of Current Medical Research and Practice.2021; 6(1): 92.     CrossRef
  • Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease
    Mengyao Zhao, Shumin Chen, Xiaoguo Ji, Xin Shen, Jiangshan You, Xinyi Liang, Hao Yin, Liming Zhao
    Pharmacological Research.2021; 166: 105517.     CrossRef
  • Inflammation in Metabolic Diseases and Insulin Resistance
    Won-Young Lee
    Cardiovascular Prevention and Pharmacotherapy.2021; 3(2): 31.     CrossRef
  • Cellular Mechanisms of Liver Fibrosis
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    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • The role of insulin resistance and systemic inflammation in reducing the elasticity of the main arteries in patients with arterial hypertension and non-alcoholic fatty liver disease
    M.E. Statsenko, A.M. Streltsova, M.I. Turovets
    Profilakticheskaya meditsina.2021; 24(5): 60.     CrossRef
  • Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation
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    Scientific Reports.2021;[Epub]     CrossRef
  • L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia
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    Canadian Journal of Physiology and Pharmacology.2021; 99(11): 1137.     CrossRef
  • Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation
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    Molecular and Cellular Endocrinology.2021; 538: 111464.     CrossRef
  • Low Vitamin D Level was Associated with Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
    Vahid Sheikhi, Zahra Heidari
    Shiraz E-Medical Journal.2021;[Epub]     CrossRef
  • Inflammation and Fibrogenesis in MAFLD: Role of the Hepatic Immune System
    Pietro Torre, Benedetta Maria Motta, Roberta Sciorio, Mario Masarone, Marcello Persico
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Sarcopenia Is an Independent Risk Factor for NAFLD in COPD: A Nationwide Survey (KNHANES 2008–2011)


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    Food & Function.2020; 11(9): 7545.     CrossRef
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    Samukelisiwe C. Shabalala, Phiwayinkosi V. Dludla, Lawrence Mabasa, Abidemi P. Kappo, Albertus K. Basson, Carmen Pheiffer, Rabia Johnson
    Biomedicine & Pharmacotherapy.2020; 131: 110785.     CrossRef
  • Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease
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    International Journal of Molecular Sciences.2020; 21(21): 8113.     CrossRef
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    Frontiers in Nutrition.2020;[Epub]     CrossRef
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    Antioxidants.2019; 8(8): 276.     CrossRef
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    Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1.     CrossRef
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    PLOS ONE.2019; 14(12): e0225792.     CrossRef
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    Electronic Journal of General Medicine.2019; 16(3): em142.     CrossRef
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    The Journal of Korean Diabetes.2017; 18(2): 81.     CrossRef
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    RSC Advances.2017; 7(60): 37967.     CrossRef
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    World Journal of Gastroenterology.2017; 23(19): 3407.     CrossRef
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    Annals of Surgery.2017; 266(2): 324.     CrossRef
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    Y-h Lee, M R Yun, H M Kim, B H Jeon, B-C Park, B-W Lee, E S Kang, H C Lee, Y W Park, B-S Cha
    International Journal of Obesity.2016; 40(2): 356.     CrossRef
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    Frontiers in Immunology.2016;[Epub]     CrossRef
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    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
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The Nonthyroidal Illness Syndrome: Prognostic Value and Circulating Cytokines after Allogeneic Bone Marrow Transplantation.
Ki Won Oh, Moo Il Kang, Won Young Lee, Hyun Shik Son, Kun Ho Yoon, Bong Yun Cha, Kwang Woo Lee, Ho Young Son, Sung Koo Kang, Wan Sik Shin, Woo Sung Min, Choon Choo Kim, Byung Young Ahn, Hyung Sun Sohn
J Korean Endocr Soc. 2000;15(2):214-225.   Published online January 1, 2001
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AbstractAbstract PDF
BACKGROUND
Alteration of thyroid hormone parameters are frequently observed in sick patients and commonly known as nonthyroidal illness syndrome(NTIS) or euthyroid sick syndrome(ESS). NTIS is seen in starvation, surgery, severe illness, and also bone marrow transplantation(BMT). The degree of reduction in thyroid hormone parameters correlated with the severity of NTIS and might predict the prognosis of underlying illness. Recently, particular attention is focused on the role of cytokines in developing the NTIS. This prospective study was designed to assess the relationship of serum thyroid hormone parameters and serum cytokine levels before and in the short-term follow-up after allogeneic BMT in order to predict patients outcome. METHODS: Included 80 patients that were mainly leukemia and severe aplastic anemia. Serum thyroid hormone parameters and serum cytokine levels were measured before and 7, 14, 21, 28 days and 3, and 6 months after BMT. RESULTS: Near-all patients experienced significant decrease of thyroid hormone levels and also significant increase of cytokine levels after BMT. After post-BMT 3 weeks, the serum cytokine levels were negatively correlated with the serum T3 and T4 levels, but not with the serum TSH levels. The patients treated with high-dose steroid or total-body irradiation tended to show lower levels of TSH and more delayed recovery compared to non-treated patients. The patients died after BMT represented generally lower levels of all thyroid hormone parameters than survival patients during entire follow-up period. CONCLUSION: Development of NTIS is associated with higher probability of fatal outcome after BMT and has prognostic relationship in this group of patients. Increased levels of cytokines, especially IL-6 and TNF-alpha, are often found in post-BMT NTIS patients and correlated with the changes in the levels of thyroid hormone parameters.
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Endocrinol Metab : Endocrinology and Metabolism