Fig. 1(A) Differences in low density lipoprotein cholesterol (LDL-C) and (B) apolipoprotein B (apoB) according to the presence of metabolic syndrome. Values are expressed as mean±SE. aAdjusted for LDL-C by analysis of covariance.
Fig. 2(A) Differences in low density lipoprotein cholesterol (LDL-C) and (B) apolipoprotein B (apoB) according to the number of components of metabolic syndrome. Values are expressed as mean±SE. ANOVA, analysis of variance; P for trend, P value by the test for linear trend.
Table 1Comparison of Clinical and Laboratory Variables between MetS and Non-MetS Groups
Variable |
MetS group (n=641) |
Non-MetS group (n=271) |
P value |
Total |
Age, yr |
58.6±12.8 |
58.1±13.4 |
0.59 |
58.4±0.4 |
Male sex, % |
51.8 |
67.9 |
<0.001 |
56.6 |
Duration of diabetes, yr |
9.6±8.6 |
9.1±7.8 |
0.43 |
9.8±0.3 |
Glycated hemoglobin, % |
9.2±2.3 |
9.4±2.8 |
0.342 |
9.3±0.1 |
C-peptide, ng/mL |
2.9±0.1 |
1.9±1.1 |
<0.001 |
2.6±0.1 |
Body mass index, kg/m2
|
26.2±3.9 |
22.9±3.1 |
<0.001 |
25.2±0.1 |
Waist circumference, cm |
92.7±10.0 |
83.4±8.6 |
<0.001 |
89.9±0.3 |
Systolic blood pressure, mm Hg |
135.0±17.4 |
123.4±14.8 |
<0.001 |
131.5±0.6 |
Diastolic blood pressure, mm Hg |
81.4±10.7 |
76.3±9.1 |
<0.001 |
79.9±0.3 |
Triglyceride, mg/dL |
197.7±161.6 |
97.3±47.2 |
<0.001 |
167.9±4.8 |
HDL-C, mg/dL |
43.2±20.1 |
51.4±12.5 |
<0.001 |
45.6±0.6 |
LDL-C, mg/dL |
112.2±40.6 |
102.9±37.3 |
0.001 |
109.4±1.3 |
Apolipoprotein B, mg/dL |
104.5±53.3 |
87.7±33.7 |
<0.001 |
99.5±1.6 |
hsCRP, mg/dL |
0.5±1.9 |
0.4±1.6 |
0.58 |
0.5±0.1 |
Use of antilipidemic agents, % |
49.6 |
36.2 |
<0.001 |
45 |
Table 2Hierarchical Regression Analysis between Apolipoprotein B and Clinical Variables
Variable |
Model 1 (R2 =0.270) |
Model 2 (R2 =0.273) |
Model 3 (R2 =0.287) |
βa
|
P value |
βa
|
P value |
βa
|
P value |
Age |
-0.019 |
0.510 |
-0.021 |
0.468 |
-0.013 |
0.678 |
Male |
0.070 |
0.017 |
0.072 |
0.014 |
0.055 |
0.071 |
LDL-C |
0.490 |
<0.001 |
0.506 |
<0.001 |
0.494 |
<0.001 |
No. of MetS components |
0.120 |
<0.001 |
0.110 |
<0.001 |
0.036 |
0.401 |
Use of antilipidemic agents |
- |
- |
0.064 |
0.031 |
0.055 |
0.064 |
Waist circumference |
- |
- |
- |
- |
-0.006 |
0.863 |
Systolic blood pressure |
- |
- |
- |
- |
0.099 |
0.018 |
Diastolic blood pressure |
- |
- |
- |
- |
-0.040 |
0.314 |
Triglyceride |
- |
- |
- |
- |
0.116 |
<0.001 |
HDL-C |
- |
- |
- |
- |
-0.014 |
0.660 |